US20120226174A1 - Pulse wave velocity measurement device and pulse wave velocity measurement program - Google Patents

Pulse wave velocity measurement device and pulse wave velocity measurement program Download PDF

Info

Publication number
US20120226174A1
US20120226174A1 US13/508,933 US201013508933A US2012226174A1 US 20120226174 A1 US20120226174 A1 US 20120226174A1 US 201013508933 A US201013508933 A US 201013508933A US 2012226174 A1 US2012226174 A1 US 2012226174A1
Authority
US
United States
Prior art keywords
pulse wave
wave
reference time
amplitude
ejection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US13/508,933
Other languages
English (en)
Inventor
Yutaka Ikeda
Atsushi Hori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sharp Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Assigned to SHARP KABUSHIKI KAISHA reassignment SHARP KABUSHIKI KAISHA ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HORI, ATSUSHI, IKEDA, YUTAKA
Publication of US20120226174A1 publication Critical patent/US20120226174A1/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0285—Measuring or recording phase velocity of blood waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • A61B5/02125—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics of pulse wave propagation time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7239—Details of waveform analysis using differentiation including higher order derivatives

Definitions

  • the present invention relates to a pulse wave velocity measurement device and a pulse wave velocity measurement program for measuring pulse waves of a living body and thereby calculating velocities at which the pulse waves are propagated.
  • pulse waves have various important information for grasp on a state of a circulatory system of a living body.
  • a velocity and time for propagation of a pulse wave between two sites in a living body are living-body indices that have drawn attention from the medical work front because a possibility has been pointed out that a state of arteriosclerosis may be grasped by the indices, and are called Pulse Wave Velocity (PWV) and Pulse Transit Time (PTT), respectively, or the like.
  • PWV Pulse Wave Velocity
  • PTT Pulse Transit Time
  • a plurality of measurement methods according to measurement sites have been proposed for the pulse wave velocity, and the pulse wave velocity between a carotid artery and a femoral artery, for instance, is called cfPWV (carotid-femoral PWV) and is used as a gold standard of the pulse wave velocity (PWV).
  • cfPWV carotid-femoral PWV
  • PWV pulse wave velocity
  • a pulse wave measured at any site on a living body is a resultant wave of an ejection wave from the heart and reflected waves reflected from various sites in the living body.
  • separation into the ejection wave and the reflected waves may make it possible to find the pulse wave velocity or the pulse transit time even it only one measurement point for pulse waves exists.
  • Non-Patent Literature 1 therefore, a technique for separating the ejection wave and the reflected waves is disclosed.
  • Patent Literature 1 and Patent Literature 2 there are disclosed techniques for finding the pulse wave velocity or the pulse transit time by separating the ejection wave and the reflected waves even in presence of only one measurement point for pulse waves.
  • reflection of pulse waves occurs at various sites in a living body.
  • the reflection of pulse waves is caused mainly by impedance mismatch in blood vessels and thus occurs at sites having blood vessel bifurcation, variation in elastic force in blood vessel or the like, for instance.
  • Patent Literature 2 Disclosed in Patent Literature 2 is a technique for calculating the pulse wave velocity or the pulse transit time and finding a blood pressure from pulse waves obtained at one measurement point on basis of a correlation between the pulse wave velocity or the pulse transit time and the blood pressure. Disclosed in Non-Patent Literature 2 is a technique for calculating the pulse wave velocity or the pulse transit time and finding a blood pressure from pulse waves obtained at two measurement points.
  • the pulse wave velocity or the pulse transit time can be found on basis of pulse waves at the one measurement point, and this is based on a premise that the pulse wave velocities of the ejection wave and the reflected waves are equal. According to the premise, (1) one pulse wave is separated into an ejection wave and a reflected wave and a time difference between both the waves is found, and (2) a difference between pulse wave propagation distances of the ejection wave and the reflected wave is found. The pulse wave velocity or the pulse transit time is calculated therefrom.
  • the pulse wave velocities of the ejection wave and the reflected wave do not actually coincide with each other. That is because amplitudes of the ejection wave and the reflected wave differ.
  • the pulse wave velocity is correlated with the blood pressure, which relates to the amplitude of the pulse wave. That is, the pulse wave velocity relates to the amplitude of the pulse wave.
  • a waveform of a pulse wave can satisfactorily be explained on assumption that the reflection point of the reflected wave is in vicinity of the abdominal aorta.
  • the reflection of pulse waves is caused by the impedance mismatch in aortas and the abdominal aorta, degrees of the mismatch differ among individuals and according to physical conditions and conditions of blood vessels in one individual.
  • the amplitude of the reflected wave differs from that of the traveling wave, and degrees of the difference differ among individuals. This results in a difference in the pulse wave velocity between the ejection wave and the reflected wave.
  • Patent Literature 1 JP 2003-010139 A
  • Patent Literature 2 JP 2007-007075 A
  • Non-Patent Literature 1 Takazawa K at al. “Underestimation of vasodilator effects of nitroglycerin by upper limb blood pressure”, Hypertension 1995; 26:520-3
  • Non-Patent Literature 2 McCombie, Devin “Development of a wearable blood pressure monitor using adaptive calibration of peripheral pulse transit time measurements”, Ph.D. Thesis, Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2008.
  • an object of the invention is to provide a pulse wave velocity measurement device and a pulse wave velocity measurement program by which a pulse wave velocity can more accurately be found on basis of pulse waves at one measurement site.
  • a pulse wave velocity measurement device comprises:
  • a pulse wave detection unit for detecting a pulse wave at one site in a living body
  • a reference time detection unit for detecting reference time for identification of an ejection wave component included in the pulse wave at the one site that is detected by the pulse wave detection unit and reference time for identification of a reflected wave component included in the pulse wave
  • a pulse wave amplitude detection unit for detecting an amplitude of the pulse wave that corresponds to the reference time for the ejection wave component detected by the reference time detection unit and detecting an amplitude of the pulse wave that corresponds to the reference time for the reflected wave component detected by the reference time detection unit
  • a pulse wave velocity detection unit for finding a velocity of the pulse wave at which the pulse wave propagates, on basis of the reference time for the ejection wave component and the reference time for the reflected wave component that have been detected by the reference time detection unit and the amplitude of the pulse wave that corresponds to the reference time for the ejection wave component and the amplitude of the pulse wave that corresponds to the reference time for the reflected wave component which amplitudes have been detected by the pulse wave amplitude detection unit.
  • the pulse wave velocity measurement device of the invention detects the reference times for the ejection wave component and for the reflected wave component of the pulse wave by the reference time detection unit and detects the amplitudes of the pulse wave that correspond to the reference times for the ejection wave component and for the reflected wave component by the pulse wave amplitude detection unit.
  • the pulse wave velocity detection unit finds the velocity of the pulse wave on basis of the reference times for the ejection wave component and for the reflected wave component, and the amplitudes of the pulse wave that correspond to the reference times for the ejection wave component and for the reflected wave component.
  • the pulse wave velocity can be measured with high accuracy in consideration of a difference between the pulse wave velocities of the ejection wave and the reflected wave which difference is caused by a difference between the amplitude of the ejection wave component and the amplitude of the reflected wave component.
  • the pulse wave amplitude detection unit includes an ejection wave component elimination unit for finding an ejection wave component included in the amplitude of the pulse wave that corresponds to the reference time for the reflected wave component, eliminating the ejection wave component from the amplitude of the pulse wave that corresponds to the reference time for the reflected wave component, and thereby finding an amplitude of the reflected wave component that corresponds to the reference time for the reflected wave component, and
  • the pulse wave velocity detection unit finds the velocity of the pulse wave on basis of the reference time for the ejection wave component and the reference time for the reflected wave component that have been detected by the reference time detection unit, the amplitude of the pulse wave that corresponds to the reference time for the ejection wave component that has been detected by the pulse wave amplitude detection unit, and the amplitude of the reflected wave component that has been found by the ejection wave component elimination unit.
  • the ejection wave component elimination unit eliminates the ejection wave component from the amplitude of the pulse wave that corresponds to the reference time for the reflected wave component and thereby finds the amplitude of the reflected wave component that corresponds to the reference time for the reflected wave component, so that the amplitude of the reflected wave component that corresponds to the reference time for the reflected wave component can accurately be found. Therefore, the velocity of the pulse wave can accurately be found by the pulse wave velocity detection unit.
  • the pulse wave velocity detection unit finds the velocity of the pulse wave on basis of a time difference between the reference time for the ejection wave component and the reference time for the reflected wave component that have been detected by the reference time detection unit, and an amplitude difference between the amplitude of the pulse wave that corresponds to the reference time for the ejection wave component and that has been detected by the pulse wave amplitude detection unit and the amplitude of the reflected wave component that has been found by the ejection wave component elimination unit.
  • the velocity of the pulse wave can accurately be found on basis of the time difference between the reference time for the ejection wave component and the reference time for the reflected wave component that have been detected by the reference time detection unit and on basis of the amplitude difference between the amplitude of the pulse wave that corresponds to the reference time for the ejection wave component that is detected by the pulse wave amplitude detection unit and the amplitude of the reflected wave component that has been found by the ejection wave component elimination unit.
  • a pulse wave velocity measurement program that makes a computer according to one embodiment, executes:
  • a pulse wave velocity deriving function of calculating a velocity of the pulse wave at which the pulse wave propagates, on basis of the reference time for the ejection wave component, the reference time for the reflected wave component, the amplitude of the pulse wave that corresponds to the reference time for the ejection wave component, and the amplitude of the pulse wave that corresponds to the reference time for the reflected wave component.
  • the computer is made to execute the reference time deriving function to find the reference times for the identification of the ejection wave component and the reflected component of the pulse wave, and the pulse wave amplitude deriving function to find the amplitudes of the pulse wave that correspond to the reference times for the identification of the ejection wave component and the reflected component.
  • the velocity of the pulse wave is then calculated by the pulse wave velocity deriving function on basis of the reference times for the identification of the ejection wave component and the reflected component and the amplitudes of the pulse wave that correspond to the reference times for the identification of the ejection wave component and the reflected component.
  • the pulse wave velocity can be detected with higher accuracy in consideration of the difference between the pulse wave velocities of the ejection wave and the reflected wave which difference is caused by a difference between the amplitude of the ejection wave component and the amplitude of the reflected wave component.
  • the pulse wave amplitude deriving function includes an ejection wave component eliminating function of finding an ejection wave component included in the amplitude of the pulse wave that corresponds to the reference time for the reflected wave component, eliminating the ejection wave component included in the amplitude of the pulse wave from the amplitude of the pulse wave that corresponds to the reference time for the reflected wave component, and thereby finding an amplitude of the reflected wave component that corresponds to the reference time for the reflected wave component, and
  • the pulse wave velocity deriving function comprises calculating the velocity of the pulse wave on basis of the reference time for the ejection wave component, the reference time for the reflected wave component, the amplitude of the pulse wave that corresponds to the reference time for the ejection wave component, and the amplitude of the reflected wave component that has been found by the ejection wave component eliminating function.
  • the ejection wave component included in the amplitude of the pulse wave is eliminated by the ejection wave component eliminating function from the amplitude of the pulse wave that corresponds to the reference time for the reflected wave component, and the amplitude of the reflected wave component that corresponds to the reference time for the reflected wave component is thereby found.
  • the amplitude of the reflected wave component that corresponds to the reference time for the reflected wave component can more accurately be found. Therefore, the velocity of the pulse wave can more accurately be found by the pulse wave velocity deriving function.
  • the pulse wave velocity deriving function comprises finding the velocity of the pulse wave on basis of a time difference between the reference time for the ejection wave component and the reference time for the reflected wave component, and an amplitude difference between the amplitude of the pulse wave that corresponds to the reference time for the ejection wave component and the amplitude of the reflected wave component that has been found by the ejection wave component eliminating function.
  • the velocity of the pulse wave can accurately be found on basis of the time difference between the reference time for the ejection wave component and the reference time for the reflected wave component and the amplitude difference between the amplitude of the pulse wave that corresponds to the reference time for the ejection wave component and the amplitude of the reflected wave component that has been found by the ejection wave component eliminating function.
  • the pulse wave velocity is found on basis of the reference times for the identification of the ejection wave component and the reflected component and the amplitudes of the pulse wave that correspond to the reference times for the identification of the ejection wave component and the reflected component, and thus the pulse wave velocity can be detected with high accuracy in consideration of the difference between the pulse wave velocities of the ejection wave and the reflected wave which difference is caused by the difference between the amplitude of the ejection wave component and the amplitude of the reflected wave component.
  • FIG. 1 is a block diagram of a pulse wave velocity measurement device that is an embodiment of the invention
  • FIG. 2A is a waveform chart showing a waveform of a pulse wave detected by a pulse wave detection unit in the embodiment
  • FIG. 2B is a waveform chart showing a waveform of an acceleration wave of the pulse wave
  • FIG. 2C is a waveform chart showing a waveform of a third derivative of the pulse wave detected by the pulse wave detection unit in the embodiment
  • FIG. 2D is a waveform chart showing a waveform of a fourth derivative of the pulse wave
  • FIG. 3 is a waveform chart showing a waveform of the pulse wave and amplitudes W 1 , W 2 of the pulse wave at reference points Q 1 , Q 2 of the pulse wave;
  • FIG. 4 is a waveform chart showing a waveform of the pulse wave, and an ejection wave component S 1 and a reflected wave component S 2 of the pulse wave;
  • FIG. 5 is a schematic diagram that schematically shows a path d through which the ejection wave component S 1 of the pulse wave S propagates in a human living body and a path h through which the reflected wave component S 2 propagates in the human living body.
  • FIG. 1 is a block diagram showing a pulse wave velocity measurement device 10 that is an embodiment of the invention.
  • the pulse wave velocity measurement device 10 includes a pulse wave detection unit 1 that detects pulse waves at one site in a living human body.
  • the pulse wave detection unit 1 may be, for instance, a unit in which a degree of reflection or absorption of infrared light outputted from a light emitting device according to a quantity of blood in a blood vessel is measured by a light receiving device (photoplethysmography).
  • the pulse wave detection unit 1 may be used a unit that detects pulse waves by pressure pulse wave method in which a change in pressure of blood in a blood vessel against the blood vessel is extracted as electric signals.
  • the site is desirably set at a site noninvasive and unconstrained, if possible, and is preferably set on a finger tip, a wrist, an earlobe or the like.
  • the pulse wave velocity measurement device 10 includes an ejection and reflected waves information extraction unit 6 for detecting reference times for identification of an ejection wave component and a reflected wave component that are included in the pulse wave detected by the pulse wave detection unit 1 and amplitudes of the pulse wave that correspond to the reference times, and a pulse wave velocity detection unit 5 for finding a velocity of the pulse wave on basis of information representing the reference time and the amplitudes that is sent from the ejection and reflected waves information extraction unit 6 .
  • the ejection and reflected waves information extraction unit 6 includes a reference time detection unit 2 for detecting the reference time for the identification of the ejection wave component included in the pulse wave detected by the pulse wave detection unit 1 and the reference time for identification of the reflected wave component included in the pulse wave.
  • FIG. 2A shows an example of a waveform of a pulse wave detected by the pulse wave detection unit 1 .
  • a vertical axis in FIG. 2A represents measured voltage values (V) corresponding to amplitudes (mmHg) of the pulse wave.
  • correction (calibration) of correspondence of the voltage values (V) measured by the pulse wave detection unit 1 with the amplitudes (mmHg) of the pulse wave is performed on basis of blood pressures (mmHg) measured by a conventional cuff-type sphygmomanometer, as an example.
  • the correction (calibration) has only to be performed when first use thereof is started, and a result of the calibration has only to be used for the subsequent measurement.
  • the reference time detection unit 2 detects time T 1 , at a maximum point Q 1 in a systole in a waveform of the pulse wave shown in FIG. 2A , as reference time T 1 for the ejection wave component.
  • FIG. 2B shows an acceleration wave of the pulse wave
  • FIG. 2C shows a third derivative of the pulse wave.
  • the reference time detection unit 2 detects a third zero cross point Q 2 of a fourth derivative of the pulse wave shown in FIG. 2D , as reference time T 2 for the reflected wave component.
  • the third zero cross point Q 2 signifies a point where the fourth derivative waveform shown in FIG. 2D crosses zero downward at the third time after the pulse wave shown in FIG. 2A passes the minimum value.
  • the reference time for the ejection wave component of the pulse wave and the reference time for the reflected wave component thereof can more preferably be determined may be employed, if any, on condition that the detected pulse waves have a waveform other than Type C in the blood pressure waveform classification.
  • pulse waves do not exhibit so great change in waveform unless there is great fluctuation in the blood pressure, and thus an accuracy in detecting a pulse wave can be improved by superimposition (arithmetic mean) of a plurality of measured pulse waves.
  • Pulse waves exhibit various waveforms according to noise levels, ages, sex, presence or absence of illness, physical conditions, and the like, and thus a method by which the reference time for the ejection wave component of the pulse waves and the reference time for the reflected wave component thereof can more preferably be determined may be employed. For instance, an accuracy in determining the reference time for the ejection wave component of the pulse wave and the reference time for the reflected wave component thereof can be improved by recording, as a history, of the detected pulse waves along with conditions of a measured person at that point of time.
  • the ejection and reflected waves information extraction unit 6 includes a pulse wave amplitude detection unit 3 .
  • the pulse wave amplitude detection unit 3 detects an amplitude W 1 of the pulse wave S that corresponds to the reference time T 1 for the ejection wave component detected by the reference time detection unit 2 and detects an amplitude W 2 of the pulse wave S that corresponds to the reference time T 2 for the reflected wave component detected by the reference time detection unit 2 .
  • the ejection and reflected waves information extraction unit 6 further includes an ejection wave component elimination unit 4 .
  • the ejection wave component elimination unit 4 eliminates an ejection wave component S 1 of the pulse wave S from the amplitude W 2 of the pulse wave S, which amplitude corresponds to the reference time T 2 for the reflected wave component S 2 and thereby finds an amplitude W 3 of the reflected wave component S 2 , that corresponds to the reference time T 2 for the reflected wave component S 2 .
  • the ejection and reflected waves information extraction unit 6 inputs into the pulse wave velocity detection unit 5 information representing the reference time T 1 for the ejection wave component and the reference time T 2 for the reflected wave component detected by the reference time detection unit 2 and inputs into the pulse wave velocity detection unit 5 information representing the amplitude W 1 of the pulse wave S and the amplitude W 3 of the reflected wave component S 2 of the pulse wave S that have been detected by the pulse wave amplitude detection unit 3 and that correspond to the reference time T 1 for the ejection wave component and the reference time T 2 for the reflected wave components, respectively.
  • the pulse wave velocity detection unit 5 finds the velocity of the pulse wave S on basis of the reference time T 1 for the ejection wave component, the reference time T 2 for the reflected wave component, the amplitude W 1 of the pulse wave S that corresponds to the reference time T 1 for the ejection wave component, and the amplitude W 3 of the reflected wave component S 2 of the pulse wave S that corresponds to the reference time T 2 for the reflected wave component S 2 .
  • pulse wave velocity in general, pulse waves at two sites in a living body are measured and a velocity at which the ejection wave component of the pulse waves is propagated is found by a fundamental principle that is based on the principle of Moens-Korteweg.
  • a relation between the pulse wave velocity and the blood pressure is derived from the relation of Moens-Korteweg and is expressed as the following equation (1).
  • PWV is the pulse wave velocity (m/sec)
  • P is the blood pressure (mmHg)
  • a and ⁇ are constants that slightly change among individuals and according to measurement time even in an individual.
  • W 1 is the pulse wave amplitude of the ejection wave S 1 , that is, the amplitude W 1 of the pulse wave S that corresponds to the reference time T 1 for the ejection wave S 1 of FIG. 4 , and the amplitude W 1 corresponds to a pulse wave pressure of the ejection wave Sl.
  • W 3 therein is the pulse wave amplitude of the reflected wave S 2 , that is, the amplitude W 3 of the reflected wave S 2 that corresponds to the reference time T 2 for the reflected wave S 2 of FIG. 4 , and the amplitude W 3 corresponds to a pulse wave pressure of the reflected wave S 2 .
  • Equation (4) and (5) are obtained with a distance from a heart 51 of a human body to a pulse wave measurement site 52 designated by d (m), a distance from the heart 51 to a reflection point 53 designated by h (m), a time period between a pulsation of the heart 51 and the reference time T 1 for the ejection wave S 1 designated by ⁇ T 1 (sec), and a time difference (T 2 ⁇ T 1 ) between the reference time T 1 for the ejection wave S 1 and the reference time T 2 for the reflected wave S 2 designated by ⁇ T 2 (sec), as shown in FIG. 5 .
  • the time ⁇ T 1 can be eliminated from the equations (6) and (7). That is, the following equation (8) is obtained from the equation (7).
  • the pulse wave velocity detection unit 5 finds the pulse wave velocity PWV 1 of the ejection wave S 1 of the pulse wave S, by the equation (9) derived from the equations (4) through (7) described above, on basis of the difference ⁇ T 2 between the reference times T 1 and T 2 for the ejection wave component S 1 and the reflected component S 2 , and the amplitudes W 1 , W 3 of the ejection wave component S 1 and the reflected component S 2 of the pulse wave S.
  • the pulse wave velocity can be measured with high accuracy in consideration of a difference between the pulse wave velocities of the ejection wave and the reflected wave which difference is caused by a difference between the amplitude W 3 of the ejection wave component S 1 and the amplitude W 3 of the reflected wave component S 2 .
  • the pulse wave amplitude detection unit 3 includes the ejection wave component elimination unit 4
  • the following equation 10 in which the amplitude W 3 of the reflected wave S 2 that corresponds to the reference time T 2 for the reflected wave S 2 in the equation (3) is replaced by the amplitude W 2 of the pulse wave S that corresponds to the reference time T 2 for the reflected wave S 2 is used providing that the pulse wave amplitude detection unit 3 does not include the ejection wave component elimination unit 4 .
  • the pulse wave velocity detection unit 5 finds the pulse wave velocity PWV 1 of the ejection wave S 1 of the pulse wave S, by the equation (13) derived as described above, on basis of the difference ⁇ T 2 between the reference times T 1 and T 2 for the ejection wave component Si and the reflected component S 2 , and the amplitude W 2 of the pulse wave S at the reference time T 2 that corresponds to the reference time T 2 for the reflected wave component S 2 .
  • the pulse wave velocity can be measured with high accuracy in consideration of the difference between the pulse wave velocities of the ejection wave S 1 and the reflected wave S 2 of the pulse wave S.
  • a blood pressure can be measured on basis of the pulse wave velocity measured in the embodiment, as apparent from the equation (1). That is, the pulse wave velocity found by the pulse wave velocity measurement device may be displayed as a blood pressure, instead of being displayed as it is, when a user uses the pulse wave velocity measurement device. That is because the blood pressure is a living-body index that is more familiar to people other than medical personnel than the pulse wave velocity though the pulse wave velocity is a living-body index that is extremely familiar to medical personnel.
  • a conventional sphygmomanometer using a cuff presents to a user a set composed of a systolic blood pressure, a diastolic blood pressure, a mean blood pressure, a pulse rate, and the like with use of several tens of seconds, whereas a sphygmomanometer based on the embodiment of the invention is capable of detecting a blood pressure for each pulsation and thus brings about a possibility that conditions of a living body can more minutely be grasped. Besides, the pulse wave velocity and the blood pressure can be detected thereby with higher accuracy by acquisition of an arithmetic mean, a moving average and/or the like of a unit of several pulsations.
  • a computer may be made to execute a reference time deriving function of the reference time detection unit 2 finding the reference times T 1 and T 2 , a pulse wave amplitude deriving function of the pulse wave amplitude detection unit 3 finding the amplitudes W 1 , W 2 of the pulse wave S that correspond to the reference times T 1 , T 2 , an ejection wave component eliminating function of the ejection wave component elimination unit 4 finding the amplitude W 3 of the reflected wave component S 2 that corresponds to the reference time T 2 for the reflected wave component S 2 , a function of the pulse wave velocity detection unit 5 finding the pulse wave velocity PWV 1 of the ejection wave S 1 of the pulse wave S on basis of the difference ⁇ T 2 between the reference times T 1 and T 2 for the ejection wave component S 1 and the reflected component S 2 and the amplitudes W 3 of the reflected component S 2 of the pulse wave S that corresponds to the reference time T 2 for the reflected wave component S 2 , as described
  • the computer may be made to execute the reference time deriving function of the reference time detection unit 2 finding the reference times T 1 and T 2 , the pulse wave amplitude deriving function of the pulse wave amplitude detection unit 3 finding the amplitudes W 1 , W 2 of the pulse wave S that correspond to the reference times T 1 , T 2 , and a function of the pulse wave velocity detection unit 5 finding the pulse wave velocity PWV 1 of the ejection wave S 1 of the pulse wave S on basis of the difference ⁇ T 2 between the reference times T 1 and T 2 for the ejection wave component S 1 and the reflected component S 2 and the amplitude W 2 of the pulse wave S that corresponds to the reference time T 2 for the reflected wave component S 2 , as described above.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
US13/508,933 2009-11-10 2010-11-01 Pulse wave velocity measurement device and pulse wave velocity measurement program Abandoned US20120226174A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009-257217 2009-11-10
JP2009257217A JP5328613B2 (ja) 2009-11-10 2009-11-10 脈波伝播速度測定装置および脈波伝播速度測定プログラム
PCT/JP2010/069408 WO2011058900A1 (ja) 2009-11-10 2010-11-01 脈波伝播速度測定装置および脈波伝播速度測定プログラム

Publications (1)

Publication Number Publication Date
US20120226174A1 true US20120226174A1 (en) 2012-09-06

Family

ID=43991559

Family Applications (1)

Application Number Title Priority Date Filing Date
US13/508,933 Abandoned US20120226174A1 (en) 2009-11-10 2010-11-01 Pulse wave velocity measurement device and pulse wave velocity measurement program

Country Status (5)

Country Link
US (1) US20120226174A1 (zh)
EP (1) EP2499967B1 (zh)
JP (1) JP5328613B2 (zh)
CN (1) CN102711597B (zh)
WO (1) WO2011058900A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112515629A (zh) * 2019-09-19 2021-03-19 三星电子株式会社 用于估计生物信息的设备

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104635110A (zh) * 2015-01-23 2015-05-20 昆明理工大学 一种基于实测数据的波速校核方法
CN104720777B (zh) * 2015-03-10 2017-11-03 中国科学院电子学研究所 一种无创连续血压生理监测系统
KR102501837B1 (ko) * 2015-11-09 2023-02-21 삼성전자주식회사 신호 특징 추출 방법 및 장치
GB2552455B8 (en) * 2016-06-16 2022-06-15 Digital & Future Tech Limited Blood monitoring
TWI644651B (zh) * 2017-11-17 2018-12-21 國立成功大學 訊號同步處理裝置及具有訊號同步處理功能的聽診器、聽診資訊輸出系統與病徵診斷系統
DE102018209198B3 (de) * 2018-06-08 2019-08-29 Gert Küchler Verfahren und Gerät zur Bestimmung mindestens eines physiologischen Parameters
CN110960199B (zh) * 2019-12-24 2022-05-27 中国人民解放军陆军军医大学第一附属医院 一种双变量测量动脉硬化程度的系统

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030004420A1 (en) * 2001-07-02 2003-01-02 Colin Corporation Pulse-wave-propagation-velocity-related-information obtaining apparatus
US20050283086A1 (en) * 2004-06-14 2005-12-22 Omron Healthcare Co., Ltd. Pulse wave analysis apparatus and pulse wave analysis program product for automatically extracting characteristic points of pulse wave

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3533406B2 (ja) * 2001-07-02 2004-05-31 コーリンメディカルテクノロジー株式会社 動脈硬化評価装置
JP3621379B2 (ja) * 2002-01-09 2005-02-16 コーリンメディカルテクノロジー株式会社 動脈硬化評価装置
JP3616061B2 (ja) * 2002-03-01 2005-02-02 コーリンメディカルテクノロジー株式会社 動脈硬化検査装置
JP3643567B2 (ja) * 2002-04-17 2005-04-27 コーリンメディカルテクノロジー株式会社 振幅増加指数測定装置
JP2003305011A (ja) * 2002-04-17 2003-10-28 Nippon Colin Co Ltd 振幅増加指数測定装置
JP3587837B2 (ja) * 2002-09-27 2004-11-10 コーリンメディカルテクノロジー株式会社 動脈硬化度評価装置
JP4517619B2 (ja) * 2002-12-05 2010-08-04 オムロンヘルスケア株式会社 脈波測定装置
HU0400426D0 (en) * 2004-02-18 2004-04-28 Illyes Miklos Dr Apparatus and method for measurement of dynamic characteristic of blood and for complex monitoring of circulatory system
DE602005012204D1 (de) * 2004-02-18 2009-02-26 Miklos Illyes Gerät und verfahren zur messung von hämodynamischen parametern
JP2006043146A (ja) * 2004-08-04 2006-02-16 Sony Corp 脈波解析方法及び装置
JP4855721B2 (ja) * 2005-06-29 2012-01-18 フクダ電子株式会社 血圧測定装置
US8273030B2 (en) * 2005-12-01 2012-09-25 Atcor Medical Pty Ltd Method of estimating pulse wave velocity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030004420A1 (en) * 2001-07-02 2003-01-02 Colin Corporation Pulse-wave-propagation-velocity-related-information obtaining apparatus
US20050283086A1 (en) * 2004-06-14 2005-12-22 Omron Healthcare Co., Ltd. Pulse wave analysis apparatus and pulse wave analysis program product for automatically extracting characteristic points of pulse wave

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112515629A (zh) * 2019-09-19 2021-03-19 三星电子株式会社 用于估计生物信息的设备
US20210085259A1 (en) * 2019-09-19 2021-03-25 Samsung Electronics Co., Ltd. Apparatus and method for estimating bio-information

Also Published As

Publication number Publication date
WO2011058900A1 (ja) 2011-05-19
JP5328613B2 (ja) 2013-10-30
JP2011101696A (ja) 2011-05-26
CN102711597A (zh) 2012-10-03
EP2499967A1 (en) 2012-09-19
EP2499967A4 (en) 2013-08-21
CN102711597B (zh) 2015-09-30
EP2499967B1 (en) 2014-06-25

Similar Documents

Publication Publication Date Title
EP2554111A1 (en) Pulse wave velocity measurement device, pulse wave velocity measurement method and pulse wave velocity measurement program
US20120226174A1 (en) Pulse wave velocity measurement device and pulse wave velocity measurement program
Ibrahim et al. Cuffless blood pressure monitoring from an array of wrist bio-impedance sensors using subject-specific regression models: Proof of concept
EP3157416B1 (en) System for cuff-less blood pressure (bp) measurement of a subject
JP2021519621A (ja) フォトプレチスモグラフィック（ｐｐｇ）シグナルに基づいて血圧および動脈壁の硬化を推定する方法
Barvik et al. Noninvasive continuous blood pressure estimation from pulse transit time: A review of the calibration models
US20200000349A1 (en) Pulse detection module and use-as-you-need blood pressure measurement device comprising the same
Sola et al. Chest pulse-wave velocity: A novel approach to assess arterial stiffness
US20140148702A1 (en) Method, device and system for determining the open/closed switch moment of an artery of interest under a changing pressure
JP5573550B2 (ja) 血圧情報測定装置および血圧情報測定方法
US11154208B2 (en) System and method of measurement of average blood pressure
CN104042200B (zh) 一种逐拍动脉血压的无创监测装置及其方法
US20120172734A1 (en) Blood pressure manometer and a method of calculating indices of atherosclerosis using the blood pressure manometer
EP2598022A1 (en) Diagnostic support apparatus
CN115135236A (zh) 改进的个人健康数据收集
Rasool et al. Continuous and noninvasive blood pressure estimation by two-sensor measurement of pulse transit time
JP5681434B2 (ja) 脈波伝播速度測定装置および脈波伝播速度測定プログラム
Paliakaitė et al. Blood pressure estimation based on photoplethysmography: Finger versus wrist
Joseph et al. Arterial compliance probe for calibration free pulse pressure measurement
JP2011104208A (ja) 脈波伝播速度測定装置
JP2011182968A (ja) 血圧情報測定装置および該装置での動脈硬化度の指標の算出方法
Sameen et al. A novel waveform mirroring technique for systolic blood pressure estimation from anacrotic photoplethysmogram
KR101918577B1 (ko) 혈압계 및 이를 이용한 혈압 측정 방법
JP5690550B2 (ja) 脈波伝播速度測定装置
Qawqzeh et al. Photoplethysmogram reflection index and aging

Legal Events

Date Code Title Description
AS Assignment

Owner name: SHARP KABUSHIKI KAISHA, JAPAN

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:IKEDA, YUTAKA;HORI, ATSUSHI;REEL/FRAME:028190/0744

Effective date: 20120307

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION