US20090093482A1 - Therapeutic compositions and methods - Google Patents

Therapeutic compositions and methods Download PDF

Info

Publication number
US20090093482A1
US20090093482A1 US12/147,220 US14722008A US2009093482A1 US 20090093482 A1 US20090093482 A1 US 20090093482A1 US 14722008 A US14722008 A US 14722008A US 2009093482 A1 US2009093482 A1 US 2009093482A1
Authority
US
United States
Prior art keywords
pharmaceutically acceptable
acceptable salt
hydroxy
oxo
methylbutan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/147,220
Other languages
English (en)
Inventor
Brian P. Kearney
Anita A. Mathias
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Priority to US12/147,220 priority Critical patent/US20090093482A1/en
Assigned to GILEAD SCIENCES, INC. reassignment GILEAD SCIENCES, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MATHIAS, ANITA A., KEARNEY, BRIAN P.
Publication of US20090093482A1 publication Critical patent/US20090093482A1/en
Priority to US14/281,790 priority patent/US20140343062A1/en
Priority to US15/298,070 priority patent/US20170136000A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
US12/147,220 2007-06-29 2008-06-26 Therapeutic compositions and methods Abandoned US20090093482A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/147,220 US20090093482A1 (en) 2007-06-29 2008-06-26 Therapeutic compositions and methods
US14/281,790 US20140343062A1 (en) 2007-06-29 2014-05-19 Method of treating a viral infection using elvitegravir combinations
US15/298,070 US20170136000A1 (en) 2007-06-29 2016-10-19 Method of treating a viral infection using elvitegravir combinations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94732507P 2007-06-29 2007-06-29
US12/147,220 US20090093482A1 (en) 2007-06-29 2008-06-26 Therapeutic compositions and methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/281,790 Continuation US20140343062A1 (en) 2007-06-29 2014-05-19 Method of treating a viral infection using elvitegravir combinations

Publications (1)

Publication Number Publication Date
US20090093482A1 true US20090093482A1 (en) 2009-04-09

Family

ID=39817166

Family Applications (4)

Application Number Title Priority Date Filing Date
US12/666,995 Abandoned US20110009411A1 (en) 2007-06-29 2008-06-26 Therapeutic compositions and the use thereof
US12/147,220 Abandoned US20090093482A1 (en) 2007-06-29 2008-06-26 Therapeutic compositions and methods
US14/281,790 Abandoned US20140343062A1 (en) 2007-06-29 2014-05-19 Method of treating a viral infection using elvitegravir combinations
US15/298,070 Abandoned US20170136000A1 (en) 2007-06-29 2016-10-19 Method of treating a viral infection using elvitegravir combinations

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US12/666,995 Abandoned US20110009411A1 (en) 2007-06-29 2008-06-26 Therapeutic compositions and the use thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
US14/281,790 Abandoned US20140343062A1 (en) 2007-06-29 2014-05-19 Method of treating a viral infection using elvitegravir combinations
US15/298,070 Abandoned US20170136000A1 (en) 2007-06-29 2016-10-19 Method of treating a viral infection using elvitegravir combinations

Country Status (21)

Country Link
US (4) US20110009411A1 (es)
EP (1) EP2167089A1 (es)
JP (3) JP5547067B2 (es)
KR (1) KR20100028656A (es)
CN (2) CN101743004A (es)
AP (1) AP2490A (es)
AR (1) AR067184A1 (es)
AU (1) AU2008270634B2 (es)
BR (1) BRPI0813955A2 (es)
CA (1) CA2691736A1 (es)
CO (1) CO6251236A2 (es)
EA (1) EA200971096A1 (es)
EC (1) ECSP109889A (es)
IL (1) IL202745A0 (es)
MX (1) MX2009013828A (es)
NZ (1) NZ582089A (es)
SG (1) SG182228A1 (es)
TW (1) TW200916103A (es)
UA (1) UA103881C2 (es)
WO (1) WO2009006203A1 (es)
ZA (1) ZA201000468B (es)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070219243A1 (en) * 2005-12-30 2007-09-20 Kearney Brian P Method for improving the pharmacokinetics of HIV integrase inhibitors
US20090093467A1 (en) * 2007-06-29 2009-04-09 Gilead Sciences, Inc. Therapeutic compositions and methods
US20090099366A1 (en) * 2007-09-11 2009-04-16 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
US20100189687A1 (en) * 2007-02-23 2010-07-29 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
US7825252B2 (en) 2006-09-12 2010-11-02 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
WO2013082476A1 (en) 2011-11-30 2013-06-06 Emory University Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections
US8877931B2 (en) 2012-08-03 2014-11-04 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
US9139541B2 (en) 2006-07-07 2015-09-22 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201591353A1 (ru) 2008-05-02 2016-01-29 Джилид Сайэнс, Инк. Применение частиц твердого носителя для улучшения технологических характеристик фармацевтического агента
WO2011127244A2 (en) * 2010-04-09 2011-10-13 Bristol-Myers Squibb Company ATAZANAVIR SULFATE FORMULATIONS WITH IMPROVED pH EFFECT
US20130274254A1 (en) * 2010-12-21 2013-10-17 Gilead Sciences, Inc. Inhibitors of cytochrome p450 (cyp3a4)
WO2013130766A1 (en) * 2012-03-01 2013-09-06 Gilead Sciences, Inc. Spray dried formulations
CA3012242C (en) 2012-12-21 2021-11-02 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
NO2865735T3 (es) 2013-07-12 2018-07-21
JP6411491B2 (ja) 2013-07-12 2018-10-24 ギリアード サイエンシス インコーポレーテッド 多環式カルバモイルピリドン化合物およびｈｉｖ感染症を処置するためのその使用
NO2717902T3 (es) 2014-06-20 2018-06-23
TWI744723B (zh) 2014-06-20 2021-11-01 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
TWI738321B (zh) 2014-12-23 2021-09-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
SG11201705069YA (en) 2014-12-26 2017-07-28 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto
AU2016244035B2 (en) 2015-04-02 2018-11-01 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
EP3706762A4 (en) 2017-12-07 2021-09-01 Emory University N4-HYDROXYCYTIDINE AND DERIVATIVES AND ANTIVIRAL USES IN RELATION TO IT

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196438A (en) * 1989-12-11 1993-03-23 Hoffmann-La Roche Inc. Amino acid derivatives
US5413999A (en) * 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US5541206A (en) * 1989-05-23 1996-07-30 Abbott Laboratories Retroviral protease inhibiting compounds
US5849911A (en) * 1996-04-22 1998-12-15 Novartis Finance Corporation Antivirally active heterocyclic azahexane derivatives
US5914332A (en) * 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
US6087383A (en) * 1998-01-20 2000-07-11 Bristol-Myers Squibb Company Bisulfate salt of HIV protease inhibitor
US20050239819A1 (en) * 2002-11-20 2005-10-27 Motohide Satoh 4-Oxoquinoline compounds and utilization thereof as hiv integrase inhibitors
US20050288326A1 (en) * 2004-05-21 2005-12-29 Yuji Matsuzaki Combination therapy
US20070219243A1 (en) * 2005-12-30 2007-09-20 Kearney Brian P Method for improving the pharmacokinetics of HIV integrase inhibitors
US20080125594A1 (en) * 2006-09-12 2008-05-29 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
US20090093467A1 (en) * 2007-06-29 2009-04-09 Gilead Sciences, Inc. Therapeutic compositions and methods
US20090099366A1 (en) * 2007-09-11 2009-04-16 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
US20090233964A1 (en) * 2005-12-30 2009-09-17 Gilead Sciences, Inc. Methods for improving the pharmacokinetics of hiv integrase inhibitors
US20090291952A1 (en) * 2006-07-07 2009-11-26 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
US20090324729A1 (en) * 2008-05-02 2009-12-31 Gilead Sciences, Inc. Use of solid carrier particles to improve the processability of a pharmaceutical agent
US20110000941A1 (en) * 2009-07-06 2011-01-06 Volk J Patrick Apparatus and System for Carrying a Digital Media Player

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060111933A1 (en) * 2003-10-09 2006-05-25 Steven Wheeler Adaptive medical decision support system
MY134672A (en) * 2004-05-20 2007-12-31 Japan Tobacco Inc Stable crystal of 4-oxoquinoline compound
US20060058286A1 (en) * 2004-09-16 2006-03-16 Mark Krystal Methods of treating HIV infection
WO2007092802A1 (en) * 2006-02-09 2007-08-16 Boehringer Ingelheim International Gmbh Method for treating hiv infection through co-administration of tipranavir and gs 9137

Patent Citations (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541206A (en) * 1989-05-23 1996-07-30 Abbott Laboratories Retroviral protease inhibiting compounds
US5196438A (en) * 1989-12-11 1993-03-23 Hoffmann-La Roche Inc. Amino acid derivatives
US5413999A (en) * 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US5914332A (en) * 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
US5849911A (en) * 1996-04-22 1998-12-15 Novartis Finance Corporation Antivirally active heterocyclic azahexane derivatives
US6087383A (en) * 1998-01-20 2000-07-11 Bristol-Myers Squibb Company Bisulfate salt of HIV protease inhibitor
US20050239819A1 (en) * 2002-11-20 2005-10-27 Motohide Satoh 4-Oxoquinoline compounds and utilization thereof as hiv integrase inhibitors
US20050288326A1 (en) * 2004-05-21 2005-12-29 Yuji Matsuzaki Combination therapy
US20090233964A1 (en) * 2005-12-30 2009-09-17 Gilead Sciences, Inc. Methods for improving the pharmacokinetics of hiv integrase inhibitors
US20070219243A1 (en) * 2005-12-30 2007-09-20 Kearney Brian P Method for improving the pharmacokinetics of HIV integrase inhibitors
US20090291952A1 (en) * 2006-07-07 2009-11-26 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
US20080125594A1 (en) * 2006-09-12 2008-05-29 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
US20110160458A1 (en) * 2006-09-12 2011-06-30 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
US20090093467A1 (en) * 2007-06-29 2009-04-09 Gilead Sciences, Inc. Therapeutic compositions and methods
US20100331331A1 (en) * 2007-06-29 2010-12-30 Therapeutic Compositons And Use Thereof Therapeutic compositions and the use thereof
US20090099366A1 (en) * 2007-09-11 2009-04-16 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
US20100292480A1 (en) * 2007-09-11 2010-11-18 Gilead Sciences, Inc Process and intermediates for preparing integrase inhibitors
US20090324729A1 (en) * 2008-05-02 2009-12-31 Gilead Sciences, Inc. Use of solid carrier particles to improve the processability of a pharmaceutical agent
US20110000941A1 (en) * 2009-07-06 2011-01-06 Volk J Patrick Apparatus and System for Carrying a Digital Media Player

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Edwin DeJesus et al, JAIDS, 2006, 43(1), 1-5. *
Katz et al, Drug and Alcohol Dependence, 2007, 91, 269-278. *

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070219243A1 (en) * 2005-12-30 2007-09-20 Kearney Brian P Method for improving the pharmacokinetics of HIV integrase inhibitors
US9139541B2 (en) 2006-07-07 2015-09-22 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
US7825252B2 (en) 2006-09-12 2010-11-02 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
US8796459B2 (en) 2006-09-12 2014-08-05 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
US8324244B2 (en) 2006-09-12 2012-12-04 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
US9891239B2 (en) * 2007-02-23 2018-02-13 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
US20100189687A1 (en) * 2007-02-23 2010-07-29 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
US20090093467A1 (en) * 2007-06-29 2009-04-09 Gilead Sciences, Inc. Therapeutic compositions and methods
US8440831B2 (en) 2007-09-11 2013-05-14 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
US8759525B2 (en) 2007-09-11 2014-06-24 Gilhead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
US8153801B2 (en) 2007-09-11 2012-04-10 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
US20100292480A1 (en) * 2007-09-11 2010-11-18 Gilead Sciences, Inc Process and intermediates for preparing integrase inhibitors
US20090099366A1 (en) * 2007-09-11 2009-04-16 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
WO2013082476A1 (en) 2011-11-30 2013-06-06 Emory University Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections
EP3750544A2 (en) 2011-11-30 2020-12-16 Emory University Jak inhibitors for use in the prevention or treatment of viral infection
US8877931B2 (en) 2012-08-03 2014-11-04 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors

Also Published As

Publication number Publication date
ZA201000468B (en) 2011-06-29
US20140343062A1 (en) 2014-11-20
NZ582089A (en) 2013-01-25
AU2008270634A1 (en) 2009-01-08
CA2691736A1 (en) 2009-01-08
AP2009005083A0 (en) 2009-12-31
US20110009411A1 (en) 2011-01-13
US20170136000A1 (en) 2017-05-18
IL202745A0 (en) 2010-06-30
AP2490A (en) 2012-10-04
EP2167089A1 (en) 2010-03-31
ECSP109889A (es) 2010-03-31
JP2015143277A (ja) 2015-08-06
UA103881C2 (ru) 2013-12-10
WO2009006203A1 (en) 2009-01-08
EA200971096A1 (ru) 2010-08-30
AR067184A1 (es) 2009-09-30
CO6251236A2 (es) 2011-02-21
TW200916103A (en) 2009-04-16
BRPI0813955A2 (pt) 2017-05-09
AU2008270634B2 (en) 2014-01-16
JP2013199494A (ja) 2013-10-03
SG182228A1 (en) 2012-07-30
JP2010532373A (ja) 2010-10-07
CN103356622A (zh) 2013-10-23
CN101743004A (zh) 2010-06-16
JP5547067B2 (ja) 2014-07-09
KR20100028656A (ko) 2010-03-12
MX2009013828A (es) 2010-03-10
JP5769762B2 (ja) 2015-08-26

Similar Documents

Publication Publication Date Title
US20090093482A1 (en) Therapeutic compositions and methods
AU2008270630B2 (en) Therapeutic compositions and the use thereof
CA2635468C (en) Methods for improving the pharmacokinetics of hiv integrase inhibitors
US20090233964A1 (en) Methods for improving the pharmacokinetics of hiv integrase inhibitors

Legal Events

Date Code Title Description
AS Assignment

Owner name: GILEAD SCIENCES, INC., CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:KEARNEY, BRIAN P.;MATHIAS, ANITA A.;REEL/FRAME:021991/0041;SIGNING DATES FROM 20081203 TO 20081215

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION