US20110214995A1 - Method for Making Radioactive Isotopic Gallium-67 - Google Patents
Method for Making Radioactive Isotopic Gallium-67 Download PDFInfo
- Publication number
- US20110214995A1 US20110214995A1 US12/718,826 US71882610A US2011214995A1 US 20110214995 A1 US20110214995 A1 US 20110214995A1 US 71882610 A US71882610 A US 71882610A US 2011214995 A1 US2011214995 A1 US 2011214995A1
- Authority
- US
- United States
- Prior art keywords
- gallium
- zinc
- solution
- solid target
- isotopic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- GYHNNYVSQQEPJS-OIOBTWANSA-N Gallium-67 Chemical compound [67Ga] GYHNNYVSQQEPJS-OIOBTWANSA-N 0.000 title claims abstract description 35
- 229940006110 gallium-67 Drugs 0.000 title claims abstract description 34
- 230000000155 isotopic effect Effects 0.000 title claims abstract description 16
- 238000000034 method Methods 0.000 title claims abstract description 14
- 230000002285 radioactive effect Effects 0.000 title claims abstract description 13
- HCHKCACWOHOZIP-AKLPVKDBSA-N zinc-68 Chemical compound [68Zn] HCHKCACWOHOZIP-AKLPVKDBSA-N 0.000 claims abstract description 29
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000007787 solid Substances 0.000 claims abstract description 13
- 239000002253 acid Substances 0.000 claims abstract description 6
- GYHNNYVSQQEPJS-YPZZEJLDSA-N Gallium-68 Chemical compound [68Ga] GYHNNYVSQQEPJS-YPZZEJLDSA-N 0.000 claims abstract description 5
- 238000009713 electroplating Methods 0.000 claims abstract description 4
- 239000011347 resin Substances 0.000 claims abstract description 4
- 229920005989 resin Polymers 0.000 claims abstract description 4
- HCHKCACWOHOZIP-IGMARMGPSA-N Zinc-65 Chemical compound [65Zn] HCHKCACWOHOZIP-IGMARMGPSA-N 0.000 claims abstract description 3
- 150000002500 ions Chemical class 0.000 claims abstract description 3
- 238000001704 evaporation Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 abstract description 5
- 239000006200 vaporizer Substances 0.000 abstract 1
- 238000005342 ion exchange Methods 0.000 description 4
- 238000004064 recycling Methods 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- GYHNNYVSQQEPJS-AHCXROLUSA-N gallium-66 Chemical compound [66Ga] GYHNNYVSQQEPJS-AHCXROLUSA-N 0.000 description 1
- 238000009206 nuclear medicine Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000013110 organic ligand Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000002603 single-photon emission computed tomography Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25C—PROCESSES FOR THE ELECTROLYTIC PRODUCTION, RECOVERY OR REFINING OF METALS; APPARATUS THEREFOR
- C25C1/00—Electrolytic production, recovery or refining of metals by electrolysis of solutions
- C25C1/22—Electrolytic production, recovery or refining of metals by electrolysis of solutions of metals not provided for in groups C25C1/02 - C25C1/20
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P10/00—Technologies related to metal processing
- Y02P10/20—Recycling
Definitions
- the present disclosure relates to a method for making radioactive isotopic gallium-67 and, more particularly, to a method for rapidly filtering pure gallium-67 liquid.
- Gallium-67 ( 67 Ga) is a radioactive isotope produced by a cyclotron.
- SPECT single photon emission computerized tomography
- Substantial nuclear reaction in the production of gallium-67 includes 68 Zn (p, 2n), 67 Zn (d, 2n) and 65 Cu ( ⁇ , 2n).
- the yield of the production of gallium-67 is highest if high-concentration zinc-68 (higher than 97%) with proper thickness (0 to 100 ⁇ m) is used as a target subject to proper proton irradiation (0 to 22 Mev).
- carrier-free gallium-67 chloride and citrate are provided.
- the carrier-free gallium-67 chloride and citrate can be combined with other organic ligands and turned into nuclear medicine for medical treatment.
- the radioactive isotopes cannot be produced in Taiwan, and all of the gallium-68 necessary for the production of the nuclear medical citrate is imported difficultly, expensively.
- the present disclosure is therefore intended to obviate or at least alleviate the problems encountered in prior art.
- isotopic zinc-68 is turned into a zinc-68 solid target by disposition or electroplating. Then, the zinc-68 solid target is subjected to proton irradiation. The irradiated zinc-68 solid target is dissolved in strong acid and turned into solution that contains zinc-65, zinc-68, gallium-67 and gallium-68. Hydrochloric acid and resin are added into the solution for exchange of ions. Zinc-68 solution and gallium-67 solution are separated from the solution by filtering. The gallium-67 solution is evaporated, thus providing radioactive isotopic gallium-67.
- FIG. 1 is a flow chart of a method for making radio isotopic gallium-67 according to the preferred embodiment of the present disclosure.
- FIG. 2 is a scheme of equipment used in the method shown in FIG. 1 to make radio isotopic gallium-67.
- FIG. 1 there is shown a method for making radioactive isotopic gallium-67 according to the preferred embodiment of the present disclosure.
- FIG. 2 there is shown equipment used in the method to make radioactive isotopic gallium-67.
- the equipment includes a dissolving unit 2 , an ion-exchange column 3 , a zinc-68 solution-recycling unit 31 , a waste liquid-recycling unit 32 and an evaporation unit 4 .
- zinc-68 is turned into a zinc-68 solid target 21 by electroplating.
- the zinc-68 solid target 21 is subjected to proton irradiation in a cyclotron (not shown).
- the intensity of the proton irradiation in the cyclotron is 15 to 40 MeV.
- the irradiated zinc-68 solid target 21 is dissolved in strong acid in the dissolving unit 2 .
- the strong acid can be hydrochloric acid with concentration of 8N to 12N and preferably 9N.
- the gallium-67 solution is heated in an evaporation unit 4 , so that the hydrochloric acid is evaporated and then radioactive isotopic gallium-67 is made.
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Electrochemistry (AREA)
- Organic Chemistry (AREA)
- Metallurgy (AREA)
- Materials Engineering (AREA)
- Physics & Mathematics (AREA)
- High Energy & Nuclear Physics (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Manufacture And Refinement Of Metals (AREA)
- Electrolytic Production Of Metals (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
Disclosed is a method for making carrier-free radioactive isotopic gallium-67. Stable isotopic zinc-68 is turned into zinc-68 solid target by disposition or electroplating. Then, the zinc-68 solid target is subjected to a proton beam. A cyclotron is used to provide irradiation from 15 to 40 MeV. After the irradiation, the zinc-68 solid target is dissolved in concentrated acid and turned into solution that contains zinc-65, zinc-68, gallium-67 and gallium-68. High concentrated hydrochloric acid and resin are added into the solution for exchange of ions. Zinc-68 liquid and gallium-67 liquid are filtered and separated from the solution. Thus, pure gallium-67 liquid is produced. With a vaporizer, the gallium-67 liquid is vaporized and turned into radioactive isotopic gallium-67.
Description
- The present disclosure relates to a method for making radioactive isotopic gallium-67 and, more particularly, to a method for rapidly filtering pure gallium-67 liquid.
- Gallium-67 (67Ga) is a radioactive isotope produced by a cyclotron. The nuclear properties of gallium-67 are short half life (t1/2=78 h) and medium energy (E.C.=100%, Er=93 KeV (38%), 185 KeV (23.6%) and 300 KeV (19%)). Therefore, gallium-67 is often used in single photon emission computerized tomography (“SPECT”) for human organs. Substantial nuclear reaction in the production of gallium-67 includes 68Zn (p, 2n), 67Zn (d, 2n) and 65Cu (α, 2n). The yield of the production of gallium-67 is highest if high-concentration zinc-68 (higher than 97%) with proper thickness (0 to 100 μm) is used as a target subject to proper proton irradiation (0 to 22 Mev). By dissolving the irradiated target and chemical separation, carrier-free gallium-67 chloride and citrate are provided. The carrier-free gallium-67 chloride and citrate can be combined with other organic ligands and turned into nuclear medicine for medical treatment. However, the radioactive isotopes cannot be produced in Taiwan, and all of the gallium-68 necessary for the production of the nuclear medical citrate is imported difficultly, expensively.
- The present disclosure is therefore intended to obviate or at least alleviate the problems encountered in prior art.
- It is the primary objective of the present disclosure to provide a method for making radioactive isotopic gallium-67.
- To achieve the foregoing objective, isotopic zinc-68 is turned into a zinc-68 solid target by disposition or electroplating. Then, the zinc-68 solid target is subjected to proton irradiation. The irradiated zinc-68 solid target is dissolved in strong acid and turned into solution that contains zinc-65, zinc-68, gallium-67 and gallium-68. Hydrochloric acid and resin are added into the solution for exchange of ions. Zinc-68 solution and gallium-67 solution are separated from the solution by filtering. The gallium-67 solution is evaporated, thus providing radioactive isotopic gallium-67.
- Other objectives, advantages and features of the present disclosure will be apparent from the following description referring to the attached drawings.
- The present disclosure will be described via detailed illustration of the preferred embodiment referring to the drawings wherein:
-
FIG. 1 is a flow chart of a method for making radio isotopic gallium-67 according to the preferred embodiment of the present disclosure; and -
FIG. 2 is a scheme of equipment used in the method shown inFIG. 1 to make radio isotopic gallium-67. - Referring to
FIG. 1 , there is shown a method for making radioactive isotopic gallium-67 according to the preferred embodiment of the present disclosure. Referring toFIG. 2 , there is shown equipment used in the method to make radioactive isotopic gallium-67. The equipment includes a dissolving unit 2, an ion-exchange column 3, a zinc-68 solution-recycling unit 31, a waste liquid-recycling unit 32 and an evaporation unit 4. - At 11, zinc-68 is turned into a zinc-68
solid target 21 by electroplating. - At 12, the zinc-68
solid target 21 is subjected to proton irradiation in a cyclotron (not shown). The intensity of the proton irradiation in the cyclotron is 15 to 40 MeV. - At 13, the irradiated zinc-68
solid target 21 is dissolved in strong acid in the dissolving unit 2. Thus, there is provided solution containing zinc-68, gallium-66, gallium-67 and gallium-68. The strong acid can be hydrochloric acid with concentration of 8N to 12N and preferably 9N. - At 14, some of the solution is filled in the ion-exchange column 3. Hydrochloric acid, with concentration of 8N to 12N and preferably 9N, and resin are filled in the ion-exchange column 3 for ion exchange. Gallium-67 solution 41 is absorbed. Zinc-68
solution 311 is sent into the zinc-68 solution-recycling bottle 31. Low-concentration solution 32 is transferred into the waste liquid-recycling unit 32. - At 15, the gallium-67 solution is heated in an evaporation unit 4, so that the hydrochloric acid is evaporated and then radioactive isotopic gallium-67 is made.
- The present disclosure has been described via the detailed illustration of the preferred embodiment. Those skilled in the art can derive variations from the preferred embodiment without departing from the scope of the present disclosure. Therefore, the preferred embodiment shall not limit the scope of the present disclosure defined in the claims.
Claims (4)
1. A method for making carrier-free radioactive isotopic gallium-67, the method comprising the steps of:
turning isotopic zinc-68 into a zinc-68 solid target by electroplating;
subjecting the zinc-68 solid target to proton irradiation;
dissolving the zinc-68 solid target in strong acid, thus providing solution that contains zinc-65, zinc-68, gallium-67 and gallium-68;
adding hydrochloric acid and resin in the solution for exchange of ions;
filtering the solution, thus providing zinc-68 solution and gallium-67 solution; and
evaporating the gallium-67 solution, thus providing radioactive isotopic gallium-67.
2. The method according to claim 1 , wherein the intensity of the proton irradiation is 15 to 40 MeV.
3. The method according to claim 1 , wherein the strong acid used to dissolve the zinc-68 solid target is hydrochloric acid with concentration of 8N to 12N.
4. The method according to claim 1 , wherein the concentration of the hydrochloric acid added in the solution is 8N to 12N.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/718,826 US20110214995A1 (en) | 2010-03-05 | 2010-03-05 | Method for Making Radioactive Isotopic Gallium-67 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/718,826 US20110214995A1 (en) | 2010-03-05 | 2010-03-05 | Method for Making Radioactive Isotopic Gallium-67 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US20110214995A1 true US20110214995A1 (en) | 2011-09-08 |
Family
ID=44530366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US12/718,826 Abandoned US20110214995A1 (en) | 2010-03-05 | 2010-03-05 | Method for Making Radioactive Isotopic Gallium-67 |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US20110214995A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016197084A1 (en) * | 2015-06-05 | 2016-12-08 | Ncm Usa Bronx Llc | Method and system for producing gallium-68 radioisotope by solid targeting in a cyclotrion |
| US10438712B2 (en) * | 2014-05-15 | 2019-10-08 | Mayo Foundation For Medical Education And Research | Solution target for cyclotron production of radiometals |
| WO2020048980A1 (en) * | 2018-09-03 | 2020-03-12 | Universitetet I Oslo | Process for the production of gallium radionuclides |
| US20200243210A1 (en) * | 2017-07-31 | 2020-07-30 | Stefan Zeisler | System, apparatus and method for producing gallium radioisotopes on particle accelerators using solid targets and ga-68 composition produced by same |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWM274044U (en) * | 2005-03-09 | 2005-09-01 | I-Feng Kao | Warm keeping vessel |
-
2010
- 2010-03-05 US US12/718,826 patent/US20110214995A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWM274044U (en) * | 2005-03-09 | 2005-09-01 | I-Feng Kao | Warm keeping vessel |
Non-Patent Citations (5)
| Title |
|---|
| Bonardi, M.L.; Groppi, F.; Birattari, C.; Gini, L.; Mainardi, C.; Ghioni, A.; Menapace, E.; Abbas, K.; Holzwarth, U.; Stroosnijder, M.F.: Journal of Radioanalytical and Nuclear Chemistry 257 (1) 2003, 229-241. * |
| El-Azony, K.M.; Ferieg, Kh.; Saleh, Z.A.: Direct separatoin of 67-Ga citrate fron zinc and copper target materials by anion exchange. Applied Radiation and Isotopes, 59, 2003, 329-331. * |
| Kakavand, T.; Sadeghi, M.; Mokhtari, L.; Majdabadi, A.: Zinc electrodeposition of copper substrate using cyanide bath for production of 66, 67, 68-Ga. Journal or Radioanalytical Nuclear Chemistry, 283, 2010, p. 197-201. * |
| Lewis, M.R.; Reichert, D.E.; Laforest, R.; Margenau, W.H.; Shefer, R.E.; Klinkowstein, R.E.' Hughey, B.J.; Welch, M.J.: Production and purification of gallium-66 for prepartion of tumor-targeting radiopharmaceuticals. Nuclear Medicine and Biology, 29, 2002, 701-706. * |
| Schlyer, D.J.: Production of Radionuclides in Accelerators. Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by M.J. Welch and C.S. Redvanly, Publisher: John Wiley and Sons, 2003, p. 1-70 with emphasis on pages 33-35. * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10438712B2 (en) * | 2014-05-15 | 2019-10-08 | Mayo Foundation For Medical Education And Research | Solution target for cyclotron production of radiometals |
| US10522261B2 (en) * | 2014-05-15 | 2019-12-31 | Mayo Foundation For Medical Education And Research | Solution target for cyclotron production of radiometals |
| US11266975B2 (en) | 2014-05-15 | 2022-03-08 | Mayo Foundation For Medical Education And Research | Solution target for cyclotron production of radiometals |
| WO2016197084A1 (en) * | 2015-06-05 | 2016-12-08 | Ncm Usa Bronx Llc | Method and system for producing gallium-68 radioisotope by solid targeting in a cyclotrion |
| US20200243210A1 (en) * | 2017-07-31 | 2020-07-30 | Stefan Zeisler | System, apparatus and method for producing gallium radioisotopes on particle accelerators using solid targets and ga-68 composition produced by same |
| WO2020048980A1 (en) * | 2018-09-03 | 2020-03-12 | Universitetet I Oslo | Process for the production of gallium radionuclides |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AS | Assignment |
Owner name: ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HUANG, SUN-RONG;TSAI, YING-MING;LU, JAINN-HSIN;AND OTHERS;SIGNING DATES FROM 20100121 TO 20100125;REEL/FRAME:024038/0522 |
|
| STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |