US20110178368A1 - Method for determining measured data from the stomach of a patient - Google Patents
Method for determining measured data from the stomach of a patient Download PDFInfo
- Publication number
- US20110178368A1 US20110178368A1 US13/056,394 US200913056394A US2011178368A1 US 20110178368 A1 US20110178368 A1 US 20110178368A1 US 200913056394 A US200913056394 A US 200913056394A US 2011178368 A1 US2011178368 A1 US 2011178368A1
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- US
- United States
- Prior art keywords
- stomach
- drink solution
- patient
- solution
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/041—Capsule endoscopes for imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00147—Holding or positioning arrangements
- A61B1/00158—Holding or positioning arrangements using magnetic field
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
- A61B1/2736—Gastroscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Definitions
- a variant that is more comfortable and gentle for the patient relative to classical gastroscopy uses a capsule endoscope that can be swallowed.
- the capsule endoscope/the endoscopy capsule is connected (for example via a radio connection) with a transmission station placed in proximity to the patient.
- the capsule endoscope can be magnetically navigable.
- This type of capsule endoscopy is also designated as MGCE (Engl.: magnetically guided capsule endoscopy).
- MGCE Magnetically guided capsule endoscopy
- a capsule endoscope that is suitable for this method arises from DE 101 42 253 C1, which was already mentioned.
- the stomach is expanded not with a gas but rather with the aid of a liquid.
- multiple measurement errors have been observed in the acquisition of measurement data.
- the gas bubble formation inside the stomach is particularly problematic for a magnetically navigable capsule endoscope.
- an adhesion of gas bubbles to the surface of the capsule leads to unwanted local buoyancy forces that can cause the capsule to tumble but at least significantly hinder its navigability.
- the aqueous drink solution according to the invention that is for use in a measurement method in which this is present in the stomach of a patient in additional to an endoscope for acquisition of measurement data is characterized in that this solution is degassed.
- the drink solution is freed of dissolved gases at least insofar as that a gas bubble development is nearly precluded when this is brought into the stomach of the patient.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endoscopes (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
In a method to obtain measurement data from the stomach of a patient using an endoscope, a degassed aqueous drink solution is administered to the stomach of the patient and the measurement data are acquired with the degassed aqueous drink solution present in the stomach.
Description
- 1. Field of the Invention
- The invention concerns a method to determine measurement data from the stomach of a patient, of the type wherein an endoscope is used to acquire measurement data in the stomach of a patient and an aqueous drink solution is present in the stomach of the patient. The invention moreover concerns a drink solution for the implementation of such a method.
- 2. Description of the Prior Art
- As used herein, an endoscope means both a generally known, classical endoscope which is brought into the stomach of a patient with the use of a tube directed through the mouth or nose of the patient, and a capsule endoscope (known for example from DE 101 42 253 C1) that the patient can independently swallow. A drink solution is a liquid provided for use in the field of medicine that is selectively brought into the stomach of a patient with a stomach probe or is administered to the patient for independent ingestion.
- An endoscopically implemented examination of the human or animal stomach—a gastroscopy—is part of a routine examination in everyday medical practice. Within the framework of the gastroscopy, different variables, measurement values or samples are taken inside the stomach and provided to a physician or assistant for evaluation. For example, content substances or concentrations of the stomach contents are measured, the chemical composition of the gastric juices are determined or image data of the stomach mucosa are collected.
- In classical endoscopy, a tube is directed through the mouth or nose of the patient into his stomach. Since the stomach is a hollow muscle, this is normally expanded by blowing in a gas (for example air or CO2), in particular for the implementation of visual examinations. As a result of this expansion, regions of the stomach that are otherwise covered by the mucosa folds are also accessible.
- A variant that is more comfortable and gentle for the patient relative to classical gastroscopy uses a capsule endoscope that can be swallowed. To transfer measurement data from inside the stomach, the capsule endoscope/the endoscopy capsule is connected (for example via a radio connection) with a transmission station placed in proximity to the patient. For targeted acquisition of measurement and/or image data from specific regions of the stomach, the capsule endoscope can be magnetically navigable. This type of capsule endoscopy is also designated as MGCE (Engl.: magnetically guided capsule endoscopy). For example, a capsule endoscope that is suitable for this method arises from DE 101 42 253 C1, which was already mentioned. In contrast to conventional gastroscopy, in capsule endoscopy the stomach is expanded not with a gas but rather with the aid of a liquid. However, multiple measurement errors have been observed in the acquisition of measurement data.
- An object of the invention is to provide a method to determine measurement data from inside the stomach which is improved with regard to its precision. The invention also encompasses a drink solution for application in such a method that allows an improved accuracy in the measurement value acquisition.
- In the method according to the invention an endoscope to acquire the measurement data is present in the stomach of the patient to obtain measurement data from said stomach.
- During the acquisition of the measurement data, an aqueous drink solution that is previously degassed is present in the stomach of the patient.
- As used herein, a degassed drink solution is a drink solution that is free of dissolved gases at least insofar as that gas bubble formation is nearly precluded when this is brought into the stomach of the patient. The conditions prevailing in the stomach of a patient are to be taken into account in this context. The drink solution is thus degassed at least insofar as that this no longer outgasses given the conditions prevailing in the stomach of the patient, for example with regard to temperature, pH value etc. A complete degassing of the drink solution is normally not necessary in this context.
- The method according to the invention is based on the following insight.
- The expansion of the stomach with the use of a liquid that is particularly advantageous for capsule endoscopy entails different technical problems. However, the following statements apply for both classical endoscopy and capsule endoscopy.
- For example, reactions can occur between the liquid used for the expansion and the stomach contents, in particular the gastric juices. The formation of gas bubbles has been observed multiple times in the chemical and/or physical interaction between the liquid and the stomach contents. A gas bubble development inside the stomach has been connected with the occurring measurement errors of the probes present in the endoscope.
- A bubble development is particularly critical for the acquisition of optical image data of the stomach mucosa. Finely distributed bubbles dissolved in the liquid used to expand the stomach reduce its optical quality and lead to a high proportion of scattered light in the image data. Moreover, bubbles adhering to the outside of the capsule can cause image errors since the optics used to acquire the image data are entirely or partially covered.
- The gas bubble formation inside the stomach is particularly problematic for a magnetically navigable capsule endoscope. For example, an adhesion of gas bubbles to the surface of the capsule leads to unwanted local buoyancy forces that can cause the capsule to tumble but at least significantly hinder its navigability.
- In summary, the bubble formation occurring in the stomach could be identified as a primary cause for arising measurement errors. To avoid the gas formation, the drink solution is degassed according to the invention. This measure is motivated by the following considerations.
- The drink solution that is transported into the stomach to expand it is in contact with both the stomach contents and the stomach mucosa. After the drink solution has been introduced into the stomach of the patient, various chemical reactions can occur between this and the stomach contents or, respectively, the gastric juices produced by the stomach mucosa. One example is the variation of the pH value of the drink solution due to the (typically acidic) gastric juices. If the pH value drops, the solubility of CO2 in water decreases, such that this outgasses. This and other reactions have been connected with a gas formation inside the stomach. An additional effect that leads to the gas bubble formation inside the stomach is the warming of the drink solution. In that the temperature of the drink solution increases—for example from room temperature or below this to the typical temperature of the stomach—the solubility of the gases present in the drink solution decreases, whereby these escape. In order to suppress the gas bubble formation that has been repeatedly observed, the drink solution is degassed before this is brought into the stomach of the patient. The drink solution is thus freed of dissolved gases at least insofar as that a gas bubble development is nearly precluded if said solution is brought into the stomach of the patient. Particular attention is thereby granted to the gases CO2, N2 and O2. These gases represent the primary components of ambient air and are correspondingly dissolved in drinking water, for example. The drink solution is advantageously predominantly freed of these gases.
- The gas bubble development that is suppressed in this manner has an advantageous effect on the precision of the measurement values detected with the endoscope. In conventional measurement methods that use a drink solution that has not been degassed, it has been repeatedly observed that gas bubbles adhere to the sensors of the endoscope and in this way cause severe measurement errors. In particular in the acquisition of optical image data, severe distortions occur in conventional measurement methods. For example, the drink solution can become turbid due to dissolved gas bubbles, such that the image data appear indistinct or exhibit a high proportion of scattered light.
- Both the determination of image data from inside the stomach of the patient and the determination of additional measurement data becomes significantly more reliable due to the degassing of the drink solution.
- The aqueous drink solution according to the invention that is for use in a measurement method in which this is present in the stomach of a patient in additional to an endoscope for acquisition of measurement data is characterized in that this solution is degassed. As has already been mentioned above, the drink solution is freed of dissolved gases at least insofar as that a gas bubble development is nearly precluded when this is brought into the stomach of the patient.
- Significant advantages of the drink solution according to the invention have already been cited in connection with the method according to the invention.
- In the following the invention is explained further using various exemplary embodiments.
- To prepare the measurement a degassed drink solution is administered to the patient. The drink solution can be independently taken by the patient, but it can also be brought into his stomach with a probe, for example. The fluid level in the stomach of the patient can be monitored with the aid of ultrasound. In order to compensate for an outflow of the drink solution from the stomach, during the implementation of the measurements drink solution can moreover be additionally drunk by the patient or be brought into his stomach in another manner.
- Within the scope of the preparation of the drink solution, according to a first exemplary embodiment this is subjected to a vacuum degassing before it is brought into the stomach of the patient. The vacuum degasing is easily controllable via technical measures and is inexpensive; it can possibly be supported via additional measures for degassing. For example, the drink solution can additionally be heated to expel the dissolved gases.
- Osmotic reactions at the stomach wall represent an additional source for the gas bubble formation inside the stomach. According to a further exemplary embodiment, these reactions can be suppressed via an isotonic preparation of the drink solution. The drink solution that is pre-treated in such a manner has the same osmotic pressure as human blood. Osmotic reactions at the stomach mucosa can thus be avoided. The gas bubble development inside the stomach can be prevented or at least can be severely reduced via the reduction or significant avoidance of such osmotic reactions at the stomach wall. The drink solution is preferably prepared isotonically via the addition of sodium chloride, i.e. is compounded with 0.9% by weight of cooking salt.
- Among other things, an additional problem in the acquisition of measurement data inside the human or animal stomach is foaming caused by the peristalsis of the stomach. Foam that is present in the stomach in particular hinders the acquisition of optical image data. This applies for both a conventional endoscope and for an endoscopy capsule. In the following reference is made to a capsule endoscope as an example.
- The endoscope possesses one or more cameras to acquire image data. In its working position the endoscopy capsule is located at or in proximity to the surface of the drink solution located in the stomach. The endoscopy capsule advantageously possesses multiple cameras, of which a first camera acquires optical data of the stomach mucosa through the drink solution from below the liquid level, for example. An additional camera can be arranged above the liquid level to acquire image data. In particular, the latter is significantly affected by foam formation inside the stomach.
- Foam present in the stomach hinders the acquisition of optical image data; however, other sensor that are possibly present at the endoscope can be disrupted by foam present in the stomach. To improve the working conditions of the endoscope inside the stomach, the drink solution is compounded with a defoaming agent, advantageously with a silicone oil. The use of silicone oil is particularly advantageous since this is physiologically harmless; silicone oil is inert inside the body, as is known from silicone implants. The addition of silicon oil produces a reduction of the surface tension of the drink solution provided in the stomach. This leads to a reduction of the foam formation.
- As already mentioned, in addition to optical image data the endoscope can also detect additional variables, for example concentrations of specific content substances present in the stomach. One example is the measurement of the ammonia content of the stomach contents. Ammonia exists as both NH3 and NH4 + in an aqueous environment. The equilibrium between NH3 and NH4 + shifts depending on the pH value prevailing in the stomach. To determine a significant measurement value of the NH3 concentration it is decisive that the pH value in the stomach of the patient has approximately the same value in every measurement. This in particular applies for a time-dependent measurement of the NH3 concentration. In such a measurement the variation of the NH3 concentration in a certain time period is observed. Such a measurement could be disrupted by the continuously occurring production of gastric juices, for example. For this reason, according to a further exemplary embodiment the drink solution is compounded with a pH buffer. A citric acid-phosphate buffer is advantageously used. Such a buffer (also called a Mcllvaine buffer) can be adjusted in a pH range between 2.2 and 8. Its buffer range thus lies in a range of the acid environment of the stomach. A mixture of 0.1 molar citric acid (solution A) and 0.2 molar NaHPO4.4H20 solution (solution B) of buffer composition X ml A+(100−X) ml B is designated as a McIlvaine buffer.
- By adding a pH buffer, constant conditions can be set in the stomach of the patient. This is also advantageous for the acquisition of optical image data since variations in the index of refraction of the drink solution that are caused by variations of the pH value can be avoided.
- As already stated, optimally constant conditions inside the stomach are to be sought for the acquisition of measurement data. This requirement extends not only to the chemical composition of the stomach contents but also to the amount of liquid present in the stomach, for example. In general, a drink solution provided into the stomach remains there only for a relatively short period of time. According to a further exemplary embodiment, the temperature of the drink solution is calibrated essentially to the temperature of the stomach to extend the residence duration. A drink solution that is preheated to approximately body temperature has multiple advantages. On the one hand, temperature-dependent density changes within the drink solution do not occur. Such density changes lead to variations in the index of refraction of the drink solution and thus lead to streak formation in the image data. Moreover, a warm drink solution will drain more slowly from the pylorus into the duodenum than a cold drink solution. The residence duration of the preheated drink solution in the stomach is thus improved.
- In addition to classical endoscopy and capsule endoscopy, the possibility moreover exists to use a magnetically navigable capsule endoscope to detect measurement values in the stomach of a patient. The aforementioned measures that largely suppress a bubble formation within the stomach of a patient are in particular relevant when such a magnetically controlled endoscopy capsule is used.
- A technical problem which occurs in the use of a drink solution that has not been degassed is that bubbles accumulate on the outside of the endoscopy capsule. The bubbles—which have accumulated in a partial region, for example—lead there to local buoyancy forces at the capsule endoscope, whereby its control is made significantly more difficult. In the worst case, the capsule can start to tumble; in this case a targeted measurement value acquisition is impossible.
- The use of a degassed drink solution prevents the situation that bubbles can accumulate at the surface of the capsule endoscope. The capsule endoscope can be navigated without problems. The navigability/mobility of the endoscope capsule inside the stomach can be additionally improved in that a silicone oil is admixed with the drink solution. In addition to the aforementioned effect that the bubble formation is reduced, this has the effect of a lubricant. The friction forces between the capsule endoscope and the drink fluid and between the capsule endoscope and the stomach wall are reduced; the navigability of the capsule is improved.
- In order to enable a friction-less workflow of the measurements in the stomach of the patient, the drink solution can be provided with the admixtures and be degassed insofar as this is necessary. Such a prepared drink solution must merely be correspondingly tempered before it is brought into the stomach of the patient. Such a prepared drink solution allows a high workflow in the measurement value acquisition.
- With the use of the described measures it can be achieved that the physical and chemical properties of the drink solution achieve optimally constant conditions in the stomach of the patient during the measurement value acquisition. The measurement value acquisition is more reliable and reproducible.
- Although modifications and changes may be suggested by those skilled in the art, it is the intention of the inventors to embody within the patent warranted heron all changes and modifications as reasonably and properly come within the scope of their contribution to the art.
Claims (17)
1.-17. (canceled)
18. A method for acquiring measurement data from the stomach of a patient, comprising the steps of:
degassing an aqueous drink solution and thereafter administering the degassed aqueous drink solution to the stomach of a patient; and
acquiring measurement data from the stomach of the patient using an endoscope with said degassed aqueous drink solution present in the stomach of the patient during the acquisition of the measurement data.
19. A method as claimed in claim 18 comprising degassing said aqueous drink solution by vacuum degassing.
20. A method as claimed in claim 18 comprising preparing said aqueous drink solution isotonically.
21. A method as claimed in claim 20 comprising preparing said aqueous drink solution isotonically by adding NaCl thereto.
22. A method as claimed in claim 18 comprising compounding said aqueous drink solution with a silicone oil.
23. A method as claimed in claim 18 comprising acquiring image data as said measurement data using a camera contained in said endoscope.
24. A method as claimed in claim 18 comprising compounding said aqueous drink solution with a pH buffer.
25. A method as claimed in claim 24 comprising employing a citric acid phosphate buffer as said pH buffer.
26. A method as claimed in claim 18 comprising calibrating a temperature of the degassed aqueous drink solution to a temperature of the stomach.
27. A method as claimed in claim 18 comprising acquiring said measurement data with a magnetically controllable capsule endoscope.
28. An aqueous drink solution comprising a basic aqueous drink solution formulated to be administered into the stomach of a patient, said basic aqueous drink solution being degassed so as to be substantially free of dissolved gas therein.
29. A drink solution as claimed in claim 28 wherein said basic aqueous drink solution is isotonic.
30. A drink solution as claimed in claim 29 containing NaCl in isotonic concentration.
31. A drink solution as claimed in claim 28 containing silicone oil.
32. A drink solution as claimed in claim 28 compounded with a pH buffer.
33. A drink solution as claimed in claim 32 comprising a citric acid phosphate buffer as said pH buffer.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/240,340 US10231606B2 (en) | 2008-07-30 | 2016-08-18 | Method for determining measured data from the stomach of a patient |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102008035542.9 | 2008-07-30 | ||
DE102008035542A DE102008035542A1 (en) | 2008-07-30 | 2008-07-30 | Method for determining measurement data from the stomach of a patient |
PCT/EP2009/054424 WO2010012513A2 (en) | 2008-07-30 | 2009-04-15 | Method for determining measured data from the stomach of a patient |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2009/054424 A-371-Of-International WO2010012513A2 (en) | 2008-07-30 | 2009-04-15 | Method for determining measured data from the stomach of a patient |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/073,170 Division US20140058199A1 (en) | 2008-07-30 | 2013-11-06 | Method for determining measured data from the stomach of a patient |
Publications (1)
Publication Number | Publication Date |
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US20110178368A1 true US20110178368A1 (en) | 2011-07-21 |
Family
ID=41461490
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/056,394 Abandoned US20110178368A1 (en) | 2008-07-30 | 2009-04-15 | Method for determining measured data from the stomach of a patient |
US14/073,170 Abandoned US20140058199A1 (en) | 2008-07-30 | 2013-11-06 | Method for determining measured data from the stomach of a patient |
US15/240,340 Active 2029-10-10 US10231606B2 (en) | 2008-07-30 | 2016-08-18 | Method for determining measured data from the stomach of a patient |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/073,170 Abandoned US20140058199A1 (en) | 2008-07-30 | 2013-11-06 | Method for determining measured data from the stomach of a patient |
US15/240,340 Active 2029-10-10 US10231606B2 (en) | 2008-07-30 | 2016-08-18 | Method for determining measured data from the stomach of a patient |
Country Status (4)
Country | Link |
---|---|
US (3) | US20110178368A1 (en) |
CN (2) | CN102112043A (en) |
DE (1) | DE102008035542A1 (en) |
WO (1) | WO2010012513A2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20140308425A1 (en) * | 2011-11-22 | 2014-10-16 | Suntory Holdings Limited | Non-alcohol, beer-taste beverage having improved finish |
US20140322427A1 (en) * | 2011-11-22 | 2014-10-30 | Suntory Holdings Limited | Non-alcohol, beer-taste beverage having high ratio of monosaccharides and disaccharides |
US10993460B2 (en) | 2012-12-28 | 2021-05-04 | Suntory Holdings Limited | Non-alcohol, beer-taste beverage having Shimari in taste |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11389105B2 (en) | 2017-10-31 | 2022-07-19 | Brittany Molkenthin | Systems and methods for measuring a quantity of breast milk consumed by a baby |
CN107997791A (en) * | 2017-12-15 | 2018-05-08 | 赵继国 | A kind of cardiovascular devices |
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2008
- 2008-07-30 DE DE102008035542A patent/DE102008035542A1/en not_active Ceased
-
2009
- 2009-04-15 CN CN200980129732.8A patent/CN102112043A/en active Pending
- 2009-04-15 WO PCT/EP2009/054424 patent/WO2010012513A2/en active Application Filing
- 2009-04-15 US US13/056,394 patent/US20110178368A1/en not_active Abandoned
- 2009-04-15 CN CN201610663830.1A patent/CN106214113A/en active Pending
-
2013
- 2013-11-06 US US14/073,170 patent/US20140058199A1/en not_active Abandoned
-
2016
- 2016-08-18 US US15/240,340 patent/US10231606B2/en active Active
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US20140308425A1 (en) * | 2011-11-22 | 2014-10-16 | Suntory Holdings Limited | Non-alcohol, beer-taste beverage having improved finish |
US20140322427A1 (en) * | 2011-11-22 | 2014-10-30 | Suntory Holdings Limited | Non-alcohol, beer-taste beverage having high ratio of monosaccharides and disaccharides |
US10993460B2 (en) | 2012-12-28 | 2021-05-04 | Suntory Holdings Limited | Non-alcohol, beer-taste beverage having Shimari in taste |
Also Published As
Publication number | Publication date |
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US10231606B2 (en) | 2019-03-19 |
WO2010012513A2 (en) | 2010-02-04 |
US20160353982A1 (en) | 2016-12-08 |
US20140058199A1 (en) | 2014-02-27 |
CN102112043A (en) | 2011-06-29 |
CN106214113A (en) | 2016-12-14 |
DE102008035542A1 (en) | 2010-02-04 |
WO2010012513A3 (en) | 2010-05-20 |
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