US20080169646A1 - Barb clamp with smooth bore - Google Patents
Barb clamp with smooth bore Download PDFInfo
- Publication number
- US20080169646A1 US20080169646A1 US12/034,279 US3427908A US2008169646A1 US 20080169646 A1 US20080169646 A1 US 20080169646A1 US 3427908 A US3427908 A US 3427908A US 2008169646 A1 US2008169646 A1 US 2008169646A1
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- US
- United States
- Prior art keywords
- barb
- collet
- sleeve
- clamp
- circumferential portion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L37/00—Couplings of the quick-acting type
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L33/00—Arrangements for connecting hoses to rigid members; Rigid hose connectors, i.e. single members engaging both hoses
- F16L33/22—Arrangements for connecting hoses to rigid members; Rigid hose connectors, i.e. single members engaging both hoses with means not mentioned in the preceding groups for gripping the hose between inner and outer parts
- F16L33/225—Arrangements for connecting hoses to rigid members; Rigid hose connectors, i.e. single members engaging both hoses with means not mentioned in the preceding groups for gripping the hose between inner and outer parts a sleeve being movable axially
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M39/12—Tube connectors; Tube couplings for joining a flexible tube to a rigid attachment
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L27/00—Adjustable joints, Joints allowing movement
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L33/00—Arrangements for connecting hoses to rigid members; Rigid hose connectors, i.e. single members engaging both hoses
- F16L33/02—Hose-clips
- F16L33/10—Hose-clips with a substantially-radial tightening member
Definitions
- the present invention relates to a fastening device for a tubular body.
- the flexible tubing is connected to the source of the gaseous or liquid fluid, the delivery site of the fluid, or to flexible tubing. At the ends of the flexible tubing, it is necessary to provide a secure and leak proof connections. Although these requirements are necessary in all environments using flexible tubing, it is critical in the medical and pharmaceutical, food and beverage fields. In the medical and pharmaceutical fields flexible tubing and associated connections are used for luer fittings, quick connects, or sanitary fittings such as used in blood pumps, oxygen concentrators, sleep apnea equipment, medical transport containers, IV bags, etc. In some environments, and especially in the medical field, it is imperative to absolutely prohibit any liquids from getting between the tube and the connection fitting at the connection point. Any gap or abrupt change at the point of connection will entrap fluid, e.g. bio, blood, drugs, foodstuff, etc. This entrapment can cause growth of harmful bacteria.
- any gap or abrupt change at the point of connection will entrap fluid, e.g. bio, blood, drugs, foodstuff, etc.
- the present invention addresses the aforementioned concerns.
- the present invention is an improved barb clamp used for joining a flexible tube to a barb fitting or connector, or straight lumen without a barb. And, in particular, for joining flexible tube to a specially constructed barb fitting that provides minuscule or no transition differential between the inner diameter of the tubing and the inner diameter of the barb fitting.
- the barb fitting tapers to a termination point so that there is no transition between the inner diameter of the tube and the inner diameter of the barb fitting for preventing a pressure differential in the tube between a portion of the tube in the improved barb clamp and a portion of the tube outside of the barb clamp.
- FIG. 1 is a sectional view of a current barb clamp
- FIG. 2 is a partial sectional view of an alternative to the current barb clamp
- FIG. 3 is an elevational view of a collet for the current barb clamp
- FIG. 4 is a sectional view of a sleeve for the current barb clamp
- FIG. 5 is a sectional view of an improved barb clamp according to the present invention.
- FIG. 6 is a sectional view of an alternative embodiment of the improved barb clamp
- FIG. 7 is a perspective view of another alternative embodiment of the improved collet and sleeve.
- FIG. 8 is a perspective view of the embodiment shown in FIG. 7 having a portion sectioned off to illustrate certain figures;
- FIG. 9 is a sectional view of the collet and sleeve of the barb clamp shown in FIG. 7 in an unlocked position;
- FIG. 10 is a sectional view of the collet and sleeve shown in FIG. 7 in the locked position.
- FIG. 11 is a sectional view of the barb clamp shown in FIG. 10 locked onto a tube.
- FIGS. 1 and 2 show the current barb clamp connector 10 for coupling a barbed fitting 12 and a flexible tube 14 and discussed hereafter.
- the barb fitting 12 is generally made of a non-metal material which allows it to be heat welded to a proprolyene or ethylene medical or pharmaceutical bag. The same and similar materials can be used for biotech, pharmaceutical, medical, and foodstuff fitting connections and manifold applications.
- the fitting can also be made from other plastics and stainless steel when required.
- the barbed fitting 12 may encompass different configurations but will generally include at least one expanded or barbed end 16 for a 360° radial compression connection to the flexible tube 14 .
- the barb fitting 12 is preferably made from an FDA. (Food and Drug Administration) approved polypropylene, silicone, TPE, TPR, etc.
- the barb fitting 12 may also include a flanged portion 17 which defines a stop for the barb clamp 10 .
- the barb clamp 10 includes a collet 18 and a sleeve 20 .
- the collet 18 and the sleeve 20 are as shown in FIGS. 1-6 and are similar to the collet and sleeve discussed in U.S. patent application Ser. No. 10/100,519 filed on Mar. 18, 2002, now U.S. Pat. No. 6,796,586 issued on Sep. 28, 2004.
- the collet 18 is an essentially annular member having a through aperture 19 for receiving the end of a tube 14 therein.
- the sleeve 20 is also an annular member with a through aperture 21 for receiving the end of the tube 14 as well as having a diameter for also receiving the collet 18 therein.
- the collet 18 has an exterior surface 22 providing resilient means for radially contracting around the tube 14 .
- the collet 18 has a first end 23 forming a discontinuous annular ring.
- an annular groove 26 Moving toward the second end 24 and beyond the annular groove 26 , the collet forms eight resilient tangs 28 .
- the tangs 28 radially flare out or expand slightly at the second end 24 of the collet 18 .
- the tangs 28 begin to flare approximately at the mid section 27 of each tang 28 .
- the tangs 28 are formed by narrow through slots 25 extending from the second end 24 and terminating at the annular groove 26 .
- the slots 25 are shown in FIGS. 3 and 5 with rounded termination ends 25 a , however, the termination ends 25 a may have pointed ends, (not shown).
- a small ramping ledge 30 projects above each termination end 25 a of the narrow through slots 25 .
- the small ledges 30 provide added strength to the collet and also provide a stop means for the sleeve 20 , as will be discussed hereinafter.
- the eight tangs 28 form a resilient seal which allow the tangs to contract around a tubular member 14 .
- the through slots 29 may also have rounded termination ends 29 a as shown in FIGS. 3 and 5 or pointed termination ends (not shown).
- the through slots 29 provide resiliency to the first end 23 of the collet 18 without sacrificing durability.
- the interior surface 31 of the collet 18 is essentially smooth except for a shelf 32 equally positioned on each tang 28 at the mid-section 27 for reasons to be discussed further.
- the sleeve 20 has a smooth exterior annular surface 34 .
- the sleeve 20 has a first or bottom end 36 forming an arcuate base to facilitate assembly to the collet 18 .
- the interior surface 40 forms a slight outward taper at the second or top end 38 of the sleeve 20 .
- the interior surface 40 is essentially smooth throughout the length of the sleeve 20 except for an annular projection 42 that extends from the inner surface.
- the annular projection 42 is sized and positioned on the sleeve 20 for disposition within the annular groove 26 of the collet 18 to form a lock when the barb clamp 10 is engaged. Therefore, the annular projection 42 is positioned proximate to the second or top end 38 of the sleeve 20 .
- the sleeve 20 is first placed over the end of the tube 14 so that the second or top end 38 of the sleeve 20 is spaced furthest away from the tube end the collet 18 is then placed on the tube 14 so that the first end 23 of the collet 18 is closest to the sleeve 20 .
- the expanded end 16 of the barbed fitting 12 is then placed into the tube 14 .
- the expanded end 16 of the barbed fitting 12 is sized for being snugly received within the interior of the tube 14 .
- the collet 18 is then slid over the tube 14 having the expanded end 16 of the barbed fitting 12 therein.
- the shelves 32 located on the interior surface 31 of the collet 18 is a retainer which forms a radial 360° compression around the tube 14 and under the expanded end 16 of the barb fitting 12 so that the barb fitting 12 cannot easily move out of the tube 14 .
- the sleeve 20 is then slid over the collet 18 such that the first or bottom end 36 of the sleeve 20 initially encounters the first end 23 of the collet 18 .
- the tangs 28 on the collet 18 are pushed radially inwardly into the tube 14 and barbed fitting 12 , so that the annular shelf 32 of the collet 18 is pressed inwardly into the tube 14 and barbed fitting 12 to provide a tight seal therebetween and thereby lock the annular shelf 32 under the barb 16 .
- the sleeve 20 continues over the collet 18 until the annular projection 42 on the interior surface 40 of the sleeve 20 sits within the annular groove 26 of the collet 18 .
- the small ledges 30 on the exterior surface 34 of the collet 18 provides a stop and lock to prevent the annular projection 42 from moving out of annular groove 26 .
- the barb clamp 10 “clicks” when the collet 18 and sleeve 20 lock together. The barb clamp 10 can then only be removed with the aid of a tool so that disconnection and leakages are prevented.
- the improved barb clamp shown in FIGS. 5 and 6 has many of the same features as discussed with regard to FIGS. 1-4 .
- the improved barb clamp 10 further includes an engineered designed barb fitting 112 which is designed to maintain the same cross sectional area of the bore or fluid passageway 100 a in the barb clamp 110 as the cross-sectional area of the bore or fluid passageway 100 in the tube 14 outside of the barb clamp 10 .
- the fluid passageway 100 outside of the barb clamp 110 is defined by the inner bore of the tube 14 .
- the fluid passageway 100 a in the improved barb clamp 110 is defined by the inner bore of the barb fitting 112 , 212 . As can be seen in FIGS.
- the cross-sectional area of the fluid passageway 100 of the tube 14 is reduced within the barb clamp 10 as shown at 100 a in FIG. 1 .
- the free end 50 of the barb fining 12 in the prior art has a blunt end 52 with a thickness that causes a transition in the cross-sectional area of the fluid passageway 100 as the tubing 14 enters the barb clamp 10 and changes to the fluid passageway 100 a .
- One problem encountered when designing a barb connection is that it is generally necessary to have a smaller cross-sectional area of the bore in the barb fitting 12 in order to insert the barb fitting 12 into the tube 14 .
- the improved clamp 10 provides a barb fitting 112 , 212 that has essentially the same bore diameter as the tube 14 , but can also easily be inserted into the tube 14 .
- the barb fitting 112 , 212 has an engineered bore size that has the same cross-sectional area as the bore 100 of the tubing 14 .
- the improved barb fitting 112 , 212 are installed into a tube 14 , there is no transition between the inner diameter of the tubing 14 and the inner diameter of the fitting 112 .
- the free end 150 of the barb fitting 112 , 212 are gradually tapered to a sharp point 152 .
- the sharp point 152 on the free end 150 of the barb fitting 112 also allows for easy insertion of the barb fitting 112 into the tube 14 . As a result of this configuration, liquid material can never get between the barb fitting 112 , or 212 , and the tube 14 .
- FIG. 6 shows an alternative configuration of the barb clamp 110 which still maintains the same inner diameter of the passageway of the tube 14 whether the tube 14 is within the barb clamp or not.
- the barb fitting 212 may include a bumper stop 230 which is attached to the flange 17 to act as a separate stop for the tube 14 while the flange 17 defines another stop for the collet 18 , 218 and sleeve 20 .
- the collet 218 may also be modified to have a tapered end 240 to correspond with a tapered end 40 of the sleeve. Further the annular shelf 232 of the collet 218 may be reconfigured to extend further into the tube 14 for a sturdier grip.
- the collet 18 and sleeve 20 should be made of an FDA approved material if the barb clamp 10 is in a medical or pharmaceutical environment.
- the material should be resilient.
- the collet 18 is made of acetyl, silicon, or polypropylene.
- the sleeve 20 is preferably made of polycarbonate, silicon, or polypropylene.
- the components of the improved barb clamp are made of such material as polypropylene that can be sterilized in an autoclave for medical applications.
- Antimicrobial additives may also be added to the plastic material used in the manufacturing of at least one of the barb connector, collet, and sleeve.
- FIGS. 7-11 show an alternative configuration of the barb clamp 310 according to the present invention.
- the barb clamp 310 of this embodiment is made of the same materials as disclosed in the previous embodiments.
- a barb clamp 310 is assembled onto a tube 314 for maintaining the tube 314 in fixed connection.
- the barb connector or fitting 312 has a tubular configuration.
- the barb connector 312 has a smooth inner bore 313 with a constant diameter therethrough defining a fluid passageway therein.
- the constant diameter of the inner bore 313 of the barb connector 312 equals the predetermined inner diameter 315 of the flexible tube 314 .
- the barb connector 312 has a first end for disposing into one end of the flexible tube 314 .
- the first end 322 has an outer angular or ramping surface 323 that commences from the inner surface 313 and extends radially outward away from the inner surface 313 defining a sharp point at the terminating end of the first end 322 .
- the first end 322 of the barb connector 312 has no edge perpendicular to the fluid passageway of the barb connector 312 , and there is no pressure differential in the fluid passageway in the tube 314 inside or outside of the barb clamp 310 when installed.
- the angular surface 323 extends along the entire radial periphery of the first end 322 .
- the angular surface 323 terminates at a barbed point 324 formed along the exterior surface.
- the barb fitting 312 may also include a flanged portion 326 spaced from the first end 322 which acts as a stop for insertion of the barb connector 312 into the tube 314 .
- the configuration of the pointed first end 322 of the barb fitting 312 provides a constant fluid passage diameter of the tube 314 whether the fluid passageway in the tube 314 is inside or outside of the barb connector 312 .
- the barb clamp 310 includes a collet 318 and a sleeve 320 .
- the collet 310 and the sleeve 320 are as shown in FIGS. 7-11 .
- the collet 318 and sleeve 320 are connected together by frangible tabs 328 as will be discussed hereinafter.
- the collet 318 is an annular member having a through aperture 319 for receiving the end of the tube 314 therein.
- the outer surface 330 of the collet 318 has a bi-level configuration wherein the diameter of the outer surface 330 a adjacent the first end 332 is less than the diameter of the outer surface 330 b adjacent the second end 334 .
- the first and second outer surfaces 330 a , 330 b are separated and defined by a ledge 336 positioned at the midpoint of the collet 318 .
- the interior surface 319 of the collet 318 has an essentially smooth radial surface except at the first end 332 , wherein an annular ridge 338 is positioned.
- the annular ridge 338 is defined by a lead-in annular surface 340 that angles inwardly to the reduced diameter of the ridge 338 .
- the angle leading edge 340 facilitates the entry and assembly of the barbed end 322 of the connector 312 and tube 314 .
- the second end 334 of the collet 318 has a radial surface perpendicular to the fluid passageway.
- a plurality of the frangible tabs 328 are connected to and extend from the radial surface 334 of the second end. Opposing ends of the frangible tabs 328 are also connected to an inner surface of the sleeve 320 as will be discussed hereinafter.
- Elongate through slits 342 commence at and are opened to the first end 332 of the collet 318 .
- the plurality of slits 342 are equally spaced along the circumference of the collet 318 .
- the slits 342 have elongated lateral edges 343 a 343 b that are spaced from each other forming a gap therebetween.
- the slits 342 extend approximately o-thirds of the axial length way into the body of the collet 318 from the first end 332 .
- the slits 342 are positioned directly in alignment with the frangible tabs 328 .
- the second end 334 of the collet 318 also includes a plurality of through slits 344 .
- the slits 344 are configured the same as the slits 342 .
- the slits 344 also include lateral spaced edges 345 a , 345 b .
- the slits 344 extend and are opened to the second end 334 of the collet 318 and extend two-thirds of the axial length into the body of the collet 318 .
- the slits 344 are equally spaced between adjacent slits 342 . Therefore, there is a center portion of the collet 318 into which both sets of slits 342 , 344 extend.
- the slits 342 , 344 allow for a resilient seal around the tube 314 when the barb clamp 310 is in a locked position.
- the sleeve 320 has a smooth exterior surface 350 .
- the interior surface 351 of the sleeve has a radial lip 352 formed at the first end 354 of the sleeve.
- the interior surface 351 has an expanded radial section 358 adjacent to the lip 352 .
- the expanded section 358 has an expanded radial diameter for accommodating the second section 330 b of the exterior of the collet 318 when the barb clamp is in the locked position.
- the expanded section 358 terminates at a ledge 360 defined by a reduced diameter portion 362 . Axially, the reduced diameter portion 362 is followed by a ramped portion 364 that ramps outwardly to an expanded end portion 366 .
- the expanded end portion 366 is adjacent to the second end 356 of the sleeve 320 .
- Opposing end portions of the frangible tabs 328 are positioned and connected to the wall of the interior expanded end portion 366 of the sleeve.
- the connection of the frangible tabs 328 to the collet 318 and sleeve 320 form a gap 329 between the second end 356 of the sleeve 320 and the second end 334 of the collet 318 so that the frangible tabs 328 are the only connection between the collet and sleeve when the barb clamp is in the unlocked position.
- the position of the frangible tabs 328 relative to the collet 318 and sleeve 320 allow for breakage of the frangible tabs 328 from the collet 318 with a predetermined applied force.
- the attached collet 318 and sleeve 320 are slipped onto the end of the tube 314 with the sleeve 320 end placed on the tube 314 first.
- the barb fitting or connector 312 is inserted into the end of the tube 314 leading with the pointed barbed end 322 .
- the collet 318 is slid back over that end of the tube 314 enclosing both the end of the tube 314 and the barb connector 312 .
- a locking instrument can be used to break the frangible tabs 328 to detach the sleeve 320 from the collet 318 and slide the sleeve 320 over collet 318 .
- the tabs 328 are broken away from the collet 318 , the portions of the tabs 328 on the inside surface 366 of the sleeve remain in tact and connected to the sleeve 320 .
- the second end 334 of the collet 318 breaks off the frangible tab portions 328 attached to the inner surface 362 of the sleeve 320 .
- the second end 334 of the collet follows the ramp 364 ; and the slits 344 squeeze together eliminating the gap between the side edges 345 a , 345 b to provide a resilient seal around the tube 314 .
- the sleeve 320 continues to move over the collet 318 until the second end 334 of the collet 318 is locked and abuts below the radial lip 352 in the sleeve.
- the radial lip 352 stops further axial movement of the sleeve 320 relative to the collet 318 .
- the second outer surface 330 b of the collet 318 is adjacent to the expanded section 358 in the sleeve 320 .
- the ledge 336 on the collet 318 snaps over and is held on the inner ledge 360 of the sleeve 320 .
- the reduced diameter portion 362 of the sleeve 320 contracts the first section 330 a of the collet 318 and removes the gap between the side edges 343 a and 343 b of the slit 342 .
- the reduced section 362 is positioned to affect the contraction of each of the gaps 342 and 344 .
- the tab portions 328 that remain connected to the sleeve 320 grip the outer surface 330 a of the collet 318 adjacent to the first end 332 .
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- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Quick-Acting Or Multi-Walled Pipe Joints (AREA)
- Joints That Cut Off Fluids, And Hose Joints (AREA)
Abstract
Description
- This application is a Continuation-in-Part application of U.S. patent application Ser. No. 10/963,457 a pending application filed on Oct. 13, 2004 which claims priority of provisional patent application 60/512,231 filed on Oct. 17, 2003.
- The present invention relates to a fastening device for a tubular body.
- The transfer of fluid through flexible tubing is widely used in various environments. Ultimately, the flexible tubing is connected to the source of the gaseous or liquid fluid, the delivery site of the fluid, or to flexible tubing. At the ends of the flexible tubing, it is necessary to provide a secure and leak proof connections. Although these requirements are necessary in all environments using flexible tubing, it is critical in the medical and pharmaceutical, food and beverage fields. In the medical and pharmaceutical fields flexible tubing and associated connections are used for luer fittings, quick connects, or sanitary fittings such as used in blood pumps, oxygen concentrators, sleep apnea equipment, medical transport containers, IV bags, etc. In some environments, and especially in the medical field, it is imperative to absolutely prohibit any liquids from getting between the tube and the connection fitting at the connection point. Any gap or abrupt change at the point of connection will entrap fluid, e.g. bio, blood, drugs, foodstuff, etc. This entrapment can cause growth of harmful bacteria.
- The present invention addresses the aforementioned concerns. The present invention is an improved barb clamp used for joining a flexible tube to a barb fitting or connector, or straight lumen without a barb. And, in particular, for joining flexible tube to a specially constructed barb fitting that provides minuscule or no transition differential between the inner diameter of the tubing and the inner diameter of the barb fitting.
- In one aspect of the invention the barb fitting tapers to a termination point so that there is no transition between the inner diameter of the tube and the inner diameter of the barb fitting for preventing a pressure differential in the tube between a portion of the tube in the improved barb clamp and a portion of the tube outside of the barb clamp.
- Other applications of the present invention will become apparent to those skilled in the art when the following description of the best mode contemplated for practicing the invention is read in conjunction with the accompanying drawings.
- The description herein makes reference to the accompanying drawings wherein like reference numerals refer to like parts throughout the several views, and wherein:
-
FIG. 1 is a sectional view of a current barb clamp; -
FIG. 2 is a partial sectional view of an alternative to the current barb clamp; -
FIG. 3 is an elevational view of a collet for the current barb clamp; -
FIG. 4 is a sectional view of a sleeve for the current barb clamp; -
FIG. 5 is a sectional view of an improved barb clamp according to the present invention; -
FIG. 6 is a sectional view of an alternative embodiment of the improved barb clamp; -
FIG. 7 is a perspective view of another alternative embodiment of the improved collet and sleeve; -
FIG. 8 is a perspective view of the embodiment shown inFIG. 7 having a portion sectioned off to illustrate certain figures; -
FIG. 9 is a sectional view of the collet and sleeve of the barb clamp shown inFIG. 7 in an unlocked position; -
FIG. 10 is a sectional view of the collet and sleeve shown inFIG. 7 in the locked position; and -
FIG. 11 is a sectional view of the barb clamp shown inFIG. 10 locked onto a tube. -
FIGS. 1 and 2 show the currentbarb clamp connector 10 for coupling abarbed fitting 12 and aflexible tube 14 and discussed hereafter. Thebarb fitting 12 is generally made of a non-metal material which allows it to be heat welded to a proprolyene or ethylene medical or pharmaceutical bag. The same and similar materials can be used for biotech, pharmaceutical, medical, and foodstuff fitting connections and manifold applications. The fitting can also be made from other plastics and stainless steel when required. As seen inFIGS. 1 and 2 , thebarbed fitting 12 may encompass different configurations but will generally include at least one expanded or barbedend 16 for a 360° radial compression connection to theflexible tube 14. If thebarb clamp 10 is to be used in a medical or pharmaceutical environment, thebarb fitting 12 is preferably made from an FDA. (Food and Drug Administration) approved polypropylene, silicone, TPE, TPR, etc. Thebarb fitting 12 may also include a flangedportion 17 which defines a stop for thebarb clamp 10. - The
barb clamp 10 includes acollet 18 and asleeve 20. Thecollet 18 and thesleeve 20 are as shown inFIGS. 1-6 and are similar to the collet and sleeve discussed in U.S. patent application Ser. No. 10/100,519 filed on Mar. 18, 2002, now U.S. Pat. No. 6,796,586 issued on Sep. 28, 2004. - The
collet 18 is an essentially annular member having athrough aperture 19 for receiving the end of atube 14 therein. Thesleeve 20 is also an annular member with athrough aperture 21 for receiving the end of thetube 14 as well as having a diameter for also receiving thecollet 18 therein. - Looking at
FIG. 3 thecollet 18 has an exterior surface 22 providing resilient means for radially contracting around thetube 14. Thecollet 18 has afirst end 23 forming a discontinuous annular ring. Along the exterior surface 22 and adjacent to thefirst end 23 is anannular groove 26. Moving toward thesecond end 24 and beyond theannular groove 26, the collet forms eightresilient tangs 28. Thetangs 28 radially flare out or expand slightly at thesecond end 24 of thecollet 18. Thetangs 28 begin to flare approximately at themid section 27 of eachtang 28. Thetangs 28 are formed by narrow throughslots 25 extending from thesecond end 24 and terminating at theannular groove 26. Theslots 25 are shown inFIGS. 3 and 5 with rounded termination ends 25 a, however, the termination ends 25 a may have pointed ends, (not shown). - A small ramping ledge 30 projects above each termination end 25 a of the narrow through
slots 25. Thesmall ledges 30 provide added strength to the collet and also provide a stop means for thesleeve 20, as will be discussed hereinafter. Between eachsmall ledge 30 there is a recessedplanar portion 30 a extending into theannular groove 26. The eighttangs 28 form a resilient seal which allow the tangs to contract around atubular member 14. Between everyother tang 28 there is a throughslot 29 which extends from thefirst end 23 to the mid-section 27 of the associatedtang 28. Thethrough slots 29 may also have rounded termination ends 29 a as shown inFIGS. 3 and 5 or pointed termination ends (not shown). Thethrough slots 29 provide resiliency to thefirst end 23 of thecollet 18 without sacrificing durability. Theinterior surface 31 of thecollet 18 is essentially smooth except for ashelf 32 equally positioned on eachtang 28 at the mid-section 27 for reasons to be discussed further. - Looking at
FIG. 4 , thesleeve 20 has a smooth exteriorannular surface 34. Thesleeve 20 has a first orbottom end 36 forming an arcuate base to facilitate assembly to thecollet 18. Theinterior surface 40 forms a slight outward taper at the second ortop end 38 of thesleeve 20. Theinterior surface 40 is essentially smooth throughout the length of thesleeve 20 except for anannular projection 42 that extends from the inner surface. Theannular projection 42 is sized and positioned on thesleeve 20 for disposition within theannular groove 26 of thecollet 18 to form a lock when thebarb clamp 10 is engaged. Therefore, theannular projection 42 is positioned proximate to the second ortop end 38 of thesleeve 20. - The
sleeve 20 is first placed over the end of thetube 14 so that the second ortop end 38 of thesleeve 20 is spaced furthest away from the tube end thecollet 18 is then placed on thetube 14 so that thefirst end 23 of thecollet 18 is closest to thesleeve 20. The expandedend 16 of thebarbed fitting 12 is then placed into thetube 14. The expandedend 16 of thebarbed fitting 12 is sized for being snugly received within the interior of thetube 14. Thecollet 18 is then slid over thetube 14 having the expandedend 16 of thebarbed fitting 12 therein. Theshelves 32 located on theinterior surface 31 of thecollet 18 is a retainer which forms a radial 360° compression around thetube 14 and under the expandedend 16 of the barb fitting 12 so that the barb fitting 12 cannot easily move out of thetube 14. Thesleeve 20 is then slid over thecollet 18 such that the first orbottom end 36 of thesleeve 20 initially encounters thefirst end 23 of thecollet 18. As thesleeve 20 moves over thecollet 18, thetangs 28 on thecollet 18 are pushed radially inwardly into thetube 14 andbarbed fitting 12, so that theannular shelf 32 of thecollet 18 is pressed inwardly into thetube 14 andbarbed fitting 12 to provide a tight seal therebetween and thereby lock theannular shelf 32 under thebarb 16. Thesleeve 20 continues over thecollet 18 until theannular projection 42 on theinterior surface 40 of thesleeve 20 sits within theannular groove 26 of thecollet 18. Thesmall ledges 30 on theexterior surface 34 of thecollet 18 provides a stop and lock to prevent theannular projection 42 from moving out ofannular groove 26. Thebarb clamp 10 “clicks” when thecollet 18 andsleeve 20 lock together. Thebarb clamp 10 can then only be removed with the aid of a tool so that disconnection and leakages are prevented. - The improved barb clamp shown in
FIGS. 5 and 6 has many of the same features as discussed with regard toFIGS. 1-4 . However, theimproved barb clamp 10 further includes an engineered designed barb fitting 112 which is designed to maintain the same cross sectional area of the bore orfluid passageway 100 a in thebarb clamp 110 as the cross-sectional area of the bore orfluid passageway 100 in thetube 14 outside of thebarb clamp 10. Thefluid passageway 100 outside of thebarb clamp 110 is defined by the inner bore of thetube 14. Thefluid passageway 100 a in theimproved barb clamp 110 is defined by the inner bore of the barb fitting 112, 212. As can be seen inFIGS. 1 and 2 , the cross-sectional area of thefluid passageway 100 of thetube 14 is reduced within thebarb clamp 10 as shown at 100 a inFIG. 1 . The free end 50 of the barb fining 12 in the prior art has ablunt end 52 with a thickness that causes a transition in the cross-sectional area of thefluid passageway 100 as thetubing 14 enters thebarb clamp 10 and changes to thefluid passageway 100 a. One problem encountered when designing a barb connection is that it is generally necessary to have a smaller cross-sectional area of the bore in the barb fitting 12 in order to insert the barb fitting 12 into thetube 14. However, theimproved clamp 10 provides a barb fitting 112, 212 that has essentially the same bore diameter as thetube 14, but can also easily be inserted into thetube 14. - In the
improved barb clamp 110, as shown inFIGS. 5 and 6 , the barb fitting 112, 212 has an engineered bore size that has the same cross-sectional area as thebore 100 of thetubing 14. When the improved barb fitting 112, 212 are installed into atube 14, there is no transition between the inner diameter of thetubing 14 and the inner diameter of the fitting 112. As a result, there is no pressure differential on the tubing or in the fluid from outside to inside of thebarb clamp 110. Maintaining a constant pressure or a constant velocity of fluid throughout the system may be imperative in certain medical applications. To accomplish this, thefree end 150 of the barb fitting 112, 212 are gradually tapered to asharp point 152. Thesharp point 152 on thefree end 150 of the barb fitting 112 also allows for easy insertion of the barb fitting 112 into thetube 14. As a result of this configuration, liquid material can never get between the barb fitting 112, or 212, and thetube 14. -
FIG. 6 shows an alternative configuration of thebarb clamp 110 which still maintains the same inner diameter of the passageway of thetube 14 whether thetube 14 is within the barb clamp or not. InFIG. 6 , it is shown that the barb fitting 212 may include abumper stop 230 which is attached to theflange 17 to act as a separate stop for thetube 14 while theflange 17 defines another stop for thecollet 18, 218 andsleeve 20. The collet 218 may also be modified to have atapered end 240 to correspond with atapered end 40 of the sleeve. Further theannular shelf 232 of the collet 218 may be reconfigured to extend further into thetube 14 for a sturdier grip. - The
collet 18 andsleeve 20 should be made of an FDA approved material if thebarb clamp 10 is in a medical or pharmaceutical environment. The material should be resilient. Preferably thecollet 18 is made of acetyl, silicon, or polypropylene. Thesleeve 20 is preferably made of polycarbonate, silicon, or polypropylene. The components of the improved barb clamp are made of such material as polypropylene that can be sterilized in an autoclave for medical applications. Antimicrobial additives may also be added to the plastic material used in the manufacturing of at least one of the barb connector, collet, and sleeve. -
FIGS. 7-11 show an alternative configuration of thebarb clamp 310 according to the present invention. Thebarb clamp 310 of this embodiment is made of the same materials as disclosed in the previous embodiments. Looking first aFIG. 11 , abarb clamp 310 is assembled onto atube 314 for maintaining thetube 314 in fixed connection. The barb connector or fitting 312 has a tubular configuration. Thebarb connector 312 has a smoothinner bore 313 with a constant diameter therethrough defining a fluid passageway therein. The constant diameter of theinner bore 313 of thebarb connector 312 equals the predeterminedinner diameter 315 of theflexible tube 314. Thebarb connector 312 has a first end for disposing into one end of theflexible tube 314. Thefirst end 322 has an outer angular or rampingsurface 323 that commences from theinner surface 313 and extends radially outward away from theinner surface 313 defining a sharp point at the terminating end of thefirst end 322. As a result, thefirst end 322 of thebarb connector 312 has no edge perpendicular to the fluid passageway of thebarb connector 312, and there is no pressure differential in the fluid passageway in thetube 314 inside or outside of thebarb clamp 310 when installed. Theangular surface 323 extends along the entire radial periphery of thefirst end 322. Theangular surface 323 terminates at abarbed point 324 formed along the exterior surface. The barb fitting 312 may also include aflanged portion 326 spaced from thefirst end 322 which acts as a stop for insertion of thebarb connector 312 into thetube 314. The configuration of the pointedfirst end 322 of the barb fitting 312 provides a constant fluid passage diameter of thetube 314 whether the fluid passageway in thetube 314 is inside or outside of thebarb connector 312. - The
barb clamp 310 includes acollet 318 and asleeve 320. Thecollet 310 and thesleeve 320 are as shown inFIGS. 7-11 . In the illustrated embodiment, thecollet 318 andsleeve 320 are connected together byfrangible tabs 328 as will be discussed hereinafter. Thecollet 318 is an annular member having a throughaperture 319 for receiving the end of thetube 314 therein. Theouter surface 330 of thecollet 318 has a bi-level configuration wherein the diameter of theouter surface 330 a adjacent thefirst end 332 is less than the diameter of theouter surface 330 b adjacent thesecond end 334. The first and secondouter surfaces ledge 336 positioned at the midpoint of thecollet 318. - The
interior surface 319 of thecollet 318 has an essentially smooth radial surface except at thefirst end 332, wherein anannular ridge 338 is positioned. Theannular ridge 338 is defined by a lead-inannular surface 340 that angles inwardly to the reduced diameter of theridge 338. Theangle leading edge 340 facilitates the entry and assembly of thebarbed end 322 of theconnector 312 andtube 314. Thesecond end 334 of thecollet 318 has a radial surface perpendicular to the fluid passageway. A plurality of thefrangible tabs 328 are connected to and extend from theradial surface 334 of the second end. Opposing ends of thefrangible tabs 328 are also connected to an inner surface of thesleeve 320 as will be discussed hereinafter. - Elongate through
slits 342 commence at and are opened to thefirst end 332 of thecollet 318. The plurality ofslits 342 are equally spaced along the circumference of thecollet 318. Theslits 342 have elongatedlateral edges 343 a 343 b that are spaced from each other forming a gap therebetween. Theslits 342 extend approximately o-thirds of the axial length way into the body of thecollet 318 from thefirst end 332. By example only, theslits 342 are positioned directly in alignment with thefrangible tabs 328. - The
second end 334 of thecollet 318 also includes a plurality of throughslits 344. Theslits 344 are configured the same as theslits 342. Theslits 344 also include lateral spacededges slits 344 extend and are opened to thesecond end 334 of thecollet 318 and extend two-thirds of the axial length into the body of thecollet 318. Theslits 344 are equally spaced betweenadjacent slits 342. Therefore, there is a center portion of thecollet 318 into which both sets ofslits slits tube 314 when thebarb clamp 310 is in a locked position. - The
sleeve 320 has a smoothexterior surface 350. Theinterior surface 351 of the sleeve has aradial lip 352 formed at thefirst end 354 of the sleeve. Theinterior surface 351 has an expandedradial section 358 adjacent to thelip 352. The expandedsection 358 has an expanded radial diameter for accommodating thesecond section 330 b of the exterior of thecollet 318 when the barb clamp is in the locked position. The expandedsection 358 terminates at aledge 360 defined by a reduceddiameter portion 362. Axially, the reduceddiameter portion 362 is followed by a rampedportion 364 that ramps outwardly to an expandedend portion 366. The expandedend portion 366 is adjacent to thesecond end 356 of thesleeve 320. Opposing end portions of thefrangible tabs 328 are positioned and connected to the wall of the interior expandedend portion 366 of the sleeve. The connection of thefrangible tabs 328 to thecollet 318 andsleeve 320 form agap 329 between thesecond end 356 of thesleeve 320 and thesecond end 334 of thecollet 318 so that thefrangible tabs 328 are the only connection between the collet and sleeve when the barb clamp is in the unlocked position. The position of thefrangible tabs 328 relative to thecollet 318 andsleeve 320 allow for breakage of thefrangible tabs 328 from thecollet 318 with a predetermined applied force. - For installation, the attached
collet 318 andsleeve 320 are slipped onto the end of thetube 314 with thesleeve 320 end placed on thetube 314 first. The barb fitting orconnector 312 is inserted into the end of thetube 314 leading with the pointedbarbed end 322. Once thebarb connector 312 is tightly installed into the end of thetube 314, thecollet 318 is slid back over that end of thetube 314 enclosing both the end of thetube 314 and thebarb connector 312. A locking instrument can be used to break thefrangible tabs 328 to detach thesleeve 320 from thecollet 318 and slide thesleeve 320 overcollet 318. Although thetabs 328 are broken away from thecollet 318, the portions of thetabs 328 on theinside surface 366 of the sleeve remain in tact and connected to thesleeve 320. - As the
sleeve 320 moves over thecollet 318, thesecond end 334 of thecollet 318 breaks off thefrangible tab portions 328 attached to theinner surface 362 of thesleeve 320. As thesleeve 320 continues its axial movement over thecollet 318, thesecond end 334 of the collet follows theramp 364; and theslits 344 squeeze together eliminating the gap between the side edges 345 a, 345 b to provide a resilient seal around thetube 314. Thesleeve 320 continues to move over thecollet 318 until thesecond end 334 of thecollet 318 is locked and abuts below theradial lip 352 in the sleeve. Theradial lip 352 stops further axial movement of thesleeve 320 relative to thecollet 318. In the locked position as shown inFIGS. 10 and 11 , the secondouter surface 330 b of thecollet 318 is adjacent to the expandedsection 358 in thesleeve 320. - The
ledge 336 on thecollet 318 snaps over and is held on theinner ledge 360 of thesleeve 320. The reduceddiameter portion 362 of thesleeve 320 contracts thefirst section 330 a of thecollet 318 and removes the gap between the side edges 343 a and 343 b of theslit 342. The reducedsection 362 is positioned to affect the contraction of each of thegaps tab portions 328 that remain connected to thesleeve 320 grip theouter surface 330 a of thecollet 318 adjacent to thefirst end 332. When thesleeve 320 is locked overcollet 318, the barb fitting 312 and thetube 314, there is a 360° radial compression connection of thetube 314. - While the invention has been described in connection with what is presently considered to be the most practical and preferred embodiment, it is to be understood that the invention is not to be limited to the disclosed embodiments but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims, which scope is to be accorded the broadest interpretation so as to encompass all such modifications and equivalent structures as is permitted under the law.
Claims (11)
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/034,279 US7922212B2 (en) | 2003-10-17 | 2008-02-20 | Barb clamp with smooth bore |
ES09712421.8T ES2575580T3 (en) | 2008-02-20 | 2009-01-16 | Toothed clamp with smooth hole |
CA2715635A CA2715635A1 (en) | 2008-02-20 | 2009-01-16 | Improved barb clamp with smooth bore |
PL09712421.8T PL2250422T3 (en) | 2008-02-20 | 2009-01-16 | Barb clamp with smooth bore |
KR1020107021000A KR101531903B1 (en) | 2008-02-20 | 2009-01-16 | Improved barb clamp with smooth bore |
PCT/US2009/031257 WO2009105296A2 (en) | 2008-02-20 | 2009-01-16 | Barb clamp with smooth bore |
CN2009801091715A CN101970925B (en) | 2008-02-20 | 2009-01-16 | Barb clamp with smooth bore |
JP2010547659A JP5679824B2 (en) | 2008-02-20 | 2009-01-16 | Improved barb clamp with smooth holes |
DK09712421.8T DK2250422T3 (en) | 2008-02-20 | 2009-01-16 | Modhageklemme smooth bore |
MX2010009088A MX2010009088A (en) | 2008-02-20 | 2009-01-16 | Barb clamp with smooth bore. |
EP09712421.8A EP2250422B1 (en) | 2008-02-20 | 2009-01-16 | Barb clamp with smooth bore |
US12/411,852 US7922213B2 (en) | 2003-10-17 | 2009-03-26 | Barb clamp with smooth bore |
US12/437,260 US8662542B2 (en) | 2003-10-17 | 2009-05-07 | Barb clamp with smooth bore |
US12/567,281 US8256802B2 (en) | 2003-10-17 | 2009-09-25 | Barb clamp with collet interlocks |
HK11102311.5A HK1148336A1 (en) | 2008-02-20 | 2011-03-08 | Barb clamp with smooth bore |
US14/171,368 US20140306447A1 (en) | 2003-10-17 | 2014-02-03 | Barb clamp with smooth bore |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51223103P | 2003-10-17 | 2003-10-17 | |
US10/963,457 US20050082826A1 (en) | 2003-10-17 | 2004-10-13 | Barb clamp |
US12/034,279 US7922212B2 (en) | 2003-10-17 | 2008-02-20 | Barb clamp with smooth bore |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/963,457 Continuation-In-Part US20050082826A1 (en) | 2003-10-17 | 2004-10-13 | Barb clamp |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/411,852 Continuation-In-Part US7922213B2 (en) | 2003-10-17 | 2009-03-26 | Barb clamp with smooth bore |
Publications (2)
Publication Number | Publication Date |
---|---|
US20080169646A1 true US20080169646A1 (en) | 2008-07-17 |
US7922212B2 US7922212B2 (en) | 2011-04-12 |
Family
ID=40986120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/034,279 Active 2025-11-02 US7922212B2 (en) | 2003-10-17 | 2008-02-20 | Barb clamp with smooth bore |
Country Status (12)
Country | Link |
---|---|
US (1) | US7922212B2 (en) |
EP (1) | EP2250422B1 (en) |
JP (1) | JP5679824B2 (en) |
KR (1) | KR101531903B1 (en) |
CN (1) | CN101970925B (en) |
CA (1) | CA2715635A1 (en) |
DK (1) | DK2250422T3 (en) |
ES (1) | ES2575580T3 (en) |
HK (1) | HK1148336A1 (en) |
MX (1) | MX2010009088A (en) |
PL (1) | PL2250422T3 (en) |
WO (1) | WO2009105296A2 (en) |
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- 2009-01-16 CN CN2009801091715A patent/CN101970925B/en active Active
- 2009-01-16 DK DK09712421.8T patent/DK2250422T3/en active
- 2009-01-16 ES ES09712421.8T patent/ES2575580T3/en active Active
- 2009-01-16 MX MX2010009088A patent/MX2010009088A/en active IP Right Grant
- 2009-01-16 EP EP09712421.8A patent/EP2250422B1/en active Active
- 2009-01-16 JP JP2010547659A patent/JP5679824B2/en active Active
- 2009-01-16 KR KR1020107021000A patent/KR101531903B1/en active IP Right Grant
- 2009-01-16 CA CA2715635A patent/CA2715635A1/en not_active Abandoned
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US8256802B2 (en) | 2003-10-17 | 2012-09-04 | Twin Bay Medical, Inc. | Barb clamp with collet interlocks |
US20090212559A1 (en) * | 2003-10-17 | 2009-08-27 | Twin Bay Medical, Inc. | Barb Clamp with Smooth Bore |
US20100013215A1 (en) * | 2003-10-17 | 2010-01-21 | Twin Bay Medical, Inc. | Barb Clamp with Collet Interlocks |
US7922212B2 (en) | 2003-10-17 | 2011-04-12 | Twin Bay Medical, Inc. | Barb clamp with smooth bore |
US7922213B2 (en) | 2003-10-17 | 2011-04-12 | Twin Bay Medical, Inc. | Barb clamp with smooth bore |
US8662542B2 (en) | 2003-10-17 | 2014-03-04 | Saint-Gobain Performance Plastics Corporation | Barb clamp with smooth bore |
US20090179422A1 (en) * | 2003-10-17 | 2009-07-16 | Twin Bay Medical, Inc. | Barb Clamp with Smooth Bore |
US9009927B2 (en) * | 2007-07-12 | 2015-04-21 | Etablissements Caillau | Automatically triggered tightening system for an elastic clamping collar |
US20100287740A1 (en) * | 2007-07-12 | 2010-11-18 | Etablissements Caillau | Automatically Triggered Tightening System for an Elastic Clamping Collar |
EP2414031A2 (en) * | 2009-04-02 | 2012-02-08 | Twin Bay Medical, Inc. | Sanitary retainer |
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US20100253075A1 (en) * | 2009-04-02 | 2010-10-07 | Twin Bay Medical, Inc. | Sanitary Retainer |
US9605782B2 (en) | 2009-04-02 | 2017-03-28 | Saint-Gobain Performance Plastics Corporation | Sanitary retainer |
US10619772B2 (en) | 2009-04-02 | 2020-04-14 | Saint-Gobain Performance Plastics Corporation | Sanitary retainer |
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ITBO20110335A1 (en) * | 2011-06-09 | 2012-12-10 | Co Ri M A S R L | CONNECTING DEVICE THAT CAN BE USED IN STERILE ENVIRONMENTS TO CONNECT A RADALLY DEFORMABLE DUCT |
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US20140215789A1 (en) * | 2013-02-06 | 2014-08-07 | Mark H. Becker | Rotational Locking and Attachment Mechanism |
US10639466B2 (en) | 2015-03-20 | 2020-05-05 | Saint-Gobain Performance Plastics Corporation | Connection-free filter capsule apparatus |
US10653980B2 (en) | 2016-03-21 | 2020-05-19 | Saint-Gobain Performance Plastics Corporation | Connection-free filter capsule apparatus |
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Also Published As
Publication number | Publication date |
---|---|
MX2010009088A (en) | 2010-10-15 |
JP2011515626A (en) | 2011-05-19 |
US7922212B2 (en) | 2011-04-12 |
CA2715635A1 (en) | 2009-08-27 |
WO2009105296A3 (en) | 2009-10-15 |
EP2250422A4 (en) | 2014-06-25 |
EP2250422A2 (en) | 2010-11-17 |
PL2250422T3 (en) | 2016-10-31 |
JP5679824B2 (en) | 2015-03-04 |
CN101970925A (en) | 2011-02-09 |
DK2250422T3 (en) | 2016-07-25 |
HK1148336A1 (en) | 2011-09-02 |
EP2250422B1 (en) | 2016-04-20 |
KR101531903B1 (en) | 2015-06-26 |
KR20100126413A (en) | 2010-12-01 |
ES2575580T3 (en) | 2016-06-29 |
CN101970925B (en) | 2012-10-03 |
WO2009105296A2 (en) | 2009-08-27 |
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