US20060111660A1 - Valve designs for left ventricular conduits - Google Patents

Valve designs for left ventricular conduits Download PDF

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Publication number
US20060111660A1
US20060111660A1 US11/300,513 US30051305A US2006111660A1 US 20060111660 A1 US20060111660 A1 US 20060111660A1 US 30051305 A US30051305 A US 30051305A US 2006111660 A1 US2006111660 A1 US 2006111660A1
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United States
Prior art keywords
conduit
heart
device
valve
coronary artery
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Abandoned
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US11/300,513
Inventor
Scott Wolf
Greg Furnish
Todd Hall
David Phelps
Peter Wilk
Nancy Briefs
William Santamore
Daniel Burkhoff
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HORIZON TECHNOLOGY FUNDING Co LLC
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Percardia Inc
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Publication date
Priority to US9977798P priority Critical
Priority to US09/368,393 priority patent/US6641610B2/en
Priority to US10/463,798 priority patent/US7011095B2/en
Application filed by Percardia Inc filed Critical Percardia Inc
Priority to US11/300,513 priority patent/US20060111660A1/en
Publication of US20060111660A1 publication Critical patent/US20060111660A1/en
Assigned to HORIZON TECHNOLOGY FUNDING COMPANY LLC reassignment HORIZON TECHNOLOGY FUNDING COMPANY LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: PERCARDIA, INC.
Assigned to WILK PATENT DEVELOPMENT CORPORATION reassignment WILK PATENT DEVELOPMENT CORPORATION ASSET PURCHASE AGREEMENT Assignors: PERCARDIA, INC.
Application status is Abandoned legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/94Stents retaining their form, i.e. not being deformable, after placement in the predetermined place
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2493Transmyocardial revascularisation [TMR] devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/848Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/958Inflatable balloons for placing stents or stent-grafts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2002/821Ostial stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0067Three-dimensional shapes conical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0073Quadric-shaped
    • A61F2230/0078Quadric-shaped hyperboloidal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0073Quadric-shaped
    • A61F2230/008Quadric-shaped paraboloidal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22Valves or arrangement of valves
    • A61M39/24Check- or non-return valves

Abstract

Disclosed is a conduit that provides a bypass around a stenosis or occlusion in a coronary artery. The conduit is adapted to be positioned in the myocardium to provide a passage for blood to flow from a heart chamber to a coronary artery, at a site distal to the blockage or stenosis in the coronary artery. The conduit has a one-way valve positioned therein to prevent the backflow of blood from the coronary artery into the heart chamber.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • This is a continuation of U.S. patent application Ser. No. 10/463,798, filed Jun. 18, 2003, now pending, which is a continuation application of U.S. patent application Ser. No. 09/368,393, filed on Aug. 4, 1999, now U.S. Pat. No. 6,641,610, and claims the benefit of U.S. Provisional Patent Application Ser. No. 60/099,777, filed Sep. 10, 1998, all of which are incorporated herein by reference.
  • FIELD OF THE INVENTION
  • This invention relates to apparatus and method for implanting a conduit to allow communication of fluids from one portion of a patient's body to another; and, more particularly, to a blood flow conduit to allow communication from a heart chamber to a vessel or vice versa, and/or vessel to vessel. Even more particularly, the invention relates to a left ventricular conduit and related conduit configurations for controlling the flow of blood through the conduit to achieve bypass of a stenosed or occluded coronary artery.
  • BACKGROUND OF THE INVENTION
  • Coronary artery disease is a major problem in the U.S. and throughout the world. Coronary arteries as well as other blood vessels frequently become clogged with plaque, which at the very least impairs the efficiency of the heart's pumping action, and can lead to heart attack, arrhythmias, and death. In some cases, these arteries can be unblocked through noninvasive techniques such as balloon angioplasty. In more difficult cases, a bypass of the blocked vessel is necessary.
  • In a bypass operation, one or more venous segments are inserted between the aorta and the coronary artery. The inserted venous segments or transplants act as a bypass of the blocked portion of the coronary artery and thus provide for a free or unobstructed flow of blood to the heart. More than 500,000 bypass procedures are performed in the U.S. every year.
  • Such coronary artery bypass surgery, however, is a very intrusive procedure that is expensive, time-consuming and traumatic to the patient. The operation requires an incision through the patient's sternum (stemotomy), and that the patient be placed on a bypass pump so that the heart can be operated on while not beating. A vein graft is harvested from the patient's leg, and a delicate surgical procedure is required to piece the bypass graft to the coronary artery (anastomosis). Hospital stays subsequent to the surgery and convalescence are prolonged. Furthermore, many patients are poor surgical candidates due to other concomitant illnesses.
  • As mentioned above, another conventional treatment is percutaneous transluminal coronary angioplasty (PTCA) or other types of angioplasty. However, such vascular treatments are not always indicated due to the type of location of the blockage or stenosis, or due to the risk of emboli.
  • Thus, there is a need for an improved bypass system that is less traumatic to the patient.
  • SUMMARY OF THE INVENTION
  • The preferred embodiments of the present invention address the need in the previous technology by providing a bypass system that avoids the stemotomy and other intrusive procedures normally associated with coronary bypass surgery. These embodiments also free the surgeon from the need to perform multiple anastomoses as is necessary in the current process.
  • The preferred device provides a conduit or shunt for diverting blood directly from the left ventricle of the heart to a coronary artery, at a point distal to the blockage or stenosis, thereby bypassing the blocked portion of the vessel. The conduit preferably comprises a tube adapted to be positioned in the myocardium and having a one way valve therein. The valve prevents the backflow of blood from the coronary artery into the left ventricle.
  • The conduit device is delivered through the coronary artery to a position distal the blockage or stenosis. At that position, the coronary artery, the myocardium and the wall of the left ventricle are pierced to provide an opening or channel completely through from the coronary artery to the left ventricle of the heart. The conduit is then positioned in the opening to provide a permanent passage for blood to flow between the left ventricle of the heart and the coronary artery, distal to the blockage or stenosis. The conduit is sized so that one open end is positioned within the coronary artery, while the other open end is positioned in the left ventricle. The hollow lumen of the conduit provides a passage for the flow of blood.
  • To prevent the backflow of blood from the coronary artery to the left ventricle of the heart, the conduit is provided with a one-way valve. The valve is preferably a windsock type valve, a flapper valve, a bi- or tricuspid valve, a ball valve, a valve formed from the myocardium itself, or a valve that opens and closes in response to the contraction and relaxation of the heart muscle, or in response to the electrical signals in the heart.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1A is a schematic, cross-sectional view of a human heart, showing a conduit in the myocardium of the heart for forming a bypass between the left ventricle and a coronary artery;
  • FIG. 1B is an enlarged view of the bypass conduit of FIG. 1A;
  • FIG. 2 is a cross-sectional view of a windsock valve incorporated into a heart conduit in accordance with a preferred arrangement;
  • FIG. 3 is a perspective view of a flapper valve incorporated into a heart conduit in accordance with a preferred arrangement;
  • FIG. 4 is a perspective view of a tricuspid valve incorporated into a heart conduit in accordance with the preferred arrangement;
  • FIGS. 5A-D are cross-sectional views of a valve formed from the myocardium for use in conjunction with a heart conduit in accordance with a preferred arrangement;
  • FIGS. 6A-B are cross-sectional views of a valve that is activated by the contractions of the heart muscle for use in conjunction with a heart conduit in accordance with a preferred arrangement;
  • FIG. 7 is a cross-sectional view of a valve that is activated by the electrical signals in the heart muscle for use in conjunction with a heart conduit in accordance with a preferred arrangement;
  • FIG. 8 is a cross-sectional view of a ball valve incorporated into a heart conduit in accordance with a preferred arrangement;
  • FIG. 9A-9B are cross-sectional views of a valve with spring mechanisms incorporated into a heart conduit;
  • FIGS. 9C-9D are cross-sectional views of a valve with a balloon mechanism incorporated into a heart conduit;
  • FIGS. 9E-9F are cross-sectional views of a valve with an internal motor incorporated into a heart conduit;
  • FIG. 10A is a partial cross-sectional view of a ball and cage valve incorporated into a heart conduit;
  • FIG. 10B is a cross-sectional view of a ball valve incorporated into a heart conduit having a narrower distal end;
  • FIG. 10C is a cross-sectional view of a ball valve incorporated into a heart conduit having a smooth taper.
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
  • As is well known, the coronary artery branches off the aorta and is positioned along the external surface of the heart wall. Oxygenated blood that has returned from the lungs to the heart then flows from the heart to the aorta. Some blood in the aorta flows into the coronary arteries, and the remainder of blood in the aorta flows on to the remainder of the body. The coronary arteries are the primary blood supply to the heart muscle and are thus critical to life. In some individuals, atherosclerotic plaque, aggregated platelets, and/or thrombi build up within the coronary artery, blocking the free flow of blood and causing complications ranging from mild angina to heart attack and death. The presence of coronary vasospasm, also known as “variant angina” or “Prinzmetal's angina,” compounds this problem in many patients.
  • As used herein, the term “heart chamber” primarily refers to the interior, or lumenal, aspect of the left or right ventricle or the left or right atrium. The term “conduit,” “stent,” and “tube” herein refer to physical structures, preferably primarily artificial, that can be positioned between two or more chambers or vessels, to allow blood flow from one chamber or vessel to another. A “shunt” is any natural or artificial passage between natural channels, such as heart chambers or blood vessels. The conduit in the preferred arrangement can be made of a variety of materials, including various metals, such as nitinol, or plastics.
  • As used herein, the term “heart wall” comprises any one or more of the following portions or layers of the mammalian heart: the epicardium, myocardium, endocardium, pericardium, interatrial septum, and interventricular septum
  • The principles of the present invention are not limited to left ventricular conduits, and include conduits for communicating bodily fluids from any space within a patient to another space within a patient, including any mammal. Furthermore, such fluid communication through the conduits is not limited to any particular direction of flow and can be antegrade or retrograde with respect to the normal flow of fluid. Moreover, the conduits may communicate between a bodily space and a vessel or from one vessel to another vessel (such as an artery to a vein or vice versa). Moreover, the conduits can reside in a single bodily space so as to communicate fluids from one portion of the space to another. For example, the conduits can be used to achieve a bypass within a single vessel, such as communicating blood from a proximal portion of an occluded coronary artery to a more distal portion of that same coronary artery.
  • In addition, the conduits and related methods can preferably traverse various intermediate destinations and are not limited to any particular flow sequence. For example, in one preferred embodiment of the present invention, the conduit communicates from the left ventricle, through the myocardium, into the pericardial space, and then into the coronary artery. However, other preferred embodiments are disclosed, including direct transmyocardial communication from a left ventricle, through the myocardium and into the coronary artery. Thus, as emphasized above, the term “transmyocardial” should not be narrowly construed in connection with the preferred fluid communication conduits, and other nonmyocardial and even noncardiac fluid communication are preferred as well. With respect to the walls of the heart (and more specifically the term “heart wall”), the preferred conduits and related methods are capable of fluid communication through all such walls including, without limitation, the. pericardium, epicardium, myocardium, endocardium, septum, etc.
  • The bypass which is achieved with certain preferred embodiments and related methods is not limited to a complete bypass of bodily fluid flow, but can also include a partial bypass which advantageously supplements the normal bodily blood flow. Moreover, the obstructions that are bypassed may be of a partial or complete nature, and therefore the terminology “bypass” or “occlusion” should not be construed to be limited to a complete bypass or a complete occlusion but can include partial bypass and partial occlusion as described.
  • The preferred conduits and related methods disclosed herein can also provide complete passages or partial passages through bodily tissues. In this regard, the conduits can comprise stents, shunts, or the like, and therefore provide a passageway or opening for bodily fluid such as blood. Moreover, the conduits are not necessarily stented or lined with a device but can comprise mere tunnels or openings formed in the tissues of the patient.
  • The conduits of the present invention preferably comprise both integral or one-piece conduits as well as plural sections joined together to form a continuous conduit. The present conduits can be deployed in a variety of methods consistent with sound medical practice including vascular or surgical deliveries, including minimally invasive techniques. For example, various preferred embodiments of delivery rods and associated methods are disclosed. In one-embodiment, the delivery rod is solid and trocar-like. It may be rigid or semi-rigid and capable of penetrating the tissues of the patient and thereby form the conduit, in whole or in part, for purposes of fluid communication. In other preferred embodiments, the delivery rods may be hollow so as to form the conduits themselves (e.g., the conduits are preferably self-implanting or self-inserting) or have a conduit mounted thereon (e.g., the delivery rod is preferably withdrawn leaving the conduit installed). Thus, the preferred conduit device and method for installation is preferably determined by appropriate patient indications in accordance with sound medical practices.
  • In order to restore the flow of oxygenated blood through the coronary artery, the preferred arrangement provides for the shunting of blood directly from the heart to a site in the coronary artery which is distal the blockage or stenosis.
  • Although the specification herein will describe the conduit primarily with reference to the left ventricle, the preferred arrangement can be used with any of the four heart chambers, and with any coronary artery, including the left main coronary artery, the right coronary artery, the left anterior descending artery, the left circumflex artery, the posterior descending artery, the obtuse marginal branch or a diagonal branch.
  • A tunnel or opening is formed through the wall of the coronary artery and the heart wall and into the left ventricle of the heart which lies beneath, or deep to, the coronary artery. A conduit is positioned in the opening to keep it open, and a one-way valve is positioned within the conduit to prevent blood from flowing back into the left ventricle of the heart from the coronary artery.
  • The conduit may be introduced into the heart wall in a variety of ways, including by a catheter threaded through the femoral artery into the aorta and thence into the left ventricle and, if necessary, the left atrium; or by a catheter threaded through the femoral vein into the inferior vena cava and thence into the night atrium and right ventricle. Alternatively, the conduit may be introduced through a surgical incision in chest wall (thoracotomy) or sternum (sternotomy).
  • Further details regarding conduits and conduit delivery systems are described in U.S. patent applications entitled DELIVERY METHODS FOR LEFT VENTRICULAR CONDUIT U.S. application Ser. No. 09/368,868, now U.S. Pat. No. 6,261,304; DESIGNS FOR LEFT VENTRICULAR CONDUIT U.S. application Ser. No. 09/369,048, now U.S. Pat. No. 6,290,728; LEFT VENTRICULAR CONDUIT WITH BLOOD VESSEL GRAFT U.S. application Ser. No. 09/369,061, now U.S. Pat. No. 6,254,564; LEFT VENTRICULAR CONDUITS TO CORONARY ARTERIES AND METHODS FOR CORONARY BYPASS U.S. application Ser. No. 09/369,039, now abandoned, and BLOOD FLOW CONDUIT DELIVERY SYSTEM AND METHOD OF USE U.S. application Ser. No. 09/368,644, now U.S. Pat. No. 6,302,892, filed on the same day as the present application, and U.S. Pat. Nos. 5,429,144, and 5,662,124, the disclosures of which are all hereby incorporated by reference in their entirety.
  • The opening through the heart wall (including endocardium, myocardium, and epicardium) and coronary artery can be formed in a variety of ways, including by knife or scalpel, electrocautery, cryoablation, radiofrequency ablation, ultrasonic ablation, and the like. Other methods will be apparent to those of ordinary skill in the art.
  • Referring now to FIGS. 1A and 1B, a coronary artery bypass is accomplished by disposing a conduit 12 (FIG. 1B) in a heart wall or myocardium MYO of a patient's heart PH (FIG. 1A). The conduit 12 preferably extends from the left ventricle LV of heart PH to a clogged coronary artery CA at a point downstream of a blockage BL to create a passageway therethrough. Conduit 12 is preferably made of a biocompatible material such as stainless steel or nitinol, although other materials such as Ti, Ti alloys, Ni alloys, Co alloys and biocompatible polymers may also be used. In one embodiment, conduit 12 has a one way valve 14 to allow blood to flow from the left ventricle LV to the coronary artery CA. Although the conduit 12 may elastically deform under the contractive pressure of the heart muscle during systole, the stent remains open to allow blood to pass from the patient's left ventricle LV into the coronary artery CA. During diastole, the blood pumped into coronary artery through passageway is blocked by one-way valve 14 from returning to left ventricle LV.
  • One embodiment of the preferred arrangement is illustrated in FIG. 2. The valve 10 incorporates a design similar to a windsock. The valve 10 is preferably formed from a biocompatible fabric-like material incorporated during the construction of the conduit 12. The high-pressure blood flow causes the valve 10 to open, while the backflow of blood catches the edges of the valve 10 and causes it to close, stopping the flow. The valve 10 can be positioned anywhere along the length of the conduit 12.
  • The valve 10 is preferably constructed from a biocompatible and very compliant fabric or other material that is pushed aside by the high forward blood pressure created from the contraction of the heart muscle, but opens to “catch” the back-flow of blood passing back through the conduit 12. The valve 10 is preferably constructed by incorporating the fabric or other material into the conduit 12 directly during its manufacture. This allows the valve 10 and conduit 12 to be introduced as a single unit.
  • Another embodiment of the preferred arrangement is illustrated in FIG. 3. This valve 15 is a type of “flapper valve” that is built onto the end of the conduit 12 that is positioned in the coronary artery. The high-pressure blood flow opens the flap 15 and the backflow of blood causes the flap 15 to shut. This flap 15 is slightly larger than the conduit 12 inner diameter (ID) to accomplish this action and to ensure a proper seal. The valve 15 is preferably formed from the same material as the conduit 12 and the two are preferably introduced as a single unit. Alternatively, the valve 15 may be attached as a secondary operation once the conduit 12 is in place.
  • The third embodiment of the valve 16 is illustrated in FIG. 4. This valve 16 is similar to a natural heart valve. A bi- or tricuspid arrangement of semi-circular spheres is forced open by the high-pressure flow and collapses back to prevent backflow of blood through the conduit 12. This valve 16 is preferably made from the same material as the conduit 12, or alternatively, from a thin biocompatible material that is built onto the conduit 12. Preferably, the valve 16 and the conduit 12 are manufactured together and introduced as a single unit. Alternatively, the valve 16 may be attached to the conduit 12 in a secondary operation once the conduit 12 is in place. The valve 16 may be placed at any location along the length of the conduit 12.
  • A further embodiment of the conduit is illustrated in FIGS. 5A-D. Here, the heart wall, which includes the myocardium MYO, lying between the coronary artery CA and the left ventricle of the heart LV, is cut using known techniques to form a passage through the myocardium MYO. FIG. 5A shows the myocardium MYO after a cut or puncture has been made in it, with a free edge 17 shown at each margin of the cut or puncture. FIG. 5B shows the myocardium MYO after a jagged or irregular surface 19 has been made with a cutting tool in the free edge 17 of the myocardium MYO. Such cutting tools may include knives, scalpels, lasers, radiofrequency probes, and other cutting tools known to those of skill in the art.
  • As illustrated in FIG. 5C, two conduits, an upper or lower conduit, or a single conduit 18 having upper 18 a and lower 18 b components, is positioned in the passage. The myocardium MYO is left free between the two edges of the conduit 18 to form the valve 20. FIG. 5D shows that during diastole, the edges or free portions of the myocardium MYO come together, closing the passage through the myocardium MYO. During systole, the free portions of the myocardium MYO can move away from one another as cardiac myofibrils contract, opening the passage through the myocardium MYO, as illustrated in FIG. 5C. Thus, the heart muscle MYO itself can form at least part of the valve 20 in the conduit 18 to prevent the backflow of blood.
  • In another embodiment, the valve in the conduit may be controlled in response to the contractions of the heart. As illustrated in FIGS. 6A and 6B, two conduits (FIG. 6A), an upper conduit 20 and lower conduit 22, or a single conduit (FIG. 6B) having upper moveable components 20 and lower moveable components 22, are positioned in the passage in the myocardium MYO between the left ventricle LV and the coronary artery CA. The conduit or conduits contain a valve 24, which is normally in a closed position, and an actuator 26, which is adapted to open the valve 24 in the conduit. During diastole, when the heart muscle MYO is relaxed, the two conduits or the two components of the conduit 20, 22 are positioned such that the valve 24 remains closed. During systole, the two conduits or components 20, 22 are brought close together, such that the actuator 26 forces the valve 24 to open and allows for the passage of blood therethrough. Thus, the contractions of the heart muscle MYO control the valve 24 in the conduit to prevent the backflow of blood during part of the cardiac cycle, for example diastole.
  • The valve 24 may also be controlled by a hydrodynamic or electric pump or motor, which is responsive to the contractions of the heart, causing the valve 24 to open and close in response to various parts of the cardiac cycle.
  • A further embodiment of the preferred arrangement is illustrated in FIG. 7. In this embodiment, electrical sensors 30 regulate the opening and closing of the valve 32 positioned within the conduit 34. The sensor 30 senses the electrical signals produced in the heart muscle, and causes the valve 32 to open during systole, and to close during diastole. This is accomplished by having an actuator 36 act in response to the electrical signals detected by the sensor 30, to open and close the valve 32. For example, the valve 32 can be biased in a closed position. When the sensor 30 detects the electrical signal that occurs during or immediately precedes systole, e.g., a QRS complex in the electrocardiogram, the sensor 30 signals the actuator 36 to force open the valve 32 and allow for the flow of blood therethrough. During diastole, the sensor 30 signals the actuator 36 to allow the valve 32 to close and prevent any backflow of blood. Alternatively, the valve 32 can be biased in an open position. When the sensor 30 senses diastole, such as through coordination with the P wave or PR interval in the electrocardiogram, or, for example, after the sensor delays for a predetermined time period after the QRS complex occurs in the electrocardiogram, it signals the actuator 36 to close the valve 32 and prevent the backflow of blood.
  • Another embodiment is illustrated in FIG. 8. This valve 42 is a type of “ball valve” that is built into the conduit 40 that is positioned in the coronary artery. The high-pressure blood flow from the left ventricle LV to the coronary artery CA opens the valve 42 by moving the ball 44 away from the opening 46. The backflow of blood from the coronary artery CA to the left ventricle LV causes the ball 44 to seat against the opening 46, thereby closing the valve 42 and preventing the backflow of blood. The valve 42 and the conduit 40 are preferably introduced as a single unit.
  • Another embodiment is illustrated in FIGS. 9A and 9B. The conduit 12 has a valve 48 with one or more spring mechanisms 50 within its walls. In diastole (FIG. 9A), bloodflow pressure through the valve is relatively low, and the valve assumes a relatively closed position, impeding the passage of blood through the valve 48. In systole (FIG. 9B), flow pressure through the valve is relatively high, and the valve 48 opens as the spring mechanism 50 contracts, to allow blood to flow through the valve 48.
  • Instead of a spring mechanism 50, the walls of the conduit 12 can have other mechanisms therein to allow differential flow during various parts of the cardiac cycle. For example, the valve 48 can have a gas- or liquid-filled balloon 52 in its wall, as shown in FIGS. 9C and 9D. This balloon mechanism can contract (FIG. 9D, during systole) or expand (FIG. 9C, during diastole) in response to fluid pressure, to allow the valve 48 to open and close, respectively. Alternatively, the valve 48 can have an internal motor 54, shown in FIGS. 9E and 9F, that opens and closes the valve 48 in response to electrical or mechanical signals from the heart during various parts of the cardiac cycle. For example, as illustrated in FIG. 9E, during diastole, the motor preferably closes the valve 48, and during systole, the motor preferably opens the valve 48.
  • Another embodiment of the valve mechanism is illustrated in FIG. 10A. The conduit 12 has a ball valve 60 that is of the ball-and-cage variety, for example, like the Starr-Edwards heart valve known to those of skill in the art. This valve 60 typically has a wire or mesh cage 62 with a ball 64 within it. The conduit is positioned within the myocardium MYO. During blood flow from the left ventricle LV to the coronary artery CA, the ball 64 moves toward the apex of the cage 62, permitting blood to flow around the ball 64 and through the conduit 12. During backflow of blood from the coronary artery CA to the left ventricle LV, the ball 64 moves toward the base of the cage 62 and seats thereon, fitting tightly onto the base of the cage 62, and blocking the flow of blood from the coronary artery CA to the left ventricle LV.
  • FIG. 10B illustrates another embodiment wherein a ball 64 is provided within a conduit 12 that is wider at proximal end 56 facing the left ventricle, and narrower at distal end 58 facing the, coronary artery. FIG. 10C illustrates a similar embodiment wherein the conduit 12 has a gradual taper from the proximal end 56 to distal end 58. Like the embodiment of FIG. 10A, during blood flow from the proximal end 56 to distal end 58, the ball 64 moves toward the coronary artery CA to allow blood flow around the ball through the conduit. In one embodiment, the cross-section of the conduit 12 in FIGS. 10B and 10C is noncircular, for example elliptical, to allow blood to flow around the ball 64. During backflow from the coronary artery CA to the left ventricle LV, the ball moves against the base 59 of the conduit to block flow of blood therethrough.
  • The present vascular conduit and valve system provides significant improvements in the present treatment of blockages and significant stenoses in the coronary artery. Although the invention has been described in its preferred embodiments in connection with the particular figures, it is not intended that this description should be limited in any way.

Claims (12)

1-35. (canceled)
36. A device for treating a heart, the device comprising:
a hollow implant having an interior wall surface defining a lumen, the hollow implant being configured to be positioned in a heart wall between a heart chamber and a coronary vessel so as to support a, blood flow passage between the heart chamber and the coronary vessel,
wherein portions of the interior wall surface are moveable relative to each other such that, during diastole, the portions reduce the cross-sectional area of the lumen so as to at least partially obstruct blood flow through the implant.
37. The device of claim 36, wherein the hollow implant is configured such that, when positioned in the heart wall, the lumen has a greater cross-sectional area during systole than during diastole at a location of the portions.
38. The device of claim 36, wherein the hollow implant includes a hollow tube.
39. The device of claim 36, wherein the hollow implant includes a stent.
40. The device of claim 36, wherein the hollow implant is configured to be positioned in the heart wall between a left ventricle and a blood vessel.
41. The device of claim 36, wherein the hollow implant is configured to be positioned in the heart wall between the heart chamber and a coronary artery.
42. The device of claim 36, wherein the hollow implant is configured to be positioned in the heart wall between a left ventricle and a coronary artery.
43. The device of claim 36, further comprising a mechanism positioned within the wall of the conduit so as to bias the portions of the interior wall surface toward each other during diastole.
44. The device of claim 43, wherein the mechanism is chosen from springs, inflatable structures, and means responsive to electrical and/or mechanical signals.
45. The device of claim 43, wherein the mechanism is configured to permit the interior wall surface portions to move away from each other during systole.
46. The device of claim 36, wherein other portions of the interior wall surface are substantially immovable such that, during the cardiac cycle, the other portions maintain a substantially constant cross-sectional area of the lumen.
US11/300,513 1998-09-10 2005-12-15 Valve designs for left ventricular conduits Abandoned US20060111660A1 (en)

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US9977798P true 1998-09-10 1998-09-10
US09/368,393 US6641610B2 (en) 1998-09-10 1999-08-04 Valve designs for left ventricular conduits
US10/463,798 US7011095B2 (en) 1998-09-10 2003-06-18 Valve designs for left ventricular conduits
US11/300,513 US20060111660A1 (en) 1998-09-10 2005-12-15 Valve designs for left ventricular conduits

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Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060253189A1 (en) * 2002-04-03 2006-11-09 Boston Scientific Corporation Artificial valve
US20080126131A1 (en) * 2006-07-17 2008-05-29 Walgreen Co. Predictive Modeling And Risk Stratification Of A Medication Therapy Regimen
US20090198315A1 (en) * 2006-04-28 2009-08-06 Younes Boudjemline Vascular Stents, Methods of Use and Methods of Manufacture
US7670368B2 (en) 2005-02-07 2010-03-02 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US7722666B2 (en) 2005-04-15 2010-05-25 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US7776053B2 (en) 2000-10-26 2010-08-17 Boston Scientific Scimed, Inc. Implantable valve system
US7780722B2 (en) 2005-02-07 2010-08-24 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US7780627B2 (en) 2002-12-30 2010-08-24 Boston Scientific Scimed, Inc. Valve treatment catheter and methods
US7799038B2 (en) 2006-01-20 2010-09-21 Boston Scientific Scimed, Inc. Translumenal apparatus, system, and method
US20100256776A1 (en) * 2005-01-19 2010-10-07 Gi Dynamics, Inc. Eversion Resistant Sleeves
US7854755B2 (en) 2005-02-01 2010-12-21 Boston Scientific Scimed, Inc. Vascular catheter, system, and method
US7854761B2 (en) 2003-12-19 2010-12-21 Boston Scientific Scimed, Inc. Methods for venous valve replacement with a catheter
US7867274B2 (en) 2005-02-23 2011-01-11 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US7892276B2 (en) 2007-12-21 2011-02-22 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
US7951189B2 (en) 2005-09-21 2011-05-31 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US7967853B2 (en) 2007-02-05 2011-06-28 Boston Scientific Scimed, Inc. Percutaneous valve, system and method
US8002824B2 (en) 2004-09-02 2011-08-23 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US8012198B2 (en) 2005-06-10 2011-09-06 Boston Scientific Scimed, Inc. Venous valve, system, and method
US8128681B2 (en) 2003-12-19 2012-03-06 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US8133270B2 (en) 2007-01-08 2012-03-13 California Institute Of Technology In-situ formation of a valve
US8828079B2 (en) 2007-07-26 2014-09-09 Boston Scientific Scimed, Inc. Circulatory valve, system and method
US9622859B2 (en) 2005-02-01 2017-04-18 Boston Scientific Scimed, Inc. Filter system and method
US9668859B2 (en) 2011-08-05 2017-06-06 California Institute Of Technology Percutaneous heart valve delivery systems
US9681948B2 (en) 2006-01-23 2017-06-20 V-Wave Ltd. Heart anchor device
US9707382B2 (en) 2009-05-04 2017-07-18 V-Wave Ltd. Device and method for regulating pressure in a heart chamber
US9713696B2 (en) 2013-05-21 2017-07-25 V-Wave Ltd. Apparatus and methods for delivering devices for reducing left atrial pressure
US9724499B2 (en) 2001-04-20 2017-08-08 V-Wave Ltd. Device and method for controlling in-vivo pressure
US9744037B2 (en) 2013-03-15 2017-08-29 California Institute Of Technology Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves
WO2018022862A1 (en) * 2016-07-27 2018-02-01 Sainath Intellectual Properties, Llc Stent with one-way sock valve
WO2018035151A1 (en) * 2016-08-15 2018-02-22 The Trustees Of Columbia University In The City Of New York Conduit to increase coronary blood flow
US9943670B2 (en) 2001-04-20 2018-04-17 V-Wave Ltd. Methods and apparatus for reducing localized circulatory system pressure
WO2018071373A1 (en) * 2016-10-10 2018-04-19 Kassab Ghassan S Devices and methods for treating congestive heart failure, ascites, and other disorders relating to excess bodily fluid
US9980815B2 (en) 2009-05-04 2018-05-29 V-Wave Ltd. Devices for reducing left atrial pressure, and methods of making and using same
US10076403B1 (en) 2009-05-04 2018-09-18 V-Wave Ltd. Shunt for redistributing atrial blood volume

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6196230B1 (en) * 1998-09-10 2001-03-06 Percardia, Inc. Stent delivery system and method of use
EP1669042A3 (en) * 1998-09-10 2006-06-28 Percardia, Inc. TMR shunt
US6290728B1 (en) 1998-09-10 2001-09-18 Percardia, Inc. Designs for left ventricular conduit
US6641610B2 (en) 1998-09-10 2003-11-04 Percardia, Inc. Valve designs for left ventricular conduits
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
US6261304B1 (en) 1998-09-10 2001-07-17 Percardia, Inc. Delivery methods for left ventricular conduit
US6409697B2 (en) * 1999-05-04 2002-06-25 Heartstent Corporation Transmyocardial implant with forward flow bias
US6302892B1 (en) * 1999-08-04 2001-10-16 Percardia, Inc. Blood flow conduit delivery system and method of use
US6253768B1 (en) 1999-08-04 2001-07-03 Percardia, Inc. Vascular graft bypass
US6605053B1 (en) 1999-09-10 2003-08-12 Percardia, Inc. Conduit designs and related methods for optimal flow control
US6458153B1 (en) * 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US8474460B2 (en) 2000-03-04 2013-07-02 Pulmonx Corporation Implanted bronchial isolation devices and methods
JP3782297B2 (en) * 2000-03-28 2006-06-07 株式会社東芝 A solid-state imaging device and manufacturing method thereof
FR2816826B1 (en) * 2000-11-17 2003-09-26 Laurent Jacquemin Device for correcting narrowing of the aortic valve of man without opening or stop the heart
US6596024B2 (en) * 2000-12-21 2003-07-22 Carbomedics Inc. Polymeric heart valve fabricated from polyurethane/polysiliconeurethane blends
CA2462509A1 (en) 2001-10-04 2003-04-10 Neovasc Medical Ltd. Flow reducing implant
US20020188170A1 (en) * 2001-04-27 2002-12-12 Santamore William P. Prevention of myocardial infarction induced ventricular expansion and remodeling
FR2827153A1 (en) * 2001-07-12 2003-01-17 Younes Boudjemline Closure for cardiopathic septal faults has hollow discoid body with central constriction forming tube with one way valve
US20030036698A1 (en) * 2001-08-16 2003-02-20 Robert Kohler Interventional diagnostic catheter and a method for using a catheter to access artificial cardiac shunts
JP4446739B2 (en) * 2001-10-11 2010-04-07 パルモンクス・コーポレイションPulmonx Corporation Using bronchial flow control device and the device
US20040089306A1 (en) * 2002-05-28 2004-05-13 Ronald Hundertmark Devices and methods for removing bronchial isolation devices implanted in the lung
US20080249504A1 (en) * 2007-04-06 2008-10-09 Lattouf Omar M Instrument port
US20030216801A1 (en) * 2002-05-17 2003-11-20 Heartstent Corporation Transmyocardial implant with natural vessel graft and method
US20030220661A1 (en) * 2002-05-21 2003-11-27 Heartstent Corporation Transmyocardial implant delivery system
US8348963B2 (en) 2002-07-03 2013-01-08 Hlt, Inc. Leaflet reinforcement for regurgitant valves
AT407629T (en) 2002-07-26 2008-09-15 Emphasys Medical Inc Bronchial flow device with a membrane seal
EP1592367B1 (en) 2002-08-28 2016-04-13 HLT, Inc. Method and device for treating diseased valve
GB0220242D0 (en) * 2002-09-02 2002-10-09 Aortech Internat Plc Blood regulation device
FR2846520B1 (en) * 2002-11-06 2006-09-29 Roquette Freres Use of branched maltodextrins as granulation binders
IL153753D0 (en) * 2002-12-30 2003-07-06 Neovasc Medical Ltd Varying-diameter vascular implant and balloon
US6928669B2 (en) * 2003-01-10 2005-08-16 Tyler Pipe Company Closet carrier system and method of assembly
EP1631828A1 (en) * 2003-06-12 2006-03-08 Analiza, Inc. Systems and methods for characterization of molecules
IES20030531A2 (en) 2003-07-17 2005-09-21 Medtronic Vascular Connaught Methods and devices for placing a fistula device in fluid communication with a target vessel
IES20030539A2 (en) 2003-07-22 2005-05-18 Medtronic Vascular Connaught Stents and stent delivery system
WO2005074384A2 (en) * 2004-02-10 2005-08-18 Yossi Gross Extracardiac blood flow amplification device
US8876791B2 (en) 2005-02-25 2014-11-04 Pulmonx Corporation Collateral pathway treatment using agent entrained by aspiration flow current
WO2015109328A2 (en) * 2014-01-17 2015-07-23 Correx, Inc. Apparatus and method for forming a hole in a hollow organ, connecting a conduit to the hollow organ and connecting a left ventricular assist device (lvad) to the hollow organ
US9138228B2 (en) * 2004-08-11 2015-09-22 Emory University Vascular conduit device and system for implanting
US7771472B2 (en) 2004-11-19 2010-08-10 Pulmonx Corporation Bronchial flow control devices and methods of use
US7927270B2 (en) 2005-02-24 2011-04-19 Ethicon Endo-Surgery, Inc. External mechanical pressure sensor for gastric band pressure measurements
US8152710B2 (en) 2006-04-06 2012-04-10 Ethicon Endo-Surgery, Inc. Physiological parameter analysis for an implantable restriction device and a data logger
US7699770B2 (en) 2005-02-24 2010-04-20 Ethicon Endo-Surgery, Inc. Device for non-invasive measurement of fluid pressure in an adjustable restriction device
US8870742B2 (en) 2006-04-06 2014-10-28 Ethicon Endo-Surgery, Inc. GUI for an implantable restriction device and a data logger
US8066629B2 (en) 2005-02-24 2011-11-29 Ethicon Endo-Surgery, Inc. Apparatus for adjustment and sensing of gastric band pressure
US7775966B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. Non-invasive pressure measurement in a fluid adjustable restrictive device
US7658196B2 (en) 2005-02-24 2010-02-09 Ethicon Endo-Surgery, Inc. System and method for determining implanted device orientation
US8016744B2 (en) 2005-02-24 2011-09-13 Ethicon Endo-Surgery, Inc. External pressure-based gastric band adjustment system and method
US7775215B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. System and method for determining implanted device positioning and obtaining pressure data
US20060271171A1 (en) * 2005-04-01 2006-11-30 Mcquinn Tim C Artificial heart valve
US8038720B2 (en) * 2005-10-18 2011-10-18 Wallace Jeffrey M Methods and devices for intragastrointestinal prostheses
US20070293808A1 (en) * 2006-04-27 2007-12-20 Williams Michael S Renal blood flow augmentation for congestive heart failure treatment
US20080051879A1 (en) * 2006-08-23 2008-02-28 Cook Incorporated Methods of treating venous valve related conditions with a flow-modifying implantable medical device
AU2010344182A1 (en) 2010-01-29 2012-08-16 Dc Devices, Inc. Devices and systems for treating heart failure
CN107334512A (en) 2011-02-10 2017-11-10 可维亚媒体公司 Apparatus to create and maintain an intra-atrial pressure relief opening
JP2010508093A (en) * 2006-11-07 2010-03-18 セラマジャー,デイヴィッド,スティーヴン Apparatus and method for treating heart failure
US8460372B2 (en) 2006-11-07 2013-06-11 Dc Devices, Inc. Prosthesis for reducing intra-cardiac pressure having an embolic filter
US9232997B2 (en) 2006-11-07 2016-01-12 Corvia Medical, Inc. Devices and methods for retrievable intra-atrial implants
US9757107B2 (en) 2009-09-04 2017-09-12 Corvia Medical, Inc. Methods and devices for intra-atrial shunts having adjustable sizes
US7846123B2 (en) 2007-04-24 2010-12-07 Emory University Conduit device and system for implanting a conduit device in a tissue wall
US8376979B2 (en) * 2007-09-25 2013-02-19 The Cleveland Clinic Foundation Method and apparatus of a cardiac fluid flow path
WO2009048949A1 (en) * 2007-10-09 2009-04-16 Wilson-Cook Medical, Inc. Anastomosis plug for bariatric surgery
US7846199B2 (en) * 2007-11-19 2010-12-07 Cook Incorporated Remodelable prosthetic valve
US20090143815A1 (en) * 2007-11-30 2009-06-04 Boston Scientific Scimed, Inc. Apparatus and Method for Sealing a Vessel Puncture Opening
US20090143713A1 (en) 2007-11-30 2009-06-04 Jacques Van Dam Biliary Shunts, Delivery Systems, Methods of Using the Same and Kits Therefor
US8187163B2 (en) 2007-12-10 2012-05-29 Ethicon Endo-Surgery, Inc. Methods for implanting a gastric restriction device
US8100870B2 (en) 2007-12-14 2012-01-24 Ethicon Endo-Surgery, Inc. Adjustable height gastric restriction devices and methods
US8142452B2 (en) 2007-12-27 2012-03-27 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US8377079B2 (en) 2007-12-27 2013-02-19 Ethicon Endo-Surgery, Inc. Constant force mechanisms for regulating restriction devices
US8591395B2 (en) 2008-01-28 2013-11-26 Ethicon Endo-Surgery, Inc. Gastric restriction device data handling devices and methods
US8192350B2 (en) 2008-01-28 2012-06-05 Ethicon Endo-Surgery, Inc. Methods and devices for measuring impedance in a gastric restriction system
US8337389B2 (en) 2008-01-28 2012-12-25 Ethicon Endo-Surgery, Inc. Methods and devices for diagnosing performance of a gastric restriction system
US8221439B2 (en) 2008-02-07 2012-07-17 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using kinetic motion
US7844342B2 (en) 2008-02-07 2010-11-30 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using light
US8114345B2 (en) 2008-02-08 2012-02-14 Ethicon Endo-Surgery, Inc. System and method of sterilizing an implantable medical device
US8591532B2 (en) 2008-02-12 2013-11-26 Ethicon Endo-Sugery, Inc. Automatically adjusting band system
US8057492B2 (en) 2008-02-12 2011-11-15 Ethicon Endo-Surgery, Inc. Automatically adjusting band system with MEMS pump
US8034065B2 (en) 2008-02-26 2011-10-11 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US8187162B2 (en) 2008-03-06 2012-05-29 Ethicon Endo-Surgery, Inc. Reorientation port
US8233995B2 (en) 2008-03-06 2012-07-31 Ethicon Endo-Surgery, Inc. System and method of aligning an implantable antenna
FR2928553B1 (en) * 2008-03-14 2012-03-02 Sophysa Sa Method for regulation of drainage lcr
WO2009117435A2 (en) 2008-03-17 2009-09-24 Northwestern University Devices and methods for percutaneous access, hemostasis, and closure
JP4648472B2 (en) * 2008-08-01 2011-03-09 績 三上 Check valve
US20100131049A1 (en) * 2008-11-24 2010-05-27 Medtronic Vascular, Inc. One-Way valve Prosthesis for Percutaneous Placement Within the Venous System
US9901347B2 (en) 2009-05-29 2018-02-27 Terus Medical, Inc. Biliary shunts, delivery systems, and methods of using the same
WO2011094521A2 (en) 2010-01-29 2011-08-04 Dc Devices, Inc. Devices and methods for reducing venous pressure
US9247942B2 (en) 2010-06-29 2016-02-02 Artventive Medical Group, Inc. Reversible tubal contraceptive device
EP2588042A4 (en) 2010-06-29 2015-03-18 Artventive Medical Group Inc Reducing flow through a tubular structure
US9149277B2 (en) 2010-10-18 2015-10-06 Artventive Medical Group, Inc. Expandable device delivery
JP6130302B2 (en) 2011-01-28 2017-05-17 アピカ カーディオヴァスキュラー リミテッド System for sealing the puncture wound of the tissue wall
EP2670346A2 (en) 2011-02-01 2013-12-11 Georgia Tech Research Corporation Systems for implanting and using a conduit within a tissue wall
EP2675518A1 (en) 2011-02-16 2013-12-25 Sequana Medical AG Apparatus and methods for treating intracorporeal fluid accumulation
JP5575277B2 (en) * 2011-02-18 2014-08-20 株式会社パイオラックスメディカルデバイス Abdominal cavity - venous shunt stent
US9629715B2 (en) 2011-07-28 2017-04-25 V-Wave Ltd. Devices for reducing left atrial pressure having biodegradable constriction, and methods of making and using same
WO2013044267A1 (en) 2011-09-23 2013-03-28 Pulmonx, Inc. Implant loading device and system
WO2013096965A1 (en) 2011-12-22 2013-06-27 Dc Devices, Inc. Methods and devices for intra-atrial devices having selectable flow rates
US9005155B2 (en) 2012-02-03 2015-04-14 Dc Devices, Inc. Devices and methods for treating heart failure
US9649480B2 (en) 2012-07-06 2017-05-16 Corvia Medical, Inc. Devices and methods of treating or ameliorating diastolic heart failure through pulmonary valve intervention
US9414752B2 (en) 2012-11-09 2016-08-16 Elwha Llc Embolism deflector
WO2014117087A1 (en) 2013-01-25 2014-07-31 Apica Cardiovascular Limited Systems and methods for percutaneous access, stabilization and closure of organs
US8984733B2 (en) 2013-02-05 2015-03-24 Artventive Medical Group, Inc. Bodily lumen occlusion
US9095344B2 (en) 2013-02-05 2015-08-04 Artventive Medical Group, Inc. Methods and apparatuses for blood vessel occlusion
US9775636B2 (en) 2013-03-12 2017-10-03 Corvia Medical, Inc. Devices, systems, and methods for treating heart failure
US10149968B2 (en) 2013-06-14 2018-12-11 Artventive Medical Group, Inc. Catheter-assisted tumor treatment
US9737308B2 (en) 2013-06-14 2017-08-22 Artventive Medical Group, Inc. Catheter-assisted tumor treatment
US9636116B2 (en) 2013-06-14 2017-05-02 Artventive Medical Group, Inc. Implantable luminal devices
US9737306B2 (en) 2013-06-14 2017-08-22 Artventive Medical Group, Inc. Implantable luminal devices
WO2019070623A1 (en) * 2017-10-03 2019-04-11 Boston Scientific Scimed, Inc. Flow control stent

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5135467A (en) * 1989-12-07 1992-08-04 Medtronic, Inc. Implantable system and method for coronary perfusions assistance
US5429144A (en) * 1992-10-30 1995-07-04 Wilk; Peter J. Coronary artery by-pass method
US6139517A (en) * 1997-12-15 2000-10-31 Cardeon Corporation Perfusion shunt apparatus and method
US20010034547A1 (en) * 1998-09-10 2001-10-25 Percardia, Inc. Delivery methods for left ventricular conduit
US20050043781A1 (en) * 1998-02-13 2005-02-24 Mark Foley Methods and devices providing transmyocardial blood flow to the arterial vascular system of the heart

Family Cites Families (214)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3926215A (en) 1973-08-03 1975-12-16 Nat Res Dev Fluid control valves
US3671979A (en) 1969-09-23 1972-06-27 Univ Utah Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve
US3858246A (en) 1973-04-19 1975-01-07 Simcha Milo Prosthetic cardiac valves
US3911502A (en) 1974-08-23 1975-10-14 Us Health Composite heart valve poppet
US5876419A (en) 1976-10-02 1999-03-02 Navius Corporation Stent and method for making a stent
US4441215A (en) 1980-11-17 1984-04-10 Kaster Robert L Vascular graft
US4503568A (en) 1981-11-25 1985-03-12 New England Deaconess Hospital Small diameter vascular bypass and method
US4680031A (en) * 1982-11-29 1987-07-14 Tascon Medical Technology Corporation Heart valve prosthesis
US6106538A (en) 1984-05-14 2000-08-22 Shiber; Samuel Method for forming an internal coronary bypass
IT1180531B (en) 1984-09-21 1987-09-23 Ge Sv In Srl bicuspid heart valve prosthesis
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4769029A (en) 1987-06-19 1988-09-06 Patel Jayendrakumar I Prosthetic graft for arterial system repair
US5527337A (en) 1987-06-25 1996-06-18 Duke University Bioabsorbable stent and method of making the same
US6974475B1 (en) 1987-12-08 2005-12-13 Wall W Henry Angioplasty stent
US4979955A (en) 1988-06-06 1990-12-25 Smith Robert M Power assisted prosthetic heart valve
US4995857A (en) 1989-04-07 1991-02-26 Arnold John R Left ventricular assist device and method for temporary and permanent procedures
US6004261A (en) 1989-04-28 1999-12-21 C. R. Bard, Inc. Formed-in-place endovascular stent and delivery system
US4953553A (en) 1989-05-11 1990-09-04 Advanced Cardiovascular Systems, Inc. Pressure monitoring guidewire with a flexible distal portion
US5609626A (en) 1989-05-31 1997-03-11 Baxter International Inc. Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts
EP0474748B1 (en) 1989-05-31 1995-01-25 Baxter International Inc. Biological valvular prosthesis
US5344426A (en) 1990-04-25 1994-09-06 Advanced Cardiovascular Systems, Inc. Method and system for stent delivery
US5411552A (en) 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
DK124690D0 (en) 1990-05-18 1990-05-18 Henning Rud Andersen Klapprotes for implantation in the body for replacement of the natural folding and catheter for use in the implantation of such a prosthesis flap
US5035702A (en) 1990-06-18 1991-07-30 Taheri Syde A Method and apparatus for providing an anastomosis
US5389096A (en) * 1990-12-18 1995-02-14 Advanced Cardiovascular Systems System and method for percutaneous myocardial revascularization
US5397351A (en) * 1991-05-13 1995-03-14 Pavcnik; Dusan Prosthetic valve for percutaneous insertion
US5193546A (en) 1991-05-15 1993-03-16 Alexander Shaknovich Coronary intravascular ultrasound imaging method and apparatus
US5304220A (en) 1991-07-03 1994-04-19 Maginot Thomas J Method and apparatus for implanting a graft prosthesis in the body of a patient
JPH07500023A (en) 1991-07-04 1995-01-05
US6152141A (en) 1994-07-28 2000-11-28 Heartport, Inc. Method for delivery of therapeutic agents to the heart
CA2074304C (en) 1991-08-02 1996-11-26 Cyril J. Schweich, Jr. Drug delivery catheter
CA2087132A1 (en) 1992-01-31 1993-08-01 Michael S. Williams Stent capable of attachment within a body lumen
US5470320A (en) 1992-04-10 1995-11-28 Tiefenbrun; Jonathan Method and related device for obtaining access to a hollow organ
US5758663A (en) 1992-04-10 1998-06-02 Wilk; Peter J. Coronary artery by-pass method
US5385541A (en) 1992-04-24 1995-01-31 Loma Linda University Medical Center Cerebrospinal fluid shunt capable of minimal invasive revision
US5332402A (en) * 1992-05-12 1994-07-26 Teitelbaum George P Percutaneously-inserted cardiac valve
US5258008A (en) 1992-07-29 1993-11-02 Wilk Peter J Surgical stapling device and associated method
US5330486A (en) 1992-07-29 1994-07-19 Wilk Peter J Laparoscopic or endoscopic anastomosis technique and associated instruments
US5287861A (en) 1992-10-30 1994-02-22 Wilk Peter J Coronary artery by-pass method and associated catheter
US5409019A (en) 1992-10-30 1995-04-25 Wilk; Peter J. Coronary artery by-pass method
US5578075B1 (en) 1992-11-04 2000-02-08 Daynke Res Inc Minimally invasive bioactivated endoprosthesis for vessel repair
US5256141A (en) 1992-12-22 1993-10-26 Nelson Gencheff Biological material deployment method and apparatus
US5571215A (en) 1993-02-22 1996-11-05 Heartport, Inc. Devices and methods for intracardiac procedures
US5797960A (en) * 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
WO1994021196A2 (en) 1993-03-18 1994-09-29 C.R. Bard, Inc. Endovascular stents
AU689094B2 (en) 1993-04-22 1998-03-26 C.R. Bard Inc. Non-migrating vascular prosthesis and minimally invasive placement system therefor
US5441515A (en) 1993-04-23 1995-08-15 Advanced Cardiovascular Systems, Inc. Ratcheting stent
US6159565A (en) 1993-08-18 2000-12-12 W. L. Gore & Associates, Inc. Thin-wall intraluminal graft
US5713950A (en) 1993-11-01 1998-02-03 Cox; James L. Method of replacing heart valves using flexible tubes
DE69419877T2 (en) 1993-11-04 1999-12-16 Bard Inc C R Fixed vascular prosthesis
US5443497A (en) 1993-11-22 1995-08-22 The Johns Hopkins University Percutaneous prosthetic by-pass graft and method of use
US5423851A (en) 1994-03-06 1995-06-13 Samuels; Shaun L. W. Method and apparatus for affixing an endoluminal device to the walls of tubular structures within the body
US5487760A (en) 1994-03-08 1996-01-30 Ats Medical, Inc. Heart valve prosthesis incorporating electronic sensing, monitoring and/or pacing circuitry
US5449373A (en) 1994-03-17 1995-09-12 Medinol Ltd. Articulated stent
US6001123A (en) 1994-04-01 1999-12-14 Gore Enterprise Holdings Inc. Folding self-expandable intravascular stent-graft
US5554185A (en) * 1994-07-18 1996-09-10 Block; Peter C. Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same
US5683449A (en) 1995-02-24 1997-11-04 Marcade; Jean Paul Modular bifurcated intraluminal grafts and methods for delivering and assembling same
US5976159A (en) 1995-02-24 1999-11-02 Heartport, Inc. Surgical clips and methods for tissue approximation
DE69518337D1 (en) 1995-03-10 2000-09-14 Impra Inc Endoluminal stent encapsulated and manufacturing
US5591197A (en) 1995-03-14 1997-01-07 Advanced Cardiovascular Systems, Inc. Expandable stent forming projecting barbs and method for deploying
US5571168A (en) * 1995-04-05 1996-11-05 Scimed Lifesystems Inc Pull back stent delivery system
DE19514638C2 (en) * 1995-04-20 1998-06-04 Peter Dr Med Boekstegers An apparatus for venous pressure controlled selective extraction and retroinfusion a fluid from or in veins of the body
DE69629679D1 (en) 1995-06-07 2003-10-02 Edwards Lifesciences Corp Increased vascular implant with an externally supported tape
US6224584B1 (en) * 1997-01-14 2001-05-01 Eclipse Surgical Technologies, Inc. Therapeutic and diagnostic agent delivery
US6010530A (en) 1995-06-07 2000-01-04 Boston Scientific Technology, Inc. Self-expanding endoluminal prosthesis
KR19990064208A (en) 1995-10-13 1999-07-26 트랜스바스큘라, 인코포레이티드 Bypass unit artery occlusion and / or other methods and apparatus for carrying out the blood vessel cross-sectional process
US6283951B1 (en) 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
US6432127B1 (en) 1996-10-11 2002-08-13 Transvascular, Inc. Devices for forming and/or maintaining connections between adjacent anatomical conduits
US6379319B1 (en) 1996-10-11 2002-04-30 Transvascular, Inc. Systems and methods for directing and snaring guidewires
US6375615B1 (en) 1995-10-13 2002-04-23 Transvascular, Inc. Tissue penetrating catheters having integral imaging transducers and their methods of use
US6283983B1 (en) 1995-10-13 2001-09-04 Transvascular, Inc. Percutaneous in-situ coronary bypass method and apparatus
US20020029079A1 (en) 1996-10-11 2002-03-07 Transvascular, Inc. Devices for forming and/or maintaining connections between adjacent anatomical conduits
AT440559T (en) 1995-10-13 2009-09-15 Medtronic Vascular Inc Device for the transvascular interstitial intervened
US6302875B1 (en) 1996-10-11 2001-10-16 Transvascular, Inc. Catheters and related devices for forming passageways between blood vessels or other anatomical structures
US5865723A (en) 1995-12-29 1999-02-02 Ramus Medical Technologies Method and apparatus for forming vascular prostheses
DK0955950T3 (en) 1996-01-04 2006-07-31 Timothy A M Dr Chuter Flat Wire Stent
DE69724605T2 (en) * 1996-01-19 2004-07-08 Scimed Life Systems, Inc., Maple Grove Catheter with a curve with increasing radius
US6033582A (en) 1996-01-22 2000-03-07 Etex Corporation Surface modification of medical implants
US5938682A (en) 1996-01-26 1999-08-17 Cordis Corporation Axially flexible stent
US5980553A (en) 1996-12-20 1999-11-09 Cordis Corporation Axially flexible stent
US6053924A (en) 1996-11-07 2000-04-25 Hussein; Hany Device and method for trans myocardial revascularization
US5810836A (en) 1996-03-04 1998-09-22 Myocardial Stents, Inc. Device and method for trans myocardial revascularization (TMR)
US5971993A (en) 1996-11-07 1999-10-26 Myocardial Stents, Inc. System for delivery of a trans myocardial device to a heart wall
US6258119B1 (en) 1996-11-07 2001-07-10 Myocardial Stents, Inc. Implant device for trans myocardial revascularization
AU2345997A (en) * 1996-04-08 1997-10-29 Medtronic, Inc. Method of fixing a physiologic mitral valve bioprosthesis
US5843163A (en) 1996-06-06 1998-12-01 Wall; William H. Expandable stent having radioactive treatment means
US5662124A (en) 1996-06-19 1997-09-02 Wilk Patent Development Corp. Coronary artery by-pass method
US5797933A (en) 1996-07-16 1998-08-25 Heartport, Inc. Coronary shunt and method of use
US6080170A (en) * 1996-07-26 2000-06-27 Kensey Nash Corporation System and method of use for revascularizing stenotic bypass grafts and other occluded blood vessels
US5755682A (en) 1996-08-13 1998-05-26 Heartstent Corporation Method and apparatus for performing coronary artery bypass surgery
CA2213015A1 (en) 1996-08-23 1998-02-23 Arterial Vascular Engineering, Inc. A profiled stent and method of manufacture
JP2001500401A (en) * 1996-08-26 2001-01-16 トランスバスキュラー インコーポレイテッド Method and apparatus for through the myocardium manner directly cardiac revascularization
US6186972B1 (en) 1996-09-16 2001-02-13 James A. Nelson Methods and apparatus for treating ischemic heart disease by providing transvenous myocardial perfusion
US6447539B1 (en) 1996-09-16 2002-09-10 Transvascular, Inc. Method and apparatus for treating ischemic heart disease by providing transvenous myocardial perfusion
US5655548A (en) * 1996-09-16 1997-08-12 Circulation, Inc. Method for treatment of ischemic heart disease by providing transvenous myocardial perfusion
US6293955B1 (en) 1996-09-20 2001-09-25 Converge Medical, Inc. Percutaneous bypass graft and securing system
US6330884B1 (en) * 1997-11-14 2001-12-18 Transvascular, Inc. Deformable scaffolding multicellular stent
US5968093A (en) 1996-10-28 1999-10-19 Biotronik Mess-And Therapiegerate Gmbh & Co. Stent
US6042581A (en) 1996-11-08 2000-03-28 Thomas J. Fogarty Transvascular TMR device and method
US5941893A (en) 1996-12-02 1999-08-24 Angiotrax, Inc. Apparatus for transluminally performing surgery
US5925074A (en) 1996-12-03 1999-07-20 Atrium Medical Corporation Vascular endoprosthesis and method
US5807384A (en) 1996-12-20 1998-09-15 Eclipse Surgical Technologies, Inc. Transmyocardial revascularization (TMR) enhanced treatment for coronary artery disease
US6067988A (en) 1996-12-26 2000-05-30 Eclipse Surgical Technologies, Inc. Method for creation of drug delivery and/or stimulation pockets in myocardium
US5925012A (en) 1996-12-27 1999-07-20 Eclipse Surgical Technologies, Inc. Laser assisted drug delivery
US5976182A (en) 1997-10-03 1999-11-02 Advanced Cardiovascular Systems, Inc. Balloon-expandable, crush-resistant locking stent and method of loading the same
US5980551A (en) 1997-02-07 1999-11-09 Endovasc Ltd., Inc. Composition and method for making a biodegradable drug delivery stent
US6508825B1 (en) * 1997-02-28 2003-01-21 Lumend, Inc. Apparatus for treating vascular occlusions
US6010449A (en) * 1997-02-28 2000-01-04 Lumend, Inc. Intravascular catheter system for treating a vascular occlusion
US6217549B1 (en) * 1997-02-28 2001-04-17 Lumend, Inc. Methods and apparatus for treating vascular occlusions
US5968064A (en) 1997-02-28 1999-10-19 Lumend, Inc. Catheter system for treating a vascular occlusion
US5938632A (en) 1997-03-06 1999-08-17 Scimed Life Systems, Inc. Radiofrequency transmyocardial revascularization apparatus and method
US6026814A (en) * 1997-03-06 2000-02-22 Scimed Life Systems, Inc. System and method for percutaneous coronary artery bypass
US6035856A (en) * 1997-03-06 2000-03-14 Scimed Life Systems Percutaneous bypass with branching vessel
US6093177A (en) * 1997-03-07 2000-07-25 Cardiogenesis Corporation Catheter with flexible intermediate section
US5851232A (en) 1997-03-15 1998-12-22 Lois; William A. Venous stent
US5876373A (en) * 1997-04-04 1999-03-02 Eclipse Surgical Technologies, Inc. Steerable catheter
WO1998046115A2 (en) 1997-04-11 1998-10-22 Transvascular, Inc. Methods and apparatus for transmyocardial direct coronary revascularization
US5855597A (en) 1997-05-07 1999-01-05 Iowa-India Investments Co. Limited Stent valve and stent graft for percutaneous surgery
US6162245A (en) 1997-05-07 2000-12-19 Iowa-India Investments Company Limited Stent valve and stent graft
US6245102B1 (en) 1997-05-07 2001-06-12 Iowa-India Investments Company Ltd. Stent, stent graft and stent valve
CN1321619C (en) 1997-05-08 2007-06-20 C·R·巴德有限公司 TMT stent and delivery system
DE29708879U1 (en) 1997-05-20 1997-07-31 Jomed Implantate Gmbh coronary stent
US6007575A (en) 1997-06-06 1999-12-28 Samuels; Shaun Laurence Wilkie Inflatable intraluminal stent and method for affixing same within the human body
EP0890346A1 (en) 1997-06-13 1999-01-13 Gary J. Becker Expandable intraluminal endoprosthesis
EP0884029B1 (en) 1997-06-13 2004-12-22 Gary J. Becker Expandable intraluminal endoprosthesis
US6213126B1 (en) * 1997-06-19 2001-04-10 Scimed Life Systems, Inc. Percutaneous artery to artery bypass using heart tissue as a portion of a bypass conduit
US6071292A (en) 1997-06-28 2000-06-06 Transvascular, Inc. Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures
US5935119A (en) 1997-08-06 1999-08-10 United States Surgical Corporation Perfusion structure
IT1293973B1 (en) 1997-08-13 1999-03-15 Sorin Biomedica Cardio Spa Element for the anchorage in situ of implant devices.
US5908029A (en) 1997-08-15 1999-06-01 Heartstent Corporation Coronary artery bypass with reverse flow
US5984965A (en) 1997-08-28 1999-11-16 Urosurge, Inc. Anti-reflux reinforced stent
US5922022A (en) 1997-09-04 1999-07-13 Kensey Nash Corporation Bifurcated connector system for coronary bypass grafts and methods of use
US5984955A (en) 1997-09-11 1999-11-16 Wisselink; Willem System and method for endoluminal grafting of bifurcated or branched vessels
US5976181A (en) 1997-09-22 1999-11-02 Ave Connaught Balloon mounted stent and method therefor
US6520988B1 (en) 1997-09-24 2003-02-18 Medtronic Ave, Inc. Endolumenal prosthesis and method of use in bifurcation regions of body lumens
US5984956A (en) 1997-10-06 1999-11-16 Heartstent Corporation Transmyocardial implant
US6102941A (en) 1997-10-06 2000-08-15 Heartstent Corporation Transmyocardial implant with coronary ingrowth
US5980548A (en) 1997-10-29 1999-11-09 Kensey Nash Corporation Transmyocardial revascularization system
US5989207A (en) 1997-11-03 1999-11-23 Hughes; Boyd R. Double swirl stent
US6045565A (en) 1997-11-04 2000-04-04 Scimed Life Systems, Inc. Percutaneous myocardial revascularization growth factor mediums and method
US6056743A (en) * 1997-11-04 2000-05-02 Scimed Life Systems, Inc. Percutaneous myocardial revascularization device and method
US5961548A (en) 1997-11-18 1999-10-05 Shmulewitz; Ascher Bifurcated two-part graft and methods of implantation
US5976169A (en) 1997-12-16 1999-11-02 Cardiovasc, Inc. Stent with silver coating and method
US6197324B1 (en) * 1997-12-18 2001-03-06 C. R. Bard, Inc. System and methods for local delivery of an agent
US6231546B1 (en) * 1998-01-13 2001-05-15 Lumend, Inc. Methods and apparatus for crossing total occlusions in blood vessels
US6015405A (en) 1998-01-20 2000-01-18 Tricardia, L.L.C. Device for forming holes in tissue
US6250305B1 (en) 1998-01-20 2001-06-26 Heartstent Corporation Method for using a flexible transmyocardial implant
US6214041B1 (en) 1998-01-20 2001-04-10 Heartstent Corporation Transmyocardial implant with septal perfusion
US6200311B1 (en) * 1998-01-20 2001-03-13 Eclipse Surgical Technologies, Inc. Minimally invasive TMR device
US6193734B1 (en) * 1998-01-23 2001-02-27 Heartport, Inc. System for performing vascular anastomoses
US6007576A (en) 1998-02-06 1999-12-28 Mcclellan; Scott B. End to side anastomic implant
US6651670B2 (en) 1998-02-13 2003-11-25 Ventrica, Inc. Delivering a conduit into a heart wall to place a coronary vessel in communication with a heart chamber and removing tissue from the vessel or heart wall to facilitate such communication
US6808498B2 (en) 1998-02-13 2004-10-26 Ventrica, Inc. Placing a guide member into a heart chamber through a coronary vessel and delivering devices for placing the coronary vessel in communication with the heart chamber
CA2320956A1 (en) 1998-02-13 1999-08-19 Mark J. Foley Methods and devices providing transmyocardial blood flow to the arterial vascular system of the heart
US20020144696A1 (en) 1998-02-13 2002-10-10 A. Adam Sharkawy Conduits for use in placing a target vessel in fluid communication with a source of blood
US20010041902A1 (en) 1998-02-13 2001-11-15 Michael J. Lynch Anastomotic methods and devices for placing a target vessel in fluid communication with a source of blood
US6095997A (en) 1998-03-04 2000-08-01 Corvascular, Inc. Intraluminal shunt and methods of use
US5935162A (en) 1998-03-16 1999-08-10 Medtronic, Inc. Wire-tubular hybrid stent
US5980570A (en) 1998-03-27 1999-11-09 Sulzer Carbomedics Inc. System and method for implanting an expandable medical device into a body
DE69940792D1 (en) * 1998-03-31 2009-06-04 Medtronic Vascular Inc Tissue penetrating catheter with transducers for imaging
US5980566A (en) 1998-04-11 1999-11-09 Alt; Eckhard Vascular and endoluminal stents with iridium oxide coating
US6076529A (en) 1998-04-20 2000-06-20 Heartstent Corporation Transmyocardial implant with inserted vessel
US6029672A (en) 1998-04-20 2000-02-29 Heartstent Corporation Transmyocardial implant procedure and tools
DE19819629A1 (en) 1998-05-04 1999-11-11 Jomed Implantate Gmbh Radially expandable stent
US5989287A (en) 1998-05-06 1999-11-23 Av Healing Llc Vascular graft assemblies and methods for implanting same
US6352554B2 (en) 1998-05-08 2002-03-05 Sulzer Vascutek Limited Prosthetic tubular aortic conduit and method for manufacturing the same
US20010027287A1 (en) 1998-05-26 2001-10-04 Trans Vascular, Inc. Apparatus for providing coronary retroperfusion and/or left ventricular assist and methods of use
US6066169A (en) 1998-06-02 2000-05-23 Ave Connaught Expandable stent having articulated connecting rods
US5980533A (en) 1998-06-09 1999-11-09 Scimed Life Systems, Inc. Stent delivery system
US6113823A (en) 1998-06-09 2000-09-05 Heartstent Corporation Pyrolytic carbon transmyocardial implant
WO1999066978A1 (en) 1998-06-22 1999-12-29 Neovasys, Inc. Method, implant and delivery system for enhancing blood flow in tissue
US6036697A (en) * 1998-07-09 2000-03-14 Scimed Life Systems, Inc. Balloon catheter with balloon inflation at distal end of balloon
US6171251B1 (en) * 1998-07-14 2001-01-09 Eclipse Surgical Technologies, Inc. Method and apparatus for optimizing direct vessel implants for myocardial revascularization
US6053942A (en) 1998-08-18 2000-04-25 Heartstent Corporation Transmyocardial implant with coronary stent
US6406488B1 (en) 1998-08-27 2002-06-18 Heartstent Corporation Healing transmyocardial implant
US6139541A (en) 1998-09-02 2000-10-31 Heartstent Corporation Guide for transmyocardial implant
US6196230B1 (en) 1998-09-10 2001-03-06 Percardia, Inc. Stent delivery system and method of use
US6641610B2 (en) 1998-09-10 2003-11-04 Percardia, Inc. Valve designs for left ventricular conduits
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
EP1669042A3 (en) * 1998-09-10 2006-06-28 Percardia, Inc. TMR shunt
US6290728B1 (en) 1998-09-10 2001-09-18 Percardia, Inc. Designs for left ventricular conduit
WO2000015147A1 (en) 1998-09-10 2000-03-23 Percardia, Inc. Transmycardial shunt and its attachment mechanism, for left ventricular revascularization
US6197050B1 (en) 1998-09-14 2001-03-06 Heartstent Corporation Transmyocardial implant with compliance collar
US5997563A (en) 1998-09-28 1999-12-07 Medtronic, Inc. Implantable stent having variable diameter
US6251079B1 (en) * 1998-09-30 2001-06-26 C. R. Bard, Inc. Transthoracic drug delivery device
US6248112B1 (en) 1998-09-30 2001-06-19 C. R. Bard, Inc. Implant delivery system
US6217527B1 (en) * 1998-09-30 2001-04-17 Lumend, Inc. Methods and apparatus for crossing vascular occlusions
US6458092B1 (en) 1998-09-30 2002-10-01 C. R. Bard, Inc. Vascular inducing implants
US6432126B1 (en) 1998-09-30 2002-08-13 C.R. Bard, Inc. Flexible vascular inducing implants
US6363938B2 (en) 1998-12-22 2002-04-02 Angiotrax, Inc. Methods and apparatus for perfusing tissue and/or stimulating revascularization and tissue growth
EP1020166A1 (en) 1999-01-12 2000-07-19 Orbus Medical Technologies, Inc. Expandable intraluminal endoprosthesis
EP1027870B1 (en) 1999-01-12 2005-03-30 Orbus Medical Technologies, Inc. Expandable intraluminal endoprosthesis
US6187034B1 (en) 1999-01-13 2001-02-13 John J. Frantzen Segmented stent for flexible stent delivery system
EP1150610A1 (en) 1999-01-15 2001-11-07 Ventrica Inc. Methods and devices for forming vascular anastomoses
US7025773B2 (en) 1999-01-15 2006-04-11 Medtronic, Inc. Methods and devices for placing a conduit in fluid communication with a target vessel
US6193726B1 (en) 1999-01-15 2001-02-27 Heartstent Corporation Insertion tool for transmyocardial implant
US6110201A (en) 1999-02-18 2000-08-29 Venpro Bifurcated biological pulmonary valved conduit
US6217575B1 (en) * 1999-02-24 2001-04-17 Scimed Life Systems, Inc. PMR catheter
US5976155A (en) 1999-03-05 1999-11-02 Advanced Cardiovascular Systems, Inc. System for removably securing a stent on a catheter assembly and method of use
US20040044392A1 (en) * 1999-05-03 2004-03-04 Jomed Gmbh Stent catheter system
US6409697B2 (en) 1999-05-04 2002-06-25 Heartstent Corporation Transmyocardial implant with forward flow bias
US6406491B1 (en) 1999-05-04 2002-06-18 Heartstent Corporation Compliant transmyocardial implant
US6182668B1 (en) 1999-05-13 2001-02-06 Heartstent Corporation Transmyocardial implant with induced tissue flap
US6126649A (en) 1999-06-10 2000-10-03 Transvascular, Inc. Steerable catheter with external guidewire as catheter tip deflector
US6253768B1 (en) * 1999-08-04 2001-07-03 Percardia, Inc. Vascular graft bypass
US6302892B1 (en) 1999-08-04 2001-10-16 Percardia, Inc. Blood flow conduit delivery system and method of use
US6113630A (en) 1999-08-13 2000-09-05 Heartstent Corporation Transmyocardial implant with minimized coronary insertion
USD438618S1 (en) 1999-08-27 2001-03-06 Jan Otto Solem Graft connector
US6635214B2 (en) * 1999-09-10 2003-10-21 Ventrica, Inc. Manufacturing conduits for use in placing a target vessel in fluid communication with a source of blood
US6854467B2 (en) 2000-05-04 2005-02-15 Percardia, Inc. Methods and devices for delivering a ventricular stent
AT519454T (en) 2000-05-22 2011-08-15 Orbusneich Medical Inc self-expandable stent
US20020032478A1 (en) 2000-08-07 2002-03-14 Percardia, Inc. Myocardial stents and related methods of providing direct blood flow from a heart chamber to a coronary vessel
SE517410C2 (en) 2000-09-20 2002-06-04 Jan Otto Solem The device and the insertion device to provide a complement of blood flow to a coronary artery
US6672932B1 (en) * 2002-01-14 2004-01-06 Treasure Bay, Inc. Actuatable toy containing deformable bladder

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5135467A (en) * 1989-12-07 1992-08-04 Medtronic, Inc. Implantable system and method for coronary perfusions assistance
US5429144A (en) * 1992-10-30 1995-07-04 Wilk; Peter J. Coronary artery by-pass method
US6139517A (en) * 1997-12-15 2000-10-31 Cardeon Corporation Perfusion shunt apparatus and method
US20050043781A1 (en) * 1998-02-13 2005-02-24 Mark Foley Methods and devices providing transmyocardial blood flow to the arterial vascular system of the heart
US20010034547A1 (en) * 1998-09-10 2001-10-25 Percardia, Inc. Delivery methods for left ventricular conduit

Cited By (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776053B2 (en) 2000-10-26 2010-08-17 Boston Scientific Scimed, Inc. Implantable valve system
US9943670B2 (en) 2001-04-20 2018-04-17 V-Wave Ltd. Methods and apparatus for reducing localized circulatory system pressure
US10207087B2 (en) 2001-04-20 2019-02-19 HemoDynamx Technologies, Ltd. Methods and apparatus for reducing localized circulatory system pressure
US9724499B2 (en) 2001-04-20 2017-08-08 V-Wave Ltd. Device and method for controlling in-vivo pressure
US7682385B2 (en) 2002-04-03 2010-03-23 Boston Scientific Corporation Artificial valve
US20060253189A1 (en) * 2002-04-03 2006-11-09 Boston Scientific Corporation Artificial valve
US7780627B2 (en) 2002-12-30 2010-08-24 Boston Scientific Scimed, Inc. Valve treatment catheter and methods
US9301843B2 (en) 2003-12-19 2016-04-05 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US8721717B2 (en) 2003-12-19 2014-05-13 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US8128681B2 (en) 2003-12-19 2012-03-06 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US7854761B2 (en) 2003-12-19 2010-12-21 Boston Scientific Scimed, Inc. Methods for venous valve replacement with a catheter
US8002824B2 (en) 2004-09-02 2011-08-23 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US8932349B2 (en) 2004-09-02 2015-01-13 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US9918834B2 (en) 2004-09-02 2018-03-20 Boston Scientific Scimed, Inc. Cardiac valve, system and method
US20100256776A1 (en) * 2005-01-19 2010-10-07 Gi Dynamics, Inc. Eversion Resistant Sleeves
US8096966B2 (en) * 2005-01-19 2012-01-17 Gi Dynamics, Inc. Eversion resistant sleeves
US7854755B2 (en) 2005-02-01 2010-12-21 Boston Scientific Scimed, Inc. Vascular catheter, system, and method
US9622859B2 (en) 2005-02-01 2017-04-18 Boston Scientific Scimed, Inc. Filter system and method
US7780722B2 (en) 2005-02-07 2010-08-24 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US7670368B2 (en) 2005-02-07 2010-03-02 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US9808341B2 (en) 2005-02-23 2017-11-07 Boston Scientific Scimed Inc. Valve apparatus, system and method
US7867274B2 (en) 2005-02-23 2011-01-11 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US9370419B2 (en) 2005-02-23 2016-06-21 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US9861473B2 (en) 2005-04-15 2018-01-09 Boston Scientific Scimed Inc. Valve apparatus, system and method
US7722666B2 (en) 2005-04-15 2010-05-25 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US8512399B2 (en) 2005-04-15 2013-08-20 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US9028542B2 (en) 2005-06-10 2015-05-12 Boston Scientific Scimed, Inc. Venous valve, system, and method
US8012198B2 (en) 2005-06-10 2011-09-06 Boston Scientific Scimed, Inc. Venous valve, system, and method
US8460365B2 (en) 2005-09-21 2013-06-11 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US8672997B2 (en) 2005-09-21 2014-03-18 Boston Scientific Scimed, Inc. Valve with sinus
US7951189B2 (en) 2005-09-21 2011-05-31 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US9474609B2 (en) 2005-09-21 2016-10-25 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US7799038B2 (en) 2006-01-20 2010-09-21 Boston Scientific Scimed, Inc. Translumenal apparatus, system, and method
US9681948B2 (en) 2006-01-23 2017-06-20 V-Wave Ltd. Heart anchor device
US20090198315A1 (en) * 2006-04-28 2009-08-06 Younes Boudjemline Vascular Stents, Methods of Use and Methods of Manufacture
US20080126131A1 (en) * 2006-07-17 2008-05-29 Walgreen Co. Predictive Modeling And Risk Stratification Of A Medication Therapy Regimen
US8348999B2 (en) 2007-01-08 2013-01-08 California Institute Of Technology In-situ formation of a valve
US8133270B2 (en) 2007-01-08 2012-03-13 California Institute Of Technology In-situ formation of a valve
US8470023B2 (en) 2007-02-05 2013-06-25 Boston Scientific Scimed, Inc. Percutaneous valve, system, and method
US9421083B2 (en) 2007-02-05 2016-08-23 Boston Scientific Scimed Inc. Percutaneous valve, system and method
US10226344B2 (en) 2007-02-05 2019-03-12 Boston Scientific Scimed, Inc. Percutaneous valve, system and method
US7967853B2 (en) 2007-02-05 2011-06-28 Boston Scientific Scimed, Inc. Percutaneous valve, system and method
US8828079B2 (en) 2007-07-26 2014-09-09 Boston Scientific Scimed, Inc. Circulatory valve, system and method
US8414641B2 (en) 2007-12-21 2013-04-09 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
US8137394B2 (en) 2007-12-21 2012-03-20 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
US7892276B2 (en) 2007-12-21 2011-02-22 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
US9707382B2 (en) 2009-05-04 2017-07-18 V-Wave Ltd. Device and method for regulating pressure in a heart chamber
US9980815B2 (en) 2009-05-04 2018-05-29 V-Wave Ltd. Devices for reducing left atrial pressure, and methods of making and using same
US10076403B1 (en) 2009-05-04 2018-09-18 V-Wave Ltd. Shunt for redistributing atrial blood volume
US10251740B2 (en) 2009-05-04 2019-04-09 V-Wave Ltd. Shunt for redistributing atrial blood volume
US9668859B2 (en) 2011-08-05 2017-06-06 California Institute Of Technology Percutaneous heart valve delivery systems
US9744037B2 (en) 2013-03-15 2017-08-29 California Institute Of Technology Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves
US9713696B2 (en) 2013-05-21 2017-07-25 V-Wave Ltd. Apparatus and methods for delivering devices for reducing left atrial pressure
WO2018022862A1 (en) * 2016-07-27 2018-02-01 Sainath Intellectual Properties, Llc Stent with one-way sock valve
WO2018035151A1 (en) * 2016-08-15 2018-02-22 The Trustees Of Columbia University In The City Of New York Conduit to increase coronary blood flow
WO2018071373A1 (en) * 2016-10-10 2018-04-19 Kassab Ghassan S Devices and methods for treating congestive heart failure, ascites, and other disorders relating to excess bodily fluid

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US6641610B2 (en) 2003-11-04
US20020165606A1 (en) 2002-11-07
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EP1112044A1 (en) 2001-07-04
WO2000015149A1 (en) 2000-03-23

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