US20140034503A1 - Particle transporter - Google Patents
Particle transporter Download PDFInfo
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- US20140034503A1 US20140034503A1 US14/045,806 US201314045806A US2014034503A1 US 20140034503 A1 US20140034503 A1 US 20140034503A1 US 201314045806 A US201314045806 A US 201314045806A US 2014034503 A1 US2014034503 A1 US 2014034503A1
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- Prior art keywords
- electrodes
- particle
- particles
- particle transporter
- dentate portion
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B7/00—Microstructural systems; Auxiliary parts of microstructural devices or systems
- B81B7/02—Microstructural systems; Auxiliary parts of microstructural devices or systems containing distinct electrical or optical devices of particular relevance for their function, e.g. microelectro-mechanical systems [MEMS]
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C5/00—Separating dispersed particles from liquids by electrostatic effect
- B03C5/02—Separators
- B03C5/022—Non-uniform field separators
- B03C5/028—Non-uniform field separators using travelling electric fields, i.e. travelling wave dielectrophoresis [TWD]
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C5/00—Separating dispersed particles from liquids by electrostatic effect
- B03C5/005—Dielectrophoresis, i.e. dielectric particles migrating towards the region of highest field strength
Definitions
- the disclosure relates to a micro device or a micro electromechanical device. Particularly, the disclosure relates to a particle transporter.
- a particle transporter can be implemented to move the particles.
- a fluid driving module is generally used to drive fluid (for example, water) in the particle transporter to flow, and drive the particles in the fluid to move along with flowing of the fluid.
- fluid for example, water
- the conventional technique cannot arbitrarily change the flow direction of the particles or fix positions of the particles, i.e. cannot make the particles to move upstream.
- the additional fluid driving module and related fluid pipes are required, which lead to extra cost.
- An embodiment of the disclosure provides a particle transporter including a first collection electrode and a second collection electrode on a substrate.
- the first collection electrode has a first dentate portion.
- the second collection electrode is located adjacent to the first dentate portion of the first collection electrode.
- the second collection electrode has a second dentate portion at a side adjacent to the first dentate portion.
- a particle collection space is formed around tips of the first dentate portion and the second dentate portion.
- FIG. 1A and FIG. 1B are schematic diagrams illustrating a dielectrophoresis (DEP) phenomenon of particles in an electric field.
- DEP dielectrophoresis
- FIG. 2 is a schematic diagram illustrating a twDEP phenomenon of the particles in the electric field.
- FIG. 3 is a top view of a layout of a particle transporter.
- FIG. 4 is a top view of a layout of a particle transporter according to a first exemplary embodiment of the disclosure.
- FIG. 5 is a top view of a layout of a particle transporter according to a second exemplary embodiment of the disclosure.
- FIG. 6 is a top view of a layout of a particle transporter according to a third exemplary embodiment of the disclosure.
- FIG. 7 is a top view of a layout of a particle transporter according to a fourth exemplary embodiment of the disclosure.
- FIG. 8 is a top view of a layout of a particle transporter according to a fifth exemplary embodiment of the disclosure.
- FIG. 9 is a top view of a layout of a particle transporter according to a sixth exemplary embodiment of the disclosure.
- Particles suspended in an electric field may exhibit an electrophoresis phenomenon due to influence of various forces.
- a low-frequency electric field EF may exert a Coulomb force to charged particles 110 to cause the electrophoresis phenomenon.
- the aforementioned particles include biomedical cells, bacteria, virus or other organic/inorganic particles.
- An interaction between the particles and a non-uniform field may cause a dielectrophoresis (DEP) phenomenon, an electrorotation phenomenon or a travelling-wave dielectrophoresis (twDEP) phenomenon, etc. These phenomena can be used to non-destructively manipulate positions of the particles and move the particles.
- DEP dielectrophoresis
- twDEP travelling-wave dielectrophoresis
- the disclosure is directed to a particle transporter, which uses a dielectrophoresis (DEP) force and a travelling-wave dielectrophoresis (twDEP) force to move/transport particles.
- DEP dielectrophoresis
- twDEP travelling-wave dielectrophoresis
- FIG. 1A and FIG. 1B are schematic diagrams illustrating the DEP phenomenon of the particles 110 in the electric field EF.
- a power supply unit provides a power signal to each electrode.
- an alternating current (AC) power supply 120 provides an AC voltage to two electrodes to produce the AC electric field EF between the two electrodes.
- the low-frequency AC electric field EF induces frequency related dipole moment to the polarizable particles 110 and surrounding fluid. Since the electric field EF is non-uniform, the Coulomb forces exerted to two ends of the particle 110 are different. Therefore, the particle 110 is attracted towards a direction with a stronger Coulomb force.
- AC alternating current
- FIG. 2 is a schematic diagram illustrating the twDEP phenomenon of the particles 110 in the electric field EF.
- a substrate 210 is made of a flexible/rigid non-conductive material, which is for example, a printed circuit board (PCB), etc.
- a plurality of transport electrodes 220 are disposed on the substrate 210 along a straight-line direction (for example, an X-axis direction shown in FIG. 2 ).
- the transport electrodes 220 form a conveyer 200 .
- the transport electrodes 220 respectively have a rectangular shape, and are parallel to each other as that shown in FIG. 2 .
- a width a of the transport electrode 220 and a space b between two adjacent electrodes can adjust/determine a width a of the transport electrode 220 and a space b between two adjacent electrodes according to a characteristic of the particles 110 and a characteristic of the surrounding fluid.
- 0.5a ⁇ b ⁇ 1.5a, and for example, a b.
- These transport electrodes 220 are respectively provided with a set of AC signals, and the AC signals of any two adjacent electrodes of the transport electrodes 220 have a phase difference, which is, for example, 90°.
- a phase difference which is, for example, 90°.
- the AC signal provided to a first transport electrode 220 at the left side has a phase of 0°
- the AC signal of a second transport electrode 220 then has a phase of 90°
- the AC signal of a third transport electrode 220 has a phase of 180°
- the AC signal of a fourth transport electrode 220 has a phase of 270°.
- the AC signals of a fifth to a seventh transport electrodes 220 respectively have phases of 0°, 90°, and 180°.
- these transport electrodes 220 provide an electric field having a travelling wave (with a direction from the left to the right).
- the particles 110 are moved along the travelling wave direction under a travelling-wave dielectrophoresis (twDEP) force, which enables these transport electrodes 220 to provide a straight-line channel to transport the particles 110 .
- twDEP travelling-wave dielectrophoresis
- Lengths of the transport electrodes 220 are approximately the same. Those skilled in the art can configure the lengths of the transport electrodes 220 to be unequal according to an actual design requirement, for example, the lengths of the transport electrodes 220 of FIG. 2 are sequentially decreased from the left to the right (along the X-axis direction). Since the straight-line channel provided by these transport electrodes 220 is narrowed from the left to the right (along the X-axis direction), by moving the particles from the left to the right, a particle collecting effect is also achieved.
- FIG. 3 is a top view of a layout of a particle transporter.
- the particle transporter includes a plurality of turn-around electrodes 310 , for example, turn-around electrodes 311 , 312 , 313 and 314 respectively having a rectangular shape shown in FIG. 3 .
- These turn-around electrodes 311 , 312 , 313 and 314 form a turn-around 300 .
- the turn-around electrodes 311 , 312 , 313 and 314 are disposed on a substrate in a fan shape, and the turn-around electrodes 311 , 312 , 313 and 314 are not connected to each other, as that shown in FIG. 3 .
- a power supply unit provides power signals to the turn-around electrodes 310 of the particle transporter.
- these turn-around electrodes 310 are respectively provided with a set of AC signals, and the AC signals of any two adjacent electrodes in the turn-around electrodes 310 have a phase difference, which is, for example, 90°.
- the AC signal provided to the first turn-around electrode 311 at the left side has a phase of 0°
- the AC signal of the second turn-around electrode 312 then has a phase of 90°
- the AC signal of the third turn-around electrode 313 has a phase of 180°
- the AC signal of the fourth turn-around electrode 314 has a phase of 270°.
- these turn-around electrodes 310 provide an arc channel for transporting the particles 110 .
- a particle 110 - a is moved along the arc channel under a function of the twDEP force (moved along a direction shown by an arrow).
- the space between the electrodes at an outer side is excessively large, the electric field at the outer ring of the arc channel is excessively weak, and the particles 110 (for example, a particle 110 - b ) close to the outer ring of the arc channel can probably escape due to the weak twDEP force.
- FIG. 4 is a top view of a layout of a particle transporter according to a first exemplary embodiment of the disclosure.
- the related descriptions of FIG. 3 can be referred for descriptions of the present exemplary embodiment.
- the particle transporter includes a plurality of turn-around electrodes 410 , for example, turn-around electrodes 411 , 412 , 413 , 414 , 415 , 416 and 417 . These turn-around electrodes 410 form a turn-around 400 .
- the turn-around electrodes 410 are disposed on a substrate in a fan shape, and are not connected to each other, and neighbouring sides of any two adjacent electrodes of the turn-around electrodes 410 are approximately parallel.
- a neighbouring side 401 of the turn-around electrode 411 is approximately parallel to a neighbouring side 402 of the turn-around electrode 412 .
- the turn-around electrodes 411 , 413 , 415 and 417 respectively have a rectangular shape. These rectangular electrodes are arranged on the substrate in a fan shape.
- the turn-around electrodes 412 , 414 and 416 respectively have a triangular shape (or a fan shape). Theses triangular shape (or fan shape) electrodes are disposed between the turn-around electrodes 411 , 413 , 415 and 417 , as shown in FIG. 4 . Therefore, the neighbouring sides of the rectangular electrodes and the triangular (or fan shape) electrodes can be mutually parallel.
- a width of each of the turn-around electrodes 410 and a space between two adjacent electrodes can adjust/determine a width of each of the turn-around electrodes 410 and a space between two adjacent electrodes according to a characteristic of the particles 110 and a characteristic of the surrounding fluid. For example, if the width of the rectangular electrode is a, the space between the rectangular electrode and the triangular electrode is b, and a length of a side opposite to an acute angle of the triangular electrode is c, then 0.5a ⁇ b ⁇ 1.5a, and c ⁇ 2a.
- turn-around electrodes 410 are respectively provided with a set of AC signals, and the AC signals of any two adjacent electrodes of the turn-around electrodes 410 have a phase difference, which is, for example, 90°.
- the AC signal provided to the first turn-around electrode 411 has a phase of 0°
- the AC signal of the second turn-around electrode 412 then has a phase of 90°
- the AC signal of the third turn-around electrode 413 has a phase of 180°
- the AC signal of the fourth turn-around electrode 414 has a phase of 270°.
- the AC signals of the fifth to the seventh turn-around electrodes 415 - 417 respectively have phases of 0°, 90°, and 180°.
- these turn-around electrodes 410 provide an arc channel for transporting the particles 110 .
- a particle 110 - a is moved along an inner ring of the arc channel under a function of the twDEP force (moved along a direction shown by an arrow)
- a particle 110 - b is moved along an outer ring of the arc channel under the function of the twDEP force (moved along a direction shown by an arrow).
- Design of the turn-around electrodes 412 , 414 and 416 mitigates the problem of excessively large space between the electrodes at the outer ring of the arc channel, so that the particles 110 at any positions in the arc channel formed by theses turn-around electrodes can be smoothly turned around without escaping.
- the conveyer 200 of FIG. 2 and the turn-around 400 can be arbitrarily combined according to an actual design requirement, so as to determine/define a moving path of the particles 110 .
- FIG. 5 is a top view of a layout of a particle transporter according to a second exemplary embodiment of the disclosure.
- the related descriptions of FIG. 3 and FIG. 4 can be referred for descriptions of the exemplary embodiment of FIG. 5 .
- the turn-around electrodes 412 , 414 and 416 shown in FIG. 5 respectively have a trapezoidal shape.
- FIG. 6 is a top view of a layout of a particle transporter according to still a third exemplary embodiment of the disclosure.
- the related descriptions of FIG. 3 and FIG. 4 can be referred for descriptions of the exemplary embodiment of FIG. 6 .
- the turn-around electrodes shown in FIG. 5 respectively have a trapezoidal shape.
- Those skilled in the art can change theses turn-around electrodes 410 to the triangular shapes or fan shapes according to an actual design requirement.
- FIG. 7 is a top view of a layout of a particle transporter according to a fourth exemplary embodiment of the disclosure.
- the particle transporter includes a common electrode 710 , a plurality of left switch electrodes 720 and a plurality of right switch electrodes 730 disposed on the substrate.
- the common electrode 710 , the left switch electrodes 720 and the right switch electrodes 730 form a switch 700 .
- the left switch electrodes 720 include electrodes 721 , 722 , 723 , 724 , 725 , 726 , 727 and 728
- the right switch electrodes 730 include electrodes 731 , 732 , 733 , 734 , 735 , 736 , 737 and 738 .
- the common electrode 710 , the electrodes 721 - 728 and the electrodes 731 - 738 respectively have a rectangular shape, and if a width of each rectangular electrode is a, a space between any two electrodes of the rectangular electrodes is b, a and b satisfy an inequality of 0.5a ⁇ b ⁇ 1.5a.
- the left switch electrodes 720 and the right switch electrodes 730 are respectively disposed at a same side of the common electrode 710 .
- the left switch electrodes 720 are disposed on the substrate along a first straight-line direction 741 , and are disposed adjacent to a first end 711 at the same side of the common electrode 710 , and the left switch electrodes 720 are parallel to the common electrode 710 , as that shown in FIG. 7 .
- the left switch electrodes 720 provide a left switch channel to transport the particles 110 .
- the right switch electrodes 730 are disposed on the substrate along a second straight-line direction 742 .
- the right switch electrodes 730 are disposed adjacent to a second end 712 at the same side of the common electrode 710 , and are parallel to the common electrode 710 , as shown in FIG. 7 .
- the right switch electrodes 730 provide a right switch channel to transport the particles 110 .
- the first straight-line direction 741 extending from the first end 711 of the same side of the common electrode 710 does not intersect with the second straight-line direction 742 extending from the second end 712 of the same side of the common electrode 710 , and a common end of the left switch channel and the right switch channel is formed at the common electrode 710 .
- the power supply unit provides power signals to the common electrode 710 , the left switch electrodes 720 and the right switch electrodes 730 in the particle transporter. For example, if the particles 110 are about to be moved along the left switch channel (i.e. along the first straight-line direction 741 ), the left switch electrodes 720 and the common electrode 710 are respectively provided with a set of AC signals, and the right switch electrodes 730 are connected to the ground.
- the AC signals of any two adjacent electrodes of the left switch electrodes 720 and the common electrode 710 have a certain phase difference, which is, for example, 90°. Namely, in FIG.
- the AC signal of the left switch electrode 728 if the AC signal provided to the common electrode 710 has a phase of 0°, the AC signal of the left switch electrode 728 then has a phase of 90 °, the AC signal of the left switch electrode 727 has a phase of 180°, and the AC signal of the left switch electrode 726 has a phase of 270°.
- the AC signals of the left switch electrodes 725 , 724 , 723 , 722 and 721 respectively have phases of 0°, 90°, 180°, 270° and 0°. Therefore, the particles 110 can be moved along the first straight-line direction 741 (along the direction shown by the arrow) through the left switch channel provided by these left switch electrodes 720 .
- the right switch electrodes 730 and the common electrode 710 are respectively provided with a set of AC signals, and the left switch electrodes 720 are connected to the ground.
- the AC signals of any two adjacent electrodes of the right switch electrodes 730 and the common electrode 710 have a certain phase difference, which is, for example, 90°. Namely, if the AC signal provided to the common electrode 710 has a phase of 0°, the AC signal of the right switch electrode 738 then has a phase of 90°, the AC signal of the right switch electrode 737 has a phase of 180°, and the AC signal of the right switch electrode 736 has a phase of 270°.
- the AC signals of the right switch electrodes 735 , 734 , 733 , 732 and 731 respectively have phases of 0°, 90°, 180°, 270° and 0°. Therefore, the particles 110 can be moved along the second straight-line direction 742 (along the direction shown by the arrow) through the right switch channel provided by these right switch electrodes 730 .
- the switch 700 can also collect the particles of different sources to the common end of the left switch channel and the right switch channel, i.e. collect the particles to the common electrode 710 .
- the AC signals of the electrodes 721 and 731 have the phase of 0°
- the AC signals of the electrodes 722 , 726 , 732 and 736 have the phase of 90°
- the AC signals of the electrodes 723 , 727 , 733 and 737 have the phase of 180°
- the AC signals of the electrodes 724 , 728 , 734 and 738 have the phase of 270°
- the AC signals of the electrodes 725 , 735 and 710 have the phase of 0°.
- the particles of different sources are respectively collected to the common electrode 710 through the left switch channel and the right switch channel.
- Lengths of the left switch electrodes 720 and lengths of the corresponding right switch electrodes 730 can be the same.
- the lengths of the left switch electrodes 720 are different, and the lengths of the right switch electrodes 730 are different.
- the lengths of the left switch electrodes 720 are sequentially decreased from the top to the bottom. Therefore, when the particles 110 pass through the left switch channel provided by the left switch electrodes 720 from the top to the bottom, the left switch electrodes 720 can simultaneously move and collect the particles 110 to the common electrode 710 .
- the lengths of the right switch electrodes 730 are sequentially decreased from the top to the bottom. Therefore, when the particles 110 pass through the right switch channel from the top to the bottom, the right switch electrodes 720 can simultaneously move and collect the particles 110 to the common electrode 710 .
- FIG. 8 is a top view of a layout of a particle transporter according to a fifth exemplary embodiment of the disclosure.
- the particle transporter includes a first collection electrode 810 and a second collection electrode 820 disposed on the substrate.
- the first collection electrode and the second collection electrode 820 form a collector 800 .
- the first collection electrode 810 has a first dentate portion S 1
- the first dentate portion S 1 has a plurality of dentations, for example, dentations 811 , 812 , 813 , 814 and 815 .
- the second collection electrode 820 is disposed next to the first collection electrode 810 , and located adjacent to the first dentate portion S 1 .
- the second collection electrode 820 has a second dentate portion S 2 at a side adjacent to the first dentate portion S 1 .
- the second dentate portion S 2 has a plurality of dentations, for example, dentations 821 , 822 , 823 824 .
- a particle collection space is formed around tips of the dentate portions of the first collection electrode 810 and the second collection electrode 820 .
- the dentations 811 - 815 and 821 - 824 all have an acute angle or a right angle, and the dentations of the first dentate portion Si and the dentations of the second dentate portion S 2 are arranged on the substrate in a finger shape. Where, the tips of the dentations 811 - 815 and the tips of the dentations 821 - 824 are approximately aligned to a same straight line 830 , as shown in FIG. 8 .
- the tips of the dentations 811 - 815 and the tips of the dentations 821 - 824 can be arranged beyond the straight line 830 according to an actual design requirement, or the tips of the dentations 811 - 815 and the tips of the dentations 821 - 824 can be arranged without contacting the straight line 830 (or located away from the straight line 830 ).
- the power supply unit provides the power signals to the first collection electrode 810 and the second collection electrode 820 of the particle transporter.
- the first collection electrode 810 and the second collection electrode 820 are respectively provided with an AC signal, and the AC signals of the first collection electrode 810 and the second collection electrode 820 have a certain phase difference, which is, for example, 180°. Namely, if the AC signal provided to the first collection electrode 810 has a phase of 0°, the AC signal of the second collection electrode 820 then has a phase of 180°. Therefore, the particle collection space is formed between the first collection electrode 810 and the second collection electrode 820 . The particles 110 are maintained around the tips of the dentate portions in the particle collection space.
- FIG. 9 is a top view of a layout of a particle transporter 900 according to a sixth exemplary embodiment of the disclosure.
- the particle transporter 900 includes four conveyers 200 , three turn-around 400 , one switch 700 and two collectors 800 .
- FIG. 2 , FIG. 4 , FIG. 7 and FIG. 8 can be referred for implementations of the conveyer 200 , the turn-around 400 , the switch 700 and the collector 800 , and detailed descriptions thereof are not repeated.
- the left switch electrodes 720 of the switch 700 and all of the electrodes at the left part of FIG. 9 are respectively provided with a set of AC signals of properly designed phases, and the right switch electrodes 730 of the switch 700 and all of the electrodes at the right part of FIG. 9 are connected to the ground. Therefore, the particles 110 can move from the conveyer 200 at the bottom of FIG. 9 to the top-left collector 800 through the switch 700 , the turn-around 400 , the conveyer 200 , the turn-around 400 and the conveyer 200 .
- the right switch electrodes 730 of the switch 700 and all of the electrodes at the right part of FIG. 9 are respectively provided with a set of AC signals of properly designed phases, and the left switch electrodes 720 of the switch 700 and all of the electrodes at the left part of FIG. 9 are maintained floating (or connected to the ground). Therefore, the particles 110 can move from the conveyer 200 at the bottom of FIG. 9 to the top-right collector 800 through the switch 700 , the turn-around 400 and the conveyer 200 .
- the AC electric field generated by a plurality of the electrodes on the substrate is used to produce the DEP force and the twDEP force to transport or collect the particles 110 . Therefore, the particle transporter 900 can be used to transport the particles 110 in a static fluid (for example, solution). Since the neighbouring sides of any two adjacent electrodes of the turn-around electrodes in the turn-around 400 are approximately parallel, the particles 110 at any positions in the arc channel formed by the turn-around electrodes can be smoothly turned around without escaping.
- a static fluid for example, solution
- the particle transporters disclosed by the aforementioned exemplary embodiments can be arbitrarily combined with the four basic modules (the conveyer 200 , the turn-around 400 , the switch 700 and the collector 800 ) to implement various transmissions.
- the combined particle transporter can transport the particles 110 along desired transmission paths or fix the particles 110 under a static fluid environment without using other devices to drive the fluid.
- the particle transporters of the aforementioned exemplary embodiments can be applied in biomedical and chemical researches or industries.
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Abstract
A particle transporter based on travelling-wave dielectrophoresis is provided. The particle transporter includes a first collection electrode and a second collection electrode on a substrate. The first collection electrode has a first dentate portion. The second collection electrode is located adjacent to the first dentate portion of the first collection electrode. The second collection electrode has a second dentate portion at a side adjacent to the first dentate portion. Where, a particle collection space is formed around tips of the first dentate portion and the second dentate portion.
Description
- This application is a divisional application of and claims the priority benefit of U.S. application Ser. No. 13/104,016, filed on May 9, 2011, now allowed, which claims the priority benefit of Taiwan application serial no. 100109384, filed on Mar. 18, 2011. The entirety of each of the above-mentioned patent applications is hereby incorporated by reference herein and made a part of specification.
- 1. Technical Field
- The disclosure relates to a micro device or a micro electromechanical device. Particularly, the disclosure relates to a particle transporter.
- 2. Related Art
- In chemical reactions, biochemical reactions (for example, cell separation and integration) and enzymatic reactions, etc., particles in the reaction are generally required to be moved. A particle transporter can be implemented to move the particles. According to a conventional technique, a fluid driving module is generally used to drive fluid (for example, water) in the particle transporter to flow, and drive the particles in the fluid to move along with flowing of the fluid. During the moving process, since the fluid driven by the fluid driving module is maintained in a fixed flow direction, the conventional technique cannot arbitrarily change the flow direction of the particles or fix positions of the particles, i.e. cannot make the particles to move upstream. On the other hand, according to the conventional technique, the additional fluid driving module and related fluid pipes are required, which lead to extra cost.
- An embodiment of the disclosure provides a particle transporter including a first collection electrode and a second collection electrode on a substrate. The first collection electrode has a first dentate portion. The second collection electrode is located adjacent to the first dentate portion of the first collection electrode. The second collection electrode has a second dentate portion at a side adjacent to the first dentate portion. Where, a particle collection space is formed around tips of the first dentate portion and the second dentate portion.
- In order to make the aforementioned and other features and advantages of the invention comprehensible, several exemplary embodiments accompanied with figures are described in detail below.
- The accompanying drawings are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification. The drawings illustrate embodiments of the invention and, together with the description, serve to explain the principles of the invention.
-
FIG. 1A andFIG. 1B are schematic diagrams illustrating a dielectrophoresis (DEP) phenomenon of particles in an electric field. -
FIG. 2 is a schematic diagram illustrating a twDEP phenomenon of the particles in the electric field. -
FIG. 3 is a top view of a layout of a particle transporter. -
FIG. 4 is a top view of a layout of a particle transporter according to a first exemplary embodiment of the disclosure. -
FIG. 5 is a top view of a layout of a particle transporter according to a second exemplary embodiment of the disclosure. -
FIG. 6 is a top view of a layout of a particle transporter according to a third exemplary embodiment of the disclosure. -
FIG. 7 is a top view of a layout of a particle transporter according to a fourth exemplary embodiment of the disclosure. -
FIG. 8 is a top view of a layout of a particle transporter according to a fifth exemplary embodiment of the disclosure. -
FIG. 9 is a top view of a layout of a particle transporter according to a sixth exemplary embodiment of the disclosure. - Particles suspended in an electric field may exhibit an electrophoresis phenomenon due to influence of various forces. A low-frequency electric field EF may exert a Coulomb force to charged
particles 110 to cause the electrophoresis phenomenon. The aforementioned particles include biomedical cells, bacteria, virus or other organic/inorganic particles. An interaction between the particles and a non-uniform field may cause a dielectrophoresis (DEP) phenomenon, an electrorotation phenomenon or a travelling-wave dielectrophoresis (twDEP) phenomenon, etc. These phenomena can be used to non-destructively manipulate positions of the particles and move the particles. - The disclosure is directed to a particle transporter, which uses a dielectrophoresis (DEP) force and a travelling-wave dielectrophoresis (twDEP) force to move/transport particles.
-
FIG. 1A andFIG. 1B are schematic diagrams illustrating the DEP phenomenon of theparticles 110 in the electric field EF. A power supply unit provides a power signal to each electrode. For example, an alternating current (AC)power supply 120 provides an AC voltage to two electrodes to produce the AC electric field EF between the two electrodes. The low-frequency AC electric field EF induces frequency related dipole moment to thepolarizable particles 110 and surrounding fluid. Since the electric field EF is non-uniform, the Coulomb forces exerted to two ends of theparticle 110 are different. Therefore, theparticle 110 is attracted towards a direction with a stronger Coulomb force. InFIG. 1A , when the polarization strength of theparticles 110 is greater than that of the surrounding fluid, the electric field EF have a positive DEP effect on theparticles 110, and theparticles 110 are attracted towards a region with a stronger electric field EF (moved towards directions shown by arrows). InFIG. 1B , when the polarization strength of theparticles 110 is smaller than that of the surrounding fluid, the electric field EF have a negative DEP effect on theparticles 110, and theparticles 110 are moved towards a region with a weaker electric field EF (moved towards directions shown by arrows). -
FIG. 2 is a schematic diagram illustrating the twDEP phenomenon of theparticles 110 in the electric field EF. Asubstrate 210 is made of a flexible/rigid non-conductive material, which is for example, a printed circuit board (PCB), etc. A plurality oftransport electrodes 220 are disposed on thesubstrate 210 along a straight-line direction (for example, an X-axis direction shown inFIG. 2 ). Thetransport electrodes 220 form aconveyer 200. Thetransport electrodes 220 respectively have a rectangular shape, and are parallel to each other as that shown inFIG. 2 . Those skilled in the art can adjust/determine a width a of thetransport electrode 220 and a space b between two adjacent electrodes according to a characteristic of theparticles 110 and a characteristic of the surrounding fluid. In the present exemplary embodiment, 0.5a<b<1.5a, and for example, a=b. - These
transport electrodes 220 are respectively provided with a set of AC signals, and the AC signals of any two adjacent electrodes of thetransport electrodes 220 have a phase difference, which is, for example, 90°. For example, inFIG. 2 , if the AC signal provided to afirst transport electrode 220 at the left side has a phase of 0°,the AC signal of asecond transport electrode 220 then has a phase of 90°, the AC signal of athird transport electrode 220 has a phase of 180°, and the AC signal of afourth transport electrode 220 has a phase of 270°. Deduced by analogy, the AC signals of a fifth to aseventh transport electrodes 220 respectively have phases of 0°, 90°, and 180°. Therefore, thesetransport electrodes 220 provide an electric field having a travelling wave (with a direction from the left to the right). Theparticles 110 are moved along the travelling wave direction under a travelling-wave dielectrophoresis (twDEP) force, which enables thesetransport electrodes 220 to provide a straight-line channel to transport theparticles 110. - Lengths of the
transport electrodes 220 are approximately the same. Those skilled in the art can configure the lengths of thetransport electrodes 220 to be unequal according to an actual design requirement, for example, the lengths of thetransport electrodes 220 ofFIG. 2 are sequentially decreased from the left to the right (along the X-axis direction). Since the straight-line channel provided by thesetransport electrodes 220 is narrowed from the left to the right (along the X-axis direction), by moving the particles from the left to the right, a particle collecting effect is also achieved. -
FIG. 3 is a top view of a layout of a particle transporter. The particle transporter includes a plurality of turn-aroundelectrodes 310, for example, turn-aroundelectrodes FIG. 3 . These turn-aroundelectrodes electrodes electrodes FIG. 3 . - A power supply unit provides power signals to the turn-around
electrodes 310 of the particle transporter. For example, these turn-aroundelectrodes 310 are respectively provided with a set of AC signals, and the AC signals of any two adjacent electrodes in the turn-aroundelectrodes 310 have a phase difference, which is, for example, 90°. For example, inFIG. 3 , if the AC signal provided to the first turn-aroundelectrode 311 at the left side has a phase of 0°, the AC signal of the second turn-aroundelectrode 312 then has a phase of 90°, the AC signal of the third turn-aroundelectrode 313 has a phase of 180°, and the AC signal of the fourth turn-aroundelectrode 314 has a phase of 270°. Therefore, these turn-aroundelectrodes 310 provide an arc channel for transporting theparticles 110. For example, a particle 110-a is moved along the arc channel under a function of the twDEP force (moved along a direction shown by an arrow). However, since the space between the electrodes at an outer side is excessively large, the electric field at the outer ring of the arc channel is excessively weak, and the particles 110 (for example, a particle 110-b) close to the outer ring of the arc channel can probably escape due to the weak twDEP force. -
FIG. 4 is a top view of a layout of a particle transporter according to a first exemplary embodiment of the disclosure. The related descriptions ofFIG. 3 can be referred for descriptions of the present exemplary embodiment. The particle transporter includes a plurality of turn-aroundelectrodes 410, for example, turn-aroundelectrodes electrodes 410 form a turn-around 400. The turn-aroundelectrodes 410 are disposed on a substrate in a fan shape, and are not connected to each other, and neighbouring sides of any two adjacent electrodes of the turn-aroundelectrodes 410 are approximately parallel. For example, a neighbouring side 401 of the turn-aroundelectrode 411 is approximately parallel to aneighbouring side 402 of the turn-aroundelectrode 412. In the present exemplary embodiment, the turn-aroundelectrodes electrodes electrodes FIG. 4 . Therefore, the neighbouring sides of the rectangular electrodes and the triangular (or fan shape) electrodes can be mutually parallel. - Those skilled in the art can adjust/determine a width of each of the turn-around
electrodes 410 and a space between two adjacent electrodes according to a characteristic of theparticles 110 and a characteristic of the surrounding fluid. For example, if the width of the rectangular electrode is a, the space between the rectangular electrode and the triangular electrode is b, and a length of a side opposite to an acute angle of the triangular electrode is c, then 0.5a<b<1.5a, and c<2a. - Theses turn-around
electrodes 410 are respectively provided with a set of AC signals, and the AC signals of any two adjacent electrodes of the turn-aroundelectrodes 410 have a phase difference, which is, for example, 90°. For example, inFIG. 4 , if the AC signal provided to the first turn-aroundelectrode 411 has a phase of 0°, the AC signal of the second turn-aroundelectrode 412 then has a phase of 90°, the AC signal of the third turn-aroundelectrode 413 has a phase of 180°, and the AC signal of the fourth turn-aroundelectrode 414 has a phase of 270°. Deduced by analogy, the AC signals of the fifth to the seventh turn-around electrodes 415-417 respectively have phases of 0°, 90°, and 180°. Therefore, these turn-aroundelectrodes 410 provide an arc channel for transporting theparticles 110. For example, a particle 110-a is moved along an inner ring of the arc channel under a function of the twDEP force (moved along a direction shown by an arrow), and a particle 110-b is moved along an outer ring of the arc channel under the function of the twDEP force (moved along a direction shown by an arrow). Design of the turn-aroundelectrodes particles 110 at any positions in the arc channel formed by theses turn-around electrodes can be smoothly turned around without escaping. - The
conveyer 200 ofFIG. 2 and the turn-around 400 can be arbitrarily combined according to an actual design requirement, so as to determine/define a moving path of theparticles 110. - Implementation of the turn-around 400 is not limited to the above descriptions of
FIG. 4 . Those skilled in the art can implement the turn-around 400 by using other layout structures according to an actual design requirement. For example,FIG. 5 is a top view of a layout of a particle transporter according to a second exemplary embodiment of the disclosure. The related descriptions ofFIG. 3 andFIG. 4 can be referred for descriptions of the exemplary embodiment ofFIG. 5 . Different to the exemplary embodiment ofFIG. 4 , the turn-aroundelectrodes FIG. 5 respectively have a trapezoidal shape. -
FIG. 6 is a top view of a layout of a particle transporter according to still a third exemplary embodiment of the disclosure. The related descriptions ofFIG. 3 andFIG. 4 can be referred for descriptions of the exemplary embodiment ofFIG. 6 . Different to the exemplary embodiment ofFIG. 4 , the turn-around electrodes shown inFIG. 5 respectively have a trapezoidal shape. Those skilled in the art can change theses turn-aroundelectrodes 410 to the triangular shapes or fan shapes according to an actual design requirement. -
FIG. 7 is a top view of a layout of a particle transporter according to a fourth exemplary embodiment of the disclosure. The particle transporter includes acommon electrode 710, a plurality ofleft switch electrodes 720 and a plurality ofright switch electrodes 730 disposed on the substrate. Thecommon electrode 710, theleft switch electrodes 720 and theright switch electrodes 730 form aswitch 700. For example, theleft switch electrodes 720 includeelectrodes right switch electrodes 730 includeelectrodes common electrode 710, the electrodes 721-728 and the electrodes 731-738 respectively have a rectangular shape, and if a width of each rectangular electrode is a, a space between any two electrodes of the rectangular electrodes is b, a and b satisfy an inequality of 0.5a<b<1.5a. - The
left switch electrodes 720 and theright switch electrodes 730 are respectively disposed at a same side of thecommon electrode 710. Theleft switch electrodes 720 are disposed on the substrate along a first straight-line direction 741, and are disposed adjacent to afirst end 711 at the same side of thecommon electrode 710, and theleft switch electrodes 720 are parallel to thecommon electrode 710, as that shown inFIG. 7 . Theleft switch electrodes 720 provide a left switch channel to transport theparticles 110. Theright switch electrodes 730 are disposed on the substrate along a second straight-line direction 742. Theright switch electrodes 730 are disposed adjacent to asecond end 712 at the same side of thecommon electrode 710, and are parallel to thecommon electrode 710, as shown inFIG. 7 . Theright switch electrodes 730 provide a right switch channel to transport theparticles 110. Where, the first straight-line direction 741 extending from thefirst end 711 of the same side of thecommon electrode 710 does not intersect with the second straight-line direction 742 extending from thesecond end 712 of the same side of thecommon electrode 710, and a common end of the left switch channel and the right switch channel is formed at thecommon electrode 710. - The power supply unit provides power signals to the
common electrode 710, theleft switch electrodes 720 and theright switch electrodes 730 in the particle transporter. For example, if theparticles 110 are about to be moved along the left switch channel (i.e. along the first straight-line direction 741), theleft switch electrodes 720 and thecommon electrode 710 are respectively provided with a set of AC signals, and theright switch electrodes 730 are connected to the ground. The AC signals of any two adjacent electrodes of theleft switch electrodes 720 and thecommon electrode 710 have a certain phase difference, which is, for example, 90°. Namely, inFIG. 7 , if the AC signal provided to thecommon electrode 710 has a phase of 0°, the AC signal of theleft switch electrode 728 then has a phase of 90°, the AC signal of the left switch electrode 727 has a phase of 180°, and the AC signal of theleft switch electrode 726 has a phase of 270°. Deduced by analogy, the AC signals of theleft switch electrodes 725, 724, 723, 722 and 721 respectively have phases of 0°, 90°, 180°, 270° and 0°. Therefore, theparticles 110 can be moved along the first straight-line direction 741(along the direction shown by the arrow) through the left switch channel provided by theseleft switch electrodes 720. - If the
particles 110 are about to be moved along the right switch channel (i.e. along the second straight-line direction 742), theright switch electrodes 730 and thecommon electrode 710 are respectively provided with a set of AC signals, and theleft switch electrodes 720 are connected to the ground. The AC signals of any two adjacent electrodes of theright switch electrodes 730 and thecommon electrode 710 have a certain phase difference, which is, for example, 90°. Namely, if the AC signal provided to thecommon electrode 710 has a phase of 0°, the AC signal of theright switch electrode 738 then has a phase of 90°, the AC signal of theright switch electrode 737 has a phase of 180°, and the AC signal of theright switch electrode 736 has a phase of 270°. Deduced by analogy, the AC signals of theright switch electrodes particles 110 can be moved along the second straight-line direction 742 (along the direction shown by the arrow) through the right switch channel provided by theseright switch electrodes 730. - The
switch 700 can also collect the particles of different sources to the common end of the left switch channel and the right switch channel, i.e. collect the particles to thecommon electrode 710. For example, if the AC signals of theelectrodes electrodes electrodes electrodes electrodes common electrode 710 through the left switch channel and the right switch channel. - Lengths of the
left switch electrodes 720 and lengths of the correspondingright switch electrodes 730 can be the same. In the present exemplary embodiment, the lengths of theleft switch electrodes 720 are different, and the lengths of theright switch electrodes 730 are different. For example, inFIG. 7 , the lengths of theleft switch electrodes 720 are sequentially decreased from the top to the bottom. Therefore, when theparticles 110 pass through the left switch channel provided by theleft switch electrodes 720 from the top to the bottom, theleft switch electrodes 720 can simultaneously move and collect theparticles 110 to thecommon electrode 710. Similarly, the lengths of theright switch electrodes 730 are sequentially decreased from the top to the bottom. Therefore, when theparticles 110 pass through the right switch channel from the top to the bottom, theright switch electrodes 720 can simultaneously move and collect theparticles 110 to thecommon electrode 710. - Those skilled in the art can arbitrarily combine the
conveyer 200 ofFIG. 2 , the turn-around 400 ofFIGS. 4-6 and/or theswitch 700 ofFIG. 7 according to an actual design requirement, so as to determine/define a moving path of theparticles 110 in the particle transporter. -
FIG. 8 is a top view of a layout of a particle transporter according to a fifth exemplary embodiment of the disclosure. The particle transporter includes afirst collection electrode 810 and asecond collection electrode 820 disposed on the substrate. The first collection electrode and thesecond collection electrode 820 form acollector 800. Thefirst collection electrode 810 has a first dentate portion S1, and the first dentate portion S1 has a plurality of dentations, for example,dentations second collection electrode 820 is disposed next to thefirst collection electrode 810, and located adjacent to the first dentate portion S1. Thesecond collection electrode 820 has a second dentate portion S2 at a side adjacent to the first dentate portion S1. The second dentate portion S2 has a plurality of dentations, for example,dentations first collection electrode 810 and thesecond collection electrode 820. - The dentations 811-815 and 821-824 all have an acute angle or a right angle, and the dentations of the first dentate portion Si and the dentations of the second dentate portion S2 are arranged on the substrate in a finger shape. Where, the tips of the dentations 811-815 and the tips of the dentations 821-824 are approximately aligned to a same
straight line 830, as shown inFIG. 8 . The tips of the dentations 811-815 and the tips of the dentations 821-824 can be arranged beyond thestraight line 830 according to an actual design requirement, or the tips of the dentations 811-815 and the tips of the dentations 821-824 can be arranged without contacting the straight line 830 (or located away from the straight line 830). - The power supply unit provides the power signals to the
first collection electrode 810 and thesecond collection electrode 820 of the particle transporter. For example, thefirst collection electrode 810 and thesecond collection electrode 820 are respectively provided with an AC signal, and the AC signals of thefirst collection electrode 810 and thesecond collection electrode 820 have a certain phase difference, which is, for example, 180°. Namely, if the AC signal provided to thefirst collection electrode 810 has a phase of 0°, the AC signal of thesecond collection electrode 820 then has a phase of 180°. Therefore, the particle collection space is formed between thefirst collection electrode 810 and thesecond collection electrode 820. Theparticles 110 are maintained around the tips of the dentate portions in the particle collection space. - Those skilled in the art can arbitrarily combine the
conveyer 200 ofFIG. 2 , the turn-around 400 ofFIGS. 4-6 , theswitch 700 ofFIG. 7 and/or thecollector 800 ofFIG. 8 according to an actual design requirement, so as to determine/define a moving path of theparticles 110 in the particle transporter. For example,FIG. 9 is a top view of a layout of aparticle transporter 900 according to a sixth exemplary embodiment of the disclosure. Theparticle transporter 900 includes fourconveyers 200, three turn-around 400, oneswitch 700 and twocollectors 800. Related descriptions ofFIG. 2 ,FIG. 4 ,FIG. 7 andFIG. 8 can be referred for implementations of theconveyer 200, the turn-around 400, theswitch 700 and thecollector 800, and detailed descriptions thereof are not repeated. - If the
particles 110 are about to be moved from the bottom ofFIG. 9 to the top-leftcollector 800, theleft switch electrodes 720 of theswitch 700 and all of the electrodes at the left part ofFIG. 9 are respectively provided with a set of AC signals of properly designed phases, and theright switch electrodes 730 of theswitch 700 and all of the electrodes at the right part ofFIG. 9 are connected to the ground. Therefore, theparticles 110 can move from theconveyer 200 at the bottom ofFIG. 9 to the top-leftcollector 800 through theswitch 700, the turn-around 400, theconveyer 200, the turn-around 400 and theconveyer 200. - If the
particles 110 are about to be moved from the bottom ofFIG. 9 to the top-right collector 800, theright switch electrodes 730 of theswitch 700 and all of the electrodes at the right part ofFIG. 9 are respectively provided with a set of AC signals of properly designed phases, and theleft switch electrodes 720 of theswitch 700 and all of the electrodes at the left part ofFIG. 9 are maintained floating (or connected to the ground). Therefore, theparticles 110 can move from theconveyer 200 at the bottom ofFIG. 9 to the top-right collector 800 through theswitch 700, the turn-around 400 and theconveyer 200. - In summary, in the
particle transporter 900 of the above exemplary embodiment, the AC electric field generated by a plurality of the electrodes on the substrate is used to produce the DEP force and the twDEP force to transport or collect theparticles 110. Therefore, theparticle transporter 900 can be used to transport theparticles 110 in a static fluid (for example, solution). Since the neighbouring sides of any two adjacent electrodes of the turn-around electrodes in the turn-around 400 are approximately parallel, theparticles 110 at any positions in the arc channel formed by the turn-around electrodes can be smoothly turned around without escaping. The particle transporters disclosed by the aforementioned exemplary embodiments can be arbitrarily combined with the four basic modules (theconveyer 200, the turn-around 400, theswitch 700 and the collector 800) to implement various transmissions. The combined particle transporter can transport theparticles 110 along desired transmission paths or fix theparticles 110 under a static fluid environment without using other devices to drive the fluid. The particle transporters of the aforementioned exemplary embodiments can be applied in biomedical and chemical researches or industries. - It will be apparent to those skilled in the art that various modifications and variations can be made to the structure of the invention without departing from the scope or spirit of the invention. In view of the foregoing, it is intended that the invention cover modifications and variations of this invention provided they fall within the scope of the following claims and their equivalents.
Claims (12)
1. A particle transporter, comprising:
a power supply unit, for providing power signals to electrodes in the particle transporter;
a first collection electrode, disposed on a substrate, and having a first dentate portion; and
a second collection electrode, disposed on the substrate and located adjacent to the first dentate portion of the first collection electrode, and having a second dentate portion at a side adjacent to the first dentate portion,
wherein a particle collection space is formed around tips of the first dentate portion and the second dentate portion.
2. The particle transporter as claimed in claim 1 , wherein any dentation of the first dentate portion and the second dentate portion has an acute angle or a right angle.
3. The particle transporter as claimed in claim 1 , wherein a tip of any dentation of the first dentate portion and the second dentate portion is approximately aligned to a same straight line.
4. The particle transporter as claimed in claim 1 , wherein dentations of the first dentate portion and the second dentate portion are arranged in a finger shape.
5. The particle transporter as claimed in claim 1 , wherein the power signals are AC signals, and the AC signals of the first collection electrode and the second collection electrode have a phase difference.
6. The particle transporter as claimed in claim 5 , wherein the phase difference is 180 degrees.
7. The particle transporter as claimed in claim 1 , further comprising:
a plurality of transport electrodes, disposed on the substrate along a third straight-line direction, wherein the transport electrodes are parallel to each other and provide a straight-line channel for transporting the particles.
8. The particle transporter as claimed in claim 7 , wherein the transport electrodes respectively have a rectangular shape, wherein a width of each of the transport electrodes is a, and a space between any two adjacent electrodes of the transport electrodes is b, then 0.5a<b<1.5a.
9. The particle transporter as claimed in claim 7 , wherein lengths of the transport electrodes are approximately the same.
10. The particle transporter as claimed in claim 7 , wherein the power signals are AC signals, and the AC signals of any two adjacent electrodes of the transport electrodes have a phase difference.
11. The particle transporter as claimed in claim 10 , wherein the phase difference is 90 degrees.
12. The particle transporter as claimed in claim 1 , wherein the substrate is a printed circuit board (PCB).
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US14/045,806 US20140034503A1 (en) | 2011-03-18 | 2013-10-04 | Particle transporter |
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TW100109384A TWI419738B (en) | 2011-03-18 | 2011-03-18 | Particle transporter |
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US13/104,016 US8603312B2 (en) | 2011-03-18 | 2011-05-09 | Particle transporter |
US14/045,806 US20140034503A1 (en) | 2011-03-18 | 2013-10-04 | Particle transporter |
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US13/104,016 Division US8603312B2 (en) | 2011-03-18 | 2011-05-09 | Particle transporter |
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US14/045,806 Abandoned US20140034503A1 (en) | 2011-03-18 | 2013-10-04 | Particle transporter |
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TWI511790B (en) * | 2013-07-11 | 2015-12-11 | Univ Nat Taiwan | A microfluidic device based on an electrode array |
US10202474B2 (en) | 2015-09-11 | 2019-02-12 | Bridgestone Corporation | Process for producing polydienes |
DE102018210693A1 (en) | 2018-06-29 | 2020-01-02 | Robert Bosch Gmbh | Device and method for the dielectric separation of particles |
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WO2009052123A2 (en) * | 2007-10-17 | 2009-04-23 | Advanced Liquid Logic, Inc. | Multiplexed detection schemes for a droplet actuator |
WO2010006166A2 (en) * | 2008-07-09 | 2010-01-14 | Advanced Liquid Logic, Inc. | Bead manipulation techniques |
US20100320088A1 (en) * | 2006-12-05 | 2010-12-23 | Commissariat A L'energie | Microdevice for treating liquid specimens |
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GB9916850D0 (en) * | 1999-07-20 | 1999-09-22 | Univ Wales Bangor | Dielectrophoretic apparatus & method |
US6665127B2 (en) * | 2002-04-30 | 2003-12-16 | Lucent Technologies Inc. | Method and apparatus for aligning a photo-tunable microlens |
US7390387B2 (en) * | 2004-03-25 | 2008-06-24 | Hewlett-Packard Development Company, L.P. | Method of sorting cells in series |
WO2005122672A2 (en) * | 2004-06-16 | 2005-12-29 | The University Of British Columbia | Microfluidic transport by electrostatic deformation of fluidic interfaces |
ITBO20050646A1 (en) * | 2005-10-26 | 2007-04-27 | Silicon Biosystem S R L | METHOD AND APPARATUS FOR CHARACTERIZATION AND COUNTING OF PARTICLES |
TW201024732A (en) | 2008-12-22 | 2010-07-01 | Chien-Ming Chen | Microfluidics chip and driving method thereof |
-
2011
- 2011-03-18 TW TW100109384A patent/TWI419738B/en not_active IP Right Cessation
- 2011-05-09 US US13/104,016 patent/US8603312B2/en not_active Expired - Fee Related
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2013
- 2013-10-04 US US14/045,794 patent/US20140034502A1/en not_active Abandoned
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US20100320088A1 (en) * | 2006-12-05 | 2010-12-23 | Commissariat A L'energie | Microdevice for treating liquid specimens |
WO2009052123A2 (en) * | 2007-10-17 | 2009-04-23 | Advanced Liquid Logic, Inc. | Multiplexed detection schemes for a droplet actuator |
WO2010006166A2 (en) * | 2008-07-09 | 2010-01-14 | Advanced Liquid Logic, Inc. | Bead manipulation techniques |
Non-Patent Citations (1)
Title |
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Morganti (AC electrokinetic analysis of chemically modified microparticles, THESIS). * |
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US20140034502A1 (en) | 2014-02-06 |
US20120234680A1 (en) | 2012-09-20 |
US8603312B2 (en) | 2013-12-10 |
TWI419738B (en) | 2013-12-21 |
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