US20100227001A1 - Method of delivering nutrients - Google Patents
Method of delivering nutrients Download PDFInfo
- Publication number
- US20100227001A1 US20100227001A1 US12/398,222 US39822209A US2010227001A1 US 20100227001 A1 US20100227001 A1 US 20100227001A1 US 39822209 A US39822209 A US 39822209A US 2010227001 A1 US2010227001 A1 US 2010227001A1
- Authority
- US
- United States
- Prior art keywords
- vitamin
- improved method
- complex
- bariatric patients
- delivering nutrients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 235000015097 nutrients Nutrition 0.000 title claims abstract description 55
- 238000000034 method Methods 0.000 title claims abstract description 44
- 229940088594 vitamin Drugs 0.000 claims abstract description 63
- 239000011782 vitamin Substances 0.000 claims abstract description 63
- 239000007788 liquid Substances 0.000 claims abstract description 33
- 229930003231 vitamin Natural products 0.000 claims abstract description 29
- 235000013343 vitamin Nutrition 0.000 claims abstract description 28
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 23
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 20
- 235000019156 vitamin B Nutrition 0.000 claims abstract description 20
- 239000011720 vitamin B Substances 0.000 claims abstract description 20
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 19
- 239000007787 solid Substances 0.000 claims abstract description 16
- 239000012460 protein solution Substances 0.000 claims abstract description 15
- 150000001875 compounds Chemical class 0.000 claims abstract description 14
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 12
- 229910052742 iron Inorganic materials 0.000 claims abstract description 11
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 10
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 10
- 239000011709 vitamin E Substances 0.000 claims abstract description 10
- 229940046009 vitamin E Drugs 0.000 claims abstract description 10
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000011575 calcium Substances 0.000 claims abstract description 8
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 8
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 7
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 7
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 6
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims abstract description 6
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 6
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 6
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims abstract description 6
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims abstract description 6
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims abstract description 6
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 6
- 229930003316 Vitamin D Natural products 0.000 claims abstract description 6
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 6
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 6
- 239000011651 chromium Substances 0.000 claims abstract description 6
- 229910052804 chromium Inorganic materials 0.000 claims abstract description 6
- 229910052802 copper Inorganic materials 0.000 claims abstract description 6
- 239000010949 copper Substances 0.000 claims abstract description 6
- 239000000835 fiber Substances 0.000 claims abstract description 6
- 239000011572 manganese Substances 0.000 claims abstract description 6
- 229910052748 manganese Inorganic materials 0.000 claims abstract description 6
- 239000011669 selenium Substances 0.000 claims abstract description 6
- 229910052711 selenium Inorganic materials 0.000 claims abstract description 6
- 235000019155 vitamin A Nutrition 0.000 claims abstract description 6
- 239000011719 vitamin A Substances 0.000 claims abstract description 6
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 6
- 239000011718 vitamin C Substances 0.000 claims abstract description 6
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 6
- 239000011710 vitamin D Substances 0.000 claims abstract description 6
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 6
- 229940045997 vitamin a Drugs 0.000 claims abstract description 6
- 229940046008 vitamin d Drugs 0.000 claims abstract description 6
- 239000011701 zinc Substances 0.000 claims abstract description 6
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 6
- 229930003448 Vitamin K Natural products 0.000 claims abstract description 5
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims abstract description 5
- 235000019168 vitamin K Nutrition 0.000 claims abstract description 5
- 239000011712 vitamin K Substances 0.000 claims abstract description 5
- 150000003721 vitamin K derivatives Chemical class 0.000 claims abstract description 5
- 229940046010 vitamin k Drugs 0.000 claims abstract description 5
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 10
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 9
- 229930003270 Vitamin B Natural products 0.000 claims description 7
- 229930003779 Vitamin B12 Natural products 0.000 claims description 7
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 7
- 235000019163 vitamin B12 Nutrition 0.000 claims description 7
- 239000011715 vitamin B12 Substances 0.000 claims description 7
- 229930003761 Vitamin B9 Natural products 0.000 claims description 5
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 5
- 235000019158 vitamin B6 Nutrition 0.000 claims description 5
- 239000011726 vitamin B6 Substances 0.000 claims description 5
- 235000019159 vitamin B9 Nutrition 0.000 claims description 5
- 239000011727 vitamin B9 Substances 0.000 claims description 5
- 229940011671 vitamin b6 Drugs 0.000 claims description 5
- 108010016626 Dipeptides Proteins 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 101710118538 Protease Proteins 0.000 claims description 2
- 235000019658 bitter taste Nutrition 0.000 claims description 2
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 1
- 235000019157 thiamine Nutrition 0.000 claims 1
- 239000011721 thiamine Substances 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 16
- 229940046001 vitamin b complex Drugs 0.000 abstract description 12
- 238000009472 formulation Methods 0.000 abstract description 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 2
- 210000002784 stomach Anatomy 0.000 description 15
- 239000006187 pill Substances 0.000 description 11
- 230000002496 gastric effect Effects 0.000 description 9
- 238000001356 surgical procedure Methods 0.000 description 9
- 238000007681 bariatric surgery Methods 0.000 description 7
- 210000002249 digestive system Anatomy 0.000 description 5
- 239000013589 supplement Substances 0.000 description 5
- 230000001079 digestive effect Effects 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- -1 Fibersol Chemical compound 0.000 description 3
- 206010047700 Vomiting Diseases 0.000 description 3
- 230000003042 antagnostic effect Effects 0.000 description 3
- 230000002183 duodenal effect Effects 0.000 description 3
- 210000000813 small intestine Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- 229920002774 Maltodextrin Polymers 0.000 description 2
- 239000005913 Maltodextrin Substances 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 210000005178 buccal mucosa Anatomy 0.000 description 2
- 230000001010 compromised effect Effects 0.000 description 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 229940029329 intrinsic factor Drugs 0.000 description 2
- 229940035034 maltodextrin Drugs 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000018343 nutrient deficiency Nutrition 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- WVXRAFOPTSTNLL-NKWVEPMBSA-N 2',3'-dideoxyadenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1CC[C@@H](CO)O1 WVXRAFOPTSTNLL-NKWVEPMBSA-N 0.000 description 1
- 208000000412 Avitaminosis Diseases 0.000 description 1
- 241000167854 Bourreria succulenta Species 0.000 description 1
- 229910021555 Chromium Chloride Inorganic materials 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 240000003394 Malpighia glabra Species 0.000 description 1
- 235000014837 Malpighia glabra Nutrition 0.000 description 1
- 102000007474 Multiprotein Complexes Human genes 0.000 description 1
- 108010085220 Multiprotein Complexes Proteins 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- RJFAYQIBOAGBLC-BYPYZUCNSA-N Selenium-L-methionine Chemical compound C[Se]CC[C@H](N)C(O)=O RJFAYQIBOAGBLC-BYPYZUCNSA-N 0.000 description 1
- RJFAYQIBOAGBLC-UHFFFAOYSA-N Selenomethionine Natural products C[Se]CCC(N)C(O)=O RJFAYQIBOAGBLC-UHFFFAOYSA-N 0.000 description 1
- 208000007642 Vitamin B Deficiency Diseases 0.000 description 1
- 206010047627 Vitamin deficiencies Diseases 0.000 description 1
- 208000010045 Wernicke encephalopathy Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 235000014104 aloe vera supplement Nutrition 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000019693 cherries Nutrition 0.000 description 1
- QSWDMMVNRMROPK-UHFFFAOYSA-K chromium(3+) trichloride Chemical compound [Cl-].[Cl-].[Cl-].[Cr+3] QSWDMMVNRMROPK-UHFFFAOYSA-K 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 229910000365 copper sulfate Inorganic materials 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 235000000639 cyanocobalamin Nutrition 0.000 description 1
- 239000011666 cyanocobalamin Substances 0.000 description 1
- 229960002104 cyanocobalamin Drugs 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 235000002532 grape seed extract Nutrition 0.000 description 1
- 229940087603 grape seed extract Drugs 0.000 description 1
- 235000020688 green tea extract Nutrition 0.000 description 1
- 229940094952 green tea extract Drugs 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 235000012680 lutein Nutrition 0.000 description 1
- 229960005375 lutein Drugs 0.000 description 1
- 239000001656 lutein Substances 0.000 description 1
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 description 1
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 229940099596 manganese sulfate Drugs 0.000 description 1
- 239000011702 manganese sulphate Substances 0.000 description 1
- 235000007079 manganese sulphate Nutrition 0.000 description 1
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 235000020802 micronutrient deficiency Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 235000020786 mineral supplement Nutrition 0.000 description 1
- 229940029985 mineral supplement Drugs 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 235000015816 nutrient absorption Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960002718 selenomethionine Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 1
- 235000019195 vitamin supplement Nutrition 0.000 description 1
- 239000001717 vitis vinifera seed extract Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/32—Manganese; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the method of the invention ensures sufficient nutrient delivery to the bariatric patient while maximizing absorption and speed of delivery.
- the method substantially limits the ingredients to nutrients that are needed by the bariatric patient and avoids unnecessary ingredients that can bind together with vital nutrients or have an antagonistic effect on such nutrients.
- the form of nutrients allows a bariatric patient to experience greater tolerance to the delivery of the nutrients and the patient is able to conveniently administer delivery of the nutrients.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Physiology (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
A method of delivering nutrients for bariatric patients comprising the sublingual administration of a B-complex vitamin composition and ingesting a liquid, water-soluble multi-vitamin complex orally at approximately the same time. The liquid multi-vitamin is comprised of a plurality of compounds from the group of Vitamin A, Vitamin C, Vitamin D and Vitamin E. After administering the Vitamin B complex and the liquid multi-vitamin, a solid vitamin formulation comprising at least two compounds from the group of iron, zinc, selenium, copper, chromium, Vitamin K, and manganese is ingested orally. A protein solution comprising proteins broken down into small peptide chains, calcium, and fiber may also be delivered orally to the bariatric patient in a liquid form. The method may be repeated once or twice daily. The method of the invention maximizes delivery and absorption of nutrients to the bariatric patient and the tolerance and speed of delivery.
Description
- This invention relates generally to methods of delivering nutrients to individuals, and more particularly to individuals that have undergone bariatric surgery.
- Bariatric surgery refers to various surgical procedures used to treat obesity that involve the modification of the patient's gastrointestinal tract in order reduce the quantity of nutrients taken in and absorbed. Approximately 170,000 individuals undergo bariatric surgery in the U.S. every year. Primarily restrictive procedures are performed to reduce the patient's stomach size. For instance, laparoscopic adjustable gastric banding is a primarily restrictive bariatric procedure in which a band or belt is placed around the upper part of the stomach. The effective size of the stomach is decreased and leads to a decrease in hunger and the amount of food capable of being comfortably ingested.
- Other types of bariatric surgery procedures create a malabsorptive state. For instance, a “biliopancreatic diversion with duodenal switch” switches the duodenum with the ileum as the immediate connection of the stomach to the small intestine. This creates a shorter distance for nutrient absorption time before the food passes to the large intestines.
- Gastric bypass surgery such as Roux-en-Y gastric bypass surgery is the most commonly performed bariatric surgery. Roux-en-Y gastric bypass surgery involves both the reduction of the stomach size and the creation of a malabsorptive state. In Roux-en-Y gastric bypass surgery, the stomach area is reduced by creating a small stomach pouch with a stapler device to reduce the stomach by approximately 95%. The size of the new stomach pouch is only able to accommodate 10-15 ml of volume. The malabsorptive state is created in a Roux-en-Y gastric bypass surgery by connecting the small stomach pouch with the distal small intestine. The upper part of the small intestine is then reattached in a Y-shaped configuration.
- While bariatric surgery is effective at allowing an individual to lose weight, malnutrition and micronutrient deficiency are known complications of such surgery. The modifications to the stomach in Roux-en-Y gastric bypass surgery and the biliopancreatic diversion with duodenal switch limit the patients' ability to absorb vitamins and nutrients. In addition, the reduction of food consumed by the bariatric patient further reduces the amount of available nutrients. Bariatric patients thus have an increased risk of nutrient deficiencies, such as B-12 deficiency, which can cause anemia and damage to the nervous system.
- Accordingly, it is recommended that bariatric patients take vitamin and mineral supplements to ensure that they receive sufficient nutrients. However, as a result of their surgeries, bariatric patients have increased difficulty in digesting and absorbing nutritional supplements in common forms. For instance, vitamins in pill form take at least four hours to dissolve, and the majority of provided supplements have already passed into the lower intestine of the individual by the time the pill dissolves, thereby limiting the benefits of the supplements. Furthermore, traditional supplements put undue stress on the patient's compromised digestive system. Vitamins in pill forms contain binders, fillers, artificial colors, sweeteners, wax coating and preservatives which may tax the digestive system. The vitamins are large and dense and are difficult to swallow and often many pills are needed to satisfy the recommended intake. This causes inconvenience and difficulty in ingesting the required supplements. Pills have also been known to get stuck in the banded portion of a laparoscopic adjustable gastric banding patient. Vomiting due to reactions to common pill supplements can be dangerous and increases the adverse effects of vitamin deficiencies. Vomiting was found to be a risk factor for the development of Wernicke encephalopathy in bariatric patients.
- Vitamin B-12 is particularly difficult to metabolize in patients having a Roux-en-Y gastric bypass or a biliopancreatic diversion with duodenal switch procedures because intrinsic factor, a protein produced by glands in the stomach lining, is necessary for full absorption of the Vitamin B complex. Since the stomach is substantially eliminated in these patients, Vitamin B-12 is not metabolized properly. A vitamin B deficiency can lead to further nutrient deficiencies as well; complete absorption of the vitamin B complex is essential for absorption of other nutrients.
- Accordingly, it is an object of the present invention to provide a method for nutrient delivery that results in increased absorption of nutrients by bariatric patients.
- Yet another object of the present invention is to provide a method for nutrient delivery that is quickly absorbed by bariatric patients.
- It is another object of the present invention to provide a method for nutrient delivery that is more easily tolerated by bariatric patients.
- Still a further object of the present invention to provide a method for nutrient delivery that is easily administered by bariatric patients.
- It is also an object of the present invention to provide a method for nutrient delivery that is efficient and cost effective to implement.
- The foregoing objects are met by the present invention directed to an improved method of delivering nutrients for bariatric patients. The invention is a multi-step administration regimen, each step being tailored to the specific nutrients to be delivered.
- A first step of the method involves the sublingual administration of a B-complex vitamin composition. Sublingual administration provides for a quick and high rate of absorption and avoids the need for processing by the patient's digestive system.
- The second step, which may be performed at approximately the same time that the user delivers the Vitamin B composition to the sublingual area, is to ingest a liquid multi-vitamin complex orally. The liquid multi-vitamin is water-soluble and is comprised preferably of two or more of Vitamin A, Vitamin C, Vitamin D and Vitamin E.
- After administering the Vitamin B-complex and the liquid multi-vitamin, the user orally ingests a solid vitamin formulation comprising at least two nutrients from the group of Iron, Zinc, Selenium, Copper, Chromium, Vitamin K, and Manganese. The solid multi-vitamin does not contain Vitamin B, which bariatric patients are unable to digest in the stomach. The elimination of Vitamin B differs from other multi-vitamin tabs in the prior art and allows the user to ingest a plurality of vitamins without experiencing digestive problems arising from indigestible B Vitamin compounds.
- The combined administration of the sublingual B-complex vitamin composition, the liquid multi-vitamin complex and the solid multi-vitamin as specified in the present invention is so effective that it may be performed only once a day. However, the administration may performed twice daily, if necessary.
- In a further embodiment, a protein solution comprising proteins broken down into dipeptide or tripeptide chains is also orally delivered in a liquid form. Calcium and fiber such as Fibersol, a digestive resistant, highly soluble maltodextrin, may also be added to the protein solution.
- The method of the invention ensures sufficient nutrient delivery to the bariatric patient while maximizing absorption and speed of delivery. The method substantially limits the ingredients to nutrients that are needed by the bariatric patient and avoids unnecessary ingredients that can bind together with vital nutrients or have an antagonistic effect on such nutrients. The form of nutrients allows a bariatric patient to experience greater tolerance to the delivery of the nutrients and the patient is able to conveniently administer delivery of the nutrients.
- The present invention is directed to an improved method for nutrient delivery, and in particular, for delivering nutrients to bariatric patients. The first step of the method involves the sublingual administration of a B-complex vitamin composition. Sublingual delivery refers to administering substances by bringing them into contact with the highly vascularized mucous membrane, the buccal mucosa, under the tongue. The chemicals diffuse through the buccal mucosa and enter the venous circulation.
- The advantages of sublingual delivery as compared with oral administration are that the substances are absorbed much more quickly because they directly enter the bloodstream. Sublingual administration also eliminates processing by the digestive system and avoids degradation from the gastrointestinal tract and liver. For instance, the sublingual administration of the Vitamin B Complex allows a bariatric patient to fully absorb the Vitamin B Complex without requiring the stomach, which lacks intrinsic factor, to process the compound for absorption. There is also a substantially greater degree of absorption from sublingual administration as opposed to oral administration.
- The Vitamin B Complex preferably comprises Vitamin B12. The Vitamin B12 form may be cyanocobalamin, a commonly used B12 vitamin form. Vitamin B12 is tolerated at high doses by bariatric patients. The Vitamin B Complex may also comprise Vitamin B6 and Vitamin B9 (folic acid). Both Vitamin B6 and Vitamin B9 must be taken in moderate levels since these components may be harmful at high levels. The preferable concentrations of the Vitamin B Complex are a range of 5-10 mg of Vitamin B6, 1000-2000 mcg of Vitamin B12 and 400-1000 mcg of Vitamin B9.
- The sublingual delivery may be accomplished by using a liquid form of the Vitamin B Complex and delivering it to the sublingual area by an appropriately calibrated spray bottle dispenser. Alternatively, a dropper or other means well known in the art may be implemented.
- At approximately the same time that the user delivers the Vitamin B composition to the sublingual area, the user orally ingests a liquid multi-vitamin complex. The liquid multi-vitamin is comprised preferably of two or more compounds from the group of Vitamin A, Vitamin C, Vitamin D and Vitamin E. In order to enhance absorption, it is preferable that the vitamins are all in a water soluble form. While Vitamin E is a fat soluble vitamin, Vitamin E may be rendered water soluble by adding a solubizer such as a polysorbate to the compound during the manufacturing process. The water-soluble Vitamin E exhibits increased absorption through the intestinal wall as compared to conventional Vitamin E. The liquid multi-vitamin may also include acerola cherry extract, aloe vera extract, citrus bioflavinoids, grape seed extract, green tea extract, lutein, lycopene, and a trace mineral complex.
- Liquid multivitamins ingested orally are more rapidly absorbed by the body and have a significantly higher absorption rate as compared with ingesting a multivitamin in pill or tablet form. Research suggests that only 10-20% of vitamins and minerals in a pill are absorbed by the body compared to 98% for liquid vitamins. The liquid vitamins bypass the digestive process and are absorbed directly into the blood stream. Tests show that 85-90% of the nutrients in a liquid vitamin are absorbed in 25 to 30 seconds. The liquid form is also easier to ingest and is less likely to cause nausea or vomiting than pills. Liquid multi-vitamins also do not contain fillers or other additives which may inhibit absorption or increase the difficulty in metabolizing the nutrients.
- A preferable concentration of the liquid multi-vitamins is Vitamin A in the range of 10,000-20,000 IU, Vitamin C in the range of 150-500 IU, Vitamin D in the range of 600-1200 IU, and Vitamin E in the range of 100-400 IU. It is preferred that the liquid multi-vitamin does not contain any Vitamin B compounds, since the Vitamin B Complex is being administered sublingually at the same time as the liquid multi-vitamin is ingested.
- After administering the Vitamin B Complex and the liquid multi-vitamin, the user ingests orally a solid vitamin formulation comprising at least two compounds from the group of Iron, Zinc, Selenium, Copper, Chromium, Vitamin K, and Manganese. The preferable concentration of the solid vitamin formulation is iron in the form of Ferronyl® iron in the range of 20-50 mg, Zinc in the form of Zinc Oxide in the range of 20-40 mg, Selenium in the form of Selenomethionine in the range of 70-160 mcg, Copper in the form of Copper Sulfate in the range of 60-150 mcg, Vitamin K in the range of 60 mcg-120 mcg, Chromium in the form of Chromium Chloride in the range of 60-80 mcg, and Manganese in the form of Manganese Sulfate in the range of 2-8 mg. Sufficient delivery and absorption of iron is particular important to bariatric patients because they experience increased difficulty tolerating foods rich in iron such as meat and their compromised digestive system has problems absorbing iron. The multi-vitamin tab preferably has no Vitamin B compounds since bariatric patients have problems digesting such compounds through oral administration.
- In a preferred embodiment, the solid multi-vitamin is in the form of a rapid disintegrating tab. These tabs dissolve within seconds of ingestion and offers maximal absorption. The tabs are absorbed in approximately two minutes which is much quicker than multi-vitamins in a typical solid pill form and the tabs are much more easily tolerated than solid pills.
- The method of administering the sublingual B-complex vitamin composition, the liquid multi-vitamin complex and the solid multi-vitamin may be performed once or twice daily as needed by the patient.
- In another embodiment, a protein solution comprising proteins broken down into dipeptide or tripeptide chains are also orally delivered to the bariatric patient in a liquid form. The small peptide chains are easily digested by the bariatric patient and overcomes the difficulties many patients have metabolizing large protein complexes. It is preferred that the protein solution is made with endoprotease which cuts the protein chains at the proline amino acid to substantially remove bitterness in the protein solution. Calcium and fiber such as Fibersol, a digestive resistant, highly soluble maltodextrin may also be added to the protein solution. In a preferred embodiment the concentration of protein is 15 g, calcium is 60 mg and fiber is 2 g. If the protein solution contains calcium, it is preferable that the protein solution is taken at a different time than the solid multi-vitamin formulation to avoid a mutually antagonistic effect between iron and calcium.
- The method of the invention maximizes nutrient delivery to the bariatric patient as well as maximizing absorption and speed of delivery. The form of nutrients allows a bariatric patient to have greater tolerance and the patient is able to conveniently administer delivery of the nutrients. The method substantially limits the ingredients to nutrients that are needed by the bariatric patient and avoids unnecessary ingredients that can bind together with vital nutrients or have an antagonistic effect on an important nutrient.
- It should be understood, of course, that the specific form of the invention herein illustrated and described is intended to be representative only, as certain changes may be made therein without departing from the clear teachings of the disclosure. Accordingly, reference should be made to the following appended claims in determining the full scope of the invention.
Claims (20)
1. An improved method for delivering nutrients to bariatric patients comprising:
administering a liquid B-complex vitamin composition sublingually;
ingesting a liquid multi-vitamin complex orally; and
ingesting orally a multi-vitamin in a solid form comprising two or more compounds from the group of iron, zinc, selenium, copper, chromium, Vitamin K, and manganese.
2. The improved method for delivering nutrients to bariatric patients in claim 1 wherein said sublingual B-complex vitamin composition comprises Vitamin B12.
3. The improved method for delivering nutrients to bariatric patients in claim 2 wherein said sublingual B-complex vitamin comprises 12 mg of Vitamin B12.
4. The improved method for delivering nutrients to bariatric patients in claim 2 wherein said sublingual B-complex vitamin composition further comprises Vitamin B6 and Vitamin B9.
5. The improved method for delivering nutrients to bariatric patients in claim 4 wherein said sublingual B-complex vitamin composition comprises Vitamin B6 in the range of 5-10 mg, Vitamin B12 in the range of 1000-2000 mcg, and Vitamin B9 in the range of 400-1000 mcg.
6. The improved method for delivering nutrients to bariatric patients in claim 4 wherein said sublingual B-complex vitamin composition further comprises thiamin in the range of 1 mg to 2 mg.
7. The improved method for delivering nutrients to bariatric patients in claim 1 wherein said liquid multi-vitamin complex comprises a plurality of compounds from the group of Vitamin A, Vitamin C, Vitamin D and Vitamin E.
8. The improved method for delivering nutrients to bariatric patients in claim 1 wherein said liquid multi-vitamin complex is in a water soluble form.
9. The improved method for delivering nutrients to bariatric patients in claim 7 wherein said liquid multi-vitamin complex comprises a plurality of compounds from said group in the following concentrations: Vitamin A in the range of 10,000-20,000 IU, Vitamin C in the range of 150-500 IU, Vitamin D in the range of 600-1200 IU, and Vitamin E in the range of 100-400 IU.
10. The improved method for delivering nutrients to bariatric patients in claim 1 wherein said solid multi-vitamin comprises a plurality of compounds from said group in the following concentrations: zinc in the range of 20-40 mg, selenium in the range of 70-160 mcg, copper in the range of 60-150 mcg, chromium in the range of 60-80 mcg, manganese in the range of 2-8 mg, and iron in the range of 20-50 mg.
11. The improved method for delivering nutrients to bariatric patients in claim 1 wherein said solid multi-vitamin does not contain Vitamin B.
12. The improved method for delivering nutrients to bariatric patients in claim 1 wherein said steps are repeated once or twice daily.
13. The improved method for delivering nutrients to bariatric patients in claim 1 further comprising the step of ingesting orally a liquid protein solution comprising dipeptides and tripeptides.
14. The improved method for delivering nutrients to bariatric patients in claim 13 wherein said liquid protein solution is manufactured with endoprotease thereby minimizing bitterness in said solution.
15. The improved method for delivering nutrients to bariatric patients in claim 13 wherein said protein solution further comprises calcium.
16. The improved method for delivering nutrients to bariatric patients in claim 15 wherein said protein solution further comprises fiber.
17. The improved method for delivering nutrients to bariatric patients in claim 16 wherein said protein solution comprises 10-20 gm of protein, 45-75 mg of calcium, and 1-3 grams of fiber.
18. The improved method for delivering nutrients to bariatric patients in claim 13 wherein said protein solution is ingested at a different time than said solid multi-vitamin composition.
19. The improved method for delivering nutrients to bariatric patients in claim 1 wherein said solid multi-vitamin is in the form of a rapidly dissolving tab.
20. An improved method for delivering nutrients to bariatric patients comprising:
Administering a liquid B-complex vitamin composition sublingually; and
Ingesting a multi-vitamin complex orally.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/398,222 US20100227001A1 (en) | 2009-03-05 | 2009-03-05 | Method of delivering nutrients |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/398,222 US20100227001A1 (en) | 2009-03-05 | 2009-03-05 | Method of delivering nutrients |
Publications (1)
Publication Number | Publication Date |
---|---|
US20100227001A1 true US20100227001A1 (en) | 2010-09-09 |
Family
ID=42678482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/398,222 Abandoned US20100227001A1 (en) | 2009-03-05 | 2009-03-05 | Method of delivering nutrients |
Country Status (1)
Country | Link |
---|---|
US (1) | US20100227001A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL2013645C2 (en) * | 2014-10-17 | 2015-06-11 | Fit For Me B V | Pharmaceutical composition for use in the treatment or prevention of vitamin and mineral deficiencies in patients which have been subjected to gastric bypass-surgery. |
ITUB20160068A1 (en) * | 2016-01-28 | 2017-07-28 | Paolo Ferrazza | Useful composition in the prevention or treatment of malabsorption states secondary to bariatric surgery in obese subjects. |
WO2018081048A1 (en) * | 2016-10-24 | 2018-05-03 | Callion Pharma | Antioxidant-enriched multivitamin composition and methods of use |
WO2019130167A1 (en) * | 2017-12-28 | 2019-07-04 | L.N. Age S.R.L. | Composition for use in the treatment of malabsorption secondary to bariatric surgery |
US11617714B2 (en) | 2016-12-16 | 2023-04-04 | Jeffrey R Olynyk | Sublingual therapeutic solutions and methods |
Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3626065A (en) * | 1967-05-25 | 1971-12-07 | Shionogi & Co | Stable aqueous multivitamin preparations |
US4358720A (en) * | 1980-02-25 | 1982-11-09 | Sony Corporation | DC Motor driving circuit |
US4432975A (en) * | 1981-04-13 | 1984-02-21 | Icn Pharmaceuticals, Inc. | Process for introducing vitamin B-12 into the bloodstream |
US5906833A (en) * | 1995-05-22 | 1999-05-25 | Klatz; Ronald M. | Chronological food bar |
US5932624A (en) * | 1995-10-17 | 1999-08-03 | Herbert; Victor D. | Vitamin supplement composition |
US5945123A (en) * | 1998-04-02 | 1999-08-31 | K-V Pharmaceutical Company | Maximizing effectiveness of substances used to improve health and well being |
US5948443A (en) * | 1996-02-23 | 1999-09-07 | Medical Doctor's Research Institute, Inc. | Acetylsalicylic acid and micronutrient supplementation for nutritional losses and coronary heart disease |
US5977175A (en) * | 1995-05-17 | 1999-11-02 | Cedars-Sinai Medical Center | Methods and compositions for improving digestion and absorption in the small intestine |
US5976568A (en) * | 1997-02-21 | 1999-11-02 | Medical Doctors' Research Institute, Inc. | Modular system of dietary supplement compositions for optimizing health benefits and methods |
US20020094346A1 (en) * | 1995-05-17 | 2002-07-18 | M. D. Henry C. Lin | Method and compositions for improving digestion and absorption in the small intestine |
US20050112211A1 (en) * | 2003-08-21 | 2005-05-26 | Eric Gervais | Micronutrient supplement |
US20050226907A1 (en) * | 2004-04-08 | 2005-10-13 | Moneymaker Ricky D | Pharmanutrient composition(s) and system(s) for individualized, responsive dosing regimens |
US20060269619A1 (en) * | 2004-04-08 | 2006-11-30 | Micro Nutrient, Llc | Nutrient system for individualized responsive dosing regimens |
US20060280761A1 (en) * | 2002-03-11 | 2006-12-14 | Health Plus International, Inc. | Nanofluidized B-12 composition and process for treating pernicious anemia |
US7205007B2 (en) * | 2003-04-08 | 2007-04-17 | Fairfield Clinical Trials, Llc | Peri-operative and peri-procedure nutritional supplementation |
-
2009
- 2009-03-05 US US12/398,222 patent/US20100227001A1/en not_active Abandoned
Patent Citations (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3626065A (en) * | 1967-05-25 | 1971-12-07 | Shionogi & Co | Stable aqueous multivitamin preparations |
US4358720A (en) * | 1980-02-25 | 1982-11-09 | Sony Corporation | DC Motor driving circuit |
US4432975A (en) * | 1981-04-13 | 1984-02-21 | Icn Pharmaceuticals, Inc. | Process for introducing vitamin B-12 into the bloodstream |
US4500515A (en) * | 1981-04-13 | 1985-02-19 | Libby Alfred F | Method for treating alcohol and drug addicts |
US5977175A (en) * | 1995-05-17 | 1999-11-02 | Cedars-Sinai Medical Center | Methods and compositions for improving digestion and absorption in the small intestine |
US20020094346A1 (en) * | 1995-05-17 | 2002-07-18 | M. D. Henry C. Lin | Method and compositions for improving digestion and absorption in the small intestine |
US5906833A (en) * | 1995-05-22 | 1999-05-25 | Klatz; Ronald M. | Chronological food bar |
US5932624A (en) * | 1995-10-17 | 1999-08-03 | Herbert; Victor D. | Vitamin supplement composition |
US5948443A (en) * | 1996-02-23 | 1999-09-07 | Medical Doctor's Research Institute, Inc. | Acetylsalicylic acid and micronutrient supplementation for nutritional losses and coronary heart disease |
US5976568A (en) * | 1997-02-21 | 1999-11-02 | Medical Doctors' Research Institute, Inc. | Modular system of dietary supplement compositions for optimizing health benefits and methods |
US5945123A (en) * | 1998-04-02 | 1999-08-31 | K-V Pharmaceutical Company | Maximizing effectiveness of substances used to improve health and well being |
US20060280761A1 (en) * | 2002-03-11 | 2006-12-14 | Health Plus International, Inc. | Nanofluidized B-12 composition and process for treating pernicious anemia |
US7205007B2 (en) * | 2003-04-08 | 2007-04-17 | Fairfield Clinical Trials, Llc | Peri-operative and peri-procedure nutritional supplementation |
US20050112211A1 (en) * | 2003-08-21 | 2005-05-26 | Eric Gervais | Micronutrient supplement |
US20050226907A1 (en) * | 2004-04-08 | 2005-10-13 | Moneymaker Ricky D | Pharmanutrient composition(s) and system(s) for individualized, responsive dosing regimens |
US20060269619A1 (en) * | 2004-04-08 | 2006-11-30 | Micro Nutrient, Llc | Nutrient system for individualized responsive dosing regimens |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL2013645C2 (en) * | 2014-10-17 | 2015-06-11 | Fit For Me B V | Pharmaceutical composition for use in the treatment or prevention of vitamin and mineral deficiencies in patients which have been subjected to gastric bypass-surgery. |
EP3009133A1 (en) * | 2014-10-17 | 2016-04-20 | Fit For Me B.V. | Pharmaceutical composition for use in the treatment or prevention of vitamin and mineral deficiencies in patient which have been subjected to gastric bypass-surgery |
WO2016060559A1 (en) * | 2014-10-17 | 2016-04-21 | Fit For Me B.V. | Pharmaceutical composition for use in the treatment or prevention of vitamin and mineral deficiencies in patients which have been subjected to gastric bypass-surgery |
ITUB20160068A1 (en) * | 2016-01-28 | 2017-07-28 | Paolo Ferrazza | Useful composition in the prevention or treatment of malabsorption states secondary to bariatric surgery in obese subjects. |
WO2018081048A1 (en) * | 2016-10-24 | 2018-05-03 | Callion Pharma | Antioxidant-enriched multivitamin composition and methods of use |
US11229230B2 (en) | 2016-10-24 | 2022-01-25 | Callion Pharma, Llc | Antioxidant-enriched multivitamin composition and methods of use |
US11617714B2 (en) | 2016-12-16 | 2023-04-04 | Jeffrey R Olynyk | Sublingual therapeutic solutions and methods |
WO2019130167A1 (en) * | 2017-12-28 | 2019-07-04 | L.N. Age S.R.L. | Composition for use in the treatment of malabsorption secondary to bariatric surgery |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Borghi et al. | Nutraceuticals with a clinically detectable blood pressure‐lowering effect: a review of available randomized clinical trials and their meta‐analyses | |
AU2003266400C1 (en) | Leucine-enriched nutritional compositions | |
Ianiro et al. | Levothyroxine absorption in health and disease, and new therapeutic perspectives. | |
US7238373B2 (en) | Nutritional supplement | |
US9220752B2 (en) | Dietary product intended to reduce visceral fat during the pre-operative phase prior to bariatric surgery | |
US20100227001A1 (en) | Method of delivering nutrients | |
US20100190739A1 (en) | Rapidly Dissolving Vitamin Formulation and Methods of Using the Same | |
US7993668B2 (en) | Nutrient composition and composition for prevention/mitigation of digestive tract depression | |
KR20110128329A (en) | Phosphate adsorbent | |
WO2007108712A1 (en) | Kit and method for treating or preventing anemia caused by iron deficiency | |
Rhode et al. | Vitamin and mineral supplementation after gastric bypass | |
CA2380367A1 (en) | Compositions for providing zinc through oral administration | |
Gunturu et al. | Drug–nutrient interactions | |
Vidon et al. | Does lansoprazole influence postprandial digestive function? | |
US20170079311A1 (en) | Method for increasing absorption of plant derived proteins | |
WO2015167002A1 (en) | Composition for improving gastrointestinal disorders | |
JP6841223B2 (en) | Exercise-induced gastrointestinal disorder improver | |
US20040247709A1 (en) | Composition and method for treating upper abdominal pain and cramping | |
Elgar | Nutritional medicine reviews: Zinc: A review of clinical use and efficacy | |
Elgar | Zinc: A Review of Clinical Use and Efficacy | |
CN116157114A (en) | Effervescent formulations containing apoaequorin | |
US9629887B1 (en) | Control of acid reflux with botanicals | |
Stehle | Nutrition support in critical illness: amino acids | |
WO2001052828A2 (en) | Glutamine prevention of delayed-onset irinotecan-induced diarrhea | |
CN108991514A (en) | A kind of vegetarian diet nutrition oral administration and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |