US20060105376A1 - Novel full-length cDNA - Google Patents

Novel full-length cDNA Download PDF

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US20060105376A1
US20060105376A1 US11/293,697 US29369705A US2006105376A1 US 20060105376 A1 US20060105376 A1 US 20060105376A1 US 29369705 A US29369705 A US 29369705A US 2006105376 A1 US2006105376 A1 US 2006105376A1
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polynucleotide
protein
polypeptide
nucleotide sequence
seq
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US11/293,697
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Takao Isogai
Tomoyasu Sugiyama
Tetsuji Otsuki
Ai Wakamatsu
Hiroyuki Sato
Shizuko Ishii
Jun-Ichi Yamamoto
Yuuko Isono
Yuri Hio
Kaoru Otsuka
Keiichi Nagai
Ryotaro Irie
Ichiro Tamechika
Naohiko Seki
Tsutomu Yoshikawa
Motoyuki Otsuka
Kenji Nagahari
Yasuhiko Masuho
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Research Association for Biotechnology
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Research Association for Biotechnology
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Priority to US11/293,697 priority Critical patent/US20060105376A1/en
Publication of US20060105376A1 publication Critical patent/US20060105376A1/en
Priority to US11/767,852 priority patent/US7560541B2/en
Priority to US12/502,157 priority patent/US20090311748A1/en
Abandoned legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Definitions

  • the present invention relates to polynucleotides encoding novel polypeptides, polypeptides encoded by the polynucleotides, and new uses of these.
  • the aim of the determination of genomic sequence is to reveal the functions of all genes and their regulation and to understand living organisms as a network of interactions between genes, proteins, cells or individuals through deducing the information in a genome, which is a blueprint of the highly complicated living organisms.
  • To understand living organisms by utilizing the genomic information from various species is not only important as an academic subject, but also socially significant from the viewpoint of industrial application.
  • genomic sequences itself cannot identify the functions of all genes. For example, as for yeast, only the function of approximately half of the 6000 genes, which is predicted based on the genomic sequence, was able to be deduced. On the other hand, the human genome has been estimated to contain about 30,000-40,000 genes. Further, 100,000 or more types of mRNAs are said to exist when variants produced by alternative splicing are taken into consideration. Therefore, it is desirable to establish “a high throughput analysis system of the gene functions” which allows us to identify rapidly and efficiently the functions of vast amounts of the genes obtained by the genomic sequencing.
  • cDNA which is produced from mRNA that lacks introns, encodes a protein as a single continuous amino acid sequence and allows us to identify the primary structure of the protein easily.
  • ESTs Expression Sequence Tags
  • ESTs The information of ESTs is utilized for analyzing the structure of human genome, or for predicting the exon-regions of genomic sequences or their expression profile.
  • many human ESTs have been derived from proximal regions to the 3′-end of cDNA, and information around the 5′-end of mRNA is extremely little.
  • human cDNAs the number of the corresponding mRNAs whose encoding full-length protein sequences are deduced is approximately 13,000.
  • a novel human full-length cDNA is isolated, it can be used for developing medicines for diseases in which the gene is involved.
  • the protein encoded by the gene can be used as a drug by itself. Thus, it has great significance to obtain a full-length cDNA encoding a novel human protein.
  • human secretory proteins or membrane proteins would be useful by itself as a medicine like tissue plasminogen activator (TPA), or as a target of medicines like membrane receptors.
  • TPA tissue plasminogen activator
  • genes for signal transduction-related proteins (protein kinases, etc.), glycoprotein-related proteins, transcription-related proteins, etc. are genes whose relationships to human diseases have been elucidated.
  • genes for disease-related proteins form a gene group rich in genes whose relationships to human diseases have been elucidated.
  • An objective of the present invention is to provide polynucleotides encoding novel polypeptides, polypeptides encoded by the polynucleotides, and novel usages of these.
  • the inventors have developed a method for efficiently cloning, from a cDNA library having very high fullness-ratio, a human full-length cDNA that is predicted to be a full-length cDNA clone, where the cDNA library is synthesized by an improved method (WO 01/04286) of the oligo-capping method (K. Maruyama and S. Sugano, Gene, 138: 171-174 (1994); Y. Suzuki et al., Gene, 200: 149-156 (1997)). Then, the nucleotide sequences of cDNA clones whose fullness ratio is high, obtained by this method, were determined mainly from their 5′-ends, and, if required, from 3′-ends.
  • nr a protein database, which has been constructed by combining data of coding sequences (CDS) in nucleotide sequences deposited in GenBank, and data of SwissProt, PDB (http://www.rcsb.org/pdb/index.html), PIR (http://pir.georgetown.edu/pirwww/pirhome.shtml), and PRF (http://www.prf.or.jp/en/); overlapping sequences have been removed.)
  • CDS coding sequences
  • the gene expression profiles of cDNA clones whose full-length nucleotide sequence had been determined were studied by analyzing the large-scale cDNA database constructed based on the 5′-end nucleotide sequences of cDNAs obtained.
  • the profiles of gene expression in living cells were also determined by PCR. The present inventors revealed the usefulness of the genes of the present invention based on these analysis results.
  • gene functions were revealed by the analysis of expression profiles in silico based on the information of full-length nucleotide sequences.
  • the expression profiles used in the expression frequency analysis were studied based on the database containing sufficient amount of fragment sequence data.
  • the expression frequency analysis was carried out by referring, for these expression profiles, to the full-length nucleotide sequences of many cDNA clones obtained in the present invention.
  • a highly reliable analysis can be achieved by referring to the full-length nucleotide sequences of a wide variety of genes for the sufficiently large population for analysis (expression profiles).
  • the results of expression frequency analysis using the full-length sequences of the present invention more precisely reflect the gene expression frequency in tissues and cells from which a certain cDNA library was derived.
  • the information of full-length cDNA nucleotide sequence of the present invention made it possible to achieve the highly reliable expression frequency analysis.
  • the full-length cDNA clones of this invention were obtained by the method comprising the steps of [1] preparing libraries containing cDNAs with the high fullness ratio by oligo-capping, and [2] assembling 5′-end sequences and selecting one with the highest probability of completeness in length in the cluster formed (there are many clones longer in the 5′-end direction).
  • the uses of primers designed based on the 5′- and 3′-end sequences of polynucleotides provided by the present invention enable readily obtaining full-length cDNAs without such a special technique.
  • the primer which is designed to be used for obtaining cDNAs capable of being expressed, is not limited to the 5′- and 3′-end sequences of polynucleotide.
  • the present invention relates to a polynucleotide selected from the group consisting of the following (a) to (g):
  • a polynucleotide comprising a nucleotide sequence encoding a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs shown in Table 1, wherein, in said amino acid sequence, one or more amino acids have been substituted, deleted, inserted, and/or added, and wherein said nucleotide sequence encodes a polypeptide functionally equivalent to a polypeptide comprising the selected amino acid sequence;
  • polynucleotide comprising a′ nucleotide sequence encoding a partial amino acid sequence of a polypeptide encoded by the polynucleotide according to any one of (a) to (d);
  • a polynucleotide comprising a nucleotide sequence having at least 90% identity to the nucleotide sequence of (a).
  • the present invention also relates to a polypeptide encoded by the above-mentioned polynucleotide or a partial peptide thereof, an antibody binding to the polypeptide or the peptide, and a method for immunologically assaying the polypeptide or the peptide, which comprises the steps of contacting the polypeptide or the peptide with the antibody, and observing the binding between the two.
  • the present invention features a vector comprising the above-mentioned polynucleotide, a transformant carrying the polynucleotide or the vector, a transformant carrying the polynucleotide or the vector in an expressible manner, and a method for producing the polypeptide or the peptide, which comprises the steps of culturing the transformant and recovering an expression product.
  • Another feature of the present invention is an oligonucleotide comprising at least 15 nucleotides, said oligonucleotide comprising a nucleotide sequence complementary to the nucleotide sequence of any one of SEQ ID NOs: 1 to 2443 or to a complementary strand thereof.
  • This oligonucleotide can be used as a primer for synthesizing the above-mentioned polynucleotide or used as a probe for detecting the polynucleotide.
  • the present invention includes an antisense polynucleotide against the polynucleotide or a part thereof, and a method for detecting the polynucleotide, which comprises the following steps of:
  • Still another feature of the present invention is database of polynucleotides and/or polypeptides, said database comprising information on at least one of the nucleotide sequences of SEQ ID NOs: 1 to 2443 and/or on at least one of the amino acid sequences of SEQ ID NOs: 2444 to 4886.
  • polynucleotide is defined as a molecule, such as DNA and RNA, in which multiple nucleotides are polymerized. There are no limitations on the number of the polymerized nucleotides. In case that the polymer contains relatively low number of nucleotides, it is also described as an “oligonucleotide”, which is included in the “polynucleotide” of the present invention.
  • the polynucleotide or the oligonucleotide of the present invention can be a natural or chemically synthesized product. Alternatively, it can be synthesized using a template polynucleotide by an enzymatic reaction such as PCR.
  • the polynucleotide of the present invention may be modified chemically. Moreover, not only a single-strand polynucleotide but also a double-strand polynucleotide is included in the present invention.
  • polynucleotide when the polynucleotide is described merely as “polynucleotide”, it means not only a single-strand polynucleotide but also a double-strand polynucleotide.
  • the nucleotide sequence of only one chain is indicated. However, based on the nucleotide sequence of a sense chain, the nucleotide sequence of the complementary strand thereof is essentially determined.
  • an “isolated polynucleotide” is a polynucleotide the structure of which is not identical to that of any naturally occurring polynucleotide or to that of any fragment of a naturally occurring genomic polynucleotide spanning more than three separate genes.
  • the term therefore includes, for example, (a) a DNA which has the sequence of part of a naturally occurring genomic DNA molecule in the genome of the organism in which it naturally occurs; (b) a polynucleotide incorporated into a vector or into the genomic DNA of a prokaryote or eukaryote in a manner such that the resulting molecule is not identical to any naturally occurring vector or genomic DNA; (c) a separate molecule such as a cDNA, a genomic fragment, a fragment produced by polymerase chain reaction (PCR), or a restriction fragment; and (d) a recombinant nucleotide sequence that is part of a hybrid gene, i.e., a gene encoding a fusion polypeptide.
  • substantially pure protein or polypeptide as used herein in reference to a given protein or polypeptide means that the protein or polypeptide is substantially free from other biological macromolecules.
  • the substantially pure protein or polypeptide is at least 75%, 80%, 85%, 95%, or 99% pure by dry weight. Purity can be measured by any appropriate standard method known in the art, for example, by column chromatography, polyacrylamide gel electrophoresis, or HPLC analysis.
  • All the cDNAs provided by the present invention are full-length cDNAs.
  • the “full-length cDNA” herein means that the cDNA contains the ATG codon, which is the start point of translation therein.
  • the untranslated regions upstream and downstream of the protein-coding region, both of which are naturally contained in natural mRNAs, are not indispensable. It is preferable that the full-length cDNAs of the present invention contain the stop codon.
  • FIG. 1 shows the restriction map of the vector pME18SFL3.
  • All the clones (2443 clones) of the present invention are novel and encode the full-length polypeptides. Further, all the clones are cDNAs with the high fullness ratio, which were obtained by oligo-capping method, and also clones which are not identical to any of known human mRNAs (namely, novel clones) selected by searching, for the 5′-end sequences, mRNA sequences with the annotation of “complete cds” in the GenBank and UniGene databases by using the BLAST homology search [S. F. Altschul, W. Gish, W. Miller, E. W. Myers & D. J. Lipman, J. Mol. Biol., 215: 403-410 (1990); W. Gish & D.
  • All the full-length cDNAs of the present invention can be synthesized by a method such as PCR (Current protocols in Molecular Biology edit. Ausubel et al. (1987) Publish. John Wiley & Sons Section 6.1-6.4) using primer sets designed based on the 5′-end and 3′-end sequences or using primer sets of primers designed based on the 5′-end sequences and a primer of oligo dT sequence corresponding to poly A sequence.
  • PCR Current protocols in Molecular Biology edit. Ausubel et al. (1987) Publish. John Wiley & Sons Section 6.1-6.4
  • primer sets designed based on the 5′-end and 3′-end sequences or using primer sets of primers designed based on the 5′-end sequences and a primer of oligo dT sequence corresponding to poly A sequence.
  • Table 1 contains the clone names of full-length cDNA of 2443 clones of the present invention, SEQ ID NOs of the full-length nucleotide sequences, CDS portions deduced from the full-length nucleotide sequences, and SEQ ID NOs of the translated amino acids.
  • the positions of CDS are shown according to the rule of “DDBJ/EMBL/GenBank Feature Table Definition” (http://www.ncbi.nlm.nih.gov/collab/FT/index.html).
  • the start position number corresponds to the first letter of “ATG” that is the nucleotide triplet encoding methionine; the termination position number corresponds to the third letter of the stop codon.
  • primers used to synthesize polynucleotides can be designed based on the nucleotide sequences of polynucleotides of the present invention shown in SEQ ID NOs in the above Table 1.
  • an oligo dT primer can be used as the 3′-end primer.
  • the length of the primers is usually 15-100 bp, and favorably between 15-35 bp. In case of LA PCR, which is described below, the primer length of 25-35 bp may provide a good result.
  • a method to design a primer that enables a specific amplification based on the aimed nucleotide sequence is known to those skilled in the art (Current Protocols in Molecular Biology, Ausubel et al. edit, (1987) John Wiley & Sons, Section 6.1-6.4).
  • the primer is designed so as that, in principle, the amplification products will include the translation start site. Accordingly, for example, when the 5′-end primer is designed based on the nucleotide sequence of 5′ untranslated region (5′UTR), any part of the 5′-end, which ensures the specificity to the cDNA of interest, can be selected as the primer.
  • the target nucleotide sequence to be amplified can extend to several thousand bp in some cDNA.
  • LA PCR Long and Accurate PCR
  • LA PCR in which a special DNA polymerase having 3′->5′ exonuclease activity is used, misincorporated nucleotides can be removed. Accordingly, accurate synthesis of the complementary strand can be achieved even with a long nucleotide sequence.
  • a template DNA for synthesizing the full-length cDNA of the present invention can be obtained by using cDNA libraries that are prepared by various methods.
  • the full-length cDNA clones of the present invention are clones with high probability of completeness in length, which were obtained by the method comprising the steps of [1] preparing libraries containing cDNAs with the very high fullness ratio by oligo-capping, and [2] assembling the 5′-end sequences and selecting one with the highest probability of completeness in length in the cluster formed (there are many clones longer in the 5′-end direction).
  • primers designed based on the full-length nucleotide sequences provided by the present invention enable easily obtaining full-length cDNAs without such a special technique.
  • the problem with the cDNA libraries prepared by the known methods or commercially available is that mRNA contained in the libraries has very low fullness ratio. Thus, it is difficult to screen full-length cDNA clone directly from the library using ordinary cloning methods.
  • the present invention has revealed a nucleotide sequence of novel full-length cDNA. If a full-length nucleotide sequence is provided, it is possible to synthesize a target full-length cDNA by using enzymatic reactions such as PCR. In particular, a full-length-enriched cDNA library, synthesized by methods such as oligo-capping, is desirable to synthesize a full-length cDNA with more reliability.
  • the 5′-end sequence of the full-length cDNA clones of the invention can be used to isolate the regulatory element of transcription including the promoter on the genome.
  • a rough draft of the human genome analysis of human genomic sequence with lower accuracy
  • analysis of the entire human genomic sequence is going to be finished.
  • the polypeptide encoded by the full-length cDNA of the invention can be prepared as a recombinant polypeptide or as a natural polypeptide.
  • the recombinant polypeptide can be prepared by inserting the polynucleotide encoding the polypeptide of the invention into a vector, introducing the vector into an appropriate host cell and purifying the polypeptide expressed within the transformed host cell, as described below.
  • the natural polypeptide can be prepared, for example, by utilizing an affinity column to which an antibody against the polypeptide of the invention (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 16.1-16.19) is attached.
  • the antibody used for affinity purification may be either a polyclonal antibody, or a monoclonal antibody.
  • in vitro translation See, for example, “On the fidelity of mRNA translation in the nuclease-treated rabbit reticulocyte lysate system.” Dasso M. C., and Jackson R. J. (1989) Nucleic Acids Res. 17: 3129-3144) may be used for preparing the polypeptide of the invention.
  • Polypeptides functionally equivalent to the polypeptides of the present invention can be prepared based on the activities, which were clarified in the above-mentioned manner, of the polypeptides of the present invention. Using the biological activity possessed by the polypeptide of the invention as an index, it is possible to verify whether or not a particular polypeptide is functionally equivalent to the polypeptide of the invention by examining whether or not the polypeptide has said activity.
  • Polypeptides functionally equivalent to the polypeptides of the present invention can be prepared by those skilled in the art, for example, by using a method for introducing mutations into an amino acid sequence of a polypeptide (for example, site-directed mutagenesis (Current Protocols in Molecular Biology, edit, Ausubel et al., (1987) John Wiley & Sons, Section 8.1-8.5) Besides, such polypeptides can be generated by spontaneous mutations.
  • the present invention also includes a polypeptide comprising the amino acid sequence shown in Table 1 in which one or more amino acids are substituted, deleted, inserted, and/or added, as long as the polypeptides have the equivalent functions to those of the polypeptides identified in the present Examples described later.
  • substitution of one or more amino acids includes substitution of several amino acids.
  • severeal amino acids means, for example, 5 amino acids, preferably 4 or 3 amino acids, more preferably 2 amino acids, and further preferably 1 amino acid.
  • a substituted amino acid has a similar property to that of the original amino acid.
  • Ala, Val, Leu, Ile, Pro, Met, Phe and Trp are assumed to have similar properties to one another because they are all classified into a group of non-polar amino acids.
  • substitution can be performed among non-charged amino acid such as Gly, Ser, Thr, Cys, Tyr, Asn, and Gln, acidic amino acids such as Asp and Glu, and basic amino acids such as Lys, Arg, and His.
  • polypeptides functionally equivalent to the polypeptides of the present invention can be isolated by using techniques of hybridization or gene amplification known to those skilled in the art. Specifically, using the hybridization technique (Current Protocols in Molecular Biology, edit, Ausubel et al., (1987) John Wiley & Sons, Section 6.3-6.4)), those skilled in the art can usually isolate a polynucleotide highly homologous to the polynucleotide encoding the polypeptide identified in the present Example based on the identified nucleotide sequence (Table 1) or a portion thereof and obtain the functionally equivalent polypeptide from the isolated polynucleotide.
  • the present invention include polypeptides encoded by the polynucleotides hybridizing with the polynucleotides encoding the polypeptides identified in the present Example, as long as the polypeptides are functionally equivalent to the polypeptides identified in the present Example.
  • Organisms from which the functionally equivalent polypeptides are isolated are illustrated by vertebrates such as human, mouse, rat, rabbit, pig and bovine, but are not limited to these animals.
  • Washing conditions of hybridization for the isolation of polynucleotides encoding the functionally equivalent polypeptides are usually “1 ⁇ SSC, 0.1% SDS, 37° C.”; more stringent conditions are “0.5 ⁇ SSC, 0.1% SDS, 42° C.”; and still more stringent conditions are “0.1 ⁇ SSC, 0.1% SDS, 65° C.”.
  • the following conditions can be given as hybridization conditions of the present invention. Namely, conditions in which the hybridization is done at “6 ⁇ SSC, 40% Formamide, 25° C.”, and the washing at “1 ⁇ SSC, 55° C.” can be given.
  • More preferable conditions are those in which the hybridization is done at “6 ⁇ SSC, 40% Formamide, 37° C.”, and the washing at “0.2 ⁇ SSC, 55° C.”. Even more preferable are those in which the hybridization is done at “6 ⁇ SSC, 50% Formamide, 37° C.”, and the washing at “0.1 ⁇ SSC, 62° C.”.
  • the more stringent the conditions of hybridization are the more frequently the polynucleotides highly homologous to the probe sequence are isolated. Therefore, it is preferable to conduct hybridization under stringent conditions.
  • stringent conditions in the present invention are, washing conditions of “0.5 ⁇ SSC, 0.1% SDS, 42° C.”, or alternatively, hybridization conditions of “6 ⁇ SSC, 40% Formamide, 37° C.”, and the washing at “0.2 ⁇ SSC, 55° C.”.
  • One skilled in the art can suitably select various conditions, such as dilution ratios of SSC, formamide concentrations, and temperatures to accomplish a similar stringency.
  • the amino acid sequences of polypeptides isolated by using the hybridization techniques usually have high identity to those of the polypeptides of the present invention, which are shown in Table 1.
  • the present invention encompasses a polynucleotide comprising a nucleotide sequence that has a high identity to the nucleotide sequence of claim 1 (a).
  • the present invention encompasses a peptide, or polypeptide comprising an amino acid sequence that has a high identity to the amino acid sequence encoded by the polynucleotide of claim 1 (b).
  • the term “high identity” indicates sequence identity of at least 40% or more; preferably 60% or more; and more preferably 70% or more. Alternatively, more preferable is identity of 90% or more, or 93% or more, or 95% or more, furthermore, 97% or more, or 99% or more.
  • the identity can be determined by using the BLAST search algorithm.
  • the present invention also provides a polynucleotide containing at least 15 nucleotides complementary to a polynucleotide comprising a nucleotide sequence of SEQ ID NOs shown in Table 1 or the complementary strand thereof.
  • complementary strand is defined as one strand of a double strand DNA composed of A:T and G:C base pair to the other strand.
  • complementary is defined as not only those completely matching within a continuous region of at least 15 nucleotides, but also having a identity of at least 70%, favorably 80% or higher, more favorably 90% or higher, and most favorably 95% or higher within that region. The identity may be determined using the algorithm described herein.
  • Such a polynucleotide includes probes and primers used for the detection and amplification of a polynucleotide encoding the inventive polypeptide.
  • the polynucleotide When used as a primer, the polynucleotide usually comprises 15 to 100 bp, and preferably of 15 to 35 bp.
  • the polynucleotide When used as a probe, the polynucleotide comprises the whole or a part of the sequence of a polynucleotide of the invention, and comprises at least 15 bp.
  • primers such polynucleotides are complementary at the 3′-end, and restriction enzyme recognition sequences or tags can be added to the 5′-end.
  • polynucleotides of the present invention include an antisense polynucleotide for suppressing the expression of a polypeptide of the invention, which comprises an amino acid sequence of SEQ ID NOs shown in Table 1.
  • an antisense polynucleotide has at least 15 bp or more, for example 50 bp or more, preferably 100 bp or more, and more preferably 500 bp or more, and usually has 3000 bp or less, and preferably 2000 bp or less.
  • Antisense polynucleotides can be used in the gene therapy of diseases caused by abnormalities of the polypeptides of the invention (abnormal function or abnormal expression).
  • An antisense polynucleotide can be prepared, for example, by the phosphorothioate method (“Physicochemical properties of phosphorothioate oligodeoxynucleotides.” Stein (1988) Nucleic Acids Res. 16: 3209-3221) based on the sequence information of polynucleotide encoding a polypeptide of the invention (for example, the nucleotide sequences of SEQ ID NO: 1 to 2443).
  • the polynucleotides or antisense polynucleotides of the present invention can be used in, for example, gene therapy.
  • target diseases for example, cancers or various inflammatory diseases may be preferable.
  • These molecules can be used for gene therapy, for example, by administrating them to patients by the in vivo or ex vivo method using virus vectors such as retrovirus vectors, adenovirus vectors, and adeno-related virus vectors, or non-virus vectors such as liposomes.
  • the present invention also includes a partial peptide of the polypeptides of the invention.
  • the partial peptide comprises a polypeptide generated as a result that a signal peptide has been removed from a secretory protein. If the polypeptide of the present invention has an activity as a receptor or a ligand, the partial peptide may function as a competitive inhibitor of the polypeptide and may bind to the receptor (or ligand).
  • the present invention includes an antigen peptide for raising antibodies.
  • the peptides comprise at least 7 amino acids, preferably 8 amino acids or more, more preferably 9 amino acids or more, and even more preferably 10 amino acids or more.
  • the peptide can be used for preparing antibodies against the polypeptide of the invention, or competitive inhibitors of them, and also screening for a receptor that binds to the polypeptide of the invention.
  • the partial peptides of the invention can be produced, for example, by genetic engineering methods, known methods for synthesizing peptides, or digesting the polypeptide of the invention with an appropriate peptidase.
  • the present invention also relates to a vector into which a polynucleotide of the invention is inserted.
  • the vector of the invention is not limited as long as it contains the inserted polynucleotide stably.
  • vectors such as pBluescript vector (Stratagene) are preferable as a cloning vector.
  • expression vectors are especially useful. Any expression vector can be used as long as it is capable of expressing the polypeptide in vitro, in E. coli , in cultured cells, or in vivo.
  • PBEST vector Promega
  • pET vector Invitrogen
  • ligation utilizing restriction sites can be performed according to the standard method (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.4-11.11).
  • GATEWAYTM is an expression vector construction system for polypeptide expression
  • This system includes two types of site-specific recombinases (BP CLONASETM and LR CLONASETM) derived from lambda phage and uses BP CLONASETM-specific recombination sites for an Entry Vector and LR CLONASETM-specific recombination sites for a Destination Vector, which may comprise a tag useful for polypeptide purification.
  • BP CLONASETM and LR CLONASETM site-specific recombinases
  • a polynucleotide fragment of interest is inserted into the entry vector using the first recombination. Then, the secondary recombination is allowed to take place between the entry vector, where the polynucleotide fragment of interest has been inserted, and the destination vector.
  • the expression vector can be prepared rapidly and highly efficiently.
  • the step of expression vector construction and expression of polypeptide of interest takes about 7 to 10 days.
  • the polypeptide of interest can be expressed and prepared in only 3 to 4 days. Thus, the system ensures a high-throughput functional analysis for expressed polypeptides (http://biotech.nikkeibp.co.jp/netlink/lto/gateway/).
  • the present invention also relates to a transformant carrying the vector of the invention.
  • Any cell can be used as a host into which the vector of the invention is inserted, and various kinds of host cells can be used depending on the purposes.
  • COS cells or CHO cells can be used, for example.
  • Introduction of the vector into host cells can be performed, for example, by calcium phosphate precipitation method, electroporation method (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 9.1-9.9), lipofectamine method (GIBCO-BRL), or microinjection method, etc.
  • a polynucleotide containing at least 15 nucleotides comprising a nucleotide sequence of any one of the polynucleotides comprising the nucleotide sequences of SEQ ID NOs shown in Table 1 or the complementary strand thereof can be used not only as a primer for synthesizing full-length cDNAs but also for testing and diagnosing the abnormalities of the polypeptide encoded by the full-length cDNA of the present invention.
  • polymerase chain reaction genomic DNA-PCR, or RT-PCR
  • the obtained genomic region can be used for detection and/or diagnosis of the abnormality of the sequence by RFLP analysis, SSCP, or sequencing.
  • analysis of the amount of expression of the mRNA using the polynucleotide of the present invention as a probe or a primer enables detection and diagnosis of the disease.
  • the present invention also relates to antibodies that bind to the polypeptide of the invention.
  • antibodies that bind to the polypeptide of the invention There are no limitations in the form of the antibodies of the invention. They include polyclonal antibodies, monoclonal antibodies, or their portions that can bind to an antigen. They also include antibodies of all classes. Furthermore, special antibodies such as humanized antibodies and chimeric antibodies are also included.
  • the polyclonal antibody of the invention can be obtained according to the standard method by synthesizing an oligopeptide corresponding to the amino acid sequence and immunizing rabbits with the peptide (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.12-11.13).
  • the monoclonal antibody of the invention can be obtained according to the standard method by purifying the polypeptide expressed in E. coli , immunizing mice with the polypeptide, and producing a hybridoma cell by fusing the spleen cells and myeloma cells (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.4-11.11).
  • the antibody binding to the polypeptide of the present invention can be used for purification of the polypeptide of the invention, and also for detection and/or diagnosis of the abnormalities of the expression and structure of the polypeptide.
  • polypeptides can be extracted, for example, from tissues, blood, or cells, and the polypeptide of the invention is detected by Western blotting, immunoprecipitation, or ELISA, etc. for the above purpose.
  • the antibody binding to the polypeptide of the present invention can be utilized for treating the diseases that associates with the polypeptide of the invention.
  • human antibodies, humanized antibodies, or chimeric antibodies are preferable in terms of their low antigenicity.
  • the human antibodies can be prepared by immunizing a mouse whose immune system is replaced with that of human (e.g., see “Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice” Mendez, M. J. et al. (1997) Nat. Genet. 15: 146-156).
  • the humanized antibodies can be prepared by recombination of the hypervariable region of a monoclonal antibody (Methods in Enzymology (1991) 203: 99-121).
  • a cDNA of the present invention encodes, for example, an amino acid sequence of a protein that is predicted to have the following function.
  • the use of the amino acid sequences of the polypeptides encoded by the cDNAs of the present invention enables predicting that the polypeptides have the following functions. It can be predict, from the results of homology search of SwissProt, GenBank, UniGene, or nr, that these polypeptides have such functions.
  • each of 1216 clones out of the 2443 full-length cDNA clones of the invention was predicted to encode a polypeptide that was classified into the following categories.
  • Enzyme and/or metabolism-related protein (206 clones)
  • Protein synthesis- and/or transport-related protein (62 clones)
  • DNA- and/or RNA-binding protein (174 clones)
  • the functions of the polypeptides encoded by the cDNAs of the present invention can be predicted by assessing the presence of signal sequence, transmembrane region, nuclear translocation signal, glycosylation signal, phosphorylation site, and zinc finger motif, SH3 domain, etc. in the amino acid sequences.
  • Biochemistry 33: 3038-3049 can be used to predict the existence of the signal sequence or transmembrane region.
  • a partial amino acid sequence of the polypeptide is fused with another polypeptide such as GFP, the fusion polypeptide is transfected into cultured cells, and the localization is analyzed to predict the function of the original polypeptide.
  • the functions are often predictable by using partial sequence information (preferably 300 nucleotides or more) instead of the full-length nucleotide sequences.
  • partial sequence information preferably 300 nucleotides or more
  • the result of the prediction by using partial nucleotide sequence does not always agree with the result obtained by using full-length nucleotide sequence, and thus, it is needless to say that the prediction of function is preferably performed based on the full-length nucleotide sequences.
  • GenBank, Swiss-Prot, UniGene and nr databases were searched for homologies of the full-length nucleotide sequences of the 2443 clones (see Example 6).
  • the amino acid sequences deduced from the full-length nucleotide sequences were searched for functional domains by PSORT, SOSUI and Pfam. Prediction of functions of polypeptides encoded by the clones and the categorization thereof were performed based on these results obtained.
  • the categorization was carried out by the following method.
  • the cDNA clones were classified into the above-mentioned 14 functional categories based on the results of annotation-based categorization (using the keywords in the case of Swiss-Prot hit data; using Definition or Reference information in the case of GenBank, UniGene, or nr hit data), and the signal sequence search of the deduced ORFs by PSORT and the transmembrane region search by SOSUI.
  • the following 206 clones presumably belong to the category of enzymes and/or metabolism-related proteins.
  • the following 33 clones presumably belong to the category of cell division- and/or cell proliferation-related proteins.
  • the following 65 clones presumably belong to the category of nuclear proteins and/or RNA synthesis-related proteins.
  • the following 62 clones presumably belong to the category of protein synthesis- and/or protein transport-related proteins.
  • the following 15 clones presumably belong to the category of cellular defense-related proteins.
  • BRCOC20144000 CTONG20092680, KIDNE20020150, LIVER20002160, NT2RI20050960, NT2RP70045590, OCBBF20128120, PLACE60003480, SKNSH20089400, SMINT20106290, SPLEN20039240, TESTI20001000, TESTI20455620, TRACH20028030, UTERU20176320
  • the following 174 clones presumably belong to the category of DNA- and/or RNA-binding proteins.
  • the following 68 clones presumably belong to the category of ATP- and/or GTP-binding proteins.
  • BRAMY20248490, FCBBF10002800, NTONG20092290, OCBBF20127040, SMINT20163960, THYMU20279750, TRACH20167220 are clones which were predicted to highly possibly belong to the category of secretory protein and/or membrane protein based on the result of domain search by Pfam.
  • FCBBF10002800 NTONG20092290, OCBBF20127040, SMINT20163960, TESTI20478850, THYMU20279750
  • the 6 clones shown above are clones which were predicted to highly possibly belong to the category of glycoprotein-related protein based on the result of domain search by Pfam.
  • the 26 clones shown above are clones which were predicted to highly possibly belong to the category of signal transduction-related protein based on the result of domain search by Pfam.
  • the 36 clones shown above are clones which were predicted to highly possibly belong to the category of transcription-related protein based on the result of domain search by Pfam.
  • the 55 clones shown above are clones which were predicted to highly possibly belong to the category of enzyme and/or metabolism-related protein based on the result of domain search by Pfam.
  • the 2 clone shown above is a clone which was predicted to highly possibly belong to the category of cell division and/or cell proliferation-related protein based on the result of domain search by Pfam.
  • FCBBF30262510 NT2NE20125050, SMINT20068010, SPLEN20163560, STOMA20092890, TESTI20382750
  • the 7 clones shown above are clones which were predicted to highly possibly belong to the category of cytoskeleton-related protein based on the result of domain search by Pfam.
  • the clone shown above is clone which was predicted to highly possibly belong to the category of Nuclear protein and/or RNA synthesis-related protein based on the result of domain search by Pfam.
  • the 6 clones shown above are clones which were predicted to highly possibly belong to the category of Protein synthesis-and/or transport-related protein based on the result of domain search by Pfam.
  • the 57 clones shown above are clones which were predicted to highly possibly belong to the category of DNA- and/or RNA-binding protein based on the result of domain search by Pfam.
  • the clone shown above is a clone which was predicted to highly possibly belong to the category of ATP- and/or GTP-binding proteins based on the result of domain search by Pfam.
  • the 213 clones shown below are clones which were unassignable to any of the above-mentioned categories, but have been predicted to have some functions based on homology search using their full-length nucleotide sequences and motif search in their estimated ORFs.
  • BRACE20276430 // Homo sapiens retinoblastoma-associated protein RAP140 mRNA, complete cds.
  • SWAP2 white apricot homolog 2
  • PROTEIN EPSILON MITOCHONDRIAL IMPORT STIMULATION FACTOR L SUBUNIT
  • PROTEIN KINASE C INHIBITOR PROTEIN-1) KCIP-1) (14-3-3E).
  • BRSSN20021600//RING CANAL PROTEIN KELCH PROTEIN
  • CTONG20076130//ZINC FINGER PROTEIN 185 (LIM-DOMAIN PROTEIN ZNF185) (P1-A).
  • CTONG20186320//RING CANAL PROTEIN (KELCH PROTEIN).
  • D9OST20031370// Homo sapiens mRNA for partial putative TCPTP-interacting protein ptpip5 gene.
  • FCBBF10005500//Keratin high sulfur B2 protein
  • FCBBF20014270//ACYL-COA-BINDING PROTEIN ACBP
  • DIBI DIBI
  • ENDOZEPINE EP
  • FCBBF30016320//SecA protein amino terminal region
  • FCBBF30246630// H. sapiens mRNA for ZYG homologue FCBBF30246630// H. sapiens mRNA for ZYG homologue.
  • BICD bicaudal-D
  • FCBBF30252800//NDRG1 PROTEIN DIFFERENTIATION-RELATED GENE 1 PROTEIN
  • DRG1 REDUCING AGENTS AND TUNICAMYCIN-RESPONSIVE PROTEIN
  • RTP NICKEL-SPECIFIC INDUCTION PROTEIN CAP43
  • FCBBF30285280//Keratin high sulfur B2 protein// Bacterial regulatory proteins, gntR family
  • FEBRA20088360//ALPHA-ADAPTIN C CLATHRIN ASSEMBLY PROTEIN COMPLEX 2 ALPHA-C LARGE CHAIN
  • 100 KDA COATED VESICLE PROTEIN C PLASMA MEMBRANE ADAPTOR HA2/AP2 ADAPTIN ALPHA C SUBUNIT.
  • MESAN20141920//Human ovarian cancer downregulated myosin heavy chain homolog (Doc1) mRNA, complete cds.
  • NT2RP70194450//Bacterial regulatory proteins crp family NTONG20052650// Gallus gallus Xin mRNA, complete cds.
  • NTONG20083650 //TPR Domain// TPR Domain// TPR Domain// PPR repeat// TPR Domain// PPR repeat// TPR Domain// PPR repeat// TPR Domain// TPR Domain
  • OCBBF20049840// Homo sapiens mRNA for neurabin II protein OCBBF20049840// Homo sapiens mRNA for neurabin II protein.
  • hCRA alpha Human cisplatin resistance associated alpha protein
  • TESTI20467970//Neurohypophysial hormones N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysi
  • TRACH20048450//PROTEIN K4 (PROTEIN K3).
  • a polypeptide does not always belong solely to a single category of the above-described functional categories, and therefore, a polypeptide may belong to any of the predicted functional categories.
  • additional functions can be found for the clones classified into these functional categories by further analyses.
  • polypeptide encoded by clones of the invention contains full-length amino acid sequence, it is possible to analyze its biological activity, and its effect on cellular conditions such as cell proliferation and differentiation by expressing the polypeptide as a recombinant polypeptide using an appropriate expression system, injecting the recombinant into the cell, or raising a specific antibody against the polypeptide.
  • the clone predicted to belong to the category of secretory and/or membrane protein means a clone having hit data with some annotation, such as growth factor, cytokine, hormone, signal, transmembrane, membrane, extracellular matrix, receptor, G-protein coupled receptor, ionic channel, voltage-gated channel, calcium channel, cell adhesion, collagen, connective tissue, etc., suggesting that it was a secretory or membrane protein, or a clone in which the presence of nucleotide sequence encoding a signal sequence or transmembrane region was suggested by the results of PSORT and SOSUI analyses for deduced ORF.
  • some annotation such as growth factor, cytokine, hormone, signal, transmembrane, membrane, extracellular matrix, receptor, G-protein coupled receptor, ionic channel, voltage-gated channel, calcium channel, cell adhesion, collagen, connective tissue, etc.
  • the clone predicted to belong to the category of glycoprotein-related protein means a clone having hit data with some annotation, such as glycoprotein, suggesting that the clone encodes a glycoprotein-related protein.
  • the clone predicted to belong to the category of signal transduction-related protein means a clone having hit data with some annotation, such as serine/threonine-protein kinase, tyrosine-protein kinase, SH3 domain, SH2 domain, etc., suggesting that the clone encodes a signal transduction-related protein.
  • the clone predicted to belong to the category of transcription-related protein means a clone having hit data with some annotation, such as transcription regulation, zinc finger, homeobox, etc., suggesting that the clone encodes a transcription-related protein.
  • the clone predicted to belong to the category of disease-related protein means a clone having hit data with some annotation, such as disease mutation, syndrome, etc., suggesting that the clone encodes a disease-related protein, or a clone whose full-length nucleotide sequence has hit data for Swiss-Prot, GenBank, UniGene, or nr, where the hit data corresponds to genes or polypeptides which have been deposited in the Online Mendelian Inheritance in Man (OMIM) (http://www.ncbi.nlm.nih.gov/Omim/), which is the human gene and disease database described later.
  • OMIM Online Mendelian Inheritance in Man
  • the clone predicted to belong to the category of enzyme and/or metabolism-related protein means a clone having hit data with some annotation, such as metabolism, oxidoreductase, E. C. No. (Enzyme commission number), etc., suggesting that the clone encodes an enzyme and/or metabolism-related protein.
  • the clone predicted to belong to the category of cell division and/or cell proliferation-related protein means a clone having hit data with some annotation, such as cell division, cell cycle, mitosis, chromosomal protein, cell growth, apoptosis, etc., suggesting that the clone encodes a cell division and/or cell proliferation-related protein.
  • the clone predicted to belong to the category of cytoskeleton-related protein means a clone having hit data with some annotation, such as structural protein, cytoskeleton, actin-binding, microtubles, etc., suggesting that the clone encodes a cytoskeleton-related protein.
  • the clone predicted to belong to the category of nuclear protein and/or RNA synthesis-related protein means a clone having hit data with some annotation, such as nuclear protein, RNA splicing, RNA processing, RNA helicase, polyadenylation, etc., suggesting that the clone encodes a nuclear protein and/or RNA synthesis-related protein.
  • the clone predicted to belong to the category of protein synthesis and/or transport-related protein means a clone having hit data with some annotation, such as translation regulation, protein biosynthesis, amino-acid biosynthesis, ribosomal protein, protein transport, signal recognition particle, etc., suggesting that the clone encodes a protein synthesis and/or transport-related protein.
  • the clone predicted to belong to the category of cellular defense-related protein means a clone having hit data with some annotation, such as heat shock, DNA repair, DNA damage, etc., suggesting that the clone encodes a cellular defense-related protein.
  • the clone predicted to belong to the category of development and/or differentiation-related proteins means a clone having hit data with some annotation, such as developmental protein, etc., suggesting that the clone encodes a development and/or differentiation-related protein.
  • the clone predicted to belong to the category of DNA-and/or RNA-binding protein means a clone having hit data with some annotation, such as DNA-binding, RNA-binding, etc.
  • the clone predicted to belong to the category of ATP-and/or GTP-binding protein means a clone having hit data with some annotation, such as ATP-binding, GTP-binding, etc.
  • a protein involved in a disease it is possible to perform a functional analysis as described above, but also possible to analyze correlation between the expression or the activity of the protein and a certain disease by using a specific antibody that is obtained by using expressed protein.
  • the database OMIM which is a database of human genes and diseases, to analyze the protein. Further, new information is constantly being deposited in the OMIM database. Therefore, it is possible for one skilled in the art to find a new relationship between a particular disease and a gene of the present invention in the most up-to-date database.
  • the proteins involved in diseases are useful for developing a diagnostic marker or medicines for regulation of their expression and activity, or as a target of gene therapy.
  • *120940, 140300 *151690, *120700, *602354, *600019, *600857, *182175, *600536, *158380, *600516, *120290, *600493, *182310, #252010, *182530, *186830, *601839, *142790, *159465, *118990, *250790, *248600, #248250, *186845, *601153, *142600, *116930, *114860, *171834, #303600, *186880, *600444, *142871, *601852, *602602, *602607, *114207, *186910, #232220,
  • nucleotide sequences of cDNAs of the present invention enables analyzing the expression frequency of genes corresponding to the cDNAs.
  • functions of the genes can be predicted based on the information obtained by the expression frequency analysis.
  • BODYMAP there is a database called “BODYMAP”; gene clones are extracted at random from cDNA libraries of various tissues and/or cells, and the clones homologous to one another are assigned to a single cluster based on the information of nucleotide sequence homology at the 3′-end; genes are classified into any clusters, and the numbers of clones in the respective clusters are compared to gain the information on expression frequency (http://bodymap.ims.utokyo.ac.jp/).
  • genes involved in particular pathology or functions were selected by the use of databases shown below (see Example 7; “Expression frequency analysis in silico”).
  • the database used in the analyses of the present invention contains nucleotide sequences of 1,402,070 clones, and the population of the database is large enough for the analysis.
  • the sequence information in the database was obtained by selecting cDNA clones at random from cDNA libraries derived from the various tissues and cells shown in Example 1 and determining the 5′-end sequences thereof.
  • nucleotide sequences of respective clones in this database were categorized (clustered) based on the nucleotide sequence homology determined with a search program; the number of clones belonging to every cluster of each library was determined and normalized; thus, the ratio of a certain gene in a cDNA library was determined.
  • This analysis provided the information of the expression frequency of a gene in a tissue or cell that is the source of the cDNA library.
  • the libraries from the tissues or cells, which had been used in the large-scale cDNA analyses were taken as subjects to compare the expression levels between different tissues or cells.
  • the expression frequency was analyzed by comparing the previously normalized values between tissues or cells from which 600 or more cDNA clones whose nucleotide sequences had been analyzed were derived. The result of this analysis showed that the cDNA clones corresponded to the genes involved in the pathology and functions, which are indicated below.
  • Each value in Tables 3 to 51 indicated below represents a relative expression frequency; the higher the value, the higher the expression level.
  • Osteoporosis is a pathology in which bones are easily broken owing to overall decrease in components of bone. The onset correlates to the balance between the functions of osteoblast producing bone and osteoclast absorbing bone, namely bone metabolism.
  • the genes involved in the increase of osteoclasts differentiating from precursor cells of monocyte/macrophage line are genes involved in osteoporosis relevant to bone metabolism.
  • a nucleotide sequence information-based analysis was carried out to identify the genes whose expression frequencies are higher or lower in CD34+ cell (cell expressing a glycoprotein CD34) treated with the osteoclast differentiation factor (Molecular Medicine 38. 642-648. (2001)) than in the untreated CD34+ cell, which is the precursor cell of monocyte/macrophage line.
  • the result of comparative analysis for the frequency between the cDNA libraries prepared from the RNA of CD34+ cells (CD34C) and from the RNA of CD34+ cells treated with the osteoclast differentiation factor (D30ST, D60ST or D90ST) showed that the genes whose expression levels were different between the two were 56 clones indicated in Table 3. These clones are involved in osteoporosis.
  • Genes involved in neural cell differentiation are useful for treating neurological diseases. Genes with varying expression levels in response to induction of cellular differentiation in neural cells are thought to be involved in neurological diseases.
  • NT2RM undifferentiated NT2 cells
  • NT2R1 or NT2NE the cells subjected to the differentiation treatment
  • cancer tissues express a distinct set of genes, and thus the expression thereof can contribute to the carcinogenesis in tissues and cells.
  • genes whose expression patterns in cancer tissues are different from those in normal tissues are cancer-related genes. Search was carried out for the genes whose expression levels in cancer tissues were different from those in normal tissues.
  • genes involved in development and differentiation which is the expression frequency analysis in which the expression levels of genes are compared between developing and/or differentiating tissues and/or cells and adult tissues and/or cells.
  • the genes involved in tissue development and/or differentiation are genes participating in tissue construction and expression of function, and thus are useful genes, which are available for regenerative medicine aiming at convenient regeneration of injured tissues.
  • genes involved in development or differentiation of particular tissues were selected from the 2443 clones whose full-length nucleotide sequence had been revealed (see Example 7).
  • the expression frequency or the like can be analyzed by PCR based on the nucleotide sequences of cDNAs of the present invention.
  • the band intensities can be determined by ethidium bromide staining.
  • the R1 signal or fluorescence intensity can be assayed for the quantity of labeled amplification products.
  • the quantity of amplification products can also be determined by measuring the R1 signal or the fluorescence intensity from the R1-labeled or fluorescently labeled probe hybridizing to the products. The assay results thus obtained are compared and then the clones exhibiting differences in the expression levels can be selected.
  • PCR methods There are some quantitative PCR methods: a PCR method using internal standards; a competitive PCR, in which the quantification is achieved by adding, to a sample, a dilution series of a known quantity of a template RNA and by comparing the quantity of an amplification product derived from the RNA of interest with the quantity of an amplification product derived from the template RNA.
  • ATAC-PCR Adaptor-tagged competitive PCR
  • ATAC-PCR is a method of competitive PCR which is practiced by using multiple adapters of different sizes attached to a gene whose 3′-end nucleotide sequence has previously been determined.
  • the ratio of expression frequency of a single mRNA species from a number of tissues (cells) can be assayed in a single step (Nucleic Acids Research 1997, 25(22): 4694-4696; “DNA Micro-array and Advanced PCR Techniques”, Cell Technology, supplement, Eds., Muramatsu and Nawa (Shujunsha, 2000): 104-112).
  • genes exhibiting tissue-specific expression are genes playing important parts in the tissue functions and, therefore, can be candidates for genes involved in diseases and/or disorders affecting the tissues.
  • inflammation is an important biological response that is known to be involved in various diseases.
  • the representative inflammation-inducing factors include TNF-a (Tumor Necrosis Factor-alpha).
  • TNF-a Tumor Necrosis Factor-alpha
  • NF- ⁇ B is a transducing molecule
  • IL-2, IL-6 and G-CSF are varied in the expression levels thereof in response to the signal through the pathway.
  • THP-1 cell which is a human monocyte cell line, was cultured in the presence of TNF- ⁇ (Tumor Necrosis Factor-alpha)
  • TNF- ⁇ Tumor Necrosis Factor-alpha
  • the genes whose expression levels were altered owing to the presence of TNF- ⁇ were searched for, and the result showed that the clones whose expression levels were increased owing to the presence of TNF- ⁇ were ASTRO20152140, BRACE20057620,
  • BRACE20060720 BRACE20090440, BRACE20152870, BRACE20229280, BRAMY20002770, BRAMY20266850, BRAMY20280720, BRAWH20106180, BRAWH20122770, BRHIP20096170, BRHIP20111200, BRHIP20186120, BRHIP20194940, BRHIP20207430, BRSSN20152380, CTONG20095270, CTONG20100240, CTONG20158150,
  • These clones are inflammation-related genes.
  • MKN45 which is a gastric cancer cell line
  • HCV45 which is a gastric cancer cell line
  • the genes whose expression levels were altered owing to the presence of Helicobacter pylori were searched for, and the result showed that the clones whose expression levels were increased owing to the presence of Helicobacter pylori were ADRGL20067670, BLADE20004630,
  • BRACE20039040 BRACE20151320, BRACE20229280, BRACE20235400, BRALZ20058880, BRAMY20060920, BRAMY20184670, BRAMY20218670, BRAMY20229800, BRCAN20147880, BRHIP20196410, BRHIP30004880, BRSSN20187310, CD34C30004940, CTONG20265130, DFNES20031920, FCBBF30278630, FCBBF40001420,
  • the polypeptide encoded by the cDNA of the present invention is a regulatory factor of cellular conditions such as growth and differentiation
  • it can be used for developing medicines as follows.
  • the polypeptide or antibody provided by the invention is injected into a certain kind of cells by microinjection. Then, using the cells, it is possible to screen low molecular weight compounds, etc. by measuring the change in the cellular conditions, or the activation or inhibition of a particular gene.
  • the screening can be performed as follows.
  • the polypeptide is expressed and purified as recombinant.
  • the purified polypeptide is microinjected into cells such as various cell lines, or primary culture cells, and the cellular change such as growth and differentiation can be examined.
  • the induction of genes whose expression is known to be involved in a particular change of cellular conditions may be detected by the amount of mRNA or polypeptide.
  • the amount of intracellular molecules (low molecular weight compounds, etc.) that is changed by the function of the gene product (polypeptide) which is known to be involved in a particular change of cellular conditions may be detected.
  • the compounds to be screened can be added to the culture media and assessed for their activity by measuring the change of the cellular conditions.
  • cell lines introduced with the gene obtained in the invention can be used for the screening. If the gene product is turn out to be involved in a particular change in the cellular conditions, the change of the product can be used as a measurement for screening. Once a compound is screened out which can activate or inhibit the function of the polypeptide of the invention, it can be applied for developing medicines.
  • polypeptide encoded by the cDNA of the present invention is a secretory protein, membrane protein, or protein involved in signal transduction, glycoprotein, transcription, or diseases, it can be used in functional assays for developing medicines.
  • a membrane protein In case of a membrane protein, it is most likely to be a polypeptide that functions as a receptor or ligand on the cell surface. Therefore, it is possible to reveal a new relationship between a ligand and receptor by screening the membrane protein of the invention based on the binding activity with the known ligand or receptor. Screening can be performed according to the known methods.
  • a ligand against the polypeptide of the invention can be screened in the following manner. Namely, a ligand that binds to a specific polypeptide can be screened by a method comprising the steps of: (a) contacting a test sample with the polypeptide of the invention or a partial peptide thereof, or cells expressing these, and (b) selecting a test sample that binds to said polypeptide, said partial peptide, or said cells.
  • screening using cells expressing the polypeptide of the present invention that is a receptor protein can also be performed as follows. It is possible to screen receptors that is capable of binding to a specific polypeptide by using procedures (a) attaching the sample cells to the polypeptide of the invention or its partial peptide, and (b) selecting cells that can bind to the said polypeptide or its partial peptide.
  • the polypeptide of the invention is expressed, and the recombinant polypeptide is purified.
  • the purified polypeptide is labeled, binding assay is performed using a various cell lines or primary cultured cells, and cells that are expressing a receptor are selected (Growth and differentiation factors and their receptors, Shin-Seikagaku Jikken Kouza Vol. 7 (1991) Honjyo, Arai, Taniguchi, and Muramatsu edit, p203-236, Tokyo-Kagaku-Doujin).
  • a polypeptide of the invention can be labeled with RI such as 125 I, and enzyme (alkaline phosphatase etc.).
  • a polypeptide of the invention may be used without labeling and then detected by using a labeled antibody against the polypeptide.
  • the cells that are selected by the above screening methods, which express a receptor of the polypeptide of the invention, can be used for the further screening of an agonists or antagonists of the said receptor.
  • the receptor of the polypeptide of the invention or the cells expressing the receptor are obtained by screening, it is possible to screen a compound that binds to the ligand and receptor. Also it is possible to screen a compound that can inhibit both bindings (agonists or antagonists of the receptor, for example) by utilizing the binding activities.
  • the screening method comprises the steps of (a) contacting the polypeptide of the invention or cells expressing the polypeptide of the invention with the ligand, in the presence of a test sample, (b) detecting the binding activity between said polypeptide or cells expressing said polypeptide and the ligand, and (c) selecting a compound that reduces said binding activity when compared to the activity in the absence of the test sample.
  • the screening method comprises the steps of (a) contacting the polypeptide of the invention with its receptor or cells expressing the receptor in the presence of samples, (b) detecting the binding activity between the polypeptide and its receptor or the cells expressing the receptor, and (c) selecting a compound that can potentially reduce the binding activity compared to the activity in the absence of the sample.
  • Samples to screen include cell extracts, expressed products from a gene library, synthesized low molecular compound, synthesized peptide, and natural compounds, for example, but are not construed to be listed here.
  • a compound that is isolated by the above screening using a binding activity of the polypeptide of the invention can also be used as a sample.
  • a compound isolated by the screening may be a candidate to be an agonist or an antagonist of the receptor of the polypeptide.
  • an assay that monitors a change in the intracellular signaling such as phosphorylation which results from reduction of the binding between the polypeptide and its receptor, it is possible to identify whether the obtained compound is an agonist or antagonist of the receptor.
  • the compound may be a candidate of a molecule that can inhibit the interaction between the polypeptide and its associated proteins (including a receptor) in vivo. Such compounds can be used for developing drugs for precaution or cures of a disease in which the polypeptide is involved.
  • Secretory proteins may regulate cellular conditions such as growth and differentiation. It is possible to find out a novel factor that regulates cellular conditions by adding the secretory protein of the invention to a certain kind of cell, and performing a screening by utilizing the cellular changes in growth or differentiation, or activation of a particular gene.
  • the screening can be performed, for example, as follows. First, the polypeptide of the invention is expressed and purified in a recombinant form. Then, the purified polypeptide is added to a various kind of cell lines or primary cultured cells, and the change in the cell growth and differentiation is monitored. The induction of a particular gene that is known to be involved in a certain cellular change is detected by the amounts of mRNA and polypeptide. Alternatively, the amount of an intracellular molecule (low-molecular-weight compounds, etc.) that is changed by the function of a gene product (polypeptide) that is known to function in a certain cellular change is used for the detection.
  • the polypeptide of the invention is expressed and purified in a recombinant form. Then, the purified polypeptide is added to a various kind of cell lines or primary cultured cells, and the change in the cell growth and differentiation is monitored. The induction of a particular gene that is known to be involved in a certain cellular change is detected by the amounts
  • the polypeptide of the invention can regulate cellular conditions or the functions, it is possible to apply the polypeptide as a pharmaceutical and diagnostic medicine for related diseases by itself or by altering a part of it into an appropriate composition.
  • the secretory protein provided by the invention may be used to explore a novel ligand-receptor interaction using a screening based on the binding activity to a known ligand or receptor.
  • a similar method can be used to identify an agonist or antagonist.
  • the resulting compounds obtained by the methods can be a candidate of a compound that can inhibit the interaction between the polypeptide of the invention and an interacting molecule (including a receptor).
  • the compounds may be able to use as a preventive, therapeutic, and diagnostic medicine for the diseases, in which the polypeptide may play a certain role.
  • Proteins involved in signal transduction or transcription may be a factor that affects a certain polypeptide or gene in response to intracellular/extracellular stimuli. It is possible to find out a novel factor that can affect a polypeptide or gene by expressing the polypeptide provided by the invention in a certain types of cells, and performing a screening utilizing the activation of a certain intracellular polypeptide or gene.
  • the screening may be performed as follows. First, a transformed cell line expressing the polypeptide is obtained. Then, the transformed cell line and the untransformed original cell line are compared for the changes in the expression of a certain gene by detecting the amount of its mRNA or polypeptide. Alternatively, the amount of an intracellular molecule (low molecular weight compounds, etc.) that is changed by the function of a certain gene product (polypeptide) may be used for the detection.
  • the change of the expression of a certain gene can be detected by introducing a fusion gene that comprises a regulatory region of the gene and a marker gene (luciferase, ⁇ -galactosidase, etc.) into a cell, expressing the polypeptide provided by the invention into the cell, and estimating the activity of a marker gene product (polypeptide).
  • a marker gene luciferase, ⁇ -galactosidase, etc.
  • polypeptide or gene of the invention is involved in diseases, it is possible to screen a gene or compound that can regulate its expression and/or activity either directly or indirectly by utilizing the polypeptide of the present invention.
  • the polypeptide of the invention is expressed and purified as a recombinant polypeptide. Then, the polypeptide or gene that interacts with the polypeptide of the invention is purified, and screened based on the binding. Alternatively, the screening can be performed by adding with a compound of a candidate of the inhibitor added in advance and monitoring the change of binding activity.
  • a transcription regulatory region locating in the 5′-upstream of the gene encoding the polypeptide of the invention that is capable of regulating the expression of other genes is obtained, and fused with a marker gene. The fusion is introduced into a cell, and the cell is added with compounds to explore a regulatory factor of the expression of the said gene.
  • the compound obtained by the screening can be used for developing pharmaceutical and diagnostic medicines for the diseases in which the polypeptide of the present invention is involved.
  • the regulatory factor obtained in the screening is turn out to be a polypeptide
  • compounds that can newly affect the expression or activity of the polypeptide may be used as a medicine for the diseases in which the polypeptide of the invention is involved.
  • the polypeptide of the invention has an enzymatic activity, regardless as to whether it is a secretory protein, membrane protein, or proteins involved in signal transduction, glycoprotein, transcription, or diseases, a screening may be performed by adding a compound to the polypeptide of the invention and monitoring the change of the compound.
  • the enzymatic activity may also be utilized to screen a compound that can inhibit the activity of the polypeptide.
  • the polypeptide of the invention is expressed and the recombinant polypeptide is purified. Then, compounds are contacted with the purified polypeptide, and the amount of the compound and the reaction products is examined. Alternatively, compounds that are candidates of an inhibitor are pretreated, then a compound (substrate) that can react with the purified polypeptide is added, and the amount of the substrate and the reaction products is examined.
  • the compounds obtained in the screening may be used as a medicine for diseases in which the polypeptide of the invention is involved. Also they can be applied for tests that examine whether the polypeptide of the invention functions normally in vivo.
  • the secretory protein, membrane protein, signal transduction-related protein, glycoprotein-related protein, or transcription-related protein of the present invention is a novel protein involved in diseases or not is determined in another method than described above, by obtaining a specific antibody against the polypeptide of the invention, and examining the relationship between the expression or activity of the polypeptide and a certain disease. In an alternative way, it may be analyzed referred to the methods in “Molecular Diagnosis of Genetic Diseases” (Elles R. edit, (1996) in the series of “Method in Molecular Biology” (Humana Press).
  • Proteins involved in diseases are targets of screening as mentioned, and thus are very useful in developing drugs which regulate their expression and activity. Also, the proteins are useful in the medicinal industry as a diagnostic marker of the related disease or a target of gene therapy.
  • Compounds isolated as mentioned above can be administered patients as it is, or after formulated into a pharmaceutical composition according to the known methods.
  • a pharmaceutically acceptable carrier or vehicle specifically sterilized water, saline, plant oil, emulsifier, or suspending agent can be mixed with the compounds appropriately.
  • the pharmaceutical compositions can be administered to patients by a method known to those skilled in the art, such as intraarterial, intravenous, or subcutaneous injections. The dosage may vary depending on the weight or age of a patient, or the method of administration, but those skilled in the art can choose an appropriate dosage properly.
  • the compound is encoded by polynucleotide, the polynucleotide can be cloned into a vector for gene therapy, and used for gene therapy.
  • the dosage of the polynucleotide and the method of its administration may vary depending on the weight or age of a patient, or the symptoms, but those skilled in the art can choose properly.
  • the present invention further relates to databases comprising at least a sequence of polynucleotide and/or polypeptide, or a medium recorded in such databases, selected from the sequence data of the nucleotide and/or the amino acids indicated in Table 1.
  • database means a set of accumulated information as machine-searchable and readable information of nucleotide sequence.
  • the databases of the present invention comprise at least one of the novel nucleotide sequences of polynucleotides provided by the present invention.
  • the databases of the present invention can consist of only the sequence data of the novel polynucleotides provided by the present invention or can comprise other information on nucleotide sequences of known full-length cDNAs or ESTs.
  • the databases of the present invention can be comprised of not only the information on the nucleotide sequences but also the information on the gene functions revealed by the present invention. Additional information such as names of DNA clones carrying the full-length cDNAs can be recorded or linked together with the sequence data in the databases.
  • the database of the present invention is useful for gaining complete gene sequence information from partial sequence information of a gene of interest.
  • the database of the present invention comprises nucleotide sequence information of full-length cDNAs. Consequently, by comparing the information in this database with the nucleotide sequence of a partial gene fragment yielded by differential display method or subtraction method, the information on the full-length nucleotide sequence of interest can be gained from the sequence of the partial fragment as a starting clue.
  • the sequence information of the full-length cDNAs constituting the database of the present invention contains not only the information on the complete sequences but also extra information on expression frequency of the genes as well as homology of the genes to known genes and known polypeptides. Thus the extra information facilitates rapid functional analyses of partial gene fragments. Further, the information on human genes is accumulated in the database of the present invention, and therefore, the database is useful for isolating a human homologue of a gene originating from other species. The human homologue can be isolated based on the nucleotide sequence of the gene from the original species.
  • gene fragments can be obtained by differential display method and subtraction method.
  • these gene fragments are utilized as tools for isolating the full-length sequences thereof.
  • the full-length sequence is easily obtained by comparing the partial sequence with the information in known databases.
  • cDNA cloning should be carried out for the full-length cDNA. It is often difficult to obtain the full-length nucleotide sequence using the partial sequence information as an initial clue. If the full-length of the gene is not available, the amino acid sequence of the polypeptide encoded by the gene remains unidentified.
  • the database of the present invention can contribute to the identification of full-length cDNAs corresponding to gene fragments, which cannot be revealed by using databases of known genes.
  • the present invention has provided 2443 polynucleotides. As has not yet proceeded the isolation of full-length cDNA within the human, the invention has great significance. It is known that secretory proteins, membrane proteins, signal transduction-related proteins, glycoprotein-related proteins, transcription-related proteins, and so on are involved in many diseases. The genes and proteins involved in diseases are useful for developing a diagnostic marker or medicines for regulation of their expression and activity, or as a target of gene therapy.
  • cDNA assumed to encode secretory proteins which were provided by this invention, are very important for the industry since the encoded proteins themselves are expected to be useful as pharmaceutical agents and many disease-related genes may be included in them.
  • membrane proteins, signal transduction-related proteins, transcription-related proteins, disease-related proteins, and genes encoding them can be used as indicators for diseases, etc.
  • cDNA are also very important for the industry, which are expected to regulate the activity or expression of the encoded protein to treat diseases, etc.
  • RNAs as mRNA sources were extracted from human tissues (shown below) by the method as described in the reference (J. Sambrook, E. F. Fritsch & T. Maniatis, Molecular Cloning Second edition, Cold Spring harbor Laboratory Press, 1989). Further, by the method as described in the reference (J. Sambrook, E. F. Fritsch & T. Maniatis, Molecular Cloning Second edition, Cold Spring harbor Laboratory Press, 1989), total RNAs as mRNA sources were extracted from human culture cells and human primary culture cells (shown below) which had been cultivated by the methods described in the catalogs.
  • the library names and the origins are indicated below in the order of “Library name: Origin”.
  • Library name: Origin When a library was prepared by the subtraction method, the item is followed by a description of how to prepare the subtracted library.
  • NTONG Normal tongue
  • CTONG Tongue cancer
  • FCBBF Fetal brain
  • OCBBF Fetal brain
  • SYNOV Synovial membrane tissue (from rheumatioid arthritis);
  • BNGH4 H4 cells (ATCC #HTB-148);
  • IMR32 IMR32 cells (ATCC #CCL-127);
  • SKNMC SK-N-MC cells (ATCC #HTB-10);
  • 3NB69 NB69 cells (RCB #RCB0480);
  • BGGI1 GI1 cells (RCB #RCB0763);
  • NB9N4 NB9 cells (RCB #RCB0477);
  • SKNSH SK-N-SH cells (RCB #RCB0426);
  • AHMSC Human mesenchymal (HMSC) cells
  • CHONS Chondrocytes
  • ERLTF TF-1 cells (erythroleukemia);
  • HELAC HeLa cells
  • JCMLC Leukemia, myelogenous
  • MESTC Mesenchyme stem cells
  • N1ESE Mesenchymal stem cells
  • NCRRM Embryonal carcinoma
  • NCRRP Embryonal carcinoma treated with retinoic acid (RA) to induce the differentiation
  • T1ESE Mesenchymal stem cells treated with trichostatin and 5-azacytidine to induce the differentiation
  • NT2RM NT2 cells (STARATAGENE #204101);
  • NT2RP NT2 cells treated with retinoic acid (RA) for 5 weeks to induce the differentiation
  • NT2R1 NT2 cells treated with RA for 5 weeks to induce the differentiation, followed by the treatment with the growth inhibitor for 2 weeks;
  • NT2NE NT2 cells were treated with RA and the growth inhibitor for the neuronal differentiation, and the resultant neurons were concentrated and harvested (NT2 Neuron);
  • NTISM NTISM: NT2 cells (STARATAGENE #204101) were treated with RA for 5 weeks to induce the differentiation, and then treated with the growth inhibitor for 2 weeks; mRNA was prepared from the cells and a cDNA library was constructed from the mRNA; the cDNAs of the library whose nucleotide sequences were shared by those of mRNAs from undifferentiated NT2 cells were subtracted by using a Subtract Kit (Invitrogen #K4320-01); the subtracted library (NT2R1-NT2RM) was provided by this procedure.
  • RCB indicates that the cell was provided by the Cell Bank, RIKEN GENE BANK, The Institute of Physical and Chemical Research; ATCC indicates that the cell was provided by American Type Culture Collection.
  • DFNES Normal human dermal fibroblast (neonatal skin); NHDF-Neo
  • MESAN Normal human mesangial cell NHMC56046-2, Takara Shuzo #CC2559;
  • NHNPC Normal human neural progenitor cell NHNP5958, Takara Shuzo #CC2599;
  • PEBLM Normal human peripheral blood mononuclear cell HPBMC5939, Takara Shuzo #CC2702;
  • HSYRA Human synoviocyte HS-RA (from rheumatioid arthritis), Toyobo #T404K-05;
  • PUAEN Normal human pulmonary artery endothelial cells, Toyobo #T302K-05;
  • UMVEN Normal human umbilical vein endothelial cell HUVEC, Toyobo #T200K-05;
  • HCASM Normal human coronary artery smooth muscle cell HCASMC, Toyobo #T305K-05;
  • HCHON Normal human chondrocyte HC, Toyobo #T402K-05;
  • HHDPC Normal human dermal papilla cell HDPC, Toyobo #THPCK-001;
  • CD34C CD34+ cells (AllCells, LLC #CB14435M);
  • D3OST CD34+ cells treated with the osteoclast differentiation factor (ODF) for 3 days to induce the differentiation;
  • D6OST CD34+ cells treated with ODF for 6 days to induce the differentiation
  • D9OST CD34+ cells treated with ODF for 9 days to induce the differentiation
  • ACTVT Activated T-cells
  • LYMPB Lymphoblasts, EB virus transferred B cells
  • RNAs extracted from the following human tissues were purchased and used as mRNA sources.
  • the library names and the origins are indicated below in the order of “Library name: Origin”.
  • ADRGL Adrenal gland, CLONTECH #64016-1;
  • BRACE Brain (cerebellum), CLONTECH #64035-1;
  • BRAWH Whole brain, CLONTECH #64020-1;
  • FEBRA Fetal brain, CLONTECH #64019-1;
  • FELIV Fetal liver, CLONTECH #64018-1;
  • HLUNG Lung, CLONTECH #64023-1;
  • KIDNE Kidney, CLONTECH #64030-1;
  • MAMGL Mammary Gland, CLONTECH #64037-1;
  • PROST Prostate, CLONTECH #64038-1;
  • SALGL Salivary Gland, CLONTECH #64026-1;
  • TCERX Cervix (Tumor), CLONTECH #64010-1;
  • TCOLN Colon (Tumor), CLONTECH #64014-1;
  • THYMU Thymus, CLONTECH #64028-1;
  • TLUNG Lung (Tumor), CLONTECH #64013-1;
  • TOVAR Ovary (Tumor), CLONTECH #64011-1;
  • ADIPS Adipose, Invitrogen #D6005-01;
  • BRALZ Cerebral cortex from an Alzheimer patient (Brain, cortex, Alzheimer), Invitrogen #D6830-01;
  • CERVX Cervix, Invitrogen #D6047-01;
  • PERIC Pericardium, Invitrogen #D6105-01;
  • TESOP Esophageal (Tumor), Invitrogen #D6860-01;
  • TKIDN Kidney (Tumor), Invitrogen #D6870-01;
  • TLIVE Liver (Tumor), Invitrogen #D6880-01;
  • TSTOM Stomach (Tumor), Invitrogen #D6920-01;
  • FEHRT Fetal heart, STARATAGENE #738012;
  • FEKID Fetal kidney, STARATAGENE #738014;
  • FELNG Fetal lung, STARATAGENE #738020;
  • BRASW subtracted library (BRALZ-BRAWH).
  • a cDNA library was constructed from mRNA prepared from tissues of cerebral cortex obtained from an Alzheimer patient [BRALZ: Cerebral cortex from an Alzheimer patient (Brain, cortex, Alzheimer), Invitrogen #D6830-01]; the cDNAs of this library whose nucleotide sequences were shared by those of mRNAs from whole brain tissue [BRAWH: Whole brain, CLONTECH #64020-1] were subtracted by using a Subtract Kit (Invitrogen #K4320-01).
  • RNAs extracted and purified as poly A(+) RNAs from the human tissues shown below were purchased.
  • a cDNA library was prepared from an RNA mixture in which the poly A(+) RNA from each tissue had been combined with poly A( ⁇ ) RNA.
  • the poly A( ⁇ ) RNA was prepared by removing poly A(+) RNA from the total RNA of whole brain tissue (CLONTECH #64020-1) by using oligo dT cellulose.
  • the library names and the origins are indicated below in the order of “Library name: Origin”.
  • BRAMY Brain (amygdala), CLONTECH #6574-1;
  • BRCAN Brain (caudate nucleus), CLONTECH #6575-1;
  • BRCOC Brain (corpus callosum), CLONTECH #6577-1;
  • BRHIP Brain (hippocampus), CLONTECH #6578-1;
  • BRSSN Brain (substantia nigra), CLONTECH #6580-1;
  • BRSTN Brain (subthalamic nucleus), CLONTECH #6581-1;
  • BRTHA Brain (thalamus), CLONTECH #6582-1.
  • cDNA library was prepared from each RNA by the improved method (WO 01/04286) of oligo capping [M. Maruyama and S. Sugano, Gene, 138: 171-174 (1994)].
  • the single-stranded cDNA was converted to a double-stranded cDNA by PCR (polymerase chain reaction) using 5′ (SEQ ID NO: 5457) and 3′ (SEQ ID NO: 5458) PCR primers, and then digested with SfiI. Then, a fraction of cDNA fragments, typically 2-kb or longer (3-kb or longer in some cases), was unidirectionally cloned into a DraIII-digested pME18SFL3 vector ( FIG. 1 ) (GenBank AB009864, Expression vector); the cDNA library was thus prepared.
  • the cDNA library with the high fullness ratio (the fullness ratio of 5′-end, which was calculated for each cDNA library by using the protein coding region found in known mRNA species as an index, was 90% in average) prepared by the improved oligo-capping method was constructed by using a eukaryotic expression vector pME18SFL3.
  • the vector contains SR ⁇ promoter and SV40 small t intron in the upstream of the cloning site, and SV40 polyA added signal sequence site in the downstream.
  • the cloning site of pME18SFL3 has asymmetrical DraIII sites, and the ends of cDNA fragments contain SfiI sites complementary to the DraIII sites, the cloned cDNA fragments can be inserted into the downstream of the SR ⁇ promoter unidirectionally. Therefore, clones containing full-length cDNA can be expressed transiently by introducing the obtained plasmid directly into COS cells, etc. Thus, the clones can be analyzed very easily in terms of the proteins that are the gene products of the clones, or in terms of the biological activities of the proteins.
  • the nucleotide sequences of cDNA 5′-ends (3′-ends as well in some cases) were determined in a DNA sequencer (ABI PRISM 3700, PE Biosystems), after sequencing reaction was conducted by using a DNA sequencing reagent (BigDye Terminator Cycle Sequencing FS Ready Reaction Kit, PE Biosystems) according to the manual.
  • a database was constructed based on the obtained data.
  • the 5′-end completeness of about 1110,000 clones derived from the human cDNA libraries prepared by the improved oligo-capping method was determined by the following method.
  • the clones whose 5′-end sequences were consistent with those of known human mRNA in the public database were judged to be “full-length” if they had a longer 5′-end sequence than that of the known human mRNA; or even though the 5′-end sequence was shorter, if it contained the translation initiation codon it was judged to have the “full-length” sequence. Clones which did not contain the translation initiation codon were judged to be “not-full-length”.
  • the fullness ratio ((the number of full-length clones)/(the number of full-length and not-full-length clones)) at the 5′-end of the cDNA clones was determined by comparing with known human mRNA. As a result, the fullness ratio of the 5′-ends was 90%. The result indicates that the fullness ratio at the 5′-end sequence was extremely high in the human cDNA clones obtained by the oligo-capping method.
  • the 5′-end nucleotide sequences of the cDNAs were determined in a DNA sequencer (ABI PRISM 3700, PE Biosystems), after sequencing reaction was conducted by using a DNA sequencing reagent (Dye Terminator Cycle Sequencing FS Ready Reaction Kit, dRhodamine Terminator Cycle Sequencing FS Ready Reaction Kit or BigDye Terminator Cycle Sequencing FS Ready Reaction Kit, PE Biosystems) according to the manual.
  • a database was constructed using the data obtained.
  • the data with the annotation of “complete cds” in the GenBank and UniGene were searched by BLAST homology search. When identical to certain human mRNA sequences, such cDNA clones were excluded. Then, clustering was carried out. When the identity was 90% or higher, and the length of consensus sequence was 50 base pairs or longer, the cDNA clones were assumed to belong to an identical cluster, and thus clustered. cDNA clones longer in the 5′ direction were selected from the members belonging to a cluster; if required, the 3′-end sequences of the selected clones were determined by the same analysis method as used to determine the 5′-end sequences.
  • the data of the end sequences obtained were analyzed, and then the clones forming a sequence contig at 5′- and 3′-ends were excluded. Further, as mentioned above, the data was analyzed again by BLAST homology search; when identical to certain human mRNA sequences (including sequences patented and applied for), the cDNA clones were excluded. Thus, the cDNAs clones to be analyzed for their nucleotide sequence were obtained.
  • the full-length nucleotide sequences of the selected clones were determined.
  • the nucleotide sequence determination was mainly performed by primer walking method comprising the dideoxy terminator method using custom-made synthetic DNA primers. Namely, the nucleotide sequences of the DNAs were determined in a sequencer from PE Biosystems, after sequencing reaction was carried out with a DNA sequencing reagent from the same supplier using the custom-made synthetic DNA primers according to the manual. A part of the clones were analyzed with a DNA sequencer from Licor.
  • nucleotide sequences of a part of the clones were determined by the shotgun method where the plasmids containing the cDNAs were digested at random were used, instead of the use of custom-made primers, by the same method in the DNA sequencer.
  • the full-length nucleotide sequences were finally determined by completely assembling the partial nucleotide sequences obtained by the above method.
  • GenBank, SwissProt, UniGene, and nr were searched by BLAST.
  • the clones exhibiting higher homology, which were convenient to predict their functions based on the nucleotide sequences and deduced amino acid sequences, were selected based on the BLAST search hit data whose P value or E value was 10 ⁇ 4 or lower and for which the length of consensus sequence ⁇ homology 30 or higher in the amino acid database search. Further, from them, representative clones were selected, which are shown as Homology Search Result Data in the last part herein. Accordingly, the data shown herein are merely the representative data, and the molecule exhibiting homology to each clone is not limited thereto. Further, with respect to a part of clones, the BLAST search hit data that did not meet the criteria as described above are not shown herein.
  • amino acid sequence in which the signal sequence at the amino terminus or transmembrane domain had been predicted to be present by PSORT or SOSUI were assumed to be a secretory or membrane protein.
  • the protein function can be predicted based on the hit data, for example, by referring to the function categories on the PROSITE (http://www.expasy.ch/cgi-bin/prosite-list.pl).
  • the functional domain search can also be carried out on the PROSITE.
  • the clones whose deduced amino acid sequences were detected to have the signal sequences by PSORT are as follows.
  • the clones whose deduced amino acid sequences were detected to have the transmembrane domains by SOSUI are as follows. Numerals indicate the numbers of transmembrane domains detected in the deduced amino acid sequences. Of the search result, the clone name and the number of transmembrane domains are demarcated by a double slash mark (//).
  • OCBBF20180840//1 PANCR10000910//3, PEBLM20024320//2, PEBLM20040150//2, PEBLM20074370//1, PERIC20004220//4, PLACE60121080//1, PLACE60161600//2, PLACE60177140//6, PROST20005050//1, PROST20050670//1, PROST20107820//4, PROST20116600//2, PROST20120160//1, PROST20127800//3, PROST20146010//3, PROST20164440//3, PROST20169800//1, PROST20170980//1, PROST20191640//1,
  • the Names of clones whose deduced amino acid sequences were detected to have functional domains with Pfam, and the name of hit functional domains are as follows.
  • the search result is indicated as “clone name//functional domain name”.
  • the clone has multiple hit functional domains, they are listed and demarcated by a double slash mark (//).
  • the clone has multiple hits of an identical functional domain, each is listed without abridgment.
  • ADIPS20004250//Zinc finger C2H2 type// DNA binding domain with preference for// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type// UvrD/REP helicase// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// DNA binding domain with preference for// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type// UvrD/REP helicase/// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger
  • ASTRO20072210//PDZ domain Also known as DHR or GLGF.
  • ASTRO20168470//Zinc finger C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type
  • BLADE20003400//Zinc finger C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BLADE20003890//KRAB box// Zinc finger C2H2 type// Zinc finger, C2H2 type// Src homology domain 2//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Src homology domain 2//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zin
  • BRACE20039540 //Immunoglobulin domain// Adenovirus E3 region protein CR2
  • BRACE20053280//PDZ domain Also known as DHR or GLGF.
  • BRACE20060890//Zinc finger C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BRACE20068590//KRAB box// Zinc finger C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type/
  • BRACE20223330 /3′-5′ exonuclease// Adenylylsulfate kinase// Protein of unknown function DUF82.
  • BRACE20253330//PDZ domain Also known as DHR or GLGF.
  • BRAMY20148130//WD domain G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// TBC domain
  • BRAMY20174550//ABC transporter transmembrane region // Phosphoribulokinase// Adenylylsulfate kinase// FtsK/SpoIIIE family// ABC transporter
  • BRAMY20260910//Zinc finger C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BRAMY20270730//Zinc finger C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C3HC4 type (RING finger)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type/ TNF (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2
  • BRAWH20064050 //Sushi domain (SCR repeat)// EGF-like domain// Trypsin Inhibitor like cysteine rich domain// EGF-like domain// Granulins// Granulins// EGF-like domain
  • BRAWH20075700//Zinc finger C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BRAWH20096780//KRAB box// Zinc finger C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type/
  • BRAWH20103290//CRAL/TR10 domain Spectrin repeat// Extracellular link domain// RhoGEF domain// PH domain
  • BRAWH20132190//Acetyltransferase (GNAT) family BRAWH20132190//Acetyltransferase (GNAT) family
  • G-beta repeat// WD domain G-beta repeat// WD domain
  • G-beta repeat// WD domain G-beta repeat// WD domain
  • G-beta repeat// WD domain G-beta repeat// WD domain
  • G-beta repeat// WD domain G-beta repeat// WD domain
  • G-beta repeat// WD domain G-beta repeat/// WD domain, G-beta repeat/// WD domain, G-beta repeat// WD domain, G-beta repeat/// WD domain, G-beta repeat/// WD domain, G-beta repeat/// WD domain, G-beta repeat/// WD domain, G-beta repeat/// WD domain, G-beta repeat/// WD domain, G-beta repeat/// WD domain, G-beta repeat/// WD domain, G-beta
  • BRCAN20280210//Zinc finger C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BRCOC20178270//Zinc finger C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BRHIP20119330//KRAB box// Zinc finger C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)/// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger,
  • BRHIP20132860//PDZ domain Also known as DHR or GLGF.
  • BRHIP20153600//RNA recognition motif (a.k.a. RRM, RBD, or
  • BRHIP20176420//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
  • BRHIP20207990 //Phorbol esters/diacylglycerol binding dom// Zinc finger, C3HC4 type (RING finger)// PHD-finger
  • BRHIP20222280//Zinc finger C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type/
  • BRHIP20238600//WD domain G-beta repeat// WD domain
  • G-beta repeat// WD domain G-beta repeat// WD domain
  • G-beta repeat// WD domain G-beta repeat// WD domain
  • G-beta repeat// WD domain G-beta repeat// WD domain
  • BRHIP30004880 //Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Fibronectin type III domain// Fibronectin type III domain
  • BRSSN20038200 //Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif// Initiator RepB protein// RasGEF domain
  • BRSSN20039370//KRAB box// Zinc finger C2H2 type// Zinc finger, C2H2 type
  • BRSSN20046790//Zinc finger C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type
  • CTONG20014280//WD domain G-beta repeat/// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat/// WD domain, G-beta repeat/// WD domain, G-beta repeat/// WD domain, G-beta repeat/// WD domain, G-beta repeat/// WD domain, G-beta repeat/// WD domain, G-beta repeat
  • CTONG20050280//KRAB box// Zinc finger C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger
  • CTONG20085950//SCAN domain// Zinc finger C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • CTONG20093950//Zinc finger C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • CTONG20118150//WD domain G-beta repeat/// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat/// WD domain, G-beta repeat/// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-
  • CTONG20121010//Zinc finger C2H2 type// CONSTANS family zinc finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger,
  • CTONG20124010//WD domain G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat
  • CTONG20131560//PDZ domain Also known as DHR or GLGF.
  • CTONG20133390//Zinc finger C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C3HC4 type (RING finger)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C3HC4 type (RING finger)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger,
  • CTONG20133520//KRAB box// Zinc finger C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type/
  • CTONG20140580//Domain of unknown function DUF25//SNF2 and others N-terminal domain// SNF2 and others N-terminal domain// Small cytokines (intecrine/chemokine), inter
  • CTONG20153580//F-box domain CTONG20153580//F-box domain.// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat
  • CTONG20156780//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
  • D9OST20033970//KRAB box// Zinc finger C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Putative zinc finger in N-recognin// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C
  • FCBBF10001150 //Cadherin domain// Cadherin domain// Cadherin domain// Cadherin domain// Cadherin domain// Cadherin domain// Cadherin domain
  • FCBBF10001550 //Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
  • FCBBF10001710//DM DNA binding domain// Zinc finger C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type/
  • FCBBF10002800 //Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • FCBBF10003770//PDZ domain Also known as DHR or GLGF.// PDZ domain (Also known as DHR or GLGF).// pf kB family carbohydrate kinase// PDZ domain (Also known as DHR or GLGF).// ThiC family// PDZ domain (Also known as DHR or GLGF).// PDZ domain (Also known as DHR or GLGF).// PDZ domain (Also known as DHR or GLGF).// PDZ domain (Also known as DHR or GLGF).// TIR domain
  • FCBBF10004120//RNA recognition motif (a.k.a. RRM, RBD, or
  • FCBBF10004370//KRAB box// Zinc finger C2H2 type// Ribosomal protein L37e// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type/
  • FCBBF10005060//CRAL/TRIO domain FCBBF10005060//CRAL/TRIO domain.
  • FCBBF10005460 //Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Fibronectin type III domain// Fibronectin type III domain
  • FCBBF10005500//Keratin high sulfur B2 protein
  • FCBBF20059090//Zinc finger C2H2 type
  • FCBBF20064520//RNA recognition motif (a.k.a. RRM, RBD, or
  • FCBBF20067810 //Nerve growth factor family// GTP1/OBG family// GTP1/OBG family// GTPase of unknown function// ADP-ribosylation factor family// Ras family
  • FCBBF20068820//Zinc finger C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • FCBBF30016320//SecA protein amino terminal region

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Abstract

Novel full-length cDNAs are provided. 2443 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.

Description

    FIELD OF THE INVENTION
  • The present invention relates to polynucleotides encoding novel polypeptides, polypeptides encoded by the polynucleotides, and new uses of these.
    • BACKGROUND OF THE INVENTION
  • Currently, the sequencing projects, the determination and analysis of the genomic DNA of various living organisms have been in progress all over the world. The whole genomic sequences of more than 40 species of prokaryotes, a lower eukaryote, yeast, a multicellular eukaryote, C. elegans, and a higher plants, arabidopsis, etc. are already determined. For human genome, presumably having 3 billion base pairs, the analysis was advanced under global cooperative organization, and a draft sequence was disclosed in 2001. Moreover, all the structures are to be clear and to be disclosed in 2002-2003. The aim of the determination of genomic sequence is to reveal the functions of all genes and their regulation and to understand living organisms as a network of interactions between genes, proteins, cells or individuals through deducing the information in a genome, which is a blueprint of the highly complicated living organisms. To understand living organisms by utilizing the genomic information from various species is not only important as an academic subject, but also socially significant from the viewpoint of industrial application.
  • However, determination of genomic sequences itself cannot identify the functions of all genes. For example, as for yeast, only the function of approximately half of the 6000 genes, which is predicted based on the genomic sequence, was able to be deduced. On the other hand, the human genome has been estimated to contain about 30,000-40,000 genes. Further, 100,000 or more types of mRNAs are said to exist when variants produced by alternative splicing are taken into consideration. Therefore, it is desirable to establish “a high throughput analysis system of the gene functions” which allows us to identify rapidly and efficiently the functions of vast amounts of the genes obtained by the genomic sequencing.
  • Many genes in the eukaryotic genome are split by introns into multiple exons. Thus, it is difficult to predict correctly the structure of encoded protein solely based on genomic information. In contrast, cDNA, which is produced from mRNA that lacks introns, encodes a protein as a single continuous amino acid sequence and allows us to identify the primary structure of the protein easily. In human cDNA research, to date, more than three million ESTs (Expression Sequence Tags) are publicly available, and the ESTs presumably cover not less than 80% of all human genes.
  • The information of ESTs is utilized for analyzing the structure of human genome, or for predicting the exon-regions of genomic sequences or their expression profile. However, many human ESTs have been derived from proximal regions to the 3′-end of cDNA, and information around the 5′-end of mRNA is extremely little. Among human cDNAs, the number of the corresponding mRNAs whose encoding full-length protein sequences are deduced is approximately 13,000.
  • It is possible to identify the transcription start site of mRNA on the genomic sequence based on the 5′-end sequence of a full-length cDNA, and to analyze factors involved in the stability of mRNA that is contained in the cDNA, or in its regulation of expression at the translation stage. Also, since a full-length cDNA contains atg codon, the translation start site, in the 5′-region, it can be translated into a protein in a correct frame. Therefore, it is possible to produce a large amount of the protein encoded by the cDNA or to analyze biological activity of the expressed protein by utilizing an appropriate expression system. Thus, analysis of a full-length cDNA provides valuable information which complements the information from genome sequencing. Also, full-length cDNA clones that can be expressed are extremely valuable in empirical analysis of gene function and in industrial application.
  • Therefore, if a novel human full-length cDNA is isolated, it can be used for developing medicines for diseases in which the gene is involved. The protein encoded by the gene can be used as a drug by itself. Thus, it has great significance to obtain a full-length cDNA encoding a novel human protein.
  • In particular, human secretory proteins or membrane proteins would be useful by itself as a medicine like tissue plasminogen activator (TPA), or as a target of medicines like membrane receptors. In addition, genes for signal transduction-related proteins (protein kinases, etc.), glycoprotein-related proteins, transcription-related proteins, etc. are genes whose relationships to human diseases have been elucidated. Moreover, genes for disease-related proteins form a gene group rich in genes whose relationships to human diseases have been elucidated.
  • Therefore, it has great significance to isolate novel full-length cDNA clones of human, only few of which has been isolated. Especially, isolation of a novel cDNA clone encoding a secretory protein or membrane protein is desired since the protein itself would be useful as a medicine, and also the clones potentially include a gene involved in diseases. In addition, genes encoding proteins that are involved in signal transduction, glycoprotein, transcription, or diseases are expected to be useful as target molecules for therapy, or as medicines themselves. These genes form a gene group predicted to be strongly involved in diseases. Thus, identification of the full-length cDNA clones encoding those proteins has great significance.
    • SUMMARY OF THE INVENTION
  • An objective of the present invention is to provide polynucleotides encoding novel polypeptides, polypeptides encoded by the polynucleotides, and novel usages of these.
  • The inventors have developed a method for efficiently cloning, from a cDNA library having very high fullness-ratio, a human full-length cDNA that is predicted to be a full-length cDNA clone, where the cDNA library is synthesized by an improved method (WO 01/04286) of the oligo-capping method (K. Maruyama and S. Sugano, Gene, 138: 171-174 (1994); Y. Suzuki et al., Gene, 200: 149-156 (1997)). Then, the nucleotide sequences of cDNA clones whose fullness ratio is high, obtained by this method, were determined mainly from their 5′-ends, and, if required, from 3′-ends.
  • Further, representative clones, which were estimated to be novel and full-length, among the clones obtained, were analyzed for their full-length nucleotide sequences. The determined full-length nucleotide sequences were analyzed by BLAST homology search of the databases shown below. Because the homology search of the present invention is carried out based on the information of full-length cDNAs including the entire coding regions, homology to every part of a polypeptide can be analyzed. Thus, in the present invention, the reliability of homology search has been greatly improved.
  • [1] SwissProt (http://www.ebi.ac.uk/ebi_docsSwissProt_db/swisshome.html),
  • [2] GenBank (http://www.ncbi.nlm.nih.gov/web/GenBank),
  • [3] UniGene (Human) (http://www.ncbi.nlm.nih.gov/UniGene), and
  • [4] nr (a protein database, which has been constructed by combining data of coding sequences (CDS) in nucleotide sequences deposited in GenBank, and data of SwissProt, PDB (http://www.rcsb.org/pdb/index.html), PIR (http://pir.georgetown.edu/pirwww/pirhome.shtml), and PRF (http://www.prf.or.jp/en/); overlapping sequences have been removed.)
  • Further, the gene expression profiles of cDNA clones whose full-length nucleotide sequence had been determined were studied by analyzing the large-scale cDNA database constructed based on the 5′-end nucleotide sequences of cDNAs obtained. In addition to the analysis for the expression profile by computer, the profiles of gene expression in living cells were also determined by PCR. The present inventors revealed the usefulness of the genes of the present invention based on these analysis results.
  • In the present invention, gene functions were revealed by the analysis of expression profiles in silico based on the information of full-length nucleotide sequences. The expression profiles used in the expression frequency analysis were studied based on the database containing sufficient amount of fragment sequence data. The expression frequency analysis was carried out by referring, for these expression profiles, to the full-length nucleotide sequences of many cDNA clones obtained in the present invention. Thus, a highly reliable analysis can be achieved by referring to the full-length nucleotide sequences of a wide variety of genes for the sufficiently large population for analysis (expression profiles). Namely, the results of expression frequency analysis using the full-length sequences of the present invention more precisely reflect the gene expression frequency in tissues and cells from which a certain cDNA library was derived. In other words, the information of full-length cDNA nucleotide sequence of the present invention made it possible to achieve the highly reliable expression frequency analysis.
  • The full-length cDNA clones of this invention were obtained by the method comprising the steps of [1] preparing libraries containing cDNAs with the high fullness ratio by oligo-capping, and [2] assembling 5′-end sequences and selecting one with the highest probability of completeness in length in the cluster formed (there are many clones longer in the 5′-end direction). However, the uses of primers designed based on the 5′- and 3′-end sequences of polynucleotides provided by the present invention enable readily obtaining full-length cDNAs without such a special technique. The primer, which is designed to be used for obtaining cDNAs capable of being expressed, is not limited to the 5′- and 3′-end sequences of polynucleotide.
  • Specifically, the present invention relates to a polynucleotide selected from the group consisting of the following (a) to (g):
  • (a) a polynucleotide comprising a protein-coding region of the nucleotide sequence of any one of SEQ ID NOs shown in Table 1;
  • (b) a polynucleotide encoding a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs shown in Table 1;
  • (c) a polynucleotide comprising a nucleotide sequence encoding a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs shown in Table 1, wherein, in said amino acid sequence, one or more amino acids have been substituted, deleted, inserted, and/or added, and wherein said nucleotide sequence encodes a polypeptide functionally equivalent to a polypeptide comprising the selected amino acid sequence;
  • (d) a polynucleotide hybridizing under stringent conditions to a polynucleotide comprising the nucleotide sequence of any one of SEQ ID NOs shown in Table 1, wherein said nucleotide sequence encodes a polypeptide functionally equivalent to a polypeptide encoded by the selected nucleotide sequence;
  • (e) a polynucleotide comprising a′ nucleotide sequence encoding a partial amino acid sequence of a polypeptide encoded by the polynucleotide according to any one of (a) to (d);
  • (f) a polynucleotide comprising a nucleotide sequence having at least 70% identity to the nucleotide sequence of (a); and
  • (g) a polynucleotide comprising a nucleotide sequence having at least 90% identity to the nucleotide sequence of (a).
  • The present invention also relates to a polypeptide encoded by the above-mentioned polynucleotide or a partial peptide thereof, an antibody binding to the polypeptide or the peptide, and a method for immunologically assaying the polypeptide or the peptide, which comprises the steps of contacting the polypeptide or the peptide with the antibody, and observing the binding between the two.
  • Furthermore, the present invention features a vector comprising the above-mentioned polynucleotide, a transformant carrying the polynucleotide or the vector, a transformant carrying the polynucleotide or the vector in an expressible manner, and a method for producing the polypeptide or the peptide, which comprises the steps of culturing the transformant and recovering an expression product.
  • Another feature of the present invention is an oligonucleotide comprising at least 15 nucleotides, said oligonucleotide comprising a nucleotide sequence complementary to the nucleotide sequence of any one of SEQ ID NOs: 1 to 2443 or to a complementary strand thereof. This oligonucleotide can be used as a primer for synthesizing the above-mentioned polynucleotide or used as a probe for detecting the polynucleotide. The present invention includes an antisense polynucleotide against the polynucleotide or a part thereof, and a method for detecting the polynucleotide, which comprises the following steps of:
  • a) incubating a target polynucleotide with the oligonucleotide under hybridizable conditions, and
  • b) detecting hybridization of the target polynucleotide with the oligonucleotide.
  • Still another feature of the present invention is database of polynucleotides and/or polypeptides, said database comprising information on at least one of the nucleotide sequences of SEQ ID NOs: 1 to 2443 and/or on at least one of the amino acid sequences of SEQ ID NOs: 2444 to 4886.
  • Herein, “polynucleotide” is defined as a molecule, such as DNA and RNA, in which multiple nucleotides are polymerized. There are no limitations on the number of the polymerized nucleotides. In case that the polymer contains relatively low number of nucleotides, it is also described as an “oligonucleotide”, which is included in the “polynucleotide” of the present invention. The polynucleotide or the oligonucleotide of the present invention can be a natural or chemically synthesized product. Alternatively, it can be synthesized using a template polynucleotide by an enzymatic reaction such as PCR. Furthermore, the polynucleotide of the present invention may be modified chemically. Moreover, not only a single-strand polynucleotide but also a double-strand polynucleotide is included in the present invention. In this specification, especially in claims, when the polynucleotide is described merely as “polynucleotide”, it means not only a single-strand polynucleotide but also a double-strand polynucleotide. When it means double-strand polynucleotide, the nucleotide sequence of only one chain is indicated. However, based on the nucleotide sequence of a sense chain, the nucleotide sequence of the complementary strand thereof is essentially determined.
  • As used herein, an “isolated polynucleotide” is a polynucleotide the structure of which is not identical to that of any naturally occurring polynucleotide or to that of any fragment of a naturally occurring genomic polynucleotide spanning more than three separate genes. The term therefore includes, for example, (a) a DNA which has the sequence of part of a naturally occurring genomic DNA molecule in the genome of the organism in which it naturally occurs; (b) a polynucleotide incorporated into a vector or into the genomic DNA of a prokaryote or eukaryote in a manner such that the resulting molecule is not identical to any naturally occurring vector or genomic DNA; (c) a separate molecule such as a cDNA, a genomic fragment, a fragment produced by polymerase chain reaction (PCR), or a restriction fragment; and (d) a recombinant nucleotide sequence that is part of a hybrid gene, i.e., a gene encoding a fusion polypeptide. Specifically excluded from this definition are polynucleotides of DNA molecules present in mixtures of different (i) DNA molecules, (ii) transfected cells, or (iii) cell clones; e.g., as these occur in a DNA library such as a cDNA or genomic DNA library.
  • The term “substantially pure” as used herein in reference to a given protein or polypeptide means that the protein or polypeptide is substantially free from other biological macromolecules. For example, the substantially pure protein or polypeptide is at least 75%, 80%, 85%, 95%, or 99% pure by dry weight. Purity can be measured by any appropriate standard method known in the art, for example, by column chromatography, polyacrylamide gel electrophoresis, or HPLC analysis.
  • All the cDNAs provided by the present invention are full-length cDNAs. The “full-length cDNA” herein means that the cDNA contains the ATG codon, which is the start point of translation therein. The untranslated regions upstream and downstream of the protein-coding region, both of which are naturally contained in natural mRNAs, are not indispensable. It is preferable that the full-length cDNAs of the present invention contain the stop codon.
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 shows the restriction map of the vector pME18SFL3.
    • DETAILED DESCRIPTION OF THE INVENTION
  • All the clones (2443 clones) of the present invention are novel and encode the full-length polypeptides. Further, all the clones are cDNAs with the high fullness ratio, which were obtained by oligo-capping method, and also clones which are not identical to any of known human mRNAs (namely, novel clones) selected by searching, for the 5′-end sequences, mRNA sequences with the annotation of “complete cds” in the GenBank and UniGene databases by using the BLAST homology search [S. F. Altschul, W. Gish, W. Miller, E. W. Myers & D. J. Lipman, J. Mol. Biol., 215: 403-410 (1990); W. Gish & D. J. States, Nature Genet., 3: 266-272 (1993)]; they are also clones that were assumed to have higher fullness ratio among the members in the cluster formed by assembling. Most of the clones assessed to have high fullness ratio in the cluster had the nucleotide sequences longer in the 5′-end direction.
  • All the full-length cDNAs of the present invention can be synthesized by a method such as PCR (Current protocols in Molecular Biology edit. Ausubel et al. (1987) Publish. John Wiley & Sons Section 6.1-6.4) using primer sets designed based on the 5′-end and 3′-end sequences or using primer sets of primers designed based on the 5′-end sequences and a primer of oligo dT sequence corresponding to poly A sequence. Table 1 contains the clone names of full-length cDNA of 2443 clones of the present invention, SEQ ID NOs of the full-length nucleotide sequences, CDS portions deduced from the full-length nucleotide sequences, and SEQ ID NOs of the translated amino acids. The positions of CDS are shown according to the rule of “DDBJ/EMBL/GenBank Feature Table Definition” (http://www.ncbi.nlm.nih.gov/collab/FT/index.html). The start position number corresponds to the first letter of “ATG” that is the nucleotide triplet encoding methionine; the termination position number corresponds to the third letter of the stop codon. These are indicated being flanked with the mark “..”. However, with respect to the clones having no stop codon, the termination position is indicated by the mark “>” according to the above rule.
    TABLE 1
    SEQ ID NO. SEQ ID NO.
    Clone of nucleotide Position of amino acid
    name sequence of CDS sequence
    3NB6910001910 1 30..1661 2444
    3NB6920014080 2 80..922 2445
    3NB6920014590 3 1..693 2446
    ADIPS10000640 4 127..1098 2447
    ADIPS20004250 5 170..2212 2448
    ADRGL10001470 6 368..829 2449
    ADRGL20000640 7 599..1345 2450
    ADRGL20011190 8 61..>2254 2451
    ADRGL20012870 9 827..1300 2452
    ADRGL20013010 10 1127..1444 2453
    ADRGL20013520 11 226..837 2454
    ADRGL20018300 12 320..2233 2455
    ADRGL20018540 13 55..363 2456
    ADRGL20028570 14 218..976 2457
    ADRGL20035850 15 55..522 2458
    ADRGL20044590 16 692..1042 2459
    ADRGL20048330 17 189..2204 2460
    ADRGL20061930 18 293..>1899 2461
    ADRGL20067670 19 108..512 2462
    ADRGL20068170 20 217..615 2463
    ADRGL20068460 21 576..1280 2464
    ADRGL20073570 22 556..891 2465
    ADRGL20076360 23 159..515 2466
    ADRGL20078100 24 418..1563 2467
    ADRGL20083310 25 871..1368 2468
    ASTRO10001650 26 369..2168 2469
    ASTRO20001410 27 319..744 2470
    ASTRO20005330 28 196..642 2471
    ASTRO20008010 29 735..1169 2472
    ASTRO20012490 30 286..783 2473
    ASTRO20027430 31 129..848 2474
    ASTRO20032120 32 860..1189 2475
    ASTRO20033160 33 139..1014 2476
    ASTRO20055750 34 16..2007 2477
    ASTRO20058630 35 28..957 2478
    ASTRO20064750 36 1381..>2654 2479
    ASTRO20072210 37 274..>1868 2480
    ASTRO20084250 38 35..1381 2481
    ASTRO20100720 39 394..714 2482
    ASTRO20105820 40 205..1368 2483
    ASTRO20106150 41 138..1811 2484
    ASTRO20108190 42 791..2539 2485
    ASTRO20111490 43 517..921 2486
    ASTRO20114370 44 145..1782 2487
    ASTRO20114610 45 53..433 2488
    ASTRO20125520 46 1674..2456 2489
    ASTRO20130500 47 15..2417 2490
    ASTRO20136710 48 319..657 2491
    ASTRO20138020 49 285..995 2492
    ASTRO20141350 50 394..1767 2493
    ASTRO20143630 51 103..1305 2494
    ASTRO20145760 52 347..2008 2495
    ASTRO20152140 53 760..1233 2496
    ASTRO20155290 54 208..2298 2497
    ASTRO20166810 55 7..381 2498
    ASTRO20168470 56 334..1329 2499
    ASTRO20173480 57 119..724 2500
    ASTRO20181690 58 84..1967 2501
    ASTRO20190390 59 2282..2662 2502
    BEAST20004540 60 1022..1513 2503
    BGGI110000240 61 123..1649 2504
    BGGI110001930 62 81..1307 2505
    BGGI120006160 63 6..680 2506
    BLADE20003400 64 17..1876 2507
    BLADE20003890 65 555..2405 2508
    BLADE20004630 66 58..405 2509
    BNGH420088500 67 2..1270 2510
    BRACE20003070 68 310..1563 2511
    BRACE20006400 69 32..364 2512
    BRACE20011070 70 21..1553 2513
    BRACE20019540 71 538..993 2514
    BRACE20027620 72 24..1289 2515
    BRACE20037660 73 143..469 2516
    BRACE20038000 74 646..2187 2517
    BRACE20038470 75 963..1307 2518
    BRACE20038480 76 1838..2626 2519
    BRACE20038850 77 1099..1413 2520
    BRACE20039040 78 1273..1671 2521
    BRACE20039440 79 216..797 2522
    BRACE20039540 80 1153..1905 2523
    BRACE20050900 81 115..1788 2524
    BRACE20051380 82 1433..1783 2525
    BRACE20051690 83 380..742 2526
    BRACE20052160 84 20..1024 2527
    BRACE20053280 85 736..1524 2528
    BRACE20053480 86 24..875 2529
    BRACE20053630 87 81..950 2530
    BRACE20054500 88 364..669 2531
    BRACE20055180 89 156..656 2532
    BRACE20056810 90 338..940 2533
    BRACE20057190 91 1016..1660 2534
    BRACE20057420 92 539..856 2535
    BRACE20057620 93 1226..1588 2536
    BRACE20057730 94 819..1592 2537
    BRACE20058580 95 146..1330 2538
    BRACE20058810 96 40..345 2539
    BRACE20059370 97 192..1574 2540
    BRACE20060550 98 197..1687 2541
    BRACE20060720 99 220..618 2542
    BRACE20060840 100 37..927 2543
    BRACE20060890 101 170..964 2544
    BRACE20061050 102 1130..1573 2545
    BRACE20061740 103 434..865 2546
    BRACE20062400 104 1310..1732 2547
    BRACE20062640 105 278..2089 2548
    BRACE20062740 106 753..1151 2549
    BRACE20063630 107 414..800 2550
    BRACE20063780 108 11..892 2551
    BRACE20063800 109 70..435 2552
    BRACE20063930 110 1795..2433 2553
    BRACE20064880 111 365..1420 2554
    BRACE20067430 112 875..1189 2555
    BRACE20068590 113 260..1759 2556
    BRACE20069090 114 1484..1960 2557
    BRACE20081720 115 1182..1565 2558
    BRACE20082950 116 1713..2018 2559
    BRACE20090440 117 58..444 2560
    BRACE20096200 118 168..1130 2561
    BRACE20096540 119 43..729 2562
    BRACE20097320 120 51..509 2563
    BRACE20099570 121 3..425 2564
    BRACE20101700 122 579..968 2565
    BRACE20101710 123 187..681 2566
    BRACE20106690 124 335..691 2567
    BRACE20106840 125 19..402 2568
    BRACE20107530 126 437..1063 2569
    BRACE20108130 127 927..1229 2570
    BRACE20108880 128 417..782 2571
    BRACE20109370 129 1197..1778 2572
    BRACE20109830 130 747..1382 2573
    BRACE20111830 131 366..737 2574
    BRACE20114780 132 515..886 2575
    BRACE20115450 133 399..764 2576
    BRACE20115920 134 41..937 2577
    BRACE20116110 135 830..1150 2578
    BRACE20116460 136 84..509 2579
    BRACE20118380 137 657..1421 2580
    BRACE20121850 138 474..857 2581
    BRACE20136240 139 111..518 2582
    BRACE20141080 140 148..534 2583
    BRACE20142320 141 164..499 2584
    BRACE20142570 142 591..926 2585
    BRACE20147800 143 133..513 2586
    BRACE20148210 144 1101..1541 2587
    BRACE20148240 145 713..2128 2588
    BRACE20150310 146 94..408 2589
    BRACE20151320 147 137..1189 2590
    BRACE20152870 148 207..653 2591
    BRACE20153680 149 87..956 2592
    BRACE20154120 150 351..989 2593
    BRACE20163150 151 699..1085 2594
    BRACE20163350 152 443..1597 2595
    BRACE20165830 153 401..709 2596
    BRACE20171240 154 62..439 2597
    BRACE20172980 155 20..445 2598
    BRACE20175870 156 67..396 2599
    BRACE20177200 157 1178..1675 2600
    BRACE20179340 158 47..1171 2601
    BRACE20185680 159 880..1341 2602
    BRACE20188470 160 1247..2926 2603
    BRACE20190040 161 6..464 2604
    BRACE20190440 162 382..1287 2605
    BRACE20192440 163 1199..2062 2606
    BRACE20195100 164 251..736 2607
    BRACE20201570 165 661..1056 2608
    BRACE20210140 166 248..550 2609
    BRACE20220300 167 1057..1392 2610
    BRACE20223280 168 6..1976 2611
    BRACE20223330 169 97..2373 2612
    BRACE20224480 170 1568..1924 2613
    BRACE20224500 171 1674..2081 2614
    BRACE20228480 172 1268..2176 2615
    BRACE20229280 173 239..700 2616
    BRACE20230700 174 354..752 2617
    BRACE20232840 175 79..2019 2618
    BRACE20235400 176 213..593 2619
    BRACE20237270 177 3..494 2620
    BRACE20238000 178 135..437 2621
    BRACE20240740 179 83..1546 2622
    BRACE20248260 180 682..1533 2623
    BRACE20253160 181 26..559 2624
    BRACE20253330 182 220..1041 2625
    BRACE20257100 183 1638..2021 2626
    BRACE20262930 184 256..681 2627
    BRACE20262940 185 259..591 2628
    BRACE20266750 186 58..1143 2629
    BRACE20267250 187 139..612 2630
    BRACE20269200 188 4..408 2631
    BRACE20269710 189 338.1063 2632
    BRACE20273890 190 1365..1766 2633
    BRACE20274080 191 350..655 2634
    BRACE20276430 192 232..>2028 2635
    BRACE20283920 193 717..1025 2636
    BRACE20284100 194 1026..1865 2637
    BRACE20286360 195 170..727 2638
    BRACE20287410 196 603..956 2639
    BRALZ20013500 197 215..640 2640
    BRALZ20014450 198 6..374 2641
    BRALZ20017430 199 232..747 2642
    BRALZ20018340 200 879..1481 2643
    BRALZ20019660 201 180..773 2644
    BRALZ20054710 202 135..1223 2645
    BRALZ20058880 203 102..1607 2646
    BRALZ20059500 204 722..1081 2647
    BRALZ20064740 205 24..350 2648
    BRALZ20065600 206 25..624 2649
    BRALZ20069760 207 14..319 2650
    BRALZ20073760 208 576..1124 2651
    BRALZ20075450 209 775..1200 2652
    BRALZ20075760 210 148..726 2653
    BRALZ20077900 211 1900..2529 2654
    BRALZ20077930 212 50..2077 2655
    BRALZ20080310 213 1304..2005 2656
    BRALZ20088690 214 104..661 2657
    BRAMY10001300 215 2352..2795 2658
    BRAMY20001570 216 696..1604 2659
    BRAMY20000520 217 329..1204 2660
    BRAMY20000860 218 246..548 2661
    BRAMY20002770 219 76..447 2662
    BRAMY20004110 220 145..540 2663
    BRAMY20011140 221 2661..3011 2664
    BRAMY20025840 222 1058..2002 2665
    BRAMY20039260 223 101..424 2666
    BRAMY20045240 224 662..1792 2667
    BRAMY20054880 225 508..981 2668
    BRAMY20060920 226 110..439 2669
    BRAMY20063970 227 246..551 2670
    BRAMY20071850 228 178..705 2671
    BRAMY20102080 229 513..1136 2672
    BRAMY20103570 230 114..1001 2673
    BRAMY20104640 231 334..1410 2674
    BRAMY20110640 232 1400.1735 2675
    BRAMY20111960 233 534..854 2676
    BRAMY20112800 234 31..606 2677
    BRAMY20116790 235 2348..2794 2678
    BRAMY20120910 236 182..976 2679
    BRAMY20121190 237 81..398 2680
    BRAMY20121620 238 51..1688 2681
    BRAMY20124260 239 95..1759 2682
    BRAMY20134140 240 1..510 2683
    BRAMY20135900 241 4..1053 2684
    BRAMY20136210 242 1810..2145 2685
    BRAMY20137560 243 2220..2795 2686
    BRAMY20144620 244 892..1326 2687
    BRAMY20147540 245 147..611 2688
    BRAMY20148130 246 204..2138 2689
    BRAMY20152110 247 1257..1580 2690
    BRAMY20153110 248 11..763 2691
    BRAMY20157820 249 94..1740 2692
    BRAMY20160700 250 1686..2015 2693
    BRAMY20162510 251 186..1757 2694
    BRAMY20163250 252 96..719 2695
    BRAMY20163270 253 531..1010 2696
    BRAMY20167060 254 347..865 2697
    BRAMY20167710 255 900..1532 2698
    BRAMY20168920 256 91..1275 2699
    BRAMY20170140 257 115..681 2700
    BRAMY20174550 258 74..2179 2701
    BRAMY20178640 259 226..2025 2702
    BRAMY20181220 260 678..980 2703
    BRAMY20182730 261 208..738 2704
    BRAMY20183080 262 213..653 2705
    BRAMY20184670 263 871..1548 2706
    BRAMY20195090 264 2087..2476 2707
    BRAMY20196000 265 50..439 2708
    BRAMY20204450 266 34..462 2709
    BRAMY20205740 267 177..554 2710
    BRAMY20210400 268 131..703 2711
    BRAMY20211390 269 1407..2303 2712
    BRAMY20211420 270 131..2407 2713
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    BRAMY20215230 272 207..515 2715
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    BRAMY20218250 274 161..2167 2717
    BRAMY20218670 275 338..652 2718
    BRAMY20229800 276 1270..1662 2719
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    BRAMY20230600 278 614..1840 2721
    BRAMY20231720 279 429..773 2722
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    BRAMY20270730 295 124..2118 2738
    BRAMY20271400 296 177..>3011 2739
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    BRAWH10000930 305 843..1454 2748
    BRAWH20002320 306 162..716 2749
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    BRAWH20103180 327 1081..1659 2770
    BRAWH20103290 328 71..2626 2771
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    BRCAN20060190 370 206..595 2813
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    BRCOC10000870 396 186..602 2839
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    BRCOC20006370 400 21..455 2843
    BRCOC20008160 401 166..>2490 2844
    BRCOC20008500 402 151..>2854 2845
    BRCOC20020850 403 1371..1820 2846
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    BRCOC20035130 411 171..527 2854
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    BRCOC20037400 413 152..493 2856
    BRCOC20041750 414 230..535 2857
    BRCOC20055420 415 99..1556 2858
    BRCOC20059510 416 199..582 2859
    BRCOC20074760 417 10..>1918 2860
    BRCOC20077690 418 867..1202 2861
    BRCOC20078640 419 849..1208 2862
    BRCOC20090520 420 1157..1663 2863
    BRCOC20091960 421 1371..1895 2864
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    BRCOC20099370 423 1..1890 2866
    BRCOC20101230 424 94..810 2867
    BRCOC20105100 425 2393..2716 2868
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    BRCOC20110100 427 369..713 2870
    BRCOC20114180 428 167..487 2871
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    BRCOC20119960 430 147..500 2873
    BRCOC20121720 431 26..2983 2874
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    BRCOC20134480 434 587..1060 2877
    BRCOC20135730 435 1603..2064 2878
    BRCOC20136750 436 2876..3229 2879
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    OCBBF20180120 1419 218..1780 3862
    OCBBF20180840 1420 1169..1540 3863
    OCBBF20186870 1421 1278..1736 3864
    OCBBF20188730 1422 320..766 3865
    OCBBF20189560 1423 1512..2165 3866
    PANCR10000910 1424 1219..>1943 3867
    PEBLM10000240 1425 306..674 3868
    PEBLM10000710 1426 1719..1940 3869
    PEBLM20013120 1427 26..952 3870
    PEBLM20024320 1428 612..1406 3871
    PEBLM20024550 1429 1179..1499 3872
    PEBLM20040150 1430 1731..2165 3873
    PEBLM20042900 1431 226..>2439 3874
    PEBLM20044520 1432 922..1974 3875
    PEBLM20052820 1433 411..782 3876
    PEBLM20060310 1434 1731..>2083 3877
    PEBLM20060360 1435 58..330 3878
    PEBLM20060490 1436 431..892 3879
    PEBLM20071880 1437 497..814 3880
    PEBLM20072960 1438 128..1093 3881
    PEBLM20074370 1439 60..458 3882
    PEBLM20075980 1440 53..1153 3883
    PEBLM20078320 1441 5..1672 3884
    PEBLM20085760 1442 122..763 3885
    PERIC10000250 1443 689..1516 3886
    PERIC20002140 1444 151..1239 3887
    PERIC20003860 1445 33..359 3888
    PERIC20003870 1446 40..2817 3889
    PERIC20004220 1447 130..1935 3890
    PERIC20004780 1448 132..956 3891
    PLACE50000660 1449 329..2527 3892
    PLACE60003480 1450 35..877 3893
    PLACE60004630 1451 216..533 3894
    PLACE60060420 1452 34..246 3895
    PLACE60079250 1453 336..>3307 3896
    PLACE60086400 1454 279..764 3897
    PLACE60119750 1455 28..570 3898
    PLACE60121080 1456 769..1182 3899
    PLACE60136500 1457 1900..2241 3900
    PLACE60136720 1458 78..2519 3901
    PLACE60138830 1459 750..1202 3902
    PLACE60153220 1460 247..561 3903
    PLACE60155130 1461 833..1171 3904
    PLACE60161600 1462 77..1099 3905
    PLACE60169420 1463 165..1097 3906
    PLACE60177140 1464 1321..2190 3907
    PLACE60181070 1465 1355..1708 3908
    PLACE60187690 1466 1606..1941 3909
    PLACE60188340 1467 430..1224 3910
    PROST10003220 1468 187..933 3911
    PROST10004800 1469 87..419 3912
    PROST20005050 1470 673..1164 3913
    PROST20005670 1471 1132..>2293 3914
    PROST20021010 1472 612..926 3915
    PROST20024890 1473 14..514 3916
    PROST20029270 1474 1016..1363 3917
    PROST20047270 1475 1300..2250 3918
    PROST20047390 1476 163..2283 3919
    PROST20050670 1477 1622..2074 3920
    PROST20052280 1478 326..634 3921
    PROST20057930 1479 237..>2116 3922
    PROST20059040 1480 1047..1355 3923
    PROST20066880 1481 1937..2521 3924
    PROST20079500 1482 863..1957 3925
    PROST20083600 1483 209..1087 3926
    PROST20087700 1484 481..1287 3927
    PROST20097950 1485 91..405 3928
    PROST20100460 1486 63..1796 3929
    PROST20104000 1487 1059..2012 3930
    PROST20107820 1488 304..1524 3931
    PROST20111050 1489 772..1281 3932
    PROST20112970 1490 66..671 3933
    PROST20114390 1491 1291..1749 3934
    PROST20116600 1492 4..339 3935
    PROST20120050 1493 176..589 3936
    PROST20120160 1494 283..597 3937
    PROST20121900 1495 68..385 3938
    PROST20123530 1496 1619..2044 3939
    PROST20127400 1497 1156..1524 3940
    PROST20127800 1498 942..2120 3941
    PROST20130530 1499 416..1588 3942
    PROST20132600 1500 1447..2040 3943
    PROST20133270 1501 2..529 3944
    PROST20144220 1502 1011..1367 3945
    PROST20146010 1503 298..1953 3946
    PROST20149160 1504 1677..1991 3947
    PROST20149250 1505 635..1201 3948
    PROST20151240 1506 300..938 3949
    PROST20152460 1507 1542..2084 3950
    PROST20153320 1508 184..540 3951
    PROST20159240 1509 286..612 3952
    PROST20161950 1510 90..716 3953
    PROST20164440 1511 2570..3004 3954
    PROST20166680 1512 53..874 3955
    PROST20168290 1513 1757..2143 3956
    PROST20169800 1514 168..1763 3957
    PROST20170980 1515 28..1245 3958
    PROST20171280 1516 306..1493 3959
    PROST20175290 1517 1538..2323 3960
    PROST20176170 1518 998..2053 3961
    PROST20178360 1519 72..566 3962
    PROST20185830 1520 1200..2015 3963
    PROST20189770 1521 219..2018 3964
    PROST20191640 1522 318..1229 3965
    PUAEN10000850 1523 121..2040 3966
    PUAEN20003740 1524 104..409 3967
    PUAEN20011880 1525 28..2028 3968
    PUAEN20015260 1526 141..881 3969
    PUAEN20015860 1527 71..1846 3970
    PUAEN20018820 1528 41..1870 3971
    PUAEN20025680 1529 667..1584 3972
    PUAEN20027580 1530 36..512 3973
    PUAEN20030180 1531 127..978 3974
    PUAEN20040670 1532 326..2644 3975
    PUAEN20044000 1533 541..957 3976
    PUAEN20045110 1534 335..886 3977
    PUAEN20045250 1535 335..1054 3978
    PUAEN20051100 1536 228..1319 3979
    PUAEN20052470 1537 1699..2046 3980
    PUAEN20055020 1538 295..2553 3981
    PUAEN20078980 1539 6..989 3982
    PUAEN20081230 1540 62..469 3983
    PUAEN20083140 1541 104..1687 3984
    PUAEN20085150 1542 167..502 3985
    PUAEN20108240 1543 2..1993 3986
    RECTM10001410 1544 426..1631 3987
    RECTM20003490 1545 876..1193 3988
    RECTM20005100 1546 149..1273 3989
    SALGL10001710 1547 271..1722 3990
    SKMUS20001980 1548 75..1034 3991
    SKMUS20003610 1549 86..910 3992
    SKMUS20007010 1550 24..977 3993
    SKMUS20007800 1551 708..>1835 3994
    SKMUS20011640 1552 16..408 3995
    SKMUS20012010 1553 300..1019 3996
    SKMUS20016220 1554 80..1267 3997
    SKMUS20018230 1555 98..442 3998
    SKMUS20018500 1556 273..1172 3999
    SKMUS20020840 1557 79..1014 4000
    SKMUS20021530 1558 432..2135 4001
    SKMUS20024750 1559 201..1208 4002
    SKMUS20028210 1560 358..753 4003
    SKMUS20028400 1561 18..644 4004
    SKMUS20029200 1562 174..1130 4005
    SKMUS20031680 1563 171..485 4006
    SKMUS20046670 1564 234..617 4007
    SKMUS20048970 1565 104..1132 4008
    SKMUS20049030 1566 191..1096 4009
    SKMUS20077400 1567 170..772 4010
    SKMUS20084740 1568 83..>1516 4011
    SKNMC20006220 1569 1176..1856 4012
    SKNSH20008190 1570 490..2289 4013
    SKNSH20020540 1571 2184..2924 4014
    SKNSH20028660 1572 192..581 4015
    SKNSH20031740 1573 120..563 4016
    SKNSH20034660 1574 562..996 4017
    SKNSH20051940 1575 1006..1488 4018
    SKNSH20062340 1576 85..453 4019
    SKNSH20063040 1577 91..768 4020
    SKNSH20080430 1578 81..524 4021
    SKNSH20087770 1579 107..>1808 4022
    SKNSH20089400 1580 34..1092 4023
    SKNSH20091970 1581 181..489 4024
    SMINT20001760 1582 267..1706 4025
    SMINT20005410 1583 138..557 4026
    SMINT20008240 1584 1123..1500 4027
    SMINT20009840 1585 31..750 4028
    SMINT20011140 1586 1254..1664 4029
    SMINT20011580 1587 131..811 4030
    SMINT20011990 1588 132..512 4031
    SMINT20013480 1589 87..686 4032
    SMINT20014580 1590 57..410 4033
    SMINT20015590 1591 1375..1818 4034
    SMINT20022020 1592 133..726 4035
    SMINT20023280 1593 890..1345 4036
    SMINT20024570 1594 1852..2370 4037
    SMINT20026890 1595 541..2790 4038
    SMINT20028820 1596 1240..1749 4039
    SMINT20029760 1597 236..1282 4040
    SMINT20033170 1598 539..931 4041
    SMINT20033400 1599 20..778 4042
    SMINT20035690 1600 11..1411 4043
    SMINT20040860 1601 39..1169 4044
    SMINT20042990 1602 397..750 4045
    SMINT20047810 1603 109..588 4046
    SMINT20049090 1604 99..641 4047
    SMINT20050750 1605 101..907 4048
    SMINT20051610 1606 56..1513 4049
    SMINT20053300 1607 1251..1598 4050
    SMINT20053870 1608 85..894 4051
    SMINT20056210 1609 356..754 4052
    SMINT20058000 1610 200..565 4053
    SMINT20060780 1611 18..554 4054
    SMINT20065960 1612 859..1314 4055
    SMINT20068010 1613 136..1026 4056
    SMINT20071400 1614 212..1183 4057
    SMINT20073650 1615 59..1549 4058
    SMINT20076470 1616 1678..1983 4059
    SMINT20080540 1617 1280..1606 4060
    SMINT20089170 1618 54..530 4061
    SMINT20092330 1619 169..858 4062
    SMINT20092720 1620 1640..2293 4063
    SMINT20095050 1621 733..1107 4064
    SMINT20098320 1622 112..465 4065
    SMINT20100680 1623 237..614 4066
    SMINT20101440 1624 187..2109 4067
    SMINT20102780 1625 26..1642 4068
    SMINT20103690 1626 208..960 4069
    SMINT20105000 1627 194..514 4070
    SMINT20105330 1628 1580..2020 4071
    SMINT20106290 1629 501..1802 4072
    SMINT20106720 1630 80..1498 4073
    SMINT20108530 1631 185..523 4074
    SMINT20109970 1632 1444..>1974 4075
    SMINT20110330 1633 1398..2222 4076
    SMINT20110660 1634 1108..1500 4077
    SMINT20112730 1635 80..1564 4078
    SMINT20115880 1636 679..1746 4079
    SMINT20121220 1637 263..>1798 4080
    SMINT20121950 1638 6..443 4081
    SMINT20122850 1639 454..777 4082
    SMINT20122910 1640 1516..2094 4083
    SMINT20127350 1641 622..1449 4084
    SMINT20127930 1642 67..1554 4085
    SMINT20130320 1643 178..2601 4086
    SMINT20131810 1644 583..1257 4087
    SMINT20132280 1645 293..655 4088
    SMINT20136130 1646 1291..1752 4089
    SMINT20138900 1647 87..1439 4090
    SMINT20144430 1648 54..647 4091
    SMINT20144800 1649 171..1394 4092
    SMINT20144890 1650 209..520 4093
    SMINT20152940 1651 386..985 4094
    SMINT20153260 1652 135..1838 4095
    SMINT20153530 1653 1186..1524 4096
    SMINT20154540 1654 107..1339 4097
    SMINT20155180 1655 20..763 4098
    SMINT20157450 1656 669..1118 4099
    SMINT20158100 1657 30..587 4100
    SMINT20161220 1658 397..1977 4101
    SMINT20162860 1659 36..494 4102
    SMINT20163960 1660 665..1036 4103
    SMINT20164400 1661 125..706 4104
    SMINT20164770 1662 529..870 4105
    SMINT20168570 1663 1593..2069 4106
    SMINT20173190 1664 251..829 4107
    SMINT20173240 1665 253..582 4108
    SMINT20174360 1666 978..1733 4109
    SMINT20177360 1667 172..771 4110
    SMINT20178550 1668 51..692 4111
    SMINT20179740 1669 78..1865 4112
    SMINT20183530 1670 1130..2530 4113
    SMINT20190170 1671 80..1567 4114
    SMINT20191420 1672 49..1365 4115
    SMINT20191530 1673 40..2040 4116
    SMINT20192000 1674 49..435 4117
    SPLEN10000830 1675 1586..2053 4118
    SPLEN20000640 1676 27..755 4119
    SPLEN20002220 1677 87..434 4120
    SPLEN20003070 1678 684..1046 4121
    SPLEN20006070 1679 78..2837 4122
    SPLEN20008390 1680 375..2378 4123
    SPLEN20008740 1681 66..1547 4124
    SPLEN20008820 1682 31..1872 4125
    SPLEN20011410 1683 199..2394 4126
    SPLEN20013540 1684 978..1310 4127
    SPLEN20016260 1685 906..1748 4128
    SPLEN20019450 1686 180..680 4129
    SPLEN20020070 1687 65..451 4130
    SPLEN20021660 1688 130..771 4131
    SPLEN20022230 1689 133..1026 4132
    SPLEN20023140 1690 1153..1605 4133
    SPLEN20026950 1691 855..3383 4134
    SPLEN20027440 1692 29..2488 4135
    SPLEN20029310 1693 70..585 4136
    SPLEN20031600 1694 1658..2083 4137
    SPLEN20032040 1695 357..746 4138
    SPLEN20032190 1696 441..785 4139
    SPLEN20033960 1697 16..1026 4140
    SPLEN20039240 1698 1177..1929 4141
    SPLEN20040600 1699 60..368 4142
    SPLEN20054290 1700 187..2421 4143
    SPLEN20076530 1701 254..586 4144
    SPLEN20077500 1702 79..1941 4145
    SPLEN20079260 1703 535..1506 4146
    SPLEN20079510 1704 1880..>2197 4147
    SPLEN20084600 1705 13..1878 4148
    SPLEN20095410 1706 816..1541 4149
    SPLEN20095550 1707 193..>2558 4150
    SPLEN20095810 1708 248..670 4151
    SPLEN20097330 1709 1448..1849 4152
    SPLEN20099700 1710 91..>3025 4153
    SPLEN20101190 1711 1864..2250 4154
    SPLEN20103950 1712 25..507 4155
    SPLEN20106250 1713 295..711 4156
    SPLEN20117660 1714 662..1099 4157
    SPLEN20118300 1715 332..1486 4158
    SPLEN20119810 1716 526..1644 4159
    SPLEN20121750 1717 464..1021 4160
    SPLEN20126190 1718 274..2688 4161
    SPLEN20128000 1719 96..1664 4162
    SPLEN20129610 1720 207..557 4163
    SPLEN20140800 1721 387..2144 4164
    SPLEN20141360 1722 491..799 4165
    SPLEN20141990 1723 443..745 4166
    SPLEN20142100 1724 301..996 4167
    SPLEN20143180 1725 50..448 4168
    SPLEN20144520 1726 2002..2463 4169
    SPLEN20145720 1727 1205..>1939 4170
    SPLEN20146450 1728 362..862 4171
    SPLEN20146690 1729 1966..2550 4172
    SPLEN20147110 1730 313..2067 4173
    SPLEN20147390 1731 169..1479 4174
    SPLEN20149110 1732 2..769 4175
    SPLEN20149190 1733 26..364 4176
    SPLEN20149240 1734 787..2490 4177
    SPLEN20150940 1735 79..2385 4178
    SPLEN20151210 1736 66..1715 4179
    SPLEN20152610 1737 986..1453 4180
    SPLEN20152760 1738 284..628 4181
    SPLEN20157300 1739 426..728 4182
    SPLEN20157880 1740 35..769 4183
    SPLEN20158900 1741 1643..2032 4184
    SPLEN20158990 1742 843..1172 4185
    SPLEN20160450 1743 552..1115 4186
    SPLEN20160690 1744 734..1099 4187
    SPLEN20160980 1745 124..456 4188
    SPLEN20162680 1746 646..2007 4189
    SPLEN20163560 1747 86..2173 4190
    SPLEN20165310 1748 80..1492 4191
    SPLEN20166270 1749 1134..1814 4192
    SPLEN20167200 1750 223..570 4193
    SPLEN20169220 1751 160..576 4194
    SPLEN20169720 1752 72..2492 4195
    SPLEN20170310 1753 125..1039 4196
    SPLEN20171210 1754 7..837 4197
    SPLEN20171470 1755 41..2272 4198
    SPLEN20171890 1756 1312..1716 4199
    SPLEN20172120 1757 138..500 4200
    SPLEN20173510 1758 235..1785 4201
    SPLEN20174260 1759 99..428 4202
    SPLEN20176200 1760 36..431 4203
    SPLEN20179180 1761 173..1201 4204
    SPLEN20179810 1762 1374..3224 4205
    SPLEN20181810 1763 641..1183 4206
    SPLEN20186430 1764 80..979 4207
    SPLEN20193110 1765 1744..2118 4208
    SPLEN20194050 1766 1351..2331 4209
    SPLEN20198110 1767 1260..1562 4210
    SPLEN20204170 1768 202..594 4211
    SPLEN20211220 1769 601..1500 4212
    SPLEN20211570 1770 174..521 4213
    SPLEN20211940 1771 241..1155 4214
    SPLEN20212730 1772 979..1830 4215
    SPLEN20212950 1773 283..2055 4216
    SPLEN20213830 1774 137..460 4217
    SPLEN20214400 1775 28..387 4218
    SPLEN20214580 1776 300..602 4219
    SPLEN20222270 1777 241..927 4220
    SPLEN20225220 1778 672..1199 4221
    SPLEN20242320 1779 136..522 4222
    SPLEN20242730 1780 2343..2732 4223
    SPLEN20243830 1781 197..556 4224
    SPLEN20245300 1782 945..1529 4225
    SPLEN20249560 1783 889..1584 4226
    SPLEN20250170 1784 457..3012 4227
    SPLEN20250390 1785 1327..1788 4228
    SPLEN20252190 1786 1413..2609 4229
    SPLEN20261440 1787 511..894 4230
    SPLEN20264110 1788 1195..1662 4231
    SPLEN20267650 1789 39..1331 4232
    SPLEN20273950 1790 608..1222 4233
    SPLEN20279950 1791 1874..2518 4234
    SPLEN20280660 1792 1286..1612 4235
    SPLEN20283650 1793 13..621 4236
    SPLEN20284240 1794 282..1175 4237
    SPLEN20292950 1795 9..2456 4238
    SPLEN20293800 1796 73..858 4239
    SPLEN20303970 1797 778..1104 4240
    SPLEN20304950 1798 7..1011 4241
    SPLEN20305620 1799 1356..1853 4242
    SPLEN20329240 1800 5..361 4243
    STOMA20001830 1801 81..1574 4244
    STOMA20005390 1802 59..1567 4245
    STOMA20005670 1803 81..1478 4246
    STOMA20006400 1804 80..1687 4247
    STOMA20006780 1805 41..1975 4248
    STOMA20006860 1806 1272..1988 4249
    STOMA20008880 1807 112..1485 4250
    STOMA20010250 1808 66..419 4251
    STOMA20013890 1809 2151..2486 4252
    STOMA20026880 1810 548..874 4253
    STOMA20032890 1811 1710..2600 4254
    STOMA20034770 1812 81..1583 4255
    STOMA20036460 1813 311..772 4256
    STOMA20046680 1814 768..1154 4257
    STOMA20048520 1815 160..663 4258
    STOMA20048840 1816 936..1487 4259
    STOMA20051200 1817 140..619 4260
    STOMA20056640 1818 49..555 4261
    STOMA20056670 1819 81..1556 4262
    STOMA20057820 1820 60..1226 4263
    STOMA20062130 1821 35..427 4264
    STOMA20062290 1822 289..693 4265
    STOMA20063250 1823 109..438 4266
    STOMA20063980 1824 97..480 4267
    STOMA20064470 1825 78..1118 4268
    STOMA20067800 1826 35..397 4269
    STOMA20069040 1827 364..792 4270
    STOMA20072690 1828 351..701 4271
    STOMA20076800 1829 311..784 4272
    STOMA20077450 1830 780..2300 4273
    STOMA20080500 1831 59..1735 4274
    STOMA20083610 1832 80..1564 4275
    STOMA20086140 1833 201..746 4276
    STOMA20088380 1834 48..1535 4277
    STOMA20092530 1835 80..1501 4278
    STOMA20092560 1836 68..439 4279
    STOMA20092890 1837 105..1223 4280
    SYNOV20001520 1838 25..735 4281
    SYNOV20001730 1839 56..1480 4282
    SYNOV20002510 1840 79..1629 4283
    SYNOV20002790 1841 59..1480 4284
    SYNOV20002970 1842 56..1471 4285
    SYNOV20003970 1843 357..881 4286
    SYNOV20004260 1844 80..1489 4287
    SYNOV20007000 1845 55..1485 4288
    SYNOV20008240 1846 61..1494 4289
    SYNOV20009230 1847 40..1515 4290
    SYNOV20010880 1848 61..1479 4291
    SYNOV20011110 1849 56..1468 4292
    SYNOV20013000 1850 30..1433 4293
    SYNOV20013560 1851 79..1494 4294
    SYNOV20013900 1852 81..1499 4295
    SYNOV20017080 1853 466..1905 4296
    SYNOV30001840 1854 146..2443 4297
    TBAES20000590 1855 1697..>2237 4298
    TBAES20002550 1856 16..1896 4299
    TBAES20003150 1857 42..1064 4300
    TBAES20003770 1858 117..3437 4301
    TCOLN20001390 1859 237..1106 4302
    TESOP20000900 1860 110..448 4303
    TESOP20003120 1861 42..929 4304
    TESOP20004000 1862 295..1125 4305
    TESOP20005270 1863 568..921 4306
    TESOP20005690 1864 230..574 4307
    TESTI10000940 1865 127..1752 4308
    TESTI20001000 1866 129..944 4309
    TESTI20001170 1867 107..1291 4310
    TESTI20001720 1868 204..722 4311
    TESTI20002720 1869 92..>2187 4312
    TESTI20002780 1870 821..1471 4313
    TESTI20004890 1871 140..1231 4314
    TESTI20011200 1872 1615..1968 4315
    TESTI20017950 1873 62..2023 4316
    TESTI20018230 1874 506..1024 4317
    TESTI20023510 1875 100..1935 4318
    TESTI20029930 1876 597..1847 4319
    TESTI20030310 1877 1362..1757 4320
    TESTI20030890 1878 1736..2167 4321
    TESTI20031270 1879 820..1332 4322
    TESTI20031810 1880 235..1926 4323
    TESTI20035960 1881 80..1327 4324
    TESTI20036380 1882 125..2110 4325
    TESTI20037560 1883 16..1986 4326
    TESTI20038270 1884 42..347 4327
    TESTI20039400 1885 63..1430 4328
    TESTI20041690 1886 194..2320 4329
    TESTI20044230 1887 76..1308 4330
    TESTI20044310 1888 307..1899 4331
    TESTI20046750 1889 56..871 4332
    TESTI20057750 1890 154..495 4333
    TESTI20060400 1891 102..1754 4334
    TESTI20061110 1892 102..1574 4335
    TESTI20063830 1893 186..1793 4336
    TESTI20066670 1894 345..1823 4337
    TESTI20066770 1895 867..1937 4338
    TESTI20067200 1896 25..1149 4339
    TESTI20076850 1897 864..1307 4340
    TESTI20082330 1898 12..2249 4341
    TESTI20083200 1899 80..967 4342
    TESTI20083940 1900 60..1973 4343
    TESTI20086210 1901 65..1465 4344
    TESTI20087620 1902 116..2191 4345
    TESTI20088220 1903 318..2435 4346
    TESTI20094020 1904 341..1885 4347
    TESTI20094120 1905 402..1184 4348
    TESTI20094230 1906 1397..2158 4349
    TESTI20094470 1907 428..1540 4350
    TESTI20098350 1908 137..1849 4351
    TESTI20098530 1909 220..564 4352
    TESTI20102800 1910 278..640 4353
    TESTI20105720 1911 1542..1901 4354
    TESTI20108720 1912 101..1123 4355
    TESTI20110280 1913 212..1396 4356
    TESTI20112940 1914 579..899 4357
    TESTI20114070 1915 1575..1937 4358
    TESTI20116650 1916 43..387 4359
    TESTI20116830 1917 825..1208 4360
    TESTI20121550 1918 191..1900 4361
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  • Namely, primers used to synthesize polynucleotides can be designed based on the nucleotide sequences of polynucleotides of the present invention shown in SEQ ID NOs in the above Table 1. When one intends to synthesize full-length cDNAs, an oligo dT primer can be used as the 3′-end primer. The length of the primers is usually 15-100 bp, and favorably between 15-35 bp. In case of LA PCR, which is described below, the primer length of 25-35 bp may provide a good result.
  • A method to design a primer that enables a specific amplification based on the aimed nucleotide sequence is known to those skilled in the art (Current Protocols in Molecular Biology, Ausubel et al. edit, (1987) John Wiley & Sons, Section 6.1-6.4). In designing a primer based on the 5′-end sequence, the primer is designed so as that, in principle, the amplification products will include the translation start site. Accordingly, for example, when the 5′-end primer is designed based on the nucleotide sequence of 5′ untranslated region (5′UTR), any part of the 5′-end, which ensures the specificity to the cDNA of interest, can be selected as the primer.
  • When synthesizing a full-length cDNA, the target nucleotide sequence to be amplified can extend to several thousand bp in some cDNA. However, it is possible to amplify such a long nucleotides by using such as LA PCR (Long and Accurate PCR). It is advantageous to use LA PCR when synthesizing long DNA. In LA PCR, in which a special DNA polymerase having 3′->5′ exonuclease activity is used, misincorporated nucleotides can be removed. Accordingly, accurate synthesis of the complementary strand can be achieved even with a long nucleotide sequence. By using LA PCR, it is reported that amplification of a nucleotide with 20 kb longer can be achieved under desirable conditions (Takeshi Hayashi (1996) Jikken-Igaku Bessatsu, “Advanced Technologies in PCR” Youdo-sha).
  • A template DNA for synthesizing the full-length cDNA of the present invention can be obtained by using cDNA libraries that are prepared by various methods. The full-length cDNA clones of the present invention are clones with high probability of completeness in length, which were obtained by the method comprising the steps of [1] preparing libraries containing cDNAs with the very high fullness ratio by oligo-capping, and [2] assembling the 5′-end sequences and selecting one with the highest probability of completeness in length in the cluster formed (there are many clones longer in the 5′-end direction).
  • However, the uses of primers designed based on the full-length nucleotide sequences provided by the present invention enable easily obtaining full-length cDNAs without such a special technique.
  • The problem with the cDNA libraries prepared by the known methods or commercially available is that mRNA contained in the libraries has very low fullness ratio. Thus, it is difficult to screen full-length cDNA clone directly from the library using ordinary cloning methods. The present invention has revealed a nucleotide sequence of novel full-length cDNA. If a full-length nucleotide sequence is provided, it is possible to synthesize a target full-length cDNA by using enzymatic reactions such as PCR. In particular, a full-length-enriched cDNA library, synthesized by methods such as oligo-capping, is desirable to synthesize a full-length cDNA with more reliability.
  • The 5′-end sequence of the full-length cDNA clones of the invention can be used to isolate the regulatory element of transcription including the promoter on the genome. A rough draft of the human genome (analysis of human genomic sequence with lower accuracy), which covers 90% of the genome, has been reported (Nature, Vol. 409, 814-823, 2001), and by the year 2003, analysis of the entire human genomic sequence is going to be finished. However, it is hard to analyze with software the transcription start sites on the human genome, in which long introns exist. By contrast, it is easy to specify the transcription start site on the genomic sequence using the nucleotide sequence which includes the 5′-end of the full-length cDNA clone of the present invention, and thus it is easy to obtain the genomic region involved in transcription regulation, which includes the promoter that is contained in the upstream of the transcription start site.
  • The polypeptide encoded by the full-length cDNA of the invention can be prepared as a recombinant polypeptide or as a natural polypeptide. For example, the recombinant polypeptide can be prepared by inserting the polynucleotide encoding the polypeptide of the invention into a vector, introducing the vector into an appropriate host cell and purifying the polypeptide expressed within the transformed host cell, as described below. In contrast, the natural polypeptide can be prepared, for example, by utilizing an affinity column to which an antibody against the polypeptide of the invention (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 16.1-16.19) is attached. The antibody used for affinity purification may be either a polyclonal antibody, or a monoclonal antibody. Alternatively, in vitro translation (See, for example, “On the fidelity of mRNA translation in the nuclease-treated rabbit reticulocyte lysate system.” Dasso M. C., and Jackson R. J. (1989) Nucleic Acids Res. 17: 3129-3144) may be used for preparing the polypeptide of the invention.
  • Polypeptides functionally equivalent to the polypeptides of the present invention can be prepared based on the activities, which were clarified in the above-mentioned manner, of the polypeptides of the present invention. Using the biological activity possessed by the polypeptide of the invention as an index, it is possible to verify whether or not a particular polypeptide is functionally equivalent to the polypeptide of the invention by examining whether or not the polypeptide has said activity.
  • Polypeptides functionally equivalent to the polypeptides of the present invention can be prepared by those skilled in the art, for example, by using a method for introducing mutations into an amino acid sequence of a polypeptide (for example, site-directed mutagenesis (Current Protocols in Molecular Biology, edit, Ausubel et al., (1987) John Wiley & Sons, Section 8.1-8.5) Besides, such polypeptides can be generated by spontaneous mutations. The present invention also includes a polypeptide comprising the amino acid sequence shown in Table 1 in which one or more amino acids are substituted, deleted, inserted, and/or added, as long as the polypeptides have the equivalent functions to those of the polypeptides identified in the present Examples described later.
  • There are no limitations on the number and sites of amino acid mutations, as long as the polypeptides maintain the functions thereof. The number of mutations typically corresponds to 30% or less, or 20% or less, or 10% or less, preferably 5% or less, or 3% or less of the total amino acids, more preferably 2% or less or 1% or less of the total amino acids. Alternatively, herein, substitution of one or more amino acids includes substitution of several amino acids. As used herein, the term “several amino acids” means, for example, 5 amino acids, preferably 4 or 3 amino acids, more preferably 2 amino acids, and further preferably 1 amino acid.
  • From the viewpoint of maintaining the polypeptide function, it is preferable that a substituted amino acid has a similar property to that of the original amino acid. For example, Ala, Val, Leu, Ile, Pro, Met, Phe and Trp are assumed to have similar properties to one another because they are all classified into a group of non-polar amino acids. Similarly, substitution can be performed among non-charged amino acid such as Gly, Ser, Thr, Cys, Tyr, Asn, and Gln, acidic amino acids such as Asp and Glu, and basic amino acids such as Lys, Arg, and His.
  • In addition, polypeptides functionally equivalent to the polypeptides of the present invention can be isolated by using techniques of hybridization or gene amplification known to those skilled in the art. Specifically, using the hybridization technique (Current Protocols in Molecular Biology, edit, Ausubel et al., (1987) John Wiley & Sons, Section 6.3-6.4)), those skilled in the art can usually isolate a polynucleotide highly homologous to the polynucleotide encoding the polypeptide identified in the present Example based on the identified nucleotide sequence (Table 1) or a portion thereof and obtain the functionally equivalent polypeptide from the isolated polynucleotide. The present invention include polypeptides encoded by the polynucleotides hybridizing with the polynucleotides encoding the polypeptides identified in the present Example, as long as the polypeptides are functionally equivalent to the polypeptides identified in the present Example. Organisms from which the functionally equivalent polypeptides are isolated are illustrated by vertebrates such as human, mouse, rat, rabbit, pig and bovine, but are not limited to these animals.
  • Washing conditions of hybridization for the isolation of polynucleotides encoding the functionally equivalent polypeptides are usually “1×SSC, 0.1% SDS, 37° C.”; more stringent conditions are “0.5×SSC, 0.1% SDS, 42° C.”; and still more stringent conditions are “0.1×SSC, 0.1% SDS, 65° C.”. Alternatively, the following conditions can be given as hybridization conditions of the present invention. Namely, conditions in which the hybridization is done at “6×SSC, 40% Formamide, 25° C.”, and the washing at “1×SSC, 55° C.” can be given. More preferable conditions are those in which the hybridization is done at “6×SSC, 40% Formamide, 37° C.”, and the washing at “0.2×SSC, 55° C.”. Even more preferable are those in which the hybridization is done at “6×SSC, 50% Formamide, 37° C.”, and the washing at “0.1×SSC, 62° C.”. The more stringent the conditions of hybridization are, the more frequently the polynucleotides highly homologous to the probe sequence are isolated. Therefore, it is preferable to conduct hybridization under stringent conditions. Examples of stringent conditions in the present invention are, washing conditions of “0.5×SSC, 0.1% SDS, 42° C.”, or alternatively, hybridization conditions of “6×SSC, 40% Formamide, 37° C.”, and the washing at “0.2×SSC, 55° C.”.
  • One skilled in the art can suitably select various conditions, such as dilution ratios of SSC, formamide concentrations, and temperatures to accomplish a similar stringency.
  • However, the above-mentioned combinations of SSC, SDS and temperature conditions are indicated just as examples. Those skilled in the art can select the hybridization conditions with similar stringency to those mentioned above by properly combining the above-mentioned or other factors (for example, probe concentration, probe length and duration of hybridization reaction) that determines the stringency of hybridization.
  • The amino acid sequences of polypeptides isolated by using the hybridization techniques usually have high identity to those of the polypeptides of the present invention, which are shown in Table 1. The present invention encompasses a polynucleotide comprising a nucleotide sequence that has a high identity to the nucleotide sequence of claim 1(a). Furthermore, the present invention encompasses a peptide, or polypeptide comprising an amino acid sequence that has a high identity to the amino acid sequence encoded by the polynucleotide of claim 1(b). The term “high identity” indicates sequence identity of at least 40% or more; preferably 60% or more; and more preferably 70% or more. Alternatively, more preferable is identity of 90% or more, or 93% or more, or 95% or more, furthermore, 97% or more, or 99% or more. The identity can be determined by using the BLAST search algorithm.
  • As used herein, “percent identity” of amino acid sequences or nucleic acids is determined using the algorithm BLAST of Karlin and Altschul (Proc. Natl. Acad. Sci. USA 90:5873-5877, 1993). Such an algorithm is incorporated into the BLASTN and BLASTX programs of Altschul et al. (J. Mol. Biol.215:403-410, 1990). BLAST nucleotide searches are performed with the BLASTN program, for example, score=100, wordlength=12. BLAST protein searches are performed with the BLASTX program, for example, score=50, wordlength=3. When utilizing BLAST and Gapped BLAST programs, the default parameters of the respective programs are used. See http://www.ncbi.nlm.nih.gov.
  • With the gene amplification technique (PCR) (Current Protocols in Molecular Biology, edit, Ausubel et al., (1987) John Wiley & Sons, Section 6.1-6.4)) using primers designed based on the nucleotide sequence (Table 1) or a portion thereof identified in the present Example, it is possible to isolate a polynucleotide fragment highly homologous to the polynucleotide sequence or a portion thereof and to obtain functionally equivalent polypeptide to a particular polypeptide identified in the present Example based on the isolated polynucleotide fragment.
  • The present invention also provides a polynucleotide containing at least 15 nucleotides complementary to a polynucleotide comprising a nucleotide sequence of SEQ ID NOs shown in Table 1 or the complementary strand thereof. Herein, the term “complementary strand” is defined as one strand of a double strand DNA composed of A:T and G:C base pair to the other strand. Also, “complementary” is defined as not only those completely matching within a continuous region of at least 15 nucleotides, but also having a identity of at least 70%, favorably 80% or higher, more favorably 90% or higher, and most favorably 95% or higher within that region. The identity may be determined using the algorithm described herein.
  • Such a polynucleotide includes probes and primers used for the detection and amplification of a polynucleotide encoding the inventive polypeptide. When used as a primer, the polynucleotide usually comprises 15 to 100 bp, and preferably of 15 to 35 bp. When used as a probe, the polynucleotide comprises the whole or a part of the sequence of a polynucleotide of the invention, and comprises at least 15 bp. When used as primers, such polynucleotides are complementary at the 3′-end, and restriction enzyme recognition sequences or tags can be added to the 5′-end.
  • Furthermore, polynucleotides of the present invention include an antisense polynucleotide for suppressing the expression of a polypeptide of the invention, which comprises an amino acid sequence of SEQ ID NOs shown in Table 1. To exert an antisense effect, an antisense polynucleotide has at least 15 bp or more, for example 50 bp or more, preferably 100 bp or more, and more preferably 500 bp or more, and usually has 3000 bp or less, and preferably 2000 bp or less. Antisense polynucleotides can be used in the gene therapy of diseases caused by abnormalities of the polypeptides of the invention (abnormal function or abnormal expression). An antisense polynucleotide can be prepared, for example, by the phosphorothioate method (“Physicochemical properties of phosphorothioate oligodeoxynucleotides.” Stein (1988) Nucleic Acids Res. 16: 3209-3221) based on the sequence information of polynucleotide encoding a polypeptide of the invention (for example, the nucleotide sequences of SEQ ID NO: 1 to 2443).
  • The polynucleotides or antisense polynucleotides of the present invention can be used in, for example, gene therapy. As target diseases, for example, cancers or various inflammatory diseases may be preferable. These molecules can be used for gene therapy, for example, by administrating them to patients by the in vivo or ex vivo method using virus vectors such as retrovirus vectors, adenovirus vectors, and adeno-related virus vectors, or non-virus vectors such as liposomes.
  • The present invention also includes a partial peptide of the polypeptides of the invention. The partial peptide comprises a polypeptide generated as a result that a signal peptide has been removed from a secretory protein. If the polypeptide of the present invention has an activity as a receptor or a ligand, the partial peptide may function as a competitive inhibitor of the polypeptide and may bind to the receptor (or ligand). In addition, the present invention includes an antigen peptide for raising antibodies. For the peptides to be specific for the polypeptide of the invention, the peptides comprise at least 7 amino acids, preferably 8 amino acids or more, more preferably 9 amino acids or more, and even more preferably 10 amino acids or more. The peptide can be used for preparing antibodies against the polypeptide of the invention, or competitive inhibitors of them, and also screening for a receptor that binds to the polypeptide of the invention. The partial peptides of the invention can be produced, for example, by genetic engineering methods, known methods for synthesizing peptides, or digesting the polypeptide of the invention with an appropriate peptidase.
  • The present invention also relates to a vector into which a polynucleotide of the invention is inserted. The vector of the invention is not limited as long as it contains the inserted polynucleotide stably. For example, if E. coli is used as a host, vectors such as pBluescript vector (Stratagene) are preferable as a cloning vector. To produce the polypeptide of the invention, expression vectors are especially useful. Any expression vector can be used as long as it is capable of expressing the polypeptide in vitro, in E. coli, in cultured cells, or in vivo. For example, PBEST vector (Promega) is preferable for in vitro expression, pET vector (Invitrogen) for E. coli, pME18S-FL3 vector (GenBank Accession No. AB009864) for cultured cells, and pME18S vector (Mol. Cell. Biol. (1988) 8: 466-472) for in vivo expression. To insert the polynucleotide of the invention, ligation utilizing restriction sites can be performed according to the standard method (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.4-11.11).
  • Recently, the technique of GATEWAY™ system (Invitrogen), which is an expression vector construction system for polypeptide expression, has been developed (Experimental Medicine, Vol. 18, No. 19 (December), p2716-2717, 2000). This system includes two types of site-specific recombinases (BP CLONASE™ and LR CLONASE™) derived from lambda phage and uses BP CLONASE™-specific recombination sites for an Entry Vector and LR CLONASE™-specific recombination sites for a Destination Vector, which may comprise a tag useful for polypeptide purification. With this system, an expression vector can be obtained by using homologous recombination.
  • First, a polynucleotide fragment of interest is inserted into the entry vector using the first recombination. Then, the secondary recombination is allowed to take place between the entry vector, where the polynucleotide fragment of interest has been inserted, and the destination vector. Thus, the expression vector can be prepared rapidly and highly efficiently. With the above-mentioned typical method using restriction enzyme and ligase reactions, the step of expression vector construction and expression of polypeptide of interest takes about 7 to 10 days. However, with the GATEWAY™ system, the polypeptide of interest can be expressed and prepared in only 3 to 4 days. Thus, the system ensures a high-throughput functional analysis for expressed polypeptides (http://biotech.nikkeibp.co.jp/netlink/lto/gateway/).
  • The present invention also relates to a transformant carrying the vector of the invention. Any cell can be used as a host into which the vector of the invention is inserted, and various kinds of host cells can be used depending on the purposes. For strong expression of the polypeptide in eukaryotic cells, COS cells or CHO cells can be used, for example.
  • Introduction of the vector into host cells can be performed, for example, by calcium phosphate precipitation method, electroporation method (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 9.1-9.9), lipofectamine method (GIBCO-BRL), or microinjection method, etc.
  • Further, a polynucleotide containing at least 15 nucleotides comprising a nucleotide sequence of any one of the polynucleotides comprising the nucleotide sequences of SEQ ID NOs shown in Table 1 or the complementary strand thereof can be used not only as a primer for synthesizing full-length cDNAs but also for testing and diagnosing the abnormalities of the polypeptide encoded by the full-length cDNA of the present invention. For example, by utilizing polymerase chain reaction (genomic DNA-PCR, or RT-PCR) using the polynucleotide of the invention as a primer, polynucleotide encoding the polypeptide of the invention can be amplified. It is also possible to obtain the regulatory region of expression in the 5′-upstream by using PCR or hybridization since the transcription start site within the genomic sequence can be easily specified based on the 5′-end sequence of the full-length cDNA. The obtained genomic region can be used for detection and/or diagnosis of the abnormality of the sequence by RFLP analysis, SSCP, or sequencing. Especially, in the case where expression of the mRNA of the present invention varies according to a specific disease, analysis of the amount of expression of the mRNA using the polynucleotide of the present invention as a probe or a primer enables detection and diagnosis of the disease.
  • The present invention also relates to antibodies that bind to the polypeptide of the invention. There are no limitations in the form of the antibodies of the invention. They include polyclonal antibodies, monoclonal antibodies, or their portions that can bind to an antigen. They also include antibodies of all classes. Furthermore, special antibodies such as humanized antibodies and chimeric antibodies are also included.
  • The polyclonal antibody of the invention can be obtained according to the standard method by synthesizing an oligopeptide corresponding to the amino acid sequence and immunizing rabbits with the peptide (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.12-11.13). The monoclonal antibody of the invention can be obtained according to the standard method by purifying the polypeptide expressed in E. coli, immunizing mice with the polypeptide, and producing a hybridoma cell by fusing the spleen cells and myeloma cells (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.4-11.11).
  • The antibody binding to the polypeptide of the present invention can be used for purification of the polypeptide of the invention, and also for detection and/or diagnosis of the abnormalities of the expression and structure of the polypeptide. Specifically, polypeptides can be extracted, for example, from tissues, blood, or cells, and the polypeptide of the invention is detected by Western blotting, immunoprecipitation, or ELISA, etc. for the above purpose.
  • Furthermore, the antibody binding to the polypeptide of the present invention can be utilized for treating the diseases that associates with the polypeptide of the invention. If the antibodies are used for treating patients, human antibodies, humanized antibodies, or chimeric antibodies are preferable in terms of their low antigenicity. The human antibodies can be prepared by immunizing a mouse whose immune system is replaced with that of human (e.g., see “Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice” Mendez, M. J. et al. (1997) Nat. Genet. 15: 146-156). The humanized antibodies can be prepared by recombination of the hypervariable region of a monoclonal antibody (Methods in Enzymology (1991) 203: 99-121).
  • A cDNA of the present invention encodes, for example, an amino acid sequence of a protein that is predicted to have the following function. The use of the amino acid sequences of the polypeptides encoded by the cDNAs of the present invention enables predicting that the polypeptides have the following functions. It can be predict, from the results of homology search of SwissProt, GenBank, UniGene, or nr, that these polypeptides have such functions. Specifically, for instance, as shown in Examples, searching for a known gene or polypeptide that is homologous to the partial sequence of the full-length cDNA of the invention (2443 clone) and referring the function of the gene and of the polypeptide encoded by the gene make it possible to predict the function of the polypeptide encoded by the cDNA of the invention. In this way, each of 1216 clones out of the 2443 full-length cDNA clones of the invention was predicted to encode a polypeptide that was classified into the following categories.
  • Secretory and/or membrane protein (632 clones)
  • Glycoprotein-related protein (128 clones)
  • Signal transduction-related protein (84 clones)
  • Transcription-related protein (144 clones)
  • Disease-related protein (387 clones)
  • Enzyme and/or metabolism-related protein (206 clones)
  • Cell division- and/or cell proliferation-related protein (33 clones)
  • Cytoskeleton-related protein (75 clones)
  • Nuclear protein and/or RNA synthesis-related protein (65 clones)
  • Protein synthesis- and/or transport-related protein (62 clones)
  • Cellular defense-related protein (15 clones)
  • Development and/or differentiation-related protein (13 clones)
  • DNA- and/or RNA-binding protein (174 clones)
  • ATP- and/or GTP-binding protein (68 clones)
  • The functions of the polypeptides encoded by the cDNAs of the present invention can be predicted by assessing the presence of signal sequence, transmembrane region, nuclear translocation signal, glycosylation signal, phosphorylation site, and zinc finger motif, SH3 domain, etc. in the amino acid sequences. The programs, PSORT (Nakai K., and Kanehisa M. (1992) Genomics 14: 897-911), SOSUI (Hirokawa T. et al. (1998) Bioinformatics 14: 378-379) (Mitsui Knowledge Industry), and MEMSAT (Jones D. T., Taylor W. R., and Thornton J. M. (1994) Biochemistry 33: 3038-3049) can be used to predict the existence of the signal sequence or transmembrane region. Alternatively, a partial amino acid sequence of the polypeptide is fused with another polypeptide such as GFP, the fusion polypeptide is transfected into cultured cells, and the localization is analyzed to predict the function of the original polypeptide.
  • Based on the determined nucleotide sequences of the full-length cDNAs obtained in the present invention, it is possible to predict more detailed functions of the polypeptides encoded by the cDNA clones, for example, by searching the databases such as GenBank, Swiss-Prot, UniGene, and nr for homologies of the cDNAs; or by searching the amino acid sequences deduced from the full-length cDNAs for signal sequences by using software programs such as PSORT, for transmembrane regions by using software programs such as SOSUI or for motifs by using software programs such as Pfam (http://www.sanger.ac.uk/Software/Pfam/index.shtml) and PROSITE (http://www.expasy.ch/prosite/). As a matter of course, the functions are often predictable by using partial sequence information (preferably 300 nucleotides or more) instead of the full-length nucleotide sequences. However, the result of the prediction by using partial nucleotide sequence does not always agree with the result obtained by using full-length nucleotide sequence, and thus, it is needless to say that the prediction of function is preferably performed based on the full-length nucleotide sequences.
  • GenBank, Swiss-Prot, UniGene and nr databases were searched for homologies of the full-length nucleotide sequences of the 2443 clones (see Example 6). The amino acid sequences deduced from the full-length nucleotide sequences were searched for functional domains by PSORT, SOSUI and Pfam. Prediction of functions of polypeptides encoded by the clones and the categorization thereof were performed based on these results obtained. The categorization was carried out by the following method.
  • [1] Firstly, the cDNA clones were classified into the above-mentioned 14 functional categories based on the results of annotation-based categorization (using the keywords in the case of Swiss-Prot hit data; using Definition or Reference information in the case of GenBank, UniGene, or nr hit data), and the signal sequence search of the deduced ORFs by PSORT and the transmembrane region search by SOSUI.
  • [2] Secondly, clones which had been unassignable to the categories by the method of [1] were searched for functional domains and/or motifs by Pfam. Based on the results, the clones were additionally classified into the above-mentioned 14 types of categories when they had a functional domain and/or motif assignable to any one of the categories.
  • The following 632 clones presumably belong to secretory and/or membrane proteins.
  • ADIPS10000640, ADRGL10001470, ADRGL20013520, ADRGL20018540, ADRGL20035850, ASTRO20001410, ASTRO20005330, ASTRO20033160, ASTRO20055750, ASTRO20058630, ASTRO20190390, BEAST20004540, BGGI110000240, BNGH420088500, BRACE20006400, BRACE20038000, BRACE20038470, BRACE20039040, BRACE20039540, BRACE20051380, BRACE20053630, BRACE20059370, BRACE20060550, BRACE20061050, BRACE20063630, BRACE20067430, BRACE20069090, BRACE20081720, BRACE20101700, BRACE20101710, BRACE20116110, BRACE20147800, BRACE20153680, BRACE20163350, BRACE20179340, BRACE20188470, BRACE20195100, BRACE20201570, BRACE20210140, BRACE20224480, BRACE20224500, BRACE20228480, BRACE20232840, BRACE20238000, BRACE20273890, BRACE20274080, BRALZ20013500, BRALZ20054710, BRALZ20064740, BRALZ20069760, BRALZ20073760, BRALZ20077930, BRAMY20000860, BRAMY20002770, BRAMY20025840, BRAMY20039260, BRAMY20060920, BRAMY20063970, BRAMY20111960, BRAMY20112800, BRAMY20124260, BRAMY20134140, BRAMY20135900, BRAMY20136210, BRAMY20144620, BRAMY20152110, BRAMY20174550, BRAMY20181220, BRAMY20195090, BRAMY20211390, BRAMY20211420, BRAMY20215230, BRAMY20218250, BRAMY20218670, BRAMY20229800, BRAMY20231720, BRAMY20247280, BRAMY20252180, BRAMY20273960, BRAMY20277170, BRAMY20284910, BRAMY20285160, BRAWH20015350, BRAWH20015890, BRAWH20016860, BRAWH20018730, BRAWH20030250, BRAWH20064050, BRAWH20110790, BRAWH20112940, BRAWH20117950, BRAWH20118230, BRAWH20121640, BRAWH20122580, BRAWH20132190, BRCAN20064010, BRCAN20071190, BRCAN20091560, BRCAN20103740, BRCAN20224720, BRCAN20273550, BRCAN20280360, BRCAN20285450, BRCOC10000870, BRCOC20004040, BRCOC20006370, BRCOC20041750, BRCOC20077690, BRCOC20078640, BRCOC20090520, BRCOC20101230, BRCOC20107300, BRCOC20114180, BRCOC20121720, BRCOC20134480, BRCOC20136750, BRHIP10001290, BRHIP20000870, BRHIP20003120, BRHIP20103090, BRHIP20111200, BRHIP20118380, BRHIP20118910, BRHIP20121410, BRHIP20135100, BRHIP20174040, BRHIP20179200, BRHIP20183690, BRHIP20191490, BRHIP20191770, BRHIP20198190, BRHIP20207430, BRHIP20208270, BRHIP20208590, BRHIP20217620, BRHIP20233090, BRHIP20234380, BRHIP20238880, BRHIP20283030, BRHIP30004570, BRSSN20003120, BRSSN20043040, BRSSN20066110, BRSSN20120810, BRSSN20137020, BRSSN20142940, BRSSN20146100, BRSSN20151990, BRSSN20169050, BRSTN20002200, BRTHA20004740, BRTHA20046290, BRTHA20046420, COLON10001350, COLON20093370, CTONG10000100, CTONG10000940, CTONG10001650, CTONG20004690, CTONG20009770, CTONG20092570, CTONG20092580, CTONG20095340, CTONG20099380, CTONG20103480, CTONG20105080, CTONG20114740, CTONG20119200, CTONG20120770, CTONG20124730, CTONG20131490, CTONG20132220, CTONG20133480, CTONG20139340, CTONG20149950, CTONG20155400, CTONG20158660, CTONG20159530, CTONG20161850, CTONG20267700, D3OST10001090, D3OST20036070, D3OST20038560, D3OST30002580, D6OST20005070, D9OST20002780, D9OST20015470, D9OST20023970, D9OST20026730, D9OST20035940, D9OST20040180, DFNES20025880, FCBBF10000240, FCBBF10000380, FCBBF10001150, FCBBF10001210, FCBBF10001550, FCBBF10002430, FCBBF10002700, FCBBF10003220, FCBBF10003760, FCBBF10005460, FCBBF10005740, FCBBF20032970, FCBBF20042560, FCBBF20049300, FCBBF20051220, FCBBF30008470, FCBBF30024750, FCBBF30078290, FCBBF30083620, FCBBF30086440, FCBBF30090690, FCBBF30095260, FCBBF30123470, FCBBF30172550, FCBBF30175310, FCBBF30190850, FCBBF30215060, FCBBF30238870, FCBBF30251420, FCBBF30279030, FEBRA20002100, FEBRA20004620, FEBRA20009090, FEBRA20029860, FEBRA20037260, FEBRA20080810, FEBRA20086620, FEBRA20092890, FEBRA20093520, FEBRA20095880, FEBRA20111460, FEBRA20125070, FEBRA20130190, FEBRA20140100, FEBRA20145780, FEBRA20211710, FEBRA20223220, FEBRA20229630, FEBRA20235500, HCHON20000380, HCHON20008180, HCHON20015980, HCHON20016040, HCHON20016650, HCHON20040020, HCHON20064590, HCHON20067700, HCHON20068710, HCHON20086720, HCHON20100740, HEART20003060, HEART20005410, HEART20034320, HEART20049410, HEART20049800, HEART20072310, HHDPC20001040, HHDPC20014320, HHDPC20034720, HHDPC20068620, HHDPC20084140, HHDPC20091780, HHDPC20092080, HLUNG10000550, KIDNE20003940, KIDNE20007770, KIDNE20011400, KIDNE20021910, KIDNE20022620, KIDNE20100070, KIDNE20101510, KIDNE20109730, KIDNE20121880, KIDNE20125630, KIDNE20126010, KIDNE20126130, KIDNE20127450, KIDNE20130450, KIDNE20131580, KIDNE20137340, KIDNE20181660, LIVER20035110, LIVER20045650, LIVER20055200, LIVER20062510, LIVER20064690, LIVER20075680, LIVER20087060, LIVER20091180, MESAN10001260, MESAN20014500, MESAN20027090, MESAN20038510, MESAN20089360, MESAN20103120, MESAN20115970, MESAN20125860, MESAN20139360, MESAN20152770, MESAN20153910, MESAN20174170, NOVAR20000380, NT2NE20010050, NT2NE20021620, NT2NE20068130, NT2NE20118960, NT2NE20124480, NT2NE20131890, NT2NE20132170, NT2NE20155110, NT2NE20156260, NT2NE20157470, NT2NE20159740, NT2NE20177520, NT2NE20183760, NT2RI20003480, NT2RI20023910, NT2RI20025400, NT2RI20028470, NT2RI20040930, NT2RI20054050, NT2RI20056700, NT2RI20076290, NT2RI20086220, NT2RI20091940, NT2RI20244600, NT2RP70072690, NT2RP70081610, NT2RP70122910, NT2RP70125160, NT2RP70133740, NT2RP70134990, NT2RP70137290, NT2RP70179710, NT2RP70188020, NT2RP70192730, NT2RP70198350, NTONG20028070, NTONG20029700, NTONG20048060, NTONG20049910, NTONG20051530, NTONG20061870, NTONG20063010, NTONG20067830, NTONG20076930, NTONG20092330, OCBBF10001750, OCBBF20013890, OCBBF20019830, OCBBF20023570, OCBBF20026630, OCBBF20046690, OCBBF20050770, OCBBF20059560, OCBBF20063320, OCBBF20071210, OCBBF20072320, OCBBF20080050, OCBBF20086400, OCBBF20086910, OCBBF20087010, OCBBF20088140, OCBBF20091150, OCBBF20107090, OCBBF20108630, OCBBF20116850, OCBBF20120390, OCBBF20122620, OCBBF20130910, OCBBF20132850, OCBBF20145760, OCBBF20155060, OCBBF20178880, OCBBF20180120, OCBBF20180840, OCBBF20188730, PANCR10000910, PEBLM10000710, PEBLM20024320, PEBLM20040150, PEBLM20074370, PEBLM20075980, PERIC20004220, PLACE60086400, PLACE60121080, PLACE60161600, PLACE60177140, PROST20005050, PROST20050670, PROST20107820, PROST20116600, PROST20120160, PROST20127800, PROST20146010, PROST20164440, PROST20169800, PROST20170980, PROST20175290, PUAEN20003740, PUAEN20030180, SALGL10001710, SKMUS20003610, SKMUS20007800, SKMUS20011640, SKMUS20020840, SKMUS20028210, SKMUS20028400, SKMUS20077400, SKNSH20028660, SKNSH20031740, SKNSH20051940, SKNSH20063040, SMINT20009840, SMINT20011990, SMINT20022020, SMINT20029760, SMINT20040860, SMINT20050750, SMINT20053870, SMINT20073650, SMINT20095050, SMINT20100680, SMINT20105330, SMINT20106720, SMINT20121950, SMINT20127930, SMINT20144430, SMINT20144890, SMINT20153260, SMINT20154540, SMINT20157450, SMINT20173240, SMINT20178550, SMINT20191420, SMINT20192000, SPLEN20003070, SPLEN20021660, SPLEN20029310, SPLEN20079510, SPLEN20095810, SPLEN20097330, SPLEN20118300, SPLEN20141360, SPLEN20141990, SPLEN20142100, SPLEN20144520, SPLEN20152760, SPLEN20157880, SPLEN20165310, SPLEN20167200, SPLEN20169220, SPLEN20169720, SPLEN20171890, SPLEN20172120, SPLEN20179810, SPLEN20186430, SPLEN20211570, SPLEN20211940, SPLEN20213830, SPLEN20273950, SPLEN20292950, SPLEN20293800, SPLEN20304950, SPLEN20329240, STOMA20005390, STOMA20005670, STOMA20006400, STOMA20006780, STOMA20008880, STOMA20051200, STOMA20056640, STOMA20056670, STOMA20062130, STOMA20077450, STOMA20080500, STOMA20088380, STOMA20092530, SYNOV20001520, SYNOV20001730, SYNOV20002510, SYNOV20002790, SYNOV20002970, SYNOV20004260, SYNOV20007000, SYNOV20008240, SYNOV20009230, SYNOV20010880, SYNOV20011110, SYNOV20013000, SYNOV20013560, SYNOV20013900, SYNOV30001840, TBAES20003150, TESOP20004000, TESOP20005690, TESTI20001720, TESTI20036380, TESTI20037560, TESTI20094120, TESTI20110280, TESTI20123080, TESTI20123560, TESTI20128350, TESTI20136100, TESTI20136710, TESTI20143390, TESTI20148000, TESTI20164100, TESTI20193360, TESTI20209810, TESTI20209990, TESTI20211220, TESTI20214250, TESTI20216370, TESTI20230250, TESTI20231940, TESTI20242990, TESTI20244190, TESTI20254220, TESTI20254860, TESTI20265970, TESTI20271850, TESTI20272960, TESTI20284880, TESTI20291310, TESTI20291960, TESTI20303220, TESTI20303360, TESTI20303420, TESTI20307700, TESTI20309170, TESTI20314180, TESTI20316870, TESTI20333000, TESTI20335200, TESTI20347180, TESTI20347300, TESTI20352620, TESTI20357960, TESTI20370810, TESTI20373820, TESTI20383880, TESTI20390260, TESTI20390410, TESTI20391770, TESTI20393530, TESTI20396130, TESTI20397760, TESTI20401020, TESTI20401280, TESTI20415170, TESTI20421490, TESTI20422640, TESTI20441940, TESTI20442760, TESTI20444130, TESTI20444180, TESTI20449200, TESTI20463520, TESTI20463580, TESTI20465350, THYMU10005360, THYMU10005540, THYMU20027560, THYMU20032870, THYMU20039810, THYMU20066100, THYMU20081490, THYMU20100410, THYMU20106710, THYMU20111830, THYMU20141670, THYMU20147770, THYMU20159430, THYMU20161640, THYMU20162190, THYMU20173980, THYMU20194420, THYMU20208300, THYMU20216840, THYMU20222890, THYMU20229220, THYMU20241850, THYMU20277390, TKIDN20005210, TRACH20002870, TRACH20003590, TRACH20016210, TRACH20019960, TRACH20029540, TRACH20033230, TRACH20034840, TRACH20042920, TRACH20050040, TRACH20067620, TRACH20068660, TRACH20069180, TRACH20076740, TRACH20085400, TRACH20085830, TRACH20109650, TRACH20111130, TRACH20121380, TRACH20128110, TRACH20128230, TRACH20134950, TRACH20136710, TRACH20139820, TRACH20140820, TRACH20145440, TRACH20168350, TRACH20180840, TRACH20190240, UMVEN20000690, UTERU20030570, UTERU20040610, UTERU20046980, UTERU20055480, UTERU20064860, UTERU20076390, UTERU20094350, UTERU20135860, UTERU20144640, UTERU20158300, UTERU20158800, UTERU20161570, UTERU20178100, UTERU20183640, UTERU20186740
  • The following 128 clones presumably belong to glycoprotein-related proteins. ADIPS10000640, BRACE20059370, BRACE20163350, BRAMY20277170, BRAMY20285160, BRAWH20064050, BRAWH20112940, BRAWH20117950, BRAWH20118230, BRCAN20103740, BRCOC20004040, BRCOC20006370, BRHIP10001290, BRHIP20103090, BRHIP20283030, BRHIP30004570, BRSSN20003120, BRSSN20146100, BRTHA20046290, COLON10001350, CTONG20159530, D9OST20023970, D9OST20040180, FCBBF10001150, FCBBF20049300, FCBBF30024750, FCBBF30083620, FCBBF30190850, FCBBF30238870, FEBRA20086620, FEBRA20092890, HCHON20015980, HCHON20016040, HCHON20064590, HCHON20086720, HCHON20100740, HEART20003060, HHDPC20014320, HHDPC20068620, HHDPC20092080, KIDNE20003940, KIDNE20007770, KIDNE20101510, LIVER20064690, MESAN20125860, NT2NE20118960, NT2NE20157470, NT2NE20177520, NT2RI20003480, NT2RI20056700, NT2RP70192730, NTONG20051530, NTONG20076930, OCBBF20107090, OCBBF20108630, OCBBF20120390, OCBBF20145760, OCBBF20155060, PLACE60177140, SMINT20050750, SMINT20073650, SMINT20105330, SMINT20106720, SMINT20112730, SMINT20127930, SMINT20153260, SMINT20179740, SMINT20190170, SPLEN20021660, SPLEN20142100, SPLEN20157880, SPLEN20165310, SPLEN20179810, SPLEN20186430, STOMA20001830, STOMA20005390, STOMA20005670, STOMA20006400, STOMA20008880, STOMA20034770, STOMA20056640, STOMA20056670, STOMA20083610, STOMA20088380, STOMA20092530, SYNOV20001520, SYNOV20001730, SYNOV20002510, SYNOV20002790, SYNOV20002970, SYNOV20004260, SYNOV20007000, SYNOV20008240, SYNOV20009230, SYNOV20010880, SYNOV20011110, SYNOV20013000, SYNOV20013560, SYNOV20013900, TESOP20004000, TESTI20136100, TESTI20216370, TESTI20244190, TESTI20254860, TESTI20303220, TESTI20335200, TESTI20352620, TESTI20358980, TESTI20442760, TESTI20449200, TESTI20455090, THYMU10005360, THYMU10005540, THYMU20147770, THYMU20159430, THYMU20241850, TRACH20016210, TRACH20050040, TRACH20067620, TRACH20069180, TRACH20076740, TRACH20128230, UTERU20046980, UTERU20064860, UTERU20144640, UTERU20158800, UTERU20161570, UTERU20183640
  • The following 84 clones presumably belong to signal transduction-related proteins.
  • ASTRO20108190, BRACE20115920, BRACE20154120, BRACE20177200, BRACE20237270, BRAMY20104640, BRAMY20242470, BRAMY20271400, BRAWH20016620, BRAWH20103290, BRAWH20149340, BRCOC20021550, BRCOC20091960, BRHIP20189980, BRHIP20218580, BRHIP20238600, BRSSN20038200, CD34C30004240, CTONG20118150, CTONG20127450, CTONG20200310, FCBBF30012350, FCBBF40001730, FEBRA10001880, FEBRA20004620, FEBRA20132740, FEBRA20144170, FEHRT20003250, HCHON20007510, HLUNG20033780, IMR3220002430, KIDNE20008010, KIDNE20102710, KIDNE20107620, NT2NE20080170, NT2NE20181650, NT2RP70027380, NT2RP70036880, NT2RP70063950, NT2RP70078420, NT2RP70159960, NTONG20046140, NTONG20056570, OCBBF20028050, OCBBF20053430, OCBBF20054760, OCBBF20124360, OCBBF20127140, OCBBF20149280, OCBBF20173980, PEBLM20013120, PEBLM20085760, PROST20161950, PUAEN20015260, PUAEN20015860, PUAEN20083140, SMINT20028820, SMINT20049090, SMINT20110660, SPLEN20011410, SPLEN20121750, SPLEN20170310, SPLEN20181810, SPLEN20222270, SPLEN20250170, SPLEN20283650, TESTI20035960, TESTI20288910, TESTI20305540, TESTI20326810, TESTI20369650, TESTI20392250, TESTI20416640, TESTI20432750, TESTI20467320, THYMU20169680, THYMU20172150, THYMU20201980, THYMU20202890, TKIDN20004640, TKIDN20047480, TRACH20057690, UMVEN10001860, UTERU20146310
  • The following 144 clones presumably belong to transcription-related proteins.
  • 3NB6920014590, ADIPS20004250, ASTRO20008010, ASTRO20168470, BLADE20003400, BLADE20003890, BRACE20060890, BRACE20068590, BRACE20257100, BRAMY20210400, BRAMY20260910, BRAMY20270730, BRAWH20028110, BRAWH20075700, BRAWH20096780, BRCAN20280210, BRCOC20144000, BRCOC20178270, BRHIP20005340, BRHIP20096170, BRHIP20119330, BRHIP20191860, BRHIP20195890, BRHIP20222280, BRSSN20039370, BRSSN20046790, BRSSN20176820, CTONG20050280, CTONG20075860, CTONG20085950, CTONG20091080, CTONG20092700, CTONG20121010, CTONG20124220, CTONG20133390, CTONG20133520, D9OST20033970, FCBBF10001710, FCBBF10004370, FCBBF20059090, FCBBF20068820, FCBBF30007680, FCBBF30010810, FCBBF30018550, FCBBF30025560, FCBBF30057290, FCBBF30083820, FCBBF30129630, FCBBF30240960, FCBBF30246230, FEBRA20018690, FEBRA20026110, FEBRA20034680, FEBRA20040530, FEBRA20082010, FEBRA20171380, FEBRA20195820, FEBRA20233770, HCHON20008320, HCHON20009560, HCHON20035130, HHDPC10000830, HHDPC20030490, HHDPC20031130, KIDNE20027250, KIDNE20027950, KIDNE20182690, LIVER20055440, NT2NE20010490, NT2NE20089970, NT2NE20142210, NT2NE20184900, NT2RP60000770, NT2RP70043480, NT2RP70063950, NT2RP70102350, NT2RP70157890, NTONG20070200, OCBBF10001850, OCBBF20020830, OCBBF20037440, OCBBF20046120, OCBBF20049300, OCBBF20054200, OCBBF20066390, OCBBF20071840, OCBBF20080410, OCBBF20108190, OCBBF20125530, OCBBF20148280, PEBLM20060360, PEBLM20078320, PERIC20003870, PROST10003220, PROST20047390, PROST20066880, PROST20185830, PROST20189770, PROST20191640, SKNSH20008190, SMINT20001760, SMINT20028820, SMINT20130320, SMINT20144800, SPLEN20026950, SPLEN20054290, SPLEN20079260, SPLEN20095410, SPLEN20117660, SPLEN20140800, SPLEN20147390, SPLEN20160450, SPLEN20162680, SPLEN20243830, SPLEN20250170, SPLEN20252190, SPLEN20267650, STOMA20032890, STOMA20063250, TESTI20039400, TESTI20041690, TESTI20067200, TESTI20088220, TESTI20130010, TESTI20156100, TESTI20230850, TESTI20318090, TESTI20320670, TESTI20378190, TESTI20385960, TESTI20409890, TESTI20420620, TESTI20432820, TESTI20456110, THYMU20247480, TRACH20079690, TRACH20154860, TRACH20163170, TRACH20164980, TRACH20184490, UTERU20099720, UTERU20116570, UTERU20145480, UTERU20176130
  • The following 387 clones presumably belong to disease-related proteins.
  • ADIPS20004250, ADRGL10001470, ADRGL20011190, ADRGL20018300, ADRGL20035850, ADRGL20078100, ASTRO10001650, ASTRO20008010, ASTRO20027430, ASTRO20106150, ASTRO20108190, ASTRO20168470, BLADE20003400, BLADE20003890, BRACE20038480, BRACE20039540, BRACE20059370, BRACE20108130, BRACE20108880, BRACE20115920, BRACE20116460, BRACE20232840, BRACE20248260, BRACE20253330, BRACE20284100, BRALZ20013500, BRALZ20017430, BRALZ20018340, BRAMY20000520, BRAMY20025840, BRAMY20120910, BRAMY20134140, BRAMY20135900, BRAMY20162510, BRAMY20174550, BRAMY20210400, BRAMY20211390, BRAMY20242470, BRAMY20245300, BRAMY20266850, BRAMY20285160, BRAWH20016620, BRAWH20028110, BRAWH20064050, BRAWH20096780, BRAWH20110960, BRAWH20113430, BRAWH20114000, BRAWH20118230, BRAWH20121640, BRAWH20128270, BRAWH20137480, BRCAN20103740, BRCAN20224720, BRCAN20279700, BRCAN20280210, BRCAN20283190, BRCOC20001860, BRCOC20006370, BRCOC20027510, BRCOC20055420, BRCOC20099370, BRCOC20178270, BRCOC20178560, BRHIP20003120, BRHIP20005340, BRHIP20174040, BRHIP20176420, BRHIP20191490, BRHIP20191860, BRHIP20194940, BRHIP20195890, BRHIP20222280, BRHIP20249110, BRHIP20285930, BRHIP30004880, BRSSN20013420, BRSSN20038200, BRSSN20039370, BRSSN20046790, BRSSN20066110, BRSSN20101100, BRSSN20120810, BRSSN20187310, BRTHA20046290, CD34C30004240, COLON10001350, CTONG20004690, CTONG20052650, CTONG20099550, CTONG20124220, CTONG20125640, CTONG20128430, CTONG20131560, CTONG20133390, CTONG20153300, CTONG20153580, CTONG20158040, CTONG20159530, D6OST20003580, D9OST20023970, DFNES20001530, DFNES20037420, FCBBF10001210, FCBBF10001710, FCBBF10003770, FCBBF20059090, FCBBF20064520, FCBBF20068820, FCBBF30010810, FCBBF30024750, FCBBF30025560, FCBBF30039020, FCBBF30049550, FCBBF30057290, FCBBF30083620, FCBBF30129630, FCBBF30190850, FCBBF30238870, FCBBF30240960, FCBBF30243640, FCBBF30279030, FCBBF30281880, FCBBF40001730, FEBRA10001880, FEBRA20004620, FEBRA20010120, FEBRA20018690, FEBRA20082010, FEBRA20097310, FEBRA20130190, FEBRA20132740, FEBRA20144170, FEBRA20195820, FEBRA20223220, FEBRA20233770, FEBRA20235500, FEHRT20003250, HCHON10001760, HCHON20007380, HCHON20008320, HCHON20009560, HCHON20015230, HCHON20015980, HCHON20016040, HCHON20035130, HCHON20036420, HCHON20064590, HCHON20067700, HCHON20086720, HCHON20100740, HEART20003060, HEART20017730, HEART20025980, HEART20049410, HHDPC20014320, HHDPC20030490, HHDPC20084140, HHDPC20091140, HHDPC20091780, HHDPC20092080, HLUNG20033780, IMR3220002430, KIDNE20007770, KIDNE20020150, KIDNE20021680, KIDNE20022620, KIDNE20024830, KIDNE20027950, KIDNE20101370, KIDNE20101510, KIDNE20182690, LIVER20002160, LIVER20055200, LIVER20055440, LIVER20059810, LIVER20064690, MESAN20101140, MESAN20125860, MESAN20130220, MESAN20154010, MESAN20174170, NOVAR10000910, NT2NE20010490, NT2NE20118960, NT2NE20157470, NT2RI20040990, NT2RI20041880, NT2RI20048840, NT2RI20050960, NT2RI20240080, NT2RP60000770, NT2RP70027380, NT2RP70032610, NT2RP70037240, NT2RP70192730, NT2RP70198350, NTONG20013620, NTONG20015870, NTONG20028070, NTONG20067830, NTONG20070200, NTONG20090600, NTONG20092330, OCBBF20006770, OCBBF2003744.0, OCBBF20046120, OCBBF20049300, OCBBF20053490, OCBBF20053730, OCBBF20054760, OCBBF20071840, OCBBF20072240, OCBBF20078920, OCBBF20108430, OCBBF20108580, OCBBF20127140, OCBBF20129360, OCBBF20145760, OCBBF20153350, OCBBF20173980, OCBBF20178880, PEBLM10000710, PEBLM20013120, PERIC10000250, PLACE60060420, PLACE60177140, PROST20100460, PROST20159240, PROST20169800, PROST20176170, PUAEN20018820, PUAEN20030180, PUAEN20055020, PUAEN20083140, SKMUS20018230, SKMUS20018500, SKMUS20021530, SKMUS20024750, SKMUS20029200, SKMUS20048970, SKMUS20049030, SKNSH20008190, SKNSH20089400, SMINT20001760, SMINT20026890, SMINT20028820, SMINT20050750, SMINT20073650, SMINT20105330, SMINT20112730, SMINT20121220, SMINT20127350, SMINT20127930, SMINT20136130, SMINT20138900, SMINT20153260, SMINT20155180, SMINT20179740, SMINT20190170, SMINT20191420, SPLEN20006070, SPLEN20011410, SPLEN20026950, SPLEN20027440, SPLEN20039240, SPLEN20079260, SPLEN20095410, SPLEN20146450, SPLEN20147390, SPLEN20151210, SPLEN20160450, SPLEN20170310, SPLEN20179180, SPLEN20186430, SPLEN20212730, SPLEN20243830, SPLEN20245300, SPLEN20250390, SPLEN20252190, SPLEN20267650, SPLEN20305620, STOMA20001830, STOMA20005390, STOMA20008880, STOMA20010250, STOMA20034770, STOMA20046680, STOMA20056670, STOMA20064470, STOMA20077450, STOMA20080500, STOMA20083610, STOMA20088380, SYNOV20001520, SYNOV20001730, SYNOV20002790, SYNOV20002970, SYNOV20007000, SYNOV20008240, SYNOV20009230, SYNOV20010880, SYNOV20011110, TBAES20003770, TESOP20004000, TESOP20005270, TESTI20031270, TESTI20036380, TESTI20044310, TESTI20067200, TESTI20116830, TESTI20121550, TESTI20156100, TESTI20168480, TESTI20208400, TESTI20215990, TESTI20231940, TESTI20234360, TESTI20237520, TESTI20238610, TESTI20239510, TESTI20249990, TESTI20266740, TESTI20316870, TESTI20318090, TESTI20335050, TESTI20335200, TESTI20343570, TESTI20352620, TESTI20368330, TESTI20369650, TESTI20385960, TESTI20392250, TESTI20400940, TESTI20404240, TESTI20420620, TESTI20436560, TESTI20438570, TESTI20441940, TESTI20442760, TESTI20443090, TESTI20449200, TESTI20455090, TESTI20455620, TESTI20456110, TESTI20463580, TESTI20465350, TESTI20465690, TESTI20467210, THYMU20122730, THYMU20126900, THYMU20130890, THYMU20159430, THYMU20169680, THYMU20172150, THYMU20180280, THYMU20193640, THYMU20209590, THYMU20232090, THYMU20247480, TKIDN10000010, TKIDN20004640, TKIDN20047480, TRACH20016210, TRACH20019960, TRACH20050040, TRACH20057690, TRACH20067620, TRACH20077540, TRACH20079690, TRACH20096610, TRACH20105870, TRACH20121380, TRACH20154860, TRACH20162860, TRACH20163170, TRACH20164980, TRACH20190240, TSTOM20005690, TUTER20002830, UTERU20030570, UTERU20116570, UTERU20144640, UTERU20151980, UTERU20158800, UTERU20183640, UTERU20185230
  • The following 206 clones presumably belong to the category of enzymes and/or metabolism-related proteins.
  • 3NB6910001910, ADRGL10001470, ADRGL20035850, ADRGL20078100, ASTRO20105820, ASTRO20106150, ASTRO20130500, ASTRO20145760, BRACE20027620, BRACE20038000, BRACE20062640, BRACE20096200, BRACE20107530, BRACE20108130, BRACE20108880, BRACE20116460, BRACE20148240, BRACE20185680, BRACE20253160, BRALZ20017430, BRALZ20018340, BRAMY20104640, BRAMY20134140, BRAMY20153110, BRAMY20213100, BRAMY20252720, BRAWH20016620, BRAWH20105840, BRAWH20112940, BRAWH20114000, BRAWH20117950, BRAWH20125380, BRAWH20132190, BRAWH20171030, BRCAN20054490, BRCAN20224720, BRCAN20280360, BRCAN20283190, BRCAN20283380, BRCOC20001860, BRCOC20031250, BRCOC20055420, BRCOC20091960, BRCOC20144000, BRHIP10001290, BRHIP20005530, BRHIP20096850, BRHIP20103090, BRHIP20174040, BRHIP20249110, BRSSN20013420, BRSSN20015790, BRSSN20120810, BRSSN20146100, CTONG20095340, CTONG20106520, CTONG20118250, CTONG20127450, CTONG20140580, CTONG20153300, CTONG20158040, D3OST20006180, D6OST20003580, DFNES20031920, DFNES20071130, FCBBF10001820, FCBBF10003670, FCBBF30012350, FCBBF30012810, FCBBF30175310, FCBBF30243640, FEBRA10001880, FEBRA20007620, FEBRA20130190, FEBRA20144170, FEBRA20167390, FEBRA20196630, FEHRT20003250, HCHON10001760, HCHON20003220, HCHON20015350, HEART20034320, HEART20090000, HHDPC20014320; KIDNE20002520, KIDNE20008010, KIDNE20021680, KIDNE20022620, KIDNE20028390, KIDNE20028720, KIDNE20107620, LIVER20059810, MESAN20154010, NT2NE20118960, NT2NE20157470, NT2RI20005750, NT2RI20244600, NT2RI20273230, NT2RP70032610, NT2RP70045590, NT2RP70192730, NT2RP70195430, NTONG20009770, NTONG20013620, NTONG20046140, OCBBF20028650, OCBBF20030910, OCBBF20046690, OCBBF20050770, OCBBF20053430, OCBBF20053490, OCBBF20053730, OCBBF20054760, OCBBF20078920, OCBBF20124360, OCBBF20129360, OCBBF20178880, PEBLM20044520, PEBLM20052820, PEBLM20060490, PERIC10000250, PLACE50000660, PROST20083600, PROST20169800, PUAEN20015260, PUAEN20030180, SKMUS20018230, SMINT20028820, SMINT20049090, SMINT20102780, SMINT20105330, SMINT20106290, SMINT20110660, SMINT20152940, SMINT20191420, SMINT20191530, SPLEN20021660, SPLEN20026950, SPLEN20121750, SPLEN20145720, SPLEN20149240, SPLEN20150940, SPLEN20151210, SPLEN20173510, SPLEN20212730, SPLEN20250390, SPLEN20305620, STOMA20006860, STOMA20077450, TBAES20002550, TBAES20003150, TESOP20004000, TESOP20005270, TESTI20001000, TESTI20002720, TESTI20002780, TESTI20060400, TESTI20066670, TESTI20082330, TESTI20083200, TESTI20108720, TESTI20116830, TESTI20143390, TESTI20148000, TESTI20216370, TESTI20232140, TESTI20234360, TESTI20237520, TESTI20239510, TESTI20266740, TESTI20314180, TESTI20334410, TESTI20343570, TESTI20352620, TESTI20355020, TESTI20366910, TESTI20368330, TESTI20369650, TESTI20375340, TESTI20397760, TESTI20416640, TESTI20432750, TESTI20463580, TESTI20465350, TESTI20471410, TESTI20473830, THYMU20023380, THYMU20111830, THYMU20126900, THYMU20169680, THYMU20202890, TKIDN20004640, TKIDN20047480, TRACH20003590, TRACH20016210, TRACH20019960, TRACH20041830, TRACH20057690, TRACH20067620, TRACH20084720, TRACH20085830, TRACH20162860, UTERU20064860, UTERU20144640, UTERU20146310, UTERU20151980
  • The following 33 clones presumably belong to the category of cell division- and/or cell proliferation-related proteins.
  • BRALZ20077900, BRAMY20135900, BRAWH20002320, BRAWH20128270, BRCAN20071190, BRCAN20273640, BRHIP20096170, CTONG10000940, CTONG20124220, FCBBF30247930, FEBRA20113560, HCASM10000500, HCHON20097490, MESAN20025190, NT2RI20050960, OCBBF20039250, OCBBF20054760, OCBBF20072240, SMINT20051610, SPLEN20147110, SPLEN20284240, TESOP20005690, TESTI20234360, TESTI20305540, TESTI20332420, TESTI20335050, TESTI20368330, TESTI20392760, TESTI20400940, THYMU20161640, TKIDN20047480, UTERU20097760, UTERU20185230
  • The following 75 clones presumably belong to the category of cytoskeleton-related proteins.
  • ADRGL20011190, ADRGL20018300, ASTRO10001650, ASTRO20055750, BRACE20003070, BRACE20059370, BRACE20163350, BRAMY20121620, BRAMY20157820, BRAMY20242470, BRAWH20028110, BRAWH20137480, BRCAN20003460, BRCOC20008160, BRCOC20059510, BRHIP20115080, BRHIP20137230, BRHIP20167880, BRHIP20283030, BRHIP20285830, BRSSN20187310, CTONG10002770, CTONG20052900, CTONG20121580, FCBBF10001150, FCBBF30013770, FCBBF30015940, FCBBF30049550, FEBRA20024100, FEBRA20237640, HCHON20015980, HCHON20068410, HEART20017730, HEART20025980, HEART20061950, HEART20077670, HLUNG20016330, KIDNE20118580, MESAN20004570, NT2RI20040990, NT2RI20041880, NT2RP70037240, NT2RP70062230, NTONG20015870, NTONG20056570, NTONG20067830, NTONG20090600, OCBBF20107090, OCBBF20155060, PLACE60079250, PUAEN20040670, SKMUS20001980, SKMUS20016220, SKMUS20048970, SKMUS20049030, SMINT20024570, SMINT20026890, SMINT20121220, SMINT20138900, SPLEN20006070, SPLEN20027440, SPLEN20142100, TESTI20063830, TESTI20094230, TESTI20278400, TESTI20371030, TESTI20417300, TESTI20436560, TESTI20455090, THYMU20105190, THYMU20172150, THYMU20209590, TRACH20096610, UMVEN10001560, UTERU20116570
  • The following 65 clones presumably belong to the category of nuclear proteins and/or RNA synthesis-related proteins.
  • BRACE20057190, BRACE20064880, BRACE20248260, BRACE20253160, BRAMY20000520, BRAMY20120910, BRAWH20113430, BRAWH20171030, BRCAN10001490, BRCAN20283190, BRCOC20037320, BRCOC20178560, BRHIP20106100, BRHIP20176420, BRHIP20243470, BRSSN20101100, CTONG20114290, CTONG20125540, CTONG20131560, CTONG20140580, DFNES20001530, FCBBF20064520, FEBRA20007620, FEBRA20010120, FEBRA20097310, FEBRA20144170, FEBRA20174410, FEBRA20215500, IMR3220002430, MESAN20101140, NT2RI20273230, OCBBF20028650, OCBBF20030910, OCBBF20078920, PROST20104000, PUAEN20018820, SKMUS20007010, SMINT20127350, SMINT20177360, SMINT20191530, SPLEN20008740, SPLEN20146450, STOMA20046680, TESTI20082330, TESTI20094470, TESTI20121550, TESTI20208400, TESTI20234360, TESTI20237520, TESTI20249990, TESTI20334410, TESTI20355020, TESTI20368330, TESTI20392760, TESTI20408970, TESTI20436560, TESTI20438570, TESTI20443090, THYMU20193640, THYMU20202890, THYMU20241210, TRACH20096610, TUTER20002830, UTERU20151980, UTERU20176320
  • The following 62 clones presumably belong to the category of protein synthesis- and/or protein transport-related proteins.
  • 3NB6910001910, ASTRO20106150, ASTRO20130500, ASTRO20141350, BRACE20038480, BRACE20052160, BRACE20057620, BRACE20106840, BRACE20172980, BRACE20192440, BRAWH20110960, BRCOC20037320, BRHIP20005530, BRSSN20120810, BRSTN20005360, CTONG20009770, CTONG20114290, CTONG20125640, CTONG20153300, D6OST20003580, DFNES20037420, FCBBF30012810, FEBRA20080810, HCHON20064590, HHDPC20014320, HHDPC20084140, HLUNG20017120, LIVER20064690, NT2NE20132170, NT2NE20157470, NT2RP70133740, NTONG20009770, NTONG20075220, NTONG20076930, OCBBF20030910, OCBBF20035930, OCBBF20153340, PLACE60060420, SMINT20152940, SPLEN20008740, SPLEN20103950, SPLEN20118300, SPLEN20212730, SPLEN20250390, STOMA20077450, TBAES20002550, TESOP20004000, TESTI20239510, TESTI20278400, TESTI20314180, TESTI20463580, THYMU20111830, THYMU20122730, THYMU20130890, THYMU20232090, TKIDN10000010, TRACH20084720, TRACH20105870, TRACH20139820, TRACH20149970, UTERU20120310, UTERU20188110
  • The following 15 clones presumably belong to the category of cellular defense-related proteins.
  • BRCOC20144000, CTONG20092680, KIDNE20020150, LIVER20002160, NT2RI20050960, NT2RP70045590, OCBBF20128120, PLACE60003480, SKNSH20089400, SMINT20106290, SPLEN20039240, TESTI20001000, TESTI20455620, TRACH20028030, UTERU20176320
  • The following 13 clones presumably belong to the category of development and/or differentiation-related proteins.
  • 3NB6920014590, BRAMY20211390, CTONG20091080, CTONG20121010, FCBBF30024750, KIDNE20027250, NT2NE20142210, OCBBF20054200, PROST10003220, SKMUS20007010, SPLEN20179810, STOMA20063250, TESTI20291960
  • The following 174 clones presumably belong to the category of DNA- and/or RNA-binding proteins.
  • 3NB6920014590, ADIPS20004250, ASTRO20008010, ASTRO20168470, BLADE20003400, BLADE20003890, BRACE20057620, BRACE20060890, BRACE20064880, BRACE20068590, BRACE20248260, BRACE20253160, BRAMY20000520, BRAMY20213100, BRAMY20260910, BRAMY20270730, BRAWH20028110, BRAWH20075700, BRAWH20096780, BRAWH20113430, BRCAN10001490, BRCAN20280210, BRCAN20283190, BRCOC20144000, BRCOC20178270, BRCOC20178560, BRHIP20005340, BRHIP20106100, BRHIP20119330, BRHIP20153600, BRHIP20176420, BRHIP20191860, BRHIP20195890, BRHIP20222280, BRSSN20039370, BRSSN20046790, BRSSN20176820, CTONG20050280, CTONG20075860, CTONG20085950, CTONG20091080, CTONG20092700, CTONG20121010, CTONG20124220, CTONG20125540, CTONG20133390, CTONG20133520, CTONG20140580, CTONG20156780, D9OST20033970, FCBBF10001710, FCBBF10004370, FCBBF20059090, FCBBF20064520, FCBBF20068820, FCBBF30007680, FCBBF30010810, FCBBF30018550, FCBBF30025560, FCBBF30057290, FCBBF30083820, FCBBF30129630, FCBBF30240960, FCBBF30246230, FEBRA20010120, FEBRA20018690, FEBRA20026110, FEBRA20034680, FEBRA20040530, FEBRA20082010, FEBRA20097310, FEBRA20171380, FEBRA20195820, FEBRA20196630, FEBRA20233770, HCHON20008320, HCHON20009560, HCHON20035130, HHDPC10000830, HHDPC20031130, KIDNE20017130, KIDNE20027250, KIDNE20027950, KIDNE20107390, KIDNE20182690, LIVER20055440, MESAN20101140, NT2NE20010490, NT2NE20089970, NT2NE20142210, NT2NE20184900, NT2RP60000770, NT2RP70044280, NT2RP70102350, NT2RP70157890, NTONG20070200, OCBBF10001850, OCBBF20020830, OCBBF20037440, OCBBF20046120, OCBBF20049300, OCBBF20066390, OCBBF20071840, OCBBF20078920, OCBBF20080410, OCBBF20108190, OCBBF20125530, OCBBF20148280, PEBLM20060360, PEBLM20060490, PEBLM20078320, PERIC10000250, PROST10003220, PROST20047390, PROST20066880, PROST20185830, PROST20189770, PROST20191640, PUAEN20018820, SKNSH20008190, SKNSH20089400, SMINT20001760, SMINT20127350, SMINT20144800, SMINT20177360, SMINT20191530, SPLEN20054290, SPLEN20079260, SPLEN20095410, SPLEN20140800, SPLEN20147390, SPLEN20160450, SPLEN20252190, SPLEN20267650, STOMA20010250, STOMA20032890, STOMA20046680, STOMA20063250, TESTI20039400, TESTI20067200, TESTI20088220, TESTI20094470, TESTI20121550, TESTI20130010, TESTI20156100, TESTI20204450, TESTI20230850, TESTI20237520, TESTI20266740, TESTI20318090, TESTI20320670, TESTI20334410, TESTI20355020, TESTI20378190, TESTI20385960, TESTI20432820, TESTI20443090, TESTI20456110, THYMU20193640, THYMU20241210, THYMU20247480, TRACH20079690, TRACH20105870, TRACH20139820, TRACH20154860, TRACH20163170, TRACH20164980, TRACH20184490, TUTER20002830, UTERU20099720, UTERU20116570, UTERU20145480, UTERU20176130, UTERU20185230
  • The following 68 clones presumably belong to the category of ATP- and/or GTP-binding proteins.
  • 3NB6910001910, BRACE20108130, BRACE20148240, BRAMY20134140, BRAMY20157820, BRAMY20174550, BRAWH20164460, BRCAN20003460, BRCAN20054490, BRCAN20283190, BRCOC20059510, BRCOC20144000, BRHIP20103090, BRHIP20115080, BRHIP20167880, BRSTN20005360, CD34C30004240, CTONG20095340, CTONG20121580, CTONG20200310, DFNES20037420, FCBBF20067810, FCBBF30012350, FCBBF30015940, FEBRA20007620, FEBRA20024100, FEBRA20144170, KIDNE20020150, KIDNE20028720, LIVER20002160, LIVER20087060, NT2RI20005750, NT2RI20041880, NT2RI20048840, NT2RI20273230, OCBBF20028650, OCBBF20046690, OCBBF20054760, OCBBF20108430, OCBBF20108630, SMINT20121220, SMINT20183530, SMINT20191530, SPLEN20026950, SPLEN20039240, SPLEN20099700, SPLEN20145720, SPLEN20179180, STOMA20006860, TESTI20035960, TESTI20355020, TESTI20397760, TESTI20400940, TESTI20417300, TESTI20443090, TESTI20455620, THYMU20105190, THYMU20202890, THYMU20209590, TKIDN20004640, TKIDN20047480, TRACH20005400, TRACH20019960, TRACH20057690, TRACH20084720, UTERU20168220, UTERU20176320, UTERU20185230
  • Among the clones other than the ones shown above, BRAMY20248490, FCBBF10002800, NTONG20092290, OCBBF20127040, SMINT20163960, THYMU20279750, TRACH20167220, are clones which were predicted to highly possibly belong to the category of secretory protein and/or membrane protein based on the result of domain search by Pfam.
  • FCBBF10002800, NTONG20092290, OCBBF20127040, SMINT20163960, TESTI20478850, THYMU20279750
  • The 6 clones shown above are clones which were predicted to highly possibly belong to the category of glycoprotein-related protein based on the result of domain search by Pfam. BRACE20060720, BRACE20223330, BRALZ20058880, BRAMY20148130, BRAWH20101360, BRCAN20124080, BRHIP20253660, CTONG10000620, CTONG20014280, CTONG20124010, KIDNE20109890, MESAN20171520, OCBBF20109310, OCBBF20140640, PROST20079500, PUAEN20078980, SPLEN20077500, SPLEN20143180, TESTI20017950, TESTI20184620, TESTI20208710, TESTI20211160, TESTI20226230, TESTI20234140, TESTI20258460, TESTI20275030
  • The 26 clones shown above are clones which were predicted to highly possibly belong to the category of signal transduction-related protein based on the result of domain search by Pfam.
  • ADRGL20048330, ASTRO20064750, ASTRO20084250, BRACE20151320, BRALZ20058880, BRHIP20207990, CTONG20093950, FCBBF30195640, FEBRA10001900, FEBRA20090290, FEBRA20214970, FEBRA20222040, KIDNE20109890, LIVER20087510, MESAN20029400, MESAN20031900, MESAN20035290, MESAN20136110, NT2NE20130190, PEBLM20060310, PERIC20004780, PROST20171280, PUAEN20078980, SMINT20115880, SPLEN20095550, TESTI20023510, TESTI20083940, TESTI20152460, TESTI20185650, TESTI20189410, TESTI20200710, TESTI20308600, TESTI20343070, TESTI20369690, TESTI20381040, UTERU20050690
  • The 36 clones shown above are clones which were predicted to highly possibly belong to the category of transcription-related protein based on the result of domain search by Pfam. BGGI120006160, BRACE20053480, BRACE20190040, BRACE20223330, BRAWH20101360, BRAWH20185060, BRCOC20023230, BRHIP20252450, BRSSN20105870, BRSSN20117990, BRTHA20000570, CTONG20098440, CTONG20129960, CTONG20146300, CTONG20155180, FEBRA20025270, HEART20083640, KIDNE20009470, LIVER20035680, MESAN20029400, MESAN20031900, MESAN20186700, NOVAR10000150, NTONG20029480, OCBBF20079310, OCBBF20082830, PEBLM20042900, PLACE60136500, PLACE60136720, PROST20114390, SKNSH20020540, SMINT20013480, SMINT20174360, SPLEN20077500, SPLEN20119810, SPLEN20126190, SPLEN20174260, SPLEN20211220, TESTI20046750, TESTI20057750, TESTI20061110, TESTI20197940, TESTI20211160, TESTI20226230, TESTI20255820, TESTI20317600, TESTI20377230, THYMU20111180, THYMU20115850, THYMU20143270, THYMU20240710, UTERU20055330, UTERU20055930, UTERU20064000, UTERU20119060
  • The 55 clones shown above are clones which were predicted to highly possibly belong to the category of enzyme and/or metabolism-related protein based on the result of domain search by Pfam.
  • TESTI20127760, TESTI20392270
  • The 2 clone shown above is a clone which was predicted to highly possibly belong to the category of cell division and/or cell proliferation-related protein based on the result of domain search by Pfam.
  • FCBBF30262510, MESAN20031900, NT2NE20125050, SMINT20068010, SPLEN20163560, STOMA20092890, TESTI20382750
  • The 7 clones shown above are clones which were predicted to highly possibly belong to the category of cytoskeleton-related protein based on the result of domain search by Pfam.
  • THYMU20118520
  • The clone shown above is clone which was predicted to highly possibly belong to the category of Nuclear protein and/or RNA synthesis-related protein based on the result of domain search by Pfam.
  • BRACE20053480, BRACE20240740, KIDNE20009470, OCBBF20140890, SMINT20035690, UTERU20064000
  • The 6 clones shown above are clones which were predicted to highly possibly belong to the category of Protein synthesis-and/or transport-related protein based on the result of domain search by Pfam.
  • ADRGL20048330, ASTRO20064750, ASTRO20084250, BRACE20151320, BRACE20190040, BRACE20223330, BRALZ20058880, BRAMY20103570, BRCOC20023230, BRHIP20207990, BRTHA20000570, CTONG20093950, CTONG20129960, CTONG20146300, CTONG20155180, CTONG20160560, FCBBF10004120, FCBBF30195640, FEBRA10001900, FEBRA20090290, FEBRA20214970, FEBRA20222040, HCHON20008150, HEART20083640, KIDNE20109890, LIVER20035680, LIVER20087510, MESAN20029400, MESAN20031900, MESAN20035290, MESAN20136110, MESAN20186700, NT2NE20130190, NT2RI20025640, NTONG20029480, PEBLM20060310, PERIC20004780, PROST20114390, PROST20171280, PUAEN20078980, SMINT20115880, SPLEN20095550, SPLEN20119810, TESTI20023510, TESTI20057750, TESTI20083940, TESTI20152460, TESTI20185650, TESTI20189410, TESTI20200710, TESTI20308600, TESTI20343070, TESTI20369690, TESTI20381040, THYMU20115850, UTERU20050690, UTERU20055330
  • The 57 clones shown above are clones which were predicted to highly possibly belong to the category of DNA- and/or RNA-binding protein based on the result of domain search by Pfam.
  • PLACE60136720
  • The clone shown above is a clone which was predicted to highly possibly belong to the category of ATP- and/or GTP-binding proteins based on the result of domain search by Pfam.
  • The 213 clones shown below are clones which were unassignable to any of the above-mentioned categories, but have been predicted to have some functions based on homology search using their full-length nucleotide sequences and motif search in their estimated ORFs. Clone Name, Definition in the result of homology search or Motif Name in the motif search, demarcated by a double slash mark (//), are shown below.
  • ADRGL20028570//Rattus norvegicus MG87 mRNA, complete cds.
  • ADRGL20061930//transposon-derived Buster1 transposase-like protein
  • ASTRO20012490//Eukaryotic initiation factor 1A
  • ASTRO20072210//PERIAXIN.
  • ASTRO20114370//Mus musculus SMAR1 mRNA, complete cds.
  • ASTRO20125520//dnaj protein [Schizosaccharomyces pombe]
  • ASTRO20143630//KH domain// Bacterial regulatory proteins, crp family
  • ASTRO20155290//TPR Domain// TPR Domain// TPR Domain
  • ASTRO20181690//oocyte-specific protein P100
  • BGGI110001930//UBX domain
  • BRACE20011070//Mus musculus F-box protein FBX15 mRNA, partial cds.
  • BRACE20039440//Drosophila melanogaster CHARYBDE (charybde) mRNA, complete cds.
  • BRACE20050900//TPR Domain// TPR Domain// TPR Domain// TPR Domain
  • BRACE20053280//Mus musculus Pdz-containing protein (Pdzx) mRNA, complete cds.
  • BRACE20057730//toxin sensitivity protein KTI12 homolog
  • BRACE20058580//Homo sapiens HCMOGT-1 mRNA for sperm antigen, complete cds.
  • BRACE20063780//NOL1/NOP2/sun family
  • BRACE20269200//Heat-labile enterotoxin alpha chain
  • BRACE20276430//Homo sapiens retinoblastoma-associated protein RAP140 mRNA, complete cds.
  • BRACE20286360//Alpha adaptin carboxyl-terminal domain
  • BRAMY10001300//Homo sapiens MAGE-E1b mRNA, complete cds.
  • BRAMY20045240//Flagellar L-ring protein
  • BRAMY20054880//Rattus norvegicus KPL2 (Kp12) mRNA, complete cds.
  • BRAMY20167060//Collagen triple helix repeat (20 copies)
  • BRAMY20184670//Homo sapiens mRNA for ALEX1, complete cds.
  • BRAMY20217460//Homo sapiens cardiac voltage gated potassium channel modulatory subunit mRNA, complete cds, alternatively spliced.
  • BRAMY20240040//Homo sapiens suppressor of white apricot homolog 2 (SWAP2) mRNA, complete cds.
  • BRAMY20247110//Mus musculus semaphorin cytoplasmic domain-associated protein 3A (Semcap3) mRNA, complete cds.
  • BRAWH20004600//Mus musculus mRNA for NAKAP95, complete cds.
  • BRAWH20011710//cytoplasmic linker 2
  • BRAWH20012390//Trichomonas vaginalis mRNA for centrin (ce1 gene).
  • BRAWH20017010//Homo sapiens testes development-related NYD-SP22 mRNA, complete cds.
  • BRAWH20029630//Homo sapiens bet3 (BET3) mRNA, complete cds.
  • BRAWH20138660//Homo sapiens stonin 2 mRNA, complete cds.
  • BRCOC20008500//Human ras inhibitor mRNA, 3′ end.
  • BRCOC20026640//Gag P30 core shell protein
  • BRCOC20035130//14-3-3 PROTEIN EPSILON (MITOCHONDRIAL IMPORT STIMULATION FACTOR L SUBUNIT) (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) (14-3-3E).
  • BRCOC20074760//CDC4-LIKE PROTEIN (FRAGMENT).
  • BRCOC20110100//Integrase core domain
  • BRCOC20176520//Rattus norvegicus mRNA for type II brain 4.1, complete cds.
  • BRHIP20001630//Protein of unknown function DUF16
  • BRHIP20132860//Homo sapiens rhophilin-like protein mRNA, complete cds.
  • BRHIP20143730//MYND finger
  • BRHIP20175420//Mus musculus partial mRNA for stretch responsive protein 278 (sr278 gene).
  • BRHIP20236950//Outer Capsid protein VP4 (Hemagglutinin)
  • BRSSN20014260//RIBONUCLEASE INHIBITOR.
  • BRSSN20018690//Homo sapiens NY-REN-25 antigen mRNA, partial cds.
  • BRSSN20021600//RING CANAL PROTEIN (KELCH PROTEIN).
  • BRSSN20177570//Phosducin
  • BRSTN10000830//Kelch motif// Kelch motif// Kelch motif// Kelch motif
  • CTONG10000220//Mus musculus cerebellar postnatal development protein-1 (Cpd1) mRNA, partial cds.
  • CTONG10000930//Armadillo/beta-catenin-like repeats
  • CTONG20027090//Glypican// Leucine Rich Repeat// Leucine Rich Repeat
  • CTONG20076130//ZINC FINGER PROTEIN 185 (LIM-DOMAIN PROTEIN ZNF185) (P1-A).
  • CTONG20096750//Disintegrin
  • CTONG20100240//Mus musculus radial spokehead-L protein (Rshl1) mRNA, complete cds.
  • CTONG20139860//Homo sapiens nasopharyngeal carcinoma susceptibility protein LZ16 mRNA, complete cds.
  • CTONG20143690//MYND finger
  • CTONG20149460//RING CANAL PROTEIN (KELCH PROTEIN).
  • CTONG20165050//Keratin, high sulfur B2 protein
  • CTONG20186320//RING CANAL PROTEIN (KELCH PROTEIN).
  • D3OST20013280//ARP2/3 COMPLEX 16 KDA SUBUNIT (P16-ARC).
  • D3OST20024360//Homo sapiens neuroendocrine differentiation factor mRNA, complete cds.
  • D9OST20031370//Homo sapiens mRNA for partial putative TCPTP-interacting protein (ptpip5 gene).
  • DFNES20014040//TRICHOHYALIN.
  • FCBBF10000630//Homo sapiens huntingtin interacting protein HYPB mRNA, partial cds.
  • FCBBF10000770//Homo sapiens REC8 mRNA, partial cds.
  • FCBBF10005060//CELLULAR RETINALDEHYDE-BINDING PROTEIN (CRALBP).
  • FCBBF10005500//Keratin, high sulfur B2 protein
  • FCBBF20014270//ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR) (DBI) (ENDOZEPINE) (EP).
  • FCBBF20042170//Homo sapiens NIBAN mRNA, complete cds.
  • FCBBF30016320//SecA protein, amino terminal region
  • FCBBF30033050//Sm protein
  • FCBBF30054440//PLAT/LH2 domain
  • FCBBF30225660//Ank repeat// Ank repeat// Ank repeat// K+ channel tetramerisation domain// BTB/POZ domain
  • FCBBF30233680//G10 protein
  • FCBBF30246630//H. sapiens mRNA for ZYG homologue.
  • FCBBF30250730//TRICHOHYALIN.
  • FCBBF30252520//Homo sapiens bicaudal-D (BICD) mRNA, alternatively spliced, partial cds.
  • FCBBF30252800//NDRG1 PROTEIN (DIFFERENTIATION-RELATED GENE 1 PROTEIN) (DRG1) (REDUCING AGENTS AND TUNICAMYCIN-RESPONSIVE PROTEIN) (RTP) (NICKEL-SPECIFIC INDUCTION PROTEIN CAP43).
  • FCBBF30252850//Mus musculus peripherial benzodiazepine receptor associated protein (Pap7) mRNA, complete cds.
  • FCBBF30285280//Keratin, high sulfur B2 protein// Bacterial regulatory proteins, gntR family
  • FEBRA20088360//ALPHA-ADAPTIN C (CLATHRIN ASSEMBLY PROTEIN COMPLEX 2 ALPHA-C LARGE CHAIN) (100 KDA COATED VESICLE PROTEIN C) (PLASMA MEMBRANE ADAPTOR HA2/AP2 ADAPTIN ALPHA C SUBUNIT).
  • FEBRA20184330//Rattus norvegicus glutamate receptor interacting protein 2 (GRIP2) mRNA, complete cds.
  • FEBRA20192420//Cyclin-dependent kinase inhibitor// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif FEBRA20196370//Cyclin-dependent kinase inhibitor// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif
  • FEBRA20225040//high-glucose-regulated protein 8
  • HCHON20001560//TRANSCRIPTION FACTOR-LIKE PROTEIN MORF4.
  • HCHON20003440//Homo sapiens cyclin-D binding Myb-like protein mRNA, complete cds.
  • HCHON20010990//TPR Domain
  • HCHON20059870//Hypothetical protein.
  • HHDPC20034390//Cereal trypsin/alpha-amylase inhibito
  • HHDPC20057420//Mus musculus proline-rich protein (Bprp) mRNA, complete cds.
  • HHDPC20064600//SUPPRESSOR PROTEIN SRP40.
  • HLUNG20023340//Mus musculus SLM-1 (Slm1) mRNA, complete cds.
  • KIDNE20007210//Xenopus laevis mRNA for RPA interacting protein alpha (ripalpha gene).
  • KIDNE20028830//K-box region
  • KIDNE20115080//Homo sapiens mRNA for hNBL4, complete cds.
  • KIDNE20124400//Homo sapiens mRNA for ALEX1, complete cds.
  • KIDNE20127100//Drosophila melanogaster Diablo (dbo) mRNA, complete cds.
  • KIDNE20127750//Homo sapiens partial mRNA for transport-secretion protein 2.1 (TTS-2.1 gene).
  • KIDNE20190740//Rattus norvegicus SNIP-b mRNA, complete cds.
  • LIVER10004790//EF hand
  • LIVER20011130//Homo sapiens F-box protein FBL9 mRNA, partial cds.
  • LIVER20064100//Ciona intestinalis mRNA for myoplasmin-C1, complete cds.
  • LIVER20080530//Drosophila melanogaster forked mRNA for large Forked protein, complete cds.
  • MAMGL10000830//Drosophila melanogaster L82B (L82) mRNA, complete cds.
  • MESAN20036460//Corticotropin-releasing factor family
  • MESAN20127350//myelin expression factor-3
  • MESAN20141920//Human ovarian cancer downregulated myosin heavy chain homolog (Doc1) mRNA, complete cds.
  • NT2NE20010400//Homo sapiens GL013 mRNA, complete cds.
  • NT2NE20122430//GLYOXYLATE-INDUCED PROTEIN.
  • NT2NE20158600//erythroid ankyrin-Synechocystis sp. (strain PCC 6803).
  • NT2RI20001330//Homo sapiens KE03 protein mRNA, partial cds.
  • NT2RI20009870//lunatic fringe precursor [Mus musculus]
  • NT2RI20046080//recA bacterial DNA recombination proteins
  • NT2RI20091730//Molluscan rhodopsin C-terminal tail
  • NT2RP60000850//Bos taurus RPGR-interacting protein-1 (RPGRIP1) mRNA, complete cds.
  • NT2RP70080850//SPRY domain// Adenovirus EB1 55K protein/large t-an
  • NT2RP70105210//Myc amino-terminal region
  • NT2RP70188710//Yeast PIR proteins
  • NT2RP70194450//Bacterial regulatory proteins, crp family NTONG20052650//Gallus gallus Xin mRNA, complete cds.
  • NTONG20064400//REPETIN.
  • NTONG20064840//Mus musculus slp1 mRNA for synaptotagmin-like protein 1, complete cds.
  • NTONG20066460//Mus musculus Gd mRNA for gasdermin, complete cds.
  • NTONG20067090//Mus musculus mRNA for Sh3yl1, complete cds.
  • NTONG20070340//collagen alpha 1 (IX) chain
  • NTONG20083650//TPR Domain// TPR Domain// TPR Domain// PPR repeat// TPR Domain// PPR repeat// TPR Domain
  • NTONG20088620//Homo sapiens genethonin 3 mRNA, partial cds.
  • OCBBF10000540//Mus musculus rjs (rjs) mRNA, complete cds.
  • OCBBF20019380//seizure related gene 6
  • OCBBF20022900//Homo sapiens SCHIP-1 mRNA, complete cds.
  • OCBBF20030280//Rattus norvegicus hfb2 mRNA, complete cds.
  • OCBBF20046470//ARFAPTIN 1.
  • OCBBF20049840//Homo sapiens mRNA for neurabin II protein.
  • OCBBF20068490//Mus musculus RW1 protein mRNA, complete cds.
  • OCBBF20071960//Coturnix coturnix japonica qMEF2D gene.
  • OCBBF20073540//Homo sapiens p30 DBC mRNA, complete cds.
  • OCBBF20121390//RING CANAL PROTEIN (KELCH PROTEIN).
  • OCBBF20127550//Outer Capsid protein VP4 (Hemagglutinin)
  • OCBBF20148730//RING CANAL PROTEIN (KELCH PROTEIN).
  • OCBBF20178150//Plasmodium falciparum ADA2-like protein gene, partial cds.
  • PEBLM10000240//Domain found in Dishevelled, Eg1-10, and Ple
  • PROST20047270//CRAL/TRI0 domain.
  • PROST20112970//Sterile alpha motif (SAM)/Pointed domain// SAM domain (Sterile alpha motif)
  • PUAEN10000850//Uncharacterized protein family UPF0025// Sec1 family
  • PUAEN20011880//Mus musculus mRNA for MIWI (piwi), complete cds.
  • PUAEN20051100//Mus musculus otogelin mRNA, complete cds.
  • PUAEN20108240//Drosophila melanogaster ankyrin 2 (Ank2) mRNA, complete cds.
  • SKMUS20084740//Syndecan domain
  • SMINT20053300//Homo sapiens hepatocellular carcinoma-associated antigen 59 mRNA, complete cds.
  • SMINT20071400//NOL1/NOP2/sun family
  • SMINT20101440//Human cisplatin resistance associated alpha protein (hCRA alpha) mRNA, complete cds.
  • SMINT20110330//pKID domain
  • SMINT20122910//Mus musculus StAR-related protein 1-4E mRNA, partial cds.
  • SMINT20131810//ENV polyprotein (coat polyprotein)
  • SMINT20168570//Homo sapiens mRNA for stabilin-1 (stab1 gene).
  • SPLEN20008390//Human placenta (Diff48) mRNA, complete cds.
  • SPLEN20084600//RING CANAL PROTEIN (KELCH PROTEIN).
  • SPLEN20128000//Xenopus laevis XMAB21 (Xmab-21) mRNA, complete cds.
  • SPLEN20149110//Dishevelled specific domain
  • SPLEN20171470//Keratin, high sulfur B2 protein
  • SPLEN20194050//Homo sapiens HOTTL protein mRNA, complete cds.
  • SPLEN20214580//Mus musculus mdg1-1 mRNA, complete cds.
  • STOMA20057820//Uncharacterized protein family UPF0024
  • STOMA20063980//Collagen triple helix repeat (20 copies)
  • STOMA20069040//Keratin, high sulfur B2 protein
  • SYNOV20017080//UBX domain
  • TBAES20000590//Cytochrome P450// Cytochrome P450
  • TESTI20001170//HORMA domain
  • TESTI20031810//Bacterial luciferase// Domain of unknown function DUF28
  • TESTI20044230//Mus musculus testis-specific Y-encoded-like protein (Tspy11) mRNA, complete cds.
  • TESTI20098350//VAT-Nn domain
  • TESTI20157520//K+ channel tetramerisation domain// K+ channel tetramerisation domain
  • TESTI20170350//Cystine-knot domain
  • TESTI20192800//Homo sapiens nasopharyngeal carcinoma susceptibility protein LZ16 mRNA, complete cds.
  • TESTI20199750//TRICHOHYALIN.
  • TESTI20202650//Repeat in HS1/Cortactin
  • TESTI20229600//Drosophila melanogaster SP2353 mRNA, complete cds.
  • TESTI20231920//Gag P30 core shell protein
  • TESTI20242830//E2 (early) protein, C terminal// Syndecan domain
  • TESTI20254540//Homo sapiens hepatocellular carcinoma-associated antigen 59 mRNA, complete cds.
  • TESTI20320440//THIOREDOXIN.
  • TESTI20327680//EF hand// EF hand
  • TESTI20328280//KE2 family protein// Troponin
  • TESTI20351830//K-box region
  • TESTI20370020//Bleomycin resistance protein
  • TESTI20391210//IQ calmodulin-binding motif
  • TESTI20408150//Keratin, high sulfur B2 protein
  • TESTI20451990//SAP domain
  • TESTI20467970//Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain
  • THYMU20108310//Mouse NCBP-29 mRNA for PW29, complete cds.
  • THYMU20142040//WISKOTT-ALDRICH SYNDROME PROTEIN HOMOLOG (WASP).
  • THYMU20194360//Kelch motif
  • THYMU20239000//collagen alpha 1(XI) chain
  • TOVAR20004760//Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat
  • TRACH20005020//Ank repeat// MutT-like domain
  • TRACH20007020//TRICHOHYALIN.
  • TRACH20048450//PROTEIN K4 (PROTEIN K3).
  • TRACH20068700//Homo sapiens adaptor protein CIKS mRNA, complete cds.
  • TRACH20076760//Keratin, high sulfur B2 protein
  • TRACH20135520//TBC domain// Rhodanese-like domain
  • TRACH20141240//Mus musculus G21 protein mRNA, complete cds.
  • TRACH20183170//Rattus norvegicus Sprague-Dawley SM-20 mRNA, complete cds.
  • UTERU20000740//Human fusion protein mRNA, complete cds.
  • UTERU20004240//CGI-96 protein
  • UTERU20006960//endoplasmic reticulum resident protein 58
  • UTERU20022940//Human (p23) mRNA, complete cds.
  • UTERU20046640//Mus musculus ldlBp (LDLB) mRNA, complete cds.
  • UTERU20065930//GTP-RHO BINDING PROTEIN 1 (RHOPHILIN).
  • UTERU20115740//Human PMS2 related (hPMSR3) gene, complete cds.
  • UTERU20179880//TPR Domain// TPR Domain// TPR Domain// TPR Domain
  • Further, the reason is that a polypeptide does not always belong solely to a single category of the above-described functional categories, and therefore, a polypeptide may belong to any of the predicted functional categories. Besides, additional functions can be found for the clones classified into these functional categories by further analyses.
  • Since the polypeptide encoded by clones of the invention contains full-length amino acid sequence, it is possible to analyze its biological activity, and its effect on cellular conditions such as cell proliferation and differentiation by expressing the polypeptide as a recombinant polypeptide using an appropriate expression system, injecting the recombinant into the cell, or raising a specific antibody against the polypeptide.
  • The biological activities of respective polypeptides can be analyzed by the methods as shown below.
  • Secretory Protein, Transmembrane Protein:
    • “Ion Channels” (Ed., R. H. Ashley, 1995) of “The Practical Approach Series” (IRL PRESS),
    • “Growth Factors” (Eds., I. McKay, I. Leigh, 1993),
    • “Extracellular Matrix” (Eds., M. A. Haralson, J. R. Hassell, 1995);
      Glycoprotein-Related Protein:
    • “Glycobiology” (Eds., M. Fukuda, A. Kobata, 1993) of “The Practical Approach Series” (IRL PRESS),
    • “Glycoprotein Analysis in Biomedicine” (Ed., Elizabeth F. Hounsell, 1993) of “Method in Molecular Biology” (Humana Press) series;
      Signal Transduction-Related Protein:
    • “Signal Transduction” (Ed., G. Milligan, 1992) of “The Practical Approach Series” (IRL PRESS),
    • “Protein Phosphorylation” (Ed., D. G. Hardie, 1993), or
    • “Signal Transduction Protocols” (Eds., David A. Kendall, Stephen J. Hill, 1995) of “Method in Molecular Biology” (Humana Press) series;
      Transcription-Related Protein:
    • “Gene Transcription” (Eds., B. D. Hames, S. J. Higgins, 1993) of “The Practical Approach Series” (IRL PRESS),
    • “Transcription Factors” (Ed., D. S. Latchman, 1993); Enzyme and/or metabolism-related protein:
    • “Enzyme Assays” (Eds., ROBERT EISENTHAL and MICHAEL J. DANSON, 1992) of “The Practical Approach Series” (IRL PRESS);
      Cell Division and/or Cell Proliferation-Related Protein:
    • “Cell Growth, Differentiation and Senescence” (Ed., GEORGE STUDZINSKI, 2000) of “The Practical Approach Series” (IRL PRESS);
      Cytoskeleton-Related Protein:
    • “Cytoskeleton: Signalling and Cell Regulation” (Eds., KERMIT L. CARRAWAY and CAROLIE A. CAROTHERS CARRAWAY, 2000) of “The Practical Approach Series” (IRL PRESS),
    • “Cytoskeleton Methods and Protocols” (Ed., Gavin, Ray H., 2000) of “Method in Molecular Biology” (Humana Press) series;
      Nuclear Protein and/or RNA Synthesis-Related Protein:
    • “Nuclear Receptors” (Ed., DIDIER PICARD, 1999) of “The Practical Approach Series” (IRL PRESS),
    • “RNA Processing” (Eds., STEPHEN J. HIGGINS and B. DAVID HAMES, 1994);
      Protein Synthesis and/or Transport-Related Protein:
    • “Membrane Transport” (Ed., STEPHEN A. BALDWIN, 2000) of “The Practical Approach Series” (IRL PRESS),
    • “Protein Synthesis Methods and Protocols” (Eds., Martin, Robin, 1998) of “Method in Molecular Biology” (Humana Press) series;
      Cellular Defense-Related Protein:
    • “DNA Repair Protocols” (Henderson, Daryl S., 1999) of “Method in Molecular Biology” (Humana Press) series,
    • “Chaperonin Protocols” (Eds., Schneider, Christine, 2000); Development and/or differentiation-related protein:
    • “Developmental Biology Protocols” (Eds., ROBERT EISENTHAL and MICHAEL J. DANSON, 1992) of “Method in Molecular Biology” (Humana Press) series;
      DNA- and/or RNA-Binding Protein:
    • “DNA-Protein Interactions Principles and Protocols” (Eds., Kneale, G. Geoff, 1994) of “Method in Molecular Biology” (Humana Press) series,
    • “RNA-Protein Interaction Protocols” (Eds., Haynes, Susan R., 1999);
      ATP- and/or GTP-Binding Protein:
    • “Signal Transduction Protocols” (Eds., David A. Kendall, Stephen J. Hill, 1995) of “Method in Molecular Biology” (Humana Press) series.
  • In the categorization, the clone predicted to belong to the category of secretory and/or membrane protein means a clone having hit data with some annotation, such as growth factor, cytokine, hormone, signal, transmembrane, membrane, extracellular matrix, receptor, G-protein coupled receptor, ionic channel, voltage-gated channel, calcium channel, cell adhesion, collagen, connective tissue, etc., suggesting that it was a secretory or membrane protein, or a clone in which the presence of nucleotide sequence encoding a signal sequence or transmembrane region was suggested by the results of PSORT and SOSUI analyses for deduced ORF.
  • The clone predicted to belong to the category of glycoprotein-related protein means a clone having hit data with some annotation, such as glycoprotein, suggesting that the clone encodes a glycoprotein-related protein.
  • The clone predicted to belong to the category of signal transduction-related protein means a clone having hit data with some annotation, such as serine/threonine-protein kinase, tyrosine-protein kinase, SH3 domain, SH2 domain, etc., suggesting that the clone encodes a signal transduction-related protein.
  • The clone predicted to belong to the category of transcription-related protein means a clone having hit data with some annotation, such as transcription regulation, zinc finger, homeobox, etc., suggesting that the clone encodes a transcription-related protein.
  • The clone predicted to belong to the category of disease-related protein means a clone having hit data with some annotation, such as disease mutation, syndrome, etc., suggesting that the clone encodes a disease-related protein, or a clone whose full-length nucleotide sequence has hit data for Swiss-Prot, GenBank, UniGene, or nr, where the hit data corresponds to genes or polypeptides which have been deposited in the Online Mendelian Inheritance in Man (OMIM) (http://www.ncbi.nlm.nih.gov/Omim/), which is the human gene and disease database described later.
  • The clone predicted to belong to the category of enzyme and/or metabolism-related protein means a clone having hit data with some annotation, such as metabolism, oxidoreductase, E. C. No. (Enzyme commission number), etc., suggesting that the clone encodes an enzyme and/or metabolism-related protein.
  • The clone predicted to belong to the category of cell division and/or cell proliferation-related protein means a clone having hit data with some annotation, such as cell division, cell cycle, mitosis, chromosomal protein, cell growth, apoptosis, etc., suggesting that the clone encodes a cell division and/or cell proliferation-related protein.
  • The clone predicted to belong to the category of cytoskeleton-related protein means a clone having hit data with some annotation, such as structural protein, cytoskeleton, actin-binding, microtubles, etc., suggesting that the clone encodes a cytoskeleton-related protein.
  • The clone predicted to belong to the category of nuclear protein and/or RNA synthesis-related protein means a clone having hit data with some annotation, such as nuclear protein, RNA splicing, RNA processing, RNA helicase, polyadenylation, etc., suggesting that the clone encodes a nuclear protein and/or RNA synthesis-related protein.
  • The clone predicted to belong to the category of protein synthesis and/or transport-related protein means a clone having hit data with some annotation, such as translation regulation, protein biosynthesis, amino-acid biosynthesis, ribosomal protein, protein transport, signal recognition particle, etc., suggesting that the clone encodes a protein synthesis and/or transport-related protein.
  • The clone predicted to belong to the category of cellular defense-related protein means a clone having hit data with some annotation, such as heat shock, DNA repair, DNA damage, etc., suggesting that the clone encodes a cellular defense-related protein.
  • The clone predicted to belong to the category of development and/or differentiation-related proteins means a clone having hit data with some annotation, such as developmental protein, etc., suggesting that the clone encodes a development and/or differentiation-related protein.
  • The clone predicted to belong to the category of DNA-and/or RNA-binding protein means a clone having hit data with some annotation, such as DNA-binding, RNA-binding, etc.
  • The clone predicted to belong to the category of ATP-and/or GTP-binding protein means a clone having hit data with some annotation, such as ATP-binding, GTP-binding, etc.
  • As to a protein involved in a disease, it is possible to perform a functional analysis as described above, but also possible to analyze correlation between the expression or the activity of the protein and a certain disease by using a specific antibody that is obtained by using expressed protein. Alternatively, it is possible to utilize the database OMIM, which is a database of human genes and diseases, to analyze the protein. Further, new information is constantly being deposited in the OMIM database. Therefore, it is possible for one skilled in the art to find a new relationship between a particular disease and a gene of the present invention in the most up-to-date database. The proteins involved in diseases are useful for developing a diagnostic marker or medicines for regulation of their expression and activity, or as a target of gene therapy.
  • Also, as for a secretory protein, membrane protein, signal transduction-related protein, glycoprotein-related protein, or transcription-related protein, etc., search of the OMIM with the following keywords resulted in the finding that the proteins are involved in many diseases (the result of the OMIM search for secrete and membrane proteins is shown below). Also, association between proteins related to signal transduction or transcription and diseases is reported in “Transcription Factor Research-1999” (Fujii, Tamura, Morohashi, Kageyama, and Satake edit, (1999) Jikken-Igaku Zoukan, Vol. 17, No.3), and “Gene Medicine” (1999) Vol. 3, No.2). When cancer is used as an example, as described in “Biology of Cancer” (S. Matsubara, 1992) of Life Science series (Shokabo), many proteins are involved in cancers, which include enzyme and/or metabolism-related proteins, cytoskeleton-related proteins, cell division and/or cell proliferation-related proteins as well as secretory proteins, membrane proteins, signal transduction-related proteins, glycoprotein-related proteins, transcription-related proteins. As clearly seen by the above example, it is evident that not only disease-related proteins but also secretory proteins, membrane proteins, signal transduction-related proteins, glycoprotein-related proteins, transcription-related proteins, etc. are often involved in diseases, and thus they can be useful targets in the field of medical industry.
  • The result of the OMIM search for secretory and membrane proteins is shown below, in which the keywords,
  • (1) secretion protein,
  • (2) membrane protein,
  • (3) channel, and
  • (4) extracellular matrix were used.
  • Shown in the search result are only the accession numbers in the OMIM. Using the number, data showing the relationship between a disease and a gene or protein can be seen. The OMIM data has been renewed everyday.
  • 1) Secretion Protein
  • 354 entries found, searching for “secretion protein”
  • *604667, *104760, *176860, *151675, *139320, *107400, *604029, *118910, #200100, *176880, *603850, *147572, *604028, *179513, *125950, *139250, *246700, *600946, *600560, *602926, 185860, *605083, *603215, *602421, *157147, *179512, *600174, *109270, *604710, *138120, *179510, *600998, *179509, *170280, *179511, *600626, *603831, *601489, *154545, *179490,
  • *603826, *122559, *603216, *102720, *147290, *164160, *603062, *112262, *602672, *605435, *605322, *131230, *601652, *603166, *601746, *601591, *179508, #160900, *104311, *600759, *147545, *167805, #104300, *167770, #219700, *168470, *601684, *602049, *601146, *605227, *602434, *602534, *114840, *603489, *604323, *107470, *600753, *600768, *118825, *600564,
  • *604252, *173120, *134370, *192340, *308230, *600322, *605359, *600046, *300090, 106160, *600041, #262500, *605563, *150390, *158106, *182590, #103580, *104610, #173900, *134797, *143890, #145980, *306900, *308700, *176300, *227500, *137350, #154700, *138079, *600760, *107730, *142410, *147670, *124092, *590050, *152760, *600509, *605646, *201910, *227600,
  • *152790, *300200, *300300, 300800, *138160, *107741, *120150, *601199, *120180, *120160, *176730, *133170, *122560, *107300, *137241, *120140, *101000, *193400, *217000, *272800, *600937, #201710, *600377, #174800, *106100, #274600, *173350, #177170, *147620, *214500, *131244, *202110, *120120, *601007, *191160, *147470, *603372, *600733, *252800, *190160,
  • *138040, *158070, *162151, #125700, #130070, *113811, *603355, *171060, *136435, #184700, *603732, *190180, *164008, *186590, *120220, *604312, *152200, *138130, *605085, *605353, *600840, #166210, *188545, *207750, *173360, *601933, #194050, *153450, *138850, *253200, *307030, *157145, *600514, *600262, *264080, *147380, *600281, #204000, #227810, *232200,
  • *188826, *232800, *161561, #166200, *188400, *153620, *182099, *218040, #265800, *172400, #177200, *176805, #211600, #214700, #176410, *152780, *600633, *601771, *301500, *605402, *601922, *307800, *147892, *147720, *312060, #520000, *147660, *106150, *602358, *107270, *601769, *147440, *604558, *131530, *600270, *601610, *603692, *603401, *600423, *601604,
  • *603345, #125853, *602843, *142640, *603044, *605740, *134830, *602779, *130660, *139191, *137035, *600761, *601340, *600823, *107740, *130160, *600877, *605110, *600945, *130080, *600957, #130050, *605580, *118444, *601124, *124020, 122470, *120700, *603201, *137216, *601185, *138945, *218030, *600839, #240600, #262400, #162300, *162330, *188450, #265850,
  • *263200, *162641, *300159, *601038, #191390, *201810, *601398, *602384, *131240, *602423, *139392, *142703, *602663, *232700, *602682, #602722, *602730, *600734, *188540, *182452, *601538, *603061, *146880, *603140, *603160, *142704, #252650, *182280, *125255, *603252, #131750, *182139, *182100, #259420, #261100, *603493, *601745, *182098, *603795, *123812,
  • *600264, *147940, *180246, *180245, *118888, #604284, *168450, *118455, *604398, *604433, *601919, *118445, *600031, *604961, *605032, *605033, *171050, #171300, *131243, *109160, *605254, 274900, #171400, *600042, *151670, *184600, *605470, *605546, *176760, *602008, *102200, *605720, *600732, *605901
  • 2) Membrane Protein
  • 1489 entries found, searching for “membrane protein”
  • *130500, *605704, *305360, *153330, *173610, *109270, *170995, *170993, *104776, *602333, *309060, *605703, *120920, *605943, *602690, *159430, *600897, *133090, *601178, *602413, *602003, *604405, *605940, *603237, *109280, *600378, *602173, *107776, *602334, *602335, *125305, *601134, *309845, *605731, *154045, *603241, *603718, *600594, *603214, *185881,
  • *603657, *600182, *603177, *605331, *601476, *605456, *601114, *605190, *600723, *603904, *136950, *300222, *602879, *185880, *605348, *300096, *602257, *177070, *310200, *603062, *603344, *600039, *602977, *300100, *128240, *600959, *600322, *227400, *186945, *600946, *602534, *602048, *182900, *601097, *600267, *602625, *136430, *602421, *601047, *107450,
  • *143450, *603141, *184756, *164730, *159440, *154050, *600579, *312080, *604202, *603700, *600447, *256540, *604691, *158343, *600403, *602414, *137290, *176640, *176981, *600179, *600754, *604456, *604693, *605875, *604605, *188860, *300172, *602910, *604323, *219800, *601848, *60.3179, *600279, *602251, #222700, *603831, *605072, *605377, *601028, *604155,
  • *108733, *104225, *601896, *601510, *173335, *107770, *601767, *600046, *603850, *600040, *603784, *603234, 188560, *605863, *121015, *605862, *605861, *186946, *604252, *603215, *142461, *604597, *603143, *605264, *603735, *176860, *605536, *176801, *180721, *603355, *104760, *131560, *310300, *602631, *304700, #309400, *603142, *143890, *605431, *600753,
  • *115501, *176790, *600266, *601691, *168468, *601239, *602216, #104300, *605613, *601595, *605550, *125950, *605475, *602217, *602261, *603534, *602262, *604631, *190315, *601313, *604306, *104311, *604672, *605000, *602461, *605548, *602296, *604376, *121014, *121011, *600691, *604262, *139310, *304040, *605445, *179514, *179512, *151460, #160900, *120130,
  • *128239, *601158, *601403, *176943, *601014, 300800, *300294, *601757, *185470, *273800, *605034, *602887, #185000, *604871, *603593, *603583, *605454, *104775, *605872, *141180, *602713, *603531, *139150, *601531, *601832, *605452, *134651, *604156, *120620, *605883, *604142, *166945, *605324, *600816, *604699, *300112, *605182, *600164, *182180, *605071,
  • *300023, *605057, *308240, *300249, *176947, *176894, *605081, *605035, *602044, *182860, *107271, *305100, *153390, *113730, *602689, *180069, *603518, *300017, *191275, *177061, *601693, *601789, *604241, *600934, *138160, *604424, *603868, *600174, *600718, *600523, *604141, *601009, *605251, *600481, *600874, *155550, *605227, *601017, *162230, 601138,
  • *604157, *601212, *600763, *604110, *604158, *601107, *601326, 600621, *600587, 601137, *600917, *600855, *605058, *194355, *605194, *603291, *102720, *136425, *170715, *603216, *605547, *135630, *602926, *600168, *605002, *602474, *600157, *603025, *603893, *231200, *120090, *601966, *131230, *604722, *604721, *604515, *246700, *602101, *605628, *303630,
  • *605787, *602857, *602285, *605708, *602488, *605025, *603817, *300051, *603293, *176878, *603646, 605707, 185860, *112205, *300187, *602654, *120070, *603648, *604850, *602655, *602514, *300118, *182309, *179590, *602701, *600759, *204200, *604170, *175100, #103580, *147670, *306400, *143100, *182870, *257220, *180380, #116920, *301000, *193300, *157147,
  • *131550, *139200, *139130, *190195, *605406, *155760, *155960, *605734, *155970, *605385, *111700, *155975, *150370, 605709, *151430, *605438, *151510, *116952, *157655, *158105, *605777, *176877, *153619, *120131, *185430, *109190, *120190, *109170, *605093, *605250, *153432, *107777, *186590, *160993, *605699, *605698, *605813, *605697, *605616, *605300,
  • *162060, *605219, *163970, *135620, *165040, *605478, *604964, *103195, *604932, *604923, *605906, *605496, *605914, *166490, 138277, *604915, *114070, *605213, *605933, *180297, *101000, *191163, *191164, *605101, *603167, *600772, *603164, *600708, *604001, *191328, *313440, *602672, *604009, *604299, *192974, *604256, *603048, *600515, *604221, *602632,
  • *604196, *601179, 603290, *604661, *601023, *601110, *304800, *203200, *300212, *602933, *603352, *208900, *604418, *604838, *600551, #212140, *604837, *602049, *600552, *600553, *300213, *602574, *600583, *600932, *603452, *604775, *516020, *604617, *604464, *603498, *300145, *601523, *602694, *600632, *604762, *604492, *400015, *604504, *601717, *601728,
  • *300242, *602426, *604194, *603821, *604730, *600695, *603823, *603869, *300241, *600707, *603822, *602370, *602202, *604193, *601181, *604089, *602507, *604195, *602306, *300284, *601805, *601895, *601275, *604660, *600752, *603820, *604192, *602207, *308230, *600894, *312600, *603199, *604029, *602500, *102680, *235200, #256300, *601633, #219700, 262890,
  • *156225, *173470, *193400, *173910, *600354, *113705, *600065, *107741, *107400, *600024, *131195, *113811, #118220, *601638, *300011, *276903, *604144, *311770, *601758, #173900, *604592, *120120, *179605, *603130, *603372, *110750, *222900, *602509, *256100, *602469, *602281, *229300, *224100, *110900, *190180, *261600, *602997, *603616, *603189, 601791,
  • *601567, *312700, *171060, *308700, *604027, *162643, *516000, *176261, *604028, *314850, #145980, *601383, *600930, *305900, *601253, *136350, *605537, *138140, *604033, *605070, *139250, *300500, *603967, *300041, *603866, #130600, *120150, *601050, *604942, *605204, *605248, *272750, *600163, *604235, *600682, *107266, *306900, *191092, #262500, *600106,
  • *152790, *186720, *227650, *153700, *308380, *103390, *605646, *164920, *604478, #252650, *173850, *173350, *602505, *246530, *194380, *602575, *603030, #209920, *212138, #214100, *605767, *600582, *189980, #176200, *604653, *604678, *256550, *300037, *253700, #253300, #226700, *604766, #244400, *190000, *188040, *604824, *214500, #237500, *232300, *605014,
  • *604477, *190930, *605124, *604475, *604594, #227810, *306700, #301050, *600135, *600143, *605145, #269920, *300104, *277900, *300135, *300231, *192500, *182138, *191190, *176805, *600185, *186591, *604889, *603051, *165360, *147545, *601040, #156575, *107269, *603009, *602934, *123825, *601081, *602924, *163890, *600381, *602909, *150330, *109690, *123900,
  • *603434, *603491, *110700, *602581, *125647, #154700, *114760, *141900, *603690, *120220, *601199, #145500, *601309, *602382, *120325, *600877, *604205, *604090, *601497, *602377, *605464, *138720, *603728, *120950, *604026, *600580, *601610, *137167, *603960, *603931, *601880, *603126, *138190, *130130, *601997, *601975, *600395, *516040, *600418, *600650,
  • *605245, *605172, *600509, *164761, *310400, *600308, *605109, *600544, *600359, *600103, *605267, *312610, *176100, *308100, *158070, *605123, *173325, #312750, *600839, *158120, #604369, *604465, *173510, #161200, *151525, *605369, *604237, *516050, #600886, *604517, *165180, *605381, *605399, *307800, *604365, *155740, *147795, 601709, *604673, *147730,
  • *602122, *147557, *193245, *600978, *604990, *603261, *603274, *601007, *131100, *602941, *107941, *146710, *276901, *131244, *602872, *603411, *186357, *176290, *601066, *185050, *232200, *143030, *601843, #236700, *604122, *142800, *134638, *604985, *182380, *603930, *142410, *137060, *604586, *601193, *120650, *252500, *253800, *120930, *604858, *605874,
  • 601274, *602158, *605873, *193210, *203100, *601295, *604095, #201710, *126150, *108740, #205400, *601373, *300167, *109545, *602894, *603361, #300257, *266200, *603401, *131390, *180470, *605908, *604798, #221770, *223360, *180901, *605641, *605745, *604018, *300200, *604603, *230800, *602676, #604004, *605692, *602640, *601599, *134637, *245900, *118425,
  • 601614, *605725, *120110, *300189, *300035, *603102, *250800, *602282, *602458, *123610, *603754, *300278, *601463, *300224, *601581, *182160, *601653, *139191, *601733, *600748, *142460, *601194, *152390, *153620, *601615, *601814, *601617, *601613, *300191, #308300, *600798, 601858, *601872, *601597, #601588, *600821, *147840, *152427, *138850, *600823,
  • *601492, *300256, *600840, *300267, *601411, *139080, *139090, 600851, *300334, *179080, *602095, *601284, *601282, #177200, *601681, *601252, *176000, *602184, *602188, #266510, #154020, *186711, *257200, *601711, *600667, *602241, *186745, *255125, *300126, *600644, *123890, #255120, #175200, *600004, *302060, *123580, *186760, *122561, *602316, *600017,
  • *120940, 140300, *151690, *120700, *602354, *600019, *600857, *182175, *600536, *158380, *600516, *120290, *600493, *182310, #252010, *182530, *186830, *601839, *142790, *159465, *118990, *250790, *248600, #248250, *186845, *601153, *142600, *116930, *114860, *171834, #303600, *186880, *600444, *142871, *601852, *602602, *602607, *114207, *186910, #232220,
  • 600880, *134635, *112203, #112100, *111680, *231680, *311030, *111250, *111200, *134390, #226670, #145600, *226200, *602714, *171760, *133550, *602727, *161555, *602744, *602746, #131705, *602835, *600423, *176267, *602859, #600918, 277175, *602874, *601020, *109770, *600170, *217070, *173515, *602893, *147280, *154360, *171050, *108780, *176257, *600979,
  • *600377, *108360, *204500, *170260, *146880, *154582, *601011, *600997, *602992, *201475, *603005, *190198, *147360, #270400, *600238, #164970, *306250, #126600, *193065, #181350, *106180, *602136, *600937, *603086, *603087, *307030, *182099, *103320, *601683, #192430, *103180, *102681, *192321, *600244, *191740, *191315, *603152, *102642, *191305, #266140,
  • *100500, *600867, *604585, *604404, *604345, *603201, *605430, *603207, *603208, *605433, *604101, *603969, *605896, *604616, *605851, *605768, *604576, *605754, *605730, *605477, *603263, *605538, *603283, *604402, *605453, *605427, *603302, *605458, 603313, *604415, *603345, *605541, *603353, *605295, *603879, *605268, *605266, *605246, *603377, *603380,
  • *605181, *604203, *603425, *603867, *605106, *605017, *603842, *604936, *603510, *604857, *605932, *605816, *603765, *603551, *605357, *605237, *604204, *603594, *605110, *604190, *603861, *604962, *603639, *603644, *605007, *605349, *604943, *604918, *604907, *603667, *603681, *605396, *605561, *603712, *603713, *605688, *605942, *604878, *604843, *604659,
  • *604671, *603798, *604682, *604056, *604705, *603749, 602586, *603647, *602515, #602475, *603717, *602359, *602372, *602380, *602518, *603652, *602573, *603626, 602587, *603598, *602871, *603613, *603750, *603875, *602608, *602666, *602345, *602935, *603564, *603548, *603927, 601876, *602343, *603943, *603787, *601730, *601611, *602679, *603788, *602243,
  • 603790, *601535, *603796, *601488, *601485, *602314, *601478, *604047, *604048, *602297, *604057, *602715, *602192, *601459, *601416, *603833, *602190, *604102, *602106, *604111, *602724, *603499, *602736, *601123, *601002, *600923, *601987, *604149, *601929, *600910, *600900, *600864, *604165, *600782, *602836, *600769, *600742, *602783, *601905, *600535,
  • *604198, *601901, *600534, *602876, *603356, *600530, *604216, *604217, *602890, *602905, *600465, *600464, *600446, *602891, *603366, *601894, *604272, *603926, *603312, *600368, *602914, *600327, *603151, *603202, 602911, *602974, *603006, *601883, *603008, *600074, *603007, *603046, #603903, *604433, *600016, *603925, *516005, *516004, *516003, *601756,
  • *604487, *516001, *313475, *313470, #307810, *604527, *604528, *601745, *604551, *604555, *603243, *603242, *603061, *603063, *603217, *300335, *300283, *300281, *604600, *300197, *603097, *603220, *601625, *604623, *603118, *601590, *604646, *300008, *601568, *300007, *275630, *601533, #275200, *270200, #261550, *604031, *604683, #254800, *251100, #242300,
  • *604058, *604720, *240500, *233690, #232240, #226730, *223100, *222100, #220100, *216950, *604832, 212750, 212067, *604066, *193067, 601315, *193001, *604862, *604870, *191306, *600385, *604879, *191191, *601296, *604914, *190181, *604119, #188550, *604925, *188410, #601287, *604939, *188380, *604126, *604945, *604148, *188060, *604982, *186854, *604988,
  • *186360, *186355, *185250, *600916, *605008, *605009, 185020, *600734, *605024, *182331, *605032, *605033, *182305, *180903, #179800, *179610, *605060, *179410, *178990, *176802, *605080, *176266, *176263, *176260, *600732, *173490, *604199, *173445, *173391, 172290, *605147, *605149, *171890, *600528, *171833, *605185, #170500, *605193, #168000, *605196,
  • *167055, *605205, *605208, 166900, *605216, *162651, *162010, *600504, #161400, *604253, #160800, *159460, *154540, *605254, *605261, *153634, *600429, *153337, *600424, *605292, #604286, #152700, 152423, *152310, *151625, *600153, *604313, *151523, *150325, *150320, *150292, *603150, *150290, *150210, *605410, *605415, *605416, *605417, *605421, *603149,
  • *604349, *147940, *600282, *147880, *146928, *146661, *600150, *146630, *142622, *600018, *605461, *138981, *138590, *600023, *138330, *605495, *138297, *605512, *138230, #136900, #301310, *516006, *605545, *605546, *136131, *134660, *134350, *516002, *605589, *131235, #130050, *605625, *126455, *126064, #125310, *605670, *604534, *125240, *123836, *123830,
  • *123620, *605702, #122200, *120980, *120360, *118510, *114835, *605710, *605716, *605722, *114217, *604561, *113810, *111740, #110800, *605748, *605752, *604564, *110600, *603160, *109610, *605784, #107480, *107273, *603192, *300169, *106195, *105210, *104615, *104614, *104210, *103850, 103581, *605876, *605877, *605879, *103220, *605887, *300150, *102910,
  • *102670, *102576, *605916, *604629, *102575, *102573, *300132, *101800, *605947
  • 3) Channel (Member of Membrane Protein)
  • 361 entries found, searching for “channel”
  • *176266, *600724, *182390, *123825, *114208, *114206, *176267, *114205, *601784, *600937, *114204, *603415, *600053, *114207, *114209, *605427, *604527, *604528, *600760, *601011, *192500, *118425, *600228, *176261, *602235, *600761, *600359, *300008, *182389, *600877, *602232, *176263, *182391, *601328, *600054, *603939, *602208, *601534, *600504, *602323,
  • *603208, *601958, *603537, *601012, *601327, *600734, *602780, *602781, *604433, *603220, *182392, *605874, *605873, *601745, *603888, *603219, *602604, *603796, *302910, *602866, *601013, *602905, *602906, *603967, *600163, #170500, *152427, *180901, *176260, #601462, *603951, *601141, *604492, *600702, *602023, *600308, *602754, *107776, *176257, *602024,
  • *601949, *605222, *601142, *602983, *193245, *600681, *176265, *600235, *176262, *176258, *605206, *604427, *605411, *603305, *601219, *600150, *604065, *602343, *605223, *605720, *603906, *138249, *138253, *600843, *604385, *600003, *600935, *603940, *602727, *602158, 602911, *600397, *602726, *600845, *605080, *600580, *602872, *602106, *176264, *603953,
  • *605722, *300110, *138252, *604111, *602717, *602420, *600570, 600844, *603493, *600932, *605716, *138254, *603652, *300138, *605410, *176268, *605214, *605696, *300334, *604660, *176256, *605879, *603749, *603583, *602345, *604661, *603787, 603313, *602982, *604337, *600846, *604662, *300328, *300281, *602566, *602836, *604003, *603788, *603651, *602421,
  • *107777, #177200, *100725, #219700, *100690, *100710, #160800, #603830, #183086, *600509, #220400, #601144, *173910, *180902, *605692, #264350, #160900, #145600, #255700, *602076, *603061, *601313, *154275, #604233, *604532, #108500, #121201, #170400, *300225, *121014, *139311, #125800, #160120, *118503, 601439, #141500, #168300, *304040, #601887, #256450,
  • *186945, *154276, #300009, #216900, *600040, *601014, *601042, *602512, *601383, *605445, *602368, *603831, #117000, *601218, *108745, *605248, #177735, #173900, *601212, *182139, *601059, *600039, *601485, *180903, *186360, *603319, #600101, *118509, *600109, #121200, *600170, *604187, *176975, *137163, #310468, #263800, #262300, *603750, *600229, *124030,
  • *602251, #603829, *137143, #145500, *600669, *147450, *154050, *603353, *600516, *601157, *600855, *601154, *602522, *249210, *600968, #252650, *171060, *600919, *156490, #259700, #601678, *601764, #310500, *131244, *300041, *121011, *125950, *114180, *602974, *600637, *113730, *118504, *605145, *604669, *118800, *121013, *121015, *138491, *600421, *104610,
  • *604045, *604594, *131230, *605487, *138247, *600467, #602485, *602481, *138251, *137192, *602403, 600851, *277900, *603785, *603152, *603199, *603475, #168600, #272120, *170280, *603852, #241200, *603053, *600465, #603034, *142461, *164920, *137164, *600884, *600442, *123885, *604001, *600232, *232200, *171050, *602103, *602014, *300211, *600983, *602887,
  • *604415, *604418, *300242, #300071, *604471, *600837, 168350, *118511, 193007, *600300, *604654, #601820, *180297, *600046, *603853, *604678, *604693, #604772, *118508, *603855, *605204, #254210, *182099, *182307, #130600, *601109, *114080, *300103, *182860, *605438, *601129, *603964, *600019, *516060, #185000, *138079, *104210, *605818, *603418, *305990, *305450
  • 4) Extracellular Matrix
  • 218 entries found, searching for “extracellular matrix”
  • *605912, *603479, *602201, *604633, *601418, *601548, *115437, *154870, *600754, *602261, *602285, *602262, *134797, *120361, *604629, *604871, *603321, *603320, *601807, #154700, *116935, *185261, *120360, *185250, *605470, *603767, *253700, *190180, *128239, *308700, *276901, *193300, *120324, *188826, *602109, *155760, *600514, *600261, #177170, *600536,
  • *147557, #116920, *150240, *601313, *120140, 601614, *605158, *120150, *120180, #200610, *605127, *193400, *192240, #173900, *152200, #136900, *135821, #130070, *120320, *120220, *112260, *310200, *600900, *600262, *605670, *600985, *179590, #245150, *602574, *601463, 183850, *601211, *604241, *600758, *186745, *604710, *602369, *602090, *190182, *192975,
  • *602178, *230740, *600065, *601652, *158106, *190181, *156790, #158810, *193210, *155120, *192977, *193065, #226700, *187380, *231050, *182120, *188060, *186355, 163200, *164010, #156550, *151510, *150370, *253800, *156225, *150325, #194050, *150290, *216550, *147620, *600215, *222600, *147559, *165380, *182888, *600491, *146650, *146640, *600564, *600596,
  • *600616, *600700, *600742, *138297, *182889, *154705, *600930, *301870, *153619, *601050, *601090, *601105, *165070, *305370, *135820, *130660, *310300, *601492, *128240, *601587, #126600, *601636, *600119, *601692, *601728, *125485, 601858, *601915, *602048, *175100, *602108, *121010, *600245, *120470, *120328, *120325, *602264, *120280, *602366, *600309,
  • *602402, *602415, *602428, *602453, *602505, #166210, *602600, *602941, *603005, *603196, 603209, *603221, *603234, *603319, *120250, *120210, *120120, *603489, *603551, *118938, *603799, *603842, *603924, *603963, *604042, *604063, *604149, *604160, *601028, *604467, *604510, *604592, *116930, *116806, *601284, *604724, *604806, *604807, *604808, *107269,
  • *605007, *605008, *605009, *600214, *600076, *605174, *605175, *605292, *605343, *605351, #600204, *605497, *605546, *605587, *605623, *600211, *605702, *103320
  • In addition to these, the various keywords shown in the above-mentioned categorization or others can be used for the OMIM search and the result may suggest the involvement thereof in diseases.
  • Further, the use of nucleotide sequences of cDNAs of the present invention enables analyzing the expression frequency of genes corresponding to the cDNAs. In addition, functions of the genes can be predicted based on the information obtained by the expression frequency analysis.
  • There are several methods for analyzing the expression levels of genes involved in diseases. Differences in gene expression levels between diseased and normal tissues are studied by the analytical methods using, for example, Northern hybridization, RT-PCR, DNA microarray, etc. (Experimental Medicine, Vol. 17, No. 8, 980-1056 (1999); Cell Engineering (additional volume) DNA Microarray and Advanced PCR Methods, Muramatsu & Nawa (eds.), Shujunsya (2000)). By computer analysis, in addition to these analysis methods, the nucleotide sequences of expressed genes can be compared to analyze the expression frequency. For example, there is a database called “BODYMAP”; gene clones are extracted at random from cDNA libraries of various tissues and/or cells, and the clones homologous to one another are assigned to a single cluster based on the information of nucleotide sequence homology at the 3′-end; genes are classified into any clusters, and the numbers of clones in the respective clusters are compared to gain the information on expression frequency (http://bodymap.ims.utokyo.ac.jp/).
  • When explicit difference in the expression levels between diseased tissues and normal tissues is observed for a gene by these analytical methods, it can be conclude that the gene is closely involved in a disease or disorder. Instead of diseased tissues, when gene expression is explicitly different between normal cells and cells reproducing disease-associated specific features, it can be concluded that the gene is closely involved in a disease or disorder.
  • From the 2443 clones whose full-length nucleotide sequences had been revealed, genes involved in particular pathology or functions were selected by the use of databases shown below (see Example 7; “Expression frequency analysis in silico”). The database used in the analyses of the present invention contains nucleotide sequences of 1,402,070 clones, and the population of the database is large enough for the analysis. The sequence information in the database was obtained by selecting cDNA clones at random from cDNA libraries derived from the various tissues and cells shown in Example 1 and determining the 5′-end sequences thereof.
  • Then, the nucleotide sequences of respective clones in this database were categorized (clustered) based on the nucleotide sequence homology determined with a search program; the number of clones belonging to every cluster of each library was determined and normalized; thus, the ratio of a certain gene in a cDNA library was determined. This analysis provided the information of the expression frequency of a gene in a tissue or cell that is the source of the cDNA library.
  • Then, in order to analyze the expression of genes corresponding to the nucleotide sequences of cDNAs of the present invention in tissues and cells, the libraries from the tissues or cells, which had been used in the large-scale cDNA analyses, were taken as subjects to compare the expression levels between different tissues or cells. Namely, the expression frequency was analyzed by comparing the previously normalized values between tissues or cells from which 600 or more cDNA clones whose nucleotide sequences had been analyzed were derived. The result of this analysis showed that the cDNA clones corresponded to the genes involved in the pathology and functions, which are indicated below. Each value in Tables 3 to 51 indicated below represents a relative expression frequency; the higher the value, the higher the expression level.
  • Osteoporosis-Related Genes
  • Osteoporosis is a pathology in which bones are easily broken owing to overall decrease in components of bone. The onset correlates to the balance between the functions of osteoblast producing bone and osteoclast absorbing bone, namely bone metabolism. Thus, the genes involved in the increase of osteoclasts differentiating from precursor cells of monocyte/macrophage line (Molecular Medicine 38. 642-648. (2001)) are genes involved in osteoporosis relevant to bone metabolism.
  • A nucleotide sequence information-based analysis was carried out to identify the genes whose expression frequencies are higher or lower in CD34+ cell (cell expressing a glycoprotein CD34) treated with the osteoclast differentiation factor (Molecular Medicine 38. 642-648. (2001)) than in the untreated CD34+ cell, which is the precursor cell of monocyte/macrophage line. The result of comparative analysis for the frequency between the cDNA libraries prepared from the RNA of CD34+ cells (CD34C) and from the RNA of CD34+ cells treated with the osteoclast differentiation factor (D30ST, D60ST or D90ST) showed that the genes whose expression levels were different between the two were 56 clones indicated in Table 3. These clones are involved in osteoporosis.
  • Genes Involved in Neural Cell Differentiation
  • Genes involved in neural cell differentiation are useful for treating neurological diseases. Genes with varying expression levels in response to induction of cellular differentiation in neural cells are thought to be involved in neurological diseases.
  • A survey was performed for genes whose expression levels are varied in response to induction of differentiation (stimulation by retinoic acid (RA) or growth inhibitor treatment after RA stimulation) in cultured cells of a neural strain, NT2. The result of comparative analysis of cDNA libraries derived from undifferentiated NT2 cells (NT2RM) and the cells subjected to the differentiation treatment (NT2RP, NT2R1 or NT2NE) showed that the genes whose expression levels were different between the two were 288 clones indicated in Table 4. These genes are neurological disease-related genes.
  • Cancer-Related Genes
  • It has been assumed that, distinct from normal tissues, cancer tissues express a distinct set of genes, and thus the expression thereof can contribute to the carcinogenesis in tissues and cells. Thus, genes whose expression patterns in cancer tissues are different from those in normal tissues are cancer-related genes. Search was carried out for the genes whose expression levels in cancer tissues were different from those in normal tissues.
  • The result of comparative analysis of cDNA libraries derived from breast tumor (TBAES) and normal breast (BEAST) showed that the genes whose expression levels were different between the two were 35 clones indicated in Table 5.
  • The result of comparative analysis of cDNA libraries derived cervical tumor (TCERX) and normal cervical duct (CERVX) showed that the genes whose expression levels were different between the two were 11 clones indicated in Table 6.
  • The result of comparative analysis of cDNA libraries derived from colon tumor (TCOLN) and normal colon (COLON) showed that the genes whose expression levels were different between the two were 25 clones indicated in Table 7.
  • The result of comparative analysis of cDNA libraries derived from esophageal tumor (TESOP) and normal esophagus (NESOP) showed that the genes whose expression levels were different between the two were 41 clones indicated in Table 8.
  • The result of comparative analysis of cDNA libraries derived from kidney tumor (TKIDN) and normal kidney (KIDNE) showed that the genes whose expression levels were different between the two were 175 clones indicated in Table 9.
  • The result of comparative analysis of cDNA libraries derived from liver tumor (TLIVE) and normal liver (LIVER) showed that the genes whose expression levels were different between the two were 47 clones indicated in Table 10.
  • The result of comparative analysis of cDNA libraries derived from lung tumor (TLUNG) and normal lung (HLUNG) showed that the genes whose expression levels were different between the two were 62 clones indicated in Table 11.
  • The result of comparative analysis of cDNA libraries derived from ovary tumor (TOVER) and normal ovary (NOVER) showed the genes whose expression levels were different between the two were 23 clones indicated in Table 12.
  • The result of comparative analysis of cDNA libraries derived from stomach tumor (TSTOM) and normal stomach (STOMA) showed that the genes whose expression levels were different between the two were 70 clones indicated in Table 13.
  • The result of comparative analysis of cDNA libraries derived from uterine tumor (TUTER) and normal uterus (UTERU) showed that the genes whose expression levels were different between the two were 236 clones indicated in Table 14.
  • The result of comparative analysis of cDNA libraries derived from tongue cancer (CTONG) and normal tongue (NTONG) showed that the genes whose expression levels were different between the two were 232 clones indicated in Table 15.
  • These genes are involved in cancers.
  • Further, there is a method to search for genes involved in development and differentiation, which is the expression frequency analysis in which the expression levels of genes are compared between developing and/or differentiating tissues and/or cells and adult tissues and/or cells. The genes involved in tissue development and/or differentiation are genes participating in tissue construction and expression of function, and thus are useful genes, which are available for regenerative medicine aiming at convenient regeneration of injured tissues.
  • By using the information of gene expression frequency gained from the database of 5′-end nucleotide sequences described above, genes involved in development or differentiation of particular tissues were selected from the 2443 clones whose full-length nucleotide sequence had been revealed (see Example 7).
  • The result of comparative analysis of cDNA libraries derived from fetal brain (FCBBF, FEBRA or OCBBF) and adult brain (BRACE, BRALZ, BRAMY, BRAWH, BRCAN, BRCOC, BRHIP, BRSSN, BRSTN or BRTHA) showed that the genes whose expression levels were different between the two were 1195 clones indicated in Tables 16 to 48.
  • The result of comparative analysis of cDNA libraries derived from fetal heart (FEHRT) and adult heart (HEART) showed that the genes whose expression levels were different between the two were 45 clones indicated in Table 49.
  • The result of comparative analysis of cDNA libraries derived from fetal kidney (FEKID) and adult kidney (KIDNE) showed that the genes whose expression levels were different between the two were 118 clones indicated in Table 50.
  • The result of comparative analysis of cDNA libraries derived from fetal lung (FELNG) and adult lung (HLUNG) showed that the genes whose expression levels were different between the two were 63 clones indicated in Table 51. These genes are involved in regeneration of tissues and/or cells.
  • The expression frequency or the like can be analyzed by PCR based on the nucleotide sequences of cDNAs of the present invention. There are some known methods for comparing the quantities of amplification products obtained by PCR. For example, the band intensities can be determined by ethidium bromide staining. With R1-labeled or fluorescently labeled primers, the R1 signal or fluorescence intensity can be assayed for the quantity of labeled amplification products. Alternatively, the quantity of amplification products can also be determined by measuring the R1 signal or the fluorescence intensity from the R1-labeled or fluorescently labeled probe hybridizing to the products. The assay results thus obtained are compared and then the clones exhibiting differences in the expression levels can be selected.
  • There are some quantitative PCR methods: a PCR method using internal standards; a competitive PCR, in which the quantification is achieved by adding, to a sample, a dilution series of a known quantity of a template RNA and by comparing the quantity of an amplification product derived from the RNA of interest with the quantity of an amplification product derived from the template RNA. These methods overcome the problems of errors in the amount of amplification products among tubes and of the plateau effect. ATAC-PCR (Adaptor-tagged competitive PCR) is a method of competitive PCR which is practiced by using multiple adapters of different sizes attached to a gene whose 3′-end nucleotide sequence has previously been determined. The ratio of expression frequency of a single mRNA species from a number of tissues (cells) can be assayed in a single step (Nucleic Acids Research 1997, 25(22): 4694-4696; “DNA Micro-array and Advanced PCR Techniques”, Cell Technology, supplement, Eds., Muramatsu and Nawa (Shujunsha, 2000): 104-112).
  • If it is observed, by using these analytical methods, that the expression levels of genes are evidently varied during major cellular events (such as differentiation and apoptosis), the genes are involved in the cellular events and accordingly are candidates for disease- and/or disorder-related genes. Further, genes exhibiting tissue-specific expression are genes playing important parts in the tissue functions and, therefore, can be candidates for genes involved in diseases and/or disorders affecting the tissues.
  • For example, inflammation is an important biological response that is known to be involved in various diseases. The representative inflammation-inducing factors include TNF-a (Tumor Necrosis Factor-alpha). There exists a signaling cascade activated by TNF-α stimulations, wherein NF-κB is a transducing molecule (Cell 1995, 80:529-532). It has also been revealed that many inflammation-related genes, including IL-2, IL-6 and G-CSF, are varied in the expression levels thereof in response to the signal through the pathway (Trends Genet. 1999, 15(6): 229-235). It is assumed that genes whose expression levels are varied in response to the stimulation of TNF-α also participate in inflammation.
  • Further, the infection of Helicobacter pylori to the gastric epithelia is known to cause gastritis and gastroduodenal ulcer (Mebio 2000, July, 17(7): 16-33). Thus, the genes whose expression levels are altered depending on co-culturing cells with Helicobacter pylori may be involved in gastritis and gastroduodenal ulcer. A recent study has suggested that Helicobacter pylori strongly activates the NF-KB pathway(Gastroenterology 2000, 119: 97-108).
  • THP-1 cell, which is a human monocyte cell line, was cultured in the presence of TNF-α (Tumor Necrosis Factor-alpha) The genes whose expression levels were altered owing to the presence of TNF-α were searched for, and the result showed that the clones whose expression levels were increased owing to the presence of TNF-α were ASTRO20152140, BRACE20057620,
  • BRACE20060720, BRACE20090440, BRACE20152870, BRACE20229280, BRAMY20002770, BRAMY20266850, BRAMY20280720, BRAWH20106180, BRAWH20122770, BRHIP20096170, BRHIP20111200, BRHIP20186120, BRHIP20194940, BRHIP20207430, BRSSN20152380, CTONG20095270, CTONG20100240, CTONG20158150,
  • CTONG20265130, D3OST20006540, D9OST20031370, FCBBF20071860, FCBBF30251420, FCBBF30252520, FCBBF40001420, FEBRA20017050, FEBRA20082100, HCHON20011160, KIDNE20141190, KIDNE20163880, KIDNE20182690, LIVER10004790, LIVER20038540, LIVER20085800, MESAN20130220, MESAN20174170, NT2NE20158600, NT2RI20005750, NT2RP70110860, NT2RP70169110, NT2RP70175670, NT2RP70188710, PERIC20002140, PLACE60155130, PROST20120160, PROST20149250, PROST20161950, PUAEN20015260, SKNSH20080430, SMINT20051610, SMINT20060780, SMINT20161220, SMINT20163960, SPLEN20101190, SPLEN20157300, SPLEN20163560, SPLEN20214580, SPLEN20279950, STOMA20048520, TESTI20076850, TESTI20087620, TESTI20108720, TESTI20220100, TESTI20239510, TESTI20266740, TESTI20342430, TESTI20370020, TESTI20391210, TESTI20401020, TESTI20415640, THYMU20130890, THYMU20286290, TRACH20060150, TRACH20099340, UTERU20004240, UTERU20068990, UTERU20119060.
  • On the other hand, the clones whose expression levels were decreased owing to the presence of TNF-αwere ASTRO20032120,
  • ASTRO20084250, ASTRO20181690, BRACE20062640, BRACE20067430, BRACE20235400, BRALZ20018340, BRALZ20069760, BRALZ20075450, BRAMY20163270, BRAMY20204450, BRAMY20218670, BRAMY20229800, BRAWH10000930, BRAWH20107540, BRAWH20132190, BRAWH20158530, BRCAN20273340, BRHIP20105710, BRHIP20186120,
  • BRSSN20176820, CTONG20095290, DFNES20031920, FCBBF30033050, FCBBF30071520, FCBBF30083820, HCHON20008980, HCHON20022470, HHDPC20034390, KIDNE20028720, KIDNE20079440, KIDNE20127750, KIDNE20148900, LIVER20011130, MAMGL10000830, MESAN20127350, NT2NE20181650, NT2RI20023160, NT2RP70102350, NT2RP70157890, NTONG20029480, OCBBF20020830, OCBBF20041680, OCBBF20061720, OCBBF20127040, OCBBF20139260, OCBBF20178990, PEBLM20013120, PLACE60003480, PLACE60181070, PROST20151240, PUAEN20003740, PUAEN20011880, PUAEN20078980, PUAEN20085150, SKNSH20080430, SMINT20001760, SMINT20047810, SMINT20108530, SPLEN20158990, SPLEN20283650, STOMA20010250, STOMA20057820, TESTI20060400, TESTI20161970, TESTI20275620, TESTI20369690, TESTI20386230, TESTI20392250, TESTI20409440, TESTI20424730, THYMU20095960, THYMU20111180, THYMU20226600, THYMU20253250, THYMU20272490, TRACH20153810, UTERU20176130, UTERU20186740.
  • These clones are inflammation-related genes.
  • MKN45, which is a gastric cancer cell line, was co-cultured with Helicobacter pylori. The genes whose expression levels were altered owing to the presence of Helicobacter pylori were searched for, and the result showed that the clones whose expression levels were increased owing to the presence of Helicobacter pylori were ADRGL20067670, BLADE20004630,
  • BRACE20039040, BRACE20151320, BRACE20229280, BRACE20235400, BRALZ20058880, BRAMY20060920, BRAMY20184670, BRAMY20218670, BRAMY20229800, BRCAN20147880, BRHIP20196410, BRHIP30004880, BRSSN20187310, CD34C30004940, CTONG20265130, DFNES20031920, FCBBF30278630, FCBBF40001420,
  • HHDPC20095280, KIDNE20130450, LIVER20011130, LIVER20038540, NT2NE20172590, NT2RP70169110, OCBBF20085200, OCBBF20180840, PEBLM10000240, PLACE60003480, PROST20120160, PROST20151240, PUAEN20011880, SKMUS20031680, SKNSH20080430, SMINT20056210, SMINT20105000, SPLEN20019450, SPLEN20211570, STOMA20048520, TESTI20004890, TESTI20083940, TESTI20168480, TESTI20239510, TESTI20308600, TESTI20478010, UTERU20126880.
  • On the other hand, the clones whose expression levels were decreased owing to the presence of Helicobacter pylori were
  • ASTRO20032120, BRACE20090440, BRACE20114780, BRALZ20064740, BRAMY20002770, BRAMY20210400, BRAMY20215230, BRAMY20247280, BRAMY20267130, BRAWH20029630, BRAWH20100690, BRAWH20118230, BRCOC20105100, BRHIP20218580, BRSSN20046570, CTONG20138030, CTONG20146970, CTONG20158150, D3OST20037970, FCBBF30001840, FCBBF30033050, FEBRA20082100, HCHON20035130, HCHON20043590, HCHON20067220, NT2NE20174920, NT2RI20009870, NT2RI20023160, NT2RP70062230, NT2RP70130020, NTONG20070340, OCBBF20020150, OCBBF20094240, OCBBF20107920, PROST20144220, PROST20149160, PROST20153320, PUAEN20003740, PUAEN20025680, PUAEN20040670, SMINT20014580, SPLEN20101190, STOMA20076800, TESTI20087620, TESTI20098530, TESTI20123080, TESTI20161970, TESTI20234140, TESTI20288110, TESTI20357960, TESTI20391210, TESTI20424730, THYMU20158250, THYMU20226600, TRACH20005020, TRACH20134950, TRACH20184490, TSTOM20001390, UTERU20119060, UTERU20134910, UTERU20176130.
  • These clones are involved in gastritis or gastroduodenal ulcer.
  • For example, if the polypeptide encoded by the cDNA of the present invention is a regulatory factor of cellular conditions such as growth and differentiation, it can be used for developing medicines as follows. The polypeptide or antibody provided by the invention is injected into a certain kind of cells by microinjection. Then, using the cells, it is possible to screen low molecular weight compounds, etc. by measuring the change in the cellular conditions, or the activation or inhibition of a particular gene. The screening can be performed as follows.
  • First, the polypeptide is expressed and purified as recombinant. The purified polypeptide is microinjected into cells such as various cell lines, or primary culture cells, and the cellular change such as growth and differentiation can be examined. Alternatively, the induction of genes whose expression is known to be involved in a particular change of cellular conditions may be detected by the amount of mRNA or polypeptide. Alternatively, the amount of intracellular molecules (low molecular weight compounds, etc.) that is changed by the function of the gene product (polypeptide) which is known to be involved in a particular change of cellular conditions may be detected. The compounds to be screened (both low and high molecular compounds are acceptable) can be added to the culture media and assessed for their activity by measuring the change of the cellular conditions.
  • Instead of microinjection, cell lines introduced with the gene obtained in the invention can be used for the screening. If the gene product is turn out to be involved in a particular change in the cellular conditions, the change of the product can be used as a measurement for screening. Once a compound is screened out which can activate or inhibit the function of the polypeptide of the invention, it can be applied for developing medicines.
  • If the polypeptide encoded by the cDNA of the present invention is a secretory protein, membrane protein, or protein involved in signal transduction, glycoprotein, transcription, or diseases, it can be used in functional assays for developing medicines.
  • In case of a membrane protein, it is most likely to be a polypeptide that functions as a receptor or ligand on the cell surface. Therefore, it is possible to reveal a new relationship between a ligand and receptor by screening the membrane protein of the invention based on the binding activity with the known ligand or receptor. Screening can be performed according to the known methods.
  • For example, a ligand against the polypeptide of the invention can be screened in the following manner. Namely, a ligand that binds to a specific polypeptide can be screened by a method comprising the steps of: (a) contacting a test sample with the polypeptide of the invention or a partial peptide thereof, or cells expressing these, and (b) selecting a test sample that binds to said polypeptide, said partial peptide, or said cells.
  • On the other hand, for example, screening using cells expressing the polypeptide of the present invention that is a receptor protein can also be performed as follows. It is possible to screen receptors that is capable of binding to a specific polypeptide by using procedures (a) attaching the sample cells to the polypeptide of the invention or its partial peptide, and (b) selecting cells that can bind to the said polypeptide or its partial peptide.
  • In a following screening as an example, first the polypeptide of the invention is expressed, and the recombinant polypeptide is purified. Next, the purified polypeptide is labeled, binding assay is performed using a various cell lines or primary cultured cells, and cells that are expressing a receptor are selected (Growth and differentiation factors and their receptors, Shin-Seikagaku Jikken Kouza Vol. 7 (1991) Honjyo, Arai, Taniguchi, and Muramatsu edit, p203-236, Tokyo-Kagaku-Doujin). A polypeptide of the invention can be labeled with RI such as 125I, and enzyme (alkaline phosphatase etc.).
  • Alternatively, a polypeptide of the invention may be used without labeling and then detected by using a labeled antibody against the polypeptide. The cells that are selected by the above screening methods, which express a receptor of the polypeptide of the invention, can be used for the further screening of an agonists or antagonists of the said receptor.
  • Once the ligand binding to the polypeptide of the invention, the receptor of the polypeptide of the invention or the cells expressing the receptor are obtained by screening, it is possible to screen a compound that binds to the ligand and receptor. Also it is possible to screen a compound that can inhibit both bindings (agonists or antagonists of the receptor, for example) by utilizing the binding activities.
  • When the polypeptide of the invention is a receptor, the screening method comprises the steps of (a) contacting the polypeptide of the invention or cells expressing the polypeptide of the invention with the ligand, in the presence of a test sample, (b) detecting the binding activity between said polypeptide or cells expressing said polypeptide and the ligand, and (c) selecting a compound that reduces said binding activity when compared to the activity in the absence of the test sample. Furthermore, when the polypeptide of the invention is a ligand, the screening method comprises the steps of (a) contacting the polypeptide of the invention with its receptor or cells expressing the receptor in the presence of samples, (b) detecting the binding activity between the polypeptide and its receptor or the cells expressing the receptor, and (c) selecting a compound that can potentially reduce the binding activity compared to the activity in the absence of the sample.
  • Samples to screen include cell extracts, expressed products from a gene library, synthesized low molecular compound, synthesized peptide, and natural compounds, for example, but are not construed to be listed here. A compound that is isolated by the above screening using a binding activity of the polypeptide of the invention can also be used as a sample.
  • A compound isolated by the screening may be a candidate to be an agonist or an antagonist of the receptor of the polypeptide. By utilizing an assay that monitors a change in the intracellular signaling such as phosphorylation which results from reduction of the binding between the polypeptide and its receptor, it is possible to identify whether the obtained compound is an agonist or antagonist of the receptor. Also, the compound may be a candidate of a molecule that can inhibit the interaction between the polypeptide and its associated proteins (including a receptor) in vivo. Such compounds can be used for developing drugs for precaution or cures of a disease in which the polypeptide is involved.
  • Secretory proteins may regulate cellular conditions such as growth and differentiation. It is possible to find out a novel factor that regulates cellular conditions by adding the secretory protein of the invention to a certain kind of cell, and performing a screening by utilizing the cellular changes in growth or differentiation, or activation of a particular gene.
  • The screening can be performed, for example, as follows. First, the polypeptide of the invention is expressed and purified in a recombinant form. Then, the purified polypeptide is added to a various kind of cell lines or primary cultured cells, and the change in the cell growth and differentiation is monitored. The induction of a particular gene that is known to be involved in a certain cellular change is detected by the amounts of mRNA and polypeptide. Alternatively, the amount of an intracellular molecule (low-molecular-weight compounds, etc.) that is changed by the function of a gene product (polypeptide) that is known to function in a certain cellular change is used for the detection.
  • Once the screening reveals that the polypeptide of the invention can regulate cellular conditions or the functions, it is possible to apply the polypeptide as a pharmaceutical and diagnostic medicine for related diseases by itself or by altering a part of it into an appropriate composition.
  • As is above described for membrane proteins, the secretory protein provided by the invention may be used to explore a novel ligand-receptor interaction using a screening based on the binding activity to a known ligand or receptor. A similar method can be used to identify an agonist or antagonist. The resulting compounds obtained by the methods can be a candidate of a compound that can inhibit the interaction between the polypeptide of the invention and an interacting molecule (including a receptor). The compounds may be able to use as a preventive, therapeutic, and diagnostic medicine for the diseases, in which the polypeptide may play a certain role.
  • Proteins involved in signal transduction or transcription may be a factor that affects a certain polypeptide or gene in response to intracellular/extracellular stimuli. It is possible to find out a novel factor that can affect a polypeptide or gene by expressing the polypeptide provided by the invention in a certain types of cells, and performing a screening utilizing the activation of a certain intracellular polypeptide or gene.
  • The screening may be performed as follows. First, a transformed cell line expressing the polypeptide is obtained. Then, the transformed cell line and the untransformed original cell line are compared for the changes in the expression of a certain gene by detecting the amount of its mRNA or polypeptide. Alternatively, the amount of an intracellular molecule (low molecular weight compounds, etc.) that is changed by the function of a certain gene product (polypeptide) may be used for the detection. Furthermore, the change of the expression of a certain gene can be detected by introducing a fusion gene that comprises a regulatory region of the gene and a marker gene (luciferase, β-galactosidase, etc.) into a cell, expressing the polypeptide provided by the invention into the cell, and estimating the activity of a marker gene product (polypeptide).
  • If the polypeptide or gene of the invention is involved in diseases, it is possible to screen a gene or compound that can regulate its expression and/or activity either directly or indirectly by utilizing the polypeptide of the present invention.
  • For example, the polypeptide of the invention is expressed and purified as a recombinant polypeptide. Then, the polypeptide or gene that interacts with the polypeptide of the invention is purified, and screened based on the binding. Alternatively, the screening can be performed by adding with a compound of a candidate of the inhibitor added in advance and monitoring the change of binding activity. In another method, a transcription regulatory region locating in the 5′-upstream of the gene encoding the polypeptide of the invention that is capable of regulating the expression of other genes is obtained, and fused with a marker gene. The fusion is introduced into a cell, and the cell is added with compounds to explore a regulatory factor of the expression of the said gene.
  • The compound obtained by the screening can be used for developing pharmaceutical and diagnostic medicines for the diseases in which the polypeptide of the present invention is involved. Similarly, if the regulatory factor obtained in the screening is turn out to be a polypeptide, compounds that can newly affect the expression or activity of the polypeptide may be used as a medicine for the diseases in which the polypeptide of the invention is involved.
  • If the polypeptide of the invention has an enzymatic activity, regardless as to whether it is a secretory protein, membrane protein, or proteins involved in signal transduction, glycoprotein, transcription, or diseases, a screening may be performed by adding a compound to the polypeptide of the invention and monitoring the change of the compound. The enzymatic activity may also be utilized to screen a compound that can inhibit the activity of the polypeptide.
  • In a screening given as an example, the polypeptide of the invention is expressed and the recombinant polypeptide is purified. Then, compounds are contacted with the purified polypeptide, and the amount of the compound and the reaction products is examined. Alternatively, compounds that are candidates of an inhibitor are pretreated, then a compound (substrate) that can react with the purified polypeptide is added, and the amount of the substrate and the reaction products is examined.
  • The compounds obtained in the screening may be used as a medicine for diseases in which the polypeptide of the invention is involved. Also they can be applied for tests that examine whether the polypeptide of the invention functions normally in vivo.
  • Whether the secretory protein, membrane protein, signal transduction-related protein, glycoprotein-related protein, or transcription-related protein of the present invention is a novel protein involved in diseases or not is determined in another method than described above, by obtaining a specific antibody against the polypeptide of the invention, and examining the relationship between the expression or activity of the polypeptide and a certain disease. In an alternative way, it may be analyzed referred to the methods in “Molecular Diagnosis of Genetic Diseases” (Elles R. edit, (1996) in the series of “Method in Molecular Biology” (Humana Press).
  • Proteins involved in diseases are targets of screening as mentioned, and thus are very useful in developing drugs which regulate their expression and activity. Also, the proteins are useful in the medicinal industry as a diagnostic marker of the related disease or a target of gene therapy.
  • Compounds isolated as mentioned above can be administered patients as it is, or after formulated into a pharmaceutical composition according to the known methods. For example, a pharmaceutically acceptable carrier or vehicle, specifically sterilized water, saline, plant oil, emulsifier, or suspending agent can be mixed with the compounds appropriately. The pharmaceutical compositions can be administered to patients by a method known to those skilled in the art, such as intraarterial, intravenous, or subcutaneous injections. The dosage may vary depending on the weight or age of a patient, or the method of administration, but those skilled in the art can choose an appropriate dosage properly. If the compound is encoded by polynucleotide, the polynucleotide can be cloned into a vector for gene therapy, and used for gene therapy. The dosage of the polynucleotide and the method of its administration may vary depending on the weight or age of a patient, or the symptoms, but those skilled in the art can choose properly.
  • The present invention further relates to databases comprising at least a sequence of polynucleotide and/or polypeptide, or a medium recorded in such databases, selected from the sequence data of the nucleotide and/or the amino acids indicated in Table 1. The term “database” means a set of accumulated information as machine-searchable and readable information of nucleotide sequence. The databases of the present invention comprise at least one of the novel nucleotide sequences of polynucleotides provided by the present invention. The databases of the present invention can consist of only the sequence data of the novel polynucleotides provided by the present invention or can comprise other information on nucleotide sequences of known full-length cDNAs or ESTs. The databases of the present invention can be comprised of not only the information on the nucleotide sequences but also the information on the gene functions revealed by the present invention. Additional information such as names of DNA clones carrying the full-length cDNAs can be recorded or linked together with the sequence data in the databases.
  • The database of the present invention is useful for gaining complete gene sequence information from partial sequence information of a gene of interest. The database of the present invention comprises nucleotide sequence information of full-length cDNAs. Consequently, by comparing the information in this database with the nucleotide sequence of a partial gene fragment yielded by differential display method or subtraction method, the information on the full-length nucleotide sequence of interest can be gained from the sequence of the partial fragment as a starting clue.
  • The sequence information of the full-length cDNAs constituting the database of the present invention contains not only the information on the complete sequences but also extra information on expression frequency of the genes as well as homology of the genes to known genes and known polypeptides. Thus the extra information facilitates rapid functional analyses of partial gene fragments. Further, the information on human genes is accumulated in the database of the present invention, and therefore, the database is useful for isolating a human homologue of a gene originating from other species. The human homologue can be isolated based on the nucleotide sequence of the gene from the original species.
  • At present, information on a wide variety of gene fragments can be obtained by differential display method and subtraction method. In general, these gene fragments are utilized as tools for isolating the full-length sequences thereof. When the gene fragment corresponds to an already-known gene, the full-length sequence is easily obtained by comparing the partial sequence with the information in known databases. However, when there exists no information corresponding to the partial sequence of interest in the known databases, cDNA cloning should be carried out for the full-length cDNA. It is often difficult to obtain the full-length nucleotide sequence using the partial sequence information as an initial clue. If the full-length of the gene is not available, the amino acid sequence of the polypeptide encoded by the gene remains unidentified. Thus the database of the present invention can contribute to the identification of full-length cDNAs corresponding to gene fragments, which cannot be revealed by using databases of known genes.
  • The present invention has provided 2443 polynucleotides. As has not yet proceeded the isolation of full-length cDNA within the human, the invention has great significance. It is known that secretory proteins, membrane proteins, signal transduction-related proteins, glycoprotein-related proteins, transcription-related proteins, and so on are involved in many diseases. The genes and proteins involved in diseases are useful for developing a diagnostic marker or medicines for regulation of their expression and activity, or as a target of gene therapy.
  • In particular, cDNA assumed to encode secretory proteins, which were provided by this invention, are very important for the industry since the encoded proteins themselves are expected to be useful as pharmaceutical agents and many disease-related genes may be included in them. In addition, membrane proteins, signal transduction-related proteins, transcription-related proteins, disease-related proteins, and genes encoding them can be used as indicators for diseases, etc. These cDNA are also very important for the industry, which are expected to regulate the activity or expression of the encoded protein to treat diseases, etc.
  • Any patents, patent applications, and publications cited herein are incorporated by reference.
  • The invention is illustrated more specifically with reference to the following examples, but is not to be construed as being limited thereto.
    • EXAMPLE 1 Preparation of cDNA Library by Oligo-Capping
  • (1) Extraction and Purchase of mRNA
  • Total RNAs as mRNA sources were extracted from human tissues (shown below) by the method as described in the reference (J. Sambrook, E. F. Fritsch & T. Maniatis, Molecular Cloning Second edition, Cold Spring harbor Laboratory Press, 1989). Further, by the method as described in the reference (J. Sambrook, E. F. Fritsch & T. Maniatis, Molecular Cloning Second edition, Cold Spring harbor Laboratory Press, 1989), total RNAs as mRNA sources were extracted from human culture cells and human primary culture cells (shown below) which had been cultivated by the methods described in the catalogs.
  • The library names and the origins are indicated below in the order of “Library name: Origin”. When a library was prepared by the subtraction method, the item is followed by a description of how to prepare the subtracted library.
  • <Extraction of mRNA From Human Tissues>
  • NTONG: Normal tongue;
  • CTONG: Tongue cancer;
  • FCBBF: Fetal brain;
  • OCBBF: Fetal brain;
  • PLACE: Placenta;
  • SYNOV: Synovial membrane tissue (from rheumatioid arthritis);
  • CORDB: Cord blood.
  • <Extraction of mRNA from Culture Cells>
  • BNGH4: H4 cells (ATCC #HTB-148);
  • IMR32: IMR32 cells (ATCC #CCL-127);
  • SKNMC: SK-N-MC cells (ATCC #HTB-10);
  • 3NB69: NB69 cells (RCB #RCB0480);
  • BGGI1: GI1 cells (RCB #RCB0763);
  • NB9N4: NB9 cells (RCB #RCB0477);
  • SKNSH: SK-N-SH cells (RCB #RCB0426);
  • AHMSC: Human mesenchymal (HMSC) cells;
  • CHONS: Chondrocytes;
  • ERLTF: TF-1 cells (erythroleukemia);
  • HELAC: HeLa cells;
  • JCMLC: Leukemia, myelogenous;
  • MESTC: Mesenchyme stem cells;
  • N1ESE: Mesenchymal stem cells;
  • NCRRM: Embryonal carcinoma;
  • NCRRP: Embryonal carcinoma treated with retinoic acid (RA) to induce the differentiation;
  • T1ESE: Mesenchymal stem cells treated with trichostatin and 5-azacytidine to induce the differentiation;
  • NT2RM: NT2 cells (STARATAGENE #204101);
  • NT2RP: NT2 cells treated with retinoic acid (RA) for 5 weeks to induce the differentiation;
  • NT2R1: NT2 cells treated with RA for 5 weeks to induce the differentiation, followed by the treatment with the growth inhibitor for 2 weeks;
  • NT2NE: NT2 cells were treated with RA and the growth inhibitor for the neuronal differentiation, and the resultant neurons were concentrated and harvested (NT2 Neuron);
  • NTISM: NT2 cells (STARATAGENE #204101) were treated with RA for 5 weeks to induce the differentiation, and then treated with the growth inhibitor for 2 weeks; mRNA was prepared from the cells and a cDNA library was constructed from the mRNA; the cDNAs of the library whose nucleotide sequences were shared by those of mRNAs from undifferentiated NT2 cells were subtracted by using a Subtract Kit (Invitrogen #K4320-01); the subtracted library (NT2R1-NT2RM) was provided by this procedure.
  • RCB indicates that the cell was provided by the Cell Bank, RIKEN GENE BANK, The Institute of Physical and Chemical Research; ATCC indicates that the cell was provided by American Type Culture Collection.
  • <Extraction of mRNA from Primary Culture Cells>
  • ASTRO: Normal human astrocyte NHA5732, Takara Shuzo #CC2565;
  • DFNES: Normal human dermal fibroblast (neonatal skin); NHDF-Neo
  • NHDF2564, Takara Shuzo #CC2509;
  • MESAN: Normal human mesangial cell NHMC56046-2, Takara Shuzo #CC2559;
  • NHNPC: Normal human neural progenitor cell NHNP5958, Takara Shuzo #CC2599;
  • PEBLM: Normal human peripheral blood mononuclear cell HPBMC5939, Takara Shuzo #CC2702;
  • HSYRA: Human synoviocyte HS-RA (from rheumatioid arthritis), Toyobo #T404K-05;
  • PUAEN: Normal human pulmonary artery endothelial cells, Toyobo #T302K-05;
  • UMVEN: Normal human umbilical vein endothelial cell HUVEC, Toyobo #T200K-05;
  • HCASM: Normal human coronary artery smooth muscle cell HCASMC, Toyobo #T305K-05;
  • HCHON: Normal human chondrocyte HC, Toyobo #T402K-05;
  • HHDPC: Normal human dermal papilla cell HDPC, Toyobo #THPCK-001;
  • CD34C: CD34+ cells (AllCells, LLC #CB14435M);
  • D3OST: CD34+ cells treated with the osteoclast differentiation factor (ODF) for 3 days to induce the differentiation;
  • D6OST: CD34+ cells treated with ODF for 6 days to induce the differentiation;
  • D9OST: CD34+ cells treated with ODF for 9 days to induce the differentiation;
  • ACTVT: Activated T-cells;
  • LYMPB: Lymphoblasts, EB virus transferred B cells;
  • NETRP: Neutrophils.
  • Then, total RNAs extracted from the following human tissues were purchased and used as mRNA sources. The library names and the origins are indicated below in the order of “Library name: Origin”. When a library was prepared by the subtraction method, the item is followed by a description of how to prepare the subtracted library.
  • <Purchase of Total RNA Containing mRNA Extracted From Human Tissues>
  • ADRGL: Adrenal gland, CLONTECH #64016-1;
  • BRACE: Brain (cerebellum), CLONTECH #64035-1;
  • BRAWH: Whole brain, CLONTECH #64020-1;
  • FEBRA: Fetal brain, CLONTECH #64019-1;
  • FELIV: Fetal liver, CLONTECH #64018-1;
  • HEART: Heart, CLONTECH #64025-1;
  • HLUNG: Lung, CLONTECH #64023-1;
  • KIDNE: Kidney, CLONTECH #64030-1;
  • LIVER: Liver, CLONTECH #64022-1;
  • MAMGL: Mammary Gland, CLONTECH #64037-1;
  • PANCR: Pancreas, CLONTECH #64031-1;
  • PROST: Prostate, CLONTECH #64038-1;
  • SALGL: Salivary Gland, CLONTECH #64026-1;
  • SKMUS: Skeletal Muscle, CLONTECH #64033-1;
  • SMINT: Small Intestine, CLONTECH #64039-1;
  • SPLEN: Spleen, CLONTECH #64034-1;
  • STOMA: Stomach, CLONTECH #64090-1;
  • TBAES: Breast (Tumor), CLONTECH #64015-1;
  • TCERX: Cervix (Tumor), CLONTECH #64010-1;
  • TCOLN: Colon (Tumor), CLONTECH #64014-1;
  • TESTI: Testis, CLONTECH #64027-1;
  • THYMU: Thymus, CLONTECH #64028-1;
  • TLUNG: Lung (Tumor), CLONTECH #64013-1;
  • TOVAR: Ovary (Tumor), CLONTECH #64011-1;
  • TRACH: Trachea, CLONTECH #64091-1;
  • TUTER: Uterus (Tumor), CLONTECH #64008-1;
  • UTERU: Uterus, CLONTECH #64029-1;
  • ADIPS: Adipose, Invitrogen #D6005-01;
  • BLADE: Bladder, Invitrogen #D6020-01;
  • BRALZ: Cerebral cortex from an Alzheimer patient (Brain, cortex, Alzheimer), Invitrogen #D6830-01;
  • CERVX: Cervix, Invitrogen #D6047-01;
  • COLON: Colon, Invitrogen #D6050-0;
  • NESOP: Esophagus, Invitrogen #D6060-01;
  • PERIC: Pericardium, Invitrogen #D6105-01;
  • RECTM: Rectum, Invitrogen #D6110-01;
  • TESOP: Esophageal (Tumor), Invitrogen #D6860-01;
  • TKIDN: Kidney (Tumor), Invitrogen #D6870-01;
  • TLIVE: Liver (Tumor), Invitrogen #D6880-01;
  • TSTOM: Stomach (Tumor), Invitrogen #D6920-01;
  • BEAST: Adult breast, STARATAGENE #735044;
  • FEHRT: Fetal heart, STARATAGENE #738012;
  • FEKID: Fetal kidney, STARATAGENE #738014;
  • FELNG: Fetal lung, STARATAGENE #738020;
  • NOVAR: Adult ovary, STARATAGENE #735260;
  • BRASW: subtracted library (BRALZ-BRAWH). A cDNA library was constructed from mRNA prepared from tissues of cerebral cortex obtained from an Alzheimer patient [BRALZ: Cerebral cortex from an Alzheimer patient (Brain, cortex, Alzheimer), Invitrogen #D6830-01]; the cDNAs of this library whose nucleotide sequences were shared by those of mRNAs from whole brain tissue [BRAWH: Whole brain, CLONTECH #64020-1] were subtracted by using a Subtract Kit (Invitrogen #K4320-01).
  • Further, mRNAs extracted and purified as poly A(+) RNAs from the human tissues shown below were purchased. A cDNA library was prepared from an RNA mixture in which the poly A(+) RNA from each tissue had been combined with poly A(−) RNA. The poly A(−) RNA was prepared by removing poly A(+) RNA from the total RNA of whole brain tissue (CLONTECH #64020-1) by using oligo dT cellulose. The library names and the origins are indicated below in the order of “Library name: Origin”.
  • <Purchase of mRNAs of Human Tissues as Poly A(+) RNAs>
  • BRAMY: Brain (amygdala), CLONTECH #6574-1;
  • BRCAN: Brain (caudate nucleus), CLONTECH #6575-1;
  • BRCOC: Brain (corpus callosum), CLONTECH #6577-1;
  • BRHIP: Brain (hippocampus), CLONTECH #6578-1;
  • BRSSN: Brain (substantia nigra), CLONTECH #6580-1;
  • BRSTN: Brain (subthalamic nucleus), CLONTECH #6581-1;
  • BRTHA: Brain (thalamus), CLONTECH #6582-1.
  • (2) Preparation of cDNA Library
  • cDNA library was prepared from each RNA by the improved method (WO 01/04286) of oligo capping [M. Maruyama and S. Sugano, Gene, 138: 171-174 (1994)]. A series of procedures, BAP (Bacterial Alkaline Phosphatase) treatment, TAP (Tobacco Acid Pyrophosphatase) treatment, RNA ligation, first strand cDNA synthesis and RNA removal, were carried out using the oligo-cap linker (SEQ ID NO: 5455) and oligo dT primer (SEQ ID NO: 5456), as described in WO 01/04286. Then, the single-stranded cDNA was converted to a double-stranded cDNA by PCR (polymerase chain reaction) using 5′ (SEQ ID NO: 5457) and 3′ (SEQ ID NO: 5458) PCR primers, and then digested with SfiI. Then, a fraction of cDNA fragments, typically 2-kb or longer (3-kb or longer in some cases), was unidirectionally cloned into a DraIII-digested pME18SFL3 vector (FIG. 1) (GenBank AB009864, Expression vector); the cDNA library was thus prepared.
  • The names of cDNA libraries, which were used in the analysis of full-length cDNA sequences, and their origins are shown in Table 2.
    TABLE 2
    Library Type Origin, etc.
    3NB69 Culture cell NB69 cells (RCB #RCB0480)
    ADIPS Tissue Adipose (Invitrogen #D6005-01)
    ADRGL Tissue Adrenal gland (CLONTECH #64016-1)
    ASTRO Primary culture cell Normal Human Astrocyte NHA5732 (Takara Shuzo
    #CC2565)
    BEAST Tissue Adult Breast (STARATAGENE #735044)
    BGGI1 Culture cell GI1 cells (RCB #RCB0763)
    BLADE Tissue Bladder (Invitrogen #D6020-01)
    BNGH4 Culture cell H4 cells (ATCC #HTB-148)
    BRACE Tissue Brain, cerebellum (CLONTECH #64035-1)
    BRALZ Tissue Brain, cortex, Alzheimer (Invitrogen #D6830-01)
    BRAMY Tissue Brain, amygdala (CLONTECH #6574-1)
    BRAWH Tissue Brain, whole (CLONTECH #64020-1)
    BRCAN Tissue Brain, caudate nucleus (CLONTECH #6575-1)
    BRCOC Tissue Brain, corpus callosum (CLONTECH #6577-1)
    BRHIP Tissue Brain, hippocampus (CLONTECH #6578-1)
    BRSSN Tissue Brain, substantia nigra (CLONTECH #6580-1)
    BRSTN Tissue Brain, subthalamic nucleus (CLONTECH #6581-1)
    BRTHA Tissue Brain, thalamus (CLONTECH #6582-1)
    CD34C Primary culture cell CD34+ cells (AllCells, LLC #CB14435M)
    COLON Tissue Colon (Invitrogen #D6050-0)
    CTONG Tissue Tongue, Cancer
    D3OST Primary culture cell CD34+ cells (ODF induction for 3 days)
    D6OST Primary culture cell CD34+ cells (ODF induction for 6 days)
    D9OST Primary culture cell CD34+ cells (ODF induction for 9 days)
    DFNES Primary culture cell Normal Human Dermal Fibroblasts (Neonatal Skin);
    NHDF-Neo NHDF2564 (Takara Shuzo #CC2509)
    FCBBF Tissue Brain, Fetal
    FEBRA Tissue Brain, Fetal (CLONTECH #64019-1)
    FEHRT Tissue Heart, Fetal (STARATAGENE #738012)
    FELNG Tissue Lung, Fetal (STARATAGENE #738020)
    HCASM Primary culture cell Human coronary artery smooth muscle cells HCASMC
    (Toyobo #T305K-05)
    HCHON Primary culture cell Human Chondrocytes HC (Toyobo #T402K-05)
    HEART Tissue Heart (CLONTECH #64025-1)
    HHDPC Primary culture cell Human dermal papilla cells HDPC (Toyobo #THPCK-
    001)
    HLUNG Tissue Lung (CLONTECH #64023-1)
    IMR32 Culture cell IMR32 cells (ATCC #CCL-127)
    KIDNE Tissue Kidney (CLONTECH #64030-1)
    LIVER Tissue Liver (CLONTECH #64022-1)
    MAMGL Tissue Mammary Gland (CLONTECH #64037-1)
    MESAN Primary culture cell Normal human mesangial cells NHMC56046-2 (Takara
    Shuzo #CC2559)
    NESOP Tissue Esophagus (Invitrogen #D6060-01)
    NOVAR Tissue Adult Ovary (STARATAGENE #735260)
    NT2NE Culture cell NT2 cells concentrated after differenciation (NT2
    Neuron)
    NT2RI Culture cell NT2 cells treated by growth inhibitor for 2 weeks after
    RA induction for 5 weeks
    NT2RP Culture cell NT2 cells treated by RA for 5 weeks
    NTONG Tissue Tongue
    OCBBF Tissue Brain, Fetal
    PANCR Tissue Pancreas (CLONTECH #64031-1)
    PEBLM Primary culture cell Human peripheral blood mononuclear cells HPBMC5939
    (Takara Shuzo #CC2702)
    PERIC Tissue Pericardium (Invitrogen #D6105-01)
    PLACE Tissue Placenta
    PROST Tissue Prostate (CLONTECH #64038-1)
    PUAEN Primary culture cell Human pulmonary artery endothelial cells (Toyobo
    #T302K-05)
    RECTM Tissue Rectum (Invitrogen #D6110-01)
    SALGL Tissue Salivary Gland (CLONTECH #64026-1)
    SKMUS Tissue Skeletal Muscle (CLONTECH #64033-1)
    SKNMC Culture cell SK-N-MC cells (ATCC #HTB-10)
    SKNSH Culture cell SK-N-SH cells (RCB #RCB0426)
    SMINT Tissue Small Intestine (CLONTECH #64039-1)
    SPLEN Tissue Spleen (CLONTECH #64034-1)
    STOMA Tissue Stomach (CLONTECH #64090-1)
    SYNOV Tissue Synovial membrane tissue from rheumatioid arthritis
    TBAES Tissue Breast, Tumor (CLONTECH #64015-1)
    TCOLN Tissue Colon, Tumor (CLONTECH #64014-1)
    TESOP Tissue Esophageal, Tumor (Invitrogen #D6860-01)
    TESTI Tissue Testis (CLONTECH #64027-1)
    THYMU Tissue Thymus (CLONTECH #64028-1)
    TKIDN Tissue Kidney, Tumor (Invitrogen #D6870-01)
    TOVAR Tissue Ovary, Tumor (CLONTECH #64011-1)
    TRACH Tissue Trachea (CLONTECH #64091-1)
    TSTOM Tissue Stomach, Tumor (Invitrogen #D6920-01)
    TUTER Tissue Uterus, Tumor (CLONTECH #64008-1)
    UMVEN Primary culture cell Human umbilical vein endothelial cells HUVEC (Toyobo
    #T200K-05)
    UTERU Tissue Uterus (CLONTECH #64029-1)
  • The cDNA library with the high fullness ratio (the fullness ratio of 5′-end, which was calculated for each cDNA library by using the protein coding region found in known mRNA species as an index, was 90% in average) prepared by the improved oligo-capping method was constructed by using a eukaryotic expression vector pME18SFL3. The vector contains SR α promoter and SV40 small t intron in the upstream of the cloning site, and SV40 polyA added signal sequence site in the downstream. As the cloning site of pME18SFL3 has asymmetrical DraIII sites, and the ends of cDNA fragments contain SfiI sites complementary to the DraIII sites, the cloned cDNA fragments can be inserted into the downstream of the SR α promoter unidirectionally. Therefore, clones containing full-length cDNA can be expressed transiently by introducing the obtained plasmid directly into COS cells, etc. Thus, the clones can be analyzed very easily in terms of the proteins that are the gene products of the clones, or in terms of the biological activities of the proteins.
  • (3) Assessment of the 5′-end Completeness of Clones Derived from the cDNA Library Prepared by Oligo-Capping
  • With respect to the plasmid DNAs of clones derived from the libraries, the nucleotide sequences of cDNA 5′-ends (3′-ends as well in some cases) were determined in a DNA sequencer (ABI PRISM 3700, PE Biosystems), after sequencing reaction was conducted by using a DNA sequencing reagent (BigDye Terminator Cycle Sequencing FS Ready Reaction Kit, PE Biosystems) according to the manual. A database was constructed based on the obtained data.
  • The 5′-end completeness of about 1110,000 clones derived from the human cDNA libraries prepared by the improved oligo-capping method was determined by the following method. The clones whose 5′-end sequences were consistent with those of known human mRNA in the public database were judged to be “full-length” if they had a longer 5′-end sequence than that of the known human mRNA; or even though the 5′-end sequence was shorter, if it contained the translation initiation codon it was judged to have the “full-length” sequence. Clones which did not contain the translation initiation codon were judged to be “not-full-length”. The fullness ratio ((the number of full-length clones)/(the number of full-length and not-full-length clones)) at the 5′-end of the cDNA clones was determined by comparing with known human mRNA. As a result, the fullness ratio of the 5′-ends was 90%. The result indicates that the fullness ratio at the 5′-end sequence was extremely high in the human cDNA clones obtained by the oligo-capping method.
    • EXAMPLE 2 Sequencing Analysis of cDNA Ends and Selection of Full-Length Clones
  • With respect to the plasmid DNAs of clones obtained from each cDNA library, the 5′-end nucleotide sequences of the cDNAs were determined in a DNA sequencer (ABI PRISM 3700, PE Biosystems), after sequencing reaction was conducted by using a DNA sequencing reagent (Dye Terminator Cycle Sequencing FS Ready Reaction Kit, dRhodamine Terminator Cycle Sequencing FS Ready Reaction Kit or BigDye Terminator Cycle Sequencing FS Ready Reaction Kit, PE Biosystems) according to the manual. A database was constructed using the data obtained.
  • For the analyzed 5′-end sequences of cDNA clones, the data with the annotation of “complete cds” in the GenBank and UniGene were searched by BLAST homology search. When identical to certain human mRNA sequences, such cDNA clones were excluded. Then, clustering was carried out. When the identity was 90% or higher, and the length of consensus sequence was 50 base pairs or longer, the cDNA clones were assumed to belong to an identical cluster, and thus clustered. cDNA clones longer in the 5′ direction were selected from the members belonging to a cluster; if required, the 3′-end sequences of the selected clones were determined by the same analysis method as used to determine the 5′-end sequences. The data of the end sequences obtained were analyzed, and then the clones forming a sequence contig at 5′- and 3′-ends were excluded. Further, as mentioned above, the data was analyzed again by BLAST homology search; when identical to certain human mRNA sequences (including sequences patented and applied for), the cDNA clones were excluded. Thus, the cDNAs clones to be analyzed for their nucleotide sequence were obtained.
    • EXAMPLE 3 Analysis of the Full-Length Nucleotide Sequences
  • The full-length nucleotide sequences of the selected clones were determined. The nucleotide sequence determination was mainly performed by primer walking method comprising the dideoxy terminator method using custom-made synthetic DNA primers. Namely, the nucleotide sequences of the DNAs were determined in a sequencer from PE Biosystems, after sequencing reaction was carried out with a DNA sequencing reagent from the same supplier using the custom-made synthetic DNA primers according to the manual. A part of the clones were analyzed with a DNA sequencer from Licor.
  • Further, the nucleotide sequences of a part of the clones were determined by the shotgun method where the plasmids containing the cDNAs were digested at random were used, instead of the use of custom-made primers, by the same method in the DNA sequencer. The full-length nucleotide sequences were finally determined by completely assembling the partial nucleotide sequences obtained by the above method.
  • Then, the regions translatable to proteins were deduced from the determined full-length nucleotide sequences, and thereby the amino acid sequences were determined. SEQ ID NOs corresponding to the respective sequences are shown in Table 1.
    • EXAMPLE 4 Functional Prediction by Homology Search
  • For the determined nucleotide sequences, GenBank, SwissProt, UniGene, and nr were searched by BLAST. The clones exhibiting higher homology, which were convenient to predict their functions based on the nucleotide sequences and deduced amino acid sequences, were selected based on the BLAST search hit data whose P value or E value was 10−4 or lower and for which the length of consensus sequence×homology=30 or higher in the amino acid database search. Further, from them, representative clones were selected, which are shown as Homology Search Result Data in the last part herein. Accordingly, the data shown herein are merely the representative data, and the molecule exhibiting homology to each clone is not limited thereto. Further, with respect to a part of clones, the BLAST search hit data that did not meet the criteria as described above are not shown herein.
    • EXAMPLE 5 Search for Signal Sequence, Transmembrane Domain and Other Functional Domains in the Deduced Amino Acid Sequences
  • With respect to the amino acid sequences deduced from the full-length nucleotide sequences, the prediction was made for the presence of signal sequence at the amino terminus, the presence of transmembrane domain, and the presence of functional protein domains (motifs). The signal sequence at the amino terminus was searched for by PSORT [K. Nakai & M. Kanehisa, Genomics, 14: 897-911 (1992)]; the transmembrane domain, by SOSUI [T. Hirokawa et al., Bioinformatics, 14: 378-379 (1998)] (Mitsui Knowledge Industry); the function domain, by Pfam (http://www.sanger.ac.uk/Software/Pfam/index.shtml). The amino acid sequence in which the signal sequence at the amino terminus or transmembrane domain had been predicted to be present by PSORT or SOSUI were assumed to be a secretory or membrane protein. Further, when the amino acid sequence hit a certain functional domain by the Pfam functional domain search, the protein function can be predicted based on the hit data, for example, by referring to the function categories on the PROSITE (http://www.expasy.ch/cgi-bin/prosite-list.pl). In addition, the functional domain search can also be carried out on the PROSITE.
  • The search results obtained with the respective programs are shown below.
  • The clones whose deduced amino acid sequences were detected to have the signal sequences by PSORT are as follows.
  • ADRGL20013520, ASTRO20005330, ASTRO20055750, BNGH420088500, BRACE20038000, BRACE20081720, BRACE20101710, BRACE20224480, BRACE20257100, BRACE20273890, BRALZ20013500, BRALZ20054710, BRALZ20077930, BRAMY20063970, BRAMY20284910, BRAWH20016860, BRAWH20064050, BRCOC10000870, BRCOC20078640, BRCOC20090520, BRCOC20101230, BRCOC20114180, BRCOC20121720, BRCOC20134480, BRCOC20136750, BRHIP20179200, BRHIP20198190, BRHIP20217620, BRSSN20003120, BRSSN20137020, COLON10001350, COLON20093370, CTONG20158660, CTONG20267700, D3OST20036070, D3OST20038560, D6OST20005070, FCBBF10001210, FCBBF10002430, FCBBF10003760, FCBBF10005740, FCBBF20042560, FCBBF30086440, FCBBF30095260, FCBBF30172550, FCBBF30238870, FEBRA20009090, FEBRA20029860, FEBRA20086620, FEBRA20092890, FEBRA20111460, FEBRA20130190, FEBRA20145780, FEBRA20235500, HCHON20064590, HCHON20067700, HCHON20086720, HEART20049410, HHDPC20001040, HHDPC20014320, KIDNE20011400, KIDNE20022620, KIDNE20126130, KIDNE20127450, LIVER20064690, MESAN10001260, MESAN20038510, MESAN20115970, MESAN20152770, MESAN20153910, NT2NE20118960, NT2NE20124480, NT2NE20183760, NT2RI20003480, NT2RI20023910, NT2RI20028470, NT2RI20040930, NT2RP70134990, NTONG20029700, NTONG20063010, OCBBF20019830, OCBBF20078920, OCBBF20086400, OCBBF20087010, OCBBF20116850, OCBBF20122620, OCBBF20130910, OCBBF20188730, PEBLM20075980, PLACE60086400, PROST20175290, SKNSH20028660, SMINT20009840, SMINT20022020, SMINT20073650, SMINT20095050, SMINT20105330, SMINT20127930, SMINT20153260, SMINT20157450, SMINT20173240, SMINT20178550, SMINT20191420, SMINT20192000, SPLEN20079510, SPLEN20095810, SPLEN20118300, SPLEN20141360, SPLEN20157880, SPLEN20171890, SPLEN20213830, STOMA20005390, STOMA20056640, STOMA20080500, STOMA20088380, SYNOV20001520, SYNOV20001730, SYNOV20002790, SYNOV20002970, SYNOV20004260, SYNOV20007000, SYNOV20008240, SYNOV20009230, SYNOV20010880, SYNOV20011110, SYNOV20013000, TESOP20005690, TESTI20123560, TESTI20208400, TESTI20211220, TESTI20272960, TESTI20309170, TESTI20316870, TESTI20385960, TESTI20390260, TESTI20391770, TESTI20396130, TESTI20415170, TESTI20421490, TESTI20441940, TESTI20444180, TESTI20463580, THYMU10005360, THYMU20027560, THYMU20032870, THYMU20039810, THYMU20066100, THYMU20106710, THYMU20111830, THYMU20161640, THYMU20162190, THYMU20194420, THYMU20222890, THYMU20241850, TKIDN20005210, TRACH20029540, TRACH20034840, TRACH20050040, TRACH20069180, TRACH20085400, TRACH20136710, TRACH20145440, TRACH20180840, UTERU20158300, UTERU20158800, UTERU20161570
  • The clones whose deduced amino acid sequences were detected to have the transmembrane domains by SOSUI are as follows. Numerals indicate the numbers of transmembrane domains detected in the deduced amino acid sequences. Of the search result, the clone name and the number of transmembrane domains are demarcated by a double slash mark (//).
  • ADIPS10000640//3, ADRGL20018540//1, ADRGL20035850//2, ASTRO20001410//1, ASTRO20005330//3, ASTRO20058630//4, ASTRO20190390//1, BEAST20004540//1, BGGI110000240//2, BRACE20006400//1, BRACE20038470//1, BRACE20039040//1, BRACE20039540//1, BRACE20051380//1, BRACE20059370//1, BRACE20061050//1, BRACE20063630//2, BRACE20067430//1, BRACE20069090//2, BRACE20101700//2,
  • BRACE20116110//2, BRACE20147800//1, BRACE20153680//5, BRACE20163350//1, BRACE20179340//6, BRACE20188470//4, BRACE20195100//1, BRACE20201570//1, BRACE20210140//1, BRACE20224480//1, BRACE20224500//1, BRACE20228480//1, BRACE20232840//1, BRACE20238000//2, BRACE20274080//1, BRALZ20013500//2, BRALZ20064740//1, BRALZ20069760//3, BRALZ20073760//3, BRAMY20000860//2,
  • BRAMY20002770//2, BRAMY20025840//1, BRAMY20039260//3, BRAMY20060920//1, BRAMY20063970//3, BRAMY20111960//1, BRAMY20112800//2, BRAMY20134140//2, BRAMY20135900//1, BRAMY20136210//1, BRAMY20144620//3, BRAMY20152110//1, BRAMY20174550//4, BRAMY20181220//2, BRAMY20195090//1, BRAMY20211390//1, BRAMY20211420//10, BRAMY20215230//1, BRAMY20218250//10, BRAMY20218670//3,
  • BRAMY20229800//1, BRAMY20231720//1, BRAMY20247280//1, BRAMY20252180//2, BRAMY20273960//1, BRAMY20277170//5, BRAWH20015350//1, BRAWH20015890//2, BRAWH20016860//3, BRAWH20018730//10, BRAWH20030250//4, BRAWH20110790//3, BRAWH20121640//11, BRAWH20122580//2, BRAWH20132190//2, BRCAN20064010//2, BRCAN20071190//1, BRCAN20091560//1, BRCAN20103740//1, BRCAN20224720//1,
  • BRCAN20273550//5, BRCAN20280360//6, BRCAN20285450//2, BRCOC20004040//4, BRCOC20006370//2, BRCOC20041750//1, BRCOC20077690//2, BRCOC20090520//1, BRCOC20091960//2, BRCOC20101230//6, BRCOC20107300//1, BRCOC20114180//3, BRCOC20121720//7, BRCOC20134480//3, BRCOC20136750//2, BRHIP20000870//2, BRHIP20003120//3, BRHIP20111200//1, BRHIP20118380//1, BRHIP20118910//2,
  • BRHIP20121410//3, BRHIP20135100//1, BRHIP20183690//9, BRHIP20191490//2, BRHIP20191770//1, BRHIP20207430//1, BRHIP20208270//1, BRHIP20208590//2, BRHIP20217620//1, BRHIP20233090//1, BRHIP20234380//1, BRHIP20238880//1, BRHIP20283030//1, BRSSN20003120//7, BRSSN20043040//2, BRSSN20066110//2, BRSSN20137020//2, BRSSN20142940//1, BRSSN20146100//3, BRSSN20151990//2,
  • BRSSN20169050//2, BRSTN20002200//1, BRTHA20046290//2, BRTHA20046420//5, CTONG10000100//6, CTONG10000940//1, CTONG10001650//1, CTONG20004690//5, CTONG20092570//7, CTONG20092580//2, CTONG20095340//5, CTONG20099380//2, CTONG20103480//1, CTONG20105080//9, CTONG20114290//2, CTONG20114740//3, CTONG20119200//2, CTONG20120770//1, CTONG20124220//3, CTONG20124730//1,
  • CTONG20131490//1, CTONG20132220//1, CTONG20133480//2, CTONG20139340//2, CTONG20149950//1, CTONG20155400//1, CTONG20158660//9, CTONG20161850//2, CTONG20267700//1, D3OST10001090//5, D3OST20036070//1, D3OST20038560//1, D3OST30002580//2, D9OST20002780//2, D9OST20015470//2, D9OST20026730//1, D9OST20040180//7, DFNES20025880//1, FCBBF10000240//8, FCBBF10000380//1,
  • FCBBF10001150//1, FCBBF10001210//2, FCBBF10001550//1, FCBBF10002700//2, FCBBF10003220//1, FCBBF10005460//1, FCBBF20032970//1, FCBBF20042560//3, FCBBF20051220//2, FCBBF30008470//2, FCBBF30012350//1, FCBBF30024750//1, FCBBF30078290//1, FCBBF30086440//3, FCBBF30090690//1, FCBBF30095260//2, FCBBF30123470//3, FCBBF30172550//1, FCBBF30175310//9, FCBBF30190850//1,
  • FCBBF30215060//4, FCBBF30238870//1, FCBBF30251420//1, FCBBF30279030//5, FEBRA20002100//5, FEBRA20037260//1, FEBRA20080810//5, FEBRA20093520//1, FEBRA20095880//1, FEBRA20111460//1, FEBRA20125070//1, FEBRA20130190//1, FEBRA20140100//3, FEBRA20145780//2, FEBRA20211710//1, FEBRA20229630//3, FEBRA20235500//10, HCHON20000380//2, HCHON20007510//1, HCHON20008180//1,
  • HCHON20016650//7, HCHON20035130//1, HCHON20040020//1, HCHON20067700//1, HCHON20068710//4, HEART20003060//1, HEART20005410//1, HEART20034320//2, HEART20049800//1, HEART20072310//2, HHDPC10000830//3, HHDPC20001040//1, HHDPC20014320//1, HHDPC20034720//1, HHDPC20068620//1, HHDPC20084140//1, HHDPC20091780//2, HLUNG10000550//2, KIDNE20003940//10, KIDNE20007770//2,
  • KIDNE20021910//4, KIDNE20022620//1, KIDNE20100070//2, KIDNE20101510//2, KIDNE20109730//2, KIDNE20121880//5, KIDNE20125630//2, KIDNE20126010//1, KIDNE20130450//2, KIDNE20131580//7, KIDNE20137340//4, KIDNE20181660//1, LIVER20035110//1, LIVER20045650//1, LIVER20062510//1, LIVER20075680//1, LIVER20087060//1, LIVER20091180//1, MESAN20014500//6, MESAN20027090//2,
  • MESAN20038510//1, MESAN20089360//1, MESAN20103120//5, MESAN20115970//4, MESAN20139360//1, MESAN20153910//1, NOVAR20000380//1, NT2NE20010050//1, NT2NE20021620//1, NT2NE20118960//4, NT2NE20131890//1, NT2NE20132170//9, NT2NE20155110//1, NT2NE20156260//1, NT2NE20159740//3, NT2NE20177520//2, NT2RI20023910//2, NT2RI20025400//2, NT2RI20054050//8, NT2RI20076290//8,
  • NT2RI20086220//4, NT2RI20091940//3, NT2RI20244600//6, NT2RP70072690//1, NT2RP70081610//6, NT2RP70122910//2, NT2RP70125160//3, NT2RP70133740//4, NT2RP70137290//1, NT2RP70179710//1, NT2RP70188020//1, NTONG20028070//1, NTONG20048060//1, NTONG20049910//1, NTONG20051530//1, NTONG20061870//1, NTONG20067830//1, NTONG20092330//2, OCBBF10001750//2, OCBBF20013890//3,
  • OCBBF20023570//1, OCBBF20026630//1, OCBBF20037440//1, OCBBF20050770//1, OCBBF20059560//2, OCBBF20063320//1, OCBBF20072320//1, OCBBF20080050//2, OCBBF20086400//1, OCBBF20086910//1, OCBBF20088140//1, OCBBF20091150//1, OCBBF20107090//2, OCBBF20116850//2, OCBBF20120390//12, OCBBF20130910//2, OCBBF20132850//3, OCBBF20155060//2, OCBBF20178880//1, OCBBF20180120//10,
  • OCBBF20180840//1, PANCR10000910//3, PEBLM20024320//2, PEBLM20040150//2, PEBLM20074370//1, PERIC20004220//4, PLACE60121080//1, PLACE60161600//2, PLACE60177140//6, PROST20005050//1, PROST20050670//1, PROST20107820//4, PROST20116600//2, PROST20120160//1, PROST20127800//3, PROST20146010//3, PROST20164440//3, PROST20169800//1, PROST20170980//1, PROST20191640//1,
  • PUAEN20003740//2, PUAEN20030180//2, SALGL10001710//5, SKMUS20007800//7, SKMUS20011640//3, SKMUS20020840//3, SKMUS20028210//1, SKMUS20028400//1, SKMUS20077400//1, SKNSH20031740//1, SKNSH20051940//1, SKNSH20063040//3, SMINT20011990//1, SMINT20022020//4, SMINT20029760//1, SMINT20040860//7, SMINT20049090//1, SMINT20053870//1, SMINT20095050//2, SMINT20100680//1,
  • SMINT20105330//1, SMINT20144890//1, SMINT20157450//5, SMINT20173240//3, SMINT20178550//3, SMINT20192000//1, SPLEN20003070//2, SPLEN20008740//4, SPLEN20026950//1, SPLEN20029310//3, SPLEN20095810//1, SPLEN20097330//1, SPLEN20118300//9, SPLEN20141360//1, SPLEN20141990//1, SPLEN20144520//3, SPLEN20152760//2, SPLEN20157880//1, SPLEN20165310//1, SPLEN20167200//1,
  • SPLEN20169220//2, SPLEN20169720//1, SPLEN20171890//4, SPLEN20172120//2, SPLEN20186430//6, SPLEN20211570//2, SPLEN20211940//3, SPLEN20213830//2, SPLEN20273950//1, SPLEN20292950//7, SPLEN20293800//4, SPLEN20304950//2, SPLEN20329240//1, STOMA20006780//2, STOMA20008880//1, STOMA20051200//1, STOMA20056670//1, STOMA20062130//1, STOMA20077450//2, STOMA20080500//4,
  • SYNOV20013560//1, SYNOV30001840//4, TBAES20003150//2, TESOP20005690//3, TESTI20001720//3, TESTI20036380//6, TESTI20037560//1, TESTI20082330//1, TESTI20094120//8, TESTI20110280//1, TESTI20123080//1, TESTI20123560//3, TESTI20128350//1, TESTI20136100//2, TESTI20136710//2, TESTI20143390//8, TESTI20148000//1, TESTI20164100//3, TESTI20193360//1, TESTI20209810//1,
  • TESTI20209990//1, TESTI20214250//2, TESTI20230250//1, TESTI20231940//1, TESTI20237520//2, TESTI20242990//2, TESTI20254220//7, TESTI20254860//1, TESTI20265970//2, TESTI20271850//2, TESTI20272960//8, TESTI20284880//2, TESTI20291310//4, TESTI20291960//5, TESTI20303360//1, TESTI20303420//1, TESTI20307700//2, TESTI20316870//1, TESTI20333000//2, TESTI20347180//6,
  • TESTI20347300//1, TESTI20355020//1, TESTI20357960//1, TESTI20370810//9, TESTI20373820//1, TESTI20383880//1, TESTI20390410//1, TESTI20391770//3, TESTI20393530//1, TESTI20397760//2, TESTI20401280//1, TESTI20422640//2, TESTI20441940//5, TESTI20444130//1, TESTI20449200//6, TESTI20463520//1, TESTI20463580//1, THYMU20027560//4,
  • THYMU20032870//1, THYMU20039810//3, THYMU20100410//2, THYMU20106710//1, THYMU20111830//1, THYMU20141670//1, THYMU20147770//1, THYMU20159430//1, THYMU20161640//4, THYMU20162190//2, THYMU20173980//2, THYMU20208300//1, THYMU20216840//2, THYMU20229220//1, THYMU20241850//2, THYMU20277390//7, TRACH20002870//3, TRACH20003590//1, TRACH20016210//1, TRACH20029540//1, TRACH20033230//6, TRACH20042920//6,
  • TRACH20050040//2, TRACH20068660//6, TRACH20076740//4, TRACH20085400//2, TRACH20085830//1, TRACH20109650//2, TRACH20111130//1, TRACH20128110//5, TRACH20134950//1, TRACH20140820//1, TRACH20145440//1, TRACH20168350//1, UMVEN20000690//1, UTERU20030570//5, UTERU20040610//1, UTERU20055480//2, UTERU20076390//4, UTERU20094350//1, UTERU20135860//2, UTERU20158300//3,
  • UTERU20158800//2, UTERU20161570//6, UTERU20178100//1, UTERU20186740//1
  • The Names of clones whose deduced amino acid sequences were detected to have functional domains with Pfam, and the name of hit functional domains are as follows. The search result is indicated as “clone name//functional domain name”. When the clone has multiple hit functional domains, they are listed and demarcated by a double slash mark (//). When the clone has multiple hits of an identical functional domain, each is listed without abridgment.
  • 3NB6910001910//tRNA synthetases class II (A)// tRNA synthetases class II (A)// DHHA1 domain
  • 3NB6920014590//Homeobox domain
  • ADIPS20004250//Zinc finger, C2H2 type// DNA binding domain with preference for// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type// UvrD/REP helicase// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • ADRGL10001470//Cytochrome P450//Cytochrome P450
  • ADRGL20011190//Calponin homology (CH) domain// Calponin homology (CH) domain// Pou domain-N-terminal to homeobox domain
  • ADRGL20018300//TPR Domain// TPR Domain// TPR Domain// TPR Domain// PPR repeat// TPR Domain
  • ADRGL20035850//Cytochrome P450
  • ADRGL20048330//PHD-finger// Rabphilin-3A effector domain// C2 domain// C2 domain
  • ASTRO20008010//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • ASTRO20012490//Eukaryotic initiation factor 1A
  • ASTRO20027430//Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat
  • ASTRO20033160//Mitochondrial carrier proteins// Mitochondrial carrier proteins// Mitochondrial carrier proteins
  • ASTRO20055750//Collagen triple helix repeat (20 copies)// Heavy-metal-associated domain
  • ASTRO20058630//Vacuolar sorting protein 9 (VPS9) domain
  • ASTRO20064750//Zinc finger, C2H2 type// Nuclear transition protein 2
  • ASTRO20072210//PDZ domain (Also known as DHR or GLGF).
  • ASTRO20084250//KH domain// Zinc finger, C3HC4 type (RING finger)
  • ASTRO20105820//FAD binding domain
  • ASTRO20106150//Calpain family cysteine protease// Calpain large subunit, domain III
  • ASTRO20108190//Rap/ran-GAP
  • ASTRO20125520//DnaJ domain
  • ASTRO20130500//ThiF family// Repeat in ubiquitin-activating (UBA) pro
  • ASTRO20143630//KH domain// Bacterial regulatory proteins, crp family
  • ASTRO20155290//TPR Domain// TPR Domain// TPR Domain
  • ASTRO20168470//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BGGI110001930//UBX domain
  • BGGI120006160//Fumarylacetoacetate (FAA) hydrolase fam
  • BLADE20003400//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BLADE20003890//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Src homology domain 2//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Src homology domain 2//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BNGH420088500//SAM domain (Sterile alpha motif)
  • BRACE20003070//SAM domain (Sterile alpha motif)
  • BRACE20011070//F-box domain.
  • BRACE20027620//Dienelactone hydrolase family// Dienelactone hydrolase family
  • BRACE20038000//ATP synthase, Delta/Epsilon chain// Dual specificity phosphatase, catalytic d
  • BRACE20039540//Immunoglobulin domain// Adenovirus E3 region protein CR2
  • BRACE20050900//TPR Domain// TPR Domain// TPR Domain// TPR Domain
  • BRACE20052160//SAM domain (Sterile alpha motif)
  • BRACE20053280//PDZ domain (Also known as DHR or GLGF).
  • BRACE20053480//Ribosomal protein L22p/L17e// Glycosyl hydrolases family 38
  • BRACE20053630//Plant thionins// Mitochondrial carrier proteins// Mitochondrial carrier proteins
  • BRACE20057620//Eukaryotic initiation factor 4E
  • BRACE20058580//L1 (late) protein
  • BRACE20059370//FERM domain (Band 4.1 family)
  • BRACE20060550//Ank repeat// Ank repeat// Ank repeat// PEP-utilizing enzymes
  • BRACE20060720//WD domain, G-beta repeat// WD domain, G-beta repeat
  • BRACE20060890//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BRACE20062640//Alanine racemase// RNB-like proteins
  • BRACE20063780//NOL1/NOP2/sun family
  • BRACE20064880//KH domain// KH domain// KH domain
  • BRACE20068590//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BRACE20096200//Sir2 family// Sir2 family
  • BRACE20107530//short chain dehydrogenase
  • BRACE20115920//Spectrin repeat// Fes/CIP4 homology domain// Interleukin 10
  • BRACE20148240//Ras family
  • BRACE20151320//Zinc finger, C3HC4 type (RING finger)
  • BRACE20153680//Sir2 family// Ion transport protein
  • BRACE20163350//Immunoglobulin domain// Immunoglobulin domain
  • BRACE20177200//RanBP1 domain.
  • BRACE20188470//ABC transporter// Thymidylate kinase
  • BRACE20190040//Integrase DNA binding domain
  • BRACE20192440//Translation initiation factor IF-3
  • BRACE20223330//3′-5′ exonuclease// Adenylylsulfate kinase// Protein of unknown function DUF82.
  • BRACE20232840//4Fe-4S binding domain// ABC transporter// ABC transporter// ATPases associated with various cellular act
  • BRACE20240740//Ribosomal protein L36
  • BRACE20253330//PDZ domain (Also known as DHR or GLGF).
  • BRACE20269200//Heat-labile enterotoxin alpha chain
  • BRACE20273890//UBA domain
  • BRACE20284100//Polysaccharide lyase family 8
  • BRACE20286360//Alpha adaptin carboxyl-terminal domain
  • BRALZ20013500//Keratin, high sulfur B2 protein// u-PAR/Ly-6 domain
  • BRALZ20054710//Zinc finger, C3HC4 type (RING finger)// TRAF-type zinc finger
  • BRALZ20058880//STAT protein
  • BRALZ20077930//Ribosomal protein S27a
  • BRAMY20000520//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
  • BRAMY20002770//DB module
  • BRAMY20025840//Sec7 domain
  • BRAMY20045240//Flagellar L-ring protein
  • BRAMY20054880//Pou domain-N-terminal to homeobox domain
  • BRAMY20103570//DNA binding domain with preference for A/T r
  • BRAMY20104640//Eukaryotic protein kinase domain// Protein kinase C terminal domain
  • BRAMY20111960//Ribosomal protein L36
  • BRAMY20121620//TPR Domain// TPR Domain// TPR Domain// TPR Domain// PPR repeat
  • BRAMY20124260//ZU5 domain// Death domain
  • BRAMY20148130//WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// TBC domain
  • BRAMY20153110//ACT domain// Biopterin-dependent aromatic amino acid hydroxylase
  • BRAMY20157820//Kinesin motor domain
  • BRAMY20162510//MAGE family
  • BRAMY20167060//Collagen triple helix repeat (20 copies)
  • BRAMY20174550//ABC transporter transmembrane region.// Phosphoribulokinase// Adenylylsulfate kinase// FtsK/SpoIIIE family// ABC transporter
  • BRAMY20211390//Zinc finger, C3HC4 type (RING finger)
  • BRAMY20211420//Transient receptor// GGL domain
  • BRAMY20213100//LIM domain containing proteins// GATA zinc finger// ‘Paired box’ domain
  • BRAMY20215230//ribonuclease.
  • BRAMY20217460//EF hand// EF hand// EF hand
  • BRAMY20218250//Ion transport protein// Sir2 family// Ion transport protein
  • BRAMY20240040//Nuclear transition protein 2
  • BRAMY20245300//Fanconi anaemia group C protein// Metallo-beta-lactamase superfamily
  • BRAMY20248490//Sodium:sulfate symporter transmembrane
  • BRAMY20260910//Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BRAMY20270730//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C3HC4 type (RING finger)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BRAMY20271400//Phorbol esters/diacylglycerol binding dom// PHD-finger
  • BRAMY20277170//K+ channel tetramerisation domain// NADH-ubiquinone/plastoquinone oxidoreduc// Ion transport protein// Transmembrane region cyclic Nucleotide G
  • BRAMY20285160//NTR/C345C module
  • BRAWH20002320//Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat
  • BRAWH20011710//Ank repeat// Ank repeat// Ank repeat// CAP-Gly domain// CAP-Gly domain
  • BRAWH20012390//EF hand// EF hand// EF hand
  • BRAWH20016620//Eukaryotic protein kinase domain// EIAV coat protein, gp90
  • BRAWH20018730//Sugar (and other) transporter
  • BRAWH20028110//4Fe-4S binding domain// LIM domain containing proteins// LIM domain containing proteins// LIM domain containing proteins// LIM domain containing proteins// Villin headpiece domain
  • BRAWH20030250//jmjN domain
  • BRAWH20064050//Sushi domain (SCR repeat)// EGF-like domain// Trypsin Inhibitor like cysteine rich domain// EGF-like domain// Granulins// Granulins// EGF-like domain
  • BRAWH20075700//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BRAWH20096780//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BRAWH20101360//Hexokinase
  • BRAWH20103290//CRAL/TR10 domain.// Spectrin repeat// Extracellular link domain// RhoGEF domain// PH domain
  • BRAWH20110960//PCI domain
  • BRAWH20112940//Similarity to lectin domain of ricin beta-chain, 3 copies.
  • BRAWH20114000//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
  • BRAWH20117950//Carboxylesterases
  • BRAWH20118230//Transforming growth factor beta like domain
  • BRAWH20121640//eubacterial secY protein// Transmembrane amino acid transporter protein
  • BRAWH20132190//Acetyltransferase (GNAT) family
  • BRAWH20137480//Villin headpiece domain
  • BRAWH20138660//Adaptor complexes medium subunit family
  • BRAWH20149340//IQ calmodulin-binding motif// RhoGEF domain
  • BRAWH20164460//Sigma-54 interaction domain// ATPases associated with various cellular activities (AAA)
  • BRAWH20171030//Adenylate kinase// NB-ARC domain// ATPases associated with various cellu
  • BRAWH20185060//Integrase core domain
  • BRCAN10001490//‘chromo’ (CHRromatin Organization MOdifier)
  • BRCAN20003460//Thioredoxin
  • BRCAN20071190//Ubiquitin family// UBX domain
  • BRCAN20091560//Rieske [2Fe-2S] domain// Phosphoglucose isomerase// FAD binding domain// Pyridine nucleotide-disulphide oxidoreductase// Phytoene dehydrogenase related enzyme
  • BRCAN20124080//WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat
  • BRCAN20273550//FATC domain
  • BRCAN20273640//Formin Homology 2 Domain
  • BRCAN20280210//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BRCAN20280360//PAP2 superfamily
  • BRCOC20001860//FliP family// Glycosyl hydrolase family 47
  • BRCOC20004040//7 transmembrane receptor (rhodopsin family)// Neurohypophysial hormones, C-terminal Domain
  • BRCOC20006370//Plexin repeat
  • BRCOC20008160//Spectrin repeat// Spectrin repeat// Tropomyosins// Spectrin repeat// Adenylate cyclase// Spectrin repeat// FF domain// Spectrin repeat// Spectrin repeat// Spectrin repeat
  • BRCOC20008500//Vacuolar sorting protein 9 (VPS9) domain// Ras association (RalGDS/AF-6) domain
  • BRCOC20023230//Reverse transcriptase (RNA-dependent DNA polymerase)
  • BRCOC20026640//Gag P30 core shell protein
  • BRCOC20027510//Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat
  • BRCOC20031250//Triosephosphate isomerase
  • BRCOC20035130//14-3-3 proteins
  • BRCOC20037320//Apolipoprotein A1/A4/E family
  • BRCOC20055420//Helix-loop-helix DNA-binding domain// Myristoyl-CoA
  • BRCOC20074760//Herpesvirus UL25 family// Beige/BEACH domain
  • BRCOC20110100//Integrase core domain
  • BRCOC20121720//PHD-finger
  • BRCOC20144000//Helicases conserved C-terminal domain
  • BRCOC20178270//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BRCOC20178560//LIM domain containing proteins// LIM domain containing proteins// LIM domain containing proteins// Ribosomal protein L24e// LIM domain containing proteins
  • BRHIP10001290//Ribosomal protein S3, C-terminal domai// Similarity to lectin domain of ricin b
  • BRHIP20001630//Protein of unknown function DUF16
  • BRHIP20003120//Dehydrins// Reticulon
  • BRHIP20005530//ThiF family
  • BRHIP20096850//ICE-like protease (caspase) p20 domain// Aminotransferases class-I
  • BRHIP20115080//PH domain
  • BRHIP20118910//Fibronectin type I domain
  • BRHIP20119330//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BRHIP20132860//PDZ domain (Also known as DHR or GLGF).
  • BRHIP20143730//MYND finger
  • BRHIP20153600//RNA recognition motif. (a.k.a. RRM, RBD, or
  • BRHIP20174040//GAF domain// GAF domain// Transposase, Mutator family//3′5′-cyclic nucleotide phosphodiesterase
  • BRHIP20176420//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
  • BRHIP20183690//DEAD/DEAH box helicase// Integral membrane protein DUF6// Integral membrane protein DUF7
  • BRHIP20189980//bZIP transcription factor
  • BRHIP20191860//Helix-loop-helix DNA-binding domain
  • BRHIP20207990//Phorbol esters/diacylglycerol binding dom// Zinc finger, C3HC4 type (RING finger)// PHD-finger
  • BRHIP20222280//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BRHIP20236950//Outer Capsid protein VP4 (Hemagglutinin)
  • BRHIP20238600//WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat
  • BRHIP20238880//wnt family of developmental signaling protei
  • BRHIP20249110//Hexokinase// Hexokinase
  • BRHIP20252450//Spectrin repeat// Spectrin repeat// Spectrin repeat// Phosphoenolpyruvate carboxykinase// Spectrin repeat// Spectrin repeat// Spectrin repeat// eRF1-like proteins// Spectrin repeat
  • BRHIP20253660//SH3 domain
  • BRHIP20283030//Cadherin domain// Cadherin domain// Cadherin domain// Cadherin domain// Cadherin domain// Cadherin domain// Cadherin domain// Cadherin domain
  • BRHIP20285830//Intermediate filament proteins
  • BRHIP30004570//Sushi domain (SCR repeat)// Sushi domain (SCR repeat)// Sushi domain (SCR repeat)// Sushi domain (SCR repeat)
  • BRHIP30004880//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Fibronectin type III domain// Fibronectin type III domain
  • BRSSN20003120//7 transmembrane receptor (metabotropic gluta
  • BRSSN20013420//Histone deacetylase family// Zn-finger in ubiquitin-hydrolases and o
  • BRSSN20014260//Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat
  • BRSSN20015790//Pyridoxal-dependent decarboxylase
  • BRSSN20021600//BTB/POZ domain// Kelch motif// Kelch motif// Kelch motif// Kelch motif// Kelch motif// Kelch motif
  • BRSSN20038200//Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif// Initiator RepB protein// RasGEF domain
  • BRSSN20039370//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • BRSSN20046790//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type
  • BRSSN20101100//‘Cold-shock’ DNA-binding domain
  • BRSSN20105870//ATPases associated with various cellular activities (AAA)
  • BRSSN20117990//short chain dehydrogenase
  • BRSSN20120810//Trypsin
  • BRSSN20146100//Adenylate and Guanylate cyclase catalytic domain// Adenylate and Guanylate cyclase catalytic domain// Zinc finger, C4 type (two domains)// Adenylate and Guanylate cyclase catalytic domain
  • BRSSN20176820//Wiskott Aldrich syndrome homology region 2
  • BRSSN20177570//Phosducin
  • BRSSN20187310//Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat
  • BRSTN10000830//Kelch motif// Kelch motif// Kelch motif// Kelch motif
  • BRSTN20005360//TPR Domain// TPR Domain
  • BRTHA20000570//Reverse transcriptase (RNA-dependent DNA pol
  • BRTHA20004740//Phosphoglycerate kinases// lactate/malate dehydrogenase// Flavoprotein// short chain dehydrogenase// Zinc-binding dehydrogenases
  • BRTHA20046290//Transmembrane 4 family CD34C30004240//RhoGAP domain
  • COLON10001350//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • CTONG10000220//Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat
  • CTONG10000620//Sec7 domain// PH domain// Josephin
  • CTONG10000930//Armadillo/beta-catenin-like repeats
  • CTONG10000940//Ank repeat// Ank repeat// Ank repeat
  • CTONG10002770//Calponin homology (CH) domain// Calponin homology (CH) domain
  • CTONG20009770//Proteasome/cyclosome repeat// Proteasome/cyclosome repeat// Proteasome/cyclosome repeat// Proteasome/cyclosome repeat// Proteasome/cyclosome repeat// Proteasome/cyclosome repeat//Proteasome/cyclosome repeat
  • CTONG20014280//WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat
  • CTONG20027090//Glypican// Leucine Rich Repeat// Leucine Rich Repeat
  • CTONG20050280//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • CTONG20075860//Ribulose bisphosphate carboxylase, smal
  • CTONG20076130//Hepatitis C virus non-structural protein NS2
  • CTONG20085950//SCAN domain// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • CTONG20092570//Integral membrane protein DUF6//Uncharacterized protein family UPF0005
  • CTONG20092700//BTB/POZ domain
  • CTONG20093950//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • CTONG20095340//E1-E2 ATPase
  • CTONG20096750//Disintegrin
  • CTONG20098440//Acyltransferase
  • CTONG20099550//GGL domain
  • CTONG20105080//Integral membrane protein DUF6
  • CTONG20106520//Pyridoxal-phosphate dependent enzyme
  • CTONG20114290//Apolipoprotein A1/A4/E family
  • CTONG20118150//WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat
  • CTONG20118250//Eukaryotic-type carbonic anhydrase
  • CTONG20121010//Zinc finger, C2H2 type// CONSTANS family zinc finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • CTONG20121580//Kinesin motor domain// FHA domain// Histidine carboxylase PI chain
  • CTONG20124010//WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat
  • CTONG20125640//Ribosomal protein L10//60s Acidic ribosomal protein
  • CTONG20128430//Beta/Gamma crystallin// Beta/Gamma crystallin// Beta/Gamma crystallin// Beta/Gamma crystallin// Beta/Gamma crystallin// Similarity to lectin domain of ricin b
  • CTONG20129960//F-box domain.// UvrD/REP helicase// UvrD/REP helicase// Viral (Superfamily 1) RNA helicase
  • CTONG20131560//PDZ domain (Also known as DHR or GLGF).
  • CTONG20133390//Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C3HC4 type (RING finger)// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • CTONG20133520//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • CTONG20139860//Ank repeat// Ank repeat// Ank repeat
  • CTONG20140580//Domain of unknown function DUF25//SNF2 and others N-terminal domain// SNF2 and others N-terminal domain// Small cytokines (intecrine/chemokine), inter
  • CTONG20143690//MYND finger
  • CTONG20146300//Reverse transcriptase (RNA-dependent DNA pol
  • CTONG20149460//BTB/POZ domain// Kelch motif// Kelch motif// Kelch motif// Domain of unknown function// Kelch motif// Kelch motif// Kelch motif
  • CTONG20153300//C. elegans Srg family integral membrane prote// TBC domain
  • CTONG20153580//F-box domain.// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat
  • CTONG20155180//RNA helicase
  • CTONG20156780//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
  • CTONG20158040//UTP-glucose-1-phosphate uridylyltransferase
  • CTONG20158660//Latrophilin/CL-1-like GPS domain//7 transmembrane receptor (Secretin family)
  • CTONG20159530//Glypican
  • CTONG20160560//DNA binding domain with preference for A/T rich regions
  • CTONG20161850//Immunoglobulin domain
  • CTONG20165050//Keratin, high sulfur B2 protein
  • CTONG20186320//Kelch motif// Kelch motif// Kelch motif// Kelch motif
  • CTONG20200310//RNB-like proteins
  • D3OST20006180//Dual specificity phosphatase, catalytic domain
  • D3OST20036070//Leucine Rich Repeat
  • D9OST20023970//Glycosyl hydrolases family 18//Glycosyl-hydrolases family 18
  • D9OST20026730//Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat
  • D9OST20033970//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Putative zinc finger in N-recognin// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • D9OST20035940//Mitochondrial carrier proteins// Mitochondrial carrier proteins
  • D9OST20040180//7 transmembrane receptor (rhodopsin family)
  • DFNES20037420//Elongation factor Tu family
  • DFNES20071130//Phosphotriesterase family// Phosphotriesterase family// Phosphotriesterase family
  • FCBBF10000240//Phosphoenolpyruvate carboxylase// Bacterial Cytochrome Ubiquinol Oxidas// Glycosyl transferase
  • FCBBF10000630//Molluscan rhodopsin C-terminal tail// WW domain
  • FCBBF10001150//Cadherin domain// Cadherin domain// Cadherin domain// Cadherin domain// Cadherin domain
  • FCBBF10001210//Immunoglobulin domain// Immunoglobulin domain
  • FCBBF10001550//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
  • FCBBF10001710//DM DNA binding domain// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • FCBBF10002800//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • FCBBF10003670//Ubiquitin carboxyl-terminal hydrolases famil
  • FCBBF10003770//PDZ domain (Also known as DHR or GLGF).// PDZ domain (Also known as DHR or GLGF).// pf kB family carbohydrate kinase// PDZ domain (Also known as DHR or GLGF).// ThiC family// PDZ domain (Also known as DHR or GLGF).// PDZ domain (Also known as DHR or GLGF).// PDZ domain (Also known as DHR or GLGF).// TIR domain
  • FCBBF10004120//RNA recognition motif. (a.k.a. RRM, RBD, or
  • FCBBF10004370//KRAB box// Zinc finger, C2H2 type// Ribosomal protein L37e// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • FCBBF10005060//CRAL/TRIO domain.
  • FCBBF10005460//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Fibronectin type III domain// Fibronectin type III domain
  • FCBBF10005500//Keratin, high sulfur B2 protein
  • FCBBF10005740//Mitochondrial carrier proteins// Mitochondrial carrier proteins
  • FCBBF20014270//Acyl CoA binding protein
  • FCBBF20042170//Fibrillar collagen C-terminal domain
  • FCBBF20049300//Olfactomedin-like domain
  • FCBBF20059090//Zinc finger, C2H2 type
  • FCBBF20064520//RNA recognition motif. (a.k.a. RRM, RBD, or
  • FCBBF20067810//Nerve growth factor family// GTP1/OBG family// GTP1/OBG family// GTPase of unknown function// ADP-ribosylation factor family// Ras family
  • FCBBF20068820//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • FCBBF30010810//KRAB box// Rieske [2Fe-2S] domain// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • FCBBF30012350//Eukaryotic protein kinase domain
  • FCBBF30012810//Ubiquitin carboxyl-terminal hydrolases famil
  • FCBBF30015940//Methyl-accepting chemotaxis protein (MCP) signaling domain
  • FCBBF30016320//SecA protein, amino terminal region
  • FCBBF30018550//Oxysterol-binding protein
  • FCBBF30025560//Prolyl oligopeptidase family// Pou domain-N-terminal to homeobox doma// Homeobox domain
  • FCBBF30033050//Sm protein
  • FCBBF30039020//Herpesvirus UL6 like// Growth-Arrest-Specific Protein 2 Domain
  • FCBBF30049550//Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Glutamine amidotransferases class-II// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// ZU5 domain
  • FCBBF30054440//PLAT/LH2 domain
  • FCBBF30057290//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • FCBBF30078290//DNA binding domain with preference for A/T r
  • FCBBF30086440//Pilin (bacterial filament)
  • FCBBF30090690//Leucine rich repeat N-terminal domain// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine rich repeat C-terminal domain
  • FCBBF30095260//DHHC zinc finger domain
  • FCBBF30129630//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • FCBBF30175310//C1q domain// CDP-alcohol phosphatidyltransferase
  • FCBBF30190850//Sushi domain (SCR repeat)// Sushi domain (SCR repeat)// Sushi domain (SCR repeat)// Keratin, high sulfur B2 protein// Sushi domain (SCR repeat)// Phosphate transporter family
  • FCBBF30195640//PHD-finger// CONSTANS family zinc finger// PHD-finger// PHD-finger// Hsp20/alpha crystallin family
  • FCBBF30225660//Ank repeat// Ank repeat// Ank repeat// K+ channel tetramerisation domain// BTB/POZ domain
  • FCBBF30233680//G10 protein
  • FCBBF30238870//Laminin G domain// Thrombospondin N-terminal-like domains// Laminin G domain// von Willebrand factor type C domain// von Willebrand factor type C domain// EGF-like domain// EB module// EGF-like domain// EGF-like domain// Trypsin Inhibitor like cysteine rich domain// Metallothionein// EGF-like domain// EGF-like domain// EGF-like domain
  • FCBBF30240960//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • FCBBF30246630//Leucine Rich Repeat// Leucine Rich Repeat
  • FCBBF30247930//Uncharacterized protein family UPF0004
  • FCBBF30262510//Ank repeat// Fibronectin type III domain
  • FCBBF30281880//Regulator of G protein signaling domain// PX domain
  • FCBBF30285280//Keratin, high sulfur B2 protein// Bacterial regulatory proteins, gntR family
  • FCBBF40001730//WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat
  • FEBRA10001880//Eukaryotic protein kinase domain// Eukaryotic protein kinase domain
  • FEBRA10001900//Zinc finger, C2H2 type
  • FEBRA20004620//Rap/ran-GAP
  • FEBRA20007620//Bacterial type II secretion system protein// DEAD/DEAH box helicase// Helicases conserved C-terminal domain
  • FEBRA20018690//Zinc finger, C2H2 type
  • FEBRA20024100//Ank repeat// Ank repeat// Myosin head (motor domain)// Myosin head (motor domain)
  • FEBRA20025270//Sulfotransferase proteins
  • FEBRA20026110//Dictyostelium (slime mold) repeats// Zinc finger, C2H2 type// Dictyostelium (slime mold) repeats// Zinc finger, C2H2 type// Dictyostelium (slime mold) repeats// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Dictyostelium (slime mold) repeats// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Dictyostelium (slime mold) repeats// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Dictyostelium (slime mold) repeats// Zinc finger, C2H2 type
  • FEBRA20034680//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// DnaJ central domain (4 repeats)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type
  • FEBRA20040530//KRAB box// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Bacterial dnaA protein// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • FEBRA20080810//POT family
  • FEBRA20082010//KRAB box// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • FEBRA20086620//Olfactomedin-like domain
  • FEBRA20088360//Alpha adaptin carboxyl-terminal domai
  • FEBRA20090290//Zinc finger, C3HC4 type (RING finger)
  • FEBRA20092890//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Fibronectin type III domain
  • FEBRA20097310//SAP domain// RNA recognition motif. (a.k.a. RRM, RBD, or
  • FEBRA20111460//Hemagglutinin
  • FEBRA20130190//Galactosyltransferase// Fringe-like
  • FEBRA20132740//PH domain
  • FEBRA20144170//Eukaryotic protein kinase domain// Protein kinase C terminal domain// Eukaryotic protein kinase domain
  • FEBRA20167390//Sialyltransferase family
  • FEBRA20171380//KRAB box// wnt family of developmental signaling protei// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Putative zinc finger in N-recognin// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • FEBRA20184330//PDZ domain (Also known as DHR or GLGF).
  • FEBRA20192420//Cyclin-dependent kinase inhibitor// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif
  • FEBRA20195820//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type
  • FEBRA20196370//Cyclin-dependent kinase inhibitor// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif
  • FEBRA20196630//DEAD/DEAH box helicase// Helicases conserved C-terminal domain
  • FEBRA20214970//Reverse transcriptase (RNA-dependent DNA pol
  • FEBRA20222040//bZIP transcription factor// K-box region
  • FEBRA20223220//EGF-like domain// EGF-like domain// Cadherin domain
  • FEBRA20229630//NADH-Ubiquinone/plastoquinone (complex I)
  • FEBRA20235500//Sodium Bile acid symporter family// ABC 3 transport family
  • FEBRA20237640//SAM domain (Sterile alpha motif)
  • FEHRT20003250//Phosphatidylinositol 3- and 4-kinases
  • HCASM10000500//Ribonucleotide reductases// Nucleotidyltransferase domain
  • HCHON10001760//Histone deacetylase family
  • HCHON20000380//Glucose-6-phosphate dehydrogenase
  • HCHON20003220//Formyl transferase// Phosphopantetheine attachment site// Protein of unknown function DUF132//Aldehyde dehydrogenase family
  • HCHON20007510//Phosphotyrosine interaction domain (PTB/PID)// TBC domain
  • HCHON20008150//RNA recognition motif. (a.k.a. RRM, RBD, or
  • HCHON20008320//Glutamine synthetase// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type
  • HCHON20009560//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • HCHON20010990//TPR Domain
  • HCHON20015350//FtsJ cell division protein
  • HCHON20015980//FG-GAP repeat// von Willebrand factor type A domain
  • HCHON20016040//Insulin-like growth factor binding proteins
  • HCHON20016650//Leucine rich repeat C-terminal domain// Immunoglobulin domain// Latrophilin/CL-1-like GPS domain//7 transmembrane receptor (Secretin family)
  • HCHON20035130//Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • HCHON20036420//Death effector domain
  • HCHON20040020//Syntaxin
  • HCHON20059870//Bromodomain// Bromodomain
  • HCHON20064590//Alpha-2-macroglobulin family N-terminal regi// Alpha-2-macroglobulin family N-terminal regi
  • HCHON20068410//IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif
  • HCHON20086720//Insulin-like growth factor binding pr// Thyroglobulin type-1 repeat
  • HCHON20100740//EGF-like domain// F5/8 type C domain// F5/8 type C domain
  • HEART20003060//Immunoglobulin domain// Immunoglobulin domain
  • HEART20005410//u-PAR/Ly-6 domain
  • HEART20017730//Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat
  • HEART20025980//Calponin homology (CH) domain
  • HEART20034320//Glycosyl hydrolase family 9//Glycosyl hydrolase family 9
  • HEART20061950//PDZ domain (Also known as DHR or GLGF).
  • HEART20077670//Protein phosphatase 2A regulatory B subunit
  • HEART20083640//NAD-dependent DNA ligase
  • HEART20090000//Inositol polyphosphate phosphatase family, c
  • HHDPC10000830//Zinc finger, C3HC4 type (RING finger)
  • HHDPC20014320//Reprolysin family propeptide
  • HHDPC20031130//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • HHDPC20034390//Cereal trypsin/alpha-amylase inhibito
  • HHDPC20034720//Glutathione S-transferases.
  • HHDPC20068620//Immunoglobulin domain// Immunoglobulin domain
  • HHDPC20091780//CUB domain// F5/8 type C domain
  • HHDPC20092080//Thyroglobulin type-1 repeat
  • HLUNG20016330//Methyl-accepting chemotaxis protein (MCP) s// PH domain// PH domain// Methanol dehydrogenase beta subunit
  • HLUNG20017120//Peptidyl-tRNA hydrolase domain
  • HLUNG20023340//KH domain
  • HLUNG20033780//Birnavirus VP3 protein// RhoGEF domain// PH domain// SH3 domain
  • IMR3220002430//WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat
  • KIDNE20002520//tRNA synthetases class I (E and Q)// tRNA synthetases class I (K)// tRNA synthetases class I (E and Q)
  • KIDNE20003940//Phosphotransferase system, EIIC// FecCD transport family// ABC 3 transport family
  • KIDNE20007770//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • KIDNE20008010//Dihydropyridine sensitive L-type calcium
  • KIDNE20009470//G-patch domain// Peptidase family M1
  • KIDNE20017130//MYND finger// DM DNA binding domain// Ribosomal protein L36
  • KIDNE20020150//Ribosomal protein S13/S18//Hsp70 protein
  • KIDNE20021680//3-hydroxyacyl-CoA dehydrogenase
  • KIDNE20022620//Glycosyl transferase family 8
  • KIDNE20024830//C2 domain// C2 domain
  • KIDNE20027250//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • KIDNE20027950//KRAB box
  • KIDNE20028390//Galactose-1-phosphate uridyl transfer// Galactose-1-phosphate uridyl transfer
  • KIDNE20028720//ATP synthase (C/AC39) subunit
  • KIDNE20028830//K-box region
  • KIDNE20100070//AMP-binding enzyme
  • KIDNE20101510//EGF-like domain// Trypsin Inhibitor like cysteine rich d// EGF-like domain// Keratin, high sulfur B2 protein// Zona pellucida-like domain
  • KIDNE20102710//Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat
  • KIDNE20107390//Histone-like transcription factor (CBF/// GHMP kinases putative ATP-binding prote
  • KIDNE20107620//Eukaryotic protein kinase domain// Dihydropyridine sensitive L-type calcium
  • KIDNE20109730//Sodium
  • KIDNE20109890//WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// Zinc finger, C4 type (two domains)// WD domain, G-beta repeat// WD domain, G-beta repeat
  • KIDNE20121880//PMP-22/EMP/MP20/Claudin family
  • KIDNE20125630//ATP1G1/PLM/MAT8 family
  • KIDNE20127100//Kelch motif// Kelch motif// Kelch motif
  • KIDNE20127750//Bacterial regulatory proteins, tetR family
  • KIDNE20137340//Uncharacterized membrane protein family UPFO
  • KIDNE20182690//BAH domain// ELM2 domain
  • LIVER10004790//EF hand
  • LIVER20002160//Hsp70 protein
  • LIVER20035680//UvrD/REP helicase
  • LIVER20055440//RhoGAP domain
  • LIVER20064690//Serpins (serine protease inhibitors)
  • LIVER20080530//Ank repeat// Ank repeat// Ank repeat// SAM domain (Sterile alpha motif)
  • LIVER20087060//Guanylate-binding protein
  • LIVER20087510//PHD-finger
  • MAMGL10000830//LysM domain
  • MESAN10001260//von Willebrand factor type C domain// von Willebrand factor type C domain// von Willebrand factor type C domain// von Willebrand factor type C domain// TILa domain// von Willebrand factor type C domain// Keratin, high sulfur B2 protein// PEP-utilizing enzymes// von Willebrand factor type D domain// Plant PEC family metallothionein// Trypsin Inhibitor like cysteine rich
  • MESAN20029400//Zinc finger, C3HC4 type (RING finger)// RNA polymerases M/15 Kd subunits
  • MESAN20031900//Zinc finger, C3HC4 type (RING finger)// Peroxidase// Zinc finger, C3HC4 type (RING finger)// B-box zinc finger.// Fibronectin type III domain
  • MESAN20035290//FYVE zinc finger
  • MESAN20036460//Corticotropin-releasing factor family
  • MESAN20038510//Oxidoreductase molybdopterin binding d
  • MESAN20101140//LIM domain containing proteins
  • MESAN20103120//Sodium/calcium exchanger protein
  • MESAN20125860//Transferrin
  • MESAN20127350//Zinc knuckle
  • MESAN20130220//‘chromo’ (CHRromatin Organization MOdifier)// Enoyl-CoA hydratase/isomerase family
  • MESAN20136110//KH domain// KH domain// Zinc finger, C3HC4 type (RING finger)
  • MESAN20141920//Troponin// Tropomyosins// Borrelia ORF-A
  • MESAN20154010//Tryptophan synthase alpha chain// Ribulose-phosphate 3 epimerase family// Indole-3-glycerol phosphate synthases
  • MESAN20171520//PH domain
  • MESAN20174170//Regulator of G protein signaling domain
  • MESAN20186700//Hepatitis C virus RNA dependent RNA polymerase
  • NOVAR10000150//Cytosolic long-chain acyl-CoA thioester hydrolase
  • NT2NE20010490//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// DM DNA binding domain// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • NT2NE20021620//Vacuolar sorting protein 9 (VPS9) domain
  • NT2NE20080170//CRAL/TR10 domain.
  • NT2NE20089970//KRAB box
  • NT2NE20118960//Gram-negative pili assembly chaperone
  • NT2NE20125050//Ezrin/radixin/moesin family
  • NT2NE20130190//Zinc finger, C2H2 type
  • NT2NE20132170//GNS1/SUR4 family// Transmembrane amino acid transporter protein
  • NT2NE20142210//PAS domain// PAS domain
  • NT2NE20157470//von Willebrand factor type A domain// Trypsin
  • NT2NE20158600//Ank repeat// Ank repeat
  • NT2NE20177520//Sushi domain (SCR repeat)// Sushi domain (SCR repeat)// Sushi domain (SCR repeat)// Sushi domain (SCR repeat)
  • NT2NE20181650//Src homology domain 2
  • NT2NE20183760//Calcitonin/CGRP/IAPP family
  • NT2NE20184900//FF domain
  • NT2RI20001330//Ank repeat// Ank repeat
  • NT2RI20003480//Glypican
  • NT2RI20005750//Cell division protein// Sigma-54 interaction domain// ADP-ribosylation factor family// ABC transporter// Ras family
  • NT2RI20009870//Fringe-like
  • NT2RI20025640//Reverse transcriptase (RNA-dependent DNA pol
  • NT2RI20040930//Mitochondrial carrier proteins// Mitochondrial carrier proteins
  • NT2RI20040990//Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat
  • NT2RI20046080//recA bacterial DNA recombination proteins
  • NT2RI20048840//ADP-ribosylation factor family// G-protein alpha subunit
  • NT2RI20054050//HSF-type DNA-binding domain
  • NT2RI20056700//Spectrin repeat// Apolipoprotein A1/A4/E family// Olfactomedin-like domain
  • NT2RI20091730//Molluscan rhodopsin C-terminal tail
  • NT2RI20240080//TPR Domain// TPR Domain// TPR Domain
  • NT2RI20244600//PAP2 superfamily
  • NT2RI20273230//DEAD/DEAH box helicase
  • NT2RP60000770//Zinc finger, C2H2 type// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • NT2RP60000850//C2 domain
  • NT2RP70027380//PX domain// SH3 domain// RhoGAP domain
  • NT2RP70032610//Peptidase family M20/M25/M40//Enol-ase
  • NT2RP70036880//TBC domain
  • NT2RP70043480//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • NT2RP70044280//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
  • NT2RP70062230//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Pancreatic hormone peptides// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • NT2RP70063950//RhoGEF domain// Extracellular link domain// PH domain
  • NT2RP70078420//PH domain// Putative GTP-ase activating protein for Arf// Ank repeat// Ank repeat
  • NT2RP70080850//SPRY domain// Adenovirus EB1 55K protein/large t-an
  • NT2RP70102350//Viral methyltransferase// Helix-loop-helix DNA-binding domain
  • NT2RP70105210//Myc amino-terminal region
  • NT2RP70157890//KRAB box
  • NT2RP70159960//PH domain
  • NT2RP70179710//Zinc finger, C3HC4 type (RING finger)// PHD-finger
  • NT2RP70188710//Yeast PIR proteins
  • NT2RP70192730//alpha/beta hydrolase fold
  • NT2RP70194450//Bacterial regulatory proteins, crp family
  • NT2RP70195430//Zinc-binding dehydrogenases
  • NT2RP70198350//PWWP domain
  • NTONG20009770//Coronavirus S2 glycoprotein// Peptidase family M3
  • NTONG20013620//Sulfotransferase proteins
  • NTONG20015870//Transposase// Outer membrane efflux protein// Intermediate filament proteins
  • NTONG20028070//von Willebrand factor type C domain
  • NTONG20029480//NAD-dependent DNA ligase
  • NTONG20029700//Laminin N-terminal (Domain VI)// Laminin EGF-like (Domains III and V)// Laminin EGF-like (Domains III and V)// Laminin EGF-like (Domains III and V)
  • NTONG20046140//Eukaryotic protein kinase domain// Aminoglycoside phosphotransferase
  • NTONG20051530//Mov34/MPN/PAD-1 family// Extracellular link domain// Adhesin lipoprotein// Lectin C-type domain
  • NTONG20056570//WD domain, G-beta repeat// WD domain, G-beta repeat
  • NTONG20063010//EGF-like domain// Trypsin Inhibitor like cysteine rich domain// EGF-like domain// EGF-like domain// Keratin, high sulfur B2 protein// Chitin binding Peritrophin-A domain// Zona pellucida-like domain
  • NTONG20064840//C2 domain// C2 domain
  • NTONG20067830//Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat
  • NTONG20070200//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • NTONG20070340//Collagen triple helix repeat (20 copies)// Collagen triple helix repeat (20 copies)// Collagen triple helix repeat (20 copies)
  • NTONG20075220//RyR domain
  • NTONG20076930//Alpha-2-macroglobulin family
  • NTONG20083650//TPR Domain// TPR Domain// TPR Domain// PPR repeat// TPR Domain// PPR repeat// TPR Domain
  • NTONG20092290//Immunoglobulin domain// Immunoglobulin domain
  • NTONG20092330//Putative membrane protein
  • OCBBF10001850//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// DM DNA binding domain// Zinc finger, C2H2 type// Zinc finger, C2H2 type// MYND finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • OCBBF20019380//Sushi domain (SCR repeat)// CUB domain
  • OCBBF20019830//Fibronectin type III domain// Fibronectin type III domain// EGF-like domain// Metallothionein family 5
  • OCBBF20020830//Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain)// Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain)// Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain)// Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain)// Pumilio family RNA binding domains (aka PUM-HD, Pumilio homology domain)// Putative GTP-ase activating protein for Arf// Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain)// Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain)// Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain)
  • OCBBF20022900//IQ calmodulin-binding motif// Dishevelled specific domain// Kunitz/Bovine pancreatic trypsin inhibitor domain
  • OCBBF20028050//Phorbol esters/diacylglycerol binding domain (C1 domain)// Zinc finger, C3HC4 type (RING finger)// PHD-finger
  • OCBBF20028650//Ank repeat// Ank repeat// Helicases conserved C-terminal domain
  • OCBBF20030280//Lipoprotein amino terminal region
  • OCBBF20035930//NSF attachment protein
  • OCBBF20037440//Zinc finger, C3HC4 type (RING finger)
  • OCBBF20046120//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • OCBBF20049300//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Putative zinc finger in N-recognin// Zinc finger, C2H2 type// DM DNA binding domain// Zinc finger, C2H2 type
  • OCBBF20049840//PDZ domain (Also known as DHR or GLGF).
  • OCBBF20050770//Dehydrins// Carnitate acyltransferase
  • OCBBF20053430//Extracellular link domain// Eukaryotic protein kinase domain// Protein kinase C terminal domain
  • OCBBF20053730//Ank repeat// Ank repeat// Ank repeat// Patatin
  • OCBBF20054760//Death domain
  • OCBBF20059560//UvrB/uvrC motif
  • OCBBF20066390//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • OCBBF20071210//Spectrin repeat
  • OCBBF20071840//Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C3HC4 type (RING finger)// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • OCBBF20079310//Acetyltransferase (GNAT) family
  • OCBBF20080410//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • OCBBF20082830//alpha/beta hydrolase fold
  • OCBBF20086400//ADP-ribosylation factor family// ABC transporter// FtsK/SpoIIIE family// Ras family
  • OCBBF20086910//HMG (high mobility group) box
  • OCBBF20107090//Cadherin domain
  • OCBBF20108190//Zinc finger, C2H2 type// Zinc finger, C2H2 type// IBR domain// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • OCBBF20108430//ADP-ribosylation factor family// G-protein alpha subunit
  • OCBBF20108580//Caspase recruitment domain
  • OCBBF20108630//ABC transporter
  • OCBBF20109310//PH domain// Arrestin (or S-antigen)
  • OCBBF20116850//Leucine rich repeat N-terminal domain// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine rich repeat C-terminal domain// Immunoglobulin domain
  • OCBBF20120390//Caveolin// Hepatitis C virus core protein// Sodium:neurotransmitter symporter family
  • OCBBF20121390//BTB/POZ domain// Kelch motif// Kelch motif// Kelch motif// Kelch motif// Kelch motif
  • OCBBF20124360//CNH domain
  • OCBBF20125530//Vpu protein// Zinc finger, C3HC4 type (RING finger)
  • OCBBF20127040//Interleukin-6/G-CSF/MGF family
  • OCBBF20127140//WD domain, G-beta repeat// WD domain, G-beta repeat
  • OCBBF20127550//Outer Capsid protein VP4 (Hemagglutinin)
  • OCBBF20128120//DnaJ domain// DnaJ central domain (4 repeats)// DnaJ C terminal region
  • OCBBF20129360//PH domain// EF hand// Ribosomal RNA adenine dimethylases// EF hand// Sulfotransferase proteins// Somatotropin hormone family// Phosphatidylinositol-specific phospholi// Phosphatidylinositol-specific phospholi// C2 domain
  • OCBBF20132850//Leucine rich repeat N-terminal domain// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine rich repeat C-terminal domain// Immunoglobulin domain// Fibronectin type III domain
  • OCBBF20140640//Phosphotyrosine interaction domain (PTB/PID)
  • OCBBF20140890//Ribosomal protein L11
  • OCBBF20145760//Glypican
  • OCBBF20148280//Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • OCBBF20148730//BTB/POZ domain// Kelch motif// Kelch motif// Kelch motif// Kelch motif
  • OCBBF20155060//EGF-like domain// Laminin EGF-like (Domains III and V)// Laminin G domain// EGF-like domain// Laminin G domain// EGF-like domain
  • OCBBF20173980//Regulator of chromosome condensation// Regulator of chromosome condensation// Regulator of chromosome condensation// Regulator of chromosome condensation// Regulator of chromosome condensation// BTB/POZ domain// Thymidylate synthase
  • OCBBF20178880//Granulins
  • OCBBF20180120//Sodium:sulfate symporter transmembrane// Sodium:sulfate symporter transmembrane// Sodium:sulfate symporter transmembrane
  • PEBLM10000240//Domain found in Dishevelled, Eg1-10, and Ple
  • PEBLM20013120//PH domain
  • PEBLM20024320//Cation efflux family
  • PEBLM20042900//Chitin synthase
  • PEBLM20044520//Ubiquitin carboxyl-terminal hydrolase fam// Exonuclease
  • PEBLM20052820//Protein phosphatase 2C
  • PEBLM20060310//IBR domain// Zinc finger, C3HC4 type (RING finger)
  • PEBLM20060360//KRAB box
  • PEBLM20075980//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • PEBLM20078320//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// DnaJ central domain (4 repeats)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • PERIC10000250//Prokaryotic DNA topoisomerase
  • PERIC20003870//Ribosomal L32p protein family// NAC domain// TS-N domain
  • PERIC20004220//Domain of unknown function
  • PERIC20004780//bZIP transcription factor
  • PLACE60003480//Chorismate synthase
  • PLACE60060420//Ribosomal protein L44
  • PLACE60079250//Bacterial flagellin N-terminus// Spectrin repeat// Spectrin repeat// Spectrin repeat// Caulimovirus movement protein// Spectrin repeat// Spectrin repeat// Spectrin repeat// UvrB/uvrC motif// Spectrin repeat// Spectrin repeat// Flagellar hook-associated protein 2//Spectrin repeat// KE2 family protein
  • PLACE60136500//dUTPase
  • PLACE60136720//Porphobilinogen deaminase// GHMP kinases putative ATP-binding prot
  • PLACE60177140//7 transmembrane receptor (rhodopsin family)
  • PROST20047270//CRAL/TR10 domain.
  • PROST20047390//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • PROST20050670//Endothelin family
  • PROST20066880//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • PROST20079500//Hepatitis C virus non-structural protein NS4b// Ras association (RalGDS/AF-6) domain
  • PROST20100460//Cystine-knot domain
  • PROST20112970//Sterile alpha motif (SAM)/Pointed domain// SAM domain (Sterile alpha motif)
  • PROST20114390//Integrase DNA binding domain
  • PROST20161950//RasGEF domain
  • PROST20169800//Cytochrome P450
  • PROST20170980//Immunoglobulin domain// Adenovirus E3 region protein CR1
  • PROST20171280//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • PROST20176170//LIM domain containing proteins// LIM domain containing proteins// LIM domain containing proteins
  • PROST20185830//GATA zinc finger
  • PROST20189770//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • PROST20191640//Zinc finger, C3HC4 type (RING finger)// IBR domain// Keratin, high sulfur B2 protein// Zinc finger, C3HC4 type (RING finger)
  • PUAEN10000850//Uncharacterized protein family UPF0025//Sec1 family
  • PUAEN20011880//ZAP domain// Piwi domain
  • PUAEN20015860//PDZ domain (Also known as DHR or GLGF).// Regulator of G protein signaling domain
  • PUAEN20018820//Sterile alpha motif (SAM)/Pointed domain// Ets-domain
  • PUAEN20030180//Eukaryotic-type carbonic anhydrase
  • PUAEN20040670//FERM domain (Band 4.1 family)// FERM domain (Band 4.1 family)
  • PUAEN2055020//PH domain// START domain
  • PUAEN20078980//PH domain// FYVE zinc finger// Domain of unknown function
  • DUF123//PH domain
  • PUAEN20083140//EF hand// PH domain// Neuregulin family
  • PUAEN20108240//Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat
  • SALGL10001710//ENV polyprotein (coat polyprotein)
  • SKMUS20001980//Nebulin repeat// Nebulin repeat// Nebulin repeat// Nebulin repeat// Nebulin repeat// Nebulin repeat
  • SKMUS20003610//Syndecan domain// Mitochondrial carrier proteins// Mitochondrial carrier proteins// Mitochondrial carrier proteins SKMUS20007800//Matrix protein (MA), p15//Prenyltransferase and squalene oxidase re
  • SKMUS20016220//Nebulin repeat// Nebulin repeat// Nebulin repeat// Nebulin repeat// Nebulin repeat// Nebulin repeat// Nebulin repeat// Nebulin repeat// Nebulin repeat
  • SKMUS20018230//Ank repeat
  • SKMUS20018500//Coronavirus S2 glycoprotein
  • SKMUS20024750//Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat
  • SKMUS20029200//Ank repeat// Respiratory-chain NADH dehydrogenase, 4//Ank repeat// Ank repeat// Ank repeat// Ank repeat
  • SKMUS20048970//Actin// Actin
  • SKMUS20049030//Nebulin repeat// Nebulin repeat// Nebulin repeat// Nebulin repeat// Nebulin repeat// Nebulin repeat
  • SKMUS20084740//Syndecan domain
  • SKNSH20008190//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// AN1-like Zinc finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • SKNSH20020540//Arginase family
  • SKNSH20063040//Transmembrane 4 family// Transmembrane 4 family
  • SMINT20001760//PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • SMINT20009840//Immunoglobulin domain// Immunoglobulin domain
  • SMINT20013480//Metallo-beta-lactamase superfamily
  • SMINT20028820//Eukaryotic protein kinase domain
  • SMINT20035690//Ribosomal L29 protein
  • SMINT20049090//Eukaryotic protein kinase domain
  • SMINT20050750//Kazal-type serine protease inhibitor domain
  • SMINT20068010//Kinesin motor domain
  • SMINT20071400//NOL1/NOP2/sun family
  • SMINT20073650//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SMINT20102780//Quinolinate phosphoribosyl transferase
  • SMINT20106290//Formamidopyrimidine-DNA glycosylase
  • SMINT20106720//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SMINT20110330//pKID domain
  • SMINT20112730//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SMINT20115880//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • SMINT20121220//Myosin tail
  • SMINT20121950//2Fe-2S iron-sulfur cluster binding domains
  • SMINT20122910//START domain
  • SMINT20127930//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SMINT20130320//NB-ARC domain// ATPases associated with various cellular act
  • SMINT20131810//ENV polyprotein (coat polyprotein)
  • SMINT20136130//Immunoglobulin domain
  • SMINT20138900//Hr1 repeat motif// Apolipoprotein A1/A4/E family// Intermediate filament proteins
  • SMINT20144430//Immunoglobulin domain
  • SMINT20144800//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • SMINT20152940//Sigma-54 interaction domain// ATPases associated with various cellular activities (AAA)
  • SMINT20154540//Glutathione S-transferases.
  • SMINT20163960//Immunoglobulin domain
  • SMINT20168570//Fasciclin domain
  • SMINT20174360//haloacid dehalogenase-like hydrolase
  • SMINT20177360//RNA recognition motif. (a.k.a. RRM, RBD, or
  • SMINT20179740//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SMINT20183530//ABC transporter// ABC transporter
  • SMINT20190170//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SMINT20191530//DEAD/DEAH box helicase// Helicases conserved C-terminal domain
  • SPLEN20006070//Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat
  • SPLEN20008740//Importin beta binding domain// Armadillo/beta-catenin-like repeats// Armadillo/beta-catenin-like repeats
  • SPLEN20011410//RhoGAP domain
  • SPLEN20026950//SNF2 and others N-terminal domain// Bromodomain// Helicases conserved C-terminal domain// Bromodomain
  • SPLEN20027440//Zinc finger present in dystrophin, CBP/p300//Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat// Ank repeat
  • SPLEN20039240//Ribosomal protein S13/S18//Hsp70 protein
  • SPLEN20054290//Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • SPLEN20077500//PH domain// Transposase
  • SPLEN20079260//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • SPLEN20084600//BTB/POZ domain// Kelch motif// Kelch motif// Kelch motif// Keich motif// Kelch motif
  • SPLEN20095410//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • SPLEN20095550//bZIP transcription factor// bZIP transcription factor// Hpt domain
  • SPLEN20099700//Sigma-54 interaction domain// ATPases associated with various cellular ac// Thymidine kinase from herpesvirus
  • SPLEN20103950//Ribosomal S17
  • SPLEN20118300//Transmembrane amino acid transporter protein
  • SPLEN20119810//Reverse transcriptase (RNA-dependent DNA polymerase)
  • SPLEN20126190//Lipoate-protein ligase B
  • SPLEN20140800//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// DnaJ central domain (4 repeats)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • SPLEN20142100//von Willebrand factor type A domain
  • SPLEN20143180//Src homology domain 2
  • SPLEN20145720//PH domain
  • SPLEN20147110//HECT-domain (ubiquitin-transferase).
  • SPLEN20147390//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • SPLEN20149110//Dishevelled specific domain
  • SPLEN20150940//Histone deacetylase family
  • SPLEN20151210//FERM domain (Band 4.1 family)// FERM domain (Band 4.1 family)// Isocitrate lyase
  • SPLEN20157880//Immunoglobulin domain
  • SPLEN20163560//Kinesin motor domain
  • SPLEN20165310//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SPLEN20170310//PH domain
  • SPLEN20171470//Keratin, high sulfur B2 protein
  • SPLEN20173510//TPR Domain// TPR Domain// TPR Domain// TPR Domain// TPR Domain// NADH-ubiquinone/plastoquinone oxidoreduct
  • SPLEN20174260//Penicillin amidase// Bacterial regulatory proteins, lacI f// Vacuolar sorting protein 9 (VPS9) dom
  • SPLEN20179180//EF hand
  • SPLEN20179810//S-adenosylmethionine synthetase
  • SPLEN20181810//Phorbol esters/diacylglycerol binding domain (C1 domain)// FYVE zinc finger
  • SPLEN20186430//7 transmembrane receptor (rhodopsin family)//7 transmembrane receptor (rhodopsin family)
  • SPLEN20211220//Metalloenzyme superfamily
  • SPLEN20212730//Calpain large subunit, domain III// EF hand// EF hand// EF hand
  • SPLEN20222270//PTB domain (IRS-1 type)
  • SPLEN20245300//Pancreatic hormone peptides
  • SPLEN20250170//RhoGEF domain// PH domain// FYVE zinc finger// Domain of unknown function DUF123//PH domain
  • SPLEN20250390//EF hand// EF hand
  • SPLEN20252190//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type
  • SPLEN20267650//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • SPLEN20292950//Phosphoribulokinase// ABC transporter// Aldehyde oxidase and xanthine dehydrogenase, C terminus
  • SPLEN20304950//Transmembrane 4 family
  • SPLEN20305620//Dihydroorotate dehydrogenase
  • STOMA20001830//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • STOMA20005390//Sodium and potassium ATPases// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • STOMA20005670//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • STOMA20006400//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • STOMA20006780//Hepatitis C virus RNA dependent RNA polymera// Somatotropin hormone family
  • STOMA20008880//Olfactomedin-like domain
  • STOMA20032890//Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • STOMA20034770//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • STOMA20046680//bZIP transcription factor
  • STOMA20056640//Immunoglobulin domain
  • STOMA20056670//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • STOMA20057820//Uncharacterized protein family UPF0024
  • STOMA20062130//Immunoglobulin domain
  • STOMA20063980//Collagen triple helix repeat (20 copies)
  • STOMA20064470//Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat
  • STOMA20069040//Keratin, high sulfur B2 protein
  • STOMA20077450//Repeat in ubiquitin-activating (UBA) pro// Repeat in ubiquitin-activating (UBA) pro
  • STOMA20080500//ABC transporter STOMA20083610//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • STOMA20088380//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • STOMA20092530//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • STOMA20092890//Myosin head (motor domain)
  • SYNOV20001520//Immunoglobulin domain// Immunoglobulin domain
  • SYNOV20001730//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SYNOV20002510//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SYNOV20002790//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SYNOV20002970//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SYNOV20004260//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SYNOV20007000//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SYNOV20008240//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SYNOV20009230//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SYNOV20010880//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SYNOV20011110//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SYNOV20013000//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SYNOV20013560//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SYNOV20013900//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • SYNOV20017080//UBX domain
  • SYNOV30001840//Asparagine synthase// AMP-binding enzyme
  • TBAES20000590//Cytochrome P450// Cytochrome P450
  • TBAES20002550//Peptidase family M1// Sigma-70 factor (ECF subfamily)
  • TBAES20003150//Cytochrome P450
  • TESOP20004000//Papain family cysteine protease
  • TESOP20005270//Sulfotransferase proteins
  • TESTI20001000//Formamidopyrimidine-DNA glycosylase
  • TESTI20001170//HORMA domain
  • TESTI20002780//Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// PEP-utilizing enzymes
  • TESTI20017950//Regulator of G protein signaling domain
  • TESTI20023510//Transcription termination factor nusG
  • TESTI20031810//Bacterial luciferase// Domain of unknown function DUF28
  • TESTI20035960//Coproporphyrinogen III oxidase// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat
  • TESTI20036380//Sulfate transporter family// Sodium Bile acid symporter family// STAS domain
  • TESTI20041690//Zinc finger, C3HC4 type (RING finger)// PHD-finger// IBR domain// Zinc finger, C3HC4 type (RING finger)// B-box zinc finger.// lactate/malate dehydrogenase// Fibronectin type III domain
  • TESTI20044230//Nucleosome assembly protein (NAP)// Nucleosome assembly protein (NAP)// Nucleosome assembly protein (NAP)
  • TESTI20044310//Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Chorismate synthase// UvrB/uvrC motif
  • TESTI20046750//Respiratory-chain NADH dehydrogenase, 4
  • TESTI20057750//RNase H// Integrase Zinc binding domain
  • TESTI20061110//Heavy-metal-associated domain// ATPases associated with various cellular act
  • TESTI20063830//Transposase
  • TESTI20066670//Acyl-CoA dehydrogenase
  • TESTI20067200//K-box region// Homeobox domain
  • TESTI20082330//Tudor domain
  • TESTI20083200//Dual specificity phosphatase, catalytic doma
  • TESTI20083940//Progesterone receptor
  • TESTI20088220//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// BolA-like protein// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Snake toxin// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • TESTI20094470//Ets-domain
  • TESTI20098350//VAT-Nn domain
  • TESTI20108720//Protein phosphatase 2C
  • TESTI20121550//Putative GTP-ase activating protein for Arf
  • TESTI20127760//Cyclin// Calcitonin/CGRP/IAPP family
  • TESTI20130010//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • TESTI20136710//Glypican// PHD-finger
  • TESTI20143390//Integral membrane protein DUF6//Integral membrane protein DUF6
  • TESTI20148000//Thioredoxin// Calsequestrin// Thioredoxin
  • TESTI20152460//Putative zinc finger in N-recognin// PHD-finger
  • TESTI20156100//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • TESTI20157520//K+ channel tetramerisation domain// K+ channel tetramerisation domain
  • TESTI20168480//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// MAM domain.// Immunoglobulin domain
  • TESTI20170350//Cystine-knot domain
  • TESTI20184620//PH domain// Oxysterol-binding protein
  • TESTI20185650//AN1-like Zinc finger
  • TESTI20189410//PHD-finger
  • TESTI20192800//HCO3-transporter family// Ank repeat// Ank repeat// Ank repeat// Alpha-2-macroglobulin family
  • TESTI20197940//Domain of unknown function DUF27//Aconitase family (aconitate hydratase)
  • TESTI20200710//PHD-finger// LIM domain containing proteins
  • TESTI20202650//Repeat in HS1/Cortactin
  • TESTI20204450//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Homeobox domain
  • TESTI20208400//NOL1/NOP2/sun family
  • TESTI20208710//WD domain, G-beta repeat// WD domain, G-beta repeat
  • TESTI20211160//Hydroxyethylthiazole kinase family
  • TESTI20214250//Mitochondrial carrier proteins// Mitochondrial carrier proteins
  • TESTI20215990//F-box domain.// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat
  • TESTI20216370//Carboxylesterases
  • TESTI20226230//Adenylate kinase// Pou domain-N-terminal to homeobox d
  • TESTI20229600//EGF-like domain// Metallothionein family 5//Replication protein// Laminin G domain// EGF-like domain// Laminin G domain// Insulin-like growth factor binding prot// EGF-like domain// Laminin G domain
  • TESTI20230850//PAS domain
  • TESTI20231920//Gag P30 core shell protein
  • TESTI20232140//Phosphatidylinositol-specific phospholipase// Phosphatidylinositol-specific phospholipase
  • TESTI20234140//EF hand// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat// WD domain, G-beta repeat
  • TESTI20234360//WW domain// PPIC-type PPIASE domain.
  • TESTI20238610//MAGE family// Uncharacterized protein family UPF0057
  • TESTI20242830//E2 (early) protein, C terminal// Syndecan domain
  • TESTI20244190//Immunoglobulin domain// Immunoglobulin domain//-Immunoglobulin domain// Immunoglobulin domain
  • TESTI20254860//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Reeler domain// Fibronectin type III domain// Fibronectin type III domain
  • TESTI20255820//FERM domain (Band 4.1 family)// FERM domain (Band 4.1 family)// Isocitrate lyase
  • TESTI20258460//PH domain
  • TESTI20265970//Guanylate-binding protein
  • TESTI20266740//Nucleotidyltransferase domain
  • TESTI20272960//7 transmembrane receptor (rhodopsin family)
  • TESTI20275030//WD domain, G-beta repeat// WD domain, G-beta repeat
  • TESTI20288910//SH3 domain
  • TESTI20291960//Rhomboid family
  • TESTI20303220//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Fibronectin type III domain// Alphaherpesvirus glycoprotein E// Fibronectin type III domain// Fibronectin type III domain// Fibronectin type III domain
  • TESTI20303360//ENV polyprotein (coat polyprotein)
  • TESTI20305540//Hantavirus nucleocapsid protein// Troponin// Apolipoprotein A1/A4/E family
  • TESTI20308600//Homeobox domain
  • TESTI20309170//TPR Domain// Zinc finger, C3HC4 type (RING finger)// Aldo/keto reductase family// ATP-dependent protease La (LON) domain
  • TESTI20314180//Trypsin// Trypsin
  • TESTI20317600//Terpene synthase family
  • TESTI20318090//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • TESTI20320440//Thioredoxin
  • TESTI20320670//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)// RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
  • TESTI20326810//RanBP1 domain.
  • TESTI20327680//EF hand// EF hand
  • TESTI20328280//KE2 family protein// Troponin
  • TESTI20333000//Immunoglobulin domain// Immunoglobulin domain
  • TESTI20334410//DEAD/DEAH box helicase// Helicases conserved C-terminal domain
  • TESTI20335050//Zinc finger, C3HC4 type (RING finger)
  • TESTI20335200//Immunoglobulin domain
  • TESTI20343070//Transcription factor E2F/dimerisation partner (TDP)
  • TESTI20351830//K-box region
  • TESTI20352620//Saposin A-type domain
  • TESTI20355020//Tudor domain
  • TESTI20358980//Homeobox domain// Collagen triple helix repeat (20 copies)
  • TESTI20366910//Pyridine nucleotide-disulphide oxidoreductase
  • TESTI20368330//Rhodanese-like domain
  • TESTI20369690//PHD-finger
  • TESTI20370020//Bleomycin resistance protein
  • TESTI20370810//Ion transport protein// Polysaccharide biosynthesis protein// Sugar (and other) transporter
  • TESTI20371030//Kelch motif// Kelch motif// Kelch motif// Kelch motif// Kelch motif
  • TESTI20375340//Phosphatidylinositol-specific phospholi// UvrD/REP helicase// Phosphatidylinositol-specific phospholi// C2 domain
  • TESTI20377230//Thymidylate synthase
  • TESTI20378190//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • TESTI20381040//Putative zinc finger in N-recognin
  • TESTI20382750//Kinesin motor domain
  • TESTI20383880//DnaJ domain
  • TESTI20385960//Zinc finger, C3HC4 type (RING finger)// SPRY domain
  • TESTI20390410//Arsenical pump membrane protein
  • TESTI20391210//IQ calmodulin-binding motif
  • TESTI20391770//Domain of unknown function DUF19//Thioredoxin
  • TESTI20392250//PH domain// Phorbol esters/diacylglycerol binding domain (C1 domain)
  • TESTI20392270//Cyclin
  • TESTI20392760//Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat
  • TESTI20393530//Mitochondrial carrier proteins
  • TESTI20397760//E1-E2 ATPase
  • TESTI20400940//K-box region
  • TESTI20401020//Mitochondrial carrier proteins// Mitochondrial carrier proteins
  • TESTI20408150//Keratin, high sulfur B2 protein
  • TESTI20416640//Choline/ethanolamine kinase
  • TESTI20432750//Cytochrome C and Quinol oxidase polypeptide
  • TESTI20432820//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • TESTI20436560//Spectrin repeat// Intermediate filament proteins// Intermediate filament tail domain
  • TESTI20442760//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • TESTI20443090//SAP domain// Zinc knuckle// Zinc finger, C3HC4 type (RING finger)
  • TESTI20444130//ENV polyprotein (coat polyprotein)
  • TESTI20449200//7 transmembrane receptor (metabotropic gluta
  • TESTI20451990//SAP domain
  • TESTI20455090//Intermediate filament proteins
  • TESTI20455620//Hsp70 protein
  • TESTI20456110//B-box zinc finger.// Spectrin repeat// SPRY domain
  • TESTI20463580//Ubiquitin carboxyl-terminal hydrolases famil// Immunoglobulin domain// Ubiquitin carboxyl-terminal hydrolase family
  • TESTI20467320//Wiskott Aldrich syndrome homology region 2
  • TESTI20467970//Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain
  • TESTI20471410//Protein phosphatase 2C
  • TESTI20478850//Herpesvirus Glycoprotein B
  • THYMU10005360//Immunoglobulin domain// Viral coat protein// Immunoglobulin domain
  • THYMU10005540//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • THYMU20023380//Copper/zinc superoxide dismutase (SODC)
  • THYMU20027560//Domain of unknown function
  • THYMU20039810//MAC/Perforin domain
  • THYMU20105190//Myosin head (motor domain)
  • THYMU20106710//Immunoglobulin domain
  • THYMU20111180//Domain of unknown function DUF27//Aconitase family (aconitate hydratase)
  • THYMU20115850//Reverse transcriptase (RNA-dependent DNA pol
  • THYMU20118520//Ubiquitin family
  • THYMU20122730//VHS domain
  • THYMU20126900//3-hydroxyacyl-CoA dehydrogenase// UDP-glucose/GDP-mannose dehydrogenase fa
  • THYMU20130890//Ribosomal protein S9/S16
  • THYMU20141670//Phorbol esters/diacylglycerol binding dom// PHD-finger// FYVE zinc finger
  • THYMU20142040//Wiskott Aldrich syndrome homology region 2
  • THYMU20143270//Cytochrome C oxidase subunit II
  • THYMU20147770//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • THYMU20159430//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • THYMU20161640//PMP-22/EMP/MP20/Claudin family// Integral membrane protein DUF6
  • THYMU20169680//Ank repeat// Ank repeat
  • THYMU20172150//WD domain, G-beta repeat
  • THYMU20194360//Kelch motif
  • THYMU20201980//PH domain// Phorbol esters/diacylglycerol binding domain (C1 domain)// FYVE zinc finger// PH domain
  • THYMU20202890//Eukaryotic protein kinase domain
  • THYMU20209590//PH domain// Dynamin GTPase effector domain
  • THYMU20216840//PHD-finger
  • THYMU20229220//Closterovirus coat protein
  • THYMU20239000//Collagen triple helix repeat (20 copies)
  • THYMU20240710//tRNA synthetases class I (E and Q)
  • THYMU20241850//Class II histocompatibility antigen, beta// Immunoglobulin domain
  • THYMU20247480//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • THYMU20279750//Immunoglobulin domain
  • TKIDN10000010//Mitochondrial import inner membrane transloc
  • TKIDN20004640//GHMP kinases putative ATP-binding protei
  • TKIDN20047480//Eukaryotic protein kinase domain
  • TOVAR20004760//Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat
  • TRACH20002870//PMP-22/EMP/MP20/Claudin family
  • TRACH20003590//Cytochrome P450
  • TRACH20005020//Ank repeat// MutT-like domain
  • TRACH20005400//ADP-ribosylation factor family// Ras family
  • TRACH20016210//Fucosyl transferase
  • TRACH20019960//Na+/K+ ATPase C-terminus
  • TRACH20028030//DnaJ domain// DnaJ central domain (4 repeats)// DnaJ C terminal region
  • TRACH20033230//Nucleoside transporter// Sugar (and other) transporter// Influenza RNA-dependent RNA polymerase subunit PB2
  • TRACH20041830//Thioredoxin// Thioredoxin
  • TRACH20042920//Glutamine synthetase
  • TRACH20048450//Phospholipase D. Active site motif// Phospholipase D. Active site motif
  • TRACH20050040//Plexin repeat
  • TRACH20067620//Core-2/1-Branching enzyme
  • TRACH20069180//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • TRACH20076740//Reduced folate carrier
  • TRACH20076760//Keratin, high sulfur B2 protein
  • TRACH20077540//Zinc finger, C2H2 type// G-patch domain
  • TRACH20079690//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type//
  • TRAF-type zinc finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • TRACH20084720//tRNA synthetases class I (C)// tRNA synthetases class I (I, L, M and V)
  • TRACH20085400//Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • TRACH20085830//Cytochrome P450
  • TRACH20096610//Intermediate filament proteins// Intermediate filament tail domain
  • TRACH20105870//Regulatory subunit of type II PKA R-subunit// eIF4-gamma/eIF5/eIF2-epsilon
  • TRACH20121380//Raf-like Ras-binding domain// Leptin// Raf-like Ras-binding domain// LGN motif, putative GEF specific for G-alpha GTPase
  • TRACH20128230//Immunoglobulin domain// Chitin synthase// Immunoglobulin domain// Immunoglobulin domain// Immunoglobulin domain
  • TRACH20135520//TBC domain// Rhodanese-like domain
  • TRACH20136710//Immunoglobulin domain
  • TRACH20141240//Granulins
  • TRACH20145440//von Willebrand factor type D domain
  • TRACH20154860//Squash family of serine protease inhibito// Zinc finger, C4 type (two domains)// T-box// Zinc finger, C4 type (two domains)// Ligand-binding domain of nuclear hormone
  • TRACH20163170//Homeobox domain
  • TRACH20164980//Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// PHD-finger// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • TRACH20167220//wnt family of developmental signaling protei// PLAT/LH2 domain// Fibroblast growth factor
  • TRACH20184490//KRAB box// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • TRACH20190240//EGF-like domain// EGF-like domain// Trypsin Inhibitor like cysteine rich domain// EGF-like domain
  • TSTOM20005690//BTB/POZ domain// Kelch motif// Kelch motif// Kelch motif
  • TUTER20002830//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
  • UMVEN10001860//PH domain// RhoGAP domain// bZIP transcription factor
  • UMVEN20000690//F5/8 type C domain
  • UTERU20030570//ABC 3 transport family// Voltage gated chloride channels// CBS domain// CBS domain
  • UTERU20046640//Rotavirus NS26
  • UTERU20046980//EB module// TNFR/NGFR cysteine-rich region// Furin-like cysteine rich region// Thrombospondin type 1 domain
  • UTERU20050690//Androgen receptor
  • UTERU20055330//Reverse transcriptase (RNA-dependent DNA polymerase)
  • UTERU20055480//AMP-binding enzyme
  • UTERU20055930//Helper component proteinase
  • UTERU20064000//Peptidase family M1
  • UTERU20065930//Hr1 repeat motif// PDZ domain (Also known as DHR or GLGF).
  • UTERU20115740//KRAB box
  • UTERU20116570//Villin headpiece domain
  • UTERU20119060//ADP-ribosyl cyclase
  • UTERU20144640//Choloylglycine hydrolase
  • UTERU20145480//KRAB box// Zinc finger, C2H2 type// Transcription factor S-II (TFIIS)// Zinc finger, C2H2 type// TRAF-type zinc finger// Zinc finger, C2H2 type// Zinc finger, C2H2 type// wnt family of developmental signaling proteins// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type// Zinc finger, C2H2 type
  • UTERU20146310//Diacylglycerol kinase accessory domain (pres
  • UTERU20161570//7 transmembrane receptor (rhodopsin family)
  • UTERU20168220//Cell division protein// Integrase Zinc binding domain// GTPase of unknown function
  • UTERU20176130//Putative GTP-ase activating protein for Arf
  • UTERU20176320//SMC domain N terminal domain// Tropomyosins
  • UTERU20178100//Aminotransferases class-III pyridoxal-pho
  • UTERU20179880//TPR Domain// TPR Domain// TPR Domain// TPR Domain
  • UTERU20183640//Immunoglobulin domain
  • UTERU20185230//DUP family of yeast membrane proteins
    • EXAMPLE 6 Functional Categorization Based on the Full-Length Nucleotide Sequences
  • The functional prediction and categorization of the proteins encoded by the clones were carried out based on the result of homology search of the databases of GenBank, Swiss-Prot, UniGene and nr (see the Homology Search Result Data) for the full-length nucleotide sequences and the result of domain search of the amino acid sequences deduced from the full-length nucleotide sequences (see Example 5).
  • The clone predicted to belong to the category of secretory protein/membrane protein means a clone having hit data with some annotation, such as growth factor, cytokine, hormone, signal, transmembrane, membrane, extracellular matrix, receptor, G-protein coupled receptor, ionic channel, voltage-gated channel, calcium channel, cell adhesion, collagen, connective tissue, etc., suggesting that it is a secretory or membrane protein, or means a clone in which the presence of nucleotide sequence encoding a signal sequence or transmembrane domain was suggested by the results of PSORT and SOSUI analyses for deduced ORF.
  • The clone predicted to belong to the category of glycoprotein-related protein means a clone having hit data with some annotation, such as glycoprotein, suggesting that the clone encodes a glycoprotein-related protein.
  • The clone predicted to belong to the category of signal transduction-related protein means a clone having hit data with some annotation, such as serine/threonine-protein kinase, tyrosine-protein kinase, SH3 domain, SH2 domain, etc., suggesting that the clone encodes a signal transduction-related protein.
  • The clone predicted to belong to the category of transcription-related protein means a clone having hit data with some annotation, such as transcription regulation, zinc finger, homeobox, etc., suggesting that the clone encodes a transcription-related protein.
  • The clone predicted to belong to the category of disease-related protein means a clone having hit data with some annotation, such as disease mutation, syndrome, etc., suggesting that the clone encodes a disease-related protein, or means a clone whose full-length nucleotide sequence has hit data for Swiss-Prot, GenBank, or UniGene, where the hit data corresponds to genes or proteins which have been deposited in the Online Mendelian Inheritance in Man (OMIM) (http://www.ncbi.nlm.nih.gov/Omim/), which is the human gene and disease database.
  • The clone predicted to belong to the category of enzyme and/or metabolism-related protein means a clone having hit data with some annotation, such as metabolism, oxidoreductase, E. C. No. (Enzyme commission number), etc., suggesting that the clone encodes an enzyme and/or metabolism-related protein.
  • The clone predicted to belong to the category of cell division and/or cell proliferation-related protein means a clone having hit data with some annotation, such as cell division, cell cycle, mitosis, chromosomal protein, cell growth, apoptosis, etc., suggesting that the clone encodes a cell division and/or cell proliferation-related protein.
  • The clone predicted to belong to the category of cytoskeleton-related protein means a clone having hit data with some annotation, such as structural protein, cytoskeleton, actin-binding, microtubles, etc., suggesting that the clone encodes a cytoskeleton-related protein.
  • The clone which is predicted to belong to the category of nuclear protein and/or RNA synthesis-related protein means a clone having hit data with some annotation, such as nuclear protein, RNA splicing, RNA processing, RNA helicase, polyadenylation, etc., suggesting that the clone encodes a nuclear protein and/or RNA synthesis-related protein.
  • The clone predicted to belong to the category of protein synthesis and/or transport-related protein means a clone having hit data with some annotation, such as translation regulation, protein biosynthesis, amino-acid biosynthesis, ribosomal protein, protein transport, signal recognition particle, etc., suggesting that the clone encodes a protein synthesis and/or transport-related protein.
  • The clone predicted to belong to the category of cellular defense-related protein means a clone having hit data with some annotation, such as heat shock, DNA repair, DNA damage, etc., suggesting that the clone encodes a cellular defense-related protein.
  • The clone predicted to belong to the category of development and/or differentiation-related proteins means a clone having hit data with some annotation, such as developmental protein, etc., suggesting that the clone encodes a development and/or differentiation-related protein.
  • The clone predicted to belong to the category of DNA-binding and/or RNA-binding protein means a clone having hit data with some annotation, such as DNA-binding, RNA-binding, etc.
  • The clone predicted to belong to the category of ATP-binding and/or GTP-binding protein means a clone having hit data with some annotation, such as ATP-binding, GTP-binding, etc.
  • In this functional categorization, when a single clone corresponded to multiple categories of those shown above, the clone was assigned to the multiple categories. However, the function of a protein is not restricted to the functional category in this classification, and there is the possibility that other functions are newly assigned to the protein.
  • The clones predicted to belong to the category of secretory protein and/or membrane protein are the following 632 clones.
  • ADIPS10000640, ADRGL10001470, ADRGL20013520, ADRGL20018540, ADRGL20035850, ASTRO20001410, ASTRO20005330, ASTRO20033160, ASTRO20055750, ASTRO20058630, ASTRO20190390, BEAST20004540, BGGI110000240, BNGH420088500, BRACE20006400, BRACE20038000, BRACE20038470, BRACE20039040, BRACE20039540, BRACE20051380, BRACE20053630, BRACE20059370, BRACE20060550, BRACE20061050, BRACE20063630, BRACE20067430, BRACE20069090, BRACE20081720, BRACE20101700, BRACE20101710, BRACE20116110, BRACE20147800, BRACE20153680, BRACE20163350, BRACE20179340, BRACE20188470, BRACE20195100, BRACE20201570, BRACE20210140, BRACE20224480, BRACE20224500, BRACE20228480, BRACE20232840, BRACE20238000, BRACE20273890, BRACE20274080, BRALZ20013500, BRALZ20054710, BRALZ20064740, BRALZ20069760, BRALZ20073760, BRALZ20077930, BRAMY20000860, BRAMY20002770, BRAMY20025840, BRAMY20039260, BRAMY20060920, BRAMY20063970, BRAMY20111960, BRAMY20112800, BRAMY20124260, BRAMY20134140, BRAMY20135900, BRAMY20136210, BRAMY20144620, BRAMY20152110, BRAMY20174550, BRAMY20181220, BRAMY20195090, BRAMY20211390, BRAMY20211420, BRAMY20215230, BRAMY20218250, BRAMY20218670, BRAMY20229800, BRAMY20231720, BRAMY20247280, BRAMY20252180, BRAMY20273960, BRAMY20277170, BRAMY20284910, BRAMY20285160, BRAWH20015350, BRAWH20015890, BRAWH20016860, BRAWH20018730, BRAWH20030250, BRAWH20064050, BRAWH20110790, BRAWH20112940, BRAWH20117950, BRAWH20118230, BRAWH20121640, BRAWH20122580, BRAWH20132190, BRCAN20064010, BRCAN20071190, BRCAN20091560, BRCAN20103740, BRCAN20224720, BRCAN20273550, BRCAN20280360, BRCAN20285450, BRCOC10000870, BRCOC20004040, BRCOC20006370, BRCOC20041750, BRCOC20077690, BRCOC20078640, BRCOC20090520, BRCOC20101230, BRCOC20107300, BRCOC20114180, BRCOC20121720, BRCOC20134480, BRCOC20136750, BRHIP10001290, BRHIP20000870, BRHIP20003120, BRHIP20103090, BRHIP20111200, BRHIP20118380, BRHIP20118910, BRHIP20121410, BRHIP20135100, BRHIP20174040, BRHIP20179200, BRHIP20183690, BRHIP20191490, BRHIP20191770, BRHIP20198190, BRHIP20207430, BRHIP20208270, BRHIP20208590, BRHIP20217620, BRHIP20233090, BRHIP20234380, BRHIP20238880, BRHIP20283030, BRHIP30004570, BRSSN20003120, BRSSN20043040, BRSSN20066110, BRSSN20120810, BRSSN20137020, BRSSN20142940, BRSSN20146100, BRSSN20151990, BRSSN20169050, BRSTN20002200, BRTHA20004740, BRTHA20046290, BRTHA20046420, COLON10001350, COLON20093370, CTONG10000100, CTONG10000940, CTONG10001650, CTONG20004690, CTONG20009770, CTONG20092570, CTONG20092580, CTONG20095340, CTONG20099380, CTONG20103480, CTONG20105080, CTONG20114740, CTONG20119200, CTONG20120770, CTONG20124730, CTONG20131490, CTONG20132220, CTONG20133480, CTONG20139340, CTONG20149950, CTONG20155400, CTONG20158660, CTONG20159530, CTONG20161850, CTONG20267700, D3OST10001090, D3OST20036070, D3OST20038560, D3OST30002580, D6OST20005070, D9OST20002780, D9OST20015470, D9OST20023970, D9OST20026730, D9OST20035940, D9OST20040180, DFNES20025880, FCBBF10000240, FCBBF10000380, FCBBF10001150, FCBBF10001210, FCBBF10001550, FCBBF10002430, FCBBF10002700, FCBBF10003220, FCBBF10003760, FCBBF10005460, FCBBF10005740, FCBBF20032970, FCBBF20042560, FCBBF20049300, FCBBF20051220, FCBBF30008470, FCBBF30024750, FCBBF30078290, FCBBF30083620, FCBBF30086440, FCBBF30090690, FCBBF30095260, FCBBF30123470, FCBBF30172550, FCBBF30175310, FCBBF30190850, FCBBF30215060, FCBBF30238870, FCBBF30251420, FCBBF30279030, FEBRA20002100, FEBRA20004620, FEBRA20009090, FEBRA20029860, FEBRA20037260, FEBRA20080810, FEBRA20086620, FEBRA20092890, FEBRA20093520, FEBRA20095880, FEBRA20111460, FEBRA20125070, FEBRA20130190, FEBRA20140100, FEBRA20145780, FEBRA20211710, FEBRA20223220, FEBRA20229630, FEBRA20235500, HCHON20000380, HCHON20008180, HCHON20015980, HCHON20016040, HCHON20016650, HCHON20040020, HCHON20064590, HCHON20067700, HCHON20068710, HCHON20086720, HCHON20100740, HEART20003060, HEART20005410, HEART20034320, HEART20049410, HEART20049800, HEART20072310, HHDPC20001040, HHDPC20014320, HHDPC20034720, HHDPC20068620, HHDPC20084140, HHDPC20091780, HHDPC20092080, HLUNG10000550, KIDNE20003940, KIDNE20007770, KIDNE20011400, KIDNE20021910, KIDNE20022620, KIDNE20100070, KIDNE20101510, KIDNE20109730, KIDNE20121880, KIDNE20125630, KIDNE20126010, KIDNE20126130, KIDNE20127450, KIDNE20130450, KIDNE20131580, KIDNE20137340, KIDNE20181660, LIVER20035110, LIVER20045650, LIVER20055200, LIVER20062510, LIVER20064690, LIVER20075680, LIVER20087060, LIVER20091180, MESAN10001260, MESAN20014500, MESAN20027090, MESAN20038510, MESAN20089360, MESAN20103120, MESAN20115970, MESAN20125860, MESAN20139360, MESAN20152770, MESAN20153910, MESAN20174170, NOVAR20000380, NT2NE20010050, NT2NE20021620, NT2NE20068130, NT2NE20118960, NT2NE20124480, NT2NE20131890, NT2NE20132170, NT2NE20155110, NT2NE20156260, NT2NE20157470, NT2NE20159740, NT2NE20177520, NT2NE20183760, NT2RI20003480, NT2RI20023910, NT2RI20025400, NT2RI20028470, NT2RI20040930, NT2RI20054050, NT2RI20056700, NT2RI20076290, NT2RI20086220, NT2RI20091940, NT2RI20244600, NT2RP70072690, NT2RP70081610, NT2RP70122910, NT2RP70125160, NT2RP70133740, NT2RP70134990, NT2RP70137290, NT2RP70179710, NT2RP70188020, NT2RP70192730, NT2RP70198350, NTONG20028070, NTONG20029700, NTONG20048060, NTONG20049910, NTONG20051530, NTONG20061870, NTONG20063010, NTONG20067830, NTONG20076930, NTONG20092330, OCBBF10001750, OCBBF20013890, OCBBF20019830, OCBBF20023570, OCBBF20026630, OCBBF20046690, OCBBF20050770, OCBBF20059560, OCBBF20063320, OCBBF20071210, OCBBF20072320, OCBBF20080050, OCBBF20086400, OCBBF20086910, OCBBF20087010, OCBBF20088140, OCBBF20091150, OCBBF20107090, OCBBF20108630, OCBBF20116850, OCBBF20120390, OCBBF20122620, OCBBF20130910, OCBBF20132850, OCBBF20145760, OCBBF20155060, OCBBF20178880, OCBBF20180120, OCBBF20180840, OCBBF20188730, PANCR10000910, PEBLM10000710, PEBLM20024320, PEBLM20040150, PEBLM20074370, PEBLM20075980, PERIC20004220, PLACE60086400, PLACE60121080, PLACE60161600, PLACE60177140, PROST20005050, PROST20050670, PROST20107820, PROST20116600, PROST20120160, PROST20127800, PROST20146010, PROST20164440, PROST20169800, PROST20170980, PROST20175290, PUAEN20003740, PUAEN20030180, SALGL10001710, SKMUS20003610, SKMUS20007800, SKMUS20011640, SKMUS20020840, SKMUS20028210, SKMUS20028400, SKMUS20077400, SKNSH20028660, SKNSH20031740, SKNSH20051940, SKNSH20063040, SMINT20009840, SMINT20011990, SMINT20022020, SMINT20029760, SMINT20040860, SMINT20050750, SMINT20053870, SMINT20073650, SMINT20095050, SMINT20100680, SMINT20105330, SMINT20106720, SMINT20121950, SMINT20127930, SMINT20144430, SMINT201448.90, SMINT20153260, SMINT20154540, SMINT20157450, SMINT20173240, SMINT20178550, SMINT20191420, SMINT20192000, SPLEN20003070, SPLEN20021660, SPLEN20029310, SPLEN20079510, SPLEN20095810, SPLEN20097330, SPLEN20118300, SPLEN20141360, SPLEN20141990, SPLEN20142100, SPLEN20144520, SPLEN20152760, SPLEN20157880, SPLEN20165310, SPLEN20167200, SPLEN20169220, SPLEN20169720, SPLEN20171890, SPLEN20172120, SPLEN20179810, SPLEN20186430, SPLEN20211570, SPLEN20211940, SPLEN20213830, SPLEN20273950, SPLEN20292950, SPLEN20293800, SPLEN20304950, SPLEN20329240, STOMA20005390, STOMA20005670, STOMA20006400, STOMA20006780, STOMA20008880, STOMA20051200, STOMA20056640, STOMA20056670, STOMA20062130, STOMA20077450, STOMA20080500, STOMA20088380, STOMA20092530, SYNOV20001520, SYNOV20001730, SYNOV20002510, SYNOV20002790, SYNOV20002970, SYNOV20004260, SYNOV20007000, SYNOV20008240, SYNOV20009230, SYNOV20010880, SYNOV20011110, SYNOV20013000, SYNOV20013560, SYNOV20013900, SYNOV30001840, TBAES20003150, TESOP20004000, TESOP20005690, TESTI20001720, TESTI20036380, TESTI20037560, TESTI20094120, TESTI20110280, TESTI20123080, TESTI20123560, TESTI20128350, TESTI20136100, TESTI20136710, TESTI20143390, TESTI20148000, TESTI20164100, TESTI20193360, TESTI20209810, TESTI20209990, TESTI20211220, TESTI20214250, TESTI20216370, TESTI20230250, TESTI20231940, TESTI20242990, TESTI20244190, TESTI20254220, TESTI20254860, TESTI20265970, TESTI20271850, TESTI20272960, TESTI20284880, TESTI20291310, TESTI20291960, TESTI20303220, TESTI20303360, TESTI20303420, TESTI20307700, TESTI20309170, TESTI20314180, TESTI20316870, TESTI20333000, TESTI20335200, TESTI20347180, TESTI20347300, TESTI20352620, TESTI20357960, TESTI20370810, TESTI20373820, TESTI20383880, TESTI20390260, TESTI20390410, TESTI20391770, TESTI20393530, TESTI20396130, TESTI20397760, TESTI20401020, TESTI20401280, TESTI20415170, TESTI20421490, TESTI20422640, TESTI20441940, TESTI20442760, TESTI20444130, TESTI20444180, TESTI20449200, TESTI20463520, TESTI20463580, TESTI20465350, THYMU10005360, THYMU10005540, THYMU20027560, THYMU20032870, THYMU20039810, THYMU20066100, THYMU20081490, THYMU20100410, THYMU20106710, THYMU20111830, THYMU20141670, THYMU20147770, THYMU20159430, THYMU20161640, THYMU20162190, THYMU20173980, THYMU20194420, THYMU20208300, THYMU20216840, THYMU20222890, THYMU20229220, THYMU20241850, THYMU20277390, TKIDN20005210, TRACH20002870, TRACH20003590, TRACH20016210, TRACH20019960, TRACH20029540, TRACH20033230, TRACH20034840, TRACH20042920, TRACH20050040, TRACH20067620, TRACH20068660, TRACH20069180, TRACH20076740, TRACH20085400, TRACH20085830, TRACH20109650, TRACH20111130, TRACH20121380, TRACH20128110, TRACH20128230, TRACH20134950, TRACH20136710, TRACH20139820, TRACH20140820, TRACH20145440, TRACH20168350, TRACH20180840, TRACH20190240, UMVEN20000690, UTERU20030570, UTERU20040610, UTERU20046980, UTERU20055480, UTERU20064860, UTERU20076390, UTERU20094350, UTERU20135860, UTERU20144640, UTERU20158300, UTERU20158800, UTERU20161570, UTERU20178100, UTERU20183640, UTERU20186740
  • The clones predicted to belong to the category of glycoprotein-related protein are the following 128 clones.
  • ADIPS10000640, BRACE20059370, BRACE20163350, BRAMY20277170, BRAMY20285160, BRAWH20064050, BRAWH20112940, BRAWH20117950, BRAWH20118230, BRCAN20103740, BRCOC20004040, BRCOC20006370, BRHIP10001290, BRHIP20103090, BRHIP20283030, BRHIP30004570, BRSSN20003120, BRSSN20146100, BRTHA20046290, COLON10001350, CTONG20159530, D9OST20023970, D9OST20040180, FCBBF10001150, FCBBF20049300, FCBBF30024750, FCBBF30083620, FCBBF30190850, FCBBF30238870, FEBRA20086620, FEBRA20092890, HCHON20015980, HCHON20016040, HCHON20064590, HCHON20086720, HCHON20100740, HEART20003060, HHDPC20014320, HHDPC20068620, HHDPC20092080, KIDNE20003940, KIDNE20007770, KIDNE20101510, LIVER20064690, MESAN20125860, NT2NE20118960, NT2NE20157470, NT2NE20177520, NT2RI20003480, NT2RI20056700, NT2RP70192730, NTONG20051530, NTONG20076930, OCBBF20107090, OCBBF20108630, OCBBF20120390, OCBBF20145760, OCBBF20155060, PLACE60177140, SMINT20050750, SMINT20073650, SMINT20105330, SMINT20106720, SMINT20112730, SMINT20127930, SMINT20153260, SMINT20179740, SMINT20190170, SPLEN20021660, SPLEN20142100, SPLEN20157880, SPLEN20165310, SPLEN20179810, SPLEN20186430, STOMA20001830, STOMA20005390, STOMA20005670, STOMA20006400, STOMA20008880, STOMA20034770, STOMA20056640, STOMA20056670, STOMA20083610, STOMA20088380, STOMA20092530, SYNOV20001520, SYNOV20001730, SYNOV20002510, SYNOV20002790, SYNOV20002970, SYNOV20004260, SYNOV20007000, SYNOV20008240, SYNOV20009230, SYNOV20010880, SYNOV20011110, SYNOV20013000, SYNOV20013560, SYNOV20013900, TESOP20004000, TESTI20136100, TESTI20216370, TESTI20244190, TESTI20254860, TESTI20303220, TESTI20335200, TESTI20352620, TESTI20358980, TESTI20442760, TESTI20449200, TESTI20455090, THYMU10005360, THYMU10005540, THYMU20147770, THYMU20159430, THYMU20241850, TRACH20016210, TRACH20050040, TRACH20067620, TRACH20069180, TRACH20076740, TRACH20128230, UTERU20046980, UTERU20064860, UTERU20144640, UTERU20158800, UTERU20161570, UTERU20183640
  • The clones predicted to belong to the category of signal transduction-related protein are the following 84 clones.
  • ASTRO20108190, BRACE20115920, BRACE20154120, BRACE20177200, BRACE20237270, BRAMY20104640, BRAMY20242470, BRAMY20271400, BRAWH20016620, BRAWH20103290, BRAWH20149340, BRCOC20021550, BRCOC20091960, BRHIP20189980, BRHIP20218580, BRHIP20238600, BRSSN20038200, CD34C30004240, CTONG20118150, CTONG20127450, CTONG20200310, FCBBF30012350, FCBBF40001730, FEBRA10001880, FEBRA20004620, FEBRA20132740, FEBRA20144170, FEHRT20003250, HCHON20007510, HLUNG20033780, IMR3220002430, KIDNE20008010, KIDNE20102710, KIDNE20107620, NT2NE20080170, NT2NE20181650, NT2RP70027380, NT2RP70036880, NT2RP70063950, NT2RP70078420, NT2RP70159960, NTONG20046140, NTONG20056570, OCBBF20028050, OCBBF20053430, OCBBF20054760, OCBBF20124360, OCBBF20127140, OCBBF20149280, OCBBF20173980, PEBLM20013120, PEBLM20085760, PROST20161950, PUAEN20015260, PUAEN20015860, PUAEN20083140, SMINT20028820, SMINT20049090, SMINT20110660, SPLEN20011410, SPLEN20121750, SPLEN20170310, SPLEN20181810, SPLEN20222270, SPLEN20250170, SPLEN20283650, TESTI20035960, TESTI20288910, TESTI20305540, TESTI20326810, TESTI20369650, TESTI20392250, TESTI20416640, TESTI20432750, TESTI20467320, THYMU20169680, THYMU20172150, THYMU20201980, THYMU20202890, TKIDN20004640, TKIDN20047480, TRACH20057690, UMVEN10001860, UTERU20146310
  • The clones predicted to belong to the category of transcription-related protein are the following 144 clones.
  • 3NB6920014590, ADIPS20004250, ASTRO20008010, ASTRO20168470, BLADE20003400, BLADE20003890, BRACE20060890, BRACE20068590, BRACE20257100, BRAMY20210400, BRAMY20260910, BRAMY20270730, BRAWH20028110, BRAWH20075700, BRAWH20096780, BRCAN20280210, BRCOC20144000, BRCOC20178270, BRHIP20005340, BRHIP20096170, BRHIP20119330, BRHIP20191860, BRHIP20195890, BRHIP20222280, BRSSN20039370, BRSSN20046790, BRSSN20176820, CTONG20050280, CTONG20075860, CTONG20085950, CTONG20091080, CTONG20092700, CTONG20121010, CTONG20124220, CTONG20133390, CTONG20133520, D9OST20033970, FCBBF10001710, FCBBF10004370, FCBBF20059090, FCBBF20068820, FCBBF30007680, FCBBF30010810, FCBBF30018550, FCBBF30025560, FCBBF30057290, FCBBF30083820, FCBBF30129630, FCBBF30240960, FCBBF30246230, FEBRA20018690, FEBRA20026110, FEBRA20034680, FEBRA20040530, FEBRA20082010, FEBRA20171380, FEBRA20195820, FEBRA20233770, HCHON20008320, HCHON20009560, HCHON20035130, HHDPC10000830, HHDPC20030490, HHDPC20031130, KIDNE20027250, KIDNE20027950, KIDNE20182690, LIVER20055440, NT2NE20010490, NT2NE20089970, NT2NE20142210, NT2NE20184900, NT2RP60000770, NT2RP70043480, NT2RP70063950, NT2RP70102350, NT2RP70157890, NTONG20070200, OCBBF10001850, OCBBF20020830, OCBBF20037440, OCBBF20046120, OCBBF20049300, OCBBF20054200, OCBBF20066390, OCBBF20071840, OCBBF20080410, OCBBF20108190, OCBBF20125530, OCBBF20148280, PEBLM20060360, PEBLM20078320, PERIC20003870, PROST10003220, PROST20047390, PROST20066880, PROST20185830, PROST20189770, PROST20191640, SKNSH20008190, SMINT20001760, SMINT20028820, SMINT20130320, SMINT20144800, SPLEN20026950, SPLEN20054290, SPLEN20079260, SPLEN20095410, SPLEN20117660, SPLEN20140800, SPLEN20147390, SPLEN20160450, SPLEN20162680, SPLEN20243830, SPLEN20250170, SPLEN20252190, SPLEN20267650, STOMA20032890, STOMA20063250, TESTI20039400, TESTI20041690, TESTI20067200, TESTI20088220, TESTI20130010, TESTI20156100, TESTI20230850, TESTI20318090, TESTI20320670, TESTI20378190, TESTI20385960, TESTI20409890, TESTI20420620, TESTI20432820, TESTI20456110, THYMU20247480, TRACH20079690, TRACH20154860, TRACH20163170, TRACH20164980, TRACH20184490, UTERU20099720, UTERU20116570, UTERU20145480, UTERU20176130
  • The clones predicted to belong to the category of disease-related protein are the following 387 clones.
  • ADIPS20004250, ADRGL10001470, ADRGL20011190, ADRGL20018300, ADRGL20035850, ADRGL20078100, ASTRO10001650, ASTRO20008010, ASTRO20027430, ASTRO20106150, ASTRO20108190, ASTRO20168470, BLADE20003400, BLADE20003890, BRACE20038480, BRACE20039540, BRACE20059370, BRACE20108130, BRACE20108880, BRACE20115920, BRACE20116460, BRACE20232840, BRACE20248260, BRACE20253330, BRACE20284100, BRALZ20013500, BRALZ20017430, BRALZ20018340, BRAMY20000520, BRAMY20025840, BRAMY20120910, BRAMY20134140, BRAMY20135900, BRAMY20162510, BRAMY20174550, BRAMY20210400, BRAMY20211390, BRAMY20242470, BRAMY20245300, BRAMY20266850, BRAMY20285160, BRAWH20016620, BRAWH20028110, BRAWH20064050, BRAWH20096780, BRAWH20110960, BRAWH20113430, BRAWH20114000, BRAWH20118230, BRAWH20121640, BRAWH20128270, BRAWH20137480, BRCAN20103740, BRCAN20224720, BRCAN20279700, BRCAN20280210, BRCAN20283190, BRCOC20001860, BRCOC20006370, BRCOC20027510, BRCOC20055420, BRCOC20099370, BRCOC20178270, BRCOC20178560, BRHIP20003120, BRHIP20005340, BRHIP20174040, BRHIP20176420, BRHIP20191490, BRHIP20191860, BRHIP20194940, BRHIP20195890, BRHIP20222280, BRHIP20249110, BRHIP20285930, BRHIP30004880, BRSSN20013420, BRSSN20038200, BRSSN20039370, BRSSN20046790, BRSSN20066110, BRSSN20101100, BRSSN20120810, BRSSN20187310, BRTHA20046290, CD34C30004240, COLON10001350, CTONG20004690, CTONG20052650, CTONG20099550, CTONG20124220, CTONG20125640, CTONG20128430, CTONG20131560, CTONG20133390, CTONG20153300, CTONG20153580, CTONG20158040, CTONG20159530, D6OST20003580, D9OST20023970, DFNES20001530, DFNES20037420, FCBBF10001210, FCBBF10001710, FCBBF10003770, FCBBF20059090, FCBBF20064520, FCBBF20068820, FCBBF30010810, FCBBF30024750, FCBBF30025560, FCBBF30039020, FCBBF30049550, FCBBF30057290, FCBBF30083620, FCBBF30129630, FCBBF30190850, FCBBF30238870, FCBBF30240960, FCBBF30243640, FCBBF30279030, FCBBF30281880, FCBBF40001730, FEBRA10001880, FEBRA20004620, FEBRA20010120, FEBRA20018690, FEBRA20082010, FEBRA20097310, FEBRA20130190, FEBRA20132740, FEBRA20144170, FEBRA20195820, FEBRA20223220, FEBRA20233770, FEBRA20235500, FEHRT20003250, HCHON10001760, HCHON20007380, HCHON20008320, HCHON20009560, HCHON20015230, HCHON20015980, HCHON20016040, HCHON20035130, HCHON20036420, HCHON20064590, HCHON20067700, HCHON20086720, HCHON20100740, HEART20003060, HEART20017730, HEART20025980, HEART20049410, HHDPC20014320, HHDPC20030490, HHDPC20084140, HHDPC20091140, HHDPC20091780, HHDPC20092080, HLUNG20033780, IMR3220002430, KIDNE20007770, KIDNE20020150, KIDNE20021680, KIDNE20022620, KIDNE20024830, KIDNE20027950, KIDNE20101370, KIDNE20101510, KIDNE20182690, LIVER20002160, LIVER20055200, LIVER20055440, LIVER20059810, LIVER20064690, MESAN20101140, MESAN20125860, MESAN20130220, MESAN20154010, MESAN20174170, NOVAR10000910, NT2NE20010490, NT2NE20118960, NT2NE20157470, NT2RI20040990, NT2RI20041880, NT2RI20048840, NT2RI20050960, NT2RI20240080, NT2RP60000770, NT2RP70027380, NT2RP70032610, NT2RP70037240, NT2RP70192730, NT2RP70198350, NTONG20013620, NTONG20015870, NTONG20028070, NTONG20067830, NTONG20070200, NTONG20090600, NTONG20092330, OCBBF20006770, OCBBF20037440, OCBBF20046120, OCBBF20049300, OCBBF20053490, OCBBF20053730, OCBBF20054760, OCBBF20071840, OCBBF20072240, OCBBF20078920, OCBBF20108430, OCBBF20108580, OCBBF20127140, OCBBF20129360, OCBBF20145760, OCBBF20153350, OCBBF20173980, OCBBF20178880, PEBLM10000710, PEBLM20013120, PERIC10000250, PLACE60060420, PLACE60177140, PROST20100460, PROST20159240, PROST20169800, PROST20176170, PUAEN20018820, PUAEN20030180, PUAEN20055020, PUAEN20083140, SKMUS20018230, SKMUS20018500, SKMUS20021530, SKMUS20024750, SKMUS20029200, SKMUS20048970, SKMUS20049030, SKNSH20008190, SKNSH20089400, SMINT20001760, SMINT20026890, SMINT20028820, SMINT20050750, SMINT20073650, SMINT20105330, SMINT20112730, SMINT20121220, SMINT20127350, SMINT20127930, SMINT20136130, SMINT20138900, SMINT20153260, SMINT20155180, SMINT20179740, SMINT20190170, SMINT20191420, SPLEN20006070, SPLEN20011410, SPLEN20026950, SPLEN20027440, SPLEN20039240, SPLEN20079260, SPLEN20095410, SPLEN20146450, SPLEN20147390, SPLEN20151210, SPLEN20160450, SPLEN20170310, SPLEN20179180, SPLEN20186430, SPLEN20212730, SPLEN20243830, SPLEN20245300, SPLEN20250390, SPLEN20252190, SPLEN20267650, SPLEN20305620, STOMA20001830, STOMA20005390, STOMA20008880, STOMA20010250, STOMA20034770, STOMA20046680, STOMA20056670, STOMA20064470, STOMA20077450, STOMA20080500, STOMA20083610, STOMA20088380, SYNOV20001520, SYNOV20001730, SYNOV2.0002790, SYNOV20002970, SYNOV20007000, SYNOV20008240, SYNOV20009230, SYNOV20010880, SYNOV20011110, TBAES20003770, TESOP20004000, TESOP20005270, TESTI20031270, TESTI20036380, TESTI20044310, TESTI20067200, TESTI20116830, TESTI20121550, TESTI20156100, TESTI20168480, TESTI20208400, TESTI20215990, TESTI20231940, TESTI20234360, TESTI20237520, TESTI20238610, TESTI20239510, TESTI20249990, TESTI20266740, TESTI20316870, TESTI20318090, TESTI20335050, TESTI20335200, TESTI20343570, TESTI20352620, TESTI20368330, TESTI20369650, TESTI20385960, TESTI20392250, TESTI20400940, TESTI20404240, TESTI20420620, TESTI20436560, TESTI20438570, TESTI20441940, TESTI20442760, TESTI20443090, TESTI20449200, TESTI20455090, TESTI20455620, TESTI20456110, TESTI20463580, TESTI20465350, TESTI20465690, TESTI20467210, THYMU20122730, THYMU20126900, THYMU20130890, THYMU20159430, THYMU20169680, THYMU20172150, THYMU20180280, THYMU20193640, THYMU20209590, THYMU20232090, THYMU20247480, TKIDN10000010, TKIDN20004640, TKIDN20047480, TRACH20016210, TRACH20019960, TRACH20050040, TRACH20057690, TRACH20067620, TRACH20077540, TRACH20079690, TRACH20096610, TRACH20105870, TRACH20121380, TRACH20154860, TRACH20162860, TRACH20163170, TRACH20164980, TRACH20190240, TSTOM20005690, TUTER20002830, UTERU20030570, UTERU20116570, UTERU20144640, UTERU20151980, UTERU20158800, UTERU20183640, UTERU20185230
  • In particular, hit data of the following 386 clones for Swiss-Prot, or GenBank, UniGene, or nr corresponded to genes or proteins which had been deposited in the Online Mendelian Inheritance in Man (OMIM), which is the human gene and disease database, (the OMIM Number is shown in the parenthesis after the Clone Name).
  • ADIPS20004250 (601505), ADRGL10001470 (202010;103900), ADRGL20011190 (182790), ADRGL20018300 (600025), ADRGL20035850 (202110), ADRGL20078100 (103270), ASTRO10001650 (126660), ASTRO20008010 (603899), ASTRO20027430 (179555), ASTRO20106150 (602537), ASTRO20108190 (191092), ASTRO20168470 (604077), BLADE20003400 (601276), BLADE20003890 (604077), BRACE20038480 (601504), BRACE20039540 (600169), BRACE20059370 (130500;266140), BRACE20108130 (605413), BRACE20108880 (603758), BRACE20115920 (300023),
  • BRACE20116460 (603150), BRACE20232840 (601213), BRACE20248260 (600813), BRACE20253330 (604990), BRACE20284100 (602415), BRALZ20013500 (602470), BRALZ20017430 (600658), BRALZ20018340 (600547), BRAMY20000520 (164020), BRAMY20025840 (602327), BRAMY20120910 (600188), BRAMY20134140 (603931), BRAMY20135900 (601342), BRAMY20162510 (300098), BRAMY20174550 (605464), BRAMY20210400 (603809), BRAMY20211390 (602212), BRAMY20242470 (605000), BRAMY20245300 (605367), BRAMY20266850 (605609), BRAMY20285160 (120700), BRAWH20016620 (605762), BRAWH20028110 (602330), BRAWH20064050 (135820), BRAWH20096780 (602277), BRAWH20110960 (603481), BRAWH20113430 (602649), BRAWH20114000 (138130), BRAWH20118230 (112267), BRAWH20121640 (604437), BRAWH20128270 (601997), BRAWH20137480 (602330), BRCAN20103740 (602566), BRCAN20224720 (600923;176200), BRCAN20279700 (604205), BRCAN20280210 (194538), BRCAN20283190 (602118), BRCOC20001860 (604346), BRCOC20006370 (603784), BRCOC20027510 (179555), BRCOC20055420 (603801), BRCOC20099370 (606045), BRCOC20178270 (194558), BRCOC20178560 (602567), BRHIP20003120 (604249), BRHIP20005340 (147586), BRHIP20174040 (602658), BRHIP20176420 (164020), BRHIP20191490 (600009), BRHIP20191860 (602272), BRHIP20194940 (604696), BRHIP20195890 (602211), BRHIP20222280 (603899), BRHIP20249110 (142600), BRHIP20285930 (602626), BRHIP30004880 (188840), BRSSN20013420 (300272), BRSSN20038200 (602306), BRSSN20039370 (194531), BRSSN20046790 (604077), BRSSN20066110 (605248), BRSSN20101100 (600188), BRSSN20120810 (142440), BRSSN20187310 (182900), BRTHA20046290 (602644), COLON10001350 (146900), CTONG20004690 (600019), CTONG20052650 (603871), CTONG20099550 (190370), CTONG20124220 (184756), CTONG20125640 (180510), CTONG20128430 (601797), CTONG20131560 (103390), CTONG20133390 (604077), CTONG20153300 (604334), CTONG20153580 (605652), CTONG20158040 (602862), CTONG20159530 (600395), D6OST20003580 (602443), D9OST20023970 (601525), DFNES20001530 (164500), DFNES20037420 (139259), FCBBF10001210 (602461), FCBBF10001710 (194558), FCBBF10003770 (604597), FCBBF20059090 (194542), FCBBF20064520 (164020), FCBBF20068820 (194558), FCBBF30010810 (603899), FCBBF30024750 (603706), FCBBF30025560 (600494), FCBBF30039020 (602835), FCBBF30049550 (106410), FCBBF30057290 (194556), FCBBF30083620 (300022), FCBBF30129630 (603899), FCBBF30190850 (131210), FCBBF30238870 (602320), FCBBF30240960 (604078), FCBBF30243640 (601961), FCBBF30279030 (605208), FCBBF30281880 (602517), FCBBF40001730 (176981), FEBRA10001880 (605451), FEBRA20004620 (600278), FEBRA20010120 (600368), FEBRA20018690 (194542), FEBRA20082010 (602187), FEBRA20097310 (602895), FEBRA20130190 (605863), FEBRA20132740 (602654), FEBRA20144170 (601685), FEBRA20195820 (604074), FEBRA20223220 (604633), FEBRA20233770 (603347), FEBRA20235500 (312090), FEHRT20003250 (600286), HCHON10001760 (605315), HCHON20007380 (600833), HCHON20008320 (604077), HCHON20009560 (194548), HCHON20015230 (604646), HCHON20015980 (604789), HCHON20016040 (146732), HCHON20035130 (194529), HCHON20036420 (603434), HCHON20064590 (103950), HCHON20067700 (603054), HCHON20086720 (146732), HCHON20100740 (602281), HEART20003060 (109480), HEART20017730 (106410), HEART20025980 (602127), HEART20049410 (603777), HHDPC20014320 (602714), HHDPC20030490 (603795), HHDPC20084140 (605184), HHDPC20091140 (603054), HHDPC20091780 (227400), HHDPC20092080 (146732), HLUNG20033780 (600888), IMR3220002430 (602923), KIDNE20007770 (114890), KIDNE20020150 (140550;603012), KIDNE20021680 (601609), KIDNE20022620 (603590), KIDNE20024830 (604205), KIDNE20027950 (194531), KIDNE20101370 (602580), KIDNE20101510 (191845), KIDNE20182690 (605226), LIVER20002160 (600816), LIVER20055200 (604814), LIVER20055440 (605277), LIVER20059810 (230350), LIVER20064690 (601841), MESAN20101140 (602567), MESAN20125860 (155750), MESAN20130220 (603778), MESAN20154010 (180480), MESAN20174170 (602516), NOVAR10000910 (159350), NT2NE20010490 (603899), NT2NE20118960 (180490), NT2NE20157470 (217000), NT2RI20040990 (106410), NT2RI20041880 (160775), NT2RI20048840 (139360), NT2RI20050960 (606103), NT2RI20240080 (603419), NT2RP60000770 (603044), NT2RP70027380 (118423), NT2RP70032610 (172430), NT2RP70037240 (604108), NT2RP70192730 (278000), NT2RP70198350 (300043), NTONG20013620 (604125), NTONG20015870 (123940), NTONG20028070 (602369), NTONG20067830 (182900), NTONG20070200 (194558), NTONG20090600 (313440), NTONG20092330 (153700), OCBBF20006770 (154500), OCBBF20037440 (602290), OCBBF20046120 (601262), OCBBF20049300 (602277), OCBBF20053490 (154550;602579), OCBBF20053730 (603604), OCBBF20054760 (603453), OCBBF20071840 (604077), OCBBF20072240 (604331), OCBBF20078920 (602120), OCBBF20108430 (139360), OCBBF20108580 (300103), OCBBF20127140 (139380), OCBBF20129360 (602142), OCBBF20145760 (600395), OCBBF20153350 (601935), OCBBF20173980 (603524), OCBBF20178880 (601617), PEBLM10000710 (601007), PEBLM20013120 (602288), PERIC10000250 (603582), PLACE60060420 (180469), PLACE60177140 (600022), PROST20100460 (158374), PROST20159240 (606019), PROST20169800 (604426), PROST20176170 (605903), PUAEN20018820 (164740), PUAEN20030180 (603263), PUAEN20055020 (604677), PUAEN20083140 (604762), SKMUS20018230 (603768), SKMUS20018500 (601402), SKMUS20021530 (606045), SKMUS20024750 (179555), SKMUS20029200 (605758), SKMUS20048970 (102610), SKMUS20049030 (161650), SKNSH20008190 (604075), SKNSH20089400 (603070), SMINT20001760 (194558), SMINT20026890 (602127), SMINT20028820 (604719), SMINT20050750 (182120), SMINT20073650 (146900), SMINT20105330 (230500;230600;230650;253010), SMINT20112730 (146900), SMINT20121220 (160776), SMINT20127350 (180740), SMINT20127930 (146900), SMINT20136130 (147220), SMINT20138900 (125660;601419), SMINT20153260 (602201), SMINT20155180 (603004), SMINT20179740 (147020), SMINT20190170 (146900), SMINT20191420 (102770),
  • SPLEN20006070 (182900), SPLEN20011410 (602732), SPLEN20026950 (600014), SPLEN20027440 (106410), SPLEN20039240 (140550;603012), SPLEN20079260 (604074), SPLEN20095410 (602277), SPLEN20146450 (602861), SPLEN20147390 (604078), SPLEN20151210 (600267), SPLEN20160450 (604375), SPLEN20170310 (605216), SPLEN20179180 (605890), SPLEN20186430 (600052), SPLEN20212730 (114230), SPLEN20243830 (601796), SPLEN20245300 (606004), SPLEN20250390 (114220), SPLEN20252190 (604077), SPLEN20267650 (602277), SPLEN20305620 (126064), STOMA20001830 (146900), STOMA20005390 (146900), STOMA20008880 (601652;137750), STOMA20010250 (605786), STOMA20034770 (146900), STOMA20046680 (164772), STOMA20056670 (146900), STOMA20064470 (173320), STOMA20077450 (314370), STOMA20080500 (605414), STOMA20083610 (146900), STOMA20088380 (146900), SYNOV20001520 (147200), SYNOV20001730 (147120), SYNOV20002790 (147120), SYNOV20002970 (147120), SYNOV20007000 (147120), SYNOV20008240 (147120), SYNOV20009230 (146900), SYNOV20010880 (147120), SYNOV20011110 (147120), TBAES20003770 (118990), TESOP20004000 (116810), TESOP20005270 (600641), TESTI20031270 (191161), TESTI20036380 (126650;214700), TESTI20044310 (179555), TESTI20067200 (176312), TESTI20116830 (603142), TESTI20121550 (600862), TESTI20156100 (602253), TESTI20168480 (188840), TESTI20208400 (164031), TESTI20215990 (605652), TESTI20231940 (604200), TESTI20234360 (601052), TESTI20237520 (604212), TESTI20238610 (300097), TESTI20239510 (604334),
  • TESTI20249990 (164500), TESTI20266740 (605198), TESTI20316870 (605497), TESTI20318090 (604077), TESTI20335050 (605209), TESTI20335200 (109770), TESTI20343570 (190470), TESTI20352620 (176801;249900), TESTI20368330 (157680), TESTI20369650 (602052), TESTI20385960 (605970), TESTI20392250 (605541), TESTI20400940 (117143), TESTI20404240 (602725), TESTI20420620 (602955), TESTI20436560 (150330), TESTI20438570 (603577), TESTI20441940 (604119), TESTI20442760 (603491), TESTI20443090 (602954), TESTI20449200 (604101),
  • TESTI20455090 (148070), TESTI20455620 (140560), TESTI20456110 (109092), TESTI20463580 (603486), TESTI20465350 (123830), TESTI20465690 (605468), TESTI20467210 (600833), THYMU20122730 (604700), THYMU20126900 (603370), THYMU20130890 (603675), THYMU20159430 (146900), THYMU20169680 (601441), THYMU20172150 (605000), THYMU20180280 (600549), THYMU20193640 (603083;164021), THYMU20209590 (602378), THYMU20232090 (601717), THYMU20247480 (604077), TKIDN10000010 (605034), TKIDN20004640 (137028), TKIDN20047480 (602399), TRACH20016210 (136836), TRACH20019960 (182310), TRACH20050040 (603784), TRACH20057690 (164731), TRACH20067620 (600429;110800), TRACH20077540 (300080), TRACH20079690 (604078), TRACH20096610 (150330), TRACH20105870 (600495), TRACH20121380 (602513), TRACH20154860 (180240), TRACH20162860 (603845), TRACH20163170 (601739), TRACH20164980 (602277), TRACH20190240 (604633), TSTOM20005690 (605775), TUTER20002830 (602719), UTERU20030570 (602023;241200), UTERU20116570 (602330),
  • UTERU20144640 (228000), UTERU20151980 (602038), UTERU20158800 (600738), UTERU20183640 (601281), UTERU20185230 (605333)
  • The clones predicted to belong to the category of enzyme and/or metabolism-related protein are the following 206 clones.
  • 3NB6910001910, ADRGL10001470, ADRGL20035850, ADRGL20078100, ASTRO20105820, ASTRO20106150, ASTRO20130500, ASTRO20145760, BRACE20027620, BRACE20038000, BRACE20062640, BRACE20096200, BRACE20107530, BRACE20108130, BRACE20108880, BRACE20116460, BRACE20148240, BRACE20185680, BRACE20253160, BRALZ20017430, BRALZ20018340, BRAMY20104640, BRAMY20134140, BRAMY20153110, BRAMY20213100, BRAMY20252720, BRAWH20016620, BRAWH20105840, BRAWH20112940, BRAWH20114000, BRAWH20117950, BRAWH20125380, BRAWH20132190, BRAWH20171030, BRCAN20054490, BRCAN20224720, BRCAN20280360, BRCAN20283190, BRCAN20283380, BRCOC20001860, BRCOC20031250, BRCOC20055420, BRCOC20091960, BRCOC20144000, BRHIP10001290, BRHIP20005530, BRHIP20096850, BRHIP20103090, BRHIP20174040, BRHIP20249110, BRSSN20013420, BRSSN20015790, BRSSN20120810, BRSSN20146100, CTONG20095340, CTONG20106520, CTONG20118250, CTONG20127450, CTONG20140580, CTONG20153300, CTONG20158040, D3OST20006180, D6OST20003580, DFNES20031920, DFNES20071130, FCBBF10001820, FCBBF10003670, FCBBF30012350, FCBBF30012810, FCBBF30175310, FCBBF30243640, FEBRA10001880, FEBRA20007620, FEBRA20130190, FEBRA20144170, FEBRA20167390, FEBRA20196630, FEHRT20003250, HCHON10001760, HCHON20003220, HCHON20015350, HEART20034320, HEART20090000, HHDPC20014320, KIDNE20002520, KIDNE20008010, KIDNE20021680, KIDNE20022620, KIDNE20028390, KIDNE20028720, KIDNE20107620, LIVER20059810, MESAN20154010, NT2NE20118960, NT2NE20157470, NT2RI20005750, NT2RI20244600, NT2RI20273230, NT2RP70032610, NT2RP70045590, NT2RP70192730, NT2RP70195430, NTONG20009770, NTONG20013620, NTONG20046140, OCBBF20028650, OCBBF20030910, OCBBF20046690, OCBBF20050770, OCBBF20053430, OCBBF20053490, OCBBF20053730, OCBBF20054760, OCBBF20078920, OCBBF20124360, OCBBF20129360, OCBBF20178880, PEBLM20044520, PEBLM20052820, PEBLM20060490, PERIC10000250, PLACE50000660, PROST20083600, PROST20169800, PUAEN20015260, PUAEN20030180, SKMUS20018230, SMINT20028820, SMINT20049090, SMINT20102780, SMINT20105330, SMINT20106290, SMINT20110660, SMINT20152940, SMINT20191420, SMINT20191530, SPLEN20021660, SPLEN20026950, SPLEN20121750, SPLEN20145720, SPLEN20149240, SPLEN20150940, SPLEN20151210, SPLEN20173510, SPLEN20212730, SPLEN20250390, SPLEN20305620, STOMA20006860, STOMA20077450, TBAES20002550, TBAES20003150, TESOP20004000, TESOP20005270, TESTI20001000, TESTI20002720, TESTI20002780, TESTI20060400, TESTI20066670, TESTI20082330, TESTI20083200, TESTI20108720, TESTI20116830, TESTI20143390, TESTI20148000, TESTI20216370, TESTI20232140, TESTI20234360, TESTI20237520, TESTI20239510, TESTI20266740, TESTI20314180, TESTI20334410, TESTI20343570, TESTI20352620, TESTI20355020, TESTI20366910, TESTI20368330, TESTI20369650, TESTI20375340, TESTI20397760, TESTI20416640, TESTI20432750, TESTI20463580, TESTI20465350, TESTI20471410, TESTI20473830, THYMU20023380, THYMU20111830, THYMU20126900, THYMU20169680, THYMU20202890, TKIDN20004640, TKIDN20047480, TRACH20003590, TRACH20016210, TRACH20019960, TRACH20041830, TRACH20057690, TRACH20067620, TRACH20084720, TRACH20085830, TRACH20162860, UTERU20064860, UTERU20144640, UTERU20146310, UTERU20151980
  • The clones predicted to belong to the category of cytoskeleton-related protein are the following 75 clones.
  • ADRGL20011190, ADRGL20018300, ASTRO10001650, ASTRO20055750, BRACE20003070, BRACE20059370, BRACE20163350, BRAMY20121620, BRAMY20157820, BRAMY20242470, BRAWH20028110, BRAWH20137480, BRCAN20003460, BRCOC20008160, BRCOC20059510, BRHIP20115080, BRHIP20137230, BRHIP20167880, BRHIP20283030, BRHIP20285830, BRSSN20187310, CTONG10002770, CTONG20052900, CTONG20121580, FCBBF10001150, FCBBF30013770, FCBBF30015940, FCBBF30049550, FEBRA20024100, FEBRA20237640, HCHON20015980, HCHON20068410, HEART20017730, HEART20025980, HEART20061950, HEART20077670, HLUNG20016330, KIDNE20118580, MESAN20004570, NT2RI20040990, NT2RI20041880, NT2RP70037240, NT2RP70062230, NTONG20015870, NTONG20056570, NTONG20067830, NTONG20090600, OCBBF20107090, OCBBF20155060, PLACE60079250, PUAEN20040670, SKMUS20001980, SKMUS20016220, SKMUS20048970, SKMUS20049030, SMINT20024570, SMINT20026890, SMINT20121220, SMINT20138900, SPLEN20006070, SPLEN20027440, SPLEN20142100, TESTI20063830, TESTI20094230, TESTI20278400, TESTI20371030, TESTI20417300, TESTI20436560, TESTI20455090, THYMU20105190, THYMU20172150, THYMU20209590, TRACH20096610, UMVEN10001560, UTERU20116570
  • The clones predicted to belong to the category of nuclear protein and/or RNA synthesis-related protein are the following 65 clones.
  • BRACE20057190, BRACE20064880, BRACE20248260, BRACE20253160, BRAMY20000520, BRAMY20120910, BRAWH20113430, BRAWH20171030, BRCAN10001490, BRCAN20283190, BRCOC20037320, BRCOC20178560, BRHIP20106100, BRHIP20176420, BRHIP20243470, BRSSN20101100, CTONG20114290, CTONG20125540, CTONG20131560, CTONG20140580, DFNES20001530, FCBBF20064520, FEBRA20007620, FEBRA20010120, FEBRA20097310, FEBRA20144170, FEBRA20174410, FEBRA20215500, IMR3220002430, MESAN20101140, NT2RI20273230, OCBBF20028650, OCBBF20030910, OCBBF20078920, PROST20104000, PUAEN20018820, SKMUS20007010, SMINT20127350, SMINT20177360, SMINT20191530, SPLEN20008740, SPLEN20146450, STOMA20046680, TESTI20082330, TESTI20094470, TESTI20121550, TESTI20208400, TESTI20234360, TESTI20237520, TESTI20249990, TESTI20334410, TESTI20355020, TESTI20368330, TESTI20392760, TESTI20408970, TESTI20436560, TESTI20438570, TESTI20443090, THYMU20193640, THYMU20202890, THYMU20241210, TRACH20096610, TUTER20002830, UTERU20151980, UTERU20176320
  • The clones predicted to belong to the category of protein synthesis and/or transport-related protein are the following 62 clones.
  • 3NB6910001910, ASTRO20106150, ASTRO20130500, ASTRO20141350, BRACE20038480, BRACE20052160, BRACE20057620, BRACE20106840, BRACE20172980, BRACE20192440, BRAWH20110960, BRCOC20037320, BRHIP20005530, BRSSN20120810, BRSTN20005360, CTONG20009770, CTONG20114290, CTONG20125640, CTONG20153300, D6OST20003580, DFNES20037420, FCBBF30012810, FEBRA20080810, HCHON20064590, HHDPC20014320, HHDPC20084140, HLUNG20017120, LIVER20064690, NT2NE20132170, NT2NE20157470, NT2RP70133740, NTONG20009770, NTONG20075220, NTONG20076930, OCBBF20030910, OCBBF20035930, OCBBF20153340, PLACE60060420, SMINT20152940, SPLEN20008740, SPLEN20103950, SPLEN20118300, SPLEN20212730, SPLEN20250390, STOMA20077450, TBAES20002550, TESOP20004000, TESTI20239510, TESTI20278400, TESTI20314180, TESTI20463580, THYMU20111830, THYMU20122730, THYMU20130890, THYMU20232090, TKIDN10000010, TRACH20084720, TRACH20105870, TRACH20139820, TRACH20149970, UTERU20120310, UTERU20188110
  • The clones predicted to belong to the category of cellular defense-related protein are the following 15 clones.
  • BRCOC20144000, CTONG20092680, KIDNE20020150, LIVER20002160, NT2RI20050960, NT2RP70045590, OCBBF20128120, PLACE60003480, SKNSH20089400, SMINT20106290, SPLEN20039240, TESTI20001000, TESTI20455620, TRACH20028030, UTERU20176320
  • The clones predicted to belong to the category of development and/or differentiation-related protein are the following 13 clones.
  • 3NB6920014590, BRAMY20211390, CTONG20091080, CTONG20121010, FCBBF30024750, KIDNE20027250, NT2NE20142210, OCBBF20054200, PROST10003220, SKMUS20007010, SPLEN20179810, STOMA20063250, TESTI20291960
  • The clones predicted to belong to the category of DNA-binding and/or RNA-binding protein are the following 174 clones.
  • 3NB6920014590, ADIPS20004250, ASTRO20008010, ASTRO20168470, BLADE20003400, BLADE20003890, BRACE20057620, BRACE20060890, BRACE20064880, BRACE20068590, BRACE20248260, BRACE20253160, BRAMY20000520, BRAMY20213100, BRAMY20260910, BRAMY20270730, BRAWH20028110, BRAWH20075700, BRAWH20096780, BRAWH20113430, BRCAN10001490, BRCAN20280210, BRCAN20283190, BRCOC20144000, BRCOC20178270, BRCOC20178560, BRHIP20005340, BRHIP20106100, BRHIP20119330, BRHIP20153600, BRHIP20176420, BRHIP20191860, BRHIP20195890, BRHIP20222280, BRSSN20039370, BRSSN20046790, BRSSN20176820, CTONG20050280, CTONG20075860, CTONG20085950, CTONG20091080, CTONG20092700, CTONG20121010, CTONG20124220, CTONG20125540, CTONG20133390, CTONG20133520, CTONG20140580, CTONG20156780, D9OST20033970, FCBBF10001710, FCBBF10004370, FCBBF20059090, FCBBF20064520, FCBBF20068820, FCBBF30007680, FCBBF30010810, FCBBF30018550, FCBBF30025560, FCBBF30057290, FCBBF30083820, FCBBF30129630, FCBBF30240960, FCBBF30246230, FEBRA20010120, FEBRA20018690, FEBRA20026110, FEBRA20034680, FEBRA20040530, FEBRA20082010, FEBRA20097310, FEBRA20171380, FEBRA20195820, FEBRA20196630, FEBRA20233770, HCHON20008320, HCHON20009560, HCHON20035130, HHDPC10000830, HHDPC20031130, KIDNE20017130, KIDNE20027250, KIDNE20027950, KIDNE20107390, KIDNE20182690, LIVER20055440, MESAN20101140, NT2NE20010490, NT2NE20089970, NT2NE20142210, NT2NE20184900, NT2RP60000770, NT2RP70044280, NT2RP70102350, NT2RP70157890, NTONG20070200, OCBBF10001850, OCBBF20020830, OCBBF20037440, OCBBF20046120, OCBBF20049300, OCBBF20066390, OCBBF20071840, OCBBF20078920, OCBBF20080410, OCBBF20108190, OCBBF20125530, OCBBF20148280, PEBLM20060360, PEBLM20060490, PEBLM20078320, PERIC10000250, PROST10003220, PROST20047390, PROST20066880, PROST20185830, PROST20189770, PROST20191640, PUAEN20018820, SKNSH20008190, SKNSH20089400, SMINT20001760, SMINT20127350, SMINT20144800, SMINT20177360, SMINT20191530, SPLEN20054290, SPLEN20079260, SPLEN20095410, SPLEN20140800, SPLEN20147390, SPLEN20160450, SPLEN20252190, SPLEN20267650, STOMA20010250, STOMA20032890, STOMA20046680, STOMA20063250, TESTI20039400, TESTI20067200, TESTI20088220, TESTI20094470, TESTI20121550, TESTI20130010, TESTI20156100, TESTI20204450, TESTI20230850, TESTI20237520, TESTI20266740, TESTI20318090, TESTI20320670, TESTI20334410, TESTI20355020, TESTI20378190, TESTI20385960, TESTI20432820, TESTI20443090, TESTI20456110, THYMU20193640, THYMU20241210, THYMU20247480, TRACH20079690, TRACH20105870, TRACH20139820, TRACH20154860, TRACH20163170, TRACH20164980, TRACH20184490, TUTER20002830, UTERU20099720, UTERU20116570, UTERU20145480, UTERU20176130, UTERU20185230
  • The clones predicted to belong to the category of ATP binding and/or GTP-binding protein are the following 68 clones.
  • 3NB6910001910, BRACE20108130, BRACE20148240, BRAMY20134140, BRAMY20157820, BRAMY20174550, BRAWH20164460, BRCAN20003460, BRCAN20054490, BRCAN20283190, BRCOC20059510, BRCOC20144000, BRHIP20103090, BRHIP20115080, BRHIP20167880, BRSTN20005360, CD34C30004240, CTONG20095340, CTONG20121580, CTONG20200310, DFNES20037420, FCBBF20067810, FCBBF30012350, FCBBF30015940, FEBRA20007620, FEBRA20024100, FEBRA20144170, KIDNE20020150, KIDNE20028720, LIVER20002160, LIVER20087060, NT2RI20005750, NT2RI20041880, NT2RI20048840, NT2RI20273230, OCBBF20028650, OCBBF20046690, OCBBF20054760, OCBBF20108430, OCBBF20108630, SMINT20121220, SMINT20183530, SMINT20191530, SPLEN20026950, SPLEN20039240, SPLEN20099700, SPLEN20145720, SPLEN20179180, STOMA20006860, TESTI20035960, TESTI20355020, TESTI20397760, TESTI20400940, TESTI20417300, TESTI20443090, TESTI20455620, THYMU20105190, THYMU20202890, THYMU20209590, TKIDN20004640, TKIDN20047480, TRACH20005400, TRACH20019960, TRACH20057690, TRACH20084720, UTERU20168220, UTERU20176320, UTERU20185230
  • Among the clones other than the ones shown above, BRAMY20248490, FCBBF10002800, NTONG20092290, OCBBF20127040, SMINT20163960, THYMU20279750, TRACH20167220, are clones which were predicted to highly possibly belong to the category of secretory protein and/or membrane protein based on the result of domain search by Pfam.
  • FCBBF10002800, NTONG20092290, OCBBF20127040, SMINT20163960, TESTI20478850, THYMU20279750
  • The 6 clones shown above are clones which were predicted to highly possibly belong to the category of glycoprotein-related protein based on the result of domain search by Pfam.
  • BRACE20060720, BRACE20223330, BRALZ20058880, BRAMY20148130, BRAWH20101360, BRCAN20124080, BRHIP20253660, CTONG10000620, CTONG20014280, CTONG20124010, KIDNE20109890, MESAN20171520, OCBBF20109310, OCBBF20140640, PROST20079500, PUAEN20078980, SPLEN20077500, SPLEN20143180, TESTI20017950, TESTI20184620,
  • TESTI20208710, TESTI20211160, TESTI20226230, TESTI20234140, TESTI20258460, TESTI20275030
  • The 26 clones shown above are clones which were predicted to highly possibly belong to the category of signal transduction-related protein based on the result of domain search by Pfam.
  • ADRGL20048330, ASTRO20064750, ASTRO20084250, BRACE20151320, BRALZ20058880, BRHIP20207990, CTONG20093950, FCBBF30195640, FEBRA10001900, FEBRA20090290, FEBRA20214970, FEBRA20222040, KIDNE20109890, LIVER20087510, MESAN20029400, MESAN20031900, MESAN20035290, MESAN20136110, NT2NE20130190, PEBLM20060310, PERIC20004780, PROST20171280, PUAEN20078980, SMINT20115880, SPLEN20095550, TESTI20023510, TESTI20083940, TESTI20152460, TESTI20185650, TESTI20189410, TESTI20200710, TESTI20308600, TESTI20343070, TESTI20369690, TESTI20381040, UTERU20050690
  • The 36 clones shown above are clones which were predicted to highly possibly belong to the category of transcription-related protein based on the result of domain search by Pfam.
  • BGGI120006160, BRACE20053480, BRACE20190040, BRACE20223330, BRAWH20101360, BRAWH20185060, BRCOC20023230, BRHIP20252450, BRSSN20105870, BRSSN20117990, BRTHA20000570, CTONG20098440, CTONG20129960, CTONG20146300, CTONG20155180, FEBRA20025270, HEART20083640, KIDNE20009470, LIVER20035680, MESAN20029400, MESAN20031900, MESAN20186700, NOVAR10000150, NTONG20029480, OCBBF20079310, OCBBF20082830, PEBLM20042900, PLACE60136500, PLACE60136720, PROST20114390, SKNSH20020540, SMINT20013480, SMINT20174360, SPLEN20077500, SPLEN20119810, SPLEN20126190, SPLEN20174260, SPLEN20211220, TESTI20046750, TESTI20057750, TESTI20061110, TESTI20197940, TESTI20211160, TESTI20226230, TESTI20255820, TESTI20317600, TESTI20377230, THYMU20111180, THYMU20115850, THYMU20143270, THYMU20240710, UTERU20055330, UTERU20055930, UTERU20064000, UTERU20119060
  • The 55 clones shown above are clones which were predicted to highly possibly belong to the category of enzyme and/or metabolism-related protein based on the result of domain search by Pfam.
  • TESTI20127760, TESTI20392270
  • The 2 clones shown above are clones which were predicted to highly possibly belong to the category of cell division and/or cell proliferation-related protein based on the result of domain search by Pfam.
  • FCBBF30262510, MESAN20031900, NT2NE20125050, SMINT20068010, SPLEN20163560, STOMA20092890, TESTI20382750
  • The 7 clones shown above are clones which were predicted to highly possibly belong to the category of cytoskeleton-related protein based on the result of domain search by Pfam.
  • THYMU20118520
  • The clone shown above is clone which were predicted to highly possibly belong to the category of nuclear protein and/or RNA synthesis-related protein based on the result of domain search by Pfam.
  • BRACE20053480, BRACE20240740, KIDNE20009470, OCBBF20140890, SMINT20035690, UTERU20064000
  • The 6 clones shown above are clones which were predicted to highly possibly belong to the category of protein synthesis and/or transport-related protein based on the result of domain search by Pfam.
  • ADRGL20048330, ASTRO20064750, ASTRO20084250, BRACE20151320, BRACE20190040, BRACE20223330, BRALZ20058880, BRAMY20103570, BRCOC20023230, BRHIP20207990, BRTHA20000570, CTONG20093950, CTONG20129960, CTONG20146300, CTONG20155180, CTONG20160560, FCBBF10004120, FCBBF30195640, FEBRA10001900, FEBRA20090290, FEBRA20214970, FEBRA20222040, HCHON20008150, HEART20083640, KIDNE20109890, LIVER20035680, LIVER20087510, MESAN20029400, MESAN20031900, MESAN20035290, MESAN20136110, MESAN20186700, NT2NE20130190, NT2RI20025640, NTONG20029480, PEBLM20060310, PERIC20004780, PROST20114390, PROST20171280, PUAEN20078980, SMINT20115880, SPLEN20095550, SPLEN20119810, TESTI20023510, TESTI20057750, TESTI20083940, TESTI20152460, TESTI20185650, TESTI20189410, TESTI20200710, TESTI20308600, TESTI20343070, TESTI20369690, TESTI20381040, THYMU20115850, UTERU20050690, UTERU20055330
  • The 57 clones shown above are clones which were predicted to highly possibly belong to the category of DNA-binding and/or RNA-binding protein based on the result of domain search by Pfam.
  • PLACE60136720
  • The clone shown above is a clone which was predicted to highly possibly belong to the category of ATP-binding and/or GTP-binding protein based on the result of domain search by Pfam.
  • The 213 clones shown below are clones which were unassignable to any of the above-mentioned categories, but have been predicted to have some functions based on homology search for their full-length nucleotide sequences and motif search in their deduced ORFs. Clone Name, Definition in the result of homology search or Motif Name in the motif search, demarcated by a double slash mark (//), are shown below.
  • ADRGL20028570//Rattus norvegicus MG87 mRNA, complete cds.
  • ADRGL20061930//transposon-derived Buster1 transposase-like protein
  • ASTRO20012490//Eukaryotic initiation factor 1A
  • ASTRO20072210//PERIAXIN.
  • ASTRO20114370//Mus musculus SMAR1 mRNA, complete cds.
  • ASTRO20125520//dnaj protein [Schizosaccharomyces pombe]
  • ASTRO20143630//KH domain// Bacterial regulatory proteins, crp family
  • ASTRO20155290//TPR Domain// TPR Domain// TPR Domain
  • ASTRO20181690//oocyte-specific protein P100
  • BGGI110001930//UBX domain
  • BRACE20011070//Mus musculus F-box protein FBX15 mRNA, partial cds.
  • BRACE20039440//Drosophila melanogaster CHARYBDE (charybde) mRNA, complete cds.
  • BRACE20050900//TPR Domain// TPR Domain// TPR Domain// TPR Domain
  • BRACE20053280//Mus musculus Pdz-containing protein (Pdzx) mRNA, complete cds.
  • BRACE20057730//toxin sensitivity protein KTI12 homolog
  • BRACE20058580//Homo sapiens HCMOGT-1 mRNA for sperm antigen, complete cds.
  • BRACE20063780//NOL1/NOP2/sun family
  • BRACE20269200//Heat-labile enterotoxin alpha chain
  • BRACE20276430//Homo sapiens retinoblastoma-associated protein RAP140 mRNA, complete cds.
  • BRACE20286360//Alpha adaptin carboxyl-terminal domain
  • BRAMY10001300//Homo sapiens MAGE-E1b mRNA, complete cds.
  • BRAMY20045240//Flagellar L-ring protein
  • BRAMY20054880//Rattus norvegicus KPL2 (Kpl2) mRNA, complete cds.
  • BRAMY20167060//Collagen triple helix repeat (20 copies)
  • BRAMY20184670//Homo sapiens mRNA for ALEX1, complete cds.
  • BRAMY20217460//Homo sapiens cardiac voltage gated potassium channel modulatory subunit mRNA, complete cds, alternatively spliced.
  • BRAMY20240040//Homo sapiens suppressor of white apricot homolog 2 (SWAP2) mRNA, complete cds.
  • BRAMY20247110//Mus musculus semaphorin cytoplasmic domain-associated protein 3A (Semcap3) mRNA, complete cds.
  • BRAWH20004600//Mus musculus mRNA for NAKAP95, complete cds.
  • BRAWH20011710//cytoplasmic linker 2
  • BRAWH20012390//Trichomonas vaginalis mRNA for centrin (ce1 gene).
  • BRAWH20017010//Homo sapiens testes development-related NYD-SP22 mRNA, complete cds.
  • BRAWH20029630//Homo sapiens bet3 (BET3) mRNA, complete cds.
  • BRAWH20138660//Homo sapiens stonin 2 mRNA, complete cds.
  • BRCOC20008500//Human ras inhibitor mRNA, 3′ end.
  • BRCOC20026640//Gag P30 core shell protein
  • BRCOC20035130//14-3-3 PROTEIN EPSILON (MITOCHONDRIAL IMPORT STIMULATION FACTOR L SUBUNIT) (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) (14-3-3E).
  • BRCOC20074760//CDC4-LIKE PROTEIN (FRAGMENT).
  • BRCOC20110100//Integrase core domain
  • BRCOC20176520//Rattus norvegicus mRNA for type II brain 4.1, complete cds.
  • BRHIP20001630//Protein of unknown function DUF16
  • BRHIP20132860//Homo sapiens rhophilin-like protein mRNA, complete cds.
  • BRHIP20143730//MYND finger
  • BRHIP20175420//Mus musculus partial mRNA for stretch responsive protein 278 (sr278 gene).
  • BRHIP20236950//Outer Capsid protein VP4 (Hemagglutinin)
  • BRSSN20014260//RIBONUCLEASE INHIBITOR.
  • BRSSN20018690//Homo sapiens NY-REN-25 antigen mRNA, partial cds.
  • BRSSN20021600//RING CANAL PROTEIN (KELCH PROTEIN).
  • BRSSN20177570//Phosducin
  • BRSTN10000830//Kelch motif// Kelch motif// Kelch motif// Kelch motif
  • CTONG10000220//Mus musculus cerebellar postnatal development protein-1 (Cpd1) mRNA, partial cds.
  • CTONG10000930//Armadillo/beta-catenin-like repeats
  • CTONG20027090//Glypican// Leucine Rich Repeat// Leucine Rich Repeat
  • CTONG20076130//ZINC FINGER PROTEIN 185 (LIM-DOMAIN PROTEIN ZNF185) (P1-A).
  • CTONG20096750//Disintegrin
  • CTONG20100240//Mus musculus radial spokehead-L protein (Rshl1) mRNA, complete cds.
  • CTONG20139860//Homo sapiens nasopharyngeal carcinoma susceptibility protein LZ16 mRNA, complete cds.
  • CTONG20143690//MYND finger
  • CTONG20149460//RING CANAL PROTEIN (KELCH PROTEIN).
  • CTONG20165050//Keratin, high sulfur B2 protein
  • CTONG20186320//RING CANAL PROTEIN (KELCH PROTEIN).
  • D3OST20013280//ARP2/3 COMPLEX 16 KDA SUBUNIT (P16-ARC).
  • D3OST20024360//Homo sapiens neuroendocrine differentiation factor mRNA, complete cds.
  • D9OST20031370//Homo sapiens mRNA for partial putative TCPTP-interacting protein (ptpip5 gene).
  • DFNES20014040//TRICHOHYALIN.
  • FCBBF10000630//Homo sapiens huntingtin interacting protein HYPB mRNA, partial cds.
  • FCBBF10000770//Homo sapiens REC8 mRNA, partial cds.
  • FCBBF10005060//CELLULAR RETINALDEHYDE-BINDING PROTEIN (CRALBP).
  • FCBBF10005500//Keratin, high sulfur B2 protein
  • FCBBF20014270//ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR) (DBI) (ENDOZEPINE) (EP).
  • FCBBF20042170//Homo sapiens NIBAN mRNA, complete cds.
  • FCBBF30016320//SecA protein, amino terminal region
  • FCBBF30033050//Sm protein
  • FCBBF30054440//PLAT/LH2 domain
  • FCBBF30225660//Ank repeat// Ank repeat// Ank repeat// K+ channel tetramerisation domain// BTB/POZ domain
  • FCBBF30233680//G10 protein
  • FCBBF30246630//H. sapiens mRNA for ZYG homologue.
  • FCBBF30250730//TRICHOHYALIN.
  • FCBBF30252520//Homo sapiens bicaudal-D (BICD) mRNA, alternatively spliced, partial cds.
  • FCBBF30252800//NDRG1 PROTEIN (DIFFERENTIATION-RELATED GENE 1 PROTEIN) (DRG1) (REDUCING AGENTS AND TUNICAMYCIN-RESPONSIVE PROTEIN) (RTP) (NICKEL-SPECIFIC INDUCTION PROTEIN CAP43).
  • FCBBF30252850//Mus musculus peripherial benzodiazepine receptor associated protein (Pap7) mRNA, complete cds.
  • FCBBF30285280//Keratin, high sulfur B2 protein// Bacterial regulatory proteins, gntR family
  • FEBRA20088360//ALPHA-ADAPTIN C (CLATHRIN ASSEMBLY PROTEIN COMPLEX 2 ALPHA-C LARGE CHAIN) (100 KDA COATED VESICLE PROTEIN C) (PLASMA MEMBRANE ADAPTOR HA2/AP2 ADAPTIN ALPHA C SUBUNIT).
  • FEBRA20184330//Rattus norvegicus glutamate receptor interacting protein 2 (GRIP2) mRNA, complete cds.
  • FEBRA20192420//Cyclin-dependent kinase inhibitor// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif
  • FEBRA20196370//Cyclin-dependent kinase inhibitor// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif// IQ calmodulin-binding motif
  • FEBRA20225040//high-glucose-regulated protein 8
  • HCHON20001560//TRANSCRIPTION FACTOR-LIKE PROTEIN MORF4.
  • HCHON20003440//Homo sapiens cyclin-D binding Myb-like protein mRNA, complete cds.
  • HCHON20010990//TPR Domain
  • HCHON20059870//Hypothetical protein.
  • HHDPC20034390//Cereal trypsin/alpha-amylase inhibito
  • HHDPC20057420//Mus musculus proline-rich protein (Bprp) mRNA, complete cds.
  • HHDPC20064600//SUPPRESSOR PROTEIN SRP40.
  • HLUNG20023340//Mus musculus SLM-1 (Slm1) mRNA, complete cds.
  • KIDNE20007210//Xenopus laevis mRNA for RPA interacting protein alpha (ripalpha gene).
  • KIDNE20028830//K-box region
  • KIDNE20115080//Homo sapiens mRNA for hNBL4, complete cds.
  • KIDNE20124400//Homo sapiens mRNA for ALEX1, complete cds.
  • KIDNE20127100//Drosophila melanogaster Diablo (dbo) mRNA, complete cds.
  • KIDNE20127750//Homo sapiens partial mRNA for transport-secretion protein 2.1 (TTS-2.1 gene).
  • KIDNE20190740//Rattus norvegicus SNIP-b mRNA, complete cds.
  • LIVER10004790//EF hand
  • LIVER20011130//Homo sapiens F-box protein FBL9 mRNA, partial cds.
  • LIVER20064100//Ciona intestinalis mRNA for myoplasmin-C1, complete cds.
  • LIVER20080530//Drosophila melanogaster forked mRNA for large Forked protein, complete cds.
  • MAMGL10000830//Drosophila melanogaster L82B (L82) mRNA, complete cds.
  • MESAN20036460//Corticotropin-releasing factor family
  • MESAN20127350//myelin expression factor-3
  • MESAN20141920//Human ovarian cancer downregulated myosin heavy chain homolog (Doc1) mRNA, complete cds.
  • NT2NE20010400//Homo sapiens GLO13 mRNA, complete cds.
  • NT2NE20122430//GLYOXYLATE-INDUCED PROTEIN.
  • NT2NE20158600//erythroid ankyrin—Synechocystis sp. (strain PCC 6803).
  • NT2RI20001330//Homo sapiens KE03 protein mRNA, partial cds.
  • NT2RI20009870//lunatic fringe precursor [Mus musculus]
  • NT2RI20046080//recA bacterial DNA recombination proteins
  • NT2RI20091730//Molluscan rhodopsin C-terminal tail
  • NT2RP60000850//Bos taurus RPGR-interacting protein-1 (RPGRIP1) mRNA, complete cds.
  • NT2RP70080850//SPRY domain// Adenovirus EB1 55K protein/large t-an
  • NT2RP70105210//Myc amino-terminal region
  • NT2RP70188710//Yeast PIR proteins
  • NT2RP70194450//Bacterial regulatory proteins, crp family
  • NTONG20052650//Gallus gallus Xin mRNA, complete cds.
  • NTONG20064400//REPETIN.
  • NTONG20064840//Mus musculus slp1 mRNA for synaptotagmin-like protein 1, complete cds.
  • NTONG20066460//Mus musculus Gd mRNA for gasdermin, complete cds.
  • NTONG20067090//Mus musculus mRNA for Sh3yl1, complete cds.
  • NTONG20070340//collagen alpha 1(IX) chain
  • NTONG20083650//TPR Domain// TPR Domain// TPR Domain// PPR repeat// TPR Domain// PPR repeat// TPR Domain
  • NTONG20088620//Homo sapiens genethonin 3 mRNA, partial cds.
  • OCBBF10000540//Mus musculus ris (rjs) mRNA, complete cds.
  • OCBBF20019380//seizure related gene 6
  • OCBBF20022900//Homo sapiens SCHIP-1 mRNA, complete cds.
  • OCBBF20030280//Rattus norvegicus hfb2 mRNA, complete cds.
  • OCBBF20046470//ARFAPTIN 1.
  • OCBBF20049840//Homo sapiens mRNA for neurabin II protein.
  • OCBBF20068490//Mus musculus RW1 protein mRNA, complete cds.
  • OCBBF20071960//Coturnix coturnix japonica qMEF2D gene.
  • OCBBF20073540//Homo sapiens p30 DBC mRNA, complete cds.
  • OCBBF20121390//RING CANAL PROTEIN (KELCH PROTEIN).
  • OCBBF20127550//Outer Capsid protein VP4 (Hemagglutinin)
  • OCBBF20148730//RING CANAL PROTEIN (KELCH PROTEIN).
  • OCBBF20178150//Plasmodium falciparum ADA2-like protein gene, partial cds.
  • PEBLM10000240//Domain found in Dishevelled, Eg1-10, and Ple PROST20047270//CRAL/TR10 domain.
  • PROST20112970//Sterile alpha motif (SAM)/Pointed domain// SAM domain (Sterile alpha motif)
  • PUAEN10000850//Uncharacterized protein family UPF0025//Sec1 family
  • PUAEN20011880//Mus musculus mRNA for MIWI (piwi), complete cds.
  • PUAEN20051100//Mus musculus otogelin mRNA, complete cds.
  • PUAEN20108240//Drosophila melanogaster ankyrin 2 (Ank2) mRNA, complete cds.
  • SKMUS20084740//Syndecan domain
  • SMINT20053300//Homo sapiens hepatocellular carcinoma-associated antigen 59 mRNA, complete cds.
  • SMINT20071400//NOL1/NOP2/sun family
  • SMINT20101440//Human cisplatin resistance associated alpha protein (hCRA alpha) mRNA, complete cds.
  • SMINT20110330//pKID domain
  • SMINT20122910//Mus musculus StAR-related protein 1-4E mRNA, partial cds.
  • SMINT20131810//ENV polyprotein (coat polyprotein)
  • SMINT20168570//Homo sapiens mRNA for stabilin-1 (stab1 gene).
  • SPLEN20008390//Human placenta (Diff48) mRNA, complete cds.
  • SPLEN20084600//RING CANAL PROTEIN (KELCH PROTEIN).
  • SPLEN20128000//Xenopus laevis XMAB21 (Xmab-21) mRNA, complete cds.
  • SPLEN20149110//Dishevelled specific domain
  • SPLEN20171470//Keratin, high sulfur B2 protein
  • SPLEN20194050//Homo sapiens HOTTL protein mRNA, complete cds.
  • SPLEN20214580//Mus musculus mdg1-1 mRNA, complete cds.
  • STOMA20057820//Uncharacterized protein family UPF0024
  • STOMA20063980//Collagen triple helix repeat (20 copies)
  • STOMA20069040//Keratin, high sulfur B2 protein
  • SYNOV20017080//UBX domain
  • TBAES20000590//Cytochrome P450// Cytochrome P450
  • TESTI20001170//HORMA domain
  • TESTI20031810//Bacterial luciferase// Domain of unknown function DUF28
  • TESTI20044230//Mus musculus testis-specific Y-encoded-like protein (Tspyl1) mRNA, complete cds.
  • TESTI20098350//VAT-Nn domain
  • TESTI20157520//K+ channel tetramerisation domain// K+ channel tetramerisation domain
  • TESTI20170350//Cystine-knot domain
  • TESTI20192800//Homo sapiens nasopharyngeal carcinoma susceptibility protein LZ16 mRNA, complete cds.
  • TESTI20199750//TRICHOHYALIN.
  • TESTI20202650//Repeat in HS1/Cortactin
  • TESTI20229600//Drosophila melanogaster SP2353 mRNA, complete cds.
  • TESTI20231920//Gag P30 core shell protein
  • TESTI20242830//E2 (early) protein, C terminal// Syndecan domain
  • TESTI20254540//Homo sapiens hepatocellular carcinoma-associated antigen 59 mRNA, complete cds.
  • TESTI20320440//THIOREDOXIN.
  • TESTI20327680//EF hand// EF hand
  • TESTI20328280//KE2 family protein// Troponin
  • TESTI20351830//K-box region
  • TESTI20370020//Bleomycin resistance protein
  • TESTI20391210//IQ calmodulin-binding motif
  • TESTI20408150//Keratin, high sulfur B2 protein
  • TESTI20451990//SAP domain
  • TESTI20467970//Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain// Neurohypophysial hormones, N-terminal Domain
  • THYMU20108310//Mouse NCBP-29 mRNA for PW29, complete cds.
  • THYMU20142040//WISKOTT-ALDRICH SYNDROME PROTEIN HOMOLOG (WASP).
  • THYMU20194360//Kelch motif
  • THYMU20239000//collagen alpha 1(XI) chain
  • TOVAR20004760//Leucine Rich Repeat// Leucine Rich Repeat// Leucine Rich Repeat
  • TRACH20005020//Ank repeat// MutT-like domain
  • TRACH20007020//TRICHOHYALIN.
  • TRACH20048450//PROTEIN K4 (PROTEIN K3).
  • TRACH20068700//Homo sapiens adaptor protein CIKS mRNA, complete cds.
  • TRACH20076760//Keratin, high sulfur B2 protein
  • TRACH20135520//TBC domain// Rhodanese-like domain
  • TRACH20141240//Mus musculus G21 protein mRNA, complete cds.
  • TRACH20183170//Rattus norvegicus Sprague-Dawley SM-20 mRNA, complete cds.
  • UTERU20000740//Human fusion protein mRNA, complete cds.
  • UTERU20004240//CGI-96 protein
  • UTERU20006960//endoplasmic reticulum resident protein 58
  • UTERU20022940//Human (p23) mRNA, complete cds.
  • UTERU20046640//Mus musculus ld1Bp (LDLB) mRNA, complete cds.
  • UTERU20065930//GTP-RHO BINDING PROTEIN 1 (RHOPHILIN).
  • UTERU20115740//Human PMS2 related (hPMSR3) gene, complete cds.
  • UTERU20179880//TPR Domain// TPR Domain// TPR Domain// TPR Domain
  • With respect to the remaining 882 clones, there are so far no information available for estimating their functions. However, there is the possibility that the functions of these clones will be revealed in future. Their Clone Names are indicated below.
  • 3NB6920014080, ADRGL20000640, ADRGL20012870, ADRGL20013010, ADRGL20044590, ADRGL20067670, ADRGL20068170, ADRGL20068460, ADRGL20073570, ADRGL20076360, ADRGL20083310, ASTRO20032120, ASTRO20100720, ASTRO20111490, ASTRO20114610, ASTRO20136710, ASTRO20138020, ASTRO20152140, ASTRO20166810, ASTRO20173480, BLADE20004630, BRACE20019540, BRACE20037660, BRACE20038850, BRACE20051690, BRACE20054500, BRACE20055180, BRACE20056810, BRACE20057420, BRACE20058810, BRACE20060840, BRACE20061740, BRACE20062400, BRACE20062740, BRACE20063800, BRACE20063930, BRACE20082950, BRACE20090440, BRACE20096540, BRACE20097320, BRACE20099570, BRACE20106690, BRACE20109370, BRACE20109830, BRACE20111830, BRACE20114780, BRACE20115450, BRACE20118380, BRACE20121850, BRACE20136240, BRACE20141080, BRACE20142320, BRACE20142570, BRACE20148210, BRACE20150310, BRACE20152870, BRACE20163150, BRACE20165830, BRACE20171240, BRACE20175870, BRACE20190440, BRACE20220300, BRACE20223280, BRACE20229280, BRACE20230700, BRACE20235400, BRACE20262930, BRACE20262940, BRACE20266750, BRACE20267250, BRACE20269710, BRACE20283920, BRACE20287410, BRALZ20014450, BRALZ20019660, BRALZ20059500, BRALZ20065600, BRALZ20075450, BRALZ20075760, BRALZ20080310, BRALZ20088690, BRAMY10001570, BRAMY20004110, BRAMY20011140, BRAMY20071850, BRAMY20102080, BRAMY20110640, BRAMY20116790, BRAMY20121190, BRAMY20137560, BRAMY20147540, BRAMY20160700, BRAMY20163250, BRAMY20163270, BRAMY20167710, BRAMY20168920, BRAMY20170140, BRAMY20178640, BRAMY20182730, BRAMY20183080, BRAMY20196000, BRAMY20204450, BRAMY20205740, BRAMY20229840, BRAMY20230600, BRAMY20250240, BRAMY20250320, BRAMY20261680, BRAMY20267130, BRAMY20268990, BRAMY20277140, BRAMY20280720, BRAMY20285930, BRAMY20286820, BRAWH10000930, BRAWH20012410, BRAWH20014920, BRAWH20016660, BRAWH20100690, BRAWH20103180, BRAWH20106180, BRAWH20107540, BRAWH20110660, BRAWH20111550, BRAWH20122770, BRAWH20126190, BRAWH20126980, BRAWH20139410, BRAWH20142340, BRAWH20147290, BRAWH20155950, BRAWH20158530, BRAWH20160280, BRAWH20162690, BRAWH20166790, BRAWH20173050, BRAWH20182060, BRCAN20006200, BRCAN20006390, BRCAN20060190, BRCAN20126130, BRCAN20143700, BRCAN20147880, BRCAN20216690, BRCAN2.0237240, BRCAN20263400, BRCAN20273100, BRCAN20273340, BRCAN20275130, BRCAN20280400, BRCAN20284600, BRCOC20004870, BRCOC20020850, BRCOC20031000, BRCOC20031870, BRCOC20037400, BRCOC20093800, BRCOC20105100, BRCOC20117690, BRCOC20119960, BRCOC20122290, BRCOC20128130, BRCOC20135730, BRCOC20147480, BRCOC20148330, BRCOC20155970, BRCOC20158240, BRHIP10001740, BRHIP20104440, BRHIP20105710, BRHIP20107440, BRHIP20110800, BRHIP20115760, BRHIP20123140, BRHIP20129720, BRHIP20139720, BRHIP20140630, BRHIP20142850, BRHIP20143860, BRHIP20149540, BRHIP20153560, BRHIP20169680, BRHIP20169900, BRHIP20170100, BRHIP20173150, BRHIP20180140, BRHIP20186120, BRHIP20186500, BRHIP20190070, BRHIP20196410, BRHIP20205090, BRHIP20208420, BRHIP20214950, BRHIP20227080, BRHIP20230710, BRHIP20232290, BRHIP20238690, BRHIP20240460, BRHIP20254480, BRHIP20277620, BRHIP20284800, BRHIP30001110, BRSSN10000920, BRSSN20006340, BRSSN20015030, BRSSN20028570, BRSSN20038410, BRSSN20046570, BRSSN20046860, BRSSN20097020, BRSSN20105960, BRSSN20108300, BRSSN20121030, BRSSN20152380, BRSSN20159070, BRSSN20159820, BRSTN20000580, BRTHA20046390, CD34C30001250, CD34C30003140, CD34C30004940, COLON20043180, CTONG20002180, CTONG20028410, CTONG20038890, CTONG20049410, CTONG20077790, CTONG20082690, CTONG20091320, CTONG20095270, CTONG20095290, CTONG20096430, CTONG20097660, CTONG20099630, CTONG20101480, CTONG20105660, CTONG20106230, CTONG20108210, CTONG20124470, CTONG20126070, CTONG20128470, CTONG20136300, CTONG20138030, CTONG20139070, CTONG20140320, CTONG20141650, CTONG20146970, CTONG20147050, CTONG20150910, CTONG20158150, CTONG20162170, CTONG20163550, CTONG20164990, CTONG20265130, CTONG20273610, D3OST10002670, D3OST10002700, D3OST20006540, D3OST20007340, D3OST20024170, D3OST20024520, D3OST20037970, D3OST30002910, D6OST20004450, D9OST20000310, D9OST20035800, DFNES10000030, DFNES10001850, DFNES20010910, DFNES20055270, DFNES20082800, FCBBF10003740, FCBBF20006780, FCBBF20023700, FCBBF20035280, FCBBF20054280, FCBBF20056370, FCBBF20071860, FCBBF20072650, FCBBF20075560, FCBBF20076330, FCBBF30001840, FCBBF30016570, FCBBF30019120, FCBBF30028180, FCBBF30052180, FCBBF30062880, FCBBF30070770, FCBBF30071520, FCBBF30170590, FCBBF30178730, FCBBF30189490, FCBBF30199610, FCBBF30240020, FCBBF30242250, FCBBF30262360, FCBBF30266780, FCBBF30266920, FCBBF30278630, FCBBF30284720, FCBBF40001420, FCBBF40005480, FEBRA20003210, FEBRA20017050, FEBRA20018280, FEBRA20025520, FEBRA20026280, FEBRA20027810, FEBRA20034360, FEBRA20037500, FEBRA20042190, FEBRA20052910, FEBRA20060610, FEBRA20072120, FEBRA20079310, FEBRA20082100, FEBRA20095140, FEBRA20098460, FEBRA20161120, FEBRA20166540, FEBRA20176800, FEBRA20197110, FEBRA20204000, FEBRA20204060, FEBRA20216360, FEBRA20226010, FEBRA20229560, FEBRA20232850, FELNG20002410, HCHON20002260, HCHON20008980, HCHON20009350, HCHON20011160, HCHON20014970, HCHON20022470, HCHON20036760, HCHON20043590, HCHON20067220, HCHON20074820, HCHON20076500, HEART20021840, HEART20037810, HEART20049400, HEART20063340, HEART20067870, HEART20067890, HEART20074430, HEART20089940, HEART20095990, HHDPC10000650, HHDPC20006920, HHDPC20057940, HHDPC20095280, HLUNG20016770, HLUNG20084390, KIDNE20006780, KIDNE20011170, KIDNE20013730, KIDNE20018730, KIDNE20018970, KIDNE20021980, KIDNE20029800, KIDNE20067330, KIDNE20079440, KIDNE20096280, KIDNE20096470, KIDNE20100840, KIDNE20102650, KIDNE20104300, KIDNE20106740, KIDNE20107500, KIDNE20112000, KIDNE20120090, KIDNE20122910, KIDNE20132180, KIDNE20138010, KIDNE20141190, KIDNE20144890, KIDNE20148900, KIDNE20163880, KIDNE20180710, KIDNE20186780, LIVER10001260, LIVER20011910, LIVER20028420, LIVER20038540, LIVER20084730, LIVER20085800, MESAN20106640, MESAN20121130, MESAN20132110, MESAN20138450, MESAN20157080, MESAN20161590, MESAN20164090, MESAN20182090, NESOP10001080, NOVAR10001020, NOVAR20003520, NT2NE20003740, NT2NE20010210, NT2NE20015240, NT2NE20043780, NT2NE20053580, NT2NE20072200, NT2NE20074250, NT2NE20089610, NT2NE20108540, NT2NE20110360, NT2NE20146810, NT2NE20152750, NT2NE20172590, NT2NE20174800, NT2NE20174920, NT2NE20187390, NT2RI20022600, NT2RI20023160, NT2RI20023590, NT2RI20036670, NT2RI20055790, NT2RI20069730, NT2RI20198260, NT2RI20203900, NT2RI20207030, NT2RI20216250, NT2RI20244960, NT2RI20250750, NT2RI20252550, NT2RP70010740, NT2RP70056750, NT2RP70075240, NT2RP70077660, NT2RP70085440, NT2RP70110860, NT2RP70111320, NT2RP70130020, NT2RP70137640, NT2RP70143480, NT2RP70147210, NT2RP70150800, NT2RP70169110, NT2RP70175670, NT2RP70181970, NT2RP70190640, NT2RP70203790, NTONG20050620, NTONG20050860, NTONG20065010, NTONG20077560, NTONG20090680, OCBBF20005230, OCBBF20020150, OCBBF20029800, OCBBF20032460, OCBBF20041680, OCBBF20045330, OCBBF20047570, OCBBF20048660, OCBBF20051610, OCBBF20060300, OCBBF20061720, OCBBF20062140, OCBBF20062410, OCBBF20074140, OCBBF20076220, OCBBF20079460, OCBBF20081380, OCBBF20084660, OCBBF20085200, OCBBF20088220, OCBBF20094240, OCBBF20097720, OCBBF20100400, OCBBF20103130, OCBBF20104040, OCBBF20105570, OCBBF20107920, OCBBF20111770, OCBBF20118970, OCBBF20126780, OCBBF20130110, OCBBF20139260, OCBBF20151150, OCBBF20164050, OCBBF20164670, OCBBF20170690, OCBBF20173060, OCBBF20173250, OCBBF20178990, OCBBF20186870, OCBBF20189560, PEBLM20024550, PEBLM20071880, PEBLM20072960, PERIC20002140, PERIC20003860, PLACE60004630, PLACE60119750, PLACE60138830, PLACE60153220, PLACE60155130, PLACE60169420, PLACE60181070, PLACE60187690, PLACE60188340, PROST10004800, PROST20005670, PROST20021010, PROST20024890, PROST20029270, PROST20052280, PROST20057930, PROST20059040, PROST20087700, PROST20097950, PROST20111050, PROST20120050, PROST20121900, PROST20123530, PROST20127400, PROST20130530, PROST20132600, PROST20133270, PROST20144220, PROST20149160, PROST20149250, PROST20151240, PROST20152460, PROST20153320, PROST20166680, PROST20168290, PROST20178360, PUAEN20025680, PUAEN20027580, PUAEN20044000, PUAEN20045110, PUAEN20045250, PUAEN20052470, PUAEN20081230, PUAEN20085150, RECTM10001410, RECTM20003490, RECTM20005100, SKMUS20012010, SKMUS20031680, SKMUS20046670, SKNMC20006220, SKNSH20034660, SKNSH20062340, SKNSH20080430, SKNSH20087770, SKNSH20091970, SMINT20005410, SMINT20008240, SMINT20011140, SMINT20011580, SMINT20014580, SMINT20015590, SMINT20023280, SMINT20033170, SMINT20033400, SMINT20042990, SMINT20047810, SMINT20056210, SMINT20058000, SMINT20060780, SMINT20065960, SMINT20076470, SMINT20080540, SMINT20089170, SMINT20092330, SMINT20092720, SMINT20098320, SMINT20103690, SMINT20105000, SMINT20108530, SMINT20109970, SMINT20122850, SMINT20132280, SMINT20153530, SMINT20158100, SMINT20161220, SMINT20162860, SMINT20164400, SMINT20164770, SMINT20173190, SPLEN10000830, SPLEN20000640, SPLEN20002220, SPLEN20008820, SPLEN20013540, SPLEN20016260, SPLEN20019450, SPLEN20020070, SPLEN20022230, SPLEN20023140, SPLEN20031600, SPLEN20032040, SPLEN20032190, SPLEN20033960, SPLEN20040600, SPLEN20076530, SPLEN20101190, SPLEN20106250, SPLEN20129610, SPLEN20146690, SPLEN20149190, SPLEN20152610, SPLEN20157300, SPLEN20158900, SPLEN20158990, SPLEN20160690, SPLEN20160980, SPLEN20166270, SPLEN20171210, SPLEN20176200, SPLEN20193110, SPLEN20198110, SPLEN20204170, SPLEN20212950, SPLEN20214400, SPLEN20225220, SPLEN20242320, SPLEN20242730, SPLEN20249560, SPLEN20261440, SPLEN20264110, SPLEN20279950, SPLEN20280660, SPLEN20303970, STOMA20013890, STOMA20026880, STOMA20036460, STOMA20048520, STOMA20048840, STOMA20062290, STOMA20067800, STOMA20072690, STOMA20076800, STOMA20086140, STOMA20092560, SYNOV20003970, TCOLN20001390, TESOP20000900, TESOP20003120, TESTI10000940, TESTI20004890, TESTI20011200, TESTI20018230, TESTI20029930, TESTI20030310, TESTI20030890, TESTI20038270, TESTI20066770, TESTI20076850, TESTI20086210, TESTI20087620, TESTI20094020, TESTI20098530, TESTI20102800, TESTI20105720, TESTI20112940, TESTI20114070, TESTI20116650, TESTI20122310, TESTI20129150, TESTI20129220, TESTI20130120, TESTI20135660, TESTI20136990, TESTI20137370′, TESTI20137670, TESTI20143240, TESTI20143620, TESTI20155900, TESTI20157100, TESTI20159140, TESTI20161970, TESTI20168630, TESTI20168960, TESTI20169960, TESTI20171020, TESTI20178160, TESTI20179320, TESTI20183370, TESTI20185810, TESTI20192280, TESTI20194300, TESTI20194810, TESTI20199170, TESTI20200260, TESTI20203440, TESTI20209460, TESTI20211240, TESTI20213150, TESTI20213580, TESTI20220100, TESTI20220650, TESTI20224620, TESTI20226490, TESTI20234270, TESTI20238000, TESTI20239470, TESTI20240090, TESTI20241530, TESTI20241920, TESTI20244760, TESTI20262330, TESTI20262910, TESTI20265250, TESTI20265370, TESTI20269570, TESTI20272060, TESTI20272390, TESTI20275620, TESTI20277360, TESTI20278200, TESTI20280980, TESTI20282540, TESTI20285830, TESTI20288110, TESTI20289850, TESTI20291620, TESTI20294700, TESTI20297850, TESTI20301360, TESTI20305560, TESTI20307540, TESTI20310070, TESTI20311290, TESTI20319190, TESTI20327740, TESTI20330310, TESTI20333950, TESTI20336410, TESTI20337100, TESTI20342430, TESTI20345060, TESTI20347740, TESTI20347770, TESTI20357750, TESTI20357930, TESTI20361140, TESTI20367360, TESTI20369130, TESTI20369220, TESTI20370550, TESTI20371060, TESTI20378450, TESTI20380650, TESTI20386230, TESTI20386440, TESTI20388580, TESTI20391130, TESTI20392090, TESTI20401430, TESTI20406420, TESTI20409440, TESTI20413300, TESTI20415640, TESTI20419560, TESTI20423020, TESTI20424000, TESTI20424730, TESTI20425070, TESTI20427830, TESTI20428060, TESTI20429280, TESTI20429580, TESTI20433130, TESTI20438660, TESTI20447540, TESTI20451710, TESTI20458190, TESTI20465520, TESTI20468630, TESTI20471470, TESTI20471530, TESTI20472120, TESTI20473420, TESTI20477920, TESTI20478010, TESTI20478180, TESTI20479300, THYMU20000570, THYMU20011950, THYMU20015210, THYMU20018190, THYMU20029100, THYMU20045120, THYMU20058070, THYMU20061700, THYMU20070360, THYMU20075320, THYMU20095960, THYMU20101610, THYMU20101920, THYMU20111420, THYMU20114470, THYMU20118060, THYMU20119390, THYMU20128070, THYMU20128260, THYMU20142970, THYMU20153160, THYMU20158250, THYMU20186390, THYMU20186730, THYMU20187720, THYMU20195990, THYMU20204160, THYMU20204990, THYMU20215090, THYMU20215970, THYMU20226600, THYMU20228540, THYMU20235760, THYMU20239430, THYMU20246840, THYMU20250420, THYMU20251890, THYMU20253250, THYMU20255570, THYMU20255720, THYMU20259090, THYMU20265300, THYMU20271250, THYMU20272490, THYMU20283790, THYMU20284120, THYMU20286290, THYMU20286320, TKIDN20030590, TKIDN20030620, TOVAR20005750, TRACH20027840, TRACH20032720, TRACH20037360, TRACH20056980, TRACH20060150, TRACH20082780, TRACH20091230, TRACH20092680, TRACH20099340, TRACH20107710, TRACH20115740, TRACH20118940, TRACH20147250, TRACH20153810, TRACH20169800, TRACH20187180, TSTOM10001860, TSTOM20001390, TSTOM20003150, UMVEN20003540, UTERU20006290, UTERU20020010, UTERU20054460, UTERU20056010, UTERU20059050, UTERU20061030, UTERU20067050, UTERU20068990, UTERU20070040, UTERU20070810, UTERU20081300, UTERU20084260, UTERU20095380, UTERU20095400, UTERU20101240, UTERU20114100, UTERU20118110, UTERU20118970, UTERU20119680, UTERU20124070, UTERU20126880, UTERU20134910, UTERU20143980, UTERU20146680, UTERU20150870, UTERU20164260, UTERU20188810
    • EXAMPLE 7 Expression Frequency Analysis in Silico
  • The cDNA libraries derived from various tissues and cells as indicated in Example 1 were prepared, and cDNA clones were selected from each library at random. The 5′-end sequences were determined and the database was constructed based on the data. The database was constructed based on the nucleotide sequences of 1,402,070 clones, and thus the population of the database is large enough for the analysis.
  • Then, clones having a homologous sequence are categorized into a single cluster (clustering) by searching the nucleotide sequences of respective clones in this database with the program of nucleotide sequence homology search; the number of clones belonging to each cluster was determined and normalized for every library; thus, the ratio of a certain gene in each cDNA library was determined. This analysis gave the information of the expression frequency of genes in tissues and cells which were sources of the cDNA libraries.
  • Then, in order to analyze the expression of a gene containing the nucleotide sequence of the cDNA of the present invention in tissues and cells, the library derived from a tissue or a cell used in the large-scale cDNA analysis was subjected to the comparison of the expression levels between tissues or cells. Namely, the expression frequency was analyzed by comparing the previously normalized values between tissues and/or cells for which the nucleotide sequences of 600 or more cDNA clones had been analyzed. By this analysis, some of the genes were revealed to be involved in the pathology and functions indicated below. Each value in Tables 3 to 51 shown below represents a relative expression frequency; the higher the value, the higher the expression level.
  • Osteoporosis-Related Genes
  • Osteoporosis is a pathology in which bones are easily broken owing to overall decrease in components of bone. The onset involves the balance between the functions of osteoblast producing bone and osteoclast absorbing bone, namely bone metabolism. Thus, the genes involved in the increase of osteoclasts differentiating from precursor cells of monocyte/macrophage line (Molecular Medicine 38. 642-648. (2001)) are genes involved in osteoporosis relevant to bone metabolism.
  • A nucleotide sequence information-based analysis was carried out to identify the genes whose expression frequencies are higher or lower in CD34+ cell (cell expressing a glycoprotein CD34) treated with the osteoclast differentiation factor (Molecular Medicine 38. 642-648. (2001)) than in the untreated CD34+ cell, which is the precursor cell of monocyte/macrophage line. The result of comparative analysis for the frequency between the two cDNA libraries prepared from the RNA of CD34+ cells (CD34C) and from the RNA of CD34+ cells treated with the osteoclast differentiation factor (D30ST, D60ST or D90ST) showed that the genes whose expression levels were different between the two were the following clones (Table 3).
  • ASTRO20001410, D30ST10001090, D30ST20036070, THYMU20039810, KIDNE20028720, BRAWH10000930, BRHIP20005340, CTONG20141650, D9OST20000310, D90ST20002780, D90ST20023970, D90ST20026730, D9OST20031370, D9OST20033970, D9OST20035800, D9OST20035940, D9OST20040180, FCBBF30018550, FCBBF30233680, KIDNE20102650, NT2RI20023160, PROST20107820, SKNSH20089400, SMINT20033400, CTONG20108210, D60ST20003580, D60ST20005070, ASTRO20155290, D3OST10002670, D3OST10002700, D3OST20006180, D3OST20006540, D3OST20007340, D3OST20013280, D3OST20024170, D3OST20024360, D3OST20037970, D3OST30002580, D3OST30002910, FCBBF10004120, NT2RI20001330, NTONG20009770, SPLEN20084600, SPLEN20140800, THYMU20169680, TRACH20141240, CD34C30001250, CD34C30003140, CD34C30004240, CD34C30004940, DFNES10001850, HHDPC20034390, NT2RI20091730, SKMUS20003610, SPLEN20225220, BRCOC20101230
  • These genes are involved in osteoporosis.
  • Genes involved in neural cell differentiation
  • Genes involved in neural cell differentiation are useful for treating neurological diseases. Genes with varying expression levels in response to induction of cellular differentiation in neural cells are thought to be involved in neurological diseases.
  • A survey was performed for genes whose expression levels are varied in response to induction of differentiation (stimulation by retinoic acid (RA) or growth inhibitor treatment after RA stimulation) in cultured cells of a neural strain, NT2. The result of comparative analysis of cDNA libraries derived from undifferentiated NT2 cells (NT2RM) and the cells subjected to the differentiation treatment (NT2RP, NT2R1 or NT2NE) showed that the genes whose expression levels were different between the two were the following clones (Table 4).
  • CTONG20027090, CTONG20160560, NT2RP70032610, OCBBF20188730, SPLEN20162680, BRCOC20101230, BRHIP20005340, BRHIP20238880, FCBBF30016320, FEBRA20080810, FEBRA20225040, HCHON20008320, HHDPC20034390, HLUNG10000550, NT2RI20028470, NT2RI20054050, NT2RI20091730, NT2RP70078420, PUAEN20003740, THYMU20271250, BRACE20003070, BRACE20039040, BRAWH20004600, BRAWH20011710, BRCOC20121720, BRHIP20005530, D3OST10002700, HCHON20007380, HEART20072310, KIDNE20121880, MESAN20121130, NT2RI20022600, NT2RI20023160, NT2RI20086220, NT2RI20216250, NT2RP60000850, NT2RP70036880, NT2RP70043480, NT2RP70062230, NT2RP70081610, NT2RP70102350, NT2RP70130020, NT2RP70190640, OCBBF10001850, OCBBF20097720, OCBBF20173980, PEBLM20044520, SPLEN20173510, TRACH20007020, UTERU20065930, HCHON20022470, NT2NE20010490, NT2NE20174800, NT2NE20177520, PROST20087700, PROST20107820, SMINT20028820, TESTI20063830, ASTRO20125520, BRHIP30001110, HCHON20002260, HCHON20008150, KIDNE20002520, NT2NE20130190, NT2NE20158600, NT2RI20001330, NT2RI20025400, NT2RI20036670, NT2RI20048840, SKMUS20020840, BRACE20057190, BRACE20060550, BRACE20267250, BRAWH20107540, BRAWH20118230, CTONG20075860, CTONG20095290, FEBRA20086620, FEBRA20144170, FEBRA20196370, HLUNG20023340, NT2NE20003740, NT2NE20010050, NT2NE20010210, NT2NE20010400, NT2NE20015240, NT2NE20021620, NT2NE20043780, NT2NE20053580, NT2NE20068130, NT2NE20072200, NT2NE20074250, NT2NE20080170, NT2NE20089610, NT2NE20089970, NT2NE20108540, NT2NE20110360, NT2NE20118960, NT2NE20122430, NT2NE20124480, NT2NE20125050, NT2NE20131890, NT2NE20132170, NT2NE20142210, NT2NE20146810, NT2NE20152750, NT2NE20155110, NT2NE20156260, NT2NE20157470, NT2NE20159740, NT2NE20172590, NT2NE20174920, NT2NE20181650, NT2NE20183760, NT2NE20184900, NT2NE20187390, OCBBF20108430, RECTM20005100, SMINT20001760, SPLEN20169720, TESTI20265250, ASTRO10001650, ASTRO20033160, BRACE20011070, BRACE20039440, BRACE20151320, BRAMY20104640, BRAMY20137560, BRAMY20167060, BRAWH20028110, BRCAN20280360, BRCOC20004870, BRHIP20207990, BRHIP20217620, BRHIP20249110, BRSTN10000830, CTONG10000940, CTONG20004690, CTONG20050280, CTONG20105660, CTONG20125640, CTONG20133520, CTONG20186320, FCBBF10000770, FCBBF10002800, FCBBF10003770, FCBBF30018550, FCBBF30123470, FCBBF30246230, FEBRA20018280, FEBRA20095140, FEBRA20192420, HCHON20064590, HHDPC10000830, HLUNG20016770, HLUNG20033780, IMR3220002430, KIDNE20104300, MESAN20004570, MESAN20089360, NOVAR10000910, NT2RI20003480, NT2RI20005750, NT2RI20009870, NT2RI20023590, NT2RI20023910, NT2RI20025640, NT2RI20040930, NT2RI20041880, NT2RI20046080, NT2RI20050960, NT2RI20055790, NT2RI20056700, NT2RI20069730, NT2RI20076290, NT2RI20091940, NT2RI20198260, NT2RI20203900, NT2RI20207030, NT2RI20240080, NT2RI20244600, NT2RI20244960, NT2RI20250750, NT2RI20252550, NT2RI20273230, NTONG20067090, OCBBF10001750, OCBBF20047570, OCBBF20054760, OCBBF20059560, OCBBF20073540, OCBBF20125530, OCBBF20126780, OCBBF20127040, OCBBF20140890, SKMUS20003610, SKNSH20008190, SKNSH20080430, SMINT20144800, SPLEN20027440, SPLEN20095550, SPLEN20140800, TESTI20094020, TESTI20369690, TESTI20391770, TESTI20442760, TRACH20084720, TRACH20107710, TRACH20118940, UTERU20022940, ASTRO20108190, BGGI120006160, BRAMY20136210, BRAWH20016620, BRAWH20164460, BRCOC20144000, BRHIP20132860, BRSSN20146100, CTONG10000100, CTONG20103480, CTONG20108210, CTONG20139070, FCBBF10000240, FCBBF10000630, FCBBF20067810, FCBBF30010810, FCBBF30012810, FCBBF30013770, FCBBF30039020, FCBBF40001420, FEBRA10001880, FEBRA20082010, HHDPC20001040, KIDNE20021910, NT2RP60000770, NT2RP70010740, NT2RP70027380, NT2RP70037240, NT2RP70044280, NT2RP70045590, NT2RP70056750, NT2RP70063950, NT2RP70072690, NT2RP70077660, NT2RP70085440, NT2RP70105210, NT2RP70110860, NT2RP70111320, NT2RP70122910, NT2RP70125160, NT2RP70133740, NT2RP70134990, NT2RP70137290, NT2RP70137640, NT2RP70143480, NT2RP70147210, NT2RP70150800, NT2RP70157890, NT2RP70159960, NT2RP70169110, NT2RP70175670, NT2RP70179710, NT2RP70181970, NT2RP70188020, NT2RP70188710, NT2RP70192730, NT2RP70194450, NT2RP70195430, NT2RP70198350, NT2RP70203790, OCBBF20039250, OCBBF20080410, OCBBF20108190, OCBBF20108580, OCBBF20122620, OCBBF20130110, OCBBF20151150, OCBBF20189560, PROST10003220, TESTI20001720, TESTI20121550, TESTI20152460, TESTI20211240, TESTI20234140, UMVEN20003540, UTERU20006960, UTERU20094350, UTERU20164260
  • These genes are neurological disease-related genes. Cancer-related genes
  • It has been assumed that, distinct from normal tissues, cancer tissues express a distinct set of genes, and thus the expression can contribute to the carcinogenesis in tissues and cells. Thus, the genes whose expression patterns in cancer tissues are different from those in normal tissues are cancer-related genes. Search was carried out for the genes whose expression levels in cancer tissues were different from those in normal tissues.
  • The result of comparative analysis of cDNA libraries derived from breast tumor (TBAES) and normal breast (BEAST) showed that the genes whose expression levels were different between the two were the following clones (Table 5).
  • BRACE20039040, BRAMY20163250, BRCOC20031250, BRHIP20005340, BRHIP20217620, BRHIP30001110, FCBBF10000770, FCBBF30010810, FEBRA20080810, FEBRA20144170, FEBRA20196630, FEBRA20197110, HCHON20002260, HCHON20040020, HHDPC20034390, HLUNG10000550, NOVAR10000910, NT2RI20023160, NT2RI20054050, NT2RI20091730, OCBBF20188730, SMINT20144800, SPLEN20128000, SPLEN20171210, SPLEN20264110, TBAES20000590, TBAES20002550, TBAES20003150, TESTI20334410, TESTI20432750, TRACH20003590, TRACH20084720, UTERU20046640, BEAST20004540, SPLEN20008740
  • The result of comparative analysis of cDNA libraries derived cervical tumor (TCERX) and normal cervical duct (CERVX) showed that the genes whose expression levels were different between the two were the following clones (Table 6).
  • BGGI120006160, BRAMY20063970, BRHIP20218580, FEBRA20002100, SPLEN20162680, TESTI20214250, CTONG20105080, HCHON20015980, PROST20175290, TESTI20254220, THYMU20279750
  • The result of comparative analysis of cDNA libraries derived from colon tumor (TCOLN) and normal colon (COLON) showed that the genes whose expression levels were different between the two were the following clones (Table 7).
  • ASTRO20001410, BRAWH20162690, CTONG20132220, HCHON20002260, NT2RI20001330, TCOLN20001390, 3NB6910001910, BRAMY20120910, BRAWH20004600, BRCOC20031250, BRCOC20031870, COLON10001350, COLON20043180, COLON20093370, FEBRA20002100, FEBRA20082010, FEBRA20197110, KIDNE20007770, KIDNE20013730, NT2RP70045590, OCBBF20078920, PROST20083600, SPLEN20011410, TRACH20084720, THYMU20271250
  • The result of comparative analysis of cDNA libraries derived from esophageal tumor (TESOP) and normal esophagus (NESOP) showed that the genes whose expression levels were different between the two were the following clones (Table 8).
  • ASTRO20033160, ASTRO20125520, BRAMY20266850, BRAWH20164460, BRHIP20005340, BRHIP20191490, CTONG20095290, CTONG20143690, CTONG20161850, DFNES20001530, DFNES20071130, FCBBF30123470, FCBBF30175310, FEBRA20095140, HCHON20016650, MESAN20025190, NT2RI20028470, NT2RI20054050, NT2RP70036880, NTONG20009770, NTONG20064840, NTONG20076930, SMINT20042990, SPLEN20008820, SPLEN20128000, SPLEN20149110, STOMA20013890, TESOP20000900, TESOP20003120, TESOP20004000, TESOP20005270, TESOP20005690, TESTI20334410, THYMU20271250, TRACH20141240, UTERU20022940, NESOP10001080, NT2RI20023160, NTONG20013620, TRACH20077540, NTONG20015870
  • The result of comparative analysis of cDNA libraries derived from kidney tumor (TKIDN) and normal kidney (KIDNE) showed that the genes whose expression levels were different between the two were the following clones (Table 9).
  • ASTRO20008010, ASTRO20181690, BRACE20111830, BRACE20152870, BRACE20237270, BRAMY20147540, BRAMY20286820, BRAWH20015350, BRAWH20096780, BRAWH20132190, BRAWH20182060, BRCAN20060190, BRCOC20004870, BRCOC20176520, BRHIP20000870, BRHIP20198190, BRHIP20233090, BRHIP30001110, BRSSN20015790, BRSTN20000580, CTONG10000940, CTONG20098440, CTONG20150910, CTONG20165050, DFNES20014040, DFNES20037420, FCBBF10000770, FCBBF30083820, FCBBF30247930, FEBRA20037500, FEBRA20072120, FEBRA20080810, FEBRA20086620, FEBRA20140100, FEBRA20144170, FEBRA20176800, HCHON20008320, HCHON20059870, HLUNG10000550, MESAN20106640, NT2RI20025400, NT2RI20076290, NT2RI20091940, OCBBF20019830, OCBBF20022900, OCBBF20039250, OCBBF20080050, OCBBF20097720, OCBBF20125530, OCBBF20130110, OCBBF20140640, OCBBF20173980, PANCR10000910, PROST20087700, PUAEN20044000, SPLEN20144520, SPLEN20160980, TKIDN10000010, TKIDN20004640, TKIDN20005210, TKIDN20030590, TKIDN20030620, TKIDN20047480, TRACH20003590, TRACH20028030, TRACH20183170, TRACH20184490, UMVEN20003540, UTERU20004240, UTERU20055930, ASTRO10001650, ASTRO20108190, BGGI120006160, BRACE20039040, BRAMY20102080, BRAWH20004600, BRAWH20125380, BRAWH20162690, BRHIP20115760, BRHIP20205090, CTONG20052650, CTONG20108210, CTONG20128470, CTONG20133480, CTONG20139070, D90ST20000310, DFNES20001530, FCBBF10001820, FEBRA20002100, HCHON20008980, HCHON20016650, HLUNG20033780, KIDNE20002520, KIDNE20003940, KIDNE20006780, KIDNE20007210, KIDNE20007770, KIDNE20008010, KIDNE20009470, KIDNE20011170, KIDNE20011400, KIDNE20013730, KIDNE20017130, KIDNE20018730, KIDNE20018970, KIDNE20020150, KIDNE20021680, KIDNE20021910, KIDNE20021980, KIDNE20022620, KIDNE20024830, KIDNE20027250, KIDNE20027950, KIDNE20028390, KIDNE20028720, KIDNE20028830, KIDNE20029800, KIDNE20067330, KIDNE20079440, KIDNE20096280, KIDNE20096470, KIDNE20100070, KIDNE20100840, KIDNE20101370, KIDNE20101510, KIDNE20102650, KIDNE20102710, KIDNE20104300, KIDNE20106740, KIDNE20107390, KIDNE20107500, KIDNE20107620, KIDNE20109730, KIDNE20109890, KIDNE20112000, KIDNE20115080, KIDNE20118580, KIDNE20120090, KIDNE20121880, KIDNE20122910, KIDNE20124400, KIDNE20125630, KIDNE20126010, KIDNE20126130, KIDNE20127100, KIDNE20127450, KIDNE20127750, KIDNE20130450, KIDNE20131580, KIDNE20132180, KIDNE20137340, KIDNE20138010, KIDNE20141190, KIDNE20144890, KIDNE20148900, KIDNE20163880, KIDNE20180710, KIDNE20181660, KIDNE20182690, KIDNE20186780, KIDNE20190740, LIVER20035110, MESAN20025190, NT2RP70043480, PROST20107820, PROST20123530, PROST20161950, PUAEN20030180, SKMUS20003610, SMINT20033400, TBAES20000590, TESTI20044310, TESTI20082330, TRACH20032720, UTERU20099720
  • The result of comparative analysis of cDNA libraries derived from liver tumor (TLIVE) and normal liver (LIVER) showed that the genes whose expression levels were different between the two were the following clones (Table 10).
  • BRAWH20166790, CTONG20103480, HEART20005410, LIVER10001260, LIVER10004790, LIVER20002160, LIVER20011130, LIVER20011910, LIVER20028420, LIVER20035110, LIVER20035680, LIVER20038540, LIVER20045650, LIVER20055200, LIVER20055440, LIVER20059810, LIVER20062510, LIVER20064100, LIVER20064690, LIVER20075680, LIVER20080530, LIVER20084730, LIVER20085800, LIVER20087510, LIVER20091180, NTONG20063010, PROST20087700, PROST20107820, TRACH20005400, ASTRO20001410, ASTRO20125520, BRACE20152870, BRAMY20167060, BRAMY20181220, BRAMY20285160, BRCOC20001860, FEBRA20144170, HLUNG10000550, OCBBF20073540, OCBBF20088220, PLACE60169420, SMINT20152940, SPLEN20242320, THYMU20000570, TRACH20077540, UTERU20055930, UTERU20065930
  • The result of comparative analysis of cDNA libraries derived from lung tumor (TLUNG) and normal lung (HLUNG) showed that the genes whose expression levels were different between the two were the following clones (Table 11).
  • BRACE20096200, BRAWH20004600, BRAWH20030250, BRCAN20006390, BRCAN20280360, BRHIP20238880, CTONG10000940, CTONG20103480, CTONG20129960, CTONG20155180, FCBBF10001210, FEBRA20144170, FEBRA20197110, HCHON20002260, HHDPC20034390, HLUNG10000550, HLUNG20016330, HLUNG20016770, HLUNG20017120, HLUNG20023340, HLUNG20033780, HLUNG20084390, IMR3220002430, LIVER20028420, NOVAR20000380, NT2RI20023910, NT2RI20054050, NT2RI20091730, NT2RP70044280, OCBBF20020830, OCBBF20125530, PLACE60004630, PROST20057930, PROST20107820, PROST20185830, PUAEN20030180, SMINT20121220, SPLEN20002220, SPLEN20008740, SPLEN20054290, SPLEN20128000, SPLEN20157300, SPLEN20176200, SPLEN20179180, SPLEN20211940, STOMA20013890, TBAES20000590, TESTI20094230, TESTI20184620, TESTI20334410, THYMU20000570, THYMU20039810, TRACH20007020, TRACH20141240, TRACH20183170, ASTRO20108190, ASTRO20155290, BRHIP20096850, FEBRA20080810, MESAN20014500, SMINT20028820, SPLEN20162680
  • The result of comparative analysis of cDNA libraries derived from ovary tumor (TOVER) and normal ovary (NOVER) showed the genes whose expression levels were different between the two were the following clones (Table 12).
  • BGGI120006160, BRHIP20005340, BRHIP20191860, HHDPC20001040, NOVAR10000150, NOVAR10000910, NOVAR10001020, NOVAR20000380, NOVAR20003520, THYMU20271250, ASTRO20141350, BRAMY20157820, BRCOC20001860, HLUNG20016770, NT2RI20054050, NTONG20090600, PROST20087700, PUAEN20015860, SPLEN20029310, TOVAR20004760, TOVAR20005750, TRACH20079690, UTERU20004240
  • The result of comparative analysis of cDNA libraries derived from stomach tumor (TSTOM) and normal stomach (STOMA) showed that the genes whose expression levels were different between the two were the following clones (Table 13).
  • BRACE20060840, FEBRA20052910, HCHON20002260, HLUNG10000550, NTONG20009770, PROST20107820, THYMU20039810, TSTOM10001860, TSTOM20001390, TSTOM20003150, TSTOM20005690, ASTRO20125520, BRACE20039040, BRAMY20124260, BRCOC20031870, BRHIP20191860, CTONG20128470, FEBRA20037500, HCHON20040020, HHDPC10000830, IMR3220002430, KIDNE20007770, NOVAR20000380, NT2RI20054050, NT2RI20091730, PROST20130530, SPLEN20149110, SPLEN20157880, STOMA20001830, STOMA20005390, STOMA20005670, STOMA20006400, STOMA20006780, STOMA20006860, STOMA20008880, STOMA20010250, STOMA20013890, STOMA20026880, STOMA20032890, STOMA20034770, STOMA20036460, STOMA20046680, STOMA20048520, STOMA20048840, STOMA20051200, STOMA20056640, STOMA20056670, STOMA20057820, STOMA20062130, STOMA20062290, STOMA20063250, STOMA20063980, STOMA20064470, STOMA20067800, STOMA20069040, STOMA20072690, STOMA20076800, STOMA20077450, STOMA20080500, STOMA20083610, STOMA20086140, STOMA20088380, STOMA20092530, STOMA20092560, STOMA20092890, TESTI20184620, TRACH20003590, TRACH20183170, PROST20083600, TRACH20068660
  • The result of comparative analysis of cDNA libraries derived from uterine tumor (TUTER) and normal uterus (UTERU) showed that the genes whose expression levels were different between the two were the following clones (Table 14). DFNES10001850, NT2RI20023910, SMINT20144800, SPLEN20162680, TOVAR20004760, TUTER20002830, ASTRO20008010, ASTRO20033160, ASTRO20058630, ASTRO20105820, ASTRO20108190, BRACE20039040, BRACE20057190, BRACE20060840, BRACE20111830, BRACE20223330, BRAMY20266850, BRAWH20113430, BRAWH20126980, BRCOC20031870, BRCOC20107300, BRCOC20121720, BRCOC20155970, BRHIP20105710, BRHIP20191490, BRHIP20207990, BRHIP20217620, BRHIP20222280, BRHIP20238880, BRHIP20249110, BRSSN20018690, BRTHA20000570, CTONG10000940, CTONG10002770, CTONG20095290, CTONG20099380, CTONG20103480, CTONG20108210, CTONG20118250, CTONG20129960, CTONG20131560, CTONG20139070, CTONG20139340, CTONG20143690, CTONG20160560, D30ST30002580, FCBBF10000240, FCBBF10001820, FCBBF10003670, FCBBF10004120, FCBBF10005740, FCBBF30175310, FCBBF30240020, FCBBF30246230, FCBBF40001420, FEBRA20002100, FEBRA20004620, FEBRA20018280, FEBRA20025270, FEBRA20034360, FEBRA20037500, FEBRA20080810, FEBRA20082100, FEBRA20144170, FEBRA20225040, HCHON20002260, HCHON20007380, HCHON20015980, HCHON20016650, HCHON20022470, HCHON20040020, HCHON20076500, HEART20072310, HHDPC20034390, HLUNG10000550, HLUNG20016770, KIDNE20131580, LIVER20028420, MAMGL10000830, MESAN20171520, NOVAR10000150, NOVAR10000910, NT2NE20053580, NT2NE20159740, NT2NE20174920, NT2RI20023160, NT2RI20041880, NT2RI20054050, NT2RI20076290, NT2RI20273230, NT2RP60000770, NT2RP60000850, NT2RP70036880, NT2RP70043480, NT2RP70045590, NT2RP70056750, NT2RP70062230, NT2RP70081610, OCBBF10001750, OCBBF20006770, OCBBF20032460, OCBBF20039250, OCBBF20047570, OCBBF20054760, OCBBF20059560, OCBBF20068490, OCBBF20080050, OCBBF20094240, OCBBF20097720, OCBBF20103130, OCBBF20105570, OCBBF20140640, OCBBF20173980, OCBBF20180120, OCBBF20188730, OCBBF20189560, PEBLM20044520, PLACE60060420, PROST20087700, PROST20107820, PROST20149160, PROST20159240, PROST20176170, PROST20189770, PUAEN20003740, PUAEN20015860, SKMUS20003610, SKNSH20008190, SKNSH20080430, SMINT20026890, SMINT20029760, SMINT20068010, SMINT20110330, SMINT20121220, SPLEN20008390, SPLEN20011410, SPLEN20054290, SPLEN20128000, SPLEN20140800, SPLEN20145720, SPLEN20169720, SPLEN20179180, SPLEN20193110, SPLEN20194050, SPLEN20211940, SPLEN20212730, SPLEN20225220, TBAES20000590, TESTI20061110, TESTI20116830, TESTI20184620, TESTI20208710, TESTI20211240, TESTI20213580, TESTI20214250, TESTI20334410, TESTI20369130, TESTI20369690, TESTI20391770, THYMU20039810, THYMU20216840, THYMU20240710, TRACH20003590, TRACH20032720, TRACH20033230, TRACH20141240, TRACH20149970, UMVEN10001860, UTERU20000740, UTERU20004240, UTERU20006290, UTERU20020010, UTERU20022940, UTERU20030570, UTERU20040610, UTERU20046640, UTERU20046980, UTERU20050690, UTERU20054460, UTERU20055330, UTERU20055930, UTERU20056010, UTERU20059050, UTERU20061030, UTERU20064000, UTERU20064860, UTERU20065930, UTERU20067050, UTERU20068990, UTERU20070040, UTERU20070810, UTERU20076390, UTERU20081300, UTERU20084260, UTERU20094350, UTERU20095380, UTERU20095400, UTERU20097760, UTERU20099720, UTERU20101240, UTERU20114100, UTERU20115740, UTERU20116570, UTERU20118110, UTERU20118970, UTERU20119060, UTERU20119680, UTERU20120310, UTERU20124070, UTERU20126880, UTERU20134910, UTERU20135860, UTERU20143980, UTERU20144640, UTERU20145480, UTERU20146310, UTERU20146680, UTERU20150870, UTERU20151980, UTERU20158300, UTERU20158800, UTERU20161570, UTERU20164260, UTERU20168220, UTERU20176130, UTERU20176320, UTERU20178100, UTERU20179880, UTERU20183640, UTERU20185230, UTERU20186740, UTERU20188110, UTERU20188810, BRAWH10000930, CTONG20128470, UTERU20006960
  • The result of comparative analysis of cDNA libraries derived from tongue cancer (CTONG) and normal tongue (NTONG) showed that the genes whose expression levels were different between the two were the following clones (Table 15).
  • ADRGL20018300, ASTRO20058630, ASTRO20072210, ASTRO20108190, BRACE20003070, BRACE20039040, BRACE20060720, BRACE20061050, BRACE20210140, BRACE20276430, BRAMY20152110, BRAMY20266850, BRAMY20271400, BRAWH10000930, BRAWH20004600, BRCAN20280360, BRCOC20004870, BRHIP20005340, BRHIP20005530, BRHIP20238880, BRSSN20146100, CTONG10000100, CTONG10000220, CTONG10000620, CTONG10000930, CTONG10000940, CTONG10001650, CTONG10002770, CTONG20002180, CTONG20004690, CTONG20009770, CTONG20014280, CTONG20027090, CTONG20028410, CTONG20038890, CTONG20049410, CTONG20050280, CTONG20052650, CTONG20052900, CTONG20075860, CTONG20076130, CTONG20077790, CTONG20082690, CTONG20085950, CTONG20091080, CTONG20091320, CTONG20092570, CTONG20092580, CTONG20092680, CTONG20092700, CTONG20093950, CTONG20095270, CTONG20095290, CTONG20095340, CTONG20096430, CTONG20096750, CTONG20097660, CTONG20098440, CTONG20099380, CTONG20099550, CTONG20099630, CTONG20100240, CTONG20101480, CTONG20103480, CTONG20105080, CTONG20105660, CTONG20106230, CTONG20106520, CTONG20108210, CTONG20114290, CTONG20114740, CTONG20118150, CTONG20118250, CTONG20119200, CTONG20120770, CTONG20121010, CTONG20121580, CTONG20124010, CTONG20124220, CTONG20124470, CTONG20124730, CTONG20125540, CTONG20125640, CTONG20126070, CTONG20127450, CTONG20128470, CTONG20129960, CTONG20131490, CTONG20131560, CTONG20132220, CTONG20133390, CTONG20133480, CTONG20133520, CTONG20136300, CTONG20138030, CTONG20139070, CTONG20139340, CTONG20139860, CTONG20140320, CTONG20140580, CTONG20141650, CTONG20146300, CTONG20147050, CTONG20149460, CTONG20149950, CTONG20153300, CTONG20153580, CTONG20155180, CTONG20155400, CTONG20156780, CTONG20158040, CTONG20158150, CTONG20158660, CTONG20159530, CTONG20160560, CTONG20161850, CTONG20162170, CTONG20163550, CTONG20164990, CTONG20165050, CTONG20186320, CTONG20200310, CTONG20265130, CTONG20267700, CTONG20273610, FCBBF10000240, FCBBF10005740, FCBBF30123470, FCBBF30233680, FEBRA20025270, FEBRA20037500, HCHON20002260, HCHON20007380, HCHON20007510, HCHON20015350, HCHON20040020, HHDPC20034390, HLUNG10000550, KIDNE20002520, KIDNE20009470, KIDNE20115080, KIDNE20127100, LIVER20028420, MESAN20029400, NT2RI20023160, NT2RI20023910, NT2RI20091730, NT2RP70043480, NT2RP70078420, NT2RP70081610, OCBBF20006770, OCBBF20059560, OCBBF20073540, OCBBF20094240, OCBBF20108580, PEBLM20044520, PEBLM20071880, PROST20107820, PUAEN20030180, SKNSH20008190, SMINT20023280, SMINT20089170, SPLEN20179180, TESTI20094020, TESTI20094230, TESTI20152460, TESTI20184620, TESTI20211240, TESTI20442760, THYMU20039810, TRACH20028030, TRACH20141240, TSTOM20003150, UTERU20004240, UTERU20055930, UTERU20065930, UTERU20119060, UTERU20124070, BRACE20039440, BRACE20068590, FCBBF30018550, IMR3220002430, KIDNE20028830, NT2RI20028470, NT2RI20054050, NT2RI20086220, NTONG20009770, NTONG20013620, NTONG20028070, NTONG20029480, NTONG20029700, NTONG20046140, NTONG20048060, NTONG20049910, NTONG20050620, NTONG20050860, NTONG20051530, NTONG20052650, NTONG20056570, NTONG20061870, NTONG20063010, NTONG20064400, NTONG20064840, NTONG20065010, NTONG20066460, NTONG20067090, NTONG20067830, NTONG20070200, NTONG20070340, NTONG20075220, NTONG20076930, NTONG20077560, NTONG20083650, NTONG20088620, NTONG20090600, NTONG20090680, NTONG20092290, NTONG20092330, OCBBF20068490, SKMUS20001980, SMINT20138900, SPLEN20008390, SPLEN20162680, UTERU20134910, ASTRO20155290, FEBRA20080810, NT2RP70032610, NT2RP70036880, NTONG20015870, OCBBF20188730, SMINT20122910, SPLEN20099700
  • These genes are involved in cancers.
  • Further, there is a method to search for genes involved in development and differentiation: the expression frequency analysis in which the expression levels of genes are compared between developing or differentiating tissues and/or cells and adult tissues and/or cells. The genes involved in tissue development and/or differentiation are genes participating in tissue construction and expression of function, and thus are useful genes, which are available for regenerative medicine aiming at convenient regeneration of injured tissues.
  • Search was carried out for the genes whose expression frequencies were different between developing and/or differentiating tissues and/or cells, and adult tissues and/or cells, by using the information of gene expression frequency based on the database of the nucleotide sequences of 1,402,070 clones shown above.
  • The result of comparative analysis of cDNA libraries derived from fetal brain (FCBBF, FEBRA or OCBBF) and adult brain (BRACE, BRALZ, BRAMY, BRAWH, BRCAN, BRCOC, BRHIP, BRSSN, BRSTN or BRTHA) showed that the genes whose expression levels were different between the two were the following clones (Tables 16 to 48).
  • 3NB6910001910, ADRGL20018300, ASTRO20001410, ASTRO20033160, ASTRO20058630, ASTRO20064750, ASTRO20100720, ASTRO20141350, ASTRO20145760, ASTRO20181690, BGGI120006160, BRACE20006400, BRACE20011070, BRACE20019540, BRACE20027620, BRACE20037660, BRACE20038000, BRACE20038470, BRACE20038480, BRACE20038850, BRACE20039440, BRACE20039540, BRACE20050900, BRACE20051380, BRACE20051690, BRACE20052160, BRACE20053280, BRACE20053480, BRACE20053630, BRACE20054500, BRACE20055180, BRACE20057420, BRACE20057620, BRACE20057730, BRACE20058580, BRACE20058810, BRACE20060840, BRACE20060890, BRACE20061050, BRACE20061740, BRACE20062400, BRACE20062740, BRACE20063630, BRACE20063780, BRACE20063800, BRACE20063930, BRACE20064880, BRACE20068590, BRACE20069090, BRACE20081720, BRACE20082950, BRACE20096200, BRACE20096540, BRACE20097320, BRACE20101700, BRACE20101710, BRACE20106840, BRACE20107530, BRACE20108130, BRACE20108880, BRACE20109370, BRACE20109830, BRACE20114780, BRACE20115450, BRACE20115920, BRACE20116110, BRACE20116460, BRACE20118380, BRACE20121850, BRACE20141080, BRACE20142320, BRACE20147800, BRACE2014.8210, BRACE20148240, BRACE20150310, BRACE20151320, BRACE20152870, BRACE20153680, BRACE20154120, BRACE20163150, BRACE20163350, BRACE20165830, BRACE20171240, BRACE20172980, BRACE20175870, BRACE20177200, BRACE20179340, BRACE20185680, BRACE20188470, BRACE20190040, BRACE20190440, BRACE20192440, BRACE20195100, BRACE20201570, BRACE20220300, BRACE20223280, BRACE20223330, BRACE20224480, BRACE20224500, BRACE20228480, BRACE20229280, BRACE20230700, BRACE20232840, BRACE20235400, BRACE20237270, BRACE20238000, BRACE20240740, BRACE20248260, BRACE20253160, BRACE20253330, BRACE20257100, BRACE20262930, BRACE20262940, BRACE20266750, BRACE20267250, BRACE20269200, BRACE20269710, BRACE20273890, BRACE20274080, BRACE20283920, BRACE20284100, BRACE20286360, BRACE20287410, BRALZ20013500, BRALZ20014450, BRALZ20017430, BRALZ20018340, BRALZ20054710, BRALZ20058880, BRALZ20059500, BRALZ20064740, BRALZ20065600, BRALZ20069760, BRALZ20073760, BRALZ20075450, BRALZ20075760, BRALZ20077900, BRALZ20077930, BRALZ20080310, BRALZ20088690, BRAMY10001300, BRAMY10001570, BRAMY20000520, BRAMY20000860, BRAMY20002770, BRAMY20004110, BRAMY20011140, BRAMY20025840, BRAMY20039260, BRAMY20045240, BRAMY20054880, BRAMY20060920, BRAMY20063970, BRAMY20071850, BRAMY20102080, BRAMY20104640, BRAMY20110640, BRAMY20111960, BRAMY20116790, BRAMY20121190, BRAMY20121620, BRAMY20124260, BRAMY20134140, BRAMY20135900, BRAMY20136210, BRAMY20137560, BRAMY20144620, BRAMY20147540, BRAMY20148130, BRAMY20152110, BRAMY20153110, BRAMY20157820, BRAMY20160700, BRAMY20163250, BRAMY20163270, BRAMY20167060, BRAMY20167710, BRAMY20168920, BRAMY20170140, BRAMY20174550, BRAMY20178640, BRAMY20181220, BRAMY20182730, BRAMY20183080, BRAMY20184670, BRAMY20195090, BRAMY20204450, BRAMY20205740, BRAMY20210400, BRAMY20211390, BRAMY20211420, BRAMY20213100, BRAMY20215230, BRAMY20217460, BRAMY20218250, BRAMY20218670, BRAMY20229800, BRAMY20229840, BRAMY20230600, BRAMY20231720, BRAMY20240040, BRAMY20245300, BRAMY20247110, BRAMY20247280, BRAMY20248490, BRAMY20250240, BRAMY20250320, BRAMY20252180, BRAMY20252720, BRAMY20260910, BRAMY20261680, BRAMY20266850, BRAMY20267130, BRAMY20268990, BRAMY20270730, BRAMY20271400, BRAMY20273960, BRAMY20277140, BRAMY20277170, BRAMY20280720, BRAMY20284910, BRAMY20285160, BRAMY20285930, BRAMY20286820, BRAWH20002320, BRAWH20012390, BRAWH20014920, BRAWH20015350, BRAWH20015890, BRAWH20016660, BRAWH20016860, BRAWH20017010, BRAWH20018730, BRAWH20028110, BRAWH20029630, BRAWH20064050, BRAWH20075700, BRAWH20096780, BRAWH20100690, BRAWH20101360, BRAWH20103180, BRAWH20105840, BRAWH20106180, BRAWH20107540, BRAWH20110660, BRAWH20110790, BRAWH20110960, BRAWH20111550, BRAWH20112940, BRAWH20114000, BRAWH20117950, BRAWH20118230, BRAWH20122580, BRAWH20125380, BRAWH20126190, BRAWH20126980, BRAWH20132190, BRAWH20137480, BRAWH20138660, BRAWH20139410, BRAWH20142340, BRAWH20147290, BRAWH20149340, BRAWH20155950, BRAWH20158530, BRAWH20160280, BRAWH20162690, BRAWH20166790, BRAWH20171030, BRAWH20173050, BRAWH20182060, BRAWH20185060, BRCAN10001490, BRCAN20003460, BRCAN20006200, BRCAN20006390, BRCAN20054490, BRCAN20060190, BRCAN20064010, BRCAN20071190, BRCAN20091560, BRCAN20103740, BRCAN20124080, BRCAN20126130, BRCAN20143700, BRCAN20147880, BRCAN20216690, BRCAN20224720, BRCAN20237240, BRCAN20263400, BRCAN20273100, BRCAN20273340, BRCAN20273550, BRCAN20275130, BRCAN20279700, BRCAN20280210, BRCAN20280400, BRCAN20283190, BRCAN20283380, BRCAN2028460b, BRCAN20285450, BRCOC10000870, BRCOC20001860, BRCOC20004040, BRCOC20004870, BRCOC20006370, BRCOC20008160, BRCOC20008500, BRCOC20020850, BRCOC20021550, BRCOC20023230, BRCOC20026640, BRCOC20027510, BRCOC20031000, BRCOC20031250, BRCOC20031870, BRCOC20035130, BRCOC20037320, BRCOC20037400, BRCOC20041750, BRCOC20055420, BRCOC20059510, BRCOC20077690, BRCOC20090520, BRCOC20091960, BRCOC20093800, BRCOC20099370, BRCOC20101230, BRCOC20107300, BRCOC20110100, BRCOC20114180, BRCOC20117690, BRCOC20119960, BRCOC20121720, BRCOC20122290, BRCOC20128130, BRCOC20134480, BRCOC20135730, BRCOC20136750, BRCOC20144000, BRCOC20147480, BRCOC20148330, BRCOC20155970, BRCOC20158240, BRCOC20176520, BRCOC20178560, BRHIP10001290, BRHIP20000870, BRHIP20001630, BRHIP20096170, BRHIP20096850, BRHIP20103090, BRHIP20104440, BRHIP20105710, BRHIP20106100, BRHIP20107440, BRHIP20111200, BRHIP20115080, BRHIP20115760, BRHIP20118380, BRHIP20118910, BRHIP20119330, BRHIP20121410, BRHIP20123140, BRHIP20129720, BRHIP20132860, BRHIP20135100, BRHIP20137230, BRHIP20139720, BRHIP20140630, BRHIP20142850, BRHIP20143730, BRHIP20143860, BRHIP20149540, BRHIP20153560, BRHIP20153600, BRHIP20167880, BRHIP20169680, BRHIP20169900, BRHIP20170100, BRHIP20173150, BRHIP20174040, BRHIP20175420, BRHIP20180140, BRHIP20183690, BRHIP20186120, BRHIP20186500, BRHIP20189980, BRHIP20190070, BRHIP20191490, BRHIP20191770, BRHIP20194940, BRHIP20195890, BRHIP20196410, BRHIP20205090, BRHIP20207430, BRHIP20207990, BRHIP20208420, BRHIP20208590, BRHIP20227080, BRHIP20230710, BRHIP20232290, BRHIP20233090, BRHIP20234380, BRHIP20236950, BRHIP20238600, BRHIP20238690, BRHIP20240460, BRHIP20243470, BRHIP20249110, BRHIP20252450, BRHIP20253660, BRHIP20277620, BRHIP20283030, BRHIP20284800, BRHIP20285830, BRHIP20285930, BRHIP30004880, BRSSN10000920, BRSSN20013420, BRSSN20014260, BRSSN20015030, BRSSN20015790, BRSSN20018690, BRSSN20028570, BRSSN20038200, BRSSN20038410, BRSSN20039370, BRSSN20043040, BRSSN20046570, BRSSN20046790, BRSSN20046860, BRSSN20066110, BRSSN20097020, BRSSN20101100, BRSSN20105870, BRSSN20105960, BRSSN20108300, BRSSN20120810, BRSSN20121030, BRSSN20137020, BRSSN20142940, BRSSN20146100, BRSSN20151990, BRSSN20159070, BRSSN20159820, BRSSN20169050, BRSSN20176820, BRSSN20177570, BRSSN20187310, BRSTN20000580, BRSTN20005360, BRTHA20000570, BRTHA20004740, BRTHA20046290, BRTHA20046390, BRTHA20046420, CD34C30001250, CD34C30004240, CTONG10000100, CTONG20004690, CTONG20027090, CTONG20050280, CTONG20076130, CTONG20077790, CTONG20095290, CTONG20095340, CTONG20099380, CTONG20106520, CTONG20118250, CTONG20121010, CTONG20127450, CTONG20128470, CTONG20141650, CTONG20143690, CTONG20153300, CTONG20155180, CTONG20158150, CTONG20161850, CTONG20164990, CTONG20186320, D3OST10002700, D6OST20003580, D9OST20000310, D9OST20035800, DFNES20010910, DFNES20071130, HCHON20002260, HCHON20003220, HCHON20010990, HCHON20015350, HCHON20022470, HCHON20067220, HCHON20067700, HEART20003060, HEART20005410, HEART20061950, HEART20090000, HHDPC10000650, HHDPC20057940, HLUNG20033780, KIDNE20011170, KIDNE20027250, KIDNE20104300, KIDNE20107500, KIDNE20122910, KIDNE20127100, KIDNE20180710, LIVER10001260, LIVER20064100, LIVER20087510, MAMGL10000830, MESAN20031900, MESAN20036460, MESAN20106640, MESAN20164090, NOVAR10000150, NOVAR20000380, NT2NE20010400, NT2NE20010490, NT2NE20021620, NT2NE20122430, NT2NE20125050, NT2NE20174920, NT2RI20001330, NT2RI20023590, NT2RI20041880, NT2RI20046080, NT2RI20216250, NT2RI20252550, NT2RP60000770, NT2RP70045590, NT2RP70063950, NT2RP70195430, NT2RP70198350, NTONG20028070, NTONG20046140, NTONG20064840, NTONG20067830, NTONG20077560, PANCR10000910, PEBLM20024550, PEBLM20052820, PEBLM20074370, PERIC20004780, PLACE50000660, PLACE60079250, PLACE60136720, PLACE60138830, PROST20005670, PROST20050670, PROST20107820, PROST20111050, PROST20116600, PROST20120160, PROST20123530, PROST20161950, PROST20171280, PROST20175290, PROST20185830, PROST20191640, PUAEN20015860, PUAEN20030180, PUAEN20044000, PUAEN20078980, PUAEN20085150, PUAEN20108240, SKMUS20012010, SKNSH20062340, SMINT20013480, SMINT20042990, SMINT20053300, SMINT20076470, SMINT20092330, SMINT20101440, SMINT20121220, SMINT20121950, SMINT20122910, SMINT20130320, SMINT20131810, SMINT20144800, SMINT20163960, SPLEN20002220, SPLEN20008740, SPLEN20011410, SPLEN20016260, SPLEN20027440, SPLEN20029310, SPLEN20033960, SPLEN20054290, SPLEN20126190, SPLEN20128000, SPLEN20145720, SPLEN20146450, SPLEN20147110, SPLEN20149110, SPLEN20157880, SPLEN20158900, SPLEN20171210, SPLEN20179180, SPLEN20186430, SPLEN20204170, SPLEN20212730, SPLEN20214580, SPLEN20250390, STOMA20051200, STOMA20062290, STOMA20092890, SYNOV20003970, TESOP20005270, TESTI10000940, TESTI20001720, TESTI20002720, TESTI20004890, TESTI20011200, TESTI20035960, TESTI20037560, TESTI20044310, TESTI20061110, TESTI20063830, TESTI20086210, TESTI20152460, TESTI20168960, TESTI20170350, TESTI20208400, TESTI20213580, TESTI20214250, TESTI20254220, TESTI20258460, TESTI20330310, TESTI20334410, TESTI20366910, TESTI20391770, TESTI20432750, TESTI20455620, THYMU20000570, THYMU20058070, THYMU20066100, THYMU20075320, THYMU20081490, THYMU20100410, THYMU20101920, THYMU20108310, THYMU20119390, THYMU20126900, THYMU20128260, THYMU20169680, THYMU20193640, THYMU20209590, THYMU20235760, THYMU20239430, THYMU20240710, THYMU20253250, THYMU20286290, TKIDN10000010, TKIDN20005210, TKIDN20030590, TRACH20005020, TRACH20005400, TRACH20007020, TRACH20019960, TRACH20034840, TRACH20079690, TRACH20128110, TRACH20149970, TRACH20183170, UMVEN10001860, UMVEN20003540, UTERU20000740, UTERU20030570, UTERU20054460, UTERU20055930, UTERU20056010, UTERU20064860, UTERU20065930, UTERU20070040, UTERU20081300, UTERU20084260, UTERU20094350, UTERU20120310, UTERU20124070, UTERU20164260, UTERU20168220, UTERU20183640, ASTRO20032120, ASTRO20125520, BRACE20039040, BRACE20060720, BRACE20062640, BRACE20090440, BRACE20099570, BRACE20111830, BRACE20142570, BRAWH20128270, BRCAN20280360, BRHIP20110800, BRHIP20176420, BRSSN20003120, CTONG20105660, CTONG20124010, CTONG20133480, CTONG20139070, CTONG20160560, FCBBF10001210, FCBBF10001550, FCBBF10001710, FCBBF10001820, FCBBF10002430, FCBBF10002700, FCBBF10002800, FCBBF10003220, FCBBF10003740, FCBBF10003760, FCBBF10005060, FCBBF10005460, FCBBF10005500, FCBBF20006780, FCBBF20014270, FCBBF20023700, FCBBF20032970, FCBBF20035280, FCBBF20042170, FCBBF20042560, FCBBF20051220, FCBBF20054280, FCBBF20056370, FCBBF20064520, FCBBF20067810, FCBBF20071860, FCBBF20072650, FCBBF20076330, FCBBF30008470, FCBBF30010810, FCBBF30012350, FCBBF30012810, FCBBF30015940, FCBBF30019120, FCBBF30024750, FCBBF30028180, FCBBF30033050, FCBBF30039020, FCBBF30052180, FCBBF30054440, FCBBF30057290, FCBBF30062880, FCBBF30070770, FCBBF30071520, FCBBF30078290, FCBBF30083620, FCBBF30123470, FCBBF30170590, FCBBF30172550, FCBBF30175310, FCBBF30178730, FCBBF30190850, FCBBF30195640, FCBBF30199610, FCBBF30215060, FCBBF30225660, FCBBF30240960, FCBBF30242250, FCBBF30243640, FCBBF30247930, FCBBF30252520, FCBBF30252800, FCBBF30252850, FCBBF30262510, FCBBF30266780, FCBBF30266920, FCBBF30278630, FCBBF30279030, FCBBF30281880, FCBBF30284720, FCBBF30285280, FCBBF40001730, FCBBF40005480, HCHON20007380, HEART20072310, HHDPC20068620, HLUNG20023340, KIDNE20017130, KIDNE20028830, MESAN20014500, NT2RP70072690, NT2RP70137640, NTONG20067090, PLACE60004630, PROST20083600, PROST20189770, RECTM20003490, SKNSH20008190, SMINT20115880, SPLEN20169720, SPLEN20194050, SPLEN20284240, TESTI20083940, TESTI20213150, TESTI20254540, TESTI20265250, TRACH20118940, UTERU20145480, UTERU20146680, ASTRO20155290, BRAWH20030250, BRAWH20113430, BRAWH20122770, BRHIP20005340, BRHIP30001110, BRSTN20002200, CTONG20052900, CTONG20108210, DFNES20031920, FEBRA10001900, FEBRA20003210, FEBRA20007620, FEBRA20009090, FEBRA20010120, FEBRA20017050, FEBRA20018280, FEBRA20025270, FEBRA20025520, FEBRA20026110, FEBRA20026280, FEBRA20029860, FEBRA20034680, FEBRA20037260, FEBRA20040530, FEBRA20042190, FEBRA20052910, FEBRA20060610, FEBRA20072120, FEBRA20079310, FEBRA20082010, FEBRA20088360, FEBRA20090290, FEBRA20092890, FEBRA20093520, FEBRA20097310, FEBRA20113560, FEBRA20125070, FEBRA20132740, FEBRA20140100, FEBRA20161120, FEBRA20166540, FEBRA20167390, FEBRA20171380, FEBRA20176800, FEBRA20184330, FEBRA20192420, FEBRA20195820, FEBRA20196370, FEBRA20196630, FEBRA20197110, FEBRA20211710, FEBRA20214970, FEBRA20215500, FEBRA20216360, FEBRA20222040, FEBRA20223220, FEBRA20225040, FEBRA20226010, FEBRA20229560, FEBRA20229630, FEBRA20232850, FEBRA20235500, HCHON20040020, KIDNE20102650, NT2RP70037240, PEBLM20072960, PLACE60169420, SKMUS20003610, SMINT20026890, SMINT20033400, SPLEN20020070, SPLEN20079510, TESTI20001000, TESTI20094020, THYMU20027560, THYMU20180280, THYMU20271250, TRACH20003590, UMVEN10001560, UTERU20022940, UTERU20046640, UTERU20119060, UTERU20144640, UTERU20176130, ASTRO20008010, BRACE20276430, BRAMY20103570, BRAMY20120910, BRAMY20162510, BRAMY20196000, BRAWH20164460, BRCAN20273640, BRCOC20105100, BRHIP20198190, BRHIP20222280, BRHIP20254480, BRHIP30004570, CTONG20028410, CTONG20091080, CTONG20103480, CTONG20126070, CTONG20139340, DFNES20001530, HCHON20008150, HHDPC20001040, HLUNG20016330, HLUNG20017120, IMR3220002430, KIDNE20007210, KIDNE20021910, KIDNE20124400, MESAN10001260, MESAN20029400, MESAN20121130, MESAN20153910, NT2NE20159740, NT2NE20177520, NT2RI20086220, NT2RI20250750, NT2RP60000850, NT2RP70044280, NT2RP70056750, NT2RP70081610, NTONG20009770, OCBBF10000540, OCBBF10001750, OCBBF20006770, OCBBF20013890, OCBBF20019830, OCBBF20020150, OCBBF20020830, OCBBF20023570, OCBBF20028050, OCBBF20028650, OCBBF20029800, OCBBF20030280, OCBBF20030910, OCBBF20035930, OCBBF20037440, OCBBF20041680, OCBBF20045330, OCBBF20046120, OCBBF20046470, OCBBF20046690, OCBBF20048660, OCBBF20050770, OCBBF20051610, OCBBF20053430, OCBBF20053490, OCBBF20053730, OCBBF20054200, OCBBF20054760, OCBBF20060300, OCBBF20062140, OCBBF20062410, OCBBF20066390, OCBBF20071210, OCBBF20071840, OCBBF20072240, OCBBF20073540, OCBBF20074140, OCBBF20076220, OCBBF20079310, OCBBF20079460, OCBBF20081380, OCBBF20082830, OCBBF20085200, OCBBF20086400, OCBBF20086910, OCBBF20088140, OCBBF20088220, OCBBF20091150, OCBBF20100400, OCBBF20103130, OCBBF20104040, OCBBF20105570, OCBBF20107090, OCBBF20107920, OCBBF20108580, OCBBF20108630, OCBBF20109310, OCBBF20111770, OCBBF20116850, OCBBF20118970, OCBBF20120390, OCBBF20121390, OCBBF20122620, OCBBF20124360, OCBBF20127040, OCBBF20127140, OCBBF20127550, OCBBF20128120, OCBBF20129360, OCBBF20130910, OCBBF20132850, OCBBF20140890, OCBBF20145760, OCBBF20148280, OCBBF20151150, OCBBF20153340, OCBBF20153350, OCBBF20155060, OCBBF20164670, OCBBF20170690, OCBBF20173060, OCBBF20173250, OCBBF20178150, OCBBF20180840, OCBBF20186870, OCBBF20189560, PEBLM20044520, PEBLM20071880, PLACE60060420, PROST20047390, PUAEN20003740, SMINT20029760, SPLEN20008820, SPLEN20084600, SPLEN20095550, SPLEN20099700, SPLEN20140800, SPLEN20173510, SPLEN20211220, SPLEN20250170, STOMA20067800, TESTI20031270, TESTI20116830, TESTI20121550, TESTI20234140, TESTI20442760, THYMU20039810, THYMU20070360, TRACH20033230, TRACH20084720, BRACE20067430, BRAWH10000930, BRHIP20003120, BRSSN20152380, FEBRA20024100, FEBRA20027810, FEBRA20037500, FEBRA20082100, FEBRA20098460, FEBRA20144170, FEBRA20145780, FEBRA20233770, HHDPC10000830, MESAN20025190, MESAN20089360, NT2RI20048840, NT2RP70043480, OCBBF20032460, OCBBF20039250, OCBBF20049300, OCBBF20061720, OCBBF20078920, OCBBF20084660, OCBBF20087010, PROST20087700, PROST20153320, TRACH20135520, ADIPS20004250, ASTRO10001650, BRACE20056810, BRACE20059370, BRACE20106690, BRACE20210140, BRAWH20103290, BRAWH20121640, BRHIP20005530, BRHIP20217620, BRHIP20218580, BRHIP20238880, CTONG20075860, CTONG20129960, FCBBF10000240, FCBBF10000630, FCBBF10001150, FCBBF10004120, FCBBF10005740, FCBBF20075560, FCBBF30018550, FCBBF30025560, FCBBF30086440, FCBBF30090690, FCBBF30189490, FCBBF30233680, FCBBF30240020, HCHON20007510, HCHON20016650, HHDPC20095280, KIDNE20002520, KIDNE20009470, NT2RI20003480, NT2RI20055790, NT2RP70027380, NT2RP70032610, NT2RP70062230, OCBBF10001850, OCBBF20022900, OCBBF20026630, OCBBF20049840, OCBBF20059560, OCBBF20068490, OCBBF20071960, OCBBF20080410, OCBBF20094240, OCBBF20097720, OCBBF20108190, OCBBF20108430, OCBBF20126780, OCBBF20130110, OCBBF20139260, OCBBF20148730, OCBBF20149280, OCBBF20164050, OCBBF20173980, OCBBF20178880, OCBBF20180120, OCBBF20188730, PROST20057930, SPLEN20162680, SPLEN20211940, TESTI20184620, TESTI20211240, TESTI20369690, THYMU20141670, TRACH20028030, UTERU20099720, UTERU20135860, BRACE20057190, BRHIP20191860, BRHIP20214950, FCBBF10003670, FCBBF10004370, FCBBF30013770, FCBBF30095260, FCBBF30246230, FEBRA20002100, FEBRA20034360, FEBRA20095140, FEBRA20130190, FEBRA20204060, HCHON20008320, LIVER20028420, TRACH20111130, ASTRO20108190, BRACE20003070, BRACE20060550, BRAWH20004600, BRAWH20011710, BRAWH20016620, BRHIP10001740, BRSTN10000830, CTONG10000940, CTONG20150910, D30ST10002670, FCBBF10000380, FCBBF10000770, FCBBF10003770, FCBBF20059090, FCBBF30016320, FCBBF30016570, FCBBF30049550, FCBBF30083820, FCBBF30238870, FCBBF40001420, FEBRA10001880, FEBRA20004620, FEBRA20080810, FEBRA20086620, FEBRA20095880, HHDPC20034390, HLUNG10000550, NT2RI20023160, NT2RI20023910, NT2RI20025400, NT2RI20028470, NT2RI20054050, NT2RI20076290, NT2RI20091730, NT2RI20091940, NT2RP70036880, NT2RP70078420, OCBBF20047570, OCBBF20080050, OCBBF20125530, OCBBF20140640, TRACH20032720, TRACH20141240, UTERU20004240
  • The result of comparative analysis of cDNA libraries derived from fetal heart (FEHRT) and adult heart (HEART) showed that the genes whose expression levels were different between the two were the following clones (Table 49).
  • FEHRT20003250, OCBBF20189560, BRAWH20029630, CTONG20150910, HCHON20007510, HEART20003060, HEART20005410, HEART20021840, HEART20025980, HEART20034320, HEART20037810, HEART20049400, HEART20049410, HEART20049800, HEART20061950, HEART20063340, HEART20067870, HEART20067890, HEART20072310, HEART20074430, HEART20077670, HEART20089940, HEART20090000, HEART20095990, HLUNG10000550, HLUNG20017120, KIDNE20028390, KIDNE20028830, NTONG20029480, OCBBF10001750, PROST20127800, SKMUS20001980, SKMUS20003610, SMINT20026890, SMINT20121220, SMINT20122910, SMINT20183530, SPLEN20008740, SPLEN20027440, SPLEN20162680, STOMA20062290, TESTI20254220, THYMU20271250, TRACH20141240, UTERU20004240
  • The result of comparative analysis of cDNA libraries derived from fetal kidney (FEKID) and adult kidney (KIDNE) showed that the genes whose expression levels were different between the two were the following clones (Table 50).
  • ASTRO10001650, ASTRO20108190, BGGI120006160, BRACE20039040, BRACE20060550, BRAMY20102080, BRAWH20004600, BRAWH20125380, BRAWH20162690, BRHIP20115760, BRHIP20205090, BRHIP20238880, CTONG20052650, CTONG20108210, CTONG20128470, CTONG20133480, CTONG20139070, D90ST20000310, DFNES20001530, FCBBF10001820, FEBRA20002100, HCHON20008980, HCHON20016650, HLUNG20033780, KIDNE20002520, KIDNE20003940, KIDNE20006780, KIDNE20007210, KIDNE20007770, KIDNE20008010, KIDNE20009470, KIDNE20011170, KIDNE20011400, KIDNE20013730, KIDNE20017130, KIDNE20018730, KIDNE20018970, KIDNE20020150, KIDNE20021680, KIDNE20021910, KIDNE20021980, KIDNE20022620, KIDNE20024830, KIDNE20027250, KIDNE20027950, KIDNE20028390, KIDNE20028830, KIDNE20029800, KIDNE20067330, KIDNE20079440, KIDNE20096280, KIDNE20096470, KIDNE20100070, KIDNE20100840, KIDNE20101370, KIDNE20101510, KIDNE20102650, KIDNE20102710, KIDNE20104300, KIDNE20106740, KIDNE20107390, KIDNE20107500, KIDNE20107620, KIDNE20109730, KIDNE20109890, KIDNE20112000, KIDNE20115080, KIDNE20118580, KIDNE20120090, KIDNE20121880, KIDNE20122910, KIDNE20124400, KIDNE20125630, KIDNE20126010, KIDNE20126130, KIDNE20127100, KIDNE20127450, KIDNE20127750, KIDNE20130450, KIDNE20131580, KIDNE20132180, KIDNE20137340, KIDNE20138010, KIDNE20141190, KIDNE20144890, KIDNE20148900, KIDNE20163880, KIDNE20180710, KIDNE20181660, KIDNE20182690, KIDNE20186780, KIDNE20190740, LIVER20035110, MESAN20025190, NOVAR20000380, NT2RI20054050, NT2RP70043480, PROST20107820, PROST20123530, PROST20161950, PUAEN20030180, SKMUS20003610, SMINT20033400, TBAES20000590, TESTI20044310, TESTI20082330, TRACH20032720, UTERU20099720, BRACE20003070, BRCOC20031870, CTONG20125640, FCBBF30016320, HCHON20002260, HLUNG10000550, PROST20130530, SPLEN20169720, SPLEN20194050, KIDNE20028720
  • The result of comparative analysis of cDNA libraries derived from fetal lung (FELNG) and adult lung (HLUNG) showed that the genes whose expression levels were different between the two were the following clones (Table 51).
  • BRACE20096200, BRAWH20004600, BRAWH20030250, BRCAN20006390, BRCAN20280360, BRHIP20238880, CTONG10000940, CTONG20103480, CTONG20129960, CTONG20155180, FCBBF10001210, FEBRA20144170, FEBRA20197110, HHDPC20034390, HLUNG20016330, HLUNG20016770, HLUNG20017120, HLUNG20023340, HLUNG20033780, HLUNG20084390, IMR3220002430, LIVER20028420, NOVAR20000380, NT2RI20054050, NT2RI20091730, NT2RP70044280, OCBBF20020830, OCBBF20125530, PLACE60004630, PROST20057930, PROST20107820, PROST20185830, PUAEN20030180, SMINT20121220, SPLEN20002220, SPLEN20054290, SPLEN20128000, SPLEN20157300, SPLEN20176200, SPLEN20179180, SPLEN20211940, STOMA20013890, TBAES20000590, TESTI20094230, TESTI20184620, TESTI20334410, THYMU20000570, THYMU20039810, TRACH20007020, TRACH20141240, TRACH20183170, D90ST20033970, FELNG20002410, HCHON20016650, KIDNE20029800, OCBBF20145760, SPLEN20162680, TESTI20214250, TRACH20005400, HCHON20002260, HLUNG10000550, NT2RI20023910, SPLEN20008740
  • These genes are involved in regeneration of tissues and/or cells.
    • EXAMPLE 8 Expression Frequency Analysis by PCR
  • Specific PCR primers were prepared based on the full-length nucleotide sequences, and the expression frequency was analyzed by the ATAC-PCR method (Adaptor-tagged competitive PCR method: Nucleic Acids Research 1997, 25(22): 4694-4696; “DNA Micro-array and Advanced PCR Techniques”, Cell Technology, supplement, Eds., Muramatsu and Nawa (Shujunsha, 2000): 104-112). Inflammation-related genes can be identified by revealing the genes whose expression levels are altered depending on the presence of an inflammation-inducing factor. Then, by using THP-1 cell line, which is a cell line of monocyte line, and TNF-α, which is inflammation-inducing factor, suitable for this system, the genes whose expression levels are altered depending on the presence of the factors were searched for by the system.
  • THP-1 cell line (purchased from DAINIPPON PHARMACEUTICAL) was cultured to be confluent in RPMI1640 medium (sigma) containing 5% fetal calf serum (GIBCO BRL). Then, the medium was changed with the medium containing 10 ng/ml TNF-α (human recombinant TNF-α; Pharmacia Biotech), and the culture was continued at 37° C. under 5% CO2. After three hours, the cells were harvested, and total RNA was extracted from them by using ISOGEN reagent (Nippon Gene). The extraction was carried out according to the method in the document attached to ISOGEN reagent. In addition, total RNA was also extracted from the cells cultured without stimulation of TNF-α.
  • The genes involved in the onset of gastritis and gastroduodenal ulcer induced by the infection of Helicobacter pylori to the epithelia of stomach can be identified by revealing the genes whose expression levels are altered depending on co-culturing the cells with Helicobacter pylori. A recent study has suggested that various substances derived from Helicobacter pylori trigger the inflammation reaction. In particular, the members belonging to the family of genes called “cag pathogenicity island (cag PAI)” contribute to the activation of the NF-KB pathway (Gastroenterology 2000, 119: 97-108). Further, it has been found that cag PAI is involved in the onset of gastritis and the like by the study using an animal model (Journal of Experimental Medicine 2000, 192:1601-1610). Then, by using co-culture of a gastric cancer cell line with cag PAI-positive Helicobacter pylori (TN2), suitable for this system, the genes whose expression levels are altered depending on the presence of Helicobacter pylori were searched for by the system. Further, in order to study the involvement of cag PAI in the alterations of gene expression levels depending on the co-culture with Helicobacter pylori, the altered expression levels were compared between the cells co-cultured with a strain of Helicobacter pylori (TN2ΔcagE strain) having a mutation in cagE, which is one of the cag PAI genes, and the cag PAI-positive strain (TN2).
  • A gastric cancer cell line MKN45 (provided by the Cell Bank, RIKEN GENE BANK, The Institute of Physical and Chemical Research) was cultured to be confluent in RPMI1640 medium (sigma) containing 10% fetal calf serum (GIBCO BRL). Then, the medium was changed with the medium containing 100-fold excess (in terms of the number of cells or the number of colonies) of Helicobacter pylori (cag PAI positive strain (TN2) and cagE mutant (TN2ΔcagE): both were provided by Prof. Omata, Faculty of Medicine, The University of Tokyo), as compared with the number of the cancer cells. The culture was continued at 37° C. under 5% CO2. After three hours, the cells were harvested, and total RNA was extracted from them by using ISOGEN reagent (Nippon Gene). The extraction was carried out according to the method in the document attached to ISOGEN reagent. In addition, total RNA was also extracted from the cells cultured without Helicobacter pylori.
  • The analysis by the ATAC-PCR method was carried out basically according to “DNA Micro-array and Advanced PCR Techniques”, Cell Technology, supplement (Genome Science Series 1, Eds., Muramatsu and Nawa (Shujunsha, 2000): 104-112). Adapter ligation to the internal standard sample (sample to make the calibration curve for the clone of interest) and test sample was carried out in the two separate reaction systems indicated below. The combination of 6 types of adapters (AD-1, AD-2, AD-3, AD-4, AD-5 and AD-6: see the sequences indicated below) and the samples are as follows.
  • Reaction System A
  • AD1; internal standard, 10-fold
  • AD2; THP-1 cells, unstimulated
  • AD3; internal standard, 3-fold
  • AD4; THP-1 cells, TNF-α stimulation for one hour
  • AD5; THP-1 cells, TNF-α stimulation for three hours
  • AD6; internal standard, 1-fold
  • Reaction system B
  • AD1; internal standard, 1-fold
  • AD2; MKN45 cells, unstimulated
  • AD3; internal standard, 3-fold
  • AD4; MKN45 cells, co-cultured with TN2(Helicobacter pylori)
  • AD5; internal standard, 10-fold
  • AD6; MKN45 cells, co-cultured with TN2AcagE(cagE gene mutant)
  • Adapter Sequences:
    SEQ ID NO: 4887//
    5′-GTACATATTGTCGTTAGAACGCG-3′
    SEQ ID NO: 4888//
    3′-CATGTATAACAGCAATCTTGCGCCTAG-5′
    AD2;
    SEQ ID NO: 4889//
    5′-GTACATATTGTCGTTAGAACGCGACT-3′
    SEQ ID NO: 4890//
    3′-CATGTATAACAGCAATCTTGCGCTGACTAG-5′
    AD3;
    SEQ ID NO: 4891//
    5′-GTACATATTGTCGTTAGAACGCGCATACT-3′
    SEQ ID NO: 4892//
    3′-CATGTATAACAGCAATCTTGCGCGTATGACTAG-5′
    AD4;
    SEQ ID NO: 4893//
    5′-GTACATATTGTCGTTAGAACGCGATCCATACT-3′
    SEQ ID NO: 4894//
    3′-CATGTATAACAGCAATCTTGCGCTAGGTATGACTAG-5′
    AD5;
    SEQ ID NO: 4895//
    5′-GTACATATTGTCGTTAGAACGCGTCAATCCATACT-3′
    SEQ ID NO: 4896//
    3′-CATGTATAACAGCAATCTTGCGCAGTTAGGTATGACTAG-5′
    AD6;
    SEQ ID NO: 4897//
    5′-GTACATATTGTCGTTAGAACGCGTACTCAATCCATACT-3′
    SEQ ID NO: 4898//
    3′-CATGTATAACAGCAATCTTGCGCATGAGTTAGGTATGACTAG-5′
  • The internal standard sample used for this assay was a mixture of total RNAs from tissues (or culture cells; all from UNITECH) of Fetal Brain, Testis, Trachea, and Spleen. RNA was prepared according to the standard method.
  • The sequences of primers specific to the genes and the names of clones of interest in the analysis are as follows. The gene specific primers were designed to produce the PCR products of 70 to 200 bp, which are derived from the adapter-containing cDNA. The sequence of adapter-specific primer (labeled with fluorescence (FAM)) used in the competitive PCR was GTACATATTGTCGTTAGAACGC (22 nucleotides; SEQ ID NO: 4899). PCR was basically carried out with a cycling profile of preheating at 94° C. for 3 minutes, and 35 or 40 cycles of denaturation at 94° C. for 30 seconds/annealing at 50° C. for 60 seconds/extension at 72° C. for 90 seconds.
  • The nucleotide sequences of clone specific primers used in the experiments
  • Clone name, primer sequence and SEQ ID NO are indicated below in this order. Each is demarcated by a double slash mark (//). For a clone for which a primer used in Reaction system A (THP-1 cells) was different from a primer used in Reaction system B (MKN45 cells), the sequence of each of the primers was shown.
    3NB6920014080// SEQ ID NO: 4900
    GTCCTGAAGGTAGATGCT//
    ADRGL20013010// SEQ ID NO: 4901
    GGAGGATAGAGCTTGGAG//
    ADRGL20067670// SEQ ID NO: 4902
    ATAAAACAGGACCAAGGA//
    ADRGL20083310// SEQ ID NO: 4903
    AAATAAGGCTAAAATGGAACT//
    ASTRO20032120// SEQ ID NO: 4904
    AGTGCTCCCAATTATCCG//
    ASTRO20084250// SEQ ID NO: 4905
    TAGAAAATATGCTGGGTG//
    ASTRO20152140// SEQ ID NO: 4906
    TCATTCTTCTCCCACAGC//
    ASTRO20166810// SEQ ID NO: 4907
    AGTTTTATTTCCAGGCTATC//
    ASTRO20181690// SEQ ID NO: 4908
    ATGGAGAACAGGACAGCT//
    BLADE20004630// SEQ ID NO: 4909
    CAAACATCAACCAGAGAA//
    BRACE20006400// SEQ ID NO: 4910
    TCCCAATCAGCTAAGGTC//
    BRACE20019540// SEQ ID NO: 4911
    CAGGTTATCGAGAGTTACAT//
    BRACE20038480// SEQ ID NO: 4912
    TCTGGTTGGATTTTGTGC//
    BRACE20039040// SEQ ID NO: 4913
    TGAACTTTGTGGTCTGGT//
    BRACE20039440// SEQ ID NO: 4914
    TGAACAGTGACATTTTAGG//
    BRACE20052160// SEQ ID NO: 4915
    AAGAATAAAAGGGACGAG//
    BRACE20053630// SEQ ID NO: 4916
    GTTTGATACAGATGATTAGGTTA//
    BRACE20057620// SEQ ID NO: 4917
    GGACAGGTAAGAACTAGGC//
    BRACE20058810// SEQ ID NO: 4918
    ATCATCTTTCCAATCCAG//
    BRACE20060720// SEQ ID NO: 4919
    GTACCACCTGACCTTCTG//
    BRACE20060840// SEQ ID NO: 4920
    AGAAGTTTTATCCCACATTT//
    BRACE20061740// SEQ ID NO: 4921
    (Reaction system A)//
    TAACATAACCCTCCCGTC//
    //(Reaction system B)// SEQ ID NO: 4922
    ATAGTGGTGACGTTCCCC//
    BRACE20062640// SEQ ID NO: 4923
    TCTGTTGCTGAAGGAAAA//
    BRACE20063780// SEQ ID NO: 4924
    TCCTGTGTGCTATTTGAA//
    BRACE20067430// SEQ ID NO: 4925
    AATAACAGCAACTCCAGA//
    BRACE20090440// SEQ ID NO: 4926
    CCCAACATTACCAAAAGT//
    BRACE20101700// SEQ ID NO: 4927
    CAACATTTTCAAGCACTG//
    BRACE20114780// SEQ ID NO: 4928
    GATGTTGGGGTTTGGAAG//
    BRACE20151320// SEQ ID NO: 4929
    ACCAGCTGCCCATAGAAG//
    BRACE20152870// SEQ ID NO: 4930
    GAAGGCAAGATGGTAAGT//
    BRACE20163150// SEQ ID NO: 4931
    CATAGAGAAAGCGGGGAA//
    BRACE20165830// SEQ ID NO: 4932
    (Reaction system A)//
    TCTCCCTGTTCTCTCTTT//
    //(Reaction system B)// SEQ ID NO: 4933
    TATGACCCAAACGCCTAG//
    BRACE20201570// SEQ ID NO: 4934
    CCTTCTCATCTAGCTTGC//
    BRACE20210140// SEQ ID NO: 4935
    TACTGATTGGGAAGCACT//
    BRACE20223330// SEQ ID NO: 4936
    GTTGAAATGCTTGAGCAC//
    BRACE20224500// SEQ ID NO: 4937
    ATTTAGAGCGCCATCCTT//
    BRACE20229280// SEQ ID NO: 4938
    CTGAGGGTAAAGGAAGGG//
    BRACE20235400// SEQ ID NO: 4939
    TTTTACGATTGCCTTTGC//
    BRACE20266750// SEQ ID NO: 4940
    TTAGGAGTGAAGACAGGA//
    BRACE20267250// SEQ ID NO: 4941
    GTGCAGTGATAAGTGGCT//
    BRACE20269710// SEQ ID NO: 4942
    AGGCAGGGAAAGTAGGGT//
    BRALZ20018340// SEQ ID NO: 4943
    AGGAGAGGCTTGAGGACT//
    BRALZ20058880// SEQ ID NO: 4944
    AAGGGACCAAAATGAGAG//
    BRALZ20059500// SEQ ID NO: 4945
    AACAGCCCTCTAATGAAA//
    BRALZ20064740// SEQ ID NO: 4946
    ACTCATGTTGCTCCACCT//
    BRALZ20069760// SEQ ID NO: 4947
    TATGTATGGCTTTGAGCA//
    BRALZ20075450// SEQ ID NO: 4948
    GCTGAAGAAATGTGCTGC//
    BRALZ20088690// SEQ ID NO: 4949
    ATCATAGTTGTACATACTTTGGC//
    BRAMY20002770// SEQ ID NO: 4950
    TTCTTTCCTGTAATAGTTGG//
    BRAMY20004110// SEQ ID NO: 4951
    AGCTATCTGTGAAAGTCCT//
    BRAMY20060920// SEQ ID NO: 4952
    (Reaction system A)//
    TGCTGTCTCGTGATAAAG//
    //(Reaction system B)// SEQ ID NO: 4953
    TTTCTAATGGTTTGGCAC//
    BRAM20103570// SEQ ID NO: 4954
    (Reaction system A)//
    TCAACAGTGCTTTTCCTT//
    //(Reaction system B)// SEQ ID NO: 4955
    GACTCTTCTCCAGGGTGC//
    BRAMY20144620// SEQ ID NO: 4956
    CACGCCATTCTGTTAAAA//
    BRAMY20152110// SEQ ID NO: 4957
    AATGGGCTAAATATTGCT//
    BRAMY20162510// SEQ ID NO: 4958
    GCAAATACAGGTAAATGACAG//
    BRAMY20163250// SEQ ID NO: 4959
    CAAGAGAAATTAAAGAAGACC//
    BRAMY20163270// SEQ ID NO: 4960
    (Reaction system A)//
    TGCTTTCAACTGTCATTT//
    //(Reaction system B)// SEQ ID NO: 4961
    GAATGATGCCCGATGTAG//
    BRAMY20168920// SEQ ID NO: 4962
    GAATATCCCTGTGGAGTC//
    BRAMY20178640// SEQ ID NO: 4963
    AGTCTCACTCTATTGCCA//
    BRAMY20184670// SEQ ID NO: 4964
    AACGAATAGCAGGGTAGC//
    BRAMY20204450// SEQ ID NO: 4965
    GGTGACTTACTGGCTGCA//
    BRAMY20210400// SEQ ID NO: 4966
    AAGATTAACCATACAACAGAAA//
    BRAMY20215230// SEQ ID NO: 4967
    TGAACAAGAAACACCAGT//
    BRAMY20218670// SEQ ID NO: 4968
    AGGAGGCACGGTAACAAT//
    BRAMY20229800// SEQ ID NO: 4969
    GTCTTCTGTCTCATGGGG//
    BRAMY20229840// SEQ ID NO: 4970
    AAAGTTCATGAGGGGCTG//
    BRAMY20231720// SEQ ID NO: 4971
    CAGCACAAAATCAGTTAAA//
    BRAMY20247280// SEQ ID NO: 4972
    GGTTTAGATTTATGAGACAAGA//
    BRAMY20261680// SEQ ID NO: 4973
    GTTACTGCAGGGCTTCAG//
    BRAMY20266850// SEQ ID NO: 4974
    TGCATGGAATTAAGGAGT//
    BRAMY20267130// SEQ ID NO: 4975
    AATCTGTAAAATGGGAATAAG//
    BRAMY20277140// SEQ ID NO: 4976
    (Reaction system A)//
    ATGAGATTGTGTTGTCCA//
    //(Reaction system B)// SEQ ID NO: 4977
    TTCCAGCATTTTCGTTTT//
    BRAMY20280720// SEQ ID NO: 4978
    (Reaction system A)//
    TTCCCAAGTCCAGATTTT//
    //(Reaction system B)// SEQ ID NO: 4979
    CTGAGGAGCAGTGACAAG//
    BRAWH10000930// SEQ ID NO: 4980
    GGGAGAGAAGAGTCCTGC//
    BRAWH20015350// SEQ ID NO: 4981
    GCTATGAAGACAACCAAACT//
    BRAWH20017010// SEQ ID NO: 4982
    AGGAAGACATGGGTCAGC//
    BRAWH20029630// SEQ ID NO: 4983
    GGAGTATCACCATGTAAAGA//
    BRAWH20100690// SEQ ID NO: 4984
    (Reaction system A)//
    AAATGAGCACTCCATTCC//
    //(Reaction system B)// SEQ ID NO: 4985
    AATGAGCACTCCATTCCC//
    BRAWH20106180// SEQ ID NO: 4986
    (Reaction system A)//
    CATTTTATTGTCACCCAC//
    //(Reaction system B)// SEQ ID NO: 4987
    CCTTTAACAGCATCTCTAGTG//
    BRAWH20107540// SEQ ID NO: 4988
    GTTGAGCTATTTGCAGAG//
    BRAWH20110660// SEQ ID NO: 4989
    CTTAGCAACTTTCCACAC//
    BRAWH20118230// SEQ ID NO: 4990
    GTCAGAAAACTCACACCA//
    BRAWH20122770// SEQ ID NO: 4991
    AAGTTGATAGGGAAGGTTT//
    BRAWH20126190// SEQ ID NO: 4992
    ACCATGTGCTCAGAATCA//
    BRAWH20132190// SEQ ID NO: 4993
    TAAGATTCACACGGTGGA//
    BRAWH20138660// SEQ ID NO: 4994
    GATGGAAAATGTAAGGCT//
    BRAWH20139410// SEQ ID NO: 4995
    CCATCCTCTACACAGCAG//
    BRAWH20155950// SEQ ID NO: 4996
    (Reaction system A)//
    CTCTCATTTTGGCTCTGC//
    //(Reaction system B)// SEQ ID NO: 4997
    CTACTCCACCTCTGCTGC//
    BRAWH20158530// SEQ ID NO: 4998
    AGTTTTCTGATGGCCTTG//
    BRCAN20060190// SEQ ID NO: 4999
    AGGTAGCCCCAGAGTCAC//
    BRCAN20147880// SEQ ID NO: 5000
    ACTCAGCAATCAGGTCCA//
    BRCAN20273340// SEQ ID NO: 5001
    AATTATGAGATAGGATGTTAGCT//
    BRCAN20273640// SEQ ID NO: 5002
    CTGCACCGATTTTATAGC//
    BRCAN20275130// SEQ ID NO: 5003
    CACTATCCAGACACACCT//
    BRCAN20280210// SEQ ID NO: 5004
    CACTGGATTTTCTTCACTT//
    BRCAN20280400// SEQ ID NO: 5005
    GGAAGGATAGCAGTTGAT//
    BRCOC20021550// SEQ ID NO: 5006
    TCCAAGCAGAGTTTTCAC//
    BRCOC20037400// SEQ ID NO: 5007
    CAAGTCTGTTCATCTGGT//
    BRCOC20105100// SEQ ID NO: 5008
    (Reaction system A)//
    ACTTGAGGTTTCTTGGCA//
    //(Reaction system B)// SEQ ID NO: 5009
    GATTCTTCCCCGACTCAG//
    BRHIP10001740// SEQ ID NO: 5010
    GTACACACCTGCTCCCAC//
    BRHIP20001630// SEQ ID NO: 5011
    GGTCAGTAAGTGGTTGTG//
    BRHIP20096170// SEQ ID NO: 5012
    TTATTTTGGATGCCCCTG//
    BRHIP20103090// SEQ ID NO: 5013
    ACTCCAACAACCTTCATT//
    BRHIP20105710// SEQ ID NO: 5014
    TTTCAAGTATCCTCCCCA//
    BRHIP20110800// SEQ ID NO: 5015
    TAGAACTGCCTCCAACCC//
    BRHIP20111200// SEQ ID NO: 5016
    TACTGAACGGTGACTGGC//
    BRHIP20118910// SEQ ID NO: 5017
    ACAGGAAGGGGAAAGAGT//
    BRHIP20129720// SEQ ID NO: 5018
    GAGGAGAGTGAGAAGGGG//
    BRHIP20143860// SEQ ID NO: 5019
    AGGTCAGGAGAACAAGCC//
    BRHIP20173150// SEQ ID NO: 5020
    CTTTTGCAGAGTTTTCCT//
    BRHIP20175420// SEQ ID NO: 5021
    TCTCTAGGGCAAAACATT//
    BRHIP20186120// SEQ ID NO 5022
    (Reaction system A)//
    AATTGATACGCAGGGGAG//
    //(Reaction system B)// SEQ ID NO: 5023
    AAGGTCAGTTGAAGTGCT//
    BRHIP20194940// SEQ ID NO: 5024
    TAGAGAAGGTGAGGCCAG//
    BRHIP20196410// SEQ ID NO: 5025
    GGCATAGAAGTAATCAGAGA//
    BRHIP20207430// SEQ ID NO: 5026
    AAGCTGAACCCCAATAAA//
    BRHIP20218580// SEQ ID NO: 5027
    GATTACCAGAACACAGCC//
    BRHIP20233090// SEQ ID NO: 5028
    GTCCATTTACCAACCGCT//
    BRHIP20284800// SEQ ID NO: 5029
    CACATCTTTACATTTATTGCTATT//
    BRHIP30004880// SEQ ID NO: 5030
    TCTTCTCGTAGGGCTTGA//
    BRSSN20046570// SEQ ID NO: 5031
    AAACACGAAATGGATGAA//
    BRSSN20142940// SEQ ID NO: 5032
    AGAATCAGAGAAGCCGGT//
    BRSSN20152380// SEQ ID NO: 5033
    ATACCCATTTCAGTTCCT//
    BRSSN20176820// SEQ ID NO: 5034
    CAGTCCCAATACAGCTCA//
    BRSSN20187310// SEQ ID NO: 5035
    (Reaction system A)//
    CAATGACTAGTTTGTGCA//
    //(Reaction system B)// SEQ ID NO: 5036
    AAAGAAGCCAGGAAGATT//
    BRTHA20046390// SEQ ID NO: 5037
    ACATGGAGCCTGGTTTAG//
    CD34C30004240// SEQ ID NO: 5038
    TGGAAGATACGGATAACTC//
    CD34C30004940// SEQ ID NO: 5039
    (Reaction system A)//
    ACCACTGTTCTCTGGTGC//
    //(Reaction system B)// SEQ ID NO: 5040
    CCACCACTGTTCTCTGGT//
    COLON20043180// SEQ ID NO: 5041
    TCGGATTGGGTTAAGGTC//
    CTONG10000620// SEQ ID NO: 5042
    CTCCATTCATCAGACCAC//
    CTONG20014280// SEQ ID NO: 5043
    TCCAAAAGACAGAACAGC//
    CTONG20095270// SEQ ID NO: 5044
    GTTTTGTTCCCTGCTCAC//
    CTONG20095290// SEQ ID NO: 5045
    AACACAGCTCAACAACTC//
    CTONG20096750// SEQ ID NO: 5046
    TGACTAAGCATGGAGACT//
    CTONG20100240// SEQ ID NO: 5047
    AGTCATAATCATCTTCCTCA//
    CTONG20103480// SEQ ID NO: 5048
    GGTGGAGTAATGTATATAACGTAA//
    CTONG20105660// SEQ ID NO: 5049
    CCATTAACACAAACCAAA//
    CTONG20121010// SEQ ID NO: 5050
    GGAAGATGGGACCTCAGT//
    CTONG20128470// SEQ ID NO: 5051
    TTGGGGTATCTTGGAGCT//
    CTONG20138030// SEQ ID NO: 5052
    GGCATAGAAGTAATCAGAGA//
    CTONG20139070// SEQ ID NO: 5053
    TCAAACCTCCTATCTTCTG//
    CTONG20146970// SEQ ID NO: 5054
    TTTTAATCCTCAGTACATTTTC//
    CTONG20158150// SEQ ID NO: 5055
    AAATAGGTTGATGTTGGC//
    CTONG20186320// SEQ ID NO: 5056
    TGACTTTGGCCCTTTACC//
    CTONG20265130// SEQ ID NO: 5057
    GGGTAGGTGCTAGAAATC//
    D3OST20006540// SEQ ID NO: 5058
    GGAGACCACACATAACAT//
    D3OST20037970// SEQ ID NO: 5059
    CACTGACGAAAGGGAAGA//
    D9OST20031370// SEQ ID NO: 5060
    CGACTTGCCAGACTCACT//
    DFNES10001850// SEQ ID NO: 5061
    GTGGCTCAAAGTAGGATT//
    DFNES20031920// SEQ ID NO: 5062
    CTTACTCCAACCCAGGCT//
    FCBBF10005060// SEQ ID NO: 5063
    TGCATGTTTTCTTCCTCA//
    FCBBF20032970// SEQ ID NO: 5064
    CCAGACACAACAATACCA//
    FCBBF20035280// SEQ ID NO: 5065
    (Reaction system A)//
    ATACAATTTGTGCCTGTTA//
    //(Reaction system B)// SEQ ID NO: 5066
    CGGTAAGTAGTCTTCATGTG//
    FCBBF20054280// SEQ ID NO: 5067
    GGTGCATCTGTACTTGAA//
    FCBBF20071860// SEQ ID NO: 5068
    TGGAGGAGTAGTTATCAGTTG//
    FCBBF30001840// SEQ ID NO: 5069
    AGTGCTCCCAATTATCCG//
    FCBBF30016320// SEQ ID NO: 5070
    GGCTACTCAAGGACACAG//
    FCBBF30016570// SEQ ID NO: 5071
    AGGGATAAGATGGCAGGT//
    FCBBF30033050// SEQ ID NO: 5072
    TCCTGTACTCCTTTCCAT//
    FCBBF30071520// SEQ ID NO: 5073
    CAGGCATAAGAGGTGGCT//
    FCBBF30083820// SEQ ID NO: 5074
    CCTGTGTGATACCAAATACT//
    FCBBF30215060// SEQ ID NO: 5075
    CAGCCCCAATTACTAGAA//
    FCBBF30251420// SEQ ID NO: 5076
    AGCATGTACTGGGAAAGC//
    FCBBF30252520// SEQ ID NO: 5077
    AGGGATAAAGAATGCAAA//
    FCBBF30262360// SEQ ID NO: 5078
    GAGCTTCAGGGGCATTTA//
    FCBBF30266920// SEQ ID NO: 5079
    ATACGCAATTTTCAGACC//
    FCBBF30278630// SEQ ID NO: 5080
    AAAAGACAACGATGCCTG//
    FCBBF30285280// SEQ ID NO: 5081
    AAAGCAAAGTGATATAGGAGT//
    FCBBF40001420// SEQ ID NO: 5082
    ACATTTCAGTCCATTCAC//
    FEBRA10001880// SEQ ID NO: 5083
    TTGTCATGGTGGTAATCC//
    FEBRA20010120// SEQ ID NO: 5084
    GGACCAGACTCACAAATT//
    FEBRA20017050// SEQ ID NO: 5085
    TATACTAAAACCCAGCCA//
    FEBRA20034360// SEQ ID NO: 5086
    CGGCAGCTAGAAAACCTC//
    FEBRA20037260// SEQ ID NO: 5087
    CGTTGGTTTTCTGGACAC//
    FEBRA20037500// SEQ ID NO: 5088
    CTCGGGCAGGATTAACTC//
    FEBRA20082100// SEQ ID NO: 5089
    AGAAGATGCTAGGTTTGC//
    FEBRA20095880// SEQ ID NO: 5090
    AGCATGTACTGGGAAAGC//
    FEBRA20167390// SEQ ID NO: 5091
    GCTTATGTTGCAGTTTCA//
    FEBRA20176800// SEQ ID NO: 5092
    TCAGTTTCAGGGGTCAAG//
    FEBRA20226010// SEQ ID NO: 5093
    TCAGGGTATCAGCTTTCC//
    HCASM10000500// SEQ ID NO: 5094
    TGTGGTGACTTACTGCCT//
    HCHON20002260// SEQ ID NO: 5095
    CTCTCCAACAAACTGCAC//
    HCHON20008980// SEQ ID NO: 5096
    CTGCTGCCTTACACAACC//
    HCHON20009350// SEQ ID NO: 5097
    AGGTAATGAGGAATGCAC//
    HCHON20010990// SEQ ID NO: 5098
    GATTCCACCCTCAAGATT//
    HCHON20011160// SEQ ID NO: 5099
    CTCCTCCACGCTTGTTTT//
    HCHON20015230// SEQ ID NO: 5100
    CTTGGTCACAGTTTTCAT//
    HCHON20022470// SEQ ID NO: 5101
    CACACTTTCAATCCGAGG//
    HCHON20035130// SEQ ID NO: 5102
    GTGGAAGATGCTCGACTG//
    HCHON20043590// SEQ ID NO: 5103
    AGGATTAGGTATTGCTTCTC//
    HCHON20067220// SEQ ID NO: 5104
    TAAGGAAAACCCAACCAC//
    HCHON20076500// SEQ ID NO: 5105
    GAAAGACACCTGGCACAC//
    HEART20021840// SEQ ID NO: 5106
    GTACCCCAAAAGAAACAT//
    HEART20067870// SEQ ID NO: 5107
    GAACTATCTAATCACATGGG//
    HEART20083640// SEQ ID NO: 5108
    (Reaction system A)//
    TCTTGATGTCTCCTGCCT//
    //(Reaction system B)// SEQ ID NO: 5109
    CTCGGCTGGAAGGTAAAA//
    HHDPC10000650// SEQ ID NO: 5110
    ACTGGTAAGATATGGGCA//
    HHDPC20034390// SEQ ID NO: 5111
    CTCTCCCAAACTCAGGTC//
    HHDPC20095280// SEQ ID NO: 5112
    TGACCCAAAGACATACTG//
    HLUNG10000550// SEQ ID NO: 5113
    GATTTACTTCCGGTTTCG//
    KIDNE20018970// SEQ ID NO: 5114
    AAGAGAATAAGGCTGGGC//
    KIDNE20028720// SEQ ID NO: 5115
    AACAAAATAAGGGGCCAG//
    KIDNE20079440// SEQ ID NO: 5116
    AAGTTCATCTGGGTGTGG//
    KIDNE20096470// SEQ ID NO: 5117
    ATCACCTGGAGAGCTTTG//
    KIDNE20106740// SEQ ID NO: 5118
    AGGGACACTGAGAACTGG//
    KIDNE20120090// SEQ ID NO: 5119
    GAAGCAGGGAAGTGTGAG//
    KIDNE20127750// SEQ ID NO: 5120
    GCTATTACACATTCTGCATT//
    KIDNE20130450// SEQ ID NO: 5121
    CAGCTACTTGGGACAGGA//
    KIDNE20132180// SEQ ID NO: 5122
    (Reaction system A)//
    ACCAGCTCAGCAAGAACT//
    //(Reaction system B)// SEQ ID NO: 5123
    CTCTGACATGAACTGGTG//
    KIDNE20141190// SEQ ID NO: 5124
    CACATTGCCTAGAGAAAG//
    KIDNE20148900// SEQ ID NO: 5125
    ACAACAGCAGATGACTCG//
    KIDNE20163880// SEQ ID NO: 5126
    CAGTCACATCTCCCTTTA//
    KIDNE20182690// SEQ ID NO: 5127
    TCACTGTATCACCATCTG//
    LIVER10004790// SEQ ID NO: 5128
    TCCCTGCTAAGATGTTGA//
    LIVER20011130// SEQ ID NO: 5129
    GAGGTCAAGGACACACAG//
    LIVER20038540// SEQ ID NO: 5130
    (Reaction system A)//
    AAGCAATGTGGCAGACTC//
    //(Reaction system B)// SEQ ID NO: 5131
    AGTGGGTTCTTTATCATTTT//
    LIVER20055440// SEQ ID NO: 5132
    GTTTGCCAGGGAATGTTT//
    LIVER20062510// SEQ ID NO: 5133
    GTAACGTGCTCTGAATGA//
    LIVER20085800// SEQ ID NO: 5134
    GCTCTGCTGTTTCTAATTT//
    MAMGL10000830// SEQ ID NO: 5135
    TCGATACGTGGAAGAATT//
    MESAN20031900// SEQ ID NO: 5136
    TCCCAAGGCTGTAGTTCA//
    MESAN20121130// SEQ ID NO: 5137
    AGCTTGTATCTAAATTCGTG//
    MESAN20127350// SEQ ID NO: 5138
    CAGAAGACAGGTTGCCAG//
    MESAN20130220// SEQ ID NO: 5139
    CCTAAGATTGGTCGTCCT//
    MESAN20154010// SEQ ID NO: 5140
    ATCCTGTCATCTTTTCGC//
    MESAN20174170// SEQ ID NO: 5141
    TGGCTAAGGTTCTCAGGA//
    NOVAR10001020// SEQ ID NO: 5142
    GGGTCAGTAAATCTAATGC//
    NT2NE20053580// SEQ ID NO: 5143
    CAAAACACAGAGTTATCAGAA//
    NT2NE20089610// SEQ ID NO: 5144
    TGCTGTCCTAGAAGAATAAA//
    NT2NE20089970// SEQ ID NO: 5145
    ACAATTATACTGGAAAAGCA//
    NT2NE20146810// SEQ ID NO: 5146
    GCTGAGACCTTTTGCTAG//
    NT2NE20155110// SEQ ID NO: 5147
    AGCCGAGGTTTTGAGTTA//
    NT2NE20156260// SEQ ID NO: 5148
    ACATTTGCACTGGAACTG//
    NT2NE20158600// SEQ ID NO: 5149
    CTCAGAAGCCCAGCAATT//
    NT2NE20172590// SEQ ID NO: 5150
    ACATCATAATCAAGCAGTAAA//
    NT2NE20174920// SEQ ID NO: 5151
    AGGACAGCAACAAGAGAG//
    NT2NE20181650// SEQ ID NO: 5152
    AGAGCTGATTTATACGCA//
    NT2RI20005750// SEQ ID NO: 5153
    AAGGAGTCTACGAAGCAC//
    NT2RI20009870// SEQ ID NO: 5154
    AAGATGACCCCGAGTTTG//
    NT2RI20023160// SEQ ID NO: 5155
    CATGCAAATAGAGGACTG//
    NT2RI20040930// SEQ ID NO: 5156
    CCATACTGTTCTCTGCTG//
    NT2RI20046080// SEQ ID NO: 5157
    CCGTAACTTTTATATGCCTG//
    NT2RI20055790// SEQ ID NO: 5158
    GCAAGAGCTACAGACAAA//
    NT2RI20069730// SEQ ID NO: 5159
    AGTGTGCAGAAATCCGTG//
    NT2RI20203900// SEQ ID NO: 5160
    AGCAGTAGCACAGCCTTA//
    NT2RP70062230// SEQ ID NO: 5161
    (Reaction system A)//
    ACTCTAACACATTTGGCA//
    //(Reaction system B)// SEQ ID NO: 5162
    TATTAGTGTCAGCTGGCA//
    NT2RP70102350// SEQ ID NO: 5163
    (Reaction system A)//
    ATAGGAGGTGTCATGCCC//
    //(Reaction system B)// SEQ ID NO: 5164
    TCTTTTGACCTACACTGC//
    NT2RP70110860// SEQ ID NO: 5165
    GGGGAAGGGAGTAAGGTC//
    NT2RP70111320// SEQ ID NO: 5166
    ACTTAGCATCCAGACCTC//
    NT2RP70130020// SEQ ID NO: 5167
    ATACTCTCTGCTCATGGA//
    NT2RP70143480// SEQ ID NO: 5168
    TTCTTGGCATCCTTCATT//
    NT2RP70150800// SEQ ID NO: 5169
    (Reaction system A)//
    GAGGCTTGTCTAGGGGAA//
    //(Reaction system B)// SEQ ID NO: 5170
    GAACAAGGGATGCAGGAT//
    NT2RP70157890// SEQ ID NO: 5171
    (Reaction system A)//
    TATGTGATGTTTTCCCCA//
    //(Reaction system B)// SEQ ID NO: 5172
    CTGCCTAAATAACACTGAAG//
    NT2RP70169110// SEQ ID NO: 5173
    CTGTCCTCATCTGTGCAT//
    NT2RP70175670// SEQ ID NO: 5174
    GGTAGAACGGGAAATCAT//
    NT2RP70188020// SEQ ID NO: 5175
    AGGTTTGAGTAGAGGGAA//
    NT2RP70188710// SEQ ID NO: 5176
    ATACAGCAGGGAAGAGGC//
    NT2RP70190640// SEQ ID NO: 5177
    CAATGTGTCTTCAGTTTCC//
    NTONG20029480// SEQ ID NO: 5178
    TCTTGATGTCTCCTGCCT//
    NTONG20064840// SEQ ID NO: 5179
    AAAGCCATCGTACACCAT//
    NTONG20067090// SEQ ID NO: 5180
    AATTCTTTAGCTCTGTTGC//
    NTONG20070340// SEQ ID NO: 5181
    ATCCACTGCCCCTTATCA//
    NTONG20077560// SEQ ID NO: 5182
    CTGCTAGAATACGCCTTA//
    NTONG20083650// SEQ ID NO: 5183
    CTCATAGTTCAAGGCAGC//
    NTONG20090680// SEQ ID NO: 5184
    GAGTAAGGTCGTAGTCAGTG//
    OCBBF20005230// SEQ ID NO: 5185
    GCAAGACCTACAGACAAA//
    OCBBF20019380// SEQ ID NO: 5186
    GTGGTCAGTGGAAAATGG//
    OCBBF20020150// SEQ ID NO: 5187
    GGGACAGTATGGCAGAGA//
    OCBBF20020830// SEQ ID NO: 5188
    GCTTGCCATAGGTGTACT//
    OCBBF20039250// SEQ ID NO: 5189
    TTTCAGCAGTTAAGTGTTTT//
    OCBBF20041680// SEQ ID NO: 5190
    TCAGAAGGTATGCCCACT//
    OCBBF20047570// SEQ ID NO: 5191
    ACCCTTATGTCAAACTGC//
    OCBBF20051610// SEQ ID NO: 5192
    TTTTCCTACCTGCAATGG//
    OCBBF20054200// SEQ ID NO: 5193
    GTCACAAGCCATACGTGC//
    OCBBF20061720// SEQ ID NO: 5194
    CAAAGTGGCCTAAACCCT//
    OCBBF20062140// SEQ ID NO: 5195
    CTGGGGAGATAAGAGCCT//
    OCBBF20071960// SEQ ID NO: 5196
    (Reaction system A)//
    CTCAGTCACGCAATAGAT//
    //(Reaction system B)// SEQ ID NO: 5197
    TCTCTGGAAGGGAAAATT//
    OCBBF20072320// SEQ ID NO: 5198
    AAGAAGGAATGGGCACAC//
    OCBBF20079310// SEQ ID NO: 5199
    CAGTAGCAAAACCAGAGC//
    OCBBF20081380// SEQ ID NO: 5200
    GTGGAAGTGCCTGATGAG//
    OCBBF20085200// SEQ ID NO: 5201
    TACAGGGTCAGTTGGCAG//
    OCBBF20094240// SEQ ID NO: 5202
    ACACAATTCATCACTGCT//
    OCBBF20107920// SEQ ID NO: 5203
    GGTTGCTGTGAGTGCATT//
    OCBBF20127040// SEQ ID NO: 5204
    TAGAGGAGGCAGTAAGGG//
    OCBBF20130110// SEQ ID NO: 5205
    AGTGTCTATGGCTCTTCC//
    OCBBF20139260// SEQ ID NO: 5206
    GGGTGGTTCTGTTAGGAG//
    OCBBF20164050// SEQ ID NO: 5207
    TGCTGGAAATAATCGCTT//
    OCBBF20178990// SEQ ID NO: 5208
    TGAGTGTGGTGAAGATAGT//
    OCBBF20180840// SEQ ID NO: 5209
    AGAAACCTGAACGATGTC//
    PEBLM10000240// SEQ ID NO: 5210
    ATTACGATGCTTTGTTCA//
    PEBLM20013120// SEQ ID NO: 5211
    TAAAATTCTTGTGGTTGG//
    PEBLM20024550// SEQ ID NO: 5212
    TTGTGCCCTTAGAAAATC//
    PEBLM20052820// SEQ ID NO: 5213
    CCTGATAACCATGAATTG//
    PEBLM20074370// SEQ ID NO: 5214
    AGCATTTGGTTTTATACTGTTA//
    PERIC20002140// SEQ ID NO: 5215
    CGTTACCATCACAATTTCA//
    PERIC20004780// SEQ ID NO: 5216
    ACTTGAGCAGAGGAGAGC//
    PLACE60003480// SEQ ID NO: 5217
    ACTGGTATTTGCTGTGAA//
    PLACE60136720// SEQ ID NO: 5218
    AGGAACAGAGGCTACATC//
    PLACE60155130// SEQ ID NO: 5219
    GTCTAGCTGGGATGATGG//
    PLACE60169420// SEQ ID NO: 5220
    AAGACCCCGATAGAGAGC//
    PLACE60181070// SEQ ID NO: 5221
    CCTTCTTCAGTCTTGCAC//
    PROST10004800// SEQ ID NO: 5222
    AGTTTTGTTCACCCCTCC//
    PROST20120160// SEQ ID NO: 5223
    TAGAATGGTGGGAAGTGG//
    PROST20144220// SEQ ID NO: 5224
    TTAGTGGTCTGTTGATAGTTTT//
    PROST20149160// SEQ ID NO: 5225
    TTGGCCTTAGGTGAGTCC//
    PROST20149250// SEQ ID NO: 5226
    GGTACATAAGGAATCGCT//
    PROST20151240// SEQ ID NO: 5227
    (Reaction system A)//
    ACTCTCGCTTCCTGTCAC//
    //(Reaction system B)// SEQ ID NO: 5228
    GACGGACCCTTGACATTA//
    PROST20153320// SEQ ID NO: 5229
    ACTGTGGAGAAGGAGGGA//
    PROST20161950// SEQ ID NO: 5230
    ATTTGACGTATCCATGCC//
    PROST20189770// SEQ ID NO: 5231
    TGGTAAGTGGTGGAAGCT//
    PUAEN20003740// SEQ ID NO: 5232
    CCAAAACAATAATCCAACAT//
    PUAEN20011880// SEQ ID NO: 5233
    AGCCGTTGTCATCATAGA//
    PUAEN20015260// SEQ ID NO: 5234
    ATTGGAAGTCCCTATGAT//
    PUAEN20025680// SEQ ID NO: 5235
    CTCCTCTGAAGTAGCTGC//
    PUAEN20040670// SEQ ID NO: 5236
    AATGGTTCTCTGGCTTGG//
    PUAEN20045250// SEQ ID NO: 5237
    CAAAATGGTTAAACACAAA//
    PUAEN20078980// SEQ ID NO: 5238
    AGAAAGGCACACAATAAA//
    PUAEN20085150// SEQ ID NO: 5239
    AATTTAGGGGAACTGAGTAC//
    SKMUS20018230// SEQ ID NO: 5240
    TTCGCTCTTATCACCCAG//
    SKMUS20028210// SEQ ID NO: 5241
    ACTTCCCTTGGAATTGCT//
    SKMUS20031680// SEQ ID NO: 5242
    CAGAAGAACAGGAGGCAC//
    SKMUS20046670// SEQ ID NO: 5243
    GCAACGTCTTACTGTGAA//
    SKNSH20062340// SEQ ID NO: 5244
    GACATTGACGTATTCTAACTG//
    SKNSH20080430// SEQ ID NO: 5245
    TACCCTCCGCTGTGTTAG//
    SMINT20001760// SEQ ID NO: 5246
    CTCCTCCAGCTCTTGTCC//
    SMINT20013480// SEQ ID NO: 5247
    GGCACGTTTTAATATACCAC//
    SMINT20014580// SEQ ID NO: 5248
    CCCTCCAGACAGTTCAAA//
    SMINT20033400// SEQ ID NO: 5249
    CGATGGGTAGGACTTAAA//
    SMINT20047810// SEQ ID NO: 5250
    (Reaction system A)//
    CTCCTGACATTTCCTTTT//
    //(Reaction system B)// SEQ ID NO: 5251
    TAGGAAAAGAAGCAGGGC//
    SMINT20051610// SEQ ID NO: 5252
    AGTGAGGTTAGGGAAATATC//
    SMINT20056210// SEQ ID NO: 5253
    TATTCCTGTTTGATGGGG//
    SMINT20060780// SEQ ID NO: 5254
    TCTGTAATAGGGAGGTGTC//
    SMINT20080540// SEQ ID NO: 5255
    GAGGTACTTTTCAGACAGG//
    SMINT20105000// SEQ ID NO: 5256
    (Reaction system A)//
    AAAATGAGGTTCAGTCCC//
    //(Reaction system B)// SEQ ID NO: 5257
    TCACCTCCCCATTAACTG//
    SMINT20108530// SEQ ID NO: 5258
    CACCCTCGTTTTCTTTAG//
    SMINT20122850// SEQ ID NO: 5259
    AGCTAAATCCACTGAGGT//
    SMINT20122910// SEQ ID NO: 5260
    GGACAGACTTGCAGAGAA//
    SMINT20153530// SEQ ID NO: 5261
    GGGCCTAGAGTGGAAGTG//
    SMINT20161220// SEQ ID NO: 5262
    AGAACCAGTCCAAGCCAT//
    SMINT20163960// SEQ ID NO: 5263
    TTGATAAAATAGAGCCCA//
    SMINT20164770// SEQ ID NO: 5264
    AGTGTGCAGAAATCCGTG//
    SMINT20168570// SEQ ID NO: 5265
    (Reaction system A)//
    TGGTCCTCATGGTACAGC//
    //(Reaction system B)// SEQ ID NO: 5266
    ATGGCTGCTAGCTTGTCA//
    SPLEN20008820// SEQ ID NO: 5267
    CTGTCTGCCCTGAATCTT//
    SPLEN20011410// SEQ ID NO: 5268
    TTTTGGGACTGGAAGGAG//
    SPLEN20013540// SEQ ID NO: 5269
    TCACTCACACCAATCCTG//
    SPLEN20019450// SEQ ID NO: 5270
    TTCGTAAACATCTGGGCA//
    SPLEN20022230// SEQ ID NO: 5271
    AAGTTGCACCCAGACATC//
    SPLEN20040600// SEQ ID NO: 5272
    TCTTATTTCACAGTTTCCA//
    SPLEN20076530// SEQ ID NO: 5273
    CCCCACAGAACACTTACT//
    SPLEN20111190// SEQ ID NO: 5274
    AGACGTAGCAGCAACTCC//
    SPLEN20126190// SEQ ID NO: 5275
    TAGACCCAACCCTCACAC//
    SPLEN20152760// SEQ ID NO: 5276
    TGAGACGAATTGGTAAAA//
    SPLEN20157300// SEQ ID NO: 5277
    CTTGACATTTGCTCTCCA//
    SPLEN20158990// SEQ ID NO: 5278
    AAAACTGGGTCAAATAAAA//
    SPLEN20163560// SEQ ID NO: 5279
    TGCCCAGATAGAAAAGTG//
    SPLEN20174260// SEQ ID NO: 5280
    GGCCTTGTTGAATCTGAA//
    SPLEN20211570// SEQ ID NO: 5281
    CTCAACACAACTCCAAGC//
    SPLEN20214580// SEQ ID NO: 5282
    CCAAACGAATGTCAAGCT//
    SPLEN20245300// SEQ ID NO: 5283
    ATCTGCTCTTCATCCCTT//
    SPLEN20279950// SEQ ID NO: 5284
    CCTGTTCCTACACCGCAT//
    SPLEN20280660// SEQ ID NO: 5285
    GGCCAGACAGGAAGAGTT//
    SPLEN20283650// SEQ ID NO: 5286
    AAGTTGATGCTCCTGTTG//
    SPLEN20329240// SEQ ID NO: 5287
    (Reaction system A)//
    TAACACATGGACTGCTGG//
    //(Reaction system B)// SEQ ID NO: 5288
    AAGGTAGGAAATGCCAGC//
    STOMA20010250// SEQ ID NO: 5289
    TTTTGACCATAAGCTCCT//
    STOMA20032890// SEQ ID NO: 5290
    CGAGAAATAACTAATACACCTG//
    STOMA20048520// SEQ ID NO: 5291
    GAGGGTGAAGCAGGTAGG//
    STOMA20057820// SEQ ID NO: 5292
    GGCATTTCCCTTGTATATT//
    STOMA20062290// SEQ ID NO: 5293
    CCGTGTATTCAGCTCCCT//
    STOMA20076800// SEQ ID NO: 5294
    TAAACGGGAATCAGGAAG//
    TESTI20001170// SEQ ID NO: 5295
    TTTCAGACATATCAAGTTCA//
    TESTI20002780// SEQ ID NO: 5296
    ATTCCAGCCATACGGTTA//
    TESTI20004890// SEQ ID NO: 5297
    AAAACCACAGGAAGAAAG//
    TESTI20011200// SEQ ID NO: 5298
    TACAAGTTCACCTGCATT//
    TESTI20018230// SEQ ID NO: 5299
    AACCACTCAGCAGAAAGA//
    TESTI20035960// SEQ ID NO: 5300
    TGTCCATAGAGCCAGTTA//
    TESTI20038270// SEQ ID NO: 5301
    GTTCTGTTGGAGGTGCTG//
    TESTI20044230// SEQ ID NO: 5302
    AGGTCTTTTGTGTGCTGA//
    TESTI20046750// SEQ ID NO: 5303
    GTAGTTGTCCTGCATGGC//
    TESTI20060400// SEQ ID NO: 5304
    GGCCAGGATACTACACTT//
    TESTI20066770// SEQ ID NO: 5305
    AACTGGCATTGGAGACCT//
    TESTI20076850// SEQ ID NO: 5306
    TTGGTTTGTGATGTTAAGT//
    TESTI20083940// SEQ ID NO: 5307
    TTTGTCTTCCGGTAGTTA//
    TESTI20087620// SEQ ID NO: 5308
    TGCCACTCTTGAAAACTC//
    TESTI20098530// SEQ ID NO: 5309
    TCCATTACACAACAGCCT//
    TESTI20105720// SEQ ID NO: 5310
    GGCAGACTTGTTTGAGCT//
    TESTI20108720// SEQ ID NO: 5311
    TAGTTCTGTTGAGGCCCC//
    TESTI20123080// SEQ ID NO: 5312
    (Reaction system A)//
    CCTGTTTCTCTTCCTGAA//
    //(Reaction system B)// SEQ ID NO: 5313
    CTAAGTCCAGAAGCCTCG//
    TESTI20128350// SEQ ID NO: 5314
    ATACCATGCTCCAACACC//
    TESTI20136100// SEQ ID NO: 5315
    TTCACTTTTGTTCTCCAG//
    TESTI20137670// SEQ ID NO: 5316
    CCTCCACTCTTCCTGTTG//
    TESTI20143240// SEQ ID NO: 5317
    CTAAGAAGTCCTGGTTGG//
    TESTI20143620// SEQ ID NO: 5318
    (Reaction system A)//
    TTTTGTCTGAATTTGGAA//
    //(Reaction system B)// SEQ ID NO: 5319
    TGTAGAAAGCCTAACCCC//
    TESTI20156100// SEQ ID NO: 5320
    ACTGGGCACATTCATAAA//
    TESTI20161970// SEQ ID NO: 5321
    GTTCTATGCCTTGAGCCT//
    TESTI20168480// SEQ ID NO: 5322
    AACTCTGGGTACCAACTT//
    TESTI20168960// SEQ ID NO: 5323
    CTCCCTCTCCTTTCCTCA//
    TESTI20178160// SEQ ID NO: 5324
    CGTTTTCTCGATGTCCAG//
    TESTI20185810// SEQ ID NO: 5325
    AACATTCCTTGCAGCTCA//
    TESTI20199170// SEQ ID NO: 5326
    AGAGTGAGCTGTGCCTTG//
    TESTI20200260// SEQ ID NO: 5327
    CCAAGACATACCCAGGCT//
    TESTI20200710// SEQ ID NO: 5328
    AATTGTGACAAGCAGCAG//
    TESTI20202650// SEQ ID NO: 5329
    TGTTCATGTCACTGGCTG//
    TESTI20220100// SEQ ID NO: 5330
    (Reaction system A)//
    CTTCATAGGGCAGACTCC//
    //(Reaction system B)// SEQ ID NO: 5331
    GCTGTGAACTAGAGGGGC//
    TESTI20224620// SEQ ID NO: 5332
    GGAGAAACCGATGAAGAA//
    TESTI20229600// SEQ ID NO: 5333
    (Reaction system A)//
    TTTAATAGTGCCCTGTGG//
    //(Reaction system B)// SEQ ID NO: 5334
    CTCTGGAATTTGCATTGA//
    TESTI20230850// SEQ ID NO: 5335
    CAAGACTATGGAGGGGAG//
    TESTI20231920// SEQ ID NO: 5336
    CTCCTCTTGCATTCTCCC//
    TESTI20234140// SEQ ID NO: 5337
    CCAGTTATATCCCCAAAA//
    TESTI20234270// SEQ ID NO: 5338
    CATAAAACCGAATAACTGAG//
    TESTI20238000// SEQ ID NO: 5339
    AGTGTTTGTGGGCATAGA//
    TESTI20238610// SEQ ID NO: 5340
    ACTTCAGACCTCCCTAGA//
    TESTI20239510// SEQ ID NO: 5341
    TTATTGAAGGAAAGCCGC//
    TESTI20242990// SEQ ID NO: 5342
    CCCTGCCTTCCCTATAGA//
    TESTI20265250// SEQ ID NO: 5343
    GGGAAATAGAGGAGTGAT//
    TESTI20265370// SEQ ID NO: 5344
    TGGTTTCAGATGTGCCTT//
    TESTI20266740// SEQ ID NO: 5345
    TGGAAGAACGAAAGAGCC//
    TESTI20272390// SEQ ID NO: 5346
    TCCAGGGTGTCGTAGAAG//
    TESTI20275030// SEQ ID NO: 5347
    GCACGTTAAGGACTGTTT//
    TESTI20275620// SEQ ID NO: 5348
    (Reaction system A)//
    TGTGCCTGACTAGGTGAG//
    //(Reaction system B)// SEQ ID NO: 5349
    AAGGACAGGTGAGTGTGG//
    TESTI20277360// SEQ ID NO: 5350
    TGGAGTACAACCTGCATC//
    TESTI20282540// SEQ ID NO: 5351
    TGTCTGGTAGAGTTGCGG//
    TESTI20284880// SEQ ID NO: 5352
    TGATTTAATGAGTGGAACC//
    TESTI20285830// SEQ ID NO: 5353
    (Reaction system A)//
    CATGTGACCTTCTCTGGC//
    //(Reaction system B)// SEQ ID NO: 5354
    CAGTTCTTTAGCCAGGGA//
    TESTI20288110// SEQ ID NO: 5355
    CCTTTTGTCTGATTCGTC//
    TESTI20289850// SEQ ID NO: 5356
    CCTTACCAAACTCATCCA//
    TESTI20307540// SEQ ID NO: 5357
    CGTGCATGAAAGTGAGTC//
    TESTI20308600// SEQ ID NO: 5358
    CTTCTCAATCATCAGGGA//
    TESTI20311290// SEQ ID NO: 5359
    TTCTCTGCACTCCTTGAT//
    TESTI20317600// SEQ ID NO: 5360
    GAGTGTCTGGCATGGTTA//
    TESTI20319190// SEQ ID NO: 5361
    AAGCTGGGATGATAAGGG//
    TESTI20332420// SEQ ID NO: 5362
    (Reaction system A)//
    CTTCTTGGTGCTGCTTTT//
    //(Reaction system B)// SEQ ID NO: 5363
    GCAGATATGTTTGTGAGAG//
    TESTI20335200// SEQ ID NO: 5364
    AATAAACTACACCAGGGC//
    TESTI20342430// SEQ ID NO: 5365
    TCCTACGTTGAGTTGCCT//
    TESTI20345060// SEQ ID NO: 5366
    GTCCACTAGAAGAGGGTC//
    TESTI20347300// SEQ ID NO: 5367
    GAAAGCTGTCGTTAAGGT//
    TESTI20357960// SEQ ID NO: 5368
    AATGACAGGTGAGTGGGT//
    TESTI20361140// SEQ ID NO: 5369
    AATTCACCAGGCTGTGTG//
    TESTI20369220// SEQ ID NO: 5370
    (Reaction system A)//
    TGGATTTGGAAGAGACCT//
    //(Reaction system B) SEQ ID NO: 5371
    //TTTGGGTGGAAGTAGAGA//
    TESTI20369690// SEQ ID NO: 5372
    GCTGGTTATTCACGTGGT//
    TESTI20370020// SEQ ID NO: 5373
    (Reaction system A)//
    TGGTCATACTCACTGCCC//
    //(Reaction system B)// SEQ ID NO: 5374
    GACCTGGTCATACTCACTG//
    TESTI20371030// SEQ ID NO: 5375
    CTAAAGTCCAAAATGTGTAAGT//
    TESTI20386230// SEQ ID NO: 5376
    (Reaction system A)//
    GCTAAGGTGCTATGAAGG//
    //(Reaction system B)// SEQ ID NO: 5377
    ACAGTAAAAGGGCAAGTG//
    TESTI20391210// SEQ ID NO: 5378
    AATACTCACATGCCAAGC//
    TESTI20392090// SEQ ID NO: 5379
    CTTGGTTACAGAGGACAG//
    TESTI20392250// SEQ ID NO: 5380
    ATTCCACTCTGCTCAAAG//
    TESTI20392270// SEQ ID NO: 5381
    CCTTGTTGTCCATGAGTC//
    TESTI20401020// SEQ ID NO: 5382
    CGTACACCACATAGCTGA//
    TESTI20401430// SEQ ID NO: 5383
    TGGTAGAAAGAGAGTCACAT//
    TESTI20409440// SEQ ID NO: 5384
    TAGAGCACGTTTCCCTGA//
    TESTI20415640// SEQ ID NO: 5385
    TCTGGAAAATGAGGGTTA//
    TESTI20424000// SEQ ID NO: 5386
    CCAGCTTTCTTCATCATC//
    TESTI20424730// SEQ ID NO: 5387
    AGGAGTGTGGCATAGTCA//
    TESTI20425070// SEQ ID NO: 5388
    AAAGCCATCAGACCTCAT//
    TESTI20433130// SEQ ID NO: 5389
    GTCCCATGATTTAGAACTC//
    TESTI20438570// SEQ ID NO: 5390
    CTGCACTAGCCTTTTCCA//
    TESTI20443090// SEQ ID NO: 5391
    GGAAGACAGGACCCAAGT//
    TESTI20463520// SEQ ID NO: 5392
    TGTTGGACTAGAGGGGAA//
    TESTI20465520// SEQ ID NO: 5393
    TCCAGGTCTCATTCTCTC//
    TESTI20478010// SEQ ID NO: 5394
    TCCCTATCAGACGACCAG//
    TESTI20478180// SEQ ID NO: 5395
    AAATCACCCTGCTTGTCA//
    THYMU20029100// SEQ ID NO: 5396
    AGAAGCCAGGGAAGAGGT//
    THYMU20061700// SEQ ID NO: 5397
    CTAGCTCTGAAGTGGCAT//
    THYMU20095960// SEQ ID NO: 5398
    (Reaction system A)//
    TGAAGAGATTACCCAGGT//
    //(Reaction system B)// SEQ ID NO: 5399
    GGACTCTGTAGATGTAACTGA//
    THYMU20111180// SEQ ID NO: 5400
    (Reaction system A)//
    TTCTGGGTAAGCCTGATT//
    //(Reaction system B)// SEQ ID NO: 5401
    CAAAGAATACCACAAATAGC//
    THYMU20118060// SEQ ID NO: 5402
    CCAAGGCTAAAGAGAGAG//
    THYMU20130890// SEQ ID NO: 5403
    (Reaction system A)//
    AATCTCAAGGACCAGTTT//
    //(Reaction system B)// SEQ ID NO: 5404
    GACACAATGGACTCAAAA//
    THYMU20142040// SEQ ID NO: 5405
    ACAGAAGGCCACAGTCAG//
    THYMU20142970// SEQ ID NO: 5406
    CAAGGATACTGTGATGAAA//
    THYMU20153160// SEQ ID NO: 5407
    GGTGGTTAGGACATTTCTC//
    THYMU20158250// SEQ ID NO: 5408
    AAGGAGTGGATAGATGAATAG//
    THYMU20187720// SEQ ID NO: 5409
    TGGTTACAAAGTCACAGG//
    THYMU20194360// SEQ ID NO: 5410
    TTCACTTTTGTTTCCCAG//
    THYMU20208300// SEQ ID NO: 5411
    ATACCACTAAGGCCCAGG//
    THYMU20226600// SEQ ID NO: 5412
    GACTCTTTCAGCTGCTGC//
    THYMU20239000// SEQ ID NO: 5413
    CAAATGGACAGGAACTTA//
    THYMU20253250// SEQ ID NO: 5414
    (Reaction system A)//
    AGAAAACCAGATAGGGCC//
    //(Reaction system B)// SEQ ID NO: 5415
    TAATGCAGGGAATGGAGT//
    THYMU20272490// SEQ ID NO: 5416
    CATTATACACACGACGAA//
    THYMU20284120// SEQ ID NO: 5417
    AAACCCACAGTGCTTCAT//
    THYMU20286290// SEQ ID NO: 5418
    AGTCCCTCTCATTTCCAG//
    TKIDN10000010// SEQ ID NO: 5419
    TGCCATAATTCTCCTTTT//
    TRACH20005020// SEQ ID NO: 5420
    GCTTTTCTCCTTCCATGA//
    TRACH20032720// SEQ ID NO: 5421
    CTACGCCCACTATATTCA//
    TRACH20041830// SEQ ID NO: 5422
    (Reaction system A)//
    AGATACTGAGAATGAGCCT//
    //(Reaction system B)// SEQ ID NO: 5423
    TTTCCATGCCTACCCTTT//
    TRACH20060150// SEQ ID NO: 5424
    (Reaction system A)//
    AGTCTCCTGCTGGCTAAG//
    //(Reaction system B)// SEQ ID NO: 5425
    GTCCCTTCTGTCTCCTGA//
    TRACH20076760// SEQ ID NO: 5426
    GTGGAAGTGCCTGATGAG//
    TRACH20082780// SEQ ID NO: 5427
    CTTTCACCTGGGATGGAT//
    TRACH20091230// SEQ ID NO: 5428
    AACATAGTCATTTCGTTCA//
    TRACH20099340// SEQ ID NO: 5429
    GAGCACTGTAAGAGCCAT//
    TRACH20109650// SEQ ID NO: 5430
    AAACATACCACGGAGAGA//
    TRACH20115740// SEQ ID NO: 5431
    TATGAGCACACGAGGTCC//
    TRACH20134950// SEQ ID NO: 5432
    AAGAGGGAACATCAGGCT//
    TRACH20135520// SEQ ID NO: 5433
    TTCTTGGGCTTTATGTGG//
    TRACH20153810// SEQ ID NO: 5434
    (Reaction system A)//
    GCAGTGAGTCGTAGATGA//
    //(Reaction system B)// SEQ ID NO: 5435
    CTGCCTAGCCCTCTCACT//
    TRACH20184490// SEQ ID NO: 5436
    ACTGTGAAGAGCCTGTTG//
    TSTOM20001390// SEQ ID NO: 5437
    GGAATAGTAAGGACATAATGACA//
    TSTOM20005690// SEQ ID NO: 5438
    GGAACCTTTTGTAACCCT//
    UMVEN10001560// SEQ ID NO: 5439
    GCCACAACATCATTTTACTT//
    UMVEN20003540// SEQ ID NO: 5440
    AAGTAAAAGACATCGGCA//
    UTERU20004240// SEQ ID NO: 5441
    TACCTCCAGACTTTTGTG//
    UTERU20046980// SEQ ID NO: 5442
    AGGATGGGAAGAAGGTTT//
    UTERU20055930// SEQ ID NO: 5443
    GGATGAGTTGTGTGAAAA//
    UTERU20068990// SEQ ID NO: 5444
    CCAAGGCTAAAGAGAGAG//
    UTERU20070810// SEQ ID NO: 5445
    AAGTAGAGAATCCCAGCT//
    UTERU20115740// SEQ ID NO: 5446
    TTTATGATTGAGGGGACC//
    UTERU20119060// SEQ ID NO: 5447
    ACAGCATCCAATCAAAGA//
    UTERU20124070// SEQ ID NO: 5448
    ACATCTGGTGGAAGCATC//
    UTERU20126880// SEQ ID NO: 5449
    ACCTTAACCCCTCTTCCC//
    UTERU20134910// SEQ ID NO: 5450
    AAGGAAGCCAACTCATGC//
    UTERU20146680// SEQ ID NO: 5451
    ACCTTAACCCCTCTTCCC//
    UTERU20176130// SEQ ID NO: 5452
    TAGAAAGGGGTGGTGAGA//
    UTERU20185230// SEQ ID NO: 5453
    CGTTGAGAGCTTTTACAG//
    UTERU20186740// SEQ ID NO: 5454
    CCACTTTGAGAGAACCCT//
  • The result of expression frequency analysis is shown in Table 52. The clones not shown in the table contain clones whose expression levels could not be measured because the levels were too low or the sizes of the PCR products were different from the expected. It was confirmed that the expression levels of IL-8 genes used as positive control genes were elevated.
  • The result obtained by the search for the genes whose expression levels were altered depending on the presence of TNF-α in culturing THP-1 cell, which is a human monocyte cell line, showed that the clones whose expression levels were elevated by twofold or more one or three hours after the stimulation (the clones whose expression levels were 0.1 or lower both before and after the stimulation were excluded), were ASTRO20152140,
  • BRACE20057620, BRACE20060720, BRACE20090440, BRACE20152870, BRACE20229280, BRAMY20002770, BRAMY20266850, BRAMY20280720, BRAWH20106180, BRAWH20122770, BRHIP20096170, BRHIP20111200, BRHIP20186120, BRHIP20194940, BRHIP20207430, BRSSN20152380, CTONG20095270, CTONG20100240, CTONG20158150,
  • CTONG20265130, D30ST20006540, D90ST20031370, FCBBF20071860, FCBBF30251420, FCBBF30252520, FCBBF40001420, FEBRA20017050, FEBRA20082100, HCHON20011160, KIDNE20141190, KIDNE20163880, KIDNE20182690, LIVER10004790, LIVER20038540, LIVER20085800, MESAN20130220, MESAN20174170, NT2NE20158600, NT2RI20005750, NT2RP70110860, NT2RP70169110, NT2RP70175670, NT2RP70188710, PERIC20002140, PLACE60155130, PROST20120160, PROST20149250, PROST20161950, PUAEN20015260, SKNSH20080430, SMINT20051610, SMINT20060780, SMINT20161220, SMINT20163960, SPLEN20101190, SPLEN20157300, SPLEN20163560, SPLEN20214580, SPLEN20279950, STOMA20048520, TESTI20076850, TESTI20087620, TESTI20108720, TESTI20220100, TESTI20239510, TESTI20266740, TESTI20342430, TESTI20370020, TESTI20391210, TESTI20401020, TESTI20415640, THYMU20130890, THYMU20286290, TRACH20060150, TRACH20099340, UTERU20004240, UTERU20068990, UTERU20119060.
  • On the other hand, in particular cases where the expression levels were relatively high in the unstimulated cells (the relative value was 1 or higher), the clones whose expression levels were decreased by twofold or more by the TNF-α stimulation (the clones whose expression levels were increased 1 or 3 hours after the stimulation were excluded) were
  • ASTRO20032120, ASTRO20084250, ASTRO20181690, BRACE20062640, BRACE20067430, BRACE20235400, BRALZ20018340, BRALZ20069760, BRALZ20075450, BRAMY20163270, BRAMY20204450, BRAMY20218670, BRAMY20229800, BRAWH10000930, BRAWH20107540, BRAWH20132190, BRAWH20158530, BRCAN20273340, BRHIP20105710, BRHIP20186120, BRSSN20176820, CTONG20095290, DFNES20031920, FCBBF30033050, FCBBF30071520, FCBBF30083820, HCHON20008980, HCHON20022470, HHDPC20034390, KIDNE20028720, KIDNE20079440, KIDNE20127750, KIDNE20148900, LIVER20011130, MAMGL10000830, MESAN20127350, NT2NE20181650, NT2RI20023160, NT2RP70102350, NT2RP70157890, NTONG20029480, OCBBF20020830, OCBBF20041680, OCBBF20061720, OCBBF20127040, OCBBF20139260, OCBBF20178990, PEBLM20013120, PLACE60003480, PLACE60181070, PROST20151240, PUAEN20003740, PUAEN20011880, PUAEN20078980, PUAEN20085150, SKNSH20080430, SMINT20001760, SMINT20047810, SMINT20108530, SPLEN20158990, SPLEN20283650, STOMA20010250, STOMA20057820, TESTI20060400, TESTI20161970, TESTI20275620, TESTI20369690, TESTI20386230, TESTI20392250, TESTI20409440, TESTI20424730, THYMU20095960, THYMU20111180, THYMU20226600, THYMU20253250, THYMU20272490, TRACH20153810, UTERU20176130, UTERU20186740.
  • These clones were thus revealed to be involved in the inflammation reaction induced by TNF-α.
  • The result obtained by the search for the genes whose expression levels were altered depending on co-culturing gastric cancer cell line MKN45 with cag PAI positive Helicobacter pylori (TN2), showed that the clones whose expression levels were elevated by twofold or more (the clones whose expression levels were 0.1 or lower both before and after the stimulation were excluded), were ADRGL20067670, BLADE20004630, BRACE20039040,
  • BRACE20151320, BRACE20229280, BRACE20235400, BRALZ20058880, BRAMY20060920, BRAMY20184670, BRAMY20218670, BRAMY20229800, BRCAN20147880, BRHIP20196410, BRHIP30004880, BRSSN20187310, CD34C30004940, CTONG20265130, DFNES20031920, FCBBF30278630, FCBBF40001420,
  • HHDPC20095280, KIDNE20130450, LIVER20011130, LIVER20038540, NT2NE20172590, NT2RP70169110, OCBBF20085200, OCBBF20180840, PEBLM10000240, PLACE60003480, PROST20120160, PROST20151240, PUAEN20011880, SKMUS20031680, SKNSH20080430, SMINT20056210, SMINT20105000, SPLEN20019450, SPLEN20211570, STOMA20048520, TESTI20004890, TESTI20083940, TESTI20168480, TESTI20239510, TESTI20308600, TESTI20478010, UTERU20126880.
  • Of these clones, the expression levels of ADRGL20067670,
  • BLADE20004630, BRACE20151320, BRACE20229280, BRACE20235400, BRALZ20058880, BRAMY20218670, BRAMY20229800, BRHIP20196410, BRHIP30004880, CD34C30004940, DFNES20031920, FCBBF30278630, FCBBF40001420, HHDPC20095280, KIDNE20130450, LIVER20011130, LIVER20038540, NT2NE20172590, NT2RP70169110,
  • PEBLM10000240, PROST20151240, PUAEN20011880, SKMUS20031680, SKNSH20080430, SMINT20056210, SMINT20105000, SPLEN20019450, SPLEN20211570, STOMA20048520, TESTI20168480, TESTI20308600, TESTI20478010, UTERU20126880 were not increased by the co-culture with the cagE mutant (TN2ΔcagE). There may be the possibility that the expression levels of the 34 clones are altered via the NF-κB pathway. Among them, the expression levels of BRACE20229280, FCBBF40001420, LIVER20038540, NT2RP70169110, SKNSH20080430, STOMA20048520 were also increased when human monocyte cell line THP-1 was stimulated with TNF-α.
  • On the other hand, in particular cases where the expression levels were relatively high in the unstimulated cells (the relative value was 1 or higher), the clones whose expression levels were decreased by twofold or more in the presence of Helicobacter pylori were ASTRO20032120, BRACE20090440,
  • BRACE20114780, BRALZ20064740, BRAMY20002770, BRAMY20210400, BRAMY20215230, BRAMY20247280, BRAMY20267130, BRAWH20029630, BRAWH20100690, BRAWH20118230, BRCOC20105100, BRHIP20218580, BRSSN20046570, CTONG20138030, CTONG20146970, CTONG20158150, D3OST20037970, FCBBF30001840,
  • FCBBF30033050, FEBRA20082100, HCHON20035130, HCHON20043590, HCHON20067220, NT2NE20174920, NT2RI20009870, NT2RI20023160, NT2RP70062230, NT2RP70130020, NTONG20070340, OCBBF20020150, OCBBF20094240, OCBBF20107920, PROST20144220, PROST20149160, PROST20153320, PUAEN20003740, PUAEN20025680, PUAEN20040670, SMINT20014580, SPLEN20101190, STOMA20076800, TESTI20087620, TESTI20098530, TESTI20123080, TESTI20161970, TESTI20234140, TESTI20288110, TESTI20357960, TESTI20391210, TESTI20424730, THYMU20158250, THYMU20226600, TRACH20005020, TRACH20134950, TRACH20184490, TSTOM20001390, UTERU20119060, UTERU20134910, UTERU20176130.
  • These clones are involved in gastritis or gastroduodenal ulcer.
    TABLE 3
    CloneID CD34C D3OST D6OST D9OST
    ASTRO20001410 0 17.731 0 20.479
    D3OST10001090 0 62.515 0 24.068
    D3OST20036070 0 46.404 0 53.596
    THYMU20039810 0 18.291 0 21.126
    KIDNE20028720 0 0 38.385 46.259
    BRAWH10000930 0 0 0 6.219
    BRHIP20005340 0 0 0 4.615
    CTONG20141650 0 0 0 64.925
    D9OST20000310 0 0 0 63.705
    D9OST20002780 0 0 0 100
    D9OST20023970 0 0 0 37.837
    D9OST20026730 0 0 0 19.695
    D9OST20031370 0 0 0 100
    D9OST20033970 0 0 0 38.536
    D9OST20035800 0 0 0 93.047
    D9OST20035940 0 0 0 100
    D9OST20040180 0 0 0 100
    FCBBF30018550 0 0 0 37.763
    FCBBF30233680 0 0 0 33.084
    KIDNE20102650 0 0 0 63.715
    NT2RI20023160 0 0 0 10.811
    PROST20107820 0 0 0 3.279
    SKNSH20089400 0 0 0 25.857
    SMINT20033400 0 0 0 39.619
    CTONG20108210 0 0 47.973 0
    D6OST20003580 0 0 95.4 0
    D6OST20005070 0 0 100 0
    ASTRO20155290 0 21.631 0 0
    D3OST10002670 0 50.415 0 0
    D3OST10002700 0 30.165 0 0
    D3OST20006180 0 100 0 0
    D3OST20006540 0 100 0 0
    D3OST20007340 0 93.334 0 0
    D3OST20013280 0 100 0 0
    D3OST20024170 0 100 0 0
    D3OST20024360 0 100 0 0
    D3OST20037970 0 100 0 0
    D3OST30002580 0 72.574 0 0
    D3OST30002910 0 93.334 0 0
    FCBBF10004120 0 22.594 0 0
    NT2RI20001330 0 29.915 0 0
    NTONG20009770 0 11.477 0 0
    SPLEN20084600 0 30.589 0 0
    SPLEN20140800 0 55.315 0 0
    THYMU20169680 0 86.295 0 0
    TRACH20141240 0 12.051 0 0
    CD34C30001250 97.628 0 0 0
    CD34C30003140 100 0 0 0
    CD34C30004240 96.167 0 0 0
    CD34C30004940 100 0 0 0
    DFNES10001850 55.393 0 0 0
    HHDPC20034390 21.364 0 0 0
    NT2RI20091730 46.845 0 0 0
    SKMUS20003610 44.913 0 0 0
    SPLEN20225220 59.537 0 0 0
    BRCOC20101230 46.01 0 0 14.772
  • TABLE 4
    Clone ID NT2RM NT2RP NT2RI NT2NE
    CTONG20027090 62.349 0 0 0
    CTONG20160560 57.22 0 0 0
    NT2RP70032610 39.095 3.274 0 0
    OCBBF20188730 39.876 0 0 0
    SPLEN20162680 12.432 0 2.355 6.263
    BRCOC20101230 0 2.64 3.981 3.97
    BRHIP20005340 0 0.825 1.244 1.24
    BRHIP20238880 0 2.66 7.355 2.667
    FCBBF30016320 0 7.441 2.805 5.595
    FEBRA20080810 0 6.827 5.147 2.566
    FEBRA20225040 0 3.958 2.985 5.952
    HCHON20008320 0 17.053 19.287 12.822
    HHDPC20034390 0 0.613 1.387 0.922
    HLUNG10000550 0 2.609 0.984 1.962
    NT2RI20028470 0 9.076 6.843 4.549
    NT2RI20054050 0 2.03 1.02 4.069
    NT2RI20091730 0 2.688 2.027 4.042
    NT2RP70078420 0 4.623 3.485 13.902
    PUAEN20003740 0 2.314 0.582 1.16
    THYMU20271250 0 0.431 0.651 1.297
    BRACE20003070 0 8.516 4.281 0
    BRACE20039040 0 6.248 4.711 0
    BRAWH20004600 0 1.471 5.545 0
    BRAWH20011710 0 8.931 2.245 0
    BRCOC20121720 0 13.559 5.112 0
    BRHIP20005530 0 12.387 9.34 0
    D3OST10002700 0 6.227 4.695 0
    HCHON20007380 0 7.176 5.411 0
    HEART20072310 0 11.675 17.605 0
    KIDNE20121880 0 21.519 16.225 0
    MESAN20121130 0 14.219 10.721 0
    NT2RI20022600 0 57.012 42.988 0
    NT2RI20023160 0 1.932 1.457 0
    NT2RI20086220 0 7.606 5.735 0
    NT2RI20216250 0 45.928 34.63 0
    NT2RP60000850 0 11.147 16.809 0
    NT2RP70036880 0 1.78 5.367 0
    NT2RP70043480 0 10.893 4.107 0
    NT2RP70062230 0 10.183 7.678 0
    NT2RP70081610 0 15.131 22.818 0
    NT2RP70102350 0 84.14 15.86 0
    NT2RP70130020 0 57.012 42.988 0
    NT2RP70190640 0 30.952 23.338 0
    OCBBF10001850 0 20.293 7.65 0
    OCBBF20097720 0 5.676 4.28 0
    OCBBF20173980 0 3.1 2.338 0
    PEBLM20044520 0 3.253 2.453 0
    SPLEN20173510 0 7.249 10.932 0
    TRACH20007020 0 9.462 7.134 0
    UTERU20065930 0 10.676 8.05 0
    HCHON20022470 0 6.766 0 10.174
    NT2NE20010490 0 21.179 0 31.847
    NT2NE20174800 0 39.941 0 60.059
    NT2NE20177520 0 28.292 0 42.542
    PROST20087700 0 1.88 0 14.135
    PROST20107820 0 0.586 0 2.644
    SMINT20028820 0 6.998 0 10.523
    TESTI20063830 0 9.768 0 14.689
    ASTRO20125520 0 0 2.686 5.357
    BRHIP30001110 0 0 1.86 3.71
    HCHON20002260 0 0 0.733 1.461
    HCHON20008150 0 0 5.075 20.242
    KIDNE20002520 0 0 1.553 6.195
    NT2NE20130190 0 0 33.397 66.603
    NT2NE20158600 0 0 33.397 66.603
    NT2RI20001330 0 0 4.656 9.286
    NT2RI20025400 0 0 3.141 6.265
    NT2RI20036670 0 0 33.397 66.603
    NT2RI20048840 0 0 1.404 5.6
    SKMUS20020840 0 0 11.346 22.628
    BRACE20057190 0 0 0 10.763
    BRACE20060550 0 0 0 14.499
    BRACE20267250 0 0 0 66.449
    BRAWH20107540 0 0 0 40.54
    BRAWH20118230 0 0 0 78.374
    CTONG20075860 0 0 0 21.782
    CTONG20095290 0 0 0 22.915
    FEBRA20086620 0 0 0 11.505
    FEBRA20144170 0 0 0 1.957
    FEBRA20196370 0 0 0 59.247
    HLUNG20023340 0 0 0 33.313
    NT2NE20003740 0 0 0 100
    NT2NE20010050 0 0 0 84.719
    NT2NE20010210 0 0 0 100
    NT2NE20010400 0 0 0 56.184
    NT2NE20015240 0 0 0 100
    NT2NE20021620 0 0 0 44.305
    NT2NE20043780 0 0 0 100
    NT2NE20053580 0 0 0 75.239
    NT2NE20068130 0 0 0 100
    NT2NE20072200 0 0 0 100
    NT2NE20074250 0 0 0 100
    NT2NE20080170 0 0 0 100
    NT2NE20089610 0 0 0 100
    NT2NE20089970 0 0 0 100
    NT2NE20108540 0 0 0 84.719
    NT2NE20110360 0 0 0 100
    NT2NE20118960 0 0 0 100
    NT2NE20122430 0 0 0 76.57
    NT2NE20124480 0 0 0 100
    NT2NE20125050 0 0 0 66.449
    NT2NE20131890 0 0 0 100
    NT2NE20132170 0 0 0 100
    NT2NE20142210 0 0 0 100
    NT2NE20146810 0 0 0 100
    NT2NE20152750 0 0 0 100
    NT2NE20155110 0 0 0 100
    NT2NE20156260 0 0 0 100
    NT2NE20157470 0 0 0 100
    NT2NE20159740 0 0 0 27.684
    NT2NE20172590 0 0 0 100
    NT2NE20174920 0 0 0 61.159
    NT2NE20181650 0 0 0 100
    NT2NE20183760 0 0 0 100
    NT2NE20184900 0 0 0 84.719
    NT2NE20187390 0 0 0 100
    OCBBF20108430 0 0 0 53.98
    RECTM20005100 0 0 0 10.923
    SMINT20001760 0 0 0 50.667
    SPLEN20169720 0 0 0 7.349
    TESTI20265250 0 0 0 15.768
    ASTRO10001650 0 0 8.055 0
    ASTRO20033160 0 0 10.721 0
    BRACE20011070 0 0 26.748 0
    BRACE20039440 0 0 0.941 0
    BRACE20151320 0 0 29.94 0
    BRAMY20104640 0 0 40.041 0
    BRAMY20137560 0 0 68.63 0
    BRAMY20167060 0 0 9.007 0
    BRAWH20028110 0 0 15.672 0
    BRCAN20280360 0 0 4.387 0
    BRCOC20004870 0 0 0.526 0
    BRHIP20207990 0 0 9.197 0
    BRHIP20217620 0 0 5.063 0
    BRHIP20249110 0 0 67.372 0
    BRSTN10000830 0 0 3.481 0
    CTONG10000940 0 0 1.415 0
    CTONG20004690 0 0 5.307 0
    CTONG20050280 0 0 12.439 0
    CTONG20105660 0 0 24.642 0
    CTONG20125640 0 0 7.18 0
    CTONG20133520 0 0 49.384 0
    CTONG20186320 0 0 29.069 0
    FCBBF10000770 0 0 1.472 0
    FCBBF10002800 0 0 10.265 0
    FCBBF10003770 0 0 19.652 0
    FCBBF30018550 0 0 5.089 0
    FCBBF30123470 0 0 3.989 0
    FCBBF30246230 0 0 5.091 0
    FEBRA20018280 0 0 9.887 0
    FEBRA20095140 0 0 6.019 0
    FEBRA20192420 0 0 58.974 0
    HCHON20064590 0 0 19.614 0
    HHDPC10000830 0 0 1.779 0
    HLUNG20016770 0 0 6.385 0
    HLUNG20033780 0 0 16.824 0
    IMR3220002430 0 0 3.118 0
    KIDNE20104300 0 0 17.33 0
    MESAN20004570 0 0 7.197 0
    MESAN20089360 0 0 14.459 0
    NOVAR10000910 0 0 3.519 0
    NT2RI20003480 0 0 32.207 0
    NT2RI20005750 0 0 100 0
    NT2RI20009870 0 0 100 0
    NT2RI20023590 0 0 29.911 0
    NT2RI20023910 0 0 11.79 0
    NT2RI20025640 0 0 100 0
    NT2RI20040930 0 0 100 0
    NT2RI20041880 0 0 10.436 0
    NT2RI20046080 0 0 6.723 0
    NT2RI20050960 0 0 73.545 0
    NT2RI20055790 0 0 17.054 0
    NT2RI20056700 0 0 100 0
    NT2RI20069730 0 0 100 0
    NT2RI20076290 0 0 14.653 0
    NT2RI20091940 0 0 5.358 0
    NT2RI20198260 0 0 100 0
    NT2RI20203900 0 0 100 0
    NT2RI20207030 0 0 100 0
    NT2RI20240080 0 0 61.866 0
    NT2RI20244600 0 0 100 0
    NT2RI20244960 0 0 100 0
    NT2RI20250750 0 0 30.809 0
    NT2RI20252550 0 0 62.102 0
    NT2RI20273230 0 0 60.375 0
    NTONG20067090 0 0 16.469 0
    OCBBF10001750 0 0 13.09 0
    OCBBF20047570 0 0 4.504 0
    OCBBF20054760 0 0 8.495 0
    OCBBF20059560 0 0 10.318 0
    OCBBF20073540 0 0 3.651 0
    OCBBF20125530 0 0 2.131 0
    OCBBF20126780 0 0 12.535 0
    OCBBF20127040 0 0 37.942 0
    OCBBF20140890 0 0 35.863 0
    SKMUS20003610 0 0 1.943 0
    SKNSH20008190 0 0 4.523 0
    SKNSH20080430 0 0 18.4 0
    SMINT20144800 0 0 2.887 0
    SPLEN20027440 0 0 4.053 0
    SPLEN20095550 0 0 15.436 0
    SPLEN20140800 0 0 8.61 0
    TESTI20094020 0 0 16.66 0
    TESTI20369690 0 0 6.529 0
    TESTI20391770 0 0 7.531 0
    TESTI20442760 0 0 17.235 0
    TRACH20084720 0 0 5.703 0
    TRACH20107710 0 0 61.866 0
    TRACH20118940 0 0 16.16 0
    UTERU20022940 0 0 9.896 0
    ASTRO20108190 0 1.622 0 0
    BGGI120006160 0 2.155 0 0
    BRAMY20136210 0 70.518 0 0
    BRAWH20016620 0 22.162 0 0
    BRAWH20164460 0 20.968 0 0
    BRCOC20144000 0 40.488 0 0
    BRHIP20132860 0 82.532 0 0
    BRSSN20146100 0 17.209 0 0
    CTONG10000100 0 15.625 0 0
    CTONG20103480 0 4.268 0 0
    CTONG20108210 0 1.722 0 0
    CTONG20139070 0 10.392 0 0
    FCBBF10000240 0 10.583 0 0
    FCBBF10000630 0 14.415 0 0
    FCBBF20067810 0 30.502 0 0
    FCBBF30010810 0 6.328 0 0
    FCBBF30012810 0 49.073 0 0
    FCBBF30013770 0 24.817 0 0
    FCBBF30039020 0 56.608 0 0
    FCBBF40001420 0 8.811 0 0
    FEBRA10001880 0 5.044 0 0
    FEBRA20082010 0 17.339 0 0
    HHDPC20001040 0 4.459 0 0
    KIDNE20021910 0 34.358 0 0
    NT2RP60000770 0 15.492 0 0
    NT2RP70010740 0 100 0 0
    NT2RP70027380 0 27.748 0 0
    NT2RP70037240 0 22.256 0 0
    NT2RP70044280 0 16.256 0 0
    NT2RP70045590 0 20.543 0 0
    NT2RP70056750 0 7.009 0 0
    NT2RP70063950 0 82.532 0 0
    NT2RP70072690 0 56.608 0 0
    NT2RP70077660 0 74.295 0 0
    NT2RP70085440 0 100 0 0
    NT2RP70105210 0 100 0 0
    NT2RP70110860 0 100 0 0
    NT2RP70111320 0 100 0 0
    NT2RP70122910 0 100 0 0
    NT2RP70125160 0 100 0 0
    NT2RP70133740 0 100 0 0
    NT2RP70134990 0 100 0 0
    NT2RP70137290 0 100 0 0
    NT2RP70137640 0 54.725 0 0
    NT2RP70143480 0 100 0 0
    NT2RP70147210 0 100 0 0
    NT2RP70150800 0 100 0 0
    NT2RP70157890 0 100 0 0
    NT2RP70159960 0 100 0 0
    NT2RP70169110 0 100 0 0
    NT2RP70175670 0 100 0 0
    NT2RP70179710 0 100 0 0
    NT2RP70181970 0 100 0 0
    NT2RP70188020 0 100 0 0
    NT2RP70188710 0 100 0 0
    NT2RP70192730 0 100 0 0
    NT2RP70194450 0 100 0 0
    NT2RP70195430 0 50.987 0 0
    NT2RP70198350 0 2.512 0 0
    NT2RP70203790 0 100 0 0
    OCBBF20039250 0 4.016 0 0
    OCBBF20080410 0 5.038 0 0
    OCBBF20108190 0 30.231 0 0
    OCBBF20108580 0 16.054 0 0
    OCBBF20122620 0 34.956 0 0
    OCBBF20130110 0 18.197 0 0
    OCBBF20151150 0 43.004 0 0
    OCBBF20189560 0 4.079 0 0
    PROST10003220 0 57.613 0 0
    TESTI20001720 0 20.618 0 0
    TESTI20121550 0 15.444 0 0
    TESTI20152460 0 28.533 0 0
    TESTI20211240 0 13.774 0 0
    TESTI20234140 0 39.241 0 0
    UMVEN20003540 0 1.985 0 0
    UTERU20006960 0 6.858 0 0
    UTERU20094350 0 12.888 0 0
    UTERU20164260 0 30.63 0 0
  • TABLE 5
    CloneID BEAST TBAES
    BRACE20039040 0 18.237
    BRAMY20163250 0 26.506
    BRCOC20031250 0 39.975
    BRHIP20005340 0 2.408
    BRHIP20217620 0 19.598
    BRHIP30001110 0 7.202
    FCBBF10000770 0 5.697
    FCBBF30010810 0 18.471
    FEBRA20080810 0 9.963
    FEBRA20144170 0 3.798
    FEBRA20196630 0 61.269
    FEBRA20197110 0 14.875
    HCHON20002260 0 11.347
    HCHON20040020 0 5.523
    HHDPC20034390 0 1.789
    HLUNG10000550 0 3.808
    NOVAR10000910 0 27.245
    NT2RI20023160 0 11.28
    NT2RI20054050 0 1.975
    NT2RI20091730 0 7.846
    OCBBF20188730 0 9.748
    SMINT20144800 0 22.352
    SPLEN20128000 0 2.403
    SPLEN20171210 0 54.539
    SPLEN20264110 0 80.173
    TBAES20000590 0 84.801
    TBAES20002550 0 100
    TBAES20003150 0 100
    TESTI20334410 0 15.439
    TESTI20432750 0 62.244
    TRACH20003590 0 20.978
    TRACH20084720 0 11.037
    UTERU20046640 0 11.937
    BEAST20004540 100 0
    SPLEN20008740 10.632 0
  • TABLE 6
    CloneID CERVX TCERX
    BGGI120006160 0 18.869
    BRAMY20063970 0 59.264
    BRHIP20218580 0 70.621
    FEBRA20002100 0 14.918
    SPLEN20162680 0 9.118
    TESTI20214250 0 36.333
    CTONG20105080 84.727 0
    HCHON20015980 50.212 0
    PROST20175290 52.453 0
    TESTI20254220 51.293 0
    THYMU20279750 82.6 0
  • TABLE 7
    CloneID COLON TCOLN
    ASTRO20001410 0 32.199
    BRAWH20162690 0 27.951
    CTONG20132220 0 79.674
    HCHON20002260 0 17.098
    NT2RI20001330 0 54.324
    TCOLN20001390 0 100
    3NB6910001910 42.978 0
    BRAMY20120910 41.689 0
    BRAWH20004600 4.285 0
    BRCOC20031250 39.895 0
    BRCOC20031870 11.042 0
    COLON10001350 100 0
    COLON20043180 100 0
    COLON20093370 100 0
    FEBRA20002100 4.963 0
    FEBRA20082010 16.836 0
    FEBRA20197110 29.691 0
    KIDNE20007770 53.588 0
    KIDNE20013730 50.02 0
    NT2RP70045590 59.84 0
    OCBBF20078920 29.908 0
    PROST20083600 12.636 0
    SPLEN20011410 6.63 0
    TRACH20084720 11.015 0
    THYMU20271250 1.257 15.18
  • TABLE 8
    CloneID NESOP TESOP
    ASTRO20033160 0 20.183
    ASTRO20125520 0 10.113
    BRAMY20266850 0 16.957
    BRAWH20164460 0 59.524
    BRHIP20005340 0 9.367
    BRHIP20191490 0 75.561
    CTONG20095290 0 43.261
    CTONG20143690 0 28.473
    CTONG20161850 0 17.787
    DFNES20001530 0 21.906
    DFNES20071130 0 45.721
    FCBBF30123470 0 15.017
    FCBBF30175310 0 10.97
    FEBRA20095140 0 45.326
    HCHON20016650 0 10.558
    MESAN20025190 0 31.731
    NT2RI20028470 0 8.588
    NT2RI20054050 0 1.921
    NT2RP70036880 0 5.052
    NTONG20009770 0 6.726
    NTONG20064840 0 29.574
    NTONG20076930 0 48.142
    SMINT20042990 0 61.748
    SPLEN20008820 0 12.019
    SPLEN20128000 0 2.337
    SPLEN20149110 0 7.218
    STOMA20013890 0 39.515
    TESOP20000900 0 100
    TESOP20003120 0 66.097
    TESOP20004000 0 100
    TESOP20005270 0 70.604
    TESOP20005690 0 100
    TESTI20334410 0 7.508
    THYMU20271250 0 2.449
    TRACH20141240 0 7.062
    UTERU20022940 0 12.42
    NESOP10001080 100 0
    NT2RI20023160 17.058 0
    NTONG20013620 74.273 0
    TRACH20077540 31.967 0
    NTONG20015870 69.673 12.221
  • TABLE 9
    CloneID KIDNE TKIDN
    ASTRO20008010 0 3.776
    ASTRO20181690 0 3.496
    BRACE20111830 0 23.795
    BRACE20152870 0 8.501
    BRACE20237270 0 73.082
    BRAMY20147540 0 5.185
    BRAMY20286820 0 78.604
    BRAWH20015350 0 12.794
    BRAWH20096780 0 78.731
    BRAWH20132190 0 35.86
    BRAWH20182060 0 40.908
    BRCAN20060190 0 13.906
    BRCOC20004870 0 1.072
    BRCOC20176520 0 51.098
    BRHIP20000870 0 24.363
    BRHIP20198190 0 32.096
    BRHIP20233090 0 43.183
    BRHIP30001110 0 3.79
    BRSSN20015790 0 49.863
    BRSTN20000580 0 8.929
    CTONG10000940 0 1.442
    CTONG20098440 0 66.526
    CTONG20150910 0 6.012
    CTONG20165050 0 66.526
    DFNES20014040 0 38.579
    DFNES20037420 0 38.579
    FCBBF10000770 0 2.998
    FCBBF30083820 0 39.87
    FCBBF30247930 0 59.143
    FEBRA20037500 0 6.758
    FEBRA20072120 0 14.531
    FEBRA20080810 0 2.621
    FEBRA20086620 0 17.626
    FEBRA20140100 0 59.757
    FEBRA20144170 0 1.999
    FEBRA20176800 0 35.198
    HCHON20008320 0 13.096
    HCHON20059870 0 36.909
    HLUNG10000550 0 2.004
    MESAN20106640 0 32.125
    NT2RI20025400 0 6.399
    NT2RI20076290 0 7.462
    NT2RI20091940 0 3.638
    OCBBF20019830 0 26.741
    OCBBF20022900 0 37.332
    OCBBF20039250 0 3.084
    OCBBF20080050 0 11.755
    OCBBF20097720 0 8.718
    OCBBF20125530 0 4.341
    OCBBF20130110 0 27.949
    OCBBF20140640 0 5.056
    OCBBF20173980 0 9.523
    PANCR10000910 0 1.114
    PROST20087700 0 2.887
    PUAEN20044000 0 26.668
    SPLEN20144520 0 68.029
    SPLEN20160980 0 68.029
    TKIDN10000010 0 41.198
    TKIDN20004640 0 68.029
    TKIDN20005210 0 55.069
    TKIDN20030590 0 78.393
    TKIDN20030620 0 100
    TKIDN20047480 0 35.796
    TRACH20003590 0 11.039
    TRACH20028030 0 7.714
    TRACH20183170 0 10.844
    TRACH20184490 0 56.123
    UMVEN20003540 0 3.049
    UTERU20004240 0 3.144
    UTERU20055930 0 12.464
    ASTRO10001650 7.727 0
    ASTRO20108190 2.346 0
    BGGI120006160 3.117 0
    BRACE20039040 9.038 0
    BRAMY20102080 63.37 0
    BRAWH20004600 2.128 0
    BRAWH20125380 35.37 0
    BRAWH20162690 4.596 0
    BRHIP20115760 66.835 0
    BRHIP20205090 65.282 0
    CTONG20052650 65.178 0
    CTONG20108210 2.491 0
    CTONG20128470 6.004 0
    CTONG20133480 19.179 0
    CTONG20139070 7.516 0
    D9OST20000310 16.47 0
    DFNES20001530 11.162 0
    FCBBF10001820 59.128 0
    FEBRA20002100 4.929 0
    HCHON20008980 35.524 0
    HCHON20016650 5.38 0
    HLUNG20033780 32.277 0
    KIDNE20002520 2.979 0
    KIDNE20003940 100 0
    KIDNE20006780 100 0
    KIDNE20007210 73.728 0
    KIDNE20007770 19.958 0
    KIDNE20008010 100 0
    KIDNE20009470 8.811 0
    KIDNE20011170 77.71 0
    KIDNE20011400 100 0
    KIDNE20013730 24.839 0
    KIDNE20017130 54.019 0
    KIDNE20018730 100 0
    KIDNE20018970 100 0
    KIDNE20020150 100 0
    KIDNE20021680 100 0
    KIDNE20021910 24.85 0
    KIDNE20021980 100 0
    KIDNE20022620 100 0
    KIDNE20024830 100 0
    KIDNE20027250 35.87 0
    KIDNE20027950 100 0
    KIDNE20028390 25.593 0
    KIDNE20028720 1.993 0
    KIDNE20028830 7.907 0
    KIDNE20029800 10.988 0
    KIDNE20067330 100 0
    KIDNE20079440 35.045 0
    KIDNE20096280 100 0
    KIDNE20096470 100 0
    KIDNE20100070 100 0
    KIDNE20100840 100 0
    KIDNE20101370 100 0
    KIDNE20101510 100 0
    KIDNE20102650 8.237 0
    KIDNE20102710 100 0
    KIDNE20104300 33.246 0
    KIDNE20106740 100 0
    KIDNE20107390 100 0
    KIDNE20107500 74.264 0
    KIDNE20107620 100 0
    KIDNE20109730 100 0
    KIDNE20109890 100 0
    KIDNE20112000 100 0
    KIDNE20115080 65.178 0
    KIDNE20118580 100 0
    KIDNE20120090 33.186 0
    KIDNE20121880 62.256 0
    KIDNE20122910 83.085 0
    KIDNE20124400 6.171 0
    KIDNE20125630 100 0
    KIDNE20126010 100 0
    KIDNE20126130 100 0
    KIDNE20127100 33.012 0
    KIDNE20127450 100 0
    KIDNE20127750 100 0
    KIDNE20130450 100 0
    KIDNE20131580 63.24 0
    KIDNE20132180 100 0
    KIDNE20137340 100 0
    KIDNE20138010 100 0
    KIDNE20141190 49.697 0
    KIDNE20144890 100 0
    KIDNE20148900 100 0
    KIDNE20163880 100 0
    KIDNE20180710 49.105 0
    KIDNE20181660 100 0
    KIDNE20182690 100 0
    KIDNE20186780 100 0
    KIDNE20190740 100 0
    LIVER20035110 28.683 0
    MESAN20025190 16.169 0
    NT2RP70043480 7.879 0
    PROST20107820 1.696 0
    PROST20123530 32.771 0
    PROST20161950 20.387 0
    PUAEN20030180 46.744 0
    SKMUS20003610 3.728 0
    SMINT20033400 10.243 0
    TBAES20000590 5.253 0
    TESTI20044310 29.162 0
    TESTI20082330 45.847 0
    TRACH20032720 12.917 0
    UTERU20099720 12.351 0
  • TABLE 10
    CloneID LIVER TLIVE
    BRAWH20166790 83.525 0
    CTONG20103480 15.35 0
    HEART20005410 11.598 0
    LIVER10001260 66.455 0
    LIVER10004790 100 0
    LIVER20002160 100 0
    LIVER20011130 92.988 0
    LIVER20011910 100 0
    LIVER20028420 16.548 0
    LIVER20035110 71.317 0
    LIVER20035680 100 0
    LIVER20038540 100 0
    LIVER20045650 100 0
    LIVER20055200 100 0
    LIVER20055440 100 0
    LIVER20059810 24.82 0
    LIVER20062510 100 0
    LIVER20064100 88.658 0
    LIVER20064690 100 0
    LIVER20075680 100 0
    LIVER20080530 100 0
    LIVER20084730 100 0
    LIVER20085800 100 0
    LIVER20087510 75.266 0
    LIVER20091180 100 0
    NTONG20063010 47.641 0
    PROST20087700 6.762 0
    PROST20107820 2.108 0
    TRACH20005400 12.349 0
    ASTRO20001410 0 10.441
    ASTRO20125520 0 10.162
    BRACE20152870 0 15.788
    BRAMY20167060 0 34.076
    BRAMY20181220 0 87.217
    BRAMY20285160 0 81.346
    BRCOC20001860 0 20.45
    FEBRA20144170 0 3.712
    HLUNG10000550 0 3.721
    OCBBF20073540 0 6.907
    OCBBF20088220 0 16.388
    PLAGE60169420 0 26.895
    SMINT20152940 0 54.735
    SPLEN20242320 0 45.601
    THYMU20000570 0 18.649
    TRACH20077540 0 30.987
    UTERU20055930 0 15.433
    UTERU20065930 0 10.151
  • TABLE 11
    CloneID HLUNG TLUNG
    BRACE20096200 70.38 0
    BRAWH20004600 2.238 0
    BRAWH20030250 11.121 0
    BRCAN20006390 61.519 0
    BRCAN20280360 8.855 0
    BRHIP20238880 1.35 0
    CTONG10000940 1.428 0
    CTONG20103480 6.495 0
    CTONG20129960 10.709 0
    CTONG20155180 48.707 0
    FCBBF10001210 36.439 0
    FEBRA20144170 1.98 0
    FEBRA20197110 7.756 0
    HCHON20002260 2.958 0
    HHDPC20034390 0.933 0
    HLUNG10000550 3.971 0
    HLUNG20016330 29.367 0
    HLUNG20016770 12.888 0
    HLUNG20017120 12.093 0
    HLUNG20023340 33.714 0
    HLUNG20033780 33.957 0
    HLUNG20084390 100 0
    IMR3220002430 3.147 0
    LIVER20028420 14.004 0
    NOVAR20000380 2.278 0
    NT2RI20023910 8.923 0
    NT2RI20054050 2.059 0
    NT2RI20091730 4.091 0
    NT2RP70044280 12.369 0
    OCBBF20020830 40.304 0
    OCBBF20125530 4.302 0
    PLACE60004630 28.618 0
    PROST20057930 14.383 0
    PROST20107820 0.892 0
    PROST20185830 33.898 0
    PUAEN20030180 12.294 0
    SMINT20121220 12.822 0
    SPLEN20002220 44.799 0
    SPLEN20008740 1.788 0
    SPLEN20054290 26.875 0
    SPLEN20128000 1.253 0
    SPLEN20157300 51.319 0
    SPLEN20176200 18.8 0
    SPLEN20179180 3.344 0
    SPLEN20211940 12.373 0
    STOMA20013890 21.183 0
    TBAES20000590 5.527 0
    TESTI20094230 59.311 0
    TESTI20184620 10.365 0
    TESTI20334410 8.049 0
    THYMU20000570 4.974 0
    THYMU20039810 1.915 0
    TRACH20007020 14.4 0
    TRACH20141240 3.786 0
    TRACH20183170 10.745 0
    ASTRO20108190 0 13.924
    ASTRO20155290 0 38.341
    BRHIP20096850 0 73.716
    FEBRA20080810 0 14.654
    MESAN20014500 0 59.68
    SMINT20028820 0 60.089
    SPLEN20162680 0 8.941
  • TABLE 12
    CloneID NOVAR TOVAR
    BGGI120006160 21.31 0
    BRHIP20005340 8.158 0
    BRHIP20191860 47.038 0
    HHDPC20001040 44.094 0
    NOVAR10000150 72.374 0
    NOVAR10000910 46.155 0
    NOVAR10001020 99.094 0
    NOVAR20000380 14.805 0
    NOVAR20003520 100 0
    THYMU20271250 4.266 0
    ASTRO20141350 0 75.66
    BRAMY20157820 0 85.296
    BRCOC20001860 0 64.79
    HLUNG20016770 0 76.536
    NT2RI20054050 0 12.229
    NTONG20090600 0 60.694
    PROST20087700 0 16.991
    PUAEN20015860 0 62.197
    SPLEN20029310 0 88.828
    TOVAR20004760 0 49.428
    TOVAR20005750 0 96.313
    TRACH20079690 0 55.276
    UTERU20004240 0 18.499
  • TABLE 13
    CloneID STOMA TSTOM
    BRACE20060840 0 65.917
    FEBRA20052910 0 77.883
    HCHON20002260 0 8.66
    HLUNG10000550 0 11.625
    NTONG20009770 0 21.112
    PROST20107820 0 5.223
    THYMU20039810 0 11.216
    TSTOM10001860 0 100
    TSTOM20001390 0 89.823
    TSTOM20003150 0 48.943
    TSTOM20005690 0 100
    ASTRO20125520 10.059 0
    BRACE20039040 17.642 0
    BRAMY20124260 42.064 0
    BRCOC20031870 10.704 0
    BRHIP20191860 13.43 0
    CTONG20128470 11.719 0
    FEBRA20037500 12.423 0
    HCHON20040020 5.343 0
    HHDPC10000830 6.661 0
    IMR3220002430 5.838 0
    KIDNE20007770 12.986 0
    NOVAR20000380 4.227 0
    NT2RI20054050 1.91 0
    NT2RI20091730 7.59 0
    PROST20130530 20.156 0
    SPLEN20149110 7.179 0
    SPLEN20157880 32.942 0
    STOMA20001830 100 0
    STOMA20005390 100 0
    STOMA20005670 100 0
    STOMA20006400 100 0
    STOMA20006780 100 0
    STOMA20006860 100 0
    STOMA20008880 100 0
    STOMA20010250 100 0
    STOMA20013890 39.303 0
    STOMA20026880 100 0
    STOMA20032890 100 0
    STOMA20034770 100 0
    STOMA20036460 100 0
    STOMA20046680 100 0
    STOMA20048520 100 0
    STOMA20048840 100 0
    STOMA20051200 85.988 0
    STOMA20056640 100 0
    STOMA20056670 100 0
    STOMA20057820 91.236 0
    STOMA20062130 100 0
    STOMA20062290 40.913 0
    STOMA20063250 100 0
    STOMA20063980 100 0
    STOMA20064470 100 0
    STOMA20067800 59.113 0
    STOMA20069040 100 0
    STOMA20072690 100 0
    STOMA20076800 100 0
    STOMA20077450 100 0
    STOMA20080500 100 0
    STOMA20083610 100 0
    STOMA20086140 100 0
    STOMA20088380 100 0
    STOMA20092530 100 0
    STOMA20092560 100 0
    STOMA20092890 39.042 0
    TESTI20184620 19.231 0
    TRACH20003590 40.588 0
    TRACH20183170 19.936 0
    PROST20083600 12.248 38.653
    TRACH20068660 6.753 21.311
  • TABLE 14
    CloneID UTERU TUTER
    DFNES10001850 0 29.393
    NT2RI20023910 0 18.073
    SMINT20144800 0 35.406
    SPLEN20162680 0 9.628
    TOVAR20004760 0 50.572
    TUTER20002830 0 100
    ASTRO20008010 1.217 0
    ASTRO20033160 10.555 0
    ASTRO20058630 4.534 0
    ASTRO20105820 20.644 0
    ASTRO20108190 3.21 0
    BRACE20039040 3.092 0
    BRACE20057190 3.542 0
    BRACE20060840 3.661 0
    BRACE20111830 7.667 0
    BRACE20223330 10.589 0
    BRAMY20266850 2.956 0
    BRAWH20113430 8.367 0
    BRAWH20126980 22.868 0
    BRCOC20031870 0.938 0
    BRCOC20107300 12.892 0
    BRCOC20121720 6.71 0
    BRCOC20155970 25.187 0
    BRHIP20105710 18.366 0
    BRHIP20191490 13.172 0
    BRHIP20207990 12.072 0
    BRHIP20217620 6.646 0
    BRHIP20222280 10.898 0
    BRHIP20238880 0.439 0
    BRHIP20249110 11.054 0
    BRSSN20018690 3.6 0
    BRTHA20000570 51.819 0
    CTONG10000940 0.464 0
    CTONG10002770 24.668 0
    CTONG20095290 7.541 0
    CTONG20099380 23.863 0
    CTONG20103480 6.336 0
    CTONG20108210 2.557 0
    CTONG20118250 10.239 0
    CTONG20129960 3.482 0
    CTONG20131560 24.668 0
    CTONG20139070 2.571 0
    CTONG20139340 8.273 0
    CTONG20143690 4.963 0
    CTONG20160560 2.372 0
    D3OST30002580 22.242 0
    FCBBF10000240 5.237 0
    FCBBF10001820 10.114 0
    FCBBF10003670 1.812 0
    FCBBF10004120 2.308 0
    FCBBF10005740 4.952 0
    FCBBF30175310 1.912 0
    FCBBF30240020 6.769 0
    FCBBF30246230 6.682 0
    FCBBF40001420 4.36 0
    FEBRA20002100 0.843 0
    FEBRA20004620 6.733 0
    FEBRA20018280 6.489 0
    FEBRA20025270 3.416 0
    FEBRA20034360 6.63 0
    FEBRA20037500 19.596 0
    FEBRA20080810 0.845 0
    FEBRA20082100 15.999 0
    FEBRA20144170 1.288 0
    FEBRA20225040 1.959 0
    HCHON20002260 0.962 0
    HCHON20007380 3.551 0
    HCHON20015980 5.796 0
    HCHON20016650 1.84 0
    HCHON20022470 3.348 0
    HCHON20040020 0.936 0
    HCHON20076500 7.263 0
    HEART20072310 11.555 0
    HHDPC20034390 1.517 0
    HLUNG10000550 1.937 0
    HLUNG20016770 4.191 0
    KIDNE20131580 21.635 0
    LIVER20028420 9.107 0
    MAMGL10000830 0.346 0
    MESAN20171520 24.337 0
    NOVAR10000150 3.622 0
    NOVAR10000910 2.31 0
    NT2NE20053580 24.761 0
    NT2NE20159740 9.111 0
    NT2NE20174920 20.127 0
    NT2RI20023160 0.956 0
    NT2RI20041880 3.425 0
    NT2RI20054050 1.004 0
    NT2RI20076290 2.404 0
    NT2RI20273230 39.625 0
    NT2RP60000770 30.666 0
    NT2RP60000850 11.032 0
    NT2RP70036880 0.881 0
    NT2RP70043480 2.695 0
    NT2RP70045590 10.166 0
    NT2RP70056750 10.406 0
    NT2RP70062230 5.039 0
    NT2RP70081610 7.488 0
    OCBBF10001750 8.591 0
    OCBBF20006770 19.428 0
    OCBBF20032460 11.672 0
    OCBBF20039250 0.994 0
    OCBBF20047570 2.956 0
    OCBBF20054760 16.727 0
    OCBBF20059560 3.386 0
    OCBBF20068490 2.41 0
    OCBBF20080050 3.787 0
    OCBBF20094240 8.655 0
    OCBBF20097720 1.404 0
    OCBBF20103130 16.359 0
    OCBBF20105570 43.708 0
    OCBBF20140640 3.258 0
    OCBBF20173980 3.068 0
    OCBBF20180120 10.043 0
    OCBBF20188730 6.611 0
    OCBBF20189560 2.019 0
    PEBLM20044520 6.439 0
    PLACE60060420 6.493 0
    PROST20087700 0.93 0
    PROST20107820 0.29 0
    PROST20149160 4.345 0
    PROST20159240 8.082 0
    PROST20176170 25.167 0
    PROST20189770 15.499 0
    PUAEN20003740 1.145 0
    PUAEN20015860 3.406 0
    SKMUS20003610 1.275 0
    SKNSH20008190 5.937 0
    SKNSH20080430 12.076 0
    SMINT20026890 51.875 0
    SMINT20029760 6.221 0
    SMINT20068010 19.209 0
    SMINT20110330 25.261 0
    SMINT20121220 4.169 0
    SPLEN20008390 10.886 0
    SPLEN20011410 2.253 0
    SPLEN20054290 17.478 0
    SPLEN20128000 0.407 0
    SPLEN20140800 5.651 0
    SPLEN20145720 7.423 0
    SPLEN20169720 4.837 0
    SPLEN20179180 3.262 0
    SPLEN20193110 57.827 0
    SPLEN20194050 3.416 0
    SPLEN20211940 8.047 0
    SPLEN20212730 17.589 0
    SPLEN20225220 1.691 0
    TBAES20000590 1.797 0
    TESTI20061110 24.59 0
    TESTI20116830 38.615 0
    TESTI20184620 3.37 0
    TESTI20208710 64.596 0
    TESTI20211240 6.816 0
    TESTI20213580 40.357 0
    TESTI20214250 4.107 0
    TESTI20334410 2.618 0
    TESTI20369130 24.204 0
    TESTI20369690 4.285 0
    TESTI20391770 4.943 0
    THYMU20039810 2.491 0
    THYMU20216840 58.853 0
    THYMU20240710 39.309 0
    TRACH20003590 3.557 0
    TRACH20032720 4.419 0
    TRACH20033230 2.123 0
    TRACH20141240 3.693 0
    TRAGH20149970 25.316 0
    UMVEN10001860 0.63 0
    UTERU20000740 62.692 0
    UTERU20004240 1.013 0
    UTERU20006290 100 0
    UTERU20020010 40.126 0
    UTERU20022940 2.165 0
    UTERU20030570 3.085 0
    UTERU20040610 100 0
    UTERU20046640 4.048 0
    UTERU20046980 100 0
    UTERU20050690 64.596 0
    UTERU20054460 24.816 0
    UTERU20055330 100 0
    UTERU20055930 4.016 0
    UTERU20056010 3.04 0
    UTERU20059050 100 0
    UTERU20061030 100 0
    UTERU20064000 15.228 0
    UTERU20064860 51.819 0
    UTERU20065930 3.522 0
    UTERU20067050 100 0
    UTERU20068990 100 0
    UTERU20070040 24.856 0
    UTERU20070810 17.449 0
    UTERU20076390 100 0
    UTERU20081300 53.896 0
    UTERU20084260 26.26 0
    UTERU20094350 12.756 0
    UTERU20095380 40.674 0
    UTERU20095400 100 0
    UTERU20097760 100 0
    UTERU20099720 16.901 0
    UTERU20101240 100 0
    UTERU20114100 100 0
    UTERU20115740 100 0
    UTERU20116570 100 0
    UTERU20118110 100 0
    UTERU20118970 100 0
    UTERU20119060 16.267 0
    UTERU20119680 100 0
    UTERU20120310 53.896 0
    UTERU20124070 29.356 0
    UTERU20126880 51.568 0
    UTERU20134910 13.929 0
    UTERU20135860 7.858 0
    UTERU20143980 100 0
    UTERU20144640 16.101 0
    UTERU20145480 39.231 0
    UTERU20146310 100 0
    UTERU20146680 39.231 0
    UTERU20150870 100 0
    UTERU20151980 100 0
    UTERU20158300 58.853 0
    UTERU20158800 100 0
    UTERU20161570 100 0
    UTERU20164260 15.158 0
    UTERU20168220 19.178 0
    UTERU20176130 12.264 0
    UTERU20176320 64.596 0
    UTERU20178100 100 0
    UTERU20179880 100 0
    UTERU20183640 53.896 0
    UTERU20185230 40.126 0
    UTERU20186740 100 0
    UTERU20188110 100 0
    UTERU20188810 100 0
    BRAWH10000930 2.2 10.279
    CT0NG20128470 2.054 38.378
    UTERU20006960 3.394 63.416
  • TABLE 15
    CloneID NTONG CTONG
    ADRGL20018300 0 22.262
    ASTRO20058630 0 14.161
    ASTRO20072210 0 34.963
    ASTRO20108190 0 5.013
    BRACE20003070 0 2.194
    BRACE20039040 0 4.829
    BRACE20060720 0 36.712
    BRACE20061050 0 39.515
    BRACE20210140 0 11.034
    BRACE20276430 0 26.828
    BRAMY20152110 0 24.194
    BRAMY20266850 0 4.616
    BRAMY20271400 0 48.032
    BRAWH10000930 0 3.436
    BRAWH20004600 0 1.137
    BRCAN20280360 0 4.497
    BRCOC20004870 0 0.54
    BRHIP20005340 0 5.1
    BRHIP20005530 0 4.786
    BRHIP20238880 0 2.741
    BRSSN20146100 0 6.65
    CTONG10000100 0 12.075
    CTONG10000220 0 100
    CTONG10000620 0 100
    CTONG10000930 0 74.021
    CTONG10000940 0 0.725
    CTONG10001650 0 100
    CTONG10002770 0 38.523
    CTONG20002180 0 100
    CTONG20004690 0 5.439
    CTONG20009770 0 100
    CTONG20014280 0 62.446
    CTONG20027090 0 4.036
    CTONG20028410 0 19.729
    CTONG20038890 0 100
    CTONG20049410 0 100
    CTONG20050280 0 25.499
    CTONG20052650 0 34.822
    CTONG20052900 0 42.764
    CTONG20075860 0 11.194
    CTONG20076130 0 16.303
    CTONG20077790 0 62.68
    CTONG20082690 0 12.672
    CTONG20085950 0 100
    CTONG20091080 0 44.201
    CTONG20091320 0 100
    CTONG20092570 0 100
    CTONG20092580 0 100
    CTONG20092680 0 100
    CTONG20092700 0 100
    CTONG20093950 0 100
    CTONG20095270 0 100
    CTONG20095290 0 11.777
    CTONG20095340 0 14.323
    CTONG20096430 0 100
    CTONG20096750 0 100
    CTONG20097660 0 100
    CTONG20098440 0 33.474
    CTONG20099380 0 37.266
    CTONG20099550 0 100
    CTONG20099630 0 38.502
    CTONG20100240 0 100
    CTONG20101480 0 100
    CTONG20103480 0 13.193
    CTONG20105080 0 15.273
    CTONG20105660 0 25.256
    CTONG20106230 0 100
    CTONG20106520 0 29.937
    CTONG20108210 0 2.662
    CTONG20114290 0 100
    CTONG20114740 0 100
    CTONG20118150 0 100
    CTONG20118250 0 15.991
    CTONG20119200 0 100
    CTONG20120770 0 100
    CTONG20121010 0 29.404
    CTONG20121580 0 33.983
    CTONG20124010 0 7.835
    CTONG20124220 0 69.076
    CTONG20124470 0 100
    CTONG20124730 0 100
    CTONG20125540 0 100
    CTONG20125640 0 7.359
    CTONG20126070 0 3.221
    CTONG20127450 0 10.331
    CTONG20128470 0 9.622
    CTONG20129960 0 32.63
    CTONG20131490 0 24.817
    CTONG20131560 0 38.523
    CTONG20132220 0 6.999
    CTONG20133390 0 100
    CTONG20133480 0 10.246
    CTONG20133520 0 50.616
    CTONG20136300 0 100
    CTONG20138030 0 100
    CTONG20139070 0 8.031
    CTONG20139340 0 12.919
    CTONG20139860 0 100
    CTONG20140320 0 100
    CTONG20140580 0 100
    CTONG20141650 0 8.968
    CTONG20146300 0 100
    CTONG20147050 0 34.963
    CTONG20149460 0 100
    CTONG20149950 0 100
    CTONG20153300 0 52.97
    CTONG20153580 0 74.021
    CTONG20155180 0 24.734
    CTONG20155400 0 100
    CTONG20156780 0 62.446
    CTONG20158040 0 100
    CTONG20158150 0 16.385
    CTONG20158660 0 100
    CTONG20159530 0 100
    CTONG20160560 0 3.704
    CTONG20161850 0 19.368
    CTONG20162170 0 100
    CTONG20163550 0 100
    CTONG20164990 0 65.066
    CTONG20165050 0 33.474
    CTONG20186320 0 14.897
    CTONG20200310 0 100
    CTONG20265130 0 100
    CTONG20267700 0 100
    CTONG20273610 0 100
    FCBBF10000240 0 12.268
    FCBBF10005740 0 3.866
    FCBBF30123470 0 4.088
    FCBBF30233680 0 9.14
    FEBRA20025270 0 5.334
    FEBRA20037500 0 6.8
    HCHON20002260 0 1.502
    HCHON20007380 0 5.546
    HCHON20007510 0 6.65
    HCHON20015350 0 17.176
    HCHON20040020 0 1.462
    HHDPC20034390 0 0.474
    HLUNG10000550 0 2.016
    KIDNE20002520 0 3.184
    KIDNE20009470 0 9.415
    KIDNE20115080 0 34.822
    KIDNE20127100 0 35.274
    LIVER20028420 0 3.556
    MESAN20029400 0 5.924
    NT2RI20023160 0 1.493
    NT2RI20023910 0 1.51
    NT2RI20091730 0 4.155
    NT2RP70043480 0 4.209
    NT2RP70078420 0 3.572
    NT2RP70081610 0 11.694
    OCBBF20006770 0 30.34
    OCBBF20059560 0 5.287
    OCBBF20073540 0 1.871
    OCBBF20094240 0 13.516
    OCBBF20108580 0 12.407
    PEBLM20044520 0 15.083
    PEBLM20071880 0 16.259
    PROST20107820 0 0.453
    PUAEN20030180 0 6.243
    SKNSH20008190 0 4.636
    SMINT20023280 0 34.547
    SMINT20089170 0 20.839
    SPLEN20179180 0 5.094
    TESTI20094020 0 17.075
    TESTI20094230 0 30.119
    TESTI20152460 0 22.051
    TESTI20184620 0 5.263
    TESTI20211240 0 10.645
    TESTI20442760 0 8.832
    THYMU20039810 0 0.973
    TRACH20028030 0 11.644
    TRACH20141240 0 1.923
    TSTOM20003150 0 4.245
    UTERU20004240 0 1.582
    UTERU20055930 0 2.091
    UTERU20065930 0 2.75
    UTERU20119060 0 12.702
    UTERU20124070 0 45.844
    BRACE20039440 34.336 0
    BRACE20068590 74.88 0
    FCBBF30018550 20.639 0
    IMR3220002430 6.323 0
    KIDNE20028830 16.715 0
    NT2RI20028470 9.251 0
    NT2RI20054050 2.069 0
    NT2RI20086220 23.258 0
    NTONG20009770 7.245 0
    NTONG20013620 25.727 0
    NTONG20028070 86.921 0
    NTONG20029480 32.729 0
    NTONG20029700 100 0
    NTONG20046140 43.643 0
    NTONG20048060 51.123 0
    NTONG20049910 100 0
    NTONG20050620 100 0
    NTONG20050860 100 0
    NTONG20051530 58.314 0
    NTONG20052650 100 0
    NTONG20056570 100 0
    NTONG20061870 100 0
    NTONG20063010 40.505 0
    NTONG20064400 100 0
    NTONG20064840 31.857 0
    NTONG20065010 100 0
    NTONG20066460 100 0
    NTONG20067090 66.789 0
    NTONG20067830 20.865 0
    NTONG20070200 100 0
    NTONG20070340 52.247 0
    NTONG20075220 100 0
    NTONG20076930 51.858 0
    NTONG20077560 49.744 0
    NTONG20083650 100 0
    NTONG20088620 100 0
    NTONG20090600 20.536 0
    NTONG20090680 100 0
    NTONG20092290 100 0
    NTONG20092330 100 0
    OCBBF20068490 14.895 0
    SKMUS20001980 23.281 0
    SMINT20138900 67.622 0
    SPLEN20008390 67.269 0
    SPLEN20162680 3.184 0
    UTERU20134910 86.071 0
    ASTRO20155290 13.655 3.451
    FEBRA20080810 10.438 1.319
    NT2RP70032610 10.013 27.835
    NT2RP70036880 5.442 16.504
    NTONG20015870 17.552 0.554
    OCBBF20188730 10.213 2.581
    SMINT20122910 33.985 8.589
    SPLEN20099700 37.585 9.499
  • TABLE 16
    CloneID FCBBF FEBRA OCBBF BRACE BRALZ BRAMY BRAWH BRCAN BRCOC BRHIP BRSSN BRSTN BRTHA
    3NB6910001910 0 0 0 0 0 0 6.122 0 0 6.426 0 0 0
    ADRGL- 0 0 0 8.483 0 0 0 0 0 0 0 0 0
    20018300
    ASTRO20001410 0 0 0 0 0 3.06 0 0 0 0 0 0 0
    ASTRO20033160 0 0 0 2.094 0 0 2.95 0 0 0 0 0 0
    ASTRO20058630 0 0 0 0 0 0 7.603 0 0 0 0 0 0
    ASTRO20064750 0 0 0 0 0 7.505 0 0 0 0 0 0 16.519
    ASTRO20100720 0 0 0 0 0 0 0 39.838 0 0 0 0 0
    ASTRO20141350 0 0 0 0 0 0 0 0 12.305 0 0 0 0
    ASTRO20145760 0 0 0 0 0 11.388 0 0 0 0 42.066 0 0
    ASTRO20181690 0 0 0 0 0 0.952 0 2.167 0 1.927 0 0 0
    BGGI120006160 0 0 0 1.269 0 0.901 0 2.051 0 0 0 3.224 0.991
    BRACE20006400 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20011070 0 0 0 10.447 53.184 0 0 0 0 0 0 0 0
    BRACE20019540 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20027620 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20037660 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20038000 0 0 0 38.906 0 0 0 0 0 0 0 0 30.394
    BRACE20038470 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20038480 0 0 0 38.787 0 0 0 0 0 0 0 0 0
    BRACE20038850 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20039440 0 0 0 0.367 0 2.086 0.518 1.188 1.834 0 1.927 1.867 0
    BRACE20039540 0 0 0 16.746 0 0 0 0 0 0 0 0 0
    BRACE20050900 0 0 0 52.057 0 0 0 0 0 0 0 0 0
    BRACE20051380 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20051690 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20052160 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20053280 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20053480 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20053630 0 0 0 10.086 0 0 0 0 0 0 0 0 0
    BRACE20054500 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20055180 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20057420 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20057620 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20057730 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20058580 0 0 0 14.668 0 0 41.331 0 0 21.084 0 0 22.917
    BRACE20058810 0 0 0 100 0 0 0 0 0 0 0 0 0
  • TABLE 17
    BRACE20060840 0 0 0 2.179 0 3.093 0 14.084 0 0 0 11.067 0
    BRACE20060890 0 0 0 54.983 0 0 16.309 0 0 0 0 0 0
    BRACE20061050 0 0 0 15.058 0 0 0 0 0 0 0 0 0
    BRACE20061740 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20062400 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20062740 0 0 0 41.329 0 58.671 0 0 0 0 0 0 0
    BRACE20063630 0 0 0 26.312 0 9.338 0 21.263 0 0 0 0 0
    BRACE20063780 0 0 0 38.787 0 0 0 0 0 0 0 0 0
    BRACE20063800 0 0 0 58.183 0 0 0 0 0 41.817 0 0 0
    BRACE20063930 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20064880 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20068590 0 0 0 7.211 0 0 0 0 0 0 0 0 11.267
    BRACE20069090 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20081720 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20082950 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20096200 0 0 0 13.619 0 0 0 0 0 0 0 0 0
    BRACE20096540 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20097320 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20101700 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20101710 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20106840 0 0 0 38.787 0 0 0 0 0 0 0 0 0
    BRACE20107530 0 0 0 13.239 0 0 0 0 66.077 0 0 0 20.684
    BRACE20108130 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20108880 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20109370 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20109830 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20114780 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20115450 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20115920 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20116110 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20116460 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20118380 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20121850 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20141080 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20142320 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20147800 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20148210 0 0 0 100 0 0 0 0 0 0 0 0 0
  • TABLE 18
    BRACE20148240 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20150310 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20151320 0 0 0 11.694 0 0 0 0 58.366 0 0 0 0
    BRACE20152870 0 0 0 1.63 0 0 0 0 8.135 0 0 0 2.547
    BRACE20153680 0 0 0 41.512 0 0 58.488 0 0 0 0 0 0
    BRACE20154120 0 0 0 17.282 0 0 12.174 0 0 0 0 0 0
    BRACE20163150 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20163350 0 0 0 9.897 0 0 0 0 0 0 0 0 0
    BRACE20165830 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20171240 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20172980 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20175870 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20177200 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20179340 0 0 0 13.12 0 0 0 0 0 0 0 33.326 0
    BRACE20185680 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20188470 0 0 0 13.846 0 0 39.016 0 0 0 0 0 21.634
    BRACE20190040 0 0 0 39.025 0 0 0 0 0 0 0 0 60.975
    BRACE20190440 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20192440 0 0 0 28.977 0 0 0 0 0 0 0 0 0
    BRACE20195100 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20201570 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20220300 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20223280 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20223330 0 0 0 12.602 0 0 17.756 0 0 18.115 0 0 19.69
    BRACE20224480 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20224500 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20228480 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20229280 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20230700 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20232840 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20235400 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20237270 0 0 0 14.013 0 0 0 0 0 0 0 0 0
    BRACE20238000 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20240740 0 0 0 45.981 0 0 0 0 0 0 0 0 0
    BRACE20248260 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20253160 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20253330 0 0 0 100 0 0 0 0 0 0 0 0 0
  • TABLE 19
    BRACE20257100 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20262930 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20262940 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20266750 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20267250 0 0 0 13.014 0 0 0 0 0 0 0 0 0
    BRACE20269200 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20269710 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20273890 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20274080 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20283920 0 0 0 7.236 0 0 0 0 18.058 0 37.945 36.76 0
    BRACE20284100 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20286360 0 0 0 37.993 48.354 0 0 0 0 13.653 0 0 0
    BRACE20287410 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRALZ20013500 0 0 0 0 100 0 0 0 0 0 0 0 0
    BRALZ20014450 0 0 0 0 100 0 0 0 0 0 0 0 0
    BRALZ20017430 0 0 0 0 100 0 0 0 0 0 0 0 0
    BRALZ20018340 0 0 0 0 76.517 0 0 0 0 0 0 0 23.483
    BRALZ20054710 0 0 0 0 100 0 0 0 0 0 0 0 0
    BRALZ20058880 0 0 0 0 100 0 0 0 0 0 0 0 0
    BRALZ20059500 0 0 0 0 100 0 0 0 0 0 0 0 0
    BRALZ20064740 0 0 0 0 100 0 0 0 0 0 0 0 0
    BRALZ20065600 0 0 0 0 100 0 0 0 0 0 0 0 0
    BRALZ20069760 0 0 0 0 100 0 0 0 0 0 0 0 0
    BRALZ20073760 0 0 0 0 100 0 0 0 0 0 0 0 0
    BRALZ20075450 0 0 0 0 100 0 0 0 0 0 0 0 0
    BRALZ20075760 0 0 0 0 100 0 0 0 0 0 0 0 0
    BRALZ20077900 0 0 0 0 100 0 0 0 0 0 0 0 0
    BRALZ20077930 0 0 0 0 100 0 0 0 0 0 0 0 0
    BRALZ20080310 0 0 0 0 100 0 0 0 0 0 0 0 0
    BRALZ20088690 0 0 0 0 100 0 0 0 0 0 0 0 0
    BRAMY10001300 0 0 0 0 0 12.137 0 0 0 0 0 0 0
    BRAMY10001570 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20000520 0 0 0 0 39.13 21.823 0 0 0 0 0 39.047 0
    BRAMY20000860 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20002770 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20004110 0 0 0 4.399 0 18.735 0 0 0 12.647 23.069 0 0
    BRAMY20011140 0 0 0 0 0 100 0 0 0 0 0 0 0
  • TABLE 20
    BRAMY20025840 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20039260 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20045240 0 0 0 0 0 21.841 0 0 0 0 0 78.159 0
    BRAMY20054880 0 0 0 8.088 0 22.964 0 0 40.37 11.626 0 0 0
    BRAMY20060920 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20063970 0 0 0 0 0 2.83 0 6.443 0 2.865 10.452 0 0
    BRAMY20071850 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20102080 0 0 0 0 0 36.63 0 0 0 0 0 0 0
    BRAMY20104640 0 0 0 15.639 0 33.302 11.017 0 0 0 0 0 0
    BRAMY20110640 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20111960 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20116790 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20121190 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20121620 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20124260 0 0 0 0 0 6.228 0 0 0 0 0 0 0
    BRAMY20134140 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20135900 0 0 0 0 0 43.537 0 0 0 0 0 0 0
    BRAMY20136210 0 0 0 0 0 29.482 0 0 0 0 0 0 0
    BRAMY20137560 0 0 0 0 0 19.026 0 0 0 0 0 0 0
    BRAMY20144620 0 0 0 0 0 49.688 0 0 0 50.312 0 0 0
    BRAMY20147540 0 0 0 5.965 5.061 4.234 5.603 12.854 9.924 27.152 10.427 0 12.427
    BRAMY20148130 0 0 0 0 0 19.441 0 0 0 0 0 0 0
    BRAMY20152110 0 0 0 0 0 13.088 0 0 0 0 0 0 0
    BRAMY20153110 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20157820 0 0 0 0 0 7.891 0 0 0 0 0 0 0
    BRAMY20160700 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20163250 0 0 0 0 0 3.796 11.304 0 0 3.844 0 0 4.178
    BRAMY20163270 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20167060 0 0 0 0 0 4.994 0 0 0 0 0 0 0
    BRAMY20167710 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20168920 0 0 0 10.306 0 14.63 14.52 0 0 44.442 0 0 16.102
    BRAMY20170140 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20174550 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20178640 0 0 0 0 0 13.922 0 0 0 14.097 51.427 0 0
    BRAMY20181220 0 0 0 0 0 12.783 0 0 0 0 0 0 0
    BRAMY20182730 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20183080 0 0 0 0 0 100 0 0 0 0 0 0 0
  • TABLE 21
    BRAMY20184670 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20195090 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20204450 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20205740 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20210400 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20211390 0 0 0 0 0 25.787 0 0 0 0 0 0 0
    BRAMY20211420 0 0 0 38.011 0 26.981 0 0 0 0 0 0 0
    BRAMY20213100 0 0 0 0 0 12.518 0 0 0 0 0 0 0
    BRAMY20215230 0 0 0 0 0 21.367 0 0 0 0 0 0 0
    BRAMY20217460 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20218250 0 0 0 0 0 66.389 0 0 0 33.611 0 0 0
    BRAMY20218670 0 0 0 25.113 0 35.65 0 0 0 0 0 0 39.237
    BRAMY20229800 0 0 0 0 0 15.383 30.533 0 54.084 0 0 0 0
    BRAMY20229840 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20230600 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20231720 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20240040 0 0 0 1.963 0 2.787 0 6.346 9.799 0 0 0 3.067
    BRAMY20245300 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20247110 0 0 0 0 0 12.354 0 0 43.436 0 0 44.21 0
    BRAMY20247280 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20248490 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20250240 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20250320 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20252180 0 0 0 0 0 100 0 0 9 0 0 0 0
    BRAMY20252720 0 0 0 0 0 47.605 0 0 0 0 0 0 52.395
    BRAMY20260910 0 0 0 0 0 100 0 0 9 0 0 0 0
    BRAMY20261680 0 0 0 0 0 32.33 32.087 0 9 0 0 0 35.583
    BRAMY20266850 0 0 0 0 0 2.497 0 0 0 0 0 0 0
    BRAMY20267130 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20268990 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20270730 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20271400 0 0 0 0 0 51.968 0 0 0 0 0 0 0
    BRAMY20273960 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20277140 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20277170 0 0 0 0 0 16.593 20.585 0 0 12.601 0 0 50.221
    BRAMY20280720 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20284910 0 0 0 0 0 36.15 0 0 0 0 0 0 0
  • TABLE 22
    BRAMY20285160 0 0 0 0 0 3.974 0 0 0 0 14.68 0 0
    BRAMY20285930 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20286820 0 0 0 0 0 21.396 0 0 0 0 0 0 0
    BRAWH20002320 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20012390 0 0 0 0 0 0 7.296 0 0 0 27.156 0 8.091
    BRAWH20014920 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20015350 0 0 0 0 5.352 6.965 1.975 15.859 5.247 10.075 16.539 14.243 10.951
    BRAWH20015890 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20016660 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20016860 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20017010 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20018730 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20028110 0 0 0 0 31.162 17.379 8.624 0 0 17.598 0 0 9.564
    BRAWH20029630 0 0 0 8.469 0 0 11.932 0 0 0 0 0 0
    BRAWH20064050 0 0 0 0 0 0 12.977 0 0 13.24 0 0 0
    BRAWH20075700 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20096780 0 0 0 0 0 0 21.269 0 0 0 0 0 0
    BRAWH20100690 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20101360 0 0 0 0 0 26.605 26.404 0 0 0 0 0 0
    BRAWH20103180 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20105840 0 0 0 0 0 0 30.356 69.644 0 0 0 0 0
    BRAWH20106180 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20107540 0 0 0 7.94 0 0 11.186 0 0 0 0 40.334 0
    BRAWH20110660 0 0 0 0 0 0 21.178 0 0 0 78.822 0 0
    BRAWH20110790 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20110960 0 0 0 0 0 0 54.53 0 0 0 0 0 0
    BRAWH20111550 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20112940 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20114000 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20117950 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20118230 0 0 0 0 0 0 21.626 0 0 0 0 0 0
    BRAWH20122580 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20125380 0 0 0 0 0 0 10.145 0 0 0 18.88 0 0
    BRAWH20126190 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20126980 0 0 0 0 0 57.958 19.174 0 0 0 0 0 0
    BRAWH20132190 0 0 0 0 35.004 9.761 19.375 0 0 0 0 0 0
    BRAWH20137480 0 0 0 0 0 8.068 2.669 6.123 9.455 2.723 9.934 0 2.96
  • TABLE 23
    BRAWH20138660 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20139410 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20142340 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20147290 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20149340 0 0 0 0 0 0 35.975 0 0 0 0 0 0
    BRAWH20155950 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20158530 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20160280 0 0 0 0 0 50.189 49.811 0 0 0 0 0 0
    BRAWH20162690 0 0 0 0.936 0 1.328 1.318 3.025 4.67 0 4.907 0 0
    BRAWH20166790 0 0 0 6.839 0 0 9.636 0 0 0 0 0 0
    BRAWH20171030 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20173050 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRAWH20182060 0 0 0 0 0 0 11.051 0 0 11.275 0 0 36.766
    BRAWH20185060 0 0 0 0 0 0 100 0 0 0 0 0 0
    BRCAN10001490 0 0 0 0 0 0 0 56.874 0 0 0 0 0
    BRCAN20003460 0 0 0 0 0 0 0 100 0 0 0 0 0
    BRCAN20006200 0 0 0 0 0 0 0 100 0 0 0 0 0
    BRCAN20006390 0 0 0 0 0 0 0 38.481 0 0 0 0 0
    BRCAN20054490 0 0 0 0 0 0 0 100 0 0 0 0 0
    BRCAN20060190 0 0 0 2.666 13.575 0 0 25.857 26.617 3.833 0 13.546 0
    BRCAN20064010 0 0 0 0 0 22.844 0 52.014 0 0 0 0 25.142
    BRCAN20071190 0 0 0 0 0 0 0 38.885 0 0 0 61.115 0
    BRCAN20091560 0 0 0 0 0 0 0 100 0 0 0 0 0
    BRCAN20103740 0 0 0 0 0 30.516 0 69.484 0 0 0 0 0
    BRCAN20124080 0 0 0 0 0 0 0 100 0 0 0 0 0
    BRCAN20126130 0 0 0 0 0 0 0 100 0 0 0 0 0
    BRCAN20143700 0 0 0 0 0 0 0 100 0 0 0 0 0
    BRCAN20147880 0 0 0 0 0 0 0 100 0 0 0 0 0
    BRCAN20216690 0 0 0 0 0 0 0 100 0 0 0 0 0
    BRCAN20224720 0 0 0 0 0 0 0 100 0 0 0 0 0
    BRCAN20237240 0 0 0 0 0 0 0 100 0 0 0 0 0
    BRCAN20263400 0 0 0 10.726 54.604 0 0 34.67 0 0 0 0 0
    BRCAN20273100 0 0 0 0 0 0 0 100 0 0 0 0 0
    BRCAN20273340 0 0 0 0 0 30.516 0 69.484 0 0 0 0 0
    BRCAN20273550 0 0 0 0 0 0 0 100 0 0 0 0 0
    BRCAN20275130 0 0 0 0 0 0 0 100 0 0 0 0 0
    BRCAN20279700 0 0 0 0 0 0 0 100 0 0 0 0 0
  • TABLE 24
    BRCAN20280210 0 0 0 0 0 0 0 100 0 0 0 0 0
    BRCAN20280400 0 0 0 0 0 0 0 60.666 0 0 0 0 0
    BRCAN20283190 0 0 0 0 0 0 0 29.858 0 0 48.439 0 0
    BRCAN20283380 0 0 0 0 0 0 0 100 0 0 0 0 0
    BRCAN20284600 0 0 0 0 0 0 0 100 0 0 0 0 0
    BRCAN20285450 0 0 0 0 0 0 0 38.885 0 0 0 61.115 0
    BRCOC10000870 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20001860 0 0 0 4.222 0 0 0 0 10.537 0 0 0 0
    BRCOC20004040 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20004870 0 0 0 0 0 0 0 0.665 1.026 0 0 0 0.643
    BRCOC20006370 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20008160 0 0 0 0 0 0 22.014 0 77.986 0 0 0 0
    BRCOC20008500 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20020850 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20021550 0 0 0 0 0 0 0 0 75.977 0 0 0 0
    BRCOC20023230 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20026640 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20027510 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20031000 0 0 0 16.691 0 0 0 0 83.309 0 0 0 0
    BRCOC20031250 0 0 0 0 0 0 0 0 20.131 0 0 0 0
    BRCOC20031870 0 0 0 0.558 0 0 0.786 1.804 2.786 0 5.854 2.836 0
    BRCOC20035130 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20037320 0 0 0 0 0 0 0 0 75.977 0 0 0 0
    BRCOC20037400 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20041750 0 0 0 0 0 0 0 0 34.465 0 0 0 0
    BRCOC20055420 0 0 0 0 0 17.805 0 0 62.599 0 0 0 19.596
    BRCOC20059510 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20077690 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20090520 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20091960 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20093800 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20099370 0 0 0 0 0 16.189 0 0 56.917 16.392 0 0 0
    BRCOC20101230 0 0 0 0 0 0 0 2.513 3.881 0 0 0 0
    BRCOC20107300 0 0 0 0 0 0 0 0 38.292 0 0 0 11.987
    BRCOC20110100 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20114180 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20117690 0 0 0 0 0 0 0 0 100 0 0 0 0
  • TABLE 25
    BRCOC20119960 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20121720 0 0 0 1.996 0 0 0 0 9.965 2.87 0 0 3.119
    BRCOC20122290 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20128130 0 0 0 0 0 0 0 39.306 60.694 0 0 0 0
    BRCOC20134480 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20135730 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20136750 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20144000 0 0 0 0 0 0 0 0 59.512 0 0 0 0
    BRCOC20147480 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20148330 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20155970 0 0 0 0 0 0 0 0 74.813 0 0 0 0
    BRCOC20158240 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRCOC20176520 0 0 0 0 0 0 0 0 48.902 0 0 0 0
    BRCOC20178560 0 0 0 0 0 0 0 0 100 0 0 0 0
    BRHIP10001290 0 0 0 0 0 49.688 0 0 0 50.312 0 0 0
    BRHIP20000870 0 0 0 0 23.781 6.632 0 0 0 13.429 24.496 0 7.299
    BRHIP20001630 0 0 0 0 0 0 37.398 0 0 38.155 0 0 0
    BRHIP20096170 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20096850 0 0 0 0 0 0 7.124 0 0 7.269 0 0 7.901
    BRHIP20103090 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20104440 0 0 0 0 0 0 0 0 0 47.917 0 0 52.083
    BRHIP20105710 0 0 0 21.859 0 15.515 0 0 0 31.42 0 0 0
    BRHIP20106100 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20107440 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20111200 0 0 0 32.686 0 7.734 15.351 0 0 15.661 28.568 0 0
    BRHIP20115080 0 0 0 0 0 0 0 0 0 22.032 0 0 23.948
    BRHIP20115760 0 0 0 13.607 0 0 0 0 0 19.559 0 0 0
    BRHIP20118380 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20118910 0 0 0 0 0 0 0 0 0 60.949 0 0 0
    BRHIP20119330 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20121410 0 0 0 0 0 0 0 0 0 47.917 0 0 52.083
    BRHIP20123140 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20129720 0 0 0 0 0 0 0 0 0 47.917 0 0 52.083
    BRHIP20132860 0 0 0 0 0 0 0 0 0 17.468 0 0 0
    BRHIP20135100 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20137230 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20139720 0 0 0 0 0 0 0 0 0 100 0 0 0
  • TABLE 26
    BRHIP20140630 0 0 0 0 0 0 0 0 0 36.967 0 0 0
    BRHIP20142850 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20143730 0 0 0 0 0 0 0 0 0 34.432 0 0 37.426
    BRHIP20143860 0 0 0 0 0 0 0 0 0 55.026 0 0 0
    BRHIP20149540 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20153560 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20153600 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20167880 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20169680 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20169900 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20170100 0 0 0 0 0 0 0 0 0 14.025 0 0 0
    BRHIP20173150 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20174040 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20175420 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20180140 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20183690 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20186120 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20186500 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20189980 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20190070 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20191490 0 0 0 0 0 0 0 0 0 11.267 0 0 0
    BRHIP20191770 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20194940 0 0 0 25.807 0 0 0 0 0 74.193 0 0 0
    BRHIP20195890 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20196410 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20205090 0 0 0 0 0 0 0 0 0 19.104 0 0 0
    BRHIP20207430 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20207990 0 0 0 3.592 0 15.298 5.061 0 0 36.143 0 0 5.612
    BRHIP20208420 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20208590 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20227080 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20230710 0 0 0 0 0 49.688 0 0 0 50.312 0 0 0
    BRHIP20232290 0 0 0 0 0 0 0 0 0 15.312 0 0 0
    BRHIP20233090 0 0 0 8.28 0 0 11.666 0 0 23.804 0 0 0
    BRHIP20234380 0 0 0 0 0 0 0 0 0 26.026 0 0 0
    BRHIP20236950 0 0 0 0 0 0 0 0 0 36.438 0 0 0
    BRHIP20238600 0 0 0 0 0 0 0 0 0 100 0 0 0
  • TABLE 27
    BRHIP20238690 0 0 0 0 0 0 0 0 0 36.661 0 0 39.849
    BRHIP20240460 0 0 0 0 0 0 0 0 0 31.291 0 0 0
    BRHIP20243470 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20249110 0 0 0 0 0 0 0 0 0 9.456 0 0 0
    BRHIP20252450 0 0 0 0 0 0 0 0 0 47.666 0 0 0
    BRHIP20253660 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20277620 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20283030 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20284800 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP20285830 0 0 0 0 0 0 0 0 0 12.691 0 0 0
    BRHIP20285930 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRHIP30004880 0 0 0 0 0 0 0 0 0 100 0 0 0
    BRSSN10000920 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20013420 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20014260 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20015030 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20015790 0 0 0 0 0 0 0 0 0 0 50.137 0 0
    BRSSN20018690 0 0 0 2.142 0 0 0 6.925 0 0 11.235 0 6.695
    BRSSN20028570 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20038200 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20038410 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20039370 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20043040 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20046570 0 0 0 0 0 0 0 0 0 0 85.061 0 0
    BRSSN20046790 0 0 0 0 0 0 0 0 0 0 56.646 0 16.878
    BRSSN20046860 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20066110 0 0 0 0 0 21.304 0 0 0 0 78.696 0 0
    BRSSN20097020 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20101100 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20105870 0 0 0 16.015 0 0 0 0 0 0 83.985 0 0
    BRSSN20105960 0 0 0 0 43.31 12.077 0 0 0 0 44.612 0 0
    BRSSN20108300 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20120810 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20121030 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20137020 0 0 0 0 0 0 0 0 33.606 0 35.308 0 0
    BRSSN20142940 0 0 0 0 0 0 0 0 0 0 34.652 0 0
    BRSSN20146100 0 0 0 5.068 0 3.597 0 0 0 10.927 13.288 0 11.878
  • TABLE 28
    BRSSN20151990 0 0 0 16.015 0 0 0 0 0 0 83.985 0 0
    BRSSN20159070 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20159820 0 0 0 0 0 0 0 0 0 0 60.467 0 0
    BRSSN20169050 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20176820 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20177570 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSSN20187310 0 0 0 0 0 0 0 0 0 0 100 0 0
    BRSTN20000580 0 0 0 3.424 0 2.431 0 33.205 25.637 0 8.978 17.396 0
    BRSTN20005360 0 0 0 0 0 0 0 0 0 22.055 0 77.945 0
    BRTHA20000570 0 0 0 0 0 0 0 0 0 0 0 0 48.181
    BRTHA20004740 0 0 0 0 0 0 0 0 0 0 0 0 100
    BRTHA20046290 0 0 0 0 0 0 0 0 0 0 0 0 100
    BRTHA20046390 0 0 0 0 0 0 0 0 0 0 0 0 100
    BRTHA20046420 0 0 0 0 0 0 0 0 0 0 0 0 100
    CD34C30001250 0 0 0 0 0 0 0 0 0 2.372 0 0 0
    CD34C30004240 0 0 0 0 0 0 0 0 0 2.336 0 0 0
    CTONG10000100 0 0 0 0 0 6.532 0 0 0 0 0 0 7.19
    CTONG20004690 0 0 0 0 0 0 0 0 10.345 0 0 0 0
    CTONG20027090 0 0 0 1.538 0 0 0 0 0 0 0 0 0
    CTONG20050280 0 0 0 14.575 0 0 6.845 0 0 0 0 0 7.591
    CTONG20076130 0 0 0 0 0 0 0 0 0 0 0 0 9.707
    CTONG20077790 0 0 0 0 0 0 0 0 0 0 0 0 37.32
    CTONG20095290 0 0 0 0 0 0 0 14.506 0 0 0 0 0
    CTONG20095340 0 0 0 16.375 0 0 0 0 0 23.537 28.623 0 8.528
    CTONG20099380 0 0 0 0 0 0 0 0 0 0 0 0 22.188
    CTONG20106520 0 0 0 0 0 0 0 0 0 0 0 0 35.648
    CTONG20118250 0 0 0 6.093 0 0 0 0 0 0 0 0 0
    CTONG20121010 0 0 0 0 0 15.907 0 0 0 0 0 0 0
    CTONG20127450 0 0 0 0 0 0 0 0 0 5.659 0 0 0
    CTONG20128470 0 0 0 1.222 0 0 3.444 0 0 0 0 0 1.91
    CTONG20141650 0 0 0 0 0 0 0 0 0 0 0 0 5.339
    CTONG20143690 0 0 0 2.954 0 0 0 0 0 4.246 0 0 0
    CTONG20153300 0 0 0 0 0 0 28.439 0 0 0 0 0 0
    CTONG20155180 0 0 0 0 0 0 26.559 0 0 0 0 0 0
    CTONG20158150 0 0 0 6.244 0 0 8.797 0 0 0 0 0 0
    CTONG20161850 0 0 0 3.69 0 2.619 0 0 0 0 0 0 0
    CTONG20164990 0 0 0 0 0 0 34.934 0 0 0 0 0 0
  • TABLE 29
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    D3OST10002700 0 0 0 0 0 7.81 0 0 9.153 0 0 0 0
    D6OST20003580 0 0 0 0 0 1.432 0 0 0 0 0 0 1.576
    D9OST20000310 0 0 0 0 0 0 0 0 16.736 0 0 0 0
    D9OST20035800 0 0 0 0 0 6.953 0 0 0 0 0 0 0
    DFNES20010910 0 0 0 0 0 0 0 19.689 0 0 0 0 0
    DFNES20071130 0 0 0 0 0 0 0 0 0 0 0 0 7.411
    HCHON20002260 0 0 0 1.431 0 0 0.403 0.925 2.857 0.411 0 1.454 0
    HCHON20003220 0 0 0 0 0 0 10.98 0 0 0 0 0 0
    HCHON20010990 0 0 0 0 0 0 0 0 0 2.783 0 0 3.025
    HCHON20015350 0 0 0 0 0 0 18.444 0 0 0 0 0 0
    HCHON20022470 0 0 0 1.993 10.144 0 5.615 0 9.945 2.864 0 0 9.34
    HCHON20067220 0 0 0 0 0 0 0 0 35.892 0 0 0 0
    HCHON20067700 0 0 0 0 0 0 2.822 0 0 0 0 0 0
    HEART20003060 0 0 0 9.616 0 0 0 0 0 0 0 0 0
    HEART20005410 0 0 0 0 0 0 0 3.07 4.74 0 0 0 0
    HEART20061950 0 0 0 0 0 0 0 0 0 9.669 0 0 0
    HEART20090000 0 0 0 7.336 0 0 0 23.712 0 0 0 0 0
    HHDPC10000650 0 0 0 0 0 0 0 0 0 27.988 0 0 0
    HHDPC20057940 0 0 0 0 0 8.015 0 0 0 8.116 0 0 8.821
    HLUNG20033780 0 0 0 6.571 0 0 0 0 0 0 0 0 0
    KIDNE20011170 0 0 0 0 0 0 22.29 0 0 0 0 0 0
    KIDNE20027250 0 0 0 7.303 0 0 10.289 23.605 0 0 0 0 11.41
    KIDNE20104300 0 0 0 0 0 0 0 21.878 0 0 0 0 10.575
    KIDNE20107500 0 0 0 0 0 0 0 0 0 0 0 0 11.811
    KIDNE20122910 0 0 0 16.915 0 0 0 0 0 0 0 0 0
    KIDNE20127100 0 0 0 0 0 0 0 0 0 0 0 0 10.501
    KIDNE20180710 0 0 0 0 50.895 0 0 0 0 0 0 0 0
    LIVER10001260 0 0 0 0 0 0 0 0 0 0 28.534 0 0
    LIVER20064100 0 0 0 0 0 0 0 0 0 0 0 0 11.342
    LIVER20087510 0 0 0 0 0 0 0 0 0 0 0 0 9.629
    MAMGL10000830 0 0 0 0.206 0 0 0 0 0 0.296 0 0 0.321
    MESAN20031900 0 0 0 0 0 0 0 0 0 0 0 0 19.624
    MESAN20036460 0 0 0 0 0 0 0 0 0 0 0 0 23.021
    MESAN20106640 0 0 0 6.16 0 0 0 19.91 0 0 0 0 9.624
    MESAN20164090 0 0 0 0 0 0 0 38.222 0 0 0 0 0
    NOVAR10000150 0 0 0 0 0 0 0 0 10.757 0 0 0 0
  • TABLE 30
    NOVAR20000380 0 0 0 3.968 15.711 0.626 1.242 4.275 6.602 0 9.248 17.918 0
    NT2NE20010400 0 0 0 11.003 0 15.621 0 0 0 0 0 0 17.192
    NT2NE20010490 0 0 0 0 0 0 0 0 0 0 0 31.686 0
    NT2NE20021620 0 0 0 0 0 0 0 0 0 0 45.501 0 0
    NT2NE20122430 0 0 0 0 0 0 0 0 0 0 0 0 23.43
    NT2NE20125050 0 0 0 13.014 0 0 0 0 0 0 0 0 0
    NT2NE20174920 0 0 0 0 0 0 0 0 0 0 0 0 18.714
    NT2RI20001330 0 0 0 1.819 0 0 0 0 0 0 0 0 0
    NT2RI20023590 0 0 0 0 0 0 8.23 0 0 0 0 0 0
    NT2RI20041880 0 0 0 0 0 0 0 0 0 0 0 10.353 0
    NT2RI20046080 0 0 0 0 0 0 0 8.488 0 0 0 0 0
    NT2RI20216250 0 0 0 0 0 0 0 0 0 19.442 0 0 0
    NT2RI20252550 0 0 0 0 0 0 0 0 0 0 0 0 37.898
    NT2RP60000770 0 0 0 0 0 0 0 0 0 0 0 0 7.128
    NT2RP70045590 0 0 0 0 0 0 0 0 0 0 0 0 9.452
    NT2RP70063950 0 0 0 0 0 0 0 0 0 17.468 0 0 0
    NT2RP70195430 0 0 0 0 38.221 0 0 0 0 10.792 0 0 0
    NT2RP70198350 0 0 0 0 0 0 1.042 0 0 0 0 3.758 0
    NTONG20028070 0 0 0 0 0 0 0 0 0 0 0 0 13.079
    NTONG20046140 0 0 0 0 0 0 0 0 0 0 0 0 6.567
    NTONG20064840 0 0 0 3.068 0 0 0 0 0 0 0 0 0
    NTONG20067830 0 0 0 0 0 2.853 0 0 0 0 0 0 0
    NTONG20077560 0 0 0 4.791 0 0 0 0 0 0 0 0 0
    PANCR10000910 0 0 0 0.214 0 0 0 0 0 0 0 0 0
    PEBLM20024550 0 0 0 0 0 0 0 0 0 0 33.118 0 0
    PEBLM20052820 0 0 0 0 0 11.82 0 0 0 0 0 0 0
    PEBLM20074370 0 0 0 0 21.543 0 0 0 0 0 0 0 0
    PERIC20004780 0 0 0 7.727 0 0 0 0 0 0 0 0 0
    PLACE50000660 0 0 0 0 0 18.438 0 0 0 0 0 32.991 0
    PLACE60079250 0 0 0 0 0 0 0 23.248 0 0 0 0 0
    PLACE60136720 0 0 0 0 0 27.825 0 0 0 0 0 0 0
    PLACE60138830 0 0 0 0 0 0 0 0 0 0 0 0 38.39
    PROST20005670 0 0 0 0 0 14.432 0 0 0 0 0 0 0
    PROST20050670 0 0 0 11.45 0 0 0 0 0 0 0 0 17.889
    PROST20107820 0 0 0 0 0 0 0.243 0 0 0 0 0 0
    PROST20111050 0 0 0 25.26 0 0 0 0 0 0 0 0 0
    PROST20116600 0 0 0 16.676 0 0 0 0 0 0 0 0 0
  • TABLE 31
    PROST20120160 0 0 0 0 0 22.126 0 0 0 0 0 0 0
    PROST20123530 0 0 0 0 0 0 0 0 0 0 0 33.893 0
    PROST20161950 0 0 0 0 0 0 0 0 0 0 0 21.086 0
    PROST20171280 0 0 0 0 0 8.119 0 0 0 0 0 0 0
    PROST20175290 0 0 0 1.802 0 0 0 0 0 0 0 0 2.815
    PROST20185830 0 0 0 0 0 0 0 0 0 0 0 33.325 0
    PROST20191640 0 0 0 0 0 0 3.687 0 0 0 0 0 0
    PUAEN20015860 0 0 0 2.027 0 0 0 0 0 2.913 0 0 0
    PUAEN20030180 0 0 0 0 0 0 0 0 0 0 0 12.086 3.717
    PUAEN20044000 0 0 0 0 0 7.259 0 0 0 0 0 0 0
    PUAEN20078980 0 0 0 0 39.038 0 0 0 0 0 0 0 0
    PUAEN20085150 0 0 0 13.781 0 0 0 0 0 9.905 0 0 21.533
    PUAEN20108240 0 0 0 11.155 0 26.393 5.239 0 0 16.034 0 0 11.619
    SKMUS20012010 0 0 0 0 0 1.795 0 0 0 0 0 0 0
    SKNSH20062340 0 0 0 0 0 3.527 0 0 0 0 0 0 0
    SMINT20013480 0 0 0 0 0 0 0 0 32.864 0 0 0 0
    SMINT20042990 0 0 0 6.406 0 0 0 0 0 0 0 0 0
    SMINT20053300 0 0 0 0 0 0 0 0 0 0 51.332 0 0
    SMINT20076470 0 0 0 0 0 22.212 0 0 0 0 0 0 0
    SMINT20092330 0 0 0 16.746 0 0 0 0 0 0 0 0 0
    SMINT20101440 0 0 0 0 0 0 0 0 0 0 0 0 23.912
    SMINT20121220 0 0 0 0 0 0 0 0 12.384 0 0 0 3.877
    SMINT20121950 0 0 0 16.746 0 0 0 0 0 0 0 0 0
    SMINT20122910 0 0 0 6.546 0 0 0 0 0 0 0 0 0
    SMINT20130320 0 0 0 0 0 12.051 0 0 0 0 0 0 0
    SMINT20131810 0 0 0 0 0 22.212 0 0 0 0 0 0 0
    SMINT20144800 0 0 0 0 0 0 0 0 5.628 0 5.913 0 0
    SMINT20163960 0 0 0 0 0 0 0 0 50.098 0 0 0 0
    SPLEN20002220 0 0 0 0 0 0 12.214 0 0 0 0 0 0
    SPLEN20008740 0 0 0 0 1.761 0 0.487 0 0 0 0 0 0
    SPLEN20011410 0 0 0 0.67 0 0 0 0 0 0.963 0 0 2.094
    SPLEN20016260 0 0 0 0 0 0 0 0 0 0 0 67.455 0
    SPLEN20027440 0 0 0 0 0 0 2.23 0 7.901 0 0 0 0
    SPLEN20029310 0 0 0 0 0 0 4.078 0 0 0 0 0 0
    SPLEN20033960 0 0 0 0 0 0 0 0 0 0 0 67.455 0
    SPLEN20054290 0 0 0 5.201 0 0 0 0 0 3.738 0 0 4.063
    SPLEN20126190 0 0 0 0 0 0 36.501 0 0 0 0 0 0
  • TABLE 32
    SPLEN20128000 0 0 0 0 0 0 0 0.784 0 0 0 0 0.379
    SPLEN20145720 0 0 0 0 0 0 0 0 22.047 0 0 0 6.902
    SPLEN20146450 0 0 0 0 0 0 0 0 0 0 68.148 0 0
    SPLEN20147110 0 0 0 0 0 0 2.652 0 0 0 0 0 0
    SPLEN20149110 0 0 0 0.749 0 0 0 0 0 0 0 0 2.34
    SPLEN20157880 0 0 0 3.436 0 0 0 0 0 0 0 0 5.368
    SPLEN20158900 0 0 0 28.977 0 0 0 0 0 0 0 0 0
    SPLEN20171210 0 0 0 0 0 15.624 7.753 0 0 0 0 0 8.598
    SPLEN20179180 0 0 0 0 0 0 0 0 3.23 0 0 0 0
    SPLEN20186430 0 0 0 0 0 0 36.501 0 0 0 0 0 0
    SPLEN20204170 0 0 0 9.907 0 0 0 0 0 0 0 50.331 15.479
    SPLEN20212730 0 0 0 0 0 0 14.747 0 0 0 0 0 16.354
    SPLEN20214580 0 0 0 0 0 0 0 0 0 0 0 0 38.93
    SPLEN20250390 0 0 0 28.977 0 0 0 0 0 0 0 0 0
    STOMA20051200 0 0 0 0 0 0 0 0 0 0 0 0 14.012
    STOMA20062290 0 0 0 0 0 0 6.012 0 0 0 0 0 0
    STOMA20092890 0 0 0 4.072 0 0 5.737 0 0 0 0 0 0
    SYNOV20003970 0 0 0 0 0 0 0 0 0 48.614 0 0 0
    TESOP20005270 0 0 0 0 0 0 0 0 0 0 0 0 11.444
    TESTI10000940 0 0 0 0 0 0 0 22.629 0 0 0 0 0
    TESTI20001720 0 0 0 0 0 0 0 0 0 0 0 0 9.487
    TESTI20002720 0 0 0 6.872 0 0 0 0 0 0 0 0 0
    TESTI20004890 0 0 0 0 0 0 0 0 0 0 0 57.966 0
    TESTI20011200 0 0 0 0 0 0 0 0 0 0.986 0 0 0
    TESTI20035960 0 0 0 0 0 0 0 0 14.759 0 0 0 0
    TESTI20037560 0 0 0 0 0 0 0 0 0 0 0 0 11.634
    TESTI20044310 0 0 0 0 0 0 8.365 0 0 0 0 0 0
    TESTI20061110 0 0 0 14.633 0 0 0 47.3 0 0 0 0 0
    TESTI20063830 0 0 0 0 0 4.084 0 0 0 4.135 0 0 0
    TESTI20086210 0 0 0 0 0 0 0 0 35.791 0 0 0 0
    TESTI20152460 0 0 0 8.403 0 0 0 0 0 0 0 0 0
    TESTI20168960 0 0 0 0 0 0 0 0 0 43.832 0 0 0
    TESTI20170350 0 0 0 29.776 0 0 0 0 0 42.801 0 0 0
    TESTI20208400 0 0 0 11.599 0 0 0 0 0 0 0 0 0
    TESTI20213580 0 0 0 0 0 0 0 0 0 0 0 0 37.524
    TESTI20214250 0 0 0 1.222 0 0 1.722 0 0 0 0 0 1.909
    TESTI20254220 0 0 0 1.762 0 0 0 0 0 0 0 0 0
  • TABLE 33
    TESTI20258460 0 0 0 43.347 0 0 0 0 0 20.77 0 0 22.576
    TESTI20330310 0 0 0 0 0 0 0 0 0 0 0 0 34.12
    TESTI20334410 0 0 0 0 0 0 0 0 0 0 0 0 2.434
    TESTI20366910 0 0 0 0 0 0 0 0 0 0 0 84.653 0
    TESTI20391770 0 0 0 5.883 0 0 16.578 0 0 21.141 0 0 18.384
    TESTI20432750 0 0 0 0 31.972 0 0 0 0 0 0 0 0
    TESTI20455620 0 0 0 0 0 0 0 0 0 0 0 84.653 0
    THYMU20000570 0 0 0 0 0 0 0 0 0 0 0 0 1.504
    THYMU20058070 0 0 0 45.981 0 0 0 0 0 0 0 0 0
    THYMU20066100 0 0 0 0 0 0 0 0 0 0 0 0 30.115
    THYMU20075320 0 0 0 0 56.448 0 0 0 0 0 0 0 0
    ThYMU20081490 0 0 0 0 0 0 0 0 0 0 0 0 6.532
    THYMU20100410 0 0 0 0 0 18.787 0 0 0 19.023 0 0 0
    THYMU20101920 0 0 0 0 0 0 0 0 0 0 0 0 57.08
    THYMU20108310 0 0 0 0 0 0 54.53 0 0 0 0 0 0
    THYMU20119390 0 0 0 45.981 0 0 0 0 0 0 0 0 0
    THYMU20126900 0 0 0 0 0 3.915 0 0 0 0 0 0 0
    THYMU20128260 0 0 0 0 0 22.315 22.147 0 0 22.595 0 0 0
    THYMU20169680 0 0 0 0 0 0 0 0 0 7.541 0 0 0
    THYMU20193640 0 0 0 29.854 0 0 0 0 0 0 0 0 0
    THYMU20209590 0 0 0 7.868 0 0 11.085 25.432 0 0 0 0 12.293
    THYMU20235760 0 0 0 0 0 0 15.94 0 0 0 0 57.476 0
    THYMU20239430 0 0 0 0 0 0 54.53 0 0 0 0 0 0
    THYMU20240710 0 0 0 0 0 33.209 0 0 0 0 0 0 0
    THYMU20253250 0 0 0 0 0 13.123 0 29.879 46.138 0 0 0 0
    THYMU20286290 0 0 0 0 0 0 0 0 0 0 0 0 20.303
    TKIDN10000010 0 0 0 7.899 0 0 0 0 0 0 0 0 12.342
    TKIDN20005210 0 0 0 0 0 0 29.753 0 0 15.178 0 0 0
    TKIDN20030590 0 0 0 0 0 0 0 0 0 21.607 0 0 0
    TRACH20005020 0 0 0 0 0 0 47.167 0 0 0 0 0 0
    TRACH20005400 0 0 0 0 0 0 0 0 0 0 0 0 3.16
    TRACH20007020 0 0 0 5.573 0 0 0 0 0 0 0 0 0
    TRACH20019960 0 0 0 0 0 0 0 67.193 0 0 0 0 0
    TRACH20034840 0 0 0 38.787 0 0 0 0 0 0 0 0 0
    TRACH20079690 0 0 0 0 0 0 2.538 0 0 0 0 0 0
    TRACH20128110 0 0 0 5.533 28.17 0 0 17.886 0 0 0 0 34.582
    TRACH20149970 0 0 0 12.555 0 0 14.151 0 0 7.219 0 0 0
  • TABLE 34
    TRACH20183170 0 0 0 0 0 0 2.93 0 0 0 0 0 0
    UMVEN10001860 0 0 0 0 0 0 0 0.606 0 0 0 0 0
    UMVEN20003540 0 0 0 0 0 0 0 1.89 2.918 0 0 2.97 0.913
    UTERU20000740 0 0 0 37.308 0 0 0 0 0 0 0 0 0
    UTERU20030570 0 0 0 1.836 0 0 0 0 0 0 0 9.326 0
    UTERU20054460 0 0 0 0 75.184 0 0 0 0 0 0 0 0
    UTERU20055930 0 0 0 1.593 0 3.393 4.49 0 0 0 4.178 4.047 4.979
    UTERU20056010 0 0 0 0 0 0 0 5.848 0 2.601 0 0 0
    UTERU20064860 0 0 0 0 0 0 0 0 0 0 0 0 48.181
    UTERU20065930 0 0 0 1.048 0 5.951 2.953 0 0 1.506 0 0 3.275
    UTERU20070040 0 0 0 0 0 0 0 0 0 0 0 75.144 0
    UTERU20081300 0 0 0 0 0 0 0 0 0 46.104 0 0 0
    UTERU20084260 0 0 0 0 0 0 0 0 0 0 0 0 24.416
    UTERU20094350 0 0 0 0 0 5.388 26.737 0 0 16.367 0 0 5.93
    UTERU20120310 0 0 0 0 0 0 0 0 0 46.104 0 0 0
    UTERU20124070 0 0 0 0 0 24.8 0 0 0 0 0 0 0
    UTERU20164260 0 0 0 0 0 0 12.709 0 0 0 0 0 14.093
    UTERU20168220 0 0 0 0 0 4.05 10.05 0 0 6.152 0 0 0
    UTERU20183640 0 0 0 0 0 0 0 0 0 46.104 0 0 0
    ASTRO20032120 27.675 0 0 10.632 0 0 0 0 0 0 0 0 0
    ASTRO20125520 2.731 0 0 1.049 0 0 0 0 0 0 0 0 1.639
    BRACE20039040 4.789 0 0 3.68 9.367 0 0 0 0 0 0 9.348 0
    BRACE20060720 36.414 0 0 13.99 0 0 0 0 0 0 0 0 0
    BRACE20062640 15.593 0 0 5.99 0 0 0 0 29.9 0 0 0 9.36
    BRACE20090440 18.536 0 0 7.121 0 0 0 0 0 0 0 0 0
    BRACE20099570 72.245 0 0 27.755 0 0 0 0 0 0 0 0 0
    BRACE20111830 11.876 0 0 22.812 0 6.477 0 0 0 13.116 0 0 14.257
    BRACE20142570 22.91 0 0 44.008 0 0 12.401 0 0 0 0 0 0
    BRAWH20128270 16.614 0 0 0 0 9.061 8.993 0 31.859 0 33.472 0 0
    BRCAN20280360 4.46 0 0 0 8.724 4.865 0 5.539 0 2.463 0 0 0
    BRHIP20110800 64.423 0 0 0 0 0 0 0 0 35.577 0 0 0
    BRHIP20176420 47.719 0 0 0 0 13.013 12.915 0 0 26.353 0 0 0
    BRSSN20003120 19.877 0 0 7.636 0 21.682 10.759 0 0 0 40.045 0 0
    CTONG20105660 50.102 0 0 0 0 0 0 0 0 0 0 0 0
    CTONG20124010 15.543 0 0 0 0 4.239 0 0 0 0 0 0 0
    CTONG20133480 10.163 0 0 0 0 5.543 5.501 0 0 0 0 0 12.201
    CTONG20139070 7.966 0 0 4.591 0 2.172 2.156 0 0 0 0 0 2.391
  • TABLE 35
    CTONG20160560 3.674 0 0 0 0 0 3.977 0 0 0 0 0 0
    FCBBF10001210 18.354 0 0 0 0 10.01 0 0 35.196 0 0 0 0
    FCBBF10001550 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF10001710 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF10001820 15.666 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF10002430 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF10002700 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF10002800 10.435 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF10003220 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF10003740 73.865 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF10003760 78.7 0 0 0 0 0 21.3 0 0 0 0 0 0
    FCBBF10005060 34.365 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF10005460 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF10005500 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF20006780 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF20014270 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF20023700 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF20032970 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF20035280 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF20042170 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF20042560 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF20051220 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF20054280 72.245 0 0 27.755 0 0 0 0 0 0 0 0 0
    FCBBF20056370 5.134 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF20064520 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF20067810 11.69 0 0 0 0 6.376 0 0 0 0 0 0 7.017
    FCBBF20071860 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF20072650 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF20076330 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30008470 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30010810 9.702 0 0 1.864 9.488 2.646 0 0 0 0 0 0 5.824
    FCBBF30012350 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30012810 37.617 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30015940 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30019120 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30024750 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30028180 64.881 0 0 0 0 0 35.119 0 0 0 0 0 0
  • TABLE 36
    FCBBF30033050 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30039020 43.392 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30052180 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30054440 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30057290 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30062880 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30070770 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30071520 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30078290 20.784 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30083620 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30123470 4.055 0 0 0 0 0 0 0 7.775 0 8.169 0 2.434
    FCBBF30170590 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30172550 64.423 0 0 0 0 0 0 0 0 35.577 0 0 0
    FCBBF30175310 2.962 0 0 0 5.793 0 3.207 3.678 0 0 0 0 3.556
    FCBBF30178730 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30190850 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30195640 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30199610 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30215060 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30225660 64.881 0 0 0 0 0 35.119 0 0 0 0 0 0
    FCBBF30240960 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30242250 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30243640 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30247930 29.517 0 0 11.34 0 0 0 0 0 0 0 0 0
    FCBBF30252520 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30252800 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30252850 44.606 0 0 0 0 0 0 55.394 0 0 0 0 0
    FCBBF30262510 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30266780 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30266920 29.977 0 0 11.517 0 0 0 0 0 0 0 58.507 0
    FCBBF30278630 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30279030 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30281880 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30284720 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30285280 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF40001730 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF40005480 27.002 0 0 10.374 0 14.727 0 0 0 0 0 0 0
  • TABLE 17
    HCHON20007380 5.501 0 0 0 0 0 0 0 0 0 11.082 0 0
    HEART20072310 8.949 0 0 0 0 4.881 0 0 0 4.942 0 0 0
    HHDPC20068620 13.827 0 0 0 0 7.541 0 0 0 0 0 0 0
    HLUNG20023340 16.982 0 0 0 0 0 0 0 0 0 0 0 0
    KIDNE20017130 28.625 0 0 0 0 0 0 0 0 0 0 0 0
    KIDNE20028830 8.38 0 0 0 0 0 0 5.203 0 0 8.442 8.178 0
    MESAN20014500 5.328 0 0 6.141 0 0 0 0 0 0 0 0 0
    NT2RP70072690 43.392 0 0 0 0 0 0 0 0 0 0 0 0
    NT2RP70137640 20.975 0 0 0 0 0 0 0 0 11.583 0 0 0
    NTONG20067090 16.742 0 0 0 0 0 0 0 0 0 0 0 0
    PLACE60004630 14.415 0 0 0 0 0 0 17.901 0 0 0 0 0
    PROST20083600 3.325 0 0 2.555 0 0 1.8 0 0 1.836 0 0 3.992
    PROST20189770 24.007 0 0 0 0 0 0 0 0 0 0 0 14.411
    RECTM20003490 7.826 0 0 0 0 0 0 0 0 0 0 0 0
    SKNSH20008190 4.598 0 0 1.767 8.994 12.539 2.489 0 0 0 0 0 8.28
    SMINT20115880 34.363 0 0 0 0 0 0 0 0 0 0 0 0
    SPLEN20169720 3.746 0 0 2.878 0 0 0 0 0 2.069 0 0 0
    SPLEN20194050 2.646 0 0 1.016 0 7.215 1.432 6.571 5.073 1.461 0 0 1.588
    SPLEN20284240 51.503 0 0 0 0 0 0 0 0 0 0 0 0
    TESTI20083940 73.865 0 0 0 0 0 0 0 0 0 0 0 0
    TESTI20213150 37.439 0 0 0 0 0 0 0 0 0 0 0 0
    TESTI20254540 20.808 0 0 0 0 0 0 0 0 0 0 0 12.49
    TESTI20265250 16.076 0 0 3.088 0 0 0 0 0 0 16.193 0 0
    TRACH20118940 32.856 0 0 0 0 8.96 0 0 0 0 0 32.063 0
    UTERU20145480 60.769 0 0 0 0 0 0 0 0 0 0 0 0
    UTERU20146680 60.769 0 0 0 0 0 0 0 0 0 0 0 0
    ASTRO20155290 0 9.237 0 0 0 0 0 0 0 0 0 0 0
    BRAWH20030250 0 7.559 0 0 10.956 3.055 6.064 0 0 0 11.285 0 0
    BRAWH20113430 0 17.488 0 9.958 0 0 7.015 0 0 7.157 0 0 7.779
    BRAWH20122770 0 71.37 0 0 0 0 28.63 0 0 0 0 0 0
    BRHIP20005340 0 0.853 0 0 0 0 0.342 0 0 0.349 0 0 0
    BRHIP30001110 0 2.552 0 0.727 3.699 2.063 0 2.349 3.627 3.133 3.81 3.691 3.406
    BRSTN20002200 0 8.553 0 0 0 20.742 0 7.871 0 10.501 0 37.113 15.219
    CTONG20052900 0 57.236 0 0 0 0 0 0 0 0 0 0 0
    CTONG20108210 0 3.563 0 3.55 0 1.44 1.429 0 0 2.187 0 0 3.17
    DFNES20031920 0 7.467 0 0 0 3.018 0 0 0 0 0 0 0
    FEBRA10001900 0 19.812 0 0 0 0 0 18.233 0 0 0 0 0
  • TABLE 38
    FEBRA20003210 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20007620 0 15.507 0 0 0 0 0 0 0 0 0 22.43 0
    FEBRA20009090 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20010120 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20017050 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20018280 0 27.125 0 3.861 0 0 0 0 0 0 0 0 0
    FEBRA20025270 0 7.139 0 0 0 2.886 0 0 0 0 0 0 0
    FEBRA20025520 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20026110 0 54.171 0 0 0 0 21.73 0 0 0 0 0 24.098
    FEBRA20026280 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20029860 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20034680 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20037260 0 2.482 0 0.707 3.598 1.003 0 2.285 0 0 0 0 1.104
    FEBRA20040530 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20042190 0 70.959 0 0 0 0 0 0 0 29.041 0 0 0
    FEBRA20052910 0 9.04 0 0 0 0 0 0 0 0 0 13.076 0
    FEBRA20060610 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20072120 0 9.786 0 11.144 0 0 0 0 0 16.019 0 0 4.353
    FEBRA20079310 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20082010 0 5.978 0 0 0 0 2.398 0 0 0 0 0 2.659
    FEBRA20088360 0 79.225 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20090290 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20092890 0 34.98 0 0 50.703 0 0 0 0 14.316 0 0 0
    FEBRA20093520 0 70.959 0 0 0 0 0 0 0 29.041 0 0 0
    FEBRA20097310 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20113560 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20125070 0 18.603 0 0 26.964 0 0 0 0 0 0 0 0
    FEBRA20132740 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20140100 0 40.243 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20161120 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20166540 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20167390 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20171380 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20176800 0 23.704 0 0 0 9.581 0 21.815 0 9.701 0 0 0
    FEBRA20184330 0 77.838 0 22.162 0 0 0 0 0 0 0 0 0
    FEBRA20192420 0 20.225 0 5.758 0 0 0 0 0 8.277 0 0 0
    FEBRA20195820 0 100 0 0 0 0 0 0 0 0 0 0 0
  • TABLE 39
    FEBRA20196370 0 40.753 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20196630 0 21.712 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20197110 0 5.271 0 0 0 0 0 4.851 0 0 0 0 2.345
    FEBRA20211710 0 26.519 0 0 0 10.719 0 24.406 0 0 0 38.357 0
    FEBRA20214970 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20215500 0 77.838 0 22.162 0 0 0 0 0 0 0 0 0
    FEBRA20216360 0 50.44 0 14.361 0 0 0 0 0 0 0 0 0
    FEBRA20222040 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20223220 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20225040 0 4.094 0 0 0 0 0 3.768 11.636 0 0 0 0
    FEBRA20226010 0 77.838 0 22.162 0 0 0 0 0 0 0 0 0
    FEBRA20229560 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20229630 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20232850 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20235500 0 40.825 0 0 59.175 0 0 0 0 0 0 0 0
    HCHON20040020 0 1.957 0 0 0 1.582 0 0 0 0 0 0 1.741
    KIDNE20102650 0 5.89 0 0 0 0 2.363 0 0 0 0 0 0
    NT2RP70037240 0 23.02 0 26.217 0 0 0 0 0 0 0 0 0
    PEBLM20072960 0 4.311 0 0 0 0 0 0 0 0 0 0 0
    PLACE60169420 0 9.752 0 0 0 3.942 3.912 8.975 13.858 0 14.56 0 4.338
    SKMUS20003610 0 2.666 0 0 0 1.077 0 2.453 0 0 0 0 0
    SMINT20026890 0 2.93 0 10.012 0 1.184 4.702 0 0 0 0 0 1.304
    SMINT20033400 0 7.324 0 0 0 2.96 0 0 0 0 0 0 0
    SPLEN20020070 0 47.573 0 0 0 19.229 0 0 0 0 0 0 0
    SPLEN20079510 0 58.898 0 0 0 0 0 0 0 0 0 0 0
    TESTI20001000 0 48.295 0 0 0 39.041 0 0 0 0 0 0 0
    TESTI20094020 0 22.853 0 0 0 9.237 0 0 0 0 0 0 0
    THYMU20027560 0 18.25 0 0 0 0 0 0 0 0 0 0 0
    THYMU20180280 0 74.935 0 0 0 0 0 0 0 0 0 0 0
    THYMU20271250 0 0.446 0 2.287 2.587 0.902 0.179 0.411 0 0 0 4.518 0.198
    TRACH20003590 0 7.434 0 0 0 0 0 0 0 3.042 0 0 0
    UMVEN10001560 0 2.576 0 0 0 0 0 0 0 0 0 0 0
    UTERU20022940 0 13.576 0 0 0 0 1.815 0 0 0 0 0 4.026
    UTERU20046640 0 4.23 0 0 0 1.71 1.697 0 0 0 0 0 1.882
    UTERU20119060 0 17 0 0 0 13.742 13.639 0 0 0 0 0 0
    UTERU20144640 0 33.653 0 0 0 0 0 0 0 0 50.246 0 0
    UTERU20176130 0 51.268 0 0 0 0 0 0 0 0 0 0 0
  • TABLE 40
    ASTR020008010 0 0 1.267 0 0 0 0 0 0 0 0 0 0
    BRACE20276430 0 0 17.893 10.223 0 0 0 33.045 0 0 0 0 0
    BRAMY20103570 0 0 18.549 21.196 0 30.09 14.931 0 0 15.234 0 0 0
    BRAMY20120910 0 0 7.377 0 0 5.983 0 0 0 0 0 0 0
    BRAMY20162510 0 0 8.934 5.104 25.986 43.477 0 16.499 0 0 0 0 0
    BRAMY20196000 0 0 30.091 0 0 8.135 16.148 0 0 0 0 0 8.954
    BRAWH20164460 0 0 10.808 0 0 0 8.7 0 0 0 0 0 0
    BRCAN20273640 0 0 7.379 0 10.731 5.985 2.97 20.44 21.042 0 11.054 0 13.174
    BRCOC20105100 0 0 14.918 0 0 0 0 0 85.082 0 0 0 0
    BRHIP20198190 0 0 10.771 30.77 0 0 8.671 0 0 17.692 0 0 0
    BRHIP20222280 0 0 11.352 0 0 0 9.138 20.964 0 9.323 0 0 0
    BRHIP20254480 0 0 37.989 0 0 30.812 0 0 0 31.199 0 0 0
    BRHIP30004570 0 0 33.739 38.553 0 0 0 0 0 27.708 0 0 0
    CTONG20028410 0 0 26.318 15.036 0 0 21.185 0 0 10.807 0 0 0
    CTONG20091080 0 0 29.481 0 0 0 0 0 0 0 0 0 26.317
    CTONG20103480 0 0 2.2 7.541 0 1.784 3.542 4.063 0 1.807 6.591 0 3.927
    CTONG20126070 0 0 2.148 0 0 0 0 0 0 0 0 0 5.754
    CTONG20139340 0 0 8.617 24.615 0 0 6.936 0 0 7.077 0 0 7.692
    DFNES20001530 0 0 3.977 0 0 0 0 0 0 0 0 0 3.551
    HCHON20008150 0 0 3.469 0 0 2.814 2.793 0 0 0 10.394 0 0
    HHDPC20001040 0 0 4.596 1.313 0 0 0 0 0 0 0 0 2.052
    HLUNG20016330 0 0 9.947 0 0 0 0 0 0 0 0 0 0
    HLUNG20017120 0 0 4.096 0 35.74 0 0 0 0 0 0 0 0
    IMR3220002430 0 0 2.132 1.218 0 1.729 0 0 0 2.626 0 0 0.951
    KIDNE20007210 0 0 26.272 0 0 0 0 0 0 0 0 0 0
    KIDNE20021910 0 0 17.71 15.177 0 0 0 0 0 0 0 0 7.905
    KIDNE20124400 0 0 2.199 2.513 0 0 0 0 0 3.612 6.588 0 3.926
    MESAN10001260 0 0 2.218 7.605 0 0 1.786 0 0 3.644 0 0 1.98
    MESAN20029400 0 0 3.951 0 0 0 3.18 0 0 0 0 0 0
    MESAN20121130 0 0 7.329 0 0 0 0 0 0 6.019 0 0 6.543
    MESAN20153910 0 0 25.095 0 0 0 0 0 0 0 0 0 0
    NT2NE20159740 0 0 18.979 21.687 0 7.697 0 0 0 0 0 0 8.471
    NT2NE20177520 0 0 29.166 0 0 0 0 0 0 0 0 0 0
    NT2RI20086220 0 0 3.92 0 0 0 0 0 0 0 0 0 6.999
    NT2RI20250750 0 0 21.061 12.033 0 0 0 0 0 17.297 0 0 18.801
    NT2RP60000850 0 0 5.745 3.283 0 4.66 4.625 0 0 0 0 0 5.129
    NT2RP70044280 0 0 12.569 7.181 0 6.796 16.862 0 0 6.881 0 0 0
  • TABLE 41
    NT2RP70056750 0 0 7.226 8.256 0 5.861 11.633 0 0 8.901 0 0 3.225
    NT2RP70081610 0 0 15.599 4.456 0 0 0 0 0 6.405 0 0 0
    NTONG20009770 0 0 2.442 0 0 0 0 2.255 3.482 0 0 0 0
    OCBBF10000540 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF10001750 0 0 17.896 5.112 0 7.258 0 0 0 0 0 0 0
    OCBBF20006770 0 0 20.236 0 0 16.413 0 0 0 0 0 0 0
    OCBBF20013890 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20019830 0 0 8.974 0 0 0 0 0 0 0 0 0 0
    OCBBF20020150 0 0 17.182 9.817 0 0 0 0 0 0 0 0 15.338
    OCBBF20020830 0 0 27.302 0 0 0 0 25.211 0 0 0 0 0
    OCBBF20023570 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20028050 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20028650 0 0 65.522 0 0 0 0 0 0 0 0 0 0
    OCBBF20029800 0 0 54.907 0 0 0 0 0 0 45.093 0 0 0
    OCBBF20030280 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20030910 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20035930 0 0 55.403 0 0 0 44.597 0 0 0 0 0 0
    OCBBF20037440 0 0 52.585 0 0 0 0 0 0 0 0 0 0
    OCBBF20041680 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20045330 0 0 25.025 0 0 0 0 0 0 0 74.975 0 0
    OCBBF20046120 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20046470 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20046690 0 0 54.907 0 0 0 0 0 0 45.093 0 0 0
    OCBBF20048660 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20050770 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20051610 0 0 54.907 0 0 0 0 0 0 45.093 0 0 0
    OCBBF20053430 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20053490 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20053730 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20054200 0 0 78.844 0 0 0 21.156 0 0 0 0 0 0
    OCBBF20054760 0 0 5.808 0 0 4.71 0 0 0 0 0 0 0
    OCBBF20060300 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20062140 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20062410 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20066390 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20071210 0 0 52.585 0 0 0 0 0 0 0 0 0 0
    OCBBF20071840 0 0 100 0 0 0 0 0 0 0 0 0 0
  • TABLE 42
    OCBBF20072240 0 0 11.73 6.702 0 0 9.442 0 0 0 0 0 0
    OCBBF20073540 0 0 1.248 0.713 0 1.012 3.014 2.305 0 0 0 0 1.114
    OCBBF20074140 0 0 59.836 0 0 0 0 0 0 0 0 0 0
    OCBBF20076220 0 0 4.561 2.606 0 0 0 0 0 0 0 0 0
    OCBBF20079310 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20079460 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20081380 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20082830 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20085200 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20086400 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20086910 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20088140 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20088220 0 0 2.961 0 0 0 0 0 0 0 0 0 0
    OCBBF20091150 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20100400 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20103130 0 0 34.079 0 49.562 0 0 0 0 0 0 0 0
    OCBBF20104040 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20105570 0 0 22.763 13.005 0 0 0 0 0 0 0 0 0
    OCBBF20107090 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20107920 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20108580 0 0 33.1 4.728 0 0 13.322 0 0 20.388 0 0 0
    OCBBF20108630 0 0 55.216 0 0 44.784 0 0 0 0 0 0 0
    OCBBF20109310 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20111770 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20116850 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20118970 0 0 21.447 0 0 17.395 0 0 61.158 0 0 0 0
    OCBBF20120390 0 0 9.527 3.266 0 7.727 26.074 0 0 31.296 0 0 22.111
    OCBBF20121390 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20122620 0 0 36.036 0 0 0 29.008 0 0 0 0 0 0
    OCBBF20124360 0 0 59.836 0 0 0 0 0 0 0 0 0 0
    OCBBF20127040 0 0 25.938 14.819 0 0 0 0 0 21.301 0 0 0
    OCBBF20127140 0 0 7.211 4.12 0 0 0 0 0 0 0 0 0
    OCBBF20127550 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20128120 0 0 25.584 0 74.416 0 0 0 0 0 0 0 0
    OCBBF20129360 0 0 55.403 0 0 0 44.597 0 0 0 0 0 0
    OCBBF20130910 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20132850 0 0 63.64 36.36 0 0 0 0 0 0 0 0 0
  • TABLE 43
    OCBBF20140890 0 0 24.517 0 0 19.885 19.735 0 0 0 0 0 0
    OCBBF20145760 0 0 4.539 2.593 0 0 0 0 0 3.728 0 0 4.052
    OCBBF20148280 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20151150 0 0 44.332 12.664 0 0 0 0 0 0 0 0 0
    OCBBF20153340 0 0 65.522 0 0 0 0 0 0 0 0 0 0
    OCBBF20153350 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20155060 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20164670 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20170690 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20173060 0 0 55.403 0 0 0 44.597 0 0 0 0 0 0
    OCBBF20173250 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20178150 0 0 65.522 0 0 0 0 0 0 0 0 0 0
    OCBBF20180840 0 0 16.434 9.389 0 4.443 4.41 0 0 0 0 0 0
    OCBBF20186870 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20189560 0 0 2.102 3.604 0 1.705 0 0 0 0 0 0 1.877
    PEBLM20044520 0 0 5.03 1.916 0 2.72 10.797 0 0 12.393 0 0 5.987
    PEBLM20071880 0 0 10.845 0 0 0 0 0 0 0 0 0 0
    PLACE60060420 0 0 6.763 0 0 0 0 0 0 0 0 0 0
    PROST20047390 0 0 27.713 10.556 0 0 0 0 0 7.587 0 0 0
    PUAEN20003740 0 0 1.59 0.909 1.156 0.322 2.24 0 0 0.653 0 0 1.775
    SMINT20029760 0 0 6.48 0 0 0 10.432 0 0 5.322 0 0 0
    SPLEN20008820 0 0 2.182 0 0 0 0 0 0 0 0 0 1.948
    SPLEN20084600 0 0 1.627 0 0 0 0 0 0 2.673 0 0 0
    SPLEN20095550 0 0 10.552 0 0 0 0 0 0 0 0 0 9.419
    SPLEN20099700 0 0 12.671 0 0 0 0 0 0 5.203 0 0 0
    SPLEN20140800 0 0 11.772 3.363 0 0 0 0 0 0 0 0 0
    SPLEN20173510 0 0 7.473 2.135 0 0 9.023 0 9 0 11.195 0 6.671
    SPLEN20211220 0 0 20.261 0 0 0 0 0 0 33.279 0 0 18.087
    SPLEN20250170 0 0 41.66 0 0 0 0 0 0 0 0 0 0
    STOMA20067800 0 0 10.791 0 0 0 0 0 0 0 0 0 0
    TESTI20031270 0 0 13.265 0 0 10.759 0 0 0 0 0 0 0
    TESTI20116830 0 0 40.221 0 0 0 0 0 0 0 0 0 0
    TESTI20121550 0 0 7.961 0 0 0 6.408 0 0 6.538 0 0 7.106
    TESTI20234140 0 0 5.057 2.889 0 0 0 0 0 0 0 0 0
    TESTI20442760 0 0 11.782 0 0 0 0 10.879 0 0 0 0 10.517
    THYMU20039810 0 0 0.649 0 0 0 0.522 0 1.85 2.664 0 0 0.579
    THYMU20070360 0 0 19.184 0 0 7.78 0 0 0 0 0 0 8.562
  • TABLE 44
    TRACH20033230 0 0 4.422 0 0 7.173 7.119 0 0 9.079 0 0 3.947
    TRACH20084720 0 0 3.898 1.114 0 0 0 0 5.558 0 0 0 8.7
    BRACE20067430 0 22.168 11.047 15.779 0 4.48 8.892 0 0 4.536 33.098 0 0
    BRAWH10000930 0 1.15 2.292 0.655 0 0 0.461 0 0 0 1.717 0 0.511
    BRHIP20003120 0 16.166 8.056 9.205 0 6.534 32.424 0 0 13.232 0 0 14.383
    BRSSN20152380 0 8.534 8.505 4.859 0 0 10.27 0 0 6.985 12.742 0 0
    FEBRA20024100 0 66.741 33.259 0 0 0 0 0 0 0 0 0 0
    FEBRA20027810 0 17.057 25.5 43.707 0 6.894 6.842 0 0 0 0 0 0
    FEBRA20037500 0 9.102 2.268 2.591 0 1.839 0 0 12.934 1.862 0 0 6.073
    FEBRA20082100 0 16.72 8.332 4.761 0 6.758 0 0 23.761 0 0 0 0
    FEBRA20098460 0 51.462 25.645 0 0 0 0 0 0 0 0 0 22.893
    FEBRA20144170 0 4.038 2.012 0.766 0 3.264 7.559 6.194 3.826 3.856 4.019 5.841 1.198
    FEBRA20145780 0 0 27.189 0 0 0 0 0 0 0 0 0 0
    FEBRA20233770 0 19.338 9.637 0 28.03 0 15.515 0 27.481 0 0 0 0
    HHDPC10000830 0 2.44 2.432 1.389 0 1.972 0 2.246 0 0 3.643 0 2.171
    MESAN20025190 0 11.561 5.761 0 0 4.673 0 0 0 4.732 0 0 5.143
    MESAN20089360 0 9.917 4.942 5.647 0 12.025 3.978 0 0 4.059 0 0 0
    NT2RI20048840 0 11.556 0.96 0 0 0 0 0 0 0.788 2.876 0 0
    NT2RP70043480 0 5.634 16.844 0 0 0 0 0 8.006 0 0 0 0
    OCBBF20032460 0 24.396 24.315 0 0 9.861 9.786 0 0 19.969 0 0 0
    OCBBF20039250 0 2.077 1.035 0 3.011 1.679 0 0 0 0 0 3.004 0
    OCBBF20049300 0 25.873 12.893 0 0 0 0 23.811 0 0 0 37.423 0
    OCBBF20061720 0 13.071 13.027 0 0 5.283 0 12.029 18.574 0 19.515 0 0
    OCBBF20078920 0 21.239 5.292 0 0 0 0 0 0 0 0 15.36 0
    OCBBF20084660 0 42.651 10.627 0 0 0 0 0 0 0 31.84 0 0
    OCBBF20087010 0 27.016 40.389 0 0 10.92 21.675 0 0 0 0 0 0
    PROST20087700 0 1.945 2.907 7.197 0 3.93 4.68 0 0 6.367 2.903 2.813 3.46
    PROST20153320 0 6.425 3.202 27.441 0 2.597 10.31 0 18.262 5.259 0 0 0
    TRACH20135520 0 25.898 12.906 7.374 0 0 10.389 0 0 31.797 0 0 0
    ADIPS20004250 1.434 0 0.964 0 0 0 1.553 0 0 1.584 0 0 0
    ASTRO10001650 4.095 0 11.014 0 0 0 0 0 0 0 0 0 0
    BRACE20056810 3.689 0 4.961 14.879 0 13.076 16.971 4.581 0 20.37 7.431 7.199 3.321
    BRACE20059370 22.318 0 7.504 8.574 0 0 0 0 0 0 0 0 0
    BRACE20106690 11.777 0 31.677 9.049 0 0 19.124 0 0 6.504 0 0 7.069
    BRACE20210140 10.945 0 14.719 4.205 0 0 17.772 0 0 18.132 0 0 0
    BRAWH20103290 13.868 0 6.217 21.311 0 10.085 20.017 0 0 15.317 0 0 11.099
    BRAWH20121640 38.493 0 25.884 14.788 0 0 20.835 0 0 0 0 0 0
  • TABLE 45
    BRHIP20005530 4.747 0 12.769 1.824 0 2.589 2.57 0 0 5.243 0 0 2.85
    BRHIP20217620 5.147 0 3.461 7.91 0 0 8.358 0 0 11.369 0 0 3.09
    BRHIP20218580 6.182 0 8.314 4.75 0 3.372 3.346 0 0 3.414 0 0 0
    BRHIP20238880 0.68 0 3.2 2.089 0 1.854 2.208 1.688 1.303 0.751 1.369 2.653 4.488
    CTONG20075860 11.104 0 14.933 0 0 0 0 0 21.292 0 0 0 0
    CTONG20129960 5.394 0 7.255 0 0 0 2.92 0 0 0 0 0 6.476
    FCBBF10000240 8.112 0 10.91 0 0 6.637 6.587 0 0 6.72 0 7.916 0
    FCBBF10000630 11.049 0 7.43 0 0 6.026 11.962 0 0 6.102 0 0 0
    FCBBF10001150 37.553 0 25.252 14.427 0 0 0 0 0 0 0 0 0
    FCBBF10004120 3.575 0 7.212 0 0 0 5.806 0 0 0 0 0 2.146
    FCBBF10005740 7.67 0 15.473 2.947 0 10.458 8.303 0 7.354 6.353 0 0 4.604
    FCBBF20075560 16.883 0 11.353 0 0 0 0 0 0 0 0 0 0
    FCBBF30018550 31.042 0 3.479 1.988 0 0 0 0 0 0 0 0 0
    FCBBF30025560 59.793 0 40.207 0 0 0 0 0 0 0 0 0 0
    FCBBF30086440 15.918 0 10.704 0 0 0 8.616 0 0 0 0 0 0
    FCBBF30090690 8.273 0 5.563 6.357 0 22.561 17.913 0 0 4.569 0 0 34.763
    FCBBF30189490 52.288 0 17.58 0 0 0 0 0 0 14.438 0 0 15.693
    FCBBF30233680 4.533 0 6.096 0 0 0 7.361 0 0 2.503 0 0 2.721
    FCBBF30240020 10.485 0 28.201 16.112 0 5.718 5.675 0 0 0 0 0 0
    HCHON20007510 6.596 0 4.435 0 0 0 3.57 0 0 0 0 0 3.959
    HCHON20016650 2.851 0 5.751 2.191 0 9.329 0 0 0 6.297 0 0 0
    HHDPC20095280 12.007 0 8.074 4.613 0 0 0 0 0 6.631 0 0 14.415
    KIDNE20002520 1.579 0 6.37 1.213 0 3.444 6.837 0 6.055 3.488 0 3.082 2.843
    KIDNE20009470 9.338 0 9.419 0 9.132 0 2.527 0 0 0 0 0 2.803
    NT2RI20003480 16.371 0 44.033 0 0 0 0 0 0 0 0 0 0
    NT2RI20055790 17.338 0 11.659 0 0 0 0 0 0 19.149 0 0 0
    NT2RP70027380 10.635 0 35.756 4.086 0 0 5.756 0 0 5.873 0 0 6.384
    NT2RP70032610 2.51 0 3.376 0 0 0 0 0 0 0 0 0 0
    NT2RP70062230 7.806 0 10.498 17.994 0 0 4.225 0 0 8.622 15.726 0 0
    OCBBF10001850 15.555 0 31.379 0 0 0 4.21 0 0 0 0 0 0
    OCBBF20022900 18.632 0 12.529 0 0 20.324 0 0 0 0 0 0 11.184
    OCBBF20026630 59.793 0 40.207 0 0 0 0 0 0 0 0 0 0
    OCBBF20049840 44.001 0 29.587 0 0 0 0 0 0 0 0 0 26.412
    OCBBF20059560 5.245 0 3.527 6.045 10.258 5.721 0 6.513 0 0 10.566 0 3.148
    OCBBF20068490 3.734 0 7.532 0 0 0 0 0 0 0 0 0 0
    OCBBF20071960 33.142 0 66.858 0 0 0 0 0 0 0 0 0 0
    OCBBF20080410 7.723 0 2.597 0 0 0 4.18 0 0 0 0 0 0
  • TABLE 46
    OCBBF20094240 13.407 0 9.015 0 0 0 0 0 0 0 0 0 0
    OCBBF20097720 4.351 0 5.851 6.686 0 7.119 9.42 2.702 4.172 12.014 0 4.246 1.306
    OCBBF20108190 23.173 0 15.583 8.903 0 0 0 0 0 0 0 0 13.91
    OCBBF20108430 27.517 0 18.503 0 0 0 0 0 0 0 0 0 0
    OCBBF20126780 25.486 0 25.707 29.374 0 0 6.898 0 0 0 0 0 0
    OCBBF20130110 13.949 0 9.38 0 0 22.823 0 0 0 7.703 0 0 0
    OCBBF20139260 22.924 0 77.076 0 0 0 0 0 0 0 0 0 0
    OCBBF20148730 26.202 0 17.619 0 0 0 28.366 0 0 0 0 0 0
    OCBBF20149280 59.793 0 40.207 0 0 0 0 0 0 0 0 0 0
    OCBBF20164050 71.253 0 28.747 0 0 0 0 0 0 0 0 0 0
    OCBBF20173980 2.376 0 9.588 1.826 0 3.888 9.005 0 4.557 6.562 4.788 0 4.28
    OCBBF20178880 31.476 0 21.165 0 0 0 17.037 0 0 0 0 0 0
    OCBBF20180120 5.185 0 3.487 0 0 2.828 0 0 0 0 0 0 0
    OCBBF20188730 5.12 0 5.164 0 0 0 1.386 0 0 2.828 0 0 4.61
    PROST20057930 7.245 0 4.872 0 0 0 0 0 0 0 0 0 4.349
    SPLEN20162680 3.991 0 2.147 0.307 0 0.435 0 0 0 0 0 1.558 0.479
    SPLEN20211940 12.464 0 4.191 0 0 0 3.373 0 0 0 0 0 0
    TESTI20184620 5.221 0 7.021 0 0 5.695 2.826 0 0 0 0 0 9.401
    TESTI20211240 10.559 0 7.1 0 0 5.759 17.146 0 0 11.662 0 0 0
    TESTI20369690 19.913 0 8.927 2.55 0 0 7.186 0 0 3.666 0 0 3.984
    THYMU20141670 10.152 0 20.48 0 0 0 0 0 0 0 0 19.814 6.094
    TRACH20028030 7.7 0 2.589 2.958 0 4.199 0 0 0 0 23.268 7.514 0
    UTERU20099720 13.09 0 39.61 0 0 0 3.543 0 0 3.614 0 0 0
    UTERU20135860 24.344 0 8.185 0 0 0 0 0 23.341 13.444 0 0 0
    BRACE20057190 5.487 14.807 0 6.324 32.194 5.985 0 6.814 0 3.03 11.054 0 0
    BRHIP20191860 7.292 9.84 0 0 0 3.977 0 0 0 4.027 0 0 0
    BRHIP20214950 11.849 15.989 0 4.552 46.351 0 0 14.715 0 6.544 0 0 0
    FCBBF10003670 5.613 3.787 0 0 0 1.531 0 0 0 1.55 0 0 0
    FCBBF10004370 23.626 31.88 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30013770 19.023 25.669 0 0 0 0 10.297 0 0 0 0 0 0
    FCBBF30095260 21.826 29.451 0 0 0 23.808 11.814 0 0 0 0 0 13.101
    FCBBF30246230 41.402 13.966 0 0 0 0 0 0 0 0 0 0 12.426
    FEBRA20002100 1.306 3.524 0 0 0 0 0.707 0 0 0.721 0 0 0
    FEBRA20034360 10.27 13.858 0 0 0 5.601 0 0 39.387 0 0 0 0
    FEBRA20095140 12.239 24.772 0 0 0 3.338 0 0 0 3.379 0 0 0
    FEBRA20130190 42.565 57.435 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20204060 42.565 57.435 0 0 0 0 0 0 0 0 0 0 0
  • TABLE 47
    HCHON20008320 6.536 8.819 0 0 0 0 0 0 0 0 0 0 0
    LIVER20028420 3.527 9.518 0 0 0 1.924 0 4.38 0 0 0 0 6.351
    TRACH20111130 8.722 23.539 0 3.351 0 0 0 0 0 4.817 0 0 5.236
    ASTRO20108190 6.215 3.355 6.687 6.686 0 3.39 4.037 0 2.384 4.119 0 0 0
    BRACE20003070 6.528 2.936 10.243 20.064 0 0 1.178 2.702 0 2.403 0 0 1.306
    BRACE20060550 7.391 4.987 2.485 4.259 0 2.016 4.001 0 0 0 0 0 2.218
    BRAWH20004600 2.255 1.521 1.516 9.097 0 1.23 1.831 1.4 2.162 1.245 4.543 0 4.061
    BRAWH20011710 3.423 4.619 15.345 9.644 0 9.334 6.176 1.417 0 1.89 2.299 0 4.794
    BRAWH20016620 8.494 34.385 5.712 3.263 0 0 4.598 0 16.288 0 0 0 5.099
    BRHIP10001740 9.366 25.278 6.298 3.598 0 5.108 0 0 17.961 5.173 0 18.281 5.622
    BRSTN10000830 4.718 1.592 4.759 1.36 0 1.93 0.638 0 2.262 1.303 0 2.302 0
    CTONG10000940 10.792 16.505 4.354 1.106 1.407 2.747 0 1.787 4.139 2.781 1.45 0 0.864
    CTONG20150910 3.001 2.024 2.018 0.576 0 0 0 0 0 0 0 0 1.801
    D3OST10002670 7.978 10.765 5.365 0 0 0 0 9.907 0 0 0 15.57 0
    FCBBF10000380 20.755 28.007 41.87 0 0 0 0 0 0 0 0 0 0
    FCBBF10000770 19.451 22.208 13.079 0 0 0.816 0 0 0 0 0 0 0.898
    FCBBF10003770 39.957 26.958 13.434 0 0 0 0 0 0 0 0 0 0
    FCBBF20059090 11.53 15.558 31.013 4.43 0 0 6.241 0 0 19.102 0 0 6.921
    FCBBF30016320 2.852 3.848 13.424 1.096 0 0 0 3.542 0 0 0 0 0
    FCBBF30016570 8.716 11.762 11.722 11.72 0 4.754 11.795 0 0 9.627 8.78 0 5.232
    FCBBF30049550 28.476 19.212 28.723 0 0 0 0 0 0 23.589 0 0 0
    FCBBF30083820 19.899 26.851 13.381 0 0 0 0 0 0 0 0 0 0
    FCBBF30238870 17.508 23.625 58.866 0 0 0 0 0 0 0 0 0 0
    FCBBF40001420 13.508 18.228 18.167 18.164 0 11.051 3.656 0 0 0 0 0 4.054
    FEBRA10001880 38.663 15.651 36.398 0 0 2.109 0 0 0 2.135 0 0 0
    FEBRA20004620 5.215 7.037 7.013 28.049 0 0 31.051 0 0 8.64 0 0 6.261
    FEBRA20080810 1.308 3.531 4.399 1.508 0 2.141 2.124 3.249 0 0.722 2.636 0 0
    FEBRA20086620 5.865 11.87 1.972 5.633 0 6.397 11.11 0 0 3.239 0 11.446 1.76
    FEBRA20095880 8.952 24.158 42.136 0 0 0 19.382 0 0 0 0 0 5.373
    HHDPC20034390 2.819 1.268 5.371 1.625 0 0.513 1.78 0 0 1.816 0.947 0 0.846
    HLUNG10000550 1 1.349 4.035 0 0 0 0 0 1.918 1.105 4.029 1.952 1.201
    NT2RI20023160 1.481 1.999 0.996 0.569 0 0 0 0 2.84 0.818 0 0 0.889
    NT2RI20023910 4.495 4.043 1.007 0 0 4.086 0 1.86 0 0 0 0 1.799
    NT2RI20025400 3.194 17.238 2.148 1.227 0 6.967 6.915 7.932 0 5.291 6.434 24.933 1.917
    NT2RI20028470 6.957 9.388 7.797 0 0 1.265 0 0 0 1.281 0 0 2.784
    NT2RI20054050 0.519 1.4 0.349 0.199 0 0 0.561 0 0 0.573 3.134 0 1.245
    NT2RI20076290 3.724 5.025 5.008 1.431 0 4.062 0 0 0 0 0 0 0
  • TABLE 48
    NT2RI20091730 2.061 5.561 1.386 0 0 1.124 0 0 0 1.138 0 0 1.237
    NT2RI20091940 1.816 9.799 9.767 0 0 0.99 1.965 0 0 1.003 0 0 0
    NT2RP70036880 2.728 1.841 8.256 4.193 0 6.696 3.692 0 0 0 0 0 4.913
    NT2RP70078420 3.543 4.781 2.383 4.084 6.93 0 0 0 0 1.957 7.139 0 2.127
    OCBBF20047570 18.314 30.89 12.315 3.518 8.955 2.497 0 5.686 0 0 0 0 0
    OCBBF20080050 11.733 7.916 21.697 6.762 0 6.399 0 0 0 1.62 0 0 0
    OCBBF20125530 4.333 11.695 4.371 0 4.238 1.182 0 2.691 0 2.393 4.365 4.229 0
    OCBBF20140640 2.523 10.215 3.394 0 0 1.376 0 0 0 4.18 10.167 4.925 0
    TRACH20032720 6.845 9.236 9.205 2.63 0 11.2 3.705 8.5 13.125 3.78 0 0 4.109
    TRACH20141240 3.814 5.146 2.565 1.465 0 4.16 2.064 0 3.657 0 0 0 3.434
    UTERU20004240 3.138 4.234 1.055 3.014 3.069 0.856 1.699 3.897 3.009 0 0 3.062 0
  • TABLE 49
    CloneID FEHRT HEART
    FEHRT20003250 100 0
    OCBBF20189560 35.243 0
    BRAWH20029630 0 79.6
    CTONG20150910 0 5.418
    HCHON20007510 0 23.818
    HEART20003060 0 90.384
    HEART20005410 0 53.555
    HEART20021840 0 100
    HEART20025980 0 100
    HEART20034320 0 100
    HEART20037810 0 100
    HEART20049400 0 100
    HEART20049410 0 63.375
    HEART20049800 0 100
    HEART20061950 0 63.227
    HEART20063340 0 100
    HEART20067870 0 100
    HEART20067890 0 100
    HEART20072310 0 32.316
    HEART20074430 0 100
    HEART20077670 0 100
    HEART20089940 0 100
    HEART20090000 0 68.952
    HEART20095990 0 100
    HLUNG10000550 0 3.611
    HLUNG20017120 0 21.996
    KIDNE20028390 0 48.974
    KIDNE20028830 0 15.131
    NTONG20029480 0 44.44
    OCBBF10001750 0 48.053
    PROST20127800 0 48.531
    SKMUS20001980 0 21.074
    SKMUS20003610 0 7.134
    SMINT20026890 0 7.842
    SMINT20121220 0 23.322
    SMINT20122910 0 30.763
    SMINT20183530 0 65.405
    SPLEN20008740 0 3.252
    SPLEN20027440 0 14.879
    SPLEN20162680 0 2.882
    STOMA20062290 0 40.108
    TESTI20254220 0 16.559
    THYMU20271250 0 3.582
    TRACH20141240 0 6.886
    UTERU20004240 0 5.666
  • TABLE 50
    CloneID FEKID KIDNE
    ASTRO10001650 0 7.727
    ASTRO20108190 0 2.346
    BGGI120006160 0 3.117
    BRACE20039040 0 9.038
    BRACE20060550 0 6.974
    BRAMY20102080 0 63.37
    BRAWH20004600 0 2.128
    BRAWH20125380 0 35.37
    BRAWH20162690 0 4.596
    BRHIP20115760 0 66.835
    BRHIP20205090 0 65.282
    BRHIP20238880 0 1.283
    CTONG20052650 0 65.178
    CTONG20108210 0 2.491
    CTONG20128470 0 6.004
    CTONG20133480 0 19.179
    CTONG20139070 0 7.516
    D9OST20000310 0 16.47
    DFNES20001530 0 11.162
    FCBBF10001820 0 59.128
    FEBRA20002100 0 4.929
    HCHON20008980 0 35.524
    HCHON20016650 0 5.38
    HLUNG20033780 0 32.277
    KIDNE20002520 0 2.979
    KIDNE20003940 0 100
    KIDNE20006780 0 100
    KIDNE20007210 0 73.728
    KIDNE20007770 0 19.958
    KIDNE20008010 0 100
    KIDNE20009470 0 8.811
    KIDNE20011170 0 77.71
    KIDNE20011400 0 100
    KIDNE20013730 0 24.839
    KIDNE20017130 0 54.019
    KIDNE20018730 0 100
    KIDNE20018970 0 100
    KIDNE20020150 0 100
    KIDNE20021680 0 100
    KIDNE20021910 0 24.85
    KIDNE20021980 0 100
    KIDNE20022620 0 100
    KIDNE20024830 0 100
    KIDNE20027250 0 35.87
    KIDNE20027950 0 100
    KIDNE20028390 0 25.593
    KIDNE20028830 0 7.907
    KIDNE20029800 0 10.988
    KIDNE20067330 0 100
    KIDNE20079440 0 35.045
    KIDNE20096280 0 100
    KIDNE20096470 0 100
    KIDNE20100070 0 100
    KIDNE20100840 0 100
    KIDNE20101370 0 100
    KIDNE20101510 0 100
    KIDNE20102650 0 8.237
    KIDNE20102710 0 100
    KIDNE20104300 0 33.246
    KIDNE20106740 0 100
    KIDNE20107390 0 100
    KIDNE20107500 0 74.264
    KIDNE20107620 0 100
    KIDNE20109730 0 100
    KIDNE20109890 0 100
    KIDNE20112000 0 100
    KIDNE20115080 0 65.178
    KIDNE20118580 0 100
    KIDNE20120090 0 33.186
    KIDNE20121880 0 62.256
    KIDNE20122910 0 83.085
    KIDNE20124400 0 6.171
    KIDNE20125630 0 100
    KIDNE20126010 0 100
    KIDNE20126130 0 100
    KIDNE20127100 0 33.012
    KIDNE20127450 0 100
    KIDNE20127750 0 100
    KIDNE20130450 0 100
    KIDNE20131580 0 63.24
    KIDNE20132180 0 100
    KIDNE20137340 0 100
    KIDNE20138010 0 100
    KIDNE20141190 0 49.697
    KIDNE20144890 0 100
    KIDNE20148900 0 100
    KIDNE20163880 0 100
    KIDNE20180710 0 49.105
    KIDNE20181660 0 100
    KIDNE20182690 0 100
    KIDNE20186780 0 100
    KIDNE20190740 0 100
    LIVER20035110 0 28.683
    MESAN20025190 0 16.169
    NOVAR20000380 0 2.166
    NT2RI20054050 0 2.936
    NT2RP70043480 0 7.879
    PROST20107820 0 1.696
    PROST20123530 0 32.771
    PROST20161950 0 20.387
    PUAEN20030180 0 46.744
    SKMUS20003610 0 3.728
    SMINT20033400 0 10.243
    TBAES20000590 0 5.253
    TESTI20044310 0 29.162
    TESTI20082330 0 45.847
    TRACH20032720 0 12.917
    UTERU20099720 0 12.351
    BRACE20003070 25.479 0
    BRCOC20031870 34.023 0
    CTONG20125640 85.462 0
    FCBBF30016320 33.393 0
    HCHON20002260 8.723 0
    HLUNG10000550 11.709 0
    PROST20130530 64.069 0
    SPLEN20169720 43.864 0
    SPLEN20194050 30.978 0
    KIDNE20028720 12.368 1.993
  • TABLE 51
    CloneID FELNG HLUNG
    BRACE20096200 0 70.38
    BRAWH20004600 0 2.238
    BRAWH20030250 0 11.121
    BRCAN20006390 0 61.519
    BRCAN20280360 0 8.855
    BRHIP20238880 0 1.35
    CTONG10000940 0 1.428
    CTONG20103480 0 6.495
    CTONG20129960 0 10.709
    CTONG20155180 0 48.707
    FCBBF10001210 0 36.439
    FEBRA20144170 0 1.98
    FEBRA20197110 0 7.756
    HHDPC20034390 0 0.933
    HLUNG20016330 0 29.367
    HLUNG20016770 0 12.888
    HLUNG20017120 0 12.093
    HLUNG20023340 0 33.714
    HLUNG20033780 0 33.957
    HLUNG20084390 0 100
    IMR3220002430 0 3.147
    LIVER20028420 0 14.004
    NOVAR20000380 0 2.278
    NT2RI20054050 0 2.059
    NT2RI20091730 0 4.091
    NT2RP70044280 0 12.369
    OCBBF20020830 0 40.304
    OCBBF20125530 0 4.302
    PLACE60004630 0 28.618
    PROST20057930 0 14.383
    PROST20107820 0 0.892
    PROST20185830 0 33.898
    PUAEN20030180 0 12.294
    SMINT20121220 0 12.822
    SPLEN20002220 0 44.799
    SPLEN20054290 0 26.875
    SPLEN20128000 0 1.253
    SPLEN20157300 0 51.319
    SPLEN20176200 0 18.8
    SPLEN20179180 0 3.344
    SPLEN20211940 0 12.373
    STOMA20013890 0 21.183
    TBAES20000590 0 5.527
    TESTI20094230 0 59.311
    TESTI20184620 0 10.365
    TESTI20334410 0 8.049
    THYMU20000570 0 4.974
    THYMU20039810 0 1.915
    TRACH20007020 0 14.4
    TRACH20141240 0 3.786
    TRACH20183170 0 10.745
    D9OST20033970 61.464 0
    FELNG20002410 100 0
    HCHON20016650 33.188 0
    KIDNE20029800 67.783 0
    OCBBF20145760 78.585 0
    SPLEN20162680 9.292 0
    TESTI20214250 37.027 0
    TRACH20005400 30.64 0
    HCHON20002260 8.672 2.958
    HLUNG10000550 11.642 3.971
    NT2RI20023910 34.882 8.923
    SPLEN20008740 10.483 1.788
  • TABLE 52
    Alteration of the expression level of each clone due to
    TNF-α stimulation to human monocyte cell line THP-1 and
    alteration of the expression level of each clone due to co-
    culture of gastric cancer cell line MKN45 with Helicobacter
    pylori. ctl, TNF_1 h, and TNF_3 h
    in the column of THP-1, respectively,
    indicate the relative mRNA expression levels in
    unstimulated THP-1, in the cell stimulated with 10 ng/mL TNF-α
    for 1 hour, and in the cell stimulated with 10 ng/mL TNF-α for 3
    hours; ctl, Hp, and ΔcagE in the column of MKN45 indicate the
    relative mRNA expression levels in MKN45 cultured without
    Helicobacter pylori, in the cells co-cultured with cag PAI-
    positive Helicobacter pylori (TN2)
    (at a ratio of MKN45:TN2 = 1:100
    cells (colonies)) for 3 hours, and in the cells co-
    cultured with the cagE mutant (TN2ΔcagE) (at a
    ratio of MKN45:TN2ΔcagE = 1:100 cells
    (colonies)) for 3 hours, respectively.
    [ATAC-PCR]
    THP-1
    Clone TNF_1 TNF_3 MKN45
    Name ctl h h ctl Hp ΔcagE
    3NB6920014080 4 4 4.1
    ADRGL20013010 0.1 0.1 0.1 0.04 0.04 0.04
    ADRGL20067670 0 2.6 0
    ADRGL20083310 0.3 0.3 0.3
    ASTRO20032120 1.4 1.7 0.6 1.2 0 1
    ASTRO20084250 1.2 1.1 0.4 0.1 0.04 0.1
    ASTRO20152140 0.1 0.9 0.4 1.6 1.8 1.6
    ASTRO20166810 0.7 0.7 0.2 4.3 3.5 4.4
    ASTRO20181690 1.5 1.9 0.2 1.8 2.2 0.2
    BLADE20004630 3.3 2.9 2.2 0.3 0.8 0
    BRACE20006400 3.6 3.5 3.6
    BRACE20019540 0.7 0 0
    BRACE20038480 0.5 0.6 0.3 0.2 0.2 0.2
    BRACE20039040 2.5 2.2 2.3 0.1 0.7 1.1
    BRACE20039440 0.3 0.3 0.2
    BRACE20052160 2.7 2.3 1.9 1.3 0.8 1
    BRACE20053630 0.2 0.2 0 3.4 3 2.6
    BRACE20057620 0 3.7 0.5 0 0 0.3
    BRACE20058810 3.8 2 2.8 0.6 0 0.9
    BRACE20060720 0 1.3 0 0 0 0.04
    BRACE20060840 2.2 1.7 1.6 3.9 3.8 1.6
    BRACE20061740 1.9 2.1 2.7
    BRACE20062640 1.9 0.2 2.4 2.3 1.2 1
    BRACE20063780 0 0.1 0 0.4 0.2 0.2
    BRACE20067430 2.4 0 1.7 0.04 0 0
    BRACE20090440 1.1 1.8 2.2 1 0.5 1.3
    BRACE20101700 3.1 1.8 1.7 0.5 0.4 1
    BRACE20114780 1 1.5 0.6 1.2 0.4 0.2
    BRACE20151320 0 0 0.1 0.1 0.2 0
    BRACE20152870 0.6 1.3 1.5 0.4 0.3 0.3
    BRACE20163150 1.5 1.7 0.9 1.4 1.4 1.7
    BRACE20165830 2.6 4.9 3.3
    BRACE20201570 0 0 0 0 0 0
    BRACE20210140 1.7 1.4 1 1 0.6 0.5
    BRACE20223330 0.1 0 0 0 0.1 0
    BRACE20224500 0.2 0 0.2 0 0 0.1
    BRACE20229280 0.2 0.04 0.4 0 2.1 0
    BRACE20235400 1.8 0.6 1 0.3 0.6 0.1
    BRACE20266750 1.8 2.1 1 1.3 1.1 0.9
    BRACE20267250 0.8 0.8 0
    BRACE20269710 0.9 0.9 0.7 0.4 0.2 0.1
    BRALZ20018340 1.1 1 0.5 0.3 0.4 0
    BRALZ20058880 1 3.1 2.5
    BRALZ20059500 1.7 1.5 2.3
    BRALZ20064740 1.9 2.8 1.2 8.9 0 0
    BRALZ20069760 1.3 0.4 0 0.04 0.04 0.04
    BRALZ20075450 1.3 0 0 0.04 0.04 0.04
    BRALZ20088690 1.8 1.4 1.5 0 0 1.6
    BRAMY20002770 0.8 2.4 0.3 1.2 0 0
    BRAMY20004110 0.8 0 0
    BRAMY20060920 0.3 11.8 12.2
    BRAMY20103570 0 0.1 0.1 0.6 0 0
    BRAMY20144620 0.7 0 0.9
    BRAMY20152110 1.8 1.7 1.2 2.5 2.3 0.8
    BRAMY20162510 0.1 0 0 0.7 0.7 0
    BRAMY20163250 3.4 4.2 2.4 2.2 1.5 0.9
    BRAMY20163270 3.8 0.7 4.5
    BRAMY20168920 2.4 2.5 2.2 0.2 0.04 0.1
    BRAMY20178640 1.7 1.6 1.9 0.9 1 0.5
    BRAMY20184670 0.4 0.3 0.2 0.04 0.2 0.6
    BRAMY20204450 3.6 3.6 1.6 0 0 0
    BRAMY20210400 0.5 0.5 0.5 1 0.2 0.9
    BRAMY20215230 1 0.7 1.1 1.9 0.8 1
    BRAMY20218670 1.6 0 1.5 0.2 2.6 0.1
    BRAMY20229800 5 3.9 0.5 1.4 4 1
    BRAMY20229840 0.04 0 0.04 0.3 0 0.2
    BRAMY20231720 1.1 1.3 1.6
    BRAMY20247280 3.5 2.2 1.9 2 0.7 0.5
    BRAMY20261680 5.2 4 3 3.5 3.2 2.5
    BRAMY20266850 0.4 4.4 6.9 2.2 2.9 2.7
    BRAMY20267130 13.7 0 0
    BRAMY20277140 3.3 2.5 3 0.7 0.8 0
    BRAMY20280720 0 9.8 1.1
    BRAWH10000930 2.6 1.3 1.9 0 0 0
    BRAWH20015350 0 0 0
    BRAWH20017010 0.9 0 0 0.6 0.2 0.9
    BRAWH20029630 1.9 2.4 1.8 1.4 0.2 0.04
    BRAWH20100690 3.2 0.9 0.8
    BRAWH20106180 0 2.7 0.5
    BRAWH20107540 2.1 1.3 0.8 1.1 1.1 0.6
    BRAWH20110660 1.7 2.1 2.4 1.4 1.4 0.9
    BRAWH20118230 0 0 0.04 2.3 0.9 1.9
    BRAWH20122770 0 0 0.8
    BRAWH20126190 0 0 0 0 0 0
    BRAWH20132190 2.2 2.2 1 1.8 1.5 0.4
    BRAWH20138660 3.3 2.2 2.1
    BRAWH20139410 0.9 1.7 0.2 2.1 1.9 0.7
    BRAWH20155950 1.5 1.8 1.5 0.9 0 0
    BRAWH20158530 58.9 19.3 41.1
    BRCAN20060190 0.2 0 0.2
    BRCAN20147880 0.3 0.3 0 0.5 1 1.3
    BRCAN20273340 2.8 3.5 0 0.3 0.3 0.3
    BRCAN20273640 0.3 0.4 0.2 0.7 0.8 0.3
    BRCAN20275130 3.9 3.6 2.3 0.2 0 0
    BRCAN20280210 0 0 0 0.8 0 0
    BRCAN20280400 3 3.6 2.6 1.8 1.7 1
    BRCOC20021550 0.7 0 0.2 0.3 0.3 0
    BRCOC20037400 1.5 1 1.2 0.1 0 0.2
    BRCOC20105100 3.8 1 1.5
    BRHIP10001740 0.8 0.7 0.9 0.4 0 0
    BRHIP20001630 0.5 0 0
    BRHIP20096170 0 0.4 0.3
    BRHIP20103090 1 1 1.3 0.9 0 0.7
    BRHIP20105710 1.5 0 1.9 0.7 0.7 0.9
    BRHIP20110800 1.9 2.7 2.2 0.8 0 0
    BRHIP20111200 0.3 0.9 1.1
    BRHIP20118910 0 0 0
    BRHIP20129720 0 0.1 0 0 0 0
    BRHIP20143860 6.2 5.3 6.7 3.6 2.7 2.4
    BRHIP20173150 0 0.04 0 0.9 1.6 2.8
    BRHIP20175420 2.4 2.4 2.5 0.6 0 0
    BRHIP20186120 1.2 2.9 0
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    TRACH20184490 2.2 3.2 2.8 1.6 0 0
    TSTOM20001390 1.5 2.1 1.8 2.5 0.4 2.5
    TSTOM20005690 1.3 0.8 1.1 0.3 0 0.1
    UMVEN10001560 2.4 2.6 3.3 0.6 0 0.04
    UMVEN20003540 5.2 3.9 4.9 3.1 2.4 2.8
    UTERU20004240 0.04 0.2 0.1 0.04 0 0.04
    UTERU20046980 0 0 0
    UTERU20055930 2.5 3.6 2.9 2.3 1.6 2.5
    UTERU20068990 0.04 1.3 0.04 0.1 0 0
    UTERU20070810 2.7 1.9 2.4 1.9 1.3 1.1
    UTERU20115740 3.1 3.2 5 2.3 1.9 0
    UTERU20119060 0.8 1.9 0 1.9 0.3 1.6
    UTERU20124070 2 2.7 1.8 2.8 2.1 1.8
    UTERU20126880 0 2.2 0.1
    UTERU20134910 2.5 2.7 2.3 2.9 1.4 1.3
    UTERU20146680 0 0.1 0 0.5 0 0.04
    UTERU20176130 2.9 1.3 1.6 1.9 0.6 0.8
    UTERU20185230 3.1 3.2 1.8 1.6 1.1 0.6
    UTERU20186740 1.9 1.4 0.7 0.04 0 0

    Homology Search Result Data
  • Data obtained by the homology search for full-length nucleotide sequences and deduced amino acid sequences.
  • In the result of the search shown below, both units, aa and bp, are used as length units for the sequences to be compared.
  • Each data includes Clone name, Definition in hit data, P value, Length of sequence to be compared, Homology, and Accession number (No.) of hit data. These items are shown in this order and separated by a double-slash mark, //.
  • 3NB6910001910//ALANYL-TRNA SYNTHETASE (EC 6.1.1.7) (ALANINE—TRNA LIGASE) (ALARS).//3.10E-20//392aa//24%//067323
  • 3NB6920014080
  • 3NB6920014590//HOMEOBOX PROTEIN DLX-6.//1.00E-91//226aa//78%//Q98877
  • ADIPS10000640//Homo sapiens synaptic glycoprotein SC2 (SC2) mRNA, complete cds.//1.60E-169//303aa//100%//AF222742
  • ADIPS20004250//ZINC FINGER PROTEIN OZF.//6.60E-27//223aa//32%//Q15072
  • ADRGL10001470//CYTOCHROME P450 11B1 PRECURSOR (EC 1.14.15.4) (CYPXIB1) (P450C11) (STEROID 11-BETA-HYDROXYLASE).//1.60E-38//84aa//98%//P15538
  • ADRGL20000640
  • ADRGL20011190//spectrin, beta, non-erythrocytic 1 [Homo sapiens].//1.00E-36//250aa//38%//NP—003119
  • ADRGL20012870
  • ADRGL20013010
  • ADRGL20013520
  • ADRGL20018300//KINESIN LIGHT CHAIN (KLC).//1.20E-207//566aa//70%//Q07866
  • ADRGL20018540
  • ADRGL20028570//Rattus norvegicus MG87 mRNA, complete cds.//2.90E-69//250aa//53%//AF095741
  • ADRGL20035850//CYTOCHROME P450 17 (EC 1.14.99.9) (CYPXVII) (P450-C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE).//7.30E-52//99aa//100%//P05093
  • ADRGL20044590
  • ADRGL20048330//Mus musculus mRNA for granuphilin-a, complete cds.//0//673aa//89%//AB025258
  • ADRGL20061930//transposon-derived Buster1 transposase-like protein//6.00E-65//500aa//33%//NP—067034
  • ADRGL20067670
  • ADRGL20068170
  • ADRGL20068460
  • ADRGL20073570
  • ADRGL20076360
  • ADRGL20078100//NADPH:ADRENODOXIN OXIDOREDUCTASE PRECURSOR (EC 1.18.1.2) (ADRENODOXIN REDUCTASE) (FERREDOXIN-NADP(+) REDUCTASE).//3.10E-147//276aa//99%//P22570
  • ADRGL20083310
  • ASTRO10001650//DREBRIN E.//4.80E-293//540aa//99%//Q16643
  • ASTRO20001410
  • ASTRO20005330
  • ASTRO20008010//ZINC FINGER PROTEIN 85 (ZINC FINGER PROTEIN HPF4) (HTF1).//6.00E-57//143aa//70%//Q03923
  • ASTRO20012490
  • ASTRO20027430//RAS SUPPRESSOR PROTEIN 1 (RSU-1) (RSP-1 PROTEIN) (RSP-1).//2.20E-18//178aa//34%//Q15404
  • ASTRO20032120
  • ASTRO20033160//BRAIN MITOCHONDRIAL CARRIER PROTEIN-1.//2.70E-125//291aa//80%//095258
  • ASTRO20055750//Human elastin gene, exon 1.//2.70E-293//654aa//88%//M17282
  • ASTRO20058630
  • ASTRO20064750//Homo sapiens BM-003 mRNA, complete cds.//6.10E-69//214aa//64%//AF208845
  • ASTRO20072210//PERIAXIN.//2.10E-25//87aa//56%//Q63425
  • ASTRO20084250//Ciona savignyi mRNA for PEM-3, complete cds.//3.50E-56//154aa//64%//AB001769
  • ASTRO20100720
  • ASTRO20105820//ACTIN INTERACTING PROTEIN 2.//2.60E-111//392aa//56%//P46681
  • ASTRO20106150//H. sapiens mRNA for calpain-like protease.//1.80E-291//473aa//98%//Y10552
  • ASTRO20108190//TUBERIN (TUBEROUS SCLEROSIS 2 PROTEIN).//5.30E-278//513aa//100%//P49815
  • ASTRO20111490
  • ASTRO20114370//Mus musculus SMAR1 mRNA, complete cds.//1.30E-213//461aa//89%//AF235503
  • ASTRO20114610
  • ASTRO20125520//dnaj protein [Schizosaccharomyces pombe]//7.80E-37//260aa//38%//CAB59885
  • ASTRO20130500//UBIQUITIN-ACTIVATING ENZYME E1.//2.70E-157//815aa//42%//Q29504
  • ASTRO20136710
  • ASTRO20138020
  • ASTRO20141350//Mus musculus mRNA for granuphilin-b, complete cds.//7.40E-12//169aa//30%//AB025259
  • ASTRO20143630
  • ASTRO20145760//TUBULIN—TYROSINE LIGASE (EC 6.3.2.25) (TTL).//1.60E-14//233aa//27%//P38584
  • ASTRO20152140
  • ASTRO20155290
  • ASTRO20166810
  • ASTRO20168470//ZINC FINGER PROTEIN 135.//4.80E-103//289aa//59%//P52742
  • ASTRO20173480
  • ASTRO20181690//oocyte-specific protein P100//1.60E-70//554aa//36%//S23468
  • ASTRO20190390
  • BEAST20004540
  • BGGI110000240
  • BGGI110001930
  • BGGI120006160//isomerase-like protein [Arabidopsis thaliana].//1.00E-52//187aa//47%//BAB00076
  • BLADE20003400//ZINC FINGER PROTEIN 177.//2.50E-33//205aa//38%//Q13360
  • BLADE20003890//ZINC FINGER PROTEIN 135.//1.50E-264//471aa//95%//P52742
  • BLADE20004630
  • BNGH420088500
  • BRACE20003070//Rattus norvegicus neurabin mRNA, complete cds.//2.30E-40//172aa//46%//U72994
  • BRACE20006400
  • BRACE20011070//Mus musculus F-box protein FBX15 mRNA, partial cds.//9.60E-142//471aa//56%//AF176530
  • BRACE20019540
  • BRACE20027620//CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE, INDUCIBLE (EC 3.1.2.2) (LONG CHAIN ACYL-COA THIOESTER HYDROLASE) (LONG CHAIN ACYL-COA HYDROLASE) (CTE-I) (LACH2) (ACH2).//2.70E-148//423aa//65%//088267
  • BRACE20037660
  • BRACE20038000//MAP kinase phosphatase [Drosophila melanogaster].//3.80E-83//426aa//42%//BAA89534
  • BRACE20038470//Rattus norvegicus neurexophilin 4 (Nph4) mRNA, complete cds.//1.70E-57//109aa//98%//AF042714
  • BRACE20038480//Human SEC14L mRNA, complete cds.//2.60E-93//179aa//99%//D67029
  • BRACE20038850
  • BRACE20039040
  • BRACE20039440//Drosophila melanogaster CHARYBDE (charybde) mRNA, complete cds.//6.50E-17//142aa//35%//AF221109
  • BRACE20039540//MHC class I chain-related gene A protein [Homo sapiens]//2.00E-116//246aa//90%//NP—000238
  • BRACE20050900
  • BRACE20051380
  • BRACE20051690
  • BRACE20052160//Xenopus laevis bicaudal-C (Bic-C) mRNA, complete cds.//2.10E-13//208aa//30%//AF224746
  • BRACE20053280//Mus musculus Pdz-containing protein (Pdzx) mRNA, complete cds.//5.20E-63//223aa//64%//AF229645
  • BRACE20053480//Mus musculus erythroblast macrophage protein EMP mRNA, complete cds.//1.70E-133//145aa//97%//AF263247
  • BRACE20053630//BRITTLE-1 PROTEIN PRECURSOR.//1.20E-24//208aa//31%//P29518
  • BRACE20054500
  • BRACE20055180
  • BRACE20056810
  • BRACE20057190//NUCLEOPLASMIN.//5.20E-42//215aa//45%//PO5221
  • BRACE20057420
  • BRACE20057620//EUKARYOTIC TRANSLATION INITIATION FACTOR 4E (EIF-4E) (EIF4E) (MRNA CAP-BINDING PROTEIN) (EIF-4F 25 KDA SUBUNIT).//1.00E-22//60aa//73%//P48597
  • BRACE20057730//toxin sensitivity protein KTI12 homolog//1.10E-10//173aa//26%//A64492
  • BRACE20058580//Homo sapiens HCMOGT-1 mRNA for sperm antigen, complete cds.//2.10E-178//358aa//96%//AB041533
  • BRACE20058810
  • BRACE20059370//PROTEIN 4.1 (BAND 4.1) (P4.1).//6.70E-52//400aa//32%//P11171
  • BRACE20060550//ANKYRIN HOMOLOG PRECURSOR.//1.30E-14//139aa//44%//Q06527
  • BRACE20060720
  • BRACE20060840
  • BRACE20060890//ZINC FINGER PROTEIN ZIC4 (ZINC FINGER PROTEIN OF THE CEREBELLUM 4).//4.00E-131//264aa//87%//Q61467
  • BRACE20061050
  • BRACE20061740
  • BRACE20062400
  • BRACE20062640//HYPOTHETICAL 93.7 KDA PROTEIN F48E8.6 IN CHROMOSOME III.//9.10E-90//343aa//45%//Q09568
  • BRACE20062740
  • BRACE20063630
  • BRACE20063780
  • BRACE20063800
  • BRACE20063930
  • BRACE20064880//POLY(RC) BINDING PROTEIN 2 (PUTATIVE HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN X) (HNRNP X) (CTBP) (CBP).//1.80E-129//207aa//81%//Q61990
  • BRACE20067430
  • BRACE20068590//HYPOTHETICAL ZINC FINGER PROTEIN KIAA0961.//2.70E-155//504aa//56%//Q9Y2G7
  • BRACE20069090
  • BRACE20081720
  • BRACE20082950
  • BRACE20090440
  • BRACE20096200//Homo sapiens sir2-related protein type 7 (SIRT7) mRNA, complete cds.//1.00E-162//305aa//99%//AF233395
  • BRACE20096540
  • BRACE20097320
  • BRACE20099570
  • BRACE20101700
  • BRACE20101710
  • BRACE20106690
  • BRACE20106840//Rattus norvegicus partial mRNA for CRM1 protein.//9.00E-59//120aa//100%//AJ238278
  • BRACE20107530//Rattus norvegicus putative peroxisomal 2,4-dienoyl-CoA reductase (DCR-AKL) mRNA, complete cds.//1.70E-48 //108aa//91%//AF044574
  • BRACE20108130//Homo sapiens RAB-like protein 2B (RABL2B) mRNA, complete cds.//1.60E-43//92aa//100%//AF095352
  • BRACE20108880//MALEYLACETOACETATE ISOMERASE (EC 5.2.1.2) (MAAI) (GLUTATHIONE TRANSFERASE ZETA 1) (EC 2.5.1.18).//5.90E-11//27aa//100%//043708
  • BRACE20109370
  • BRACE20109830
  • BRACE20111830
  • BRACE20114780
  • BRACE20115450
  • BRACE20115920//RHO-GTPASE-ACTIVATING PROTEIN 4 (RHO-GAP HEMATOPOIETIC PROTEIN C1) (P115) (KIAA0131).//9.70E-73//291aa//52%//P98171
  • BRACE20116110
  • BRACE20116460//ATP SYNTHASE DELTA CHAIN, MITOCHONDRIAL PRECURSOR (EC 3.6.1.34).//1.00E-20//48aa//100%//P30049
  • BRACE20118380
  • BRACE20121850
  • BRACE20136240
  • BRACE20141080
  • BRACE20142320
  • BRACE20142570
  • BRACE20147800
  • BRACE20148210
  • BRACE20148240//Gsp1p [Saccharomyces cerevisiae].//1.00E-05//75aa//35%//NP—013396
  • BRACE20150310
  • BRACE20151320//Drosophila melanogaster Oregon R cytoplasmic basic protein (deltex) mRNA, complete cds.//6.10E-35//202aa//41%//U09789
  • BRACE20152870
  • BRACE20153680//Rattus norvegicus putative four repeat ion channel mRNA, complete cds.//4.10E-107//209aa//99%//AF078779
  • BRACE20154120//Shb=Src homology 2 protein//2.60E-23//79aa//48%//AAB29780
  • BRACE20163150
  • BRACE20163350//MYELIN PO PROTEIN PRECURSOR.//8.20E-08//92aa//33%//P20938
  • BRACE20165830
  • BRACE20171240
  • BRACE20172980//translation initiation factor eIF3 [Schizosaccharomyces pombe]//5.60E-06//136aa//30%//CAB11250
  • BRACE20175870
  • BRACE20177200//RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN (RAN BINDING PROTEIN 1) (RANBP1).//9.90E-32//63aa//100%//P34022
  • BRACE20179340
  • BRACE20185680//ACETYL-COENZYME A SYNTHETASE (EC 6.2.1.1) (ACETATE—COA LIGASE) (ACYL-ACTIVATING ENZYME).//1.40E-16//94aa//40%//Q01576
  • BRACE20188470//ATP-binding cassette, sub-family A member 8//1.70E-115//457aa//50%//NP—009099
  • BRACE20190040
  • BRACE20190440
  • BRACE20192440//TRANSLATION INITIATION FACTOR IF-3.//1.20E-09//161aa//26%//P47438
  • BRACE20195100
  • BRACE20201570
  • BRACE20210140
  • BRACE20220300
  • BRACE20223280
  • BRACE20223330
  • BRACE20224480
  • BRACE20224500
  • BRACE20228480
  • BRACE20229280
  • BRACE20230700
  • BRACE20232840//ATP-binding cassette, sub-family E, member 1//0//560aa//75%//NP—002931
  • BRACE20235400
  • BRACE20237270//Human WW domain binding protein-2 mRNA, complete cds.//6.10E-21//50aa//88%//U79458
  • BRACE20238000
  • BRACE20240740
  • BRACE20248260//H. sapiens PR264 mRNA.//1.50E-13//78aa//48%//X62447
  • BRACE20253160//putative trna-splicing endonuclease subunit [Schizosaccharomyces pombe]//1.10E-11//148aa//32%//CAA21061
  • BRACE20253330//Homo sapiens Na+/H+ exchange regulatory co-factor (NHERF) mRNA, complete cds.//5.50E-88//157aa//99%//AF036241
  • BRACE20257100//transcription factor (SMIF gene)//2.00E-37//110aa//94%//NP—060873
  • BRACE20262930
  • BRACE20262940
  • BRACE20266750
  • BRACE20267250
  • BRACE20269200
  • BRACE20269710
  • BRACE20273890//Human phosphotyrosine independent ligand p62B B-cell isoform for the Lck SH2 domain mRNA, partial cds.//5.70E-25//100aa//65%//U46752
  • BRACE20274080
  • BRACE20276430//Homo sapiens. retinoblastoma-associated protein RAP140 mRNA, complete cds.//4.70E-106//203aa//100%//AF180425
  • BRACE20283920
  • BRACE20284100//Homo sapiens beta-dystrobrevin (BDTN) mRNA, complete cds.//7.20E-121//237aa//100%//AF022728
  • BRACE20286360
  • BRACE20287410
  • BRALZ20013500//Homo sapiens prostate stem cell antigen (PSCA) mRNA, complete cds.//3.30E-06//122aa//32%//AF043498
  • BRALZ20014450
  • BRALZ20017430//H. sapiens mRNA for protein phosphatase 5.//1.70E-41//99aa//87%//X89416
  • BRALZ20018340//H. sapiens mRNA for glutamine transaminase K.//4.70E-93//114aa//98%//X82224
  • BRALZ20019660
  • BRALZ20054710//Mus musculus mRNA for cysteine and histidine-rich protein (Chrp gene).//1.70E-163//280aa//99%//AJ251516
  • BRALZ20058880
  • BRALZ20059500
  • BRALZ20064740
  • BRALZ20065600
  • BRALZ20069760
  • BRALZ20073760//MONOCYTE TO MACROPHAGE DIFFERENTIATION PROTEIN.//8.40E-41//76aa//69%//Q15546
  • BRALZ20075450
  • BRALZ20075760
  • BRALZ20077900//anaphase-promoting complex 1; meiotic checkpoint regulator//3.00E-91//190aa//92%//NP—073153
  • BRALZ20077930//Xenopus laevis 4g2 mRNA, complete cds.//1.20E-191//501aa//71%//AF182319
  • BRALZ20080310
  • BRALZ20088690
  • BRAMY10001300//Homo sapiens MAGE-E1b mRNA, complete cds.//5.40E-78//140aa//97%//AB040528
  • BRAMY10001570
  • BRAMY20000520//HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS C1/C2 (HNRNP C1 AND HNRNP C2).//7.10E-70//293aa//53%//P07910
  • BRAMY20000860
  • BRAMY20002770
  • BRAMY20004110
  • BRAMY20011140
  • BRAMY20025840//H. sapiens mRNA from TYL gene.//7.10E-103//198aa//98%//X99688
  • BRAMY20039260
  • BRAMY20045240
  • BRAMY20054880//Rattus norvegicus KPL2 (Kpl2) mRNA, complete cds.//1.40E-43//155aa//59%//AF102129
  • BRAMY20060920//reduced in osteosclerosis transporter//1.50E-09//60aa//53%//NP—112471
  • BRAMY20063970
  • BRAMY20071850
  • BRAMY20102080
  • BRAMY20103570
  • BRAMY20104640//Mus musculus mRNA for serine/threonine protein kinase.//1.80E-140//345aa//75%//AJ250840
  • BRAMY20110640
  • BRAMY20111960
  • BRAMY20112800
  • BRAMY20116790
  • BRAMY20120910//GRG PROTEIN (ESP1 PROTEIN) (AMINO ENHANCER OF SPLIT) (AES-1/AES-2).//1.60E-97//188aa//100%//Q08117
  • BRAMY20121190
  • BRAMY20121620//Mus musculus kinesin light chain 2 (Klc2) mRNA, complete cds.//1.80E-256//500aa//85%//AF055666
  • BRAMY20124260//Rattus norvegicus transmembrane receptor Unc5H2 mRNA, complete cds.//2.80E-286//554aa//92%//U87306
  • BRAMY20134140//ATPase, H+ transporting, lysosomal (vacuolar proton pump) 9 kD//4.60E-29//52aa//59%//NP—003936
  • BRAMY20135900//CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN.//2.00E-07//146aa//23%//P55060
  • BRAMY20136210
  • BRAMY20137560
  • BRAMY20144620
  • BRAMY20147540
  • BRAMY20148130
  • BRAMY20152110
  • BRAMY20153110//TRYPTOPHAN 5-MONOOXYGENASE (EC 1.14.16.4) (TRYPTOPHAN 5-HYDROXYLASE).//8.50E-58//201aa//58%//Q92142
  • BRAMY20157820//PUTATIVE KINESIN-LIKE PROTEIN C2F12.13.//1.10E-90//341aa//50%//014343
  • BRAMY20160700
  • BRAMY20162510//MELANOMA-ASSOCIATED ANTIGEN B2 (MAGE-B2 ANTIGEN) (DAM6).//1.30E-33//209aa//35%//015479
  • BRAMY20163250
  • BRAMY20163270
  • BRAMY20167060
  • BRAMY20167710
  • BRAMY20168920
  • BRAMY20170140
  • BRAMY20174550//Homo sapiens ATP-binding cassette protein M-ABC1 mRNA, nuclear gene encoding mitochondrial protein, complete cds.//0//648aa//98%//AF047690
  • BRAMY20178640
  • BRAMY20181220
  • BRAMY20182730
  • BRAMY20183080
  • BRAMY20184670//Homo sapiens mRNA for ALEX1, complete cds.//6.40E-14//139aa//27%//AB039670
  • BRAMY20195090
  • BRAMY20196000
  • BRAMY20204450
  • BRAMY20205740
  • BRAMY20210400//Homo sapiens thyroid hormone receptor-associated protein complex component TRAP150 mRNA, complete cds.//2.80E-16//141aa//39%//AF117756
  • BRAMY20211390//seven in absentia (Drosophila) homolog 1 [Homo sapiens]//3.70E-156//282aa//99%//NP—003022
  • BRAMY20211420//Homo sapiens mRNA for LAK-4p, complete cds.//3.00E-31//224aa//33%//AB002405
  • BRAMY20213100//Xenopus laevis Mi-2 histone deacetylase complex protein 66 mRNA, complete cds.//2.10E-66//394aa//44%//AF171099
  • BRAMY20215230
  • BRAMY20217460//Homo sapiens cardiac voltage gated potassium channel modulatory subunit mRNA, complete cds, alternatively spliced.//3.70E-81//158aa//98%//AF295530
  • BRAMY20218250//putative four repeat ion channel [Rattus norvegicus]//0//588aa//99%//AF078779
  • BRAMY20218670
  • BRAMY20229800
  • BRAMY20229840
  • BRAMY20230600
  • BRAMY20231720
  • BRAMY20240040//Homo sapiens suppressor of white apricot homolog 2 (SWAP2) mRNA, complete cds.//3.20E-301//642aa//90%//AF042800
  • BRAMY20242470//CORONIN-LIKE PROTEIN P57 (CORONIN 1A).//1.60E-70//210aa//66%//P31146
  • BRAMY20245300//Homo sapiens putative prostate cancer susceptibility protein HPC2/ELAC2 mRNA, complete cds.//0//737aa//99%//AF304370
  • BRAMY20247110//Mus musculus semaphorin cytoplasmic domain-associated protein 3A (Semcap3) mRNA, complete cds.//6.00E-117//366aa//63%//AF127084
  • BRAMY20247280
  • BRAMY20248490
  • BRAMY20250240
  • BRAMY20250320
  • BRAMY20252180
  • BRAMY20252720//Homo sapiens mRNA for thioredoxin reductase II alpha, partial cds.//1.60E-84//161aa//99%//AB019694
  • BRAMY20260910//Homo sapiens zinc finger DNA binding protein 99 (ZNF281) mRNA, complete cds.//0//811aa//99%//AF125158
  • BRAMY20261680
  • BRAMY20266850//Homo sapiens oxidation protection protein (0XR1) mRNA, complete cds.//4.50E-57//193aa//56%//AF309387
  • BRAMY20267130
  • BRAMY20268990
  • BRAMY20270730//Fugu rubripes zinc finger protein, isotocin, fatty acid binding protein, sepiapterin reductase and vasotocin genes, complete cds.//7.80E-155//398aa//66%//U90880
  • BRAMY20271400//RHO-GUANINE NUCLEOTIDE EXCHANGE FACTOR(RHOGEF) (RIP2).//0//946aa//80%//P97433
  • BRAMY20273960
  • BRAMY20277140
  • BRAMY20277170//VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV3.2 (KSHIIIA).//1.00E-290//538aa//97%//P22462
  • BRAMY20280720
  • BRAMY20284910
  • BRAMY20285160//COMPLEMENT C3 PRECURSOR [CONTAINS: C3A ANAPHYLATOXIN].//1.90E-79//148aa//100%//P01024
  • BRAMY20285930
  • BRAMY20286820
  • BRAWH10000930
  • BRAWH20002320//Manduca sexta death-associated small cytoplasmic leucine-rich protein SCLP mRNA, complete cds.//3.50E-18//167aa//31%//AF250910
  • BRAWH20004600//Mus musculus mRNA for NAKAP95, complete cds.//8.40E-184//336aa//84%//AB028921
  • BRAWH20011710//cytoplasmic linker 2//1.60E-96//316aa//59%//NP—034120
  • BRAWH20012390//Trichomonas vaginalis mRNA for centrin (ce1 gene).//4.70E-14//153aa//28%//AJ249457
  • BRAWH20012410
  • BRAWH20014920
  • BRAWH20015350
  • BRAWH20015890
  • BRAWH20016620//Homo sapiens mRNA for MOK protein kinase, complete cds.//3.40E-82//160aa//99%//AB022694
  • BRAWH20016660
  • BRAWH20016860
  • BRAWH20017010//Homo sapiens testes development-related NYD-SP22 mRNA, complete cds.//1.00E-23//56aa//92%//AF367474
  • BRAWH20018730//HYPOTHETICAL 56.4 KDA PROTEIN IN SRS2-SIP4 INTERGENIC REGION.//1.90E-46//503aa//31%//P47026
  • BRAWH20028110//Homo sapiens actin-binding double-zinc-finger protein (abLIM) mRNA, complete cds.//9.40E-168//416aa//61%//AF005654
  • BRAWH20029630//Homo sapiens bet3 (BET3) mRNA, complete cds.//2.40E-47//96aa//100%//AF041432
  • BRAWH20030250
  • BRAWH20064050//FIBULIN-1, ISOFORM C PRECURSOR.//6.30E-42//337aa//33%//P23144
  • BRAWH20075700//ZINC FINGER PROTEIN ZFP-1 (MKR1 PROTEIN).//1.60E-159//332aa//84%//P08042
  • BRAWH20096780//ZINC FINGER PROTEIN 184 (FRAGMENT).//5.00E-140//514aa//52%//Q99676
  • BRAWH20100690
  • BRAWH20101360
  • BRAWH20103180
  • BRAWH20103290//GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS (DBL'S BIG SISTER) (MCF2 TRANSFORMING SEQUENCE-LIKE PROTEIN) (KIAA0362) (FRAGMENT).//0//756aa//99%//015068
  • BRAWH20105840//HYPOTHETICAL 27.0 KDA PROTEIN IN SPOOA-MMGA INTERGENIC REGION.//1.70E-21//156aa//32%//P54527
  • BRAWH20106180
  • BRAWH20107540
  • BRAWH20110660
  • BRAWH20110790
  • BRAWH20110960//Homo sapiens mRNA for 26S proteasome subunit p40.5, complete cds.//1.50E-175//378aa//90%//AB009398
  • BRAWH20111550
  • BRAWH20112940//POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE (EC 2.4.1.41) (PROTEIN-UDP ACETYLGALACTOSAMINYLTRANSFERASE) (UDP-GALNAC:POLYPEPTIDE, N-ACETYLGALACTOSAMINYLTRANSFERASE) (GALNAC-T1).//1.10E-59//369aa//36%//Q07537
  • BRAWH20113430//COLD-INDUCIBLE RNA-BINDING PROTEIN (GLYCINE-RICH RNA-BINDING PROTEIN CIRP) (A18 HNRNP).//9.30E-52//104aa//96%//Q14011
  • BRAWH20114000//GLUTAMATE DEHYDROGENASE 1 PRECURSOR (EC 1.4.1.3) (GDH).//5.90E-233//426aa//98%//P00367
  • BRAWH20117950//LIVER CARBOXYLESTERASE PRECURSOR (EC 3.1.1.1) (PROLINE-BETA-NAPHTHYLAMIDASE).//1.80E-78//364aa//42%//Q29550
  • BRAWH20118230//BONE MORPHOGENETIC PROTEIN 7 PRECURSOR (BMP-7) (OSTEOGENIC PROTEIN 1) (OP-1).//7.60E-74//85aa//98%//P18075
  • BRAWH20121640//transporter protein; system N1 Na+ and H+-coupled glutamine transporter//1.00E-106//450aa//61%//NP—006832
  • BRAWH20122580
  • BRAWH20122770
  • BRAWH20125380//DIHYDRODIPICOLINATE SYNTHASE (EC 4.2.1.52) (DHDPS).//6.40E-15//121aa//35%//Q57695
  • BRAWH20126190
  • BRAWH20126980
  • BRAWH20128270//BH3 INTERACTING DOMAIN DEATH AGONIST (BID).//2.70E-100//195aa//99%//P55957
  • BRAWH20132190//Homo sapiens putative N-acetyltransferase Camello 2 (CML2) mRNA, complete cds.//1.80E-17//110aa//44%//AF185571
  • BRAWH20137480//actin binding LIM protein 1//2.80E-70//181aa//55%//NP—006710
  • BRAWH20138660//Homo sapiens stonin 2 mRNA, complete cds.//1.50E-171//322aa//99%//AF255309
  • BRAWH20139410
  • BRAWH20142340
  • BRAWH20147290
  • BRAWH20149340//GUANINE NUCLEOTIDE RELEASING PROTEIN (GNRP) (P140 RAS-GRF).//4.10E-129//290aa//83%//P28818
  • BRAWH20155950
  • BRAWH20158530
  • BRAWH20160280
  • BRAWH20162690
  • BRAWH20164460//TAT-BINDING HOMOLOG 7.//1.60E-95//366aa//54%//P54816
  • BRAWH20166790
  • BRAWH20171030//Homo sapiens putative helicase RUVBL mRNA, complete cds.//2.80E-209//324aa//100%//AF218313
  • BRAWH20173050
  • BRAWH20182060
  • BRAWH20185060
  • BRCAN10001490//chromobox homolog 6//2.10E-40//82aa//100%//NP—055107
  • BRCAN20003460//outer arm dynein intermediate chain 1//5.60E-57//159aa//49%//T02761
  • BRCAN20006200
  • BRCAN20006390
  • BRCAN20054490//Sus scrofa mRNA for 54 kDa vacuolar H(+)-ATPase subunit, beta isoform.//1.00E-117//229aa//96%//AJ223758
  • BRCAN20060190
  • BRCAN20064010
  • BRCAN20071190//FAF1 PROTEIN (FAS-ASSOCIATED FACTOR 1).//4.00E-225//433aa//96%//P54731
  • BRCAN20091560//Xenopus laevis mRNA for Nfr1, complete cds.//1.20E-256//605aa//77%//D86491
  • BRCAN20103740//P2X PURINOCEPTOR 7 (ATP RECEPTOR) (P2×7) (PURINERGIC RECEPTOR) (P2Z RECEPTOR).//2.20E-18//60aa//78%//Q99572
  • BRCAN20124080
  • BRCAN20126130
  • BRCAN20143700
  • BRCAN20147880
  • BRCAN20216690
  • BRCAN20224720//PROTOPORPHYRINOGEN OXIDASE (EC 1.3.3.4) (PPO).//4.40E-132//254aa//100%//P50336
  • BRCAN20237240
  • BRCAN20263400
  • BRCAN20273100
  • BRCAN20273340
  • BRCAN20273550
  • BRCAN20273640//lymphocyte specific formin related protein//3.00E-80//350aa//56%//NP—062653
  • BRCAN20275130
  • BRCAN20279700//Homo sapiens copine I mRNA, complete cds.//2.10E-32//82aa//68%//U83246
  • BRCAN20280210//H. sapiens HZF10 mRNA for zinc finger protein.//3.30E-54//219aa//49%//X78933
  • BRCAN20280360//Homo sapiens phosphatidic acid phosphohydrolase type-2c mRNA, complete cds.//8.20E-22//213aa//28%//AF047760
  • BRCAN20280400
  • BRCAN20283190//CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1 (CHD-1).//1.20E-131//235aa//99%//014646
  • BRCAN20283380//Mus musculus mRNA for serine hydrolase protein, isoform 2 (serh1 gene).//6.50E-45//103aa//80%//AJ245737
  • BRCAN20284600
  • BRCAN20285450
  • BRCOC10000870
  • BRCOC20001860//Homo sapiens endoplasmic reticulum alpha-mannosidase I mRNA, complete cds.//6.30E-154//282aa//99%//AF145732
  • BRCOC20004040//Rattus norvegicus sphingosine 1-phosphate receptor Edg-8 (Edg-8) mRNA, complete cds.//4.80E-108//265aa//81%//AF233649
  • BRCOC20004870
  • BRCOC20006370//PUTATIVE SURFACE GLYCOPROTEIN C210RF1 PRECURSOR (C210RF3).//4.00E-67//144aa//88%//P53801
  • BRCOC20008160//Homo sapiens mRNA for actin binding protein ABP620, complete cds.//4.20E-155//777aa//40%//AB029290
  • BRCOC20008500//Human ras inhibitor mRNA, 3′ end.//4.60E-229//428aa//100%//M37190
  • BRCOC20020850
  • BRCOC20021550//Rattus norvegicus mRNA for Nadrin, complete cds.//1.90E-56//247aa//55%//AB042827
  • BRCOC20023230
  • BRCOC20026640
  • BRCOC20027510//RAS SUPPRESSOR PROTEIN 1 (RSU-1) (RSP-1 PROTEIN) (RSP-1).//2.20E-18//178aa//34%//Q15404
  • BRCOC20031000
  • BRCOC20031250//TRIOSEPHOSPHATE ISOMERASE (EC 5.3.1.1) (TIM).//7.10E-38//92aa//82%//P48500
  • BRCOC20031870
  • BRCOC20035130//14-3-3 PROTEIN EPSILON (MITOCHONDRIAL IMPORT STIMULATION FACTOR L SUBUNIT) (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) (14-3-3E).//1.00E-29//71aa//88%//P42655
  • BRCOC20037320//PUTATIVE IMPORTIN BETA-4 SUBUNIT (KARYOPHERIN BETA-4 SUBUNIT).//5.00E-75//937aa//26%//060100
  • BRCOC20037400
  • BRCOC20041750
  • BRCOC20055420//GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE 2 (EC 2.3.1.97) (PEPTIDE N-MYRISTOYLTRANSFERASE 2) (MYRISTOYL-COA:PROTEIN N-MYRISTOYLTRANSFERASE 2) (NMT 2).//7.90E-229//421aa//99%//060551
  • BRCOC20059510//B. taurus myosin IB mRNA, complete CDS.//1.40E-29//117aa//53%//Z22852
  • BRCOC20074760//CDC4-LIKE PROTEIN (FRAGMENT).//4.50E-90//366aa//48%//P50851
  • BRCOC20077690
  • BRCOC20078640
  • BRCOC20090520
  • BRCOC20091960//CDC42-binding protein kinase beta (DMPK-like) [Homo sapiens]//1.50E-71//140aa//100%//NP—006026
  • BRCOC20093800
  • BRCOC20099370//Homo sapiens SPG protein (SPG) mRNA, complete cds.//0//576aa//97%//AF302154
  • BRCOC20101230////7.40E-32//227aa//35%//
  • BRCOC20105100
  • BRCOC20107300//Homo sapiens GTT1 mRNA, complete cds.//3.60E-44//90aa//98%//AF270647
  • BRCOC20110100
  • BRCOC20114180
  • BRCOC20117690
  • BRCOC20119960
  • BRCOC20121720
  • BRCOC20122290
  • BRCOC20128130
  • BRCOC20134480
  • BRCOC20135730
  • BRCOC20136750
  • BRCOC20144000//DNA REPAIR PROTEIN RAD8.//5.50E-14//111aa//36%//P36607
  • BRCOC20147480
  • BRCOC20148330
  • BRCOC20155970
  • BRCOC20158240
  • BRCOC20176520//Rattus norvegicus mRNA for type II brain 4.1, complete cds.//2.30E-127//269aa//79%//AB032827
  • BRCOC20178270//ZINC FINGER PROTEIN 83 (ZINC FINGER PROTEIN HPF1).//4.90E-101//272aa//64%//P51522
  • BRCOC20178560//PINCH PROTEIN (PARTICULARY INTERESTING NEW CYS-HIS PROTEIN).//9.50E-130//247aa//85%//P48059
  • BRHIP10001290//Homo sapiens GalNAc-T9 mRNA for UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, complete cds.//1.10E-108//299aa//63%//AB040672
  • BRHIP10001740
  • BRHIP20000870
  • BRHIP20001630
  • BRHIP20003120//Homo sapiens reticulon gene family protein (RTN3) mRNA, complete cds.//2.20E-92//190aa//98%//AF059524
  • BRHIP20005340//GAMMA-INTERFERON-INDUCIBLE PROTEIN IFI-16 (INTERFERON-INDUCIBLE MYELOID DIFFERENTIATION TRANSCRIPTIONAL ACTIVATOR).//2.10E-157//407aa//77%//Q16666
  • BRHIP20005530//UBIQUITIN-ACTIVATING ENZYME E1 1.//1.00E-59//318aa//41%//Q02053
  • BRHIP20096170//Homo sapiens cellular repressor of E1A-stimulated genes CREG mRNA, complete cds.//9.70E-35//174aa//39%//AF084523
  • BRHIP20096850//ALANINE AMINOTRANSFERASE (EC 2.6.1.2) (GLUTAMIC-PYRUVIC TRANSAMINASE) (GPT) (GLUTAMIC—ALANINE TRANSAMINASE).//1.60E-166//423aa//69%//P25409
  • BRHIP20103090//VACUOLAR ATP SYNTHASE SUBUNIT AC45 PRECURSOR (EC 3.6.1.34) (V-ATPASE AC45 SUBUNIT).//2.00E-12//82aa//47%//P40682
  • BRHIP20104440
  • BRHIP20105710
  • BRHIP20106100//GAR2 PROTEIN.//1.50E-19//199aa//31%//P41891
  • BRHIP20107440
  • BRHIP20110800
  • BRHIP20111200
  • BRHIP20115080//DYNAMIN 2 (DYNAMIN UDNM).//4.80E-63//123aa//95%//P39054
  • BRHIP20115760
  • BRHIP20118380
  • BRHIP20118910
  • BRHIP20119330//ZINC FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10) (HPF7).//6.80E-207//651aa//54%//Q05481
  • BRHIP20121410
  • BRHIP20123140
  • BRHIP20129720
  • BRHIP20132860//Homo sapiens rhophilin-like protein mRNA, complete cds.//5.40E-144//298aa//93%//AF268032
  • BRHIP20135100
  • BRHIP20137230//Homo sapiens mRNA for paralemin.//1.70E-37//352aa//35%//Y16278
  • BRHIP20139720
  • BRHIP20140630
  • BRHIP20142850
  • BRHIP20143730
  • BRHIP20143860
  • BRHIP20149540
  • BRHIP20153560
  • BRHIP20153600//Xenopus laevis RRM-containing protein SEB-4 mRNA, complete cds.//1.50E-72//148aa//93%//AF223427
  • BRHIP20167880//Mus musculus left-right dynein (Lrd) mRNA, complete cds.//8.10E-22//119aa//54%//AF183144
  • BRHIP20169680
  • BRHIP20169900
  • BRHIP20170100
  • BRHIP20173150
  • BRHIP20174040//CGMP-DEPENDENT 3′,5′-CYCLIC PHOSPHODIESTERASE (EC 3.1.4.17) (CYCLIC GMP STIMULATED PHOSPHODIESTERASE) (CGS-PDE).//0//857aa//99%//000408
  • BRHIP20175420//Mus musculus partial mRNA for stretch responsive protein 278 (sr278 gene).//6.60E-36//170aa//50%//AJ250191
  • BRHIP20176420//HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS C1/C2 (HNRNP C1 AND HNRNP C2).//9.30E-68//292aa//52%//P07910
  • BRHIP20179200
  • BRHIP20180140
  • BRHIP20183690
  • BRHIP20186120
  • BRHIP20186500
  • BRHIP20189980//FLAGELLAR WD-REPEAT PROTEIN PF20.//2.90E-41//210aa//46%//P93107
  • BRHIP20190070
  • BRHIP20191490//interferon, alpha-inducible protein 27//2.60E-36//92aa//95%//NP—005523
  • BRHIP20191770
  • BRHIP20191860//TRANSCRIPTION FACTOR 4 (IMMUNOGLOBULIN TRANSCRIPTION FACTOR 2) (ITF-2) (SL3-3 ENHANCER FACTOR 2) (SEF-2).//0//569aa//99%//P15884
  • BRHIP20194940//Homo sapiens A-kinase anchoring protein 220 mRNA, complete cds.//1.30E-23//190aa//37%//AF176555
  • BRHIP20195890//FORKHEAD BOX PROTEIN D2 (FORKHEAD-RELATED PROTEIN FKHL17) (FORKHEAD-RELATED TRANSCRIPTION FACTOR 9) (FREAC-9).//9.10E-07//104aa//31%//060548
  • BRHIP20196410
  • BRHIP20198190
  • BRHIP20205090
  • BRHIP20207430
  • BRHIP20207990
  • BRHIP20208270
  • BRHIP20208420
  • BRHIP20208590
  • BRHIP20214950
  • BRHIP20217620
  • BRHIP20218580//Mus musculus betaPix-b mRNA, complete cds.//5.10E-100//196aa//94%//AF247654
  • BRHIP20222280//ZINC FINGER PROTEIN 85 (ZINC FINGER PROTEIN HPF4) (HTF1).//1.70E-217//505aa//75%//Q03923
  • BRHIP20227080
  • BRHIP20230710
  • BRHIP20232290
  • BRHIP20233090
  • BRHIP20234380
  • BRHIP20236950
  • BRHIP20238600//WD-REPEAT PROTEIN SAZD.//3.30E-95//182aa//99%//Q12788
  • BRHIP20238690
  • BRHIP20238880
  • BRHIP20240460
  • BRHIP20243470//GALECTIN-3 (GALACTOSE-SPECIFIC LECTIN 3) (MAC-2 ANTIGEN) (IGE-BINDING PROTEIN) (35 KDA LECTIN) (CARBOHYDRATE BINDING PROTEIN 35) (CBP 35) (LAMININ-BINDING PROTEIN) (LECTIN L-29).//1.10E-16//114aa//42%//P38486
  • BRHIP20249110//hexokinase 1//0//912aa//71%//NP—000179
  • BRHIP20252450//Mus musculus Syne-1B mRNA, partial cds.//1.40E-159//980aa//33%//AF281870
  • BRHIP20253660//Rattus norvegicus mRNA for Proline Rich Synapse Associated Protein 1A (ProSAP1A gene).//1.90E-120//239aa//92%//AJ249562
  • BRHIP20254480
  • BRHIP20277620
  • BRHIP20283030//CADHERIN-RELATED TUMOR SUPPRESSOR PRECURSOR (FAT PROTEIN).//1.40E-88//881aa//29%//P33450
  • BRHIP20284800
  • BRHIP20285830//TYPE III INTERMEDIATE FILAMENT.//8.20E-10//88aa//35%//P23729
  • BRHIP20285930//Homo sapiens IL-1 receptor accessory protein mRNA, complete cds.//3.30E-08//104aa//32%//AF029213
  • BRHIP30001110
  • BRHIP30004570//P-SELECTIN PRECURSOR (GRANULE MEMBRANE PROTEIN 140) (GMP-140) (PADGEM) (CD62P) (LEUKOCYTE-ENDOTHELIAL CELL ADHESION MOLECULE 3) (LECAM3).//3.60E-32//281aa//31%//Q01102
  • BRHIP30004880//H. sapiens mRNA for titin protein (clone hh1-hh54).//9.60E-85//812aa//26%//X90568
  • BRSSN10000920
  • BRSSN20003120//METABOTROPIC GLUTAMATE RECEPTOR PRECURSOR.//7.00E-08//257aa//22%//P91685
  • BRSSN20006340
  • BRSSN20013420//histone deacetylase 6 [Homo sapiens] //0//811aa//99%//NP—006035
  • BRSSN20014260//RIBONUCLEASE INHIBITOR.//1.70E-10//195aa//29%//P29315
  • BRSSN20015030
  • BRSSN20015790//ORNITHINE DECARBOXYLASE (EC 4.1.1.17) (ODC).//9.00E-102//352aa//53%//P00860
  • BRSSN20018690//Homo sapiens NY-REN-25 antigen mRNA, partial cds.//9.30E-41//88aa//100%//AF155103
  • BRSSN20021600//RING CANAL PROTEIN (KELCH PROTEIN).//3.60E-59//510aa//31%//Q04652
  • BRSSN20028570
  • BRSSN20038200//RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2 (RALGDS-LIKE FACTOR) (RAS-ASSOCIATED PROTEIN RAB2L).//3.90E-18//458aa//25%//015211
  • BRSSN20038410
  • BRSSN20039370//ZINC FINGER PROTEIN 7 (ZINC FINGER PROTEIN KOX4) (ZINC FINGER PROTEIN HF. 16).//2.50E-38//94aa//52%//P17097
  • BRSSN20043040
  • BRSSN20046570
  • BRSSN20046790//ZINC FINGER PROTEIN 135.//8.60E-81//231aa//60%//P52742
  • BRSSN20046860
  • BRSSN20066110//Homo sapiens mRNA for mucolipidin, short form (ML4 gene).//1.70E-26//121aa//49%//AJ293659
  • BRSSN20097020
  • BRSSN20101100//GRG PROTEIN (ESP1 PROTEIN) (AMINO ENHANCER OF SPLIT) (AES-1/AES-2).//2.50E-10//70aa//51%//Q08117
  • BRSSN20105870
  • BRSSN20105960
  • BRSSN20108300
  • BRSSN20117990
  • BRSSN20120810//SERINE PROTEASE HEPSIN (EC 3.4.21.-) (TRANSMEMBRANE PROTEASE, SERINE 1).//9.80E-144//254aa//100%//P05981
  • BRSSN20121030
  • BRSSN20137020
  • BRSSN20142940
  • BRSSN20146100//ADENYLATE CYCLASE, OLFACTIVE TYPE (EC 4.6.1.1) (ADENYLATE CYCLASE TYPE III) (ATP PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE).//0//389aa//90%//P21932
  • BRSSN20151990
  • BRSSN20152380
  • BRSSN20159070
  • BRSSN20159820
  • BRSSN20169050
  • BRSSN20176820//Mus musculus p300 transcriptional cofactor JMY mRNA, complete cds.//8.50E-297//640aa//89%//AF201390
  • BRSSN20177570
  • BRSSN20187310//ANKYRIN 1 (ERYTHROCYTE ANKYRIN) (ANKYRIN R) (ANKYRINS 2.1 AND 2.2).//3.20E-26//306aa//30%//P16157
  • BRSTN10000830
  • BRSTN20000580
  • BRSTN20002200
  • BRSTN20005360//TRANSLATION INITIATION FACTOR IF-2.//1.20E-07//205aa//26%//060841
  • BRTHA20000570
  • BRTHA20004740//HYPOTHETICAL 41.6 KDA PROTEIN IN IMP1-HLJ1INTERGENIC REGION (RF1095).//1.60E-16//310aa//27%//P28625
  • BRTHA20046290//NOVEL ANTIGEN 2 (NAG-2) (TSPAN-4).//7.30E-84//153aa//100%//014817
  • BRTHA20046390
  • BRTHA20046420 CD34C30001250 CD34C30003140 CD34C30004240//H. sapiens graf gene.//1.10E-140//270aa//100%//Y10388 CD34C30004940
  • COLON10001350//IG ALPHA-1 CHAIN C REGION.//1.70E-196//353aa//99%//P01876
  • COLON20043180
  • COLON20093370
  • CTONG10000100//GUFA PROTEIN.//2.10E-31//156aa//45%//Q06916
  • CTONG10000220//Mus musculus cerebellar postnatal development protein-1 (Cpd1) mRNA, partial cds.//1.80E-101//220aa//90%//U89345
  • CTONG10000620
  • CTONG10000930
  • CTONG10000940//CYCLIN-DEPENDENT KINASE 6 INHIBITOR(P18-INK6) (CYCLIN-DEPENDENT KINASE 4 INHIBITOR C) (P18-INK4C).//7.20E-13//131aa//35%//Q60772
  • CTONG10001650
  • CTONG10002770//PLECTIN.//2.00E-49//284aa//28%//P30427
  • CTONG20002180
  • CTONG20004690//CYTOCHROME B561 (CYTOCHROME B-561).//2.80E-50//101aa//100%//P49447
  • CTONG20009770//26S PROTEASOME REGULATORY SUBUNIT S2 (P97) (TUMOR NECROSIS FACTOR TYPE 1 RECEPTOR ASSOCIATED PROTEIN 2) (55.11 PROTEIN).//0//908aa//99%//Q13200
  • CTONG20014280//Xenopus laevis fizzy1 mRNA, complete cds.//2.00E-82//479aa//38%//AF034578
  • CTONG20027090
  • CTONG20028410
  • CTONG20038890
  • CTONG20049410
  • CTONG20050280//ZINC FINGER PROTEIN ZFP-36 (FRAGMENT).//8.00E-149//490aa//55%//P16415
  • CTONG20052650//BYSTIN.//5.10E-60//120aa//99%//Q13895
  • CTONG20052900//FASCIN (ACTIN BUNDLING PROTEIN).//7.30E-257//437aa//98%//Q16658
  • CTONG20075860//Homo sapiens mRNA for SPIN protein.//3.90E-123//204aa//69%//Y14946
  • CTONG20076130//ZINC FINGER PROTEIN 185 (LIM-DOMAIN PROTEIN ZNF185) (P1-A).//1.10E-158//327aa//89%//015231
  • CTONG20077790
  • CTONG20082690
  • CTONG20085950//ZINC FINGER PROTEIN 191.//5.80E-91//346aa//53%//014754
  • CTONG20091080//HOMEOBOX PROTEIN DLX-1.//1.00E-54//134aa//84%//Q64317
  • CTONG20091320
  • CTONG20092570//Rattus norvegicus neural membrane protein 35 mRNA, complete cds.//1.00E-55//300aa//49%//AF044201
  • CTONG20092580
  • CTONG20092680//Rattus norvegicus protein associating with small stress protein PASS1 (Pass1) mRNA, complete cds.//1.40E-11//98aa//40%//AF168362
  • CTONG20092700//Mus musculus transcriptional repressor RP58 (rp58) mRNA, complete cds.//6.60E-18//162aa//35%//AF140224
  • CTONG20093950//Mus musculus zfh-4 mRNA for zinc-finger homeodomain protein 4, complete cds.//0//473aa//90%//AB024499
  • CTONG20095270
  • CTONG20095290
  • CTONG20095340//PROBABLE CATION-TRANSPORTING ATPASE WO8D2.5 IN CHROMOSOME IV (EC 3.6.1.-).//3.90E-134//500aa//37%//Q27533
  • CTONG20096430
  • CTONG20096750
  • CTONG20097660
  • CTONG20098440
  • CTONG20099380
  • CTONG20099550//TRICHOHYALIN.//4.20E-16//534aa//25%//Q07283
  • CTONG20099630
  • CTONG20100240//Mus musculus radial spokehead-L protein (Rshl1) mRNA, complete cds.//1.60E-185//520aa//63%//AF329192
  • CTONG20101480
  • CTONG20103480
  • CTONG20105080
  • CTONG20105660
  • CTONG20106230
  • CTONG20106520//THREONINE SYNTHASE (EC 4.2.99.2).//6.70E-77//347aa//40%//Q42598
  • CTONG20108210
  • CTONG20114290//PUTATIVE IMPORTIN BETA-4 SUBUNIT (KARYOPHERIN BETA-4 SUBUNIT).//1.30E-75//937aa//27%//060100
  • CTONG20114740//Homo sapiens NY-REN-57 antigen mRNA, partial cds.//1.70E-37//72aa//100%//AF155114
  • CTONG20118150//HYPOTHETICAL 100.6 KDA TRP-ASP REPEATS CONTAINING PROTEIN C1672.07 IN CHROMOSOME III.//2.10E-150//910aa//36%//014053
  • CTONG20118250//CARBONIC ANHYDRASE (EC 4.2.1.1) (CARBONATE DEHYDRATASE).//3.30E-88//257aa//62%//Q92051
  • CTONG20119200//Homo sapiens NY-REN-57 antigen mRNA, partial cds.//1.00E-18//41aa//100%//AF155114
  • CTONG20120770
  • CTONG20121010//ZINC FINGER PROTEIN 29 (ZFP-29).//7.80E-131//380aa//58%//Q07230
  • CTONG20121580//KINESIN-LIKE PROTEIN KIF1A.//3.50E-148//395aa//59%//P33173
  • CTONG20124010
  • CTONG20124220//STEROL REGULATORY ELEMENT BINDING PROTEIN-1 (SREBP-1) (STEROL REGULATORY ELEMENT-BINDING TRANSCRIPTION FACTOR 1).//0//691aa//98%//P36956
  • CTONG20124470
  • CTONG20124730
  • CTONG20125540//PTB-ASSOCIATED SPLICING FACTOR (PSF).//6.90E-07//144aa//29%//P23246
  • CTONG20125640//60S ACIDIC RIBOSOMAL PROTEIN PO (L10E).//7.50E-137//306aa//89%//P05388
  • CTONG20126070
  • CTONG20127450//H. sapiens mRNA for Ndr protein kinase.//4.50E-11//37aa//89%//Z35102
  • CTONG20128430//Human non-lens beta gamma-crystallin like protein (AIM1) mRNA, partial cds.//8.40E-127//616aa//40%//U83115
  • CTONG20128470
  • CTONG20129960//Mus musculus F-box protein FBX18 mRNA, partial cds.//0//905aa//92%//AF184275
  • CTONG20131490
  • CTONG20131560//NEUROBLAST DIFFERENTIATION ASSOCIATED PROTEIN AHNAK (DESMOYOKIN) (FRAGMENTS).//0//632aa//99%//Q09666
  • CTONG20132220
  • CTONG20133390//ZINC FINGER PROTEIN 135.//1.00E-139//416aa//57%//P52742
  • CTONG20133480
  • CTONG20133520//ZINC FINGER PROTEIN 228.//1.50E-163//670aa//50%//Q9UJU3
  • CTONG20136300
  • CTONG20138030
  • CTONG20139070
  • CTONG20139340
  • CTONG20139860//Homo sapiens nasopharyngeal carcinoma susceptibility protein LZ16 mRNA, complete cds.//3.50E-17//162aa//36%//AF121775
  • CTONG20140320
  • CTONG20140580//HepA-related protein//8.80E-61//345aa//42%//NP—054859
  • CTONG20141650
  • CTONG20143690
  • CTONG20146300
  • CTONG20146970
  • CTONG20147050
  • CTONG20149460//RING CANAL PROTEIN (KELCH PROTEIN).//1.20E-56//556aa//27%//Q04652
  • CTONG20149950
  • CTONG20150910
  • CTONG20153300//H. sapiens mRNA for tre oncogene (clone 210).//4.80E-214//259aa//78%//X63546
  • CTONG20153580//Homo sapiens leucine-rich repeats containing F-box protein FBL3 mRNA, complete cds.//4.80E-37//326aa//28%//AF186273
  • CTONG20155180
  • CTONG20155400
  • CTONG20156780//Rattus norvegicus PGC1 mRNA for PPAR gamma coactivator, complete cds.//1.80E-72//176aa//46%//AB025784
  • CTONG20158040//UDP-N-ACETYLGLUCOSAMINE PYROPHOSPHORYLASE (EC 2.7.7.23) (ANTIGEN X) (AGX) (AGX-1) (SPERM-ASSOCIATED ANTIGEN 2).//4.90E-126//376aa//61%//Q16222
  • CTONG20158150
  • CTONG20158660//Rattus norvegicus mRNA for seven transmembrane receptor, complete cds.//5.90E-99//632aa//36%//AB019120
  • CTONG20159530//GLYPICAN-1 PRECURSOR.//3.40E-118//222aa//100%//P35052
  • CTONG20160560
  • CTONG20161850
  • CTONG20162170
  • CTONG20163550
  • CTONG20164990
  • CTONG20165050
  • CTONG20186320//RING CANAL PROTEIN (KELCH PROTEIN).//3.70E-19//290aa//26%//Q04652
  • CTONG20200310//mitotic control protein dis3 homolog//1.20E-113//655aa//36%//JE0110
  • CTONG20265130
  • CTONG20267700
  • CTONG20273610
  • D3OST10001090
  • D3OST10002670
  • D3OST10002700
  • D3OST20006180//Drosophila melanogaster slingshot mRNA, complete cds.//9.20E-114//358aa//56%//AB036834
  • D3OST20006540
  • D3OST20007340
  • D3OST20013280//ARP2/3 COMPLEX 16 KDA SUBUNIT (P16-ARC).//1.10E-48//103aa//99%//015511
  • D3OST20024170
  • D3OST20024360//Homo sapiens neuroendocrine differentiation factor mRNA, complete cds.//4.70E-35//80aa//100%//AF219226
  • D3OST20024520
  • D3OST20036070
  • D3OST20037970
  • D3OST20038560
  • D3OST30002580
  • D3OST30002910
  • D6OST20003580//H. sapiens mRNA for aminopeptidase P-like.//7.40E-70//103aa//99%//X95762
  • D6OST20004450
  • D6OST20005070
  • D9OST20000310
  • D9OST20002780
  • D9OST20015470//Mus musculus MPS1 gene and mRNA, 3′end.//4.60E-147//329aa//79%//L20315
  • D9OST20023970//CARTILAGE GLYCOPROTEIN-39 PRECURSOR (GP-39) (39 KDA SYNOVIAL PROTEIN) (YKL-40) (CHITINASE-3 LIKE 1).//1.30E-17//44aa//90%//P36222
  • D9OST20026730//Homo sapiens caspase recruitment domain protein 7 mRNA, complete cds.//2.40E-141//524aa//40%//AF298548
  • D9OST20031370//Homo sapiens mRNA for partial putative TCPTP-interacting protein (ptpip5 gene).//3.40E-39//176aa//48%//AJ242719
  • D9OST20033970//ZINC FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10) (HPF7).//2.50E-152//541aa//52%//Q05481
  • D9OST20035800
  • D9OST20035940//BRAIN MITOCHONDRIAL CARRIER PROTEIN-1.//9.10E-93//216aa//80%//095258
  • D9OST20040180//OLFACTORY RECEPTOR-LIKE PROTEIN OLF4.//1.20E-106//301aa//64%//Q95157
  • DFNES10000030
  • DFNES10001850
  • DFNES20001530//ATAXIN 7 (SPINOCEREBELLAR ATAXIA TYPE 7 PROTEIN).//2.30E-25//98aa//57%//015265
  • DFNES20010910
  • DFNES20014040//TRICHOHYALIN.//1.70E-17//380aa//26%//P37709
  • DFNES20025880
  • DFNES20031920//Drosophila melanogaster mRNA for fucosyltransferase homologue (FucTB gene).//8.40E-18//133aa//36%//AJ302046
  • DFNES20037420//G1 TO S PHASE TRANSITION PROTEIN 1 HOMOLOG (GTP-BINDING PROTEIN GST1-HS).//1.00E-274//499aa//99%//P15170
  • DFNES20055270
  • DFNES20071130//PHOSPHOTRIESTERASE RELATED PROTEIN (PARATHION HYDROLASE-RELATED PROTEIN).//4.40E-141//233aa//86%//Q60866
  • DFNES20082800
  • FCBBF10000240
  • FCBBF10000380
  • FCBBF10000630//Homo sapiens huntingtin interacting protein HYPB mRNA, partial cds.//3.70E-16//36aa//100%//AF049610
  • FCBBF10000770//Homo sapiens REC8 mRNA, partial cds.//6.10E-266//528aa//96%//AF132734
  • FCBBF10001150//Homo sapiens protocadherin beta 14 (PCDH-beta14) mRNA, complete cds.//4.10E-308//717aa//79%//AF152493
  • FCBBF10001210//Homo sapiens mRNA for SHPS-1, complete cds.//6.90E-22//135aa//43%//D86043
  • FCBBF10001550
  • FCBBF10001710//ZINC FINGER PROTEIN 83 (ZINC FINGER PROTEIN HPF1).//1.90E-131//397aa//59%//P51522
  • FCBBF10001820//CITRATE LYASE BETA CHAIN (EC 4.1.3.6) (CITRASE) (CITRYL-COA LYASE SUBUNIT) (EC 4.1.3.34).//3.70E-32//294aa//27%//053078
  • FCBBF10002430
  • FCBBF10002700
  • FCBBF10002800
  • FCBBF10003220
  • FCBBF10003670//QUEUINE TRNA-RIBOSYLTRANSFERASE (EC 2.4.2.29) (TRNA-GUANINE TRANSGLYCOSYLASE) (GUANINE INSERTION ENZYME).//2.60E-195//308aa//100%//P54578
  • FCBBF10003740
  • FCBBF10003760
  • FCBBF10003770//Homo sapiens mRNA for GRIP1 protein.//0//572aa//99%//AJ133439
  • FCBBF10004120
  • FCBBF10004370//ZINC FINGER PROTEIN 33A (ZINC FINGER PROTEIN KOX31) (KIAA0065) (HA0946) (FRAGMENT).//3.30E-96//292aa//52%//Q06730
  • FCBBF10005060//CELLULAR RETINALDEHYDE-BINDING PROTEIN (CRALBP).//8.40E-51//260aa//41%//P10123
  • FCBBF10005460//Mus musculus putative neuronal cell adhesion molecule (Punc) mRNA, complete cds.//9.20E-275//484aa//94%//AF026465
  • FCBBF10005500
  • FCBBF10005740//MITOCHONDRIAL CARRIER PROTEIN YMC2 PRECURSOR.//1.10E-27//194aa//38%//P38087
  • FCBBF20006780
  • FCBBF20014270//ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR) (DBI) (ENDOZEPINE) (EP).//1.40E-34//85aa//81%//P45882
  • FCBBF20023700
  • FCBBF20032970
  • FCBBF20035280
  • FCBBF20042170//Homo sapiens NIBAN mRNA, complete cds.//1.90E-177//345aa//100%//AB050477
  • FCBBF20042560
  • FCBBF20049300//NEURONAL OLFACTOMEDIN-RELATED ER LOCALIZED PROTEIN PRECURSOR (NOEL) (1B426B).//7.70E-64//187aa//63%//Q62609
  • FCBBF20051220
  • FCBBF20054280
  • FCBBF20056370
  • FCBBF20059090//ZINC FINGER PROTEIN 44 (ZINC FINGER PROTEIN KOX7) (FRAGMENT).//2.00E-08//96aa//34%//P15621
  • FCBBF20064520//HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS C1/C2 (HNRNP C1 AND HNRNP C2).//5.50E-70//293aa//53%//P07910
  • FCBBF20067810//SPOOB-ASSOCIATED GTP-BINDING PROTEIN.//1.30E-51//275aa//42%//P20964
  • FCBBF20068820//ZINC FINGER PROTEIN 83 (ZINC FINGER PROTEIN HPF1).//1.50E-74//216aa//62%//P51522
  • FCBBF20071860
  • FCBBF20072650
  • FCBBF20075560
  • FCBBF20076330
  • FCBBF30001840
  • FCBBF30007680//Homo sapiens general transcription factor 2-I (GTF2I) mRNA, alternatively spliced product, complete cds.//4.80E-56//141aa//72%//AF038968
  • FCBBF30008470
  • FCBBF30010810//ZINC FINGER PROTEIN 85 (ZINC FINGER PROTEIN HPF4) (HTF1).//7.10E-173//436aa//70%//Q03923
  • FCBBF30012350//CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II GAMMA CHAIN (CAM-KINASE II GAMMA CHAIN) (EC 2.7.1.123) (CAMK-II, GAMMA SUBUNIT).//8.80E-143//291aa//92%//P11730
  • FCBBF30012810//Homo sapiens ubiquitin-specific processing protease mRNA, complete cds.//1.10E-123//450aa//49%//AF229438
  • FCBBF30013770//Rattus norvegicus dnchc2 mRNA for cytoplasmic dynein heavy chain, complete cds.//0//806aa//93%//AB041881
  • FCBBF30015940//Chlamydomonas reinhardtii dhc1 gene for 1-alpha dynein heavy chain.//4.90E-228//831aa//52%//AJ243806
  • FCBBF30016320
  • FCBBF30016570
  • FCBBF30018550//Homo sapiens putative zinc finger protein mRNA, complete cds.//9.40E-90//560aa//35%//AF251039
  • FCBBF30019120
  • FCBBF30024750//SEMAPHORIN 4F PRECURSOR (SEMAPHORIN W) (SEMA W).//2.00E-73//129aa//100%//095754
  • FCBBF30025560//NERVOUS-SYSTEM SPECIFIC OCTAMER-BINDING TRANSCRIPTION FACTOR N-OCT 3 (BRAIN-SPECIFIC HOMEOBOX/POU DOMAIN PROTEIN 2) (BRN-2 PROTEIN) [CONTAINS: N-OCT 5A; N-OCT 5B].//4.30E-171//203aa//100%//P20265
  • FCBBF30028180
  • FCBBF30033050
  • FCBBF30039020//GROWTH-ARREST-SPECIFIC PROTEIN 2.//1.80E-68//194aa//64%//043903
  • FCBBF30049550//ANKYRIN 2 (BRAIN ANKYRIN) (ANKYRIN B) (ANKYRIN, NONERYTHROID).//0//1016aa//99%//Q01484
  • FCBBF30052180
  • FCBBF30054440
  • FCBBF30057290//Homo sapiens GIOT-4 mRNA for gonadotropin inducible transcription repressor-4, complete cds.//8.90E-258//642aa//68%//AB021644
  • FCBBF30062880
  • FCBBF30070770
  • FCBBF30071520
  • FCBBF30078290
  • FCBBF30083620//PLEXIN 4 PRECURSOR (TRANSMEMBRANE PROTEIN SEX).//5.80E-146//344aa//77%//P51805
  • FCBBF30083820//Homo sapiens C2H2 (Kruppe1-type) zinc finger protein mRNA, complete cds.//1.50E-14//142aa//38%//AF159567
  • FCBBF30086440
  • FCBBF30090690//Homo sapiens HT017 mRNA, complete cds.//8.60E-54//311aa//38%//AF225421
  • FCBBF30095260
  • FCBBF30123470
  • FCBBF30129630//ZINC FINGER PROTEIN 85 (ZINC FINGER PROTEIN HPF4) (HTF1).//9.50E-98//228aa//73%//Q03923
  • FCBBF30170590
  • FCBBF30172550
  • FCBBF30175310//ETHANOLAMINEPHOSPHOTRANSFERASE (EC 2.7.8.1) (ETHPT).//2.10E-38//401aa//28%//P22140
  • FCBBF30178730
  • FCBBF30189490
  • FCBBF30190850//E-SELECTIN PRECURSOR (ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1) (ELAM-1) (LEUKOCYTE-ENDOTHELIAL CELL ADHESION MOLECULE 2) (LECAM2) (CD62E).//6.10E-30//275aa//31%//P16581
  • FCBBF30195640//Homo sapiens ALR-like protein mRNA, complete cds.//9.10E-188//331aa//99%//AF264750
  • FCBBF30199610
  • FCBBF30215060
  • FCBBF30225660
  • FCBBF30233680
  • FCBBF30238870//PROTEIN KINASE C-BINDING PROTEIN NELL2 PRECURSOR (NEL-LIKE PROTEIN 2).//O//641aa//99%//Q99435
  • FCBBF30240020
  • FCBBF30240960//ZINC FINGER PROTEIN 136.//8.30E-131//338aa//65%//P52737
  • FCBBF30242250
  • FCBBF30243640//PROTEIN ARGININE N-METHYLTRANSFERASE 2 (EC 2.1.1.-).//6.40E-53//102aa//100%//P55345
  • FCBBF30246230//Homo sapiens C2H2 (Kruppe1-type) zinc finger protein mRNA, complete cds.//7.10E-17//141aa//40%//AF159567
  • FCBBF30246630//H. sapiens mRNA for ZYG homologue.//4.80E-60//562aa//29%//X99802
  • FCBBF30247930//Rattus norvegicus clone C42 CDK5 activator-binding protein mRNA, complete cds.//2.70E-73//162aa//87%//AF177477
  • FCBBF30250730//TRICHOHYALIN.//1.30E-10//240aa//27%//P22793
  • FCBBF30251420
  • FCBBF30252520//Homo sapiens bicaudal-D (BICD) mRNA, alternatively spliced, partial cds.//2.50E-47//103aa//98%//U90030
  • FCBBF30252800//NDRG1 PROTEIN (DIFFERENTIATION-RELATED GENE 1 PROTEIN) (DRG1) (REDUCING AGENTS AND TUNICAMYCIN-RESPONSIVE PROTEIN) (RTP) (NICKEL-SPECIFIC INDUCTION PROTEIN CAP43).//1.30E-134//260aa//97%//Q92597
  • FCBBF30252850//Mus musculus peripherial benzodiazepine receptor associated protein (Pap7) mRNA, complete cds.//2.90E-46//185aa//50%//AF022770
  • FCBBF30262360
  • FCBBF30262510
  • FCBBF30266780
  • FCBBF30266920
  • FCBBF30278630
  • FCBBF30279030//Homo sapiens BNPI mRNA for brain-specific Na-dependent inorganic phosphate cotransporter, complete cds.//2.40E-120//222aa//100%//AB032436
  • FCBBF30281880//regulator of G-protein signalling 7 [Homo sapiens].//2.00E-05//100aa//33%//NP—002915
  • FCBBF30284720
  • FCBBF30285280
  • FCBBF40001420
  • FCBBF40001730//GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT-LIKE PROTEIN 12.3 (P205) (RECEPTOR OF ACTIVATED PROTEIN KINASE C 1) (RACK1).//4.20E-120//265aa//84%//P25388
  • FCBBF40005480
  • FEBRA10001880//Homo sapiens serine/threonine kinase mRNA, complete cds.//4.60E-106//344aa//53%//AF005046
  • FEBRA10001900
  • FEBRA20002100//D-XYLOSE-PROTON SYMPORTER (D-XYLOSE TRANSPORTER).//2.00E-13//159aa//27%//052733
  • FEBRA20003210
  • FEBRA20004620//RAP1 GTPASE ACTIVATING PROTEIN 1 (RAP1GAP).//1.50E-46//208aa//43%//P47736
  • FEBRA20007620//PUTATIVE PRE-mRNA SPLICING FACTOR ATP-DEPENDENT RNA HELICASE SPBC16H, 5.10; C.//2.30E-126//692aa//39%//042945
  • FEBRA20009090
  • FEBRA20010120//CLEAVAGE STIMULATION FACTOR, 64 KDA SUBUNIT (CSTF 64 KDA SUBUNIT) (CF-1 64 KDA SUBUNIT).//1.10E-73//137aa//97%//P33240
  • FEBRA20017050
  • FEBRA20018280
  • FEBRA20018690//ZINC FINGER PROTEIN 44 (ZINC FINGER PROTEIN KOX7) (FRAGMENT).//2.00E-08//96aa//34%//P15621
  • FEBRA20024100//Rattus norvegicus myosin heavy chain Myr 8 mRNA, complete cds.//0//863aa//78%//AF209114
  • FEBRA20025270
  • FEBRA20025520
  • FEBRA20026110//ZINC FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10) (HPF7).//1.10E-217//810aa//48%//Q05481
  • FEBRA20026280
  • FEBRA20027810
  • FEBRA20029860
  • FEBRA20034360
  • FEBRA20034680//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//5.60E-93//481aa//35%//P51523
  • FEBRA20037260
  • FEBRA20037500
  • FEBRA20040530//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//3.30E-115//335aa//54%//P51523
  • FEBRA20042190
  • FEBRA20052910
  • FEBRA20060610
  • FEBRA20072120
  • FEBRA20079310
  • FEBRA20080810//Rattus norvegicus mRNA for peptide/histidine transporter, complete cds.//1.30E-107//239aa//87%//AB000280
  • FEBRA20082010//ZINC FINGER PROTEIN 195.//0//482aa//99%//014628
  • FEBRA20082100
  • FEBRA20086620//NEURONAL OLFACTOMEDIN-RELATED ER LOCALIZED PROTEIN PRECURSOR (NOEL) (1B426B).//3.80E-165//453aa//65%//Q62609
  • FEBRA20088360//ALPHA-ADAPTIN C (CLATHRIN ASSEMBLY PROTEIN COMPLEX 2 ALPHA-C LARGE CHAIN) (100 KDA COATED VESICLE PROTEIN C) (PLASMA MEMBRANE ADAPTOR HA2/AP2 ADAPTIN ALPHA C SUBUNIT).//5.60E-05//58aa//53%//P17427
  • FEBRA20090290
  • FEBRA20092890//Rattus norvegicus neural cell adhesion protein BIG-2 precursor (BIG-2) mRNA, complete cds.//0//697aa//93%//U35371
  • FEBRA20093520
  • FEBRA20095140
  • FEBRA20095880
  • FEBRA20097310//Human Hsp27 ERE-TATA-binding protein (HET) mRNA, complete cds.//0//597aa//97%//U72355
  • FEBRA20098460
  • FEBRA20111460
  • FEBRA20113560//R. norvegicus mRNA for DRM protein.//5.10E-65//157aa//80%//Y10019
  • FEBRA20125070
  • FEBRA20130190//UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3//8.20E-65//345aa//42%//NP—055071
  • FEBRA20132740//Homo sapiens mRNA for CDEP, complete cds.//3.70E-16//40aa//92%//AB008430
  • FEBRA20140100//RER1 PROTEIN.//3.20E-106//196aa//99%//015258
  • FEBRA20144170//RIBOSOMAL PROTEIN S6 KINASE II ALPHA 2 (EC 2.7.1.-) (S6KII-ALPHA 2) (P90-RSK 2) (RIBOSOMAL S6 KINASE 3) (RSK3) (PP90RSK3).//1.30E-269//495aa//99%//Q15349
  • FEBRA20145780
  • FEBRA20161120
  • FEBRA20166540
  • FEBRA20167390//Mus musculus ST6GalNAc V mRNA for GD1 alpha synthase, complete cds.//9.40E-64//134aa//91%//AB030836
  • FEBRA20171380//ZINC FINGER PROTEIN 33A (ZINC FINGER PROTEIN KOX31) (KIAA0065) (HA0946) (FRAGMENT).//6.30E-127//415aa//48%//Q06730
  • FEBRA20174410//Mus musculus mRNA for nuclear protein ZAP, complete cds.//2.30E-193//543aa//69%//AB033168
  • FEBRA20176800
  • FEBRA20184330//Rattus norvegicus glutamate receptor interacting protein 2 (GRIP2) mRNA, complete cds.//8.10E-72//161aa//88%//AF072509
  • FEBRA20192420
  • FEBRA20195820//ZINC FINGER PROTEIN 132.//2.60E-47//134aa//63%//P52740
  • FEBRA20196370
  • FEBRA20196630//RNA helicase-related protein//0//317aa//100%//NP—031398
  • FEBRA20197110
  • FEBRA20204000
  • FEBRA20204060
  • FEBRA20211710
  • FEBRA20214970
  • FEBRA20215500//Mus musculus Nulp1 (nulp1) mRNA, complete cds.//1.80E-38//146aa//64%//U94988
  • FEBRA20216360
  • FEBRA20222040
  • FEBRA20223220//Homo sapiens mRNA for fibulin-4.//9.20E-110//202aa//100%//AJ132819
  • FEBRA20225040//high-glucose-regulated protein 8//1.40E-110//514aa//51%//NP—057342
  • FEBRA20226010
  • FEBRA20229560
  • FEBRA20229630
  • FEBRA20232850
  • FEBRA20233770//NEURONAL PAS DOMAIN PROTEIN 2 (NEURONAL PAS2) (MEMBER OF PAS PROTEIN 4) (MOP4).//6.30E-62//164aa//81%//Q99743
  • FEBRA20235500//P3 PROTEIN.//5.20E-74//391aa//39%//P09131
  • FEBRA20237640//Rattus norvegicus neurabin mRNA, complete cds.//9.10E-29//172aa//46%//U72994
  • FEHRT20003250//PHOSPHATIDYLINOSITOL 4-KINASE ALPHA (EC 2.7.1.67) (PI4-KINASE) (PTDINS-4-KINASE) (PI4K-ALPHA).//2.20E-146//269aa//100%//P42356
  • FELNG20002410
  • HCASM10000500//TOPOISOMERASE 1-RELATED PROTEIN TRF5.//3.70E-09//193aa//22%//P48561
  • HCHON10001760//histone deacetylase 5//1.00E-133//320aa//67%//NP—005465
  • HCHON20000380
  • HCHON20001560//TRANSCRIPTION FACTOR-LIKE PROTEIN MORF4.//7.20E-116//235aa//93%//Q9Y690
  • HCHON20002260
  • HCHON20003220//10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.6) (10-FTHFDH) (FBP-CI).//2.30E-302//731aa//72%//P28037
  • HCHON20003440//Homo sapiens cyclin-D binding Myb-like protein mRNA, complete cds.//1.30E-64//155aa//87%//AF084530
  • HCHON20007380//Homo sapiens mRNA for HELG protein.//3.90E-129//331aa//76%//AJ277291
  • HCHON20007510//rab6 GTPase activating protein (GAP and centrosome-associated)//O//765aa//62%//NP—036329
  • HCHON20008150
  • HCHON20008180
  • HCHON20008320//ZINC FINGER PROTEIN 135.//2.20E-130//345aa//62%//P52742
  • HCHON20008980
  • HCHON20009350
  • HCHON20009560//ZINC FINGER PROTEIN 74.//1.50E-22//113aa//46%//Q16587
  • HCHON20010990
  • HCHON20011160
  • HCHON20014970
  • HCHON20015230//Homo sapiens nuclear pore-associated protein (NPAP60L) mRNA, complete cds.//1.40E-78//158aa//97%//AF107840
  • HCHON20015350//PUTATIVE RRNA METHYLTRANSFERASE SPB1 (EC 2.1.1.-).//1.90E-117//771aa//36%//P25582
  • HCHON20015980//Homo sapiens integrin alpha 11 subunit precursor (ITGA11) mRNA, complete cds.//1.00E-227//419aa//99%//AF137378
  • HCHON20016040//INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 PRECURSOR (IGFBP-3) (IBP-3) (IGF-BINDING PROTEIN 3).//2.00E-21//45aa//97%//P17936
  • HCHON20016650//Mus musculus seven-pass transmembrane receptor precursor (Celsr1) mRNA, complete cds.//6.20E-27//343aa//27%//AF031572
  • HCHON20022470
  • HCHON20035130//ZINC FINGER PROTEIN 22 (ZINC FINGER PROTEIN KOX15) (FRAGMENT).//1.10E-18//64aa//56%//P17026
  • HCHON20036420//Homo sapiens mRNA for PED phosphoprotein.//1.30E-64//130aa//100%//Y13736
  • HCHON20036760
  • HCHON20040020//TNF-INDUCIBLE PROTEIN CG12—1.//8.80E-40//302aa//36%//095236
  • HCHON20043590
  • HCHON20059870//Hypothetical protein.//4.20E-204//667aa//56%//AL163279
  • HCHON20064590//ALPHA-2-MACROGLOBULIN PRECURSOR (ALPHA-2-M).//5.00E-38//654aa//27%//P01023
  • HCHON20067220
  • HCHON20067700//Homo sapiens gremlin mRNA, complete cds.//5.70E-76//106aa//99%//AF045800
  • HCHON20068410//Drosophila melanogaster microtubule associated protein (asp) mRNA, complete cds.//8.10E-47//803aa//27%//U95171
  • HCHON20068710
  • HCHON20074820
  • HCHON20076500
  • HCHON20086720//INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 PRECURSOR (IGFBP-3) (IBP-3) (IGF-BINDING PROTEIN 3).//4.10E-113//205aa//100%//P17936
  • HCHON20097490//dedicator of cyto-kinesis 1//1.00E-154//860aa//37%//NP—001371
  • HCHON20100740//LACTADHERIN PRECURSOR (MILK FAT GLOBULE-EGF FACTOR 8) (MFG-E8) (HMFG) (BREAST EPITHELIAL ANTIGEN BA46) (MFGM) [CONTAINS: MEDIN].//1.60E-205//363aa//99%//Q08431
  • HEART20003060//BASIGIN PRECURSOR (LEUKOCYTE ACTIVATION ANTIGEN M6) (COLLAGENASE STIMULATORY FACTOR) (EXTRACELLULAR MATRIX METALLOPROTEINASE INDUCER) (EMMPRIN) (5F7) (CD147 ANTIGEN).//1.30E-132//248aa//100%//P35613
  • HEART20005410
  • HEART20017730//ANKYRIN 2 (BRAIN ANKYRIN) (ANKYRIN B) (ANKYRIN, NONERYTHROID).//2.40E-25//368aa//30%//Q01484
  • HEART20021840
  • HEART20025980//Homo sapiens smoothelin large isoform L2 (SMTN) mRNA, complete cds.//9.00E-152//223aa//97%//AF064238
  • HEART20034320//ENDOGLUCANASE Z PRECURSOR (EC 3.2.1.4) (ENDO-1,4-BETA-GLUCANASE) (THERMOACTIVE CELLULASE) (AVICELASE I).//1.20E-64//480aa//32%//P23659
  • HEART20037810
  • HEART20049400
  • HEART20049410//Homo sapiens cerberus-related protein (CER1) gene, complete cds.//1.10E-12//144aa//29%//AF090189
  • HEART20049800
  • HEART20061950//Homo sapiens mRNA for myopodin.//1.30E-28//327aa//35%//AJ010482
  • HEART20063340
  • HEART20067870
  • HEART20067890
  • HEART20072310
  • HEART20074430
  • HEART20077670//Mus musculus mRNA for E-MAP-115 protein.//1.70E-50//363aa//41%//Y15197
  • HEART20083640//Mus musculus Xin mRNA, complete cds.//3.10E-63//272aa//58%//AF051945
  • HEART20089940
  • HEART20090000//Rattus norvegicus PIPP mRNA for proline-rich inositol polyphosphate 5-phosphatase, complete cds.//0//639aa//91%//AB032551
  • HEART20095990
  • HHDPC10000650
  • HHDPC10000830//HYPOTHETICAL 24.9 KDA PROTEIN C16C10.7 IN CHROMOSOME III.//1.50E-23//56aa//60%//Q09463
  • HHDPC20001040
  • HHDPC20006920
  • HHDPC20014320//ADAM 12 PRECURSOR (EC 3.4.24.-) (A DISINTEGRIN AND METALLOPROTEINASE DOMAIN 12) (MELTRIN ALPHA).//1.20E-14//139aa//38%//043184
  • HHDPC20030490//LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR (LPS-INDUCED TNF-ALPHA FACTOR) (P53-INDUCED PROTEIN 7).//1.90E-69//134aa//95%//Q99732
  • HHDPC20031130//Kruppel-type zinc finger (C2H2) [Homo sapiens]//3.30E-196//607aa//57%//NP—005806
  • HHDPC20034390
  • HHDPC20034720//CHLORIDE INTRACELLULAR CHANNEL PROTEIN 4 (INTRACELLULAR CHLORIDE ION CHANNEL PROTEIN P64H1).//1.50E-121//213aa//99%//Q9Y696
  • HHDPC20057420//Mus musculus proline-rich protein (Bprp) mRNA, complete cds.//5.40E-45//143aa//69%//AF085348
  • HHDPC20057940
  • HHDPC20064600//SUPPRESSOR PROTEIN SRP40.//8.00E-05//175aa//24%//P32583
  • HHDPC20068620//Ig kappa chain precursor V region (0-81VL)-human (fragment)//8.10E-06//132aa//31%//S22658
  • HHDPC20084140//Homo sapiens polyadenylate binding protein-interacting protein-1 (PAIP1) mRNA, complete cds.//8.10E-12//230aa//23%//AF013758
  • HHDPC20091140//Homo sapiens gremlin mRNA, complete cds.//2.20E-60//105aa//100%//AF045800
  • HHDPC20091780//coagulation factor V (proaccelerin, labile factor)//2.00E-26//170aa//40%//NP—000121
  • HHDPC20092080//INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 PRECURSOR (IGFBP-3) (IBP-3) (IGF-BINDING PROTEIN 3).//3.30E-100//185aa//94%//P17936
  • HHDPC20095280
  • HLUNG10000550
  • HLUNG20016330//Homo sapiens actin filament associated protein (AFAP) mRNA, complete cds.//6.70E-130//531aa//49%//AF188700
  • HLUNG20016770
  • HLUNG20017120//PEPTIDE CHAIN RELEASE FACTOR 2 (RF-2).//8.40E-11//82aa//40%//Q53915
  • HLUNG20023340//Mus musculus SLM-1 (Slm1) mRNA, complete cds.//8.80E-141//270aa//95%//AF098796
  • HLUNG20033780//Rho guanine nucleotide exchange factor 5//6.00E-60//440aa//38%//NP—005426
  • HLUNG20084390
  • IMR3220002430//CHROMATIN ASSEMBLY FACTOR 1 P48 SUBUNIT (CAF-1 P48 SUBUNIT) (RETINOBLASTOMA BINDING PROTEIN P48) (RETINOBLASTOMA-BINDING PROTEIN 4) (MSI1 PROTEIN HOMOLOG).//7.10E-09//303aa//24%//Q09028
  • KIDNE20002520//glutamyl tRNA synthetase homolog//9.90E-156//290aa//100%//T00743
  • KIDNE20003940//RENAL SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2 (SODIUM/PHOSPHATE COTRANSPORTER 2) (NA(+)/PI COTRANSPORTER 2) (RENAL SODIUM-PHOSPHATE TRANSPORT PROTEIN 2) (RENAL NA+-DEPENDENT PHOSPHATE COTRANSPORTER 2).//1.80E-151//582aa//51%//Q06496
  • KIDNE20006780
  • KIDNE20007210//Xenopus laevis mRNA for RPA interacting protein alpha (ripalpha gene).//8.30E-17//104aa//47%//AJ243177
  • KIDNE20007770//CARCINOEMBRYONIC ANTIGEN CGM6 PRECURSOR(NONSPECIFIC CROSS-REACTING ANTIGEN NCA-95) (ANTIGEN CD67) (CD66B ANTIGEN).//1.20E-17//326aa//27%//P31997
  • KIDNE20008010//Homo sapiens mRNA for putative protein kinase (WNK1 gene).//2.50E-25//460aa//29%//AJ296290
  • KIDNE20009470
  • KIDNE20011170
  • KIDNE20011400
  • KIDNE20013730
  • KIDNE20017130//Oreochromis niloticus sex-determining protein DMO mRNA, complete cds.//5.10E-43//252aa//43%//AF203490
  • KIDNE20018730
  • KIDNE20018970
  • KIDNE20020150//HEAT SHOCK 70 KDA PROTEIN 1 (HSP70.1) (HSP70-1/HSP70-2).//9.90E-251//458aa//98%//P08107
  • KIDNE20021680//SHORT CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE PRECURSOR (EC 1.1.1.35) (HCDH).//7.10E-141//273aa//98%//Q16836
  • KIDNE20021910//Homo sapiens MRS1 mRNA, complete cds.//2.30E-30//339aa//27%//AF093239
  • KIDNE20021980
  • KIDNE20022620//like-glycosyltransferase//8.50E-253//633aa//70%//NP—004728
  • KIDNE20024830//Homo sapiens copine I mRNA, complete cds.//1.30E-46//134aa//47%//U83246
  • KIDNE20027250//ZINC FINGER PROTEIN 41 (ZFP-41) (CTFIN92) (FRAGMENT).//3.80E-55//105aa//91%//Q02526
  • KIDNE20027950//ZINC FINGER PROTEIN 7 (ZINC FINGER PROTEIN KOX4) (ZINC FINGER PROTEIN HF.16).//2.40E-40//82aa//100%//P17097
  • KIDNE20028390//GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE (EC 2.7.7.10).//6.00E-70//85aa//90%//P43424
  • KIDNE20028720//Mus musculus Ac39/physophilin mRNA, complete cds.//2.70E-130//345aa//68%//U21549
  • KIDNE20028830
  • KIDNE20029800
  • KIDNE20067330
  • KIDNE20079440
  • KIDNE20096280
  • KIDNE20096470
  • KIDNE20100070//Rattus norvegicus kidney-specific protein (KS) mRNA, complete cds.//1.20E-253//572aa//77%//AF062389
  • KIDNE20100840
  • KIDNE20101370//GOLGIN-95.//3.40E-20//76aa//68%//Q08379
  • KIDNE20101510//UROMODULIN PRECURSOR (TAMM-HORSFALL URINARY GLYCOPROTEIN) (THP).//0//519aa//95%//P07911
  • KIDNE20102650
  • KIDNE20102710//Mus musculus mRNA for Shank3b protein (shank3 gene).//1.20E-81//203aa//71%//AJ245904
  • KIDNE20104300
  • KIDNE20106740
  • KIDNE20107390//Homo sapiens CHRAC17 (CHRAC17) mRNA, complete cds.//1.50E-40//105aa//86%//AF226077
  • KIDNE20107500
  • KIDNE20107620//Rattus norvegicus protein kinase WNK1 (WNK1) mRNA, complete cds.//8.70E-140//266aa//74%//AF227741
  • KIDNE20109730//Mus musculus orphan transporter isoform B9 (Xtrp2) mRNA, alternatively spliced, complete cds.//8.70E-34//103aa//65%//AF075266
  • KIDNE20109890//Rattus norvegicus TGF-beta resistance-associated protein (TRAG) mRNA, complete cds.//2.60E-141//774aa//37%//AF305813
  • KIDNE20112000
  • KIDNE20115080//Homo sapiens mRNA for hNBL4, complete cds.//6.20E-115//226aa//96%//AB030240
  • KIDNE20118580//actin interacting protein [Arabidopsis thaliana].//5.00E-34//140aa//56%//CAB16815
  • KIDNE20120090
  • KIDNE20121880//Mus musculus claudin-19 mRNA, partial cds.//6.10E-97//193aa//95%//AF249889
  • KIDNE20122910
  • KIDNE20124400//Homo sapiens mRNA for ALEX1, complete cds.//1.10E-18//167aa//28%//AB039670
  • KIDNE20125630
  • KIDNE20126010
  • KIDNE20126130
  • KIDNE20127100//Drosophila melanogaster Diablo (dbo) mRNA, complete cds.//1.10E-10//254aa//26%//AF237711
  • KIDNE20127450
  • KIDNE20127750//Homo sapiens partial mRNA for transport-secretion protein 2.1 (TTS-2.1 gene).//6.50E-45//178aa//46%//AJ278475
  • KIDNE20130450
  • KIDNE20131580//Homo sapiens mRNA for LAK-4p, complete cds.//1.80E-111//211aa//100%//AB002405
  • KIDNE20132180
  • KIDNE20137340//HYPOTHETICAL 49.1 KDA PROTEIN C11D3.06 IN CHROMOSOME I.//5.80E-13//149aa//30%//Q10085
  • KIDNE20138010
  • KIDNE20141190
  • KIDNE20144890
  • KIDNE20148900
  • KIDNE20163880
  • KIDNE20180710
  • KIDNE20181660
  • KIDNE20182690//Homo sapiens mRNA for RERE, complete cds.//3.50E-222//401aa//99%//AB036737
  • KIDNE20186780
  • KIDNE20190740//Rattus norvegicus SNIP-b mRNA, complete cds.//6.70E-20//51aa//92%//AF156982
  • LIVER10001260
  • LIVER10004790
  • LIVER20002160//HEAT SHOCK COGNATE 71 KDA PROTEIN.//0//585aa//95%//P11142
  • LIVER20011130//Homo sapiens F-box protein FBL9 mRNA, partial cds.//5.50E-107//210aa//99%//AF176701
  • LIVER20011910
  • LIVER20028420
  • LIVER20035110
  • LIVER20035680
  • LIVER20038540
  • LIVER20045650
  • LIVER20055200//Homo sapiens leucocyte immunoglobulin-like receptor-8 (LIR-8) mRNA, complete cds.//2.50E-43//132aa//71%//AF025534
  • LIVER20055440//Homo sapiens Rho GAP p190-A mRNA, complete cds.//2.90E-101//195aa//98%//AF159851
  • LIVER20059810//UDP-GLUCOSE 4-EPIMERASE (EC 5.1.3.2) (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE).//1.60E-15//39aa//100%//Q14376
  • LIVER20062510
  • LIVER20064100//Ciona intestinalis mRNA for myoplasmin-C1, complete cds.//2.90E-14//167aa//26%//D42167
  • LIVER20064690//PLASMA SERINE PROTEASE INHIBITOR PRECURSOR (PCI) (PROTEIN C INHIBITOR) (PLASMINOGEN ACTIVATOR INHIBITOR-3) (PAI3).//1.70E-146//319aa//89%//P05154
  • LIVER20075680
  • LIVER20080530//Drosophila melanogaster forked mRNA for large Forked protein, complete cds.//1.10E-11//198aa//32%//D21203
  • LIVER20084730
  • LIVER20085800
  • LIVER20087060//Mus musculus putative purine nucleotide binding protein mRNA, complete cds.//2.70E-233//619aa//70%//U44731
  • LIVER20087510
  • LIVER20091180
  • MAMGL10000830//Drosophila melanogaster L82B (L82) mRNA, complete cds.//3.00E-27//231aa//38%//AF125385
  • MESAN10001260//Drosophila melanogaster Crossveinless 2 (CV-2) mRNA, complete cds.//6.50E-104//628aa//35%//AF288223
  • MESAN20004570//MEDIAN BODY PROTEIN.//3.00E-07//343aa//23%//Q08014
  • MESAN20014500//Drosophila melanogaster Dispatched (dispatched) mRNA, complete cds.//1.60E-46//225aa//37%//AF200691
  • MESAN20025190//Mus musculus cell cycle checkpoint control protein Mrad9 gene, complete cds.//7.30E-19//43aa//97%//AF045662
  • MESAN20027090
  • MESAN20029400
  • MESAN20031900//Homo sapiens mRNA for zinc-binding protein (Rbcc728 gene).//2.90E-161//724aa//43%//AJ272269
  • MESAN20035290
  • MESAN20036460
  • MESAN20038510
  • MESAN20089360
  • MESAN20101140//PINCH PROTEIN (PARTICULARY INTERESTING NEW CYS-HIS PROTEIN).//2.30E-25//52aa//98%//P48059
  • MESAN20103120//Homo sapiens sodium/calcium exchanger NCKX3 (SLC24A3) mRNA, complete cds.//4.10E-66//289aa//37%//AF169257
  • MESAN20106640
  • MESAN20115970
  • MESAN20121130
  • MESAN20125860//MELANOTRANSFERRIN PRECURSOR (MELANOMA-ASSOCIATED ANTIGEN P97).//1.30E-40//81aa//100%//P08582
  • MESAN20127350//myelin expression factor-3//2.80E-15//227aa//29%//JE0163
  • MESAN20130220//Homo sapiens testis-specific chromodomain Y-like protein (CDYL) mRNA, alternatively processed, complete cds.//2.10E-126//319aa//63%//AF081258
  • MESAN20132110
  • MESAN20136110//Ciona savignyi mRNA for PEM-3, complete cds.//1.90E-85//236aa//65%//AB001769
  • MESAN20138450
  • MESAN20139360
  • MESAN20141920//Human ovarian cancer downregulated myosin heavy chain homolog (Doc1) mRNA, complete cds.//0//691aa//97%//U53445
  • MESAN20152770
  • MESAN20153910
  • MESAN20154010//Homo sapiens mRNA for putative ribulose-5-phosphate-epimerase, partial cds.//9.10E-60//69aa//100%//AJ224326
  • MESAN20157080
  • MESAN20161590
  • MESAN20164090
  • MESAN20171520//Homo sapiens TNF intracellular domain-interacting protein mRNA, complete cds.//9.30E-30//198aa//40%//AF168676
  • MESAN20174170//REGULATOR OF G-PROTEIN SIGNALING 4 (RGS4) (RGP4).//1.80E-39//80aa//98%//P49798
  • MESAN20182090
  • MESAN20186700
  • NESOP10001080
  • NOVAR10000150
  • NOVAR10000910//COLORECTAL MUTANT CANCER PROTEIN (MCC PROTEIN).//6.00E-199//392aa//98%//P23508
  • NOVAR10001020
  • NOVAR20000380
  • NOVAR20003520
  • NT2NE20003740
  • NT2NE20010050
  • NT2NE20010210
  • NT2NE20010400//Homo sapiens GLO13 mRNA, complete cds.//2.90E-51//223aa//60%//AF267859
  • NT2NE20010490//ZINC FINGER PROTEIN 85 (ZINC FINGER PROTEIN HPF4) (HTF1).//1.30E-194//464aa//72%//Q03923
  • NT2NE20015240
  • NT2NE20021620//Saccharomyces cerevisiae Vps9p (VPS9) gene, complete cds.//1.00E-13//250aa//24%//U20373
  • NT2NE20043780
  • NT2NE20053580
  • NT2NE20068130//CELL SURFACE GLYCOPROTEIN 1 PRECURSOR (OUTER LAYER PROTEIN B) (S-LAYER PROTEIN 1).//2.50E-34//377aa//40%//Q06852
  • NT2NE20072200
  • NT2NE20074250
  • NT2NE20080170//HUNTINGTIN-ASSOCIATED PROTEIN-INTERACTING PROTEIN (DUO PROTEIN) (KALIRIN) (PAM COOH-TERMINAL INTERACTOR PROTEIN 10) (P-CIP10).//6.60E-57//661aa//27%//P97924
  • NT2NE20089610
  • NT2NE20089970//ZINC FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10) (HPF7).//1.60E-29//77aa//81%//Q05481
  • NT2NE20108540
  • NT2NE20110360
  • NT2NE20118960//DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE-PROTEIN GLYCOSYLTRANSFERASE 63 KDA SUBUNIT PRECURSOR (EC 2.4.1.119) (RIBOPHORIN II).//9.30E-274//562aa//94%//P04844
  • NT2NE20122430//GLYOXYLATE-INDUCED PROTEIN.//7.70E-25//144aa//38%//P30147
  • NT2NE20124480
  • NT2NE20125050//Gallus gallus mRNA for avena, complete cds.//5.80E-199//468aa//84%//AB017437
  • NT2NE20130190
  • NT2NE20131890
  • NT2NE20132170//Rattus norvegicus lysosomal amino acid transporter 1 mRNA, complete cds.//3.70E-97//357aa//52%//AF361239
  • NT2NE20142210//SINGLE-MINDED HOMOLOG 2 (SIM TRANSCRIPTION FACTOR) (MSIM).//3.00E-24//660aa//26%//Q61079
  • NT2NE20146810
  • NT2NE20152750
  • NT2NE20155110
  • NT2NE20156260
  • NT2NE20157470//COMPLEMENT C2 PRECURSOR (EC 3.4.21.43) (C3/C5 CONVERTASE).//6.60E-138//256aa//100%//P06681
  • NT2NE20158600//erythroid ankyrin-Synechocystis sp. (strain PCC 6803).//7.00E-13//160aa//31%//S74626
  • NT2NE20159740
  • NT2NE20172590
  • NT2NE20174800
  • NT2NE20174920
  • NT2NE20177520//Guinea pig mRNA for decay-accelerating factor (isoform GDab-SEC), complete cds.//1.70E-15//273aa//28%//D49421
  • NT2NE20181650//Shb=Src homology 2 protein//2.90E-36//115aa//43%//AAB29780
  • NT2NE20183760
  • NT2NE20184900//Mus musculus mRNA for transcription factor CA150b, complete cds.//8.60E-29//98aa//55%//AB023485
  • NT2NE20187390
  • NT2RI20001330//Homo sapiens KE03 protein mRNA, partial cds.//3.40E-103//339aa//57%//AF064604
  • NT2RI20003480//GLYPICAN-2 PRECURSOR (CEREBROGLYCAN) (HSPG M13).//1.80E-261//581aa//82%//P51653
  • NT2RI20005750//Rattus norvegicus GTP-binding protein REM2 (Rem2) mRNA, complete cds.//8.90E-139//272aa//95%//AF084464
  • NT2RI20009870//lunatic fringe precursor [Mus musculus]//5.50E-123//237aa//91%//U94351
  • NT2RI20022600
  • NT2RI20023160
  • NT2RI20023590
  • NT2RI20023910//Homo sapiens TMTSP mRNA for transmembrane molecule with thrombospondin module, complete cds.//0//480aa//96%//AB044385
  • NT2RI20025400//Mouse mRNA for P24 protein, complete cds.//9.70E-94//196aa//91%//D83206
  • NT2RI20025640
  • NT2RI20028470
  • NT2RI20036670
  • NT2RI20040930//MITOCHONDRIAL CARRIER PROTEIN YMC2 PRECURSOR.//1.10E-27//194aa//38%//P38087
  • NT2RI20040990//ANKYRIN 2 (BRAIN ANKYRIN) (ANKYRIN B) (ANKYRIN, NONERYTHROID).//2.40E-25//368aa//30%//Q01484
  • NT2RI20041880//MYOSIN HEAVY CHAIN, NONMUSCLE TYPE A (CELLULAR MYOSIN HEAVY CHAIN, TYPE A) (NMMHC-A).//8.10E-10//322aa//21%//P35579
  • NT2RI20046080
  • NT2RI20048840//GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-2 SUBUNIT (ADENYLATE CYCLASE-INHIBITING G ALPHA PROTEIN).//2.10E-171//316aa//100%//P04899
  • NT2RI20050960//Homo sapiens p53 regulated PA26-T2 nuclear protein (PA26) mRNA, complete cds.//5.40E-164//496aa//61%//AF033120
  • NT2RI20054050//Drosophila melanogaster Abnormal X segregation (Axs) gene, complete cds.//2.40E-83//487aa//37%//AF101361
  • NT2RI20055790
  • NT2RI20056700//NEURONAL OLFACTOMEDIN-RELATED ER LOCALIZED PROTEIN PRECURSOR (NOEL) (1B426B).//3.40E-237//439aa//97%//Q62609
  • NT2RI20069730
  • NT2RI20076290
  • NT2RI20086220
  • NT2RI20091730
  • NT2RI20091940//CORNICHON-LIKE PROTEIN.//9.70E-73//159aa//81%//035089
  • NT2RI20198260
  • NT2R1 20203900
  • NT2RI20207030
  • NT2RI20216250
  • NT2RI20240080//SMALL GLUTAMINE-RICH TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN.//1.30E-86//311aa//58%//043765
  • NT2R120244600//Homo sapiens mRNA for sphingosine-1-phosphatase (ORF1).//2.60E-50//273aa//36%//AJ293294
  • NT2RI20244960
  • NT2RI20250750
  • NT2RI20252550
  • NT2RI20273230//PUTATIVE HELICASE YGR271W.//1.10E-14//152aa//38%//P53327
  • NT2RP60000770//Homo sapiens mRNA for ZAC zinc finger protein.//5.80E-179//325aa//98%//AJ006354
  • NT2RP60000850//Bos taurus RPGR-interacting protein-1 (RPGRIP1) mRNA, complete cds.//2.10E-139//751aa//38%//AF227258
  • NT2RP70010740
  • NT2RP70027380//N-CHIMAERIN (NC) (N-CHIMERIN) (ALPHA CHIMERIN) (A-CHIMAERIN).//7.40E-31//203aa//36%//P15882
  • NT2RP70032610//ALPHA ENOLASE (EC 4.2.1.11) (2-PHOSPHO-D-GLYCERATE HYDRO-LYASE) (NON-NEURAL ENOLASE) (NNE) (PHOSPHOPYRUVATE HYDRATASE).//4.40E-180//387aa//88%//P06733
  • NT2RP70036880//Gtpase activating protein for Ypt1p; Gyp1p [Saccharomyce scerevisiae].//2.00E-66//250aa//50%//NP—014713
  • NT2RP70037240//H. sapiens E-MAP-115 mRNA.//1.10E-79//475aa//41%//X73882
  • NT2RP70043480//ZINC FINGER PROTEIN 93 (ZINC FINGER PROTEIN HTF34) (FRAGMENT).//0//588aa//91%//P35789
  • NT2RP70044280//CTD-BINDING SR-LIKE PROTEIN RA4 (FRAGMENT).//1.20E-11//190aa//31%//095104
  • NT2RP70045590//PUTATIVE ENDONUCLEASE C1F12.06C (EC 3.1.-.-).//3.60E-34//246aa//36%//Q10348
  • NT2RP70056750
  • NT2RP70062230//NEUROFILAMENT TRIPLET H PROTEIN (200 KDA NEUROFILAMENT PROTEIN) (NF-H).//2.50E-29//622aa//29%//P19246
  • NT2RP70063950//PUTATIVE RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR(RHO/RAC GEF) (FACIOGENITAL DYSPLASIA PROTEIN HOMOLOG).//4.90E-13//417aa//26%//P52734
  • NT2RP70072690
  • NT2RP70075240
  • NT2RP70077660
  • NT2RP70078420//Drosophila melanogaster Centaurin Gamma 1A (ceng1A) mRNA, complete cds.//1.00E-120//700aa//40%//AF254741
  • NT2RP70080850
  • NT2RP70081610//Mus musculus 101F6 protein mRNA, complete cds.//5.20E-52//214aa//50%//AF131206
  • NT2RP70085440
  • NT2RP70102350//Mus musculus mRNA for Olig3 bHLH protein, complete cds.//1.90E-134//257aa//98%//AB038698
  • NT2RP70105210
  • NT2RP70110860
  • NT2RP70111320
  • NT2RP70122910
  • NT2RP70125160
  • NT2RP70130020
  • NT2RP70133740//SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 2.//2.60E-136//267aa//94%//015127
  • NT2RP70134990
  • NT2RP70137290
  • NT2RP70137640
  • NT2RP70143480
  • NT2RP70147210
  • NT2RP70150800
  • NT2RP70157890//zinc finger protein 267; zinc finger (C2H2) [Homo sapiens]//1.60E-125//228aa//99%//NP—003405
  • NT2RP70159960//Rattus norvegicus p135 SynGAP mRNA, partial cds.//4.80E-60//177aa//69%//AF053938
  • NT2RP70169110
  • NT2RP70175670
  • NT2RP70179710
  • NT2RP70181970
  • NT2RP70188020
  • NT2RP70188710
  • NT2RP70190640
  • NT2RP70192730//LYSOSOMAL ACID LIPASE/CHOLESTERYL ESTER HYDROLASE PRECURSOR (EC 3.1.1.13) (LAL) (ACID CHOLESTERYL ESTER HYDROLASE) (STEROL ESTERASE) (LIPASE A) (CHOLESTERYL ESTERASE).//3.00E-181//323aa//99%//P38571
  • NT2RP70194450
  • NT2RP70195430//PUTATIVE NADP-DEPENDENT OXIDOREDUCTASE IN TEHB-RHSE INTERGENIC REGION (EC 1.-.-.-).//1.10E-57//349aa//38%//P76113
  • NT2RP70198350//HEPATOMA-DERIVED GROWTH FACTOR (HDGF).//2.60E-111//213aa//98%//P51858
  • NT2RP70203790
  • NTONG20009770//NEUROLYSIN PRECURSOR (EC 3.4.24.16) (NEUROTENSIN ENDOPEPTIDASE) (MITOCHONDRIAL OLIGOPEPTIDASE M) (MICROSOMAL ENDOPEPTIDASE) (MEP).//1.30E-304//599aa//92%//P42675
  • NTONG20013620//Homo sapiens hydroxysteroid sulfotransferase SULT2B1b (HSST2) mRNA, complete cds.//9.10E-82//151aa//100%//U92315
  • NTONG20015870//KERATIN, TYPE II CYTOSKELETAL 4 (CYTOKERATIN 4) (K4) (CK4).//3.30E-132//489aa//54%//P19013
  • NTONG20028070//CYR61 PROTEIN PRECURSOR (GIG1 PROTEIN) (INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 10).//1.60E-65//133aa//92%//000622
  • NTONG20029480//Mus musculus Xin mRNA, complete cds.//7.20E-93//409aa//54%//AF051945
  • NTONG20029700//Homo sapiens laminin alpha 3b chain mRNA, partial cds.//6.60E-230//425aa//92%//AF005258
  • NTONG20046140//Homo sapiens mRNA for. MNK1, complete cds.//5.70E-89//177aa//98%//AB000409
  • NTONG20048060
  • NTONG20049910
  • NTONG20050620
  • NTONG20050860
  • NTONG20051530//KUPFFER CELL RECEPTOR.//6.30E-85//391aa//45%//P70194
  • NTONG20052650//Gallus gallus Xin mRNA, complete cds.//5.40E-146//768aa//40%//AF051944
  • NTONG20056570//CORONIN-LIKE PROTEIN P57.//2.20E-121//356aa//62%//Q92176
  • NTONG20061870
  • NTONG20063010//Mus musculus EF-9 mRNA, partial cds.//1.70E-78//154aa//92%//U72678
  • NTONG20064400//REPETIN.//2.20E-107//446aa//50%//P97347
  • NTONG20064840//Mus musculus slp1 mRNA for synaptotagmin-like protein 1, complete cds.//2.60E-128//258aa//90%//AB050741
  • NTONG20065010
  • NTONG20066460//Mus musculus Gd mRNA for gasdermin, complete cds.//8.30E-207//446aa//88%//AB033595
  • NTONG20067090//Mus musculus mRNA for Sh3y11, complete cds.//2.00E-63//136aa//91%//D85926
  • NTONG20067830//ANKYRIN 1 (ERYTHROCYTE ANKYRIN) (ANKYRIN R) (ANKYRINS 2.1 AND 2.2).//1.10E-24//227aa//34%//P16157
  • NTONG20070200//ZINC FINGER PROTEIN 83 (ZINC FINGER PROTEIN HPF1).//1.30E-134//352aa//65%//P51522
  • NTONG20070340//collagen alpha 1(IX) chain//1.50E-43//220aa//45%//S42617
  • NTONG20075220//Rattus norvegicus SNIP-a mRNA, complete cds.//1.80E-121//436aa//41%//AF156981
  • NTONG20076930//ALPHA-1-INHIBITOR III PRECURSOR.//1.20E-124//513aa//47%//P14046
  • NTONG20077560
  • NTONG20083650
  • NTONG20088620//Homo sapiens genethonin 3 mRNA, partial cds.//4.90E-202//390aa//99%//AF177292
  • NTONG20090600//SYNAPSIN I (BRAIN PROTEIN 4.1).//2.10E-07//198aa//29%//P17600
  • NTONG20090680
  • NTONG20092290
  • NTONG20092330//BESTROPHIN (VITELLIFORM MACULAR DYSTROPHY PROTEIN) (TU15B).//1.40E-135//414aa//59%//076090
  • OCBBF10000540//Mus musculus rjs (rjs) mRNA, complete cds.//4.00E-14//105aa//36%//AF061529
  • OCBBF10001750//Mus musculus mRNA for sprouty-4, complete cds.//1.50E-159//300aa//92%//AB019280
  • OCBBF10001850//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//8.90E-166//605aa//51%//P51523
  • OCBBF20005230
  • OCBBF20006770//TREACLE PROTEIN (TREACHER COLLINS SYNDROME PROTEIN).//2.50E-287//693aa//84%//Q13428
  • OCBBF20013890
  • OCBBF20019380//seizure related gene 6//6.00E-170//336aa//90%//NP—067261
  • OCBBF20019830
  • OCBBF20020150
  • OCBBF20020830//Homo sapiens Pumilio 1 (PUMH1) mRNA, complete cds.//0//814aa//99%//AF315592
  • OCBBF20022900//Homo sapiens SCHIP-1 mRNA, complete cds.//2.80E-250//469aa//99%//AF145713
  • OCBBF20023570
  • OCBBF20026630
  • OCBBF20028050//Homo sapiens B2 gene partial cDNA, clone B2E.//7.70E-38//246aa//33%//AJ002220
  • OCBBF20028650//DOSAGE COMPENSATION REGULATOR (MALE-LESS PROTEIN) (NO ACTION POTENTIAL PROTEIN).//1.40E-50//160aa//47%//P24785
  • OCBBF20029800
  • OCBBF20030280//Rattus norvegicus hfb2 mRNA, complete cds.//5.20E-63//175aa//68%//AF031483
  • OCBBF20030910//PUROMYCIN-SENSITIVE AMINOPEPTIDASE (EC 3.4.11.-) (PSA).//2.90E-146//279aa//98%//P55786
  • OCBBF20032460
  • OCBBF20035930//BETA-SOLUBLE NSF ATTACHMENT PROTEIN (SNAP-BETA).//7.80E-135//264aa//96%//P81126
  • OCBBF20037440//ZINC-FINGER PROTEIN HT2A (72 KDA TAT-INTERACTING PROTEIN).//2.10E-08//80aa//40%//Q13049
  • OCBBF20039250//Homo sapiens breast cancer metastasis-suppressor 1 (BRMS1) mRNA, complete cds.//2.20E-55//188aa//56%//AF159141
  • OCBBF20041680
  • OCBBF20045330
  • OCBBF20046120//zinc finger protein 16 (KOX 9)//1.00E-131//350aa//59%//NP—008889
  • OCBBF20046470//ARFAPTIN 1.//5.80E-114//229aa//97%//P53367
  • OCBBF20046690//PROBABLE CATION-TRANSPORTING ATPASE WO8D2.5 IN CHROMOSOME IV (EC 3.6.1.-).//4.20E-105//249aa//39%//Q27533
  • OCBBF20047570
  • OCBBF20048660
  • OCBBF20049300//ZINC FINGER PROTEIN 184 (FRAGMENT).//7.10E-141//566aa//45%//Q99676
  • OCBBF20049840//Homo sapiens mRNA for neurabin II protein.//4.90E-166//808aa//47%//AJ401189
  • OCBBF20050770//CARNITINE O-PALMITOYLTRANSFERASE I, MITOCHONDRIAL LIVER ISOFORM (EC 2.3.1.21) (CPT I) (CPTI-L).//3.10E-211//653aa//56%//P32198
  • OCBBF20051610
  • OCBBF20053430//Mus musculus MAST205 protein kinase mRNA, complete cds.//0//498aa//94%//U02313
  • OCBBF20053490//MANNOSE-6-PHOSPHATE ISOMERASE (EC 5.3.1.8) (PHOSPHOMANNOSE ISOMERASE) (PMI) (PHOSPHOHEXOMUTASE).//1.10E-24//52aa//100%//P34949
  • OCBBF20053730//85 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 (EC 3.1.1.4) (IPLA2) (CAI-PLA2).//0//636aa//91%//060733
  • OCBBF20054200//DEVELOPMENTAL PROTEIN SEVEN IN ABSENTIA.//1.10E-27//97aa//54%//P21461
  • OCBBF20054760//SERINE/THREONINE PROTEIN KINASE RIP (EC 2.7.1.-) (CELL DEATH PROTEIN RIP) (RECEPTOR INTERACTING PROTEIN).//4.00E-122//230aa//97%//Q13546
  • OCBBF20059560//Homo sapiens (clone D320) C219-reactive peptide mRNA, partial cds.//6.70E-39//140aa//62%//L34688
  • OCBBF20060300
  • OCBBF20061720
  • OCBBF20062140
  • OCBBF20062410
  • OCBBF20063320
  • OCBBF20066390//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//8.90E-63//173aa//65%//P51523
  • OCBBF20068490//Mus musculus RW1 protein mRNA, complete cds.//4.60E-40//310aa//37%//AF060565
  • OCBBF20071210//M-PHASE PHOSPHOPROTEIN 9 (FRAGMENT).//1.80E-96//184aa//100%//Q99550
  • OCBBF20071840//ZINC FINGER PROTEIN 135.//1.00E-139//416aa//57%//P52742
  • OCBBF20071960//Coturnix coturnix japonica qMEF2D gene.//6.50E-06//124aa//31%//AJ002238
  • OCBBF20072240//Homo sapiens candidate tumor suppressor protein DICE1 mRNA, complete cds.//7.60E-165//354aa//83%//AF097645
  • OCBBF20072320
  • OCBBF20073540//Homo sapiens p30 DBC mRNA, complete cds.//4.00E-65//146aa//91%//AF293335
  • OCBBF20074140
  • OCBBF20076220
  • OCBBF20078920//Homo sapiens zinc-finger helicase (hZFH) mRNA,-complete cds.//3.10E-67//152aa//92%//U91543
  • OCBBF20079310
  • OCBBF20079460
  • OCBBF20080050//RTOA PROTEIN (RATIO-A).//3.50E-07//191aa//32%//P54681
  • OCBBF20080410//ZINC FINGER PROTEIN 43 (ZINC PROTEIN HTF6).//6.90E-145//445aa//51%//P28160
  • OCBBF20081380
  • OCBBF20082830//NDRG1 PROTEIN (DIFFERENTIATION-RELATED GENE 1 PROTEIN) (DRG1) (REDUCING AGENTS AND TUNICAMYCIN-RESPONSIVE PROTEIN) (RTP) (NICKEL-SPECIFIC INDUCTION PROTEIN CAP43).//3.10E-190//282aa//99%//Q92597
  • OCBBF20084660
  • OCBBF20085200
  • OCBBF20086400//Mus musculus ADP-ribosylation factor-like membrane-associated protein (Arm1) mRNA, complete cds.//2.10E-114//244aa//87%//AF205936
  • OCBBF20086910//Mus musculus mSox5L mRNA, complete cds.//9.30E-253//528aa//91%//AB006330
  • OCBBF20087010
  • OCBBF20088140
  • OCBBF20088220
  • OCBBF20091150
  • OCBBF20094240
  • OCBBF20097720
  • OCBBF20100400
  • OCBBF20103130
  • OCBBF20104040
  • OCBBF20105570
  • OCBBF20107090//Homo sapiens protocadherin 68 (PCH68) mRNA, complete cds.//2.60E-77//359aa//49%//AF029343
  • OCBBF20107920
  • OCBBF20108190//ZINC FINGER PROTEIN ZFP-36 (FRAGMENT).//2.90E-151//429aa//61%//P16415
  • OCBBF20108430//GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-2 SUBUNIT (ADENYLATE CYCLASE-INHIBITING G ALPHA PROTEIN).//2.10E-171//316aa//100%//P04899
  • OCBBF20108580//APICAL-LIKE PROTEIN (APXL PROTEIN).//1.00E-196//376aa//100%//Q13796
  • OCBBF20108630//ATP-BINDING CASSETTE, SUB-FAMILY A, MEMBER 1 (ATP-BINDING CASSETTE TRANSPORTER 1) (ATP-BINDING CASSETTE 1).//1.00E-63//268aa//46%//P41233
  • OCBBF20109310
  • OCBBF20111770
  • OCBBF20116850//Mus musculus Islr(immunoglobulin superfamily containing leucine-rich repeat) mRNA, complete cds.//2.10E-88//285aa//57%//AB024538
  • OCBBF20118970
  • OCBBF20120390//SODIUM-DEPENDENT PROLINE TRANSPORTER (FRAGMENT).//0//636aa//100%//Q99884
  • OCBBF20121390//RING CANAL PROTEIN (KELCH PROTEIN).//7.80E-28//220aa//31%//Q04652
  • OCBBF20122620
  • OCBBF20124360//Homo sapiens mRNA for Misshapen/NIK-related kinase MINK-1, complete cds.//2.70E-98//185aa//100%//AB035698
  • OCBBF20125530//Mus musculus PRAJA1 (Praja1) mRNA, complete cds.//3.60E-110//281aa//77%//U06944
  • OCBBF20126780
  • OCBBF20127040//Drosophila melanogaster woc gene, exons 1-11.//1.10E-09//284aa//24%//AJ276394
  • OCBBF20127140//GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(T) BETA SUBUNIT 1 (TRANSDUCIN BETA CHAIN 1).//5.50E-63//119aa//100%//P04901
  • OCBBF20127550
  • OCBBF20128120//Mus musculus mmDNAJA4 mRNA for mmDj4, complete cds.//1.20E-205//397aa//93%//AB032401
  • OCBBF20129360//1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1 (EC 3.1.4.11) (PLC-DELTA-1) (PHOSPHOLIPASE C-DELTA-1) (PLC-III).//1.00E-130//461aa//36%//P51178
  • OCBBF20130110
  • OCBBF20130910
  • OCBBF20132850//Homo sapiens brain tumor associated protein NAG14 (NAG14) mRNA, complete cds.//3.80E-24//399aa//27%//AF196976
  • OCBBF20139260
  • OCBBF20140640
  • OCBBF20140890
  • OCBBF20145760//GLYPICAN-1 PRECURSOR.//3.40E-118//222aa//100%//P35052
  • OCBBF20148280//Mus musculus mlt 1 gene, complete cds.//1.70E-151//502aa//63%//AB032418
  • OCBBF20148730//RING CANAL PROTEIN (KELCH PROTEIN).//2.90E-43//509aa//26%//Q04652
  • OCBBF20149280//Mus musculus WAVE-1 mRNA, complete cds.//4.30E-07//210aa//29%//AF290877
  • OCBBF20151150
  • OCBBF20153340//Rattus norvegicus cytosolic sorting protein PACS-1a (PACS-1) mRNA, complete cds.//0//701aa//93%//AF076183
  • OCBBF20153350//G PROTEIN PATHWAY SUPPRESSOR 2 (GPS2 PROTEIN).//1.20E-49//103aa//99%//Q13227
  • OCBBF20155060//CADHERIN-RELATED TUMOR SUPPRESSOR PRECURSOR (FAT PROTEIN).//1.90E-67//307aa//37%//P33450
  • OCBBF20164050
  • OCBBF20164670
  • OCBBF20170690
  • OCBBF20173060
  • OCBBF20173250
  • OCBBF20173980//Homo sapiens RCC1-like G exchanging factor RLG mRNA, complete cds.//3.70E-211//531aa//70%//AF060219
  • OCBBF20178150//Plasmodium falciparum ADA2-like protein gene, partial cds.//2.20E-19//322aa//27%//AF184590
  • OCBBF20178880//1′-CIS RETINOL DEHYDROGENASE (EC 1.1.1.105) (11-CIS RDH).//3.90E-37//101aa//78%//Q92781
  • OCBBF20178990
  • OCBBF20180120//Hbmo sapiens sodium-dependent high-affinity dicarboxylate transporter (NADC3) mRNA, complete cds.//1.50E-272//320aa//89%//AF154121
  • OCBBF20180840
  • OCBBF20186870
  • OCBBF20188730
  • OCBBF20189560 PANCR10000910//ATP-binding cassette, sub-family A member 8//2.00E-17//230aa//30%//NP—009099
  • PEBLM10000240
  • PEBLM10000710//leptin receptor//2.10E-29//69aa//91%//U66496
  • PEBLM20013120//Homo sapiens rhotekin mRNA, partial cds.//4.10E-25//164aa//36%//AF290512
  • PEBLM20024320//zinc resistance protein homolog//3.80E-28//139aa//45%//T27544
  • PEBLM20024550
  • PEBLM20040150
  • PEBLM20042900
  • PEBLM20044520//PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN2 (EC 3.1.13.4) (PAB1P-DEPENDENT POLY(A)-NUCLEASE).//2.40E-54//331aa//39%//P53010
  • PEBLM20052820//PROTEIN PHOSPHATASE 2C HOMOLOG 3 (EC 3.1.3.16) (PP2C-3).//7.60E-09//96aa//36%//Q09173
  • PEBLM20060310
  • PEBLM20060360//ZINC FINGER PROTEIN 33A (ZINC FINGER PROTEIN KOX31) (KIAA0065) (HA0946) (FRAGMENT).//5.10E-12//57aa//56%//Q06730
  • PEBLM20060490//polymerase (RNA) III (DNA directed) (39 kD) [Homo sapiens]//1.50E-72//143aa//100%//NP—006457
  • PEBLM20071880
  • PEBLM20072960
  • PEBLM20074370
  • PEBLM20075980//Mus musculus immunoglobulin scavenger receptor IgSR mRNA, complete cds.//2.30E-69//285aa//52%//AF302046
  • PEBLM20078320//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//2.00E-184//543aa//59%//P51523
  • PEBLM20085760//Homo sapiens mRNA for TOLLIP protein.//1.10E-106//153aa//98%//AJ242972
  • PERIC10000250//DNA TOPOISOMERASE III BETA-1 (EC 5.99.1.2).//1.20E-138//271aa//94%//095985
  • PERIC20002140
  • PERIC20003860
  • PERIC20003870//Mus musculus transcriptional activator alpha-NAC (Naca) gene, complete cds.//1.20E-152//956aa//43%//U48363
  • PERIC20004220
  • PERIC20004780//Rattus norvegicus Jun dimerization protein 1 (jdp-1) gene, complete cds.//2.00E-15//73aa//49%//U53450
  • PLACE50000660//PROTEIN ARGININE N-METHYLTRANSFERASE 1 (EC 2.1.1.-).//1.60E-12//200aa//27%//Q63009
  • PLACE60003480//Rattus norvegicus protein associating with small stress protein PASS1 (Pass1) mRNA, complete cds.//4.60E-119//255aa//82%//AF168362
  • PLACE60004630
  • PLACE60060420//60S RIBOSOMAL PROTEIN L44 (L36A).//1.70E-29//58aa//100%//P09896
  • PLACE60079250//Homo sapiens mRNA for actin binding protein ABP620, complete cds.//0//979aa//61%//AB029290
  • PLACE60086400
  • PLACE60119750
  • PLACE60121080
  • PLACE60136500
  • PLACE60136720
  • PLACE60138830
  • PLACE60153220
  • PLACE60155130
  • PLACE60161600
  • PLACE60169420
  • PLACE60177140//PROSTACYCLIN RECEPTOR (PROSTANOID IP RECEPTOR) (PGI RECEPTOR).//9.90E-135//257aa//99%//P43119
  • PLACE60181070
  • PLACE60187690
  • PLACE60188340
  • PROST10003220//HOMEOBOX PROTEIN HOX-A2.//5.00E-69//139aa//95%//043364
  • PROST10004800
  • PROST20005050
  • PROST20005670
  • PROST20021010
  • PROST20024890
  • PROST20029270
  • PROST20047270
  • PROST20047390//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//5.70E-52//427aa//31%//P51523
  • PROST20050670
  • PROST20052280
  • PROST20057930
  • PROST20059040
  • PROST20066880//Mus musculus zinc finger protein 276 C2H2 type (Zfp276) mRNA, complete cds.//9.80E-101//192aa//94%//AF178935
  • PROST20079500
  • PROST20083600//Bos taurus pyruvate dehydrogenase phosphatase regulatory subunit precursor, mRNA, complete cds.//1.40E-101//243aa//83%//AF026954
  • PROST20087700
  • PROST20097950
  • PROST20100460//Homo sapiens secretory mucin MUC6 (MUC6) mRNA, partial cds.//3.10E-216//421aa//98%//U97698
  • PROST20104000//SPLICEOSOME ASSOCIATED PROTEIN 62 (SAP 62) (SF3A66).//1.40E-20//128aa//39%//Q62203
  • PROST20107820//Human C3f mRNA, complete cds.//9.90E-140//252aa//100%//U72515
  • PROST20111050
  • PROST20112970
  • PROST20114390
  • PROST20116600
  • PROST20120050
  • PROST20120160
  • PROST20121900
  • PROST20123530
  • PROST20127400
  • PROST20127800
  • PROST20130530
  • PROST20132600
  • PROST20133270
  • PROST20144220
  • PROST20146010
  • PROST20149160
  • PROST20149250
  • PROST20151240
  • PROST20152460
  • PROST20153320
  • PROST20159240//Homo sapiens Opa-interacting protein OIP2 mRNA, partial cds.//1.10E-19//46aa//100%//AF025438
  • PROST20161950//Mus musculus RalGDS-like protein 3 mRNA, complete cds.//8.30E-88//205aa//85%//AF237669
  • PROST20164440
  • PROST20166680
  • PROST20168290
  • PROST20169800//CYTOCHROME P450 4F2 (EC 1.14.13.30) (CYPIVF2) (LEUKOTRIENE-B4 OMEGA-HYDROXYLASE) (LEUKOTRIENE-B4 20-MONOOXYGENASE) (CYTOCHROME P450-LTB-OMEGA).//6.30E-188//507aa//66%//P78329
  • PROST20170980
  • PROST20171280//hematopoietic zinc finger//2.00E-70//380aa//50%//NP—038894
  • PROST20175290
  • PROST20176170//Homo sapiens ENIGMA protein mRNA, complete cds.//2.60E-156//270aa//98%//AF265209
  • PROST20178360
  • PROST20185830//NITROGEN REGULATORY PROTEIN AREA.//5.50E-07//141aa//28%//013412
  • PROST20189770//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//5.00E-155//459aa//53%//P51523
  • PROST20191640//Mus musculus UbcM4-interacting protein 4 mRNA, complete cds.//1.50E-91//279aa//57%//AF360998
  • PUAEN10000850
  • PUAEN20003740
  • PUAEN20011880//Mus musculus mRNA for MIWI (piwi), complete cds.//2.70E-190//670aa//51%//AB032604
  • PUAEN20015260//Rattus norvegicus inositol polyphosphate multikinase (Ipmk) mRNA, complete cds.//2.40E-111//246aa//85%//AY014898
  • PUAEN20015860//Mus musculus PDZ-RGS3 protein mRNA, complete cds.//1.50E-205//469aa//82%//AF350047
  • PUAEN20018820//C-ETS-2 PROTEIN.//7.90E-261//469aa//99%//P15036
  • PUAEN20025680
  • PUAEN20027580
  • PUAEN20030180//CARBONIC ANHYDRASE XII PRECURSOR (EC 4.2.1.1) (CARBONATE DEHYDRATASE XII) (CA-XII) (TUMOR ANTIGEN HOM-RCC-3.1.3).//7.60E-148//259aa//95%//043570
  • PUAEN20040670//Mus musculus neuronal protein 4.1 mRNA, complete cds.//0//733aa//93%//AF061283
  • PUAEN20044000
  • PUAEN20045110
  • PUAEN20045250
  • PUAEN20051100//Mus musculus otogelin mRNA, complete cds.//2.60E-89//368aa//43%//U96411
  • PUAEN20052470
  • PUAEN20055020//Homo sapiens goodpasture antigen-binding protein (COL4A3BP) mRNA, complete cds.//0//624aa//1.00%//AF136450
  • PUAEN20078980//faciogenital dysplasia homolog//1.00E-19//200aa//39%//NP—032027
  • PUAEN20081230
  • PUAEN20083140//Homo sapiens SWAP-70 mRNA, complete cds.//2.70E-280//451aa//99%//AF210818
  • PUAEN20085150
  • PUAEN20108240//Drosophila melanogaster ankyrin 2 (Ank2) mRNA, complete cds.//5.00E-22//200aa//35%//AF190635
  • RECTM10001410
  • RECTM20003490
  • RECTM20005100
  • SALGL10001710//Homo sapiens mRNA for C110RF25 gene.//1.80E-88//455aa//41%//AJ300461
  • SKMUS20001980//Mus musculus N-RAP mRNA, complete cds.//1.40E-63//141aa//88%//U76618
  • SKMUS20003610//PUTATIVE MITOCHONDRIAL CARRIER PROTEIN PET8.//7.40E-59//274aa//47%//P38921
  • SKMUS20007010//VESTIGIAL PROTEIN.//2.70E-14//209aa//32%//Q26366
  • SKMUS20007800//PROSTAGLANDIN TRANSPORTER (PGT) (MATRIN F/G).//4.20E-47//274aa//36%//Q00910
  • SKMUS20011640
  • SKMUS20012010
  • SKMUS20016220//Mus musculus N-RAP mRNA, complete cds.//1.80E-85//352aa//47%//U76618
  • SKMUS20018230//Homo sapiens MYPT2 mRNA, complete cds.//8.10E-13//107aa//40%//AB003062
  • SKMUS20018500//Homo sapiens t(3;5)(q25.1;p34) fusion gene NPM-MLF1 mRNA, complete cds.//2.30E-131//268aa//94%//L49054
  • SKMUS20020840
  • SKMUS20021530//Homo sapiens SPG protein (SPG) mRNA, complete cds.//1.50E-278//506aa//99%//AF302154
  • SKMUS20024750//RAS SUPPRESSOR PROTEIN 1 (RSU-1) (RSP-1 PROTEIN) (RSP-1).//3.90E-21//203aa//33%//Q15404
  • SKMUS20028210
  • SKMUS20028400//Mus musculus YIP1B (Yip1b) mRNA, complete cds.//2.90E-53//142aa//74%//AF217188
  • SKMUS20029200//Homo sapiens ASB-1 protein mRNA, complete cds.//1.20E-45//302aa//39%//AF156777
  • SKMUS20031680
  • SKMUS20046670
  • SKMUS20048970//ACTIN, ALPHA SKELETAL MUSCLE (ALPHA-ACTIN 1).//8.00E-181//263aa//99%//P02568
  • SKMUS20049030//H. sapiens mRNA for nebulin.//3.50E-148//286aa//99%//X83957
  • SKMUS20077400
  • SKMUS20084740
  • SKNMC20006220
  • SKNSH20008190//ZINC FINGER PROTEIN 133.//2.80E-165//503aa//56%//P52736
  • SKNSH20020540
  • SKNSH20028660
  • SKNSH20031740
  • SKNSH20034660
  • SKNSH20051940
  • SKNSH20062340
  • SKNSH20063040//Homo sapiens tetraspan NET-4 mRNA, complete cds.//1.00E-20//177aa//41%//AF065389
  • SKNSH20080430
  • SKNSH20087770
  • SKNSH20089400//Homo sapiens Rad51-interacting protein mRNA, complete-cds.//2.20E-172//292aa//93%//AF006259
  • SKNSH20091970
  • SMINT20001760//ZINC FINGER PROTEIN 83 (ZINC FINGER PROTEIN HPF1).//1.40E-37//138aa//37%//P51522
  • SMINT20005410
  • SMINT20008240
  • SMINT20009840//IG KAPPA CHAIN V-II REGION GM607 PRECURSOR (FRAGMENT).//9.00E-54//117aa//90%//P06309
  • SMINT20011140
  • SMINT20011580
  • SMINT20011990
  • SMINT20013480
  • SMINT20014580
  • SMINT20015590
  • SMINT20022020
  • SMINT20023280
  • SMINT20024570//tektin A1//6.90E-26//124aa//45%//M97188
  • SMINT20026890//SMOOTHELIN.//3.10E-278//611aa//88%//P53814
  • SMINT20028820//Homo sapiens mRNA for F5-2, complete cds.//2.40E-83//162aa//98%//AB020739
  • SMINT20029760
  • SMINT20033170
  • SMINT20033400
  • SMINT20035690
  • SMINT20040860
  • SMINT20042990
  • SMINT20047810
  • SMINT20049090//Homo sapiens mRNA for partial putative mitogen-activated protein kinase kinase kinase.//2.20E-32//69aa//98%//AJ242724
  • SMINT20050750//SPARC PRECURSOR (SECRETED PROTEIN ACIDIC AND RICH IN CYSTEINE) (OSTEONECTIN) (ON) (BASEMENT MEMBRANE PROTEIN BM-40).//4.20E-111//259aa//82%//P09486
  • SMINT20051610//Mus musculus ES18 mRNA, complete cds.//6.90E-235//485aa//88%//AF083929
  • SMINT20053300//Homo sapiens hepatocellular carcinoma-associated antigen 59 mRNA, complete cds.//7.00E-20//44aa//100%//AF218421
  • SMINT20053870
  • SMINT20056210
  • SMINT20058000
  • SMINT20060780
  • SMINT20065960
  • SMINT20068010
  • SMINT20071400
  • SMINT20073650//IG ALPHA-1 CHAIN C REGION.//7.90E-197//353aa//100%//P01876
  • SMINT20076470
  • SMINT20080540
  • SMINT20089170
  • SMINT20092330
  • SMINT20092720
  • SMINT20095050
  • SMINT20098320
  • SMINT20100680
  • SMINT20101440//Human cisplatin resistance associated alpha protein (hCRA alpha) mRNA, complete cds.//1.70E-96//182aa//100%//U78556
  • SMINT20102780//NICOTINATE PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.11) (NAPRTASE).//5.30E-05//123aa//33%//P18133
  • SMINT20103690
  • SMINT20105000
  • SMINT20105330//BETA-GALACTOSIDASE PRECURSOR (EC 3.2.1.23) (LACTASE) (ACID BETA-GALACTOSIDASE).//1.00E-54//138aa//78%//P16278
  • SMINT20106290//FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE (EC 3.2.2.23) (FAPY-DNA GLYCOSYLASE).//7.00E-07//214aa//32%//050606
  • SMINT20106720//Homo sapiens mRNA for immunoglobulin lambda heavy chain.//3.30E-235//477aa//89%//Y14737
  • SMINT20108530
  • SMINT20109970
  • SMINT20110330
  • SMINT20110660//Homo sapiens mammalian inositol hexakisphosphate kinase 2 (IP6K2) mRNA, complete cds.//1.20E-33//68aa//100%//AF177145
  • SMINT20112730//IG ALPHA-1 CHAIN C REGION.//1.70E-196//353aa//99%//P01876
  • SMINT20115880//Kruppe1 associated box (KRAB) zinc finger 1 [Rattus norvegicus]//1.50E-42//211aa//45%//NP—062566
  • SMINT20121220//MYOSIN HEAVY CHAIN, NONMUSCLE TYPE B (CELLULAR MYOSIN HEAVY CHAIN, TYPE B) (NMMHC-B).//1.00E-18//493aa//24%//P35580
  • SMINT20121950//HYPOTHETICAL 70.2 KDA PROTEIN C22E12.10C IN CHROMOSOME I.//5.70E-16//90aa//45%//Q10361
  • SMINT20122850
  • SMINT20122910//Mus musculus StAR-related protein 1-4E mRNA, partial cds.//1.50E-77//170aa//82%//AY007808
  • SMINT20127350//U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA (U1 SNRNP 70 KDA) (SNRP70).//3.50E-14//186aa//32%//P08621
  • SMINT20127930//IG ALPHA-1 CHAIN C REGION.//7.90E-197//353aa//100%//P01876
  • SMINT20130320//Rattus norvegicus MHC class II transactivator type IV (CIITA) mRNA, complete cds.//2.50E-33//645aa//26%//AF251307
  • SMINT20131810
  • SMINT20132280
  • SMINT20136130//IG LAMBDA CHAIN C REGIONS.//4.00E-51//105aa//95%//P01842
  • SMINT20138900//DESMIN.//7.20E-203//425aa//94%//P17661
  • SMINT20144430//IG LAMBDA CHAIN V-I REGION BL2 PRECURSOR.//3.80E-55//130aa//83%//P06316
  • SMINT20144800//Human zinc finger protein zfp6 (ZF6) mRNA, partial cds.//1.60E-139//354aa//70%//U71363
  • SMINT20144890
  • SMINT20152940//Mus musculus ATP-dependent zinc metalloprotease (Afg311) mRNA, complete cds; nuclear gene for mitochondrial product.//1.10E-52//75aa//84%//AF329695
  • SMINT20153260//EXTRACELLULAR MATRIX PROTEIN 1 PRECURSOR (SECRETORY COMPONENT P85).//3.50E-274//476aa//98%//Q16610
  • SMINT20153530
  • SMINT20154540//CHLORINE CHANNEL PROTEIN P64.//1.10E-135//419aa//68%//P35526
  • SMINT20155180//Homo sapiens GBAS (GBAS) mRNA, complete cds.//6.70E-115//142aa//97%//AF029786
  • SMINT20157450
  • SMINT20158100
  • SMINT20161220
  • SMINT20162860
  • SMINT20163960
  • SMINT20164400
  • SMINT20164770
  • SMINT20168570//Homo sapiens mRNA for stabilin-1 (stab1 gene).//5.50E-61//128aa//98%//AJ275213
  • SMINT20173190
  • SMINT20173240
  • SMINT20174360//RHYTHMICALLY EXPRESSED GENE 2 PROTEIN (DREG-2).//6.90E-24//242aa//28%//Q94915
  • SMINT20177360//SPLICING FACTOR, ARGININE/SERINE-RICH 2 (SPLICING FACTOR SC35) (SC-35) (SPLICING COMPONENT, 35 KDA) (PR264 PROTEIN).//6.40E-37//82aa//92%//P30352
  • SMINT20178550
  • SMINT20179740//IG MU CHAIN C REGION.//8.50E-248//454aa//99%//P01871
  • SMINT20183530//GCN20 PROTEIN.//5.50E-118//410aa//52%//P43535
  • SMINT20190170//IG ALPHA-1 CHAIN C REGION.//8.50E-199//353aa//100%//P01876
  • SMINT20191420//AMP DEAMINASE 1 (EC 3.5.4.6) (MYOADENYLATE DEAMINASE) (AMP DEAMINASE ISOFORM M).//5.40E-214//401aa//97%//P23109
  • SMINT20191530//PUTATIVE ATP-DEPENDENT RNA HELICASE DBP73D.//5.00E-85//547aa//42%//P26802
  • SMINT20192000
  • SPLEN10000830
  • SPLEN20000640
  • SPLEN20002220
  • SPLEN20003070
  • SPLEN20006070//ANKYRIN 1 (ERYTHROCYTE ANKYRIN) (ANKYRIN R) (ANKYRINS 2.1 AND 2.2).//1.50E-81//788aa//30%//P16157
  • SPLEN20008390//Human placenta (Diff48) mRNA, complete cds.//4.60E-108//337aa//60%//U49187
  • SPLEN20008740//IMPORTIN ALPHA SUBUNIT (KARYOPHERIN ALPHA SUBUNIT) (SERINE-RICH RNA POLYMERASE I SUPPRESSOR PROTEIN).//5.50E-12//490aa//22%//Q02821
  • SPLEN20008820
  • SPLEN20011410//RHO-GTPASE-ACTIVATING PROTEIN 1 (GTPASE-ACTIVATING PROTEIN RHOGAP) (RHO-RELATED SMALL GTPASE PROTEIN ACTIVATOR) (CDC42 GTPASE-ACTIVATING PROTEIN) (P50-RHOGAP).//1.50E-21//183aa//34%//Q07960
  • SPLEN20013540
  • SPLEN20016260
  • SPLEN20019450
  • SPLEN20020070
  • SPLEN20021660//GAMMA-GLUTAMYLTRANSPEPTIDASE PRECURSOR (EC 2.3.2.2) (GAMMA-GLUTAMYLTRANSFERASE) (GGT).//9.00E-23//167aa//33%//P07314
  • SPLEN20022230
  • SPLEN20023140
  • SPLEN20026950//POSSIBLE GLOBAL TRANSCRIPTION ACTIVATOR SNF2L2 (SNF2-ALPHA).//0//766aa//81%//P51531
  • SPLEN20027440//ANKYRIN 2 (BRAIN ANKYRIN) (ANKYRIN B) (ANKYRIN, NONERYTHROID).//6.10E-25//368aa//30%//Q01484
  • SPLEN20029310
  • SPLEN20031600
  • SPLEN20032040
  • SPLEN20032190
  • SPLEN20033960
  • SPLEN20039240//HEAT SHOCK 70 KDA PROTEIN 1 (HSP70.1) (HSP70-1/HSP70-2).//9.80E-112//213aa//100%//P08107
  • SPLEN20040600
  • SPLEN20054290//Fugu rubripes zinc finger protein, isotocin, fatty acid binding protein, sepiapterin reductase and vasotocin genes, complete cds.//4.20E-180//448aa//71%//U90880
  • SPLEN20076530
  • SPLEN20077500//Mus musculus Niban mRNA, complete cds.//1.30E-39//351aa//31%//AB049355
  • SPLEN20079260//ZINC FINGER PROTEIN 132.//6.30E-117//320aa//61%//P52740
  • SPLEN20079510
  • SPLEN20084600//RING CANAL PROTEIN (KELCH PROTEIN).//5.20E-58//558aa//29%//Q04652
  • SPLEN20095410//ZINC FINGER PROTEIN 184 (FRAGMENT).//6.50E-83//236aa//58%//Q99676
  • SPLEN20095550
  • SPLEN20095810
  • SPLEN20097330
  • SPLEN20099700//TAT-BINDING HOMOLOG 7.//1.50E-142//553aa//48%//P54816
  • SPLEN20101190
  • SPLEN20103950//40S RIBOSOMAL PROTEIN S17.//7.10E-22//49aa//100%//P06584
  • SPLEN20106250
  • SPLEN20117660//Homo sapiens BCL-6 corepressor (BCOR) mRNA, complete cds; alternatively spliced.//1.30E-38//139aa//61%//AF317391
  • SPLEN20118300//Rattus norvegicus amino acid transport system A3 (Ata3) mRNA, complete cds.//1.70E-20//210aa//28%//AF295535
  • SPLEN20119810
  • SPLEN20121750//Danio rerio uridine kinase mRNA, complete cds.//1.60E-29//130aa//50%//AF195851
  • SPLEN20126190
  • SPLEN20128000//Xenopus laevis XMAB21 (Xmab-21) mRNA, complete cds.//6.80E-12//287aa//24%//AF040992
  • SPLEN20129610
  • SPLEN20140800//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//1.20E-145//586aa//47%//P51523
  • SPLEN20141360
  • SPLEN20141990
  • SPLEN20142100//Rattus norvegicus alpha D integrin mRNA, complete cds.//7.10E-37//105aa//76%//AF021334
  • SPLEN20143180//Mus musculus EWS/FLI1 activated transcript 2 (EAT-2) mRNA, complete cds.//2.50E-45//132aa//65%//AF020263
  • SPLEN20144520
  • SPLEN20145720//Rattus norvegicus nuclear GTPase PIKE mRNA, complete cds.//2.00E-24//120aa//45%//AF280816
  • SPLEN20146450//H. sapiens mRNA for plakophilin 2a and b.//1.20E-08//87aa//42%//X97675
  • SPLEN20146690
  • SPLEN20147110//cyclin-E binding protein 1//0//580aa//58%//NP—057407
  • SPLEN20147390//ZINC FINGER PROTEIN 136.//1.40E-105//417aa//49%//P52737
  • SPLEN20149110
  • SPLEN20149190
  • SPLEN20149240//Cricetulus longicaudatus arginine N-methyltransferase p82 isoform mRNA, complete cds, alternatively spliced.//3.50E-259//525aa//86%//AF336043
  • SPLEN20150940//Mus musculus histone deacetylase mHDA1 mRNA, complete cds.//4.20E-187//550aa//51%//AF006602
  • SPLEN20151210//protein tyrosine phosphatase, non-receptor type 13(AP0-1/CD95 (Fas)-associated phosphatase)//3.00E-25//250aa//29%//NP—006255
  • SPLEN20152610
  • SPLEN20152760
  • SPLEN20157300
  • SPLEN20157880//Homo sapiens Ig superfamily receptor LNIR precursor, mRNA, complete cds.//1.70E-05//137aa//29%//AF160477
  • SPLEN20158900
  • SPLEN20158990
  • SPLEN20160450//Homo sapiens mRNA for Hrs, complete cds.//5.60E-28//59aa//100%//D84064
  • SPLEN20160690
  • SPLEN20160980
  • SPLEN20162680//NUCLEAR PROTEIN SNF7.//4.20E-11//189aa//25%//P39929
  • SPLEN20163560
  • SPLEN20165310//Homo sapiens mRNA for immunoglobulin lambda heavy chain.//4.90E-230//477aa//88%//Y14737
  • SPLEN20166270
  • SPLEN20167200//Mus musculus MPS1 gene and mRNA, 3′end.//1.50E-15//46aa//84%//L20315
  • SPLEN20169220
  • SPLEN20169720
  • SPLEN20170310//Homo sapiens Asef mRNA for APC-stimulated guanine nucleotide exchange factor, complete cds.//8.40E-95//305aa//62%//AB042199
  • SPLEN20171210
  • SPLEN20171470
  • SPLEN20171890
  • SPLEN20172120
  • SPLEN20173510//Xenopus laevis putative N-terminal acetyltransferase mRNA, complete cds.//3.90E-210//413aa//66%//AF247679
  • SPLEN20174260
  • SPLEN20176200
  • SPLEN20179180//Homo sapiens EH domain containing 2 (EHD2) mRNA, complete cds.//1.10E-181//340aa//94%//AF181263
  • SPLEN20179810//Mus musculus pecanex 1 mRNA, complete cds.//3.80E-131//534aa//51%//AF096286
  • SPLEN20181810//Mus musculus faciogenital dysplasia protein 2 (Fgd2) mRNA, complete cds.//6.60E-68//144aa//86%//AF017368
  • SPLEN20186430//PROBABLE G PROTEIN-COUPLED RECEPTOR APJ.//2.20E-163//226aa//96%//P35414
  • SPLEN20193110
  • SPLEN20194050//Homo sapiens HOTTL protein mRNA, complete cds.//9.50E-135//264aa//93%//AF078842
  • SPLEN20198110
  • SPLEN20204170
  • SPLEN20211220
  • SPLEN20211570
  • SPLEN20211940
  • SPLEN20212730//CALPAIN 2, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM-ACTIVATED NEUTRAL PROTEINASE) (CANP) (M-TYPE).//1.70E-137//265aa//98%//P17655
  • SPLEN20212950
  • SPLEN20213830
  • SPLEN20214400
  • SPLEN20214580//Mus musculus mdg1-1 mRNA, complete cds.//1.40E-16//39aa//94%//AF190624
  • SPLEN20222270//Mus musculus adaptor protein (Dokl) mRNA, complete cds.//1.10E-42//123aa//61%//AF179242
  • SPLEN20225220
  • SPLEN20242320
  • SPLEN20242730
  • SPLEN20243830//TRANSCRIPTION INITIATION FACTOR TFIID 135 KDA SUBUNIT (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).//4.70E-38//98aa//87%//000268
  • SPLEN20245300//ADP-ribosylation factor binding protein GGA1//3.00E-39//120aa//76%//NP—037497
  • SPLEN20249560
  • SPLEN20250170//PUTATIVE RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR(RHO/RAC GEF) (FACIOGENITAL DYSPLASIA PROTEIN HOMOLOG).//1.40E-51//488aa//27%//P52734
  • SPLEN20250390//CALPAIN 1, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM-ACTIVATED NEUTRAL PROTEINASE) (CANP) (MU-TYPE).//3.00E-55//115aa//94%//P07384
  • SPLEN20252190//ZINC FINGER PROTEIN 135.//6.00E-89//303aa//52%//P52742
  • SPLEN20261440
  • SPLEN20264110
  • SPLEN20267650//ZINC FINGER PROTEIN 184 (FRAGMENT).//5.20E-90//410aa//45%//Q99676
  • SPLEN20273950
  • SPLEN20279950
  • SPLEN20280660
  • SPLEN20283650//Mus musculus ras activator RasGRP (Rasgrp) mRNA, complete cds.//9.80E-54//182aa//57%//AF106070
  • SPLEN20284240//Homo sapiens hOBDPF mRNA for osteoblast differentiation promoting factor, complete cds.//9.80E-93//177aa//98%//AB048363
  • SPLEN20292950//ATP-binding cassette, sub-family A member 8//3.30E-211//469aa//64%//NP—009099
  • SPLEN20293800
  • SPLEN20303970
  • SPLEN20304950//Homo sapiens CAGH32 mRNA, partial cds.//9.60E-44//86aa//98%//U80743
  • SPLEN20305620//DIHYDROOROTATE DEHYDROGENASE PRECURSOR (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (FRAGMENT).//3.60E-59//124aa//96%//Q02127
  • SPLEN20329240
  • STOMA20001830//IG ALPHA-1 CHAIN C REGION.//2.10E-196//353aa//99%//P01876
  • STOMA20005390//IG ALPHA-1 CHAIN C REGION.//7.90E-197//353aa//100%//P01876
  • STOMA20005670//Homo sapiens mRNA for immunoglobulin lambda heavy chain.//1.90E-216//478aa//83%//Y14737
  • STOMA20006400//Homo sapiens IGHG3 gene for immunoglobulin heavy chain gamma 3 constant region, 4-exon hinge, isolate Lib-A2.//8.40E-214//377aa//100%//AJ390247
  • STOMA20006780
  • STOMA20006860//Homo sapiens TOB3 mRNA, complete cds.//1.80E-74//159aa//97%//AF343078
  • STOMA20008880//MYOCILIN PRECURSOR (TRABECULAR MESHWORK-INDUCED GLUCOCORTICOID RESPONSE PROTEIN).//1.00E-196//405aa//91%//Q99972
  • STOMA20010250//Homo sapiens RNA-binding protein (RBMS3) mRNA, complete cds.//7.70E-46//116aa//86%//AF023259
  • STOMA20013890
  • STOMA20026880
  • STOMA20032890//ZINC FINGER PROTEIN CKR1.//5.80E-30//162aa//38%//P30373
  • STOMA20034770//IG ALPHA-1 CHAIN C REGION.//4.40E-196//353aa//99%//P01876
  • STOMA20036460
  • STOMA20046680//FOSB PROTEIN (G0/G1 SWITCH REGULATORY PROTEIN 3).//4.10E-14//36aa//100%//P53539
  • STOMA20048520
  • STOMA20048840
  • STOMA20051200
  • STOMA20056640//Ig lambda chain V region//6.80E-54//150aa//73%//S23626
  • STOMA20056670//IG ALPHA-1 CHAIN C REGION.//7.90E-197//353aa//100%//P01876
  • STOMA20057820
  • STOMA20062130//IG KAPPA CHAIN V-III REGION HAH PRECURSOR.//3.10E-53//129aa//80%//P18135
  • STOMA20062290
  • STOMA20063250//TRANSCRIPTION FACTOR COE3 (EARLY B-CELL FACTOR 3) (EBF-3) (OLF-1/EBF-LIKE 2) (OE-2) (O/E-2).//7.50E-50//105aa//93%//008791
  • STOMA20063980
  • STOMA20064470//PLACENTAL RIBONUCLEASE INHIBITOR (RIBONUCLEASE/ANGIOGENIN INHIBITOR) (RAI) (R1).//3.60E-14//262aa//30%//P13489
  • STOMA20067800
  • STOMA20069040
  • STOMA20072690
  • STOMA20076800
  • STOMA20077450//UBIQUITIN-ACTIVATING ENZYME E1 (A1S9 PROTEIN).//2.70E-228//430aa//97%//P22314
  • STOMA20080500//ATP-binding cassette, sub-family A, member 7, isoform a//1.00E-297//538aa//94%//NP—061985
  • STOMA20083610//IG ALPHA-1 CHAIN C REGION.//7.90E-197//353aa//100%//P01876
  • STOMA20086140
  • STOMA20088380//IG ALPHA-1 CHAIN C REGION.//2.10E-196//352aa//100%//P01876
  • STOMA20092530//Homo sapiens mRNA for immunoglobulin lambda heavy chain.//3.10E-239//477aa//91%//Y14737
  • STOMA20092560
  • STOMA20092890
  • SYNOV20001520//Homo sapiens kappa 1 immunoglobulin light chain mRNA, complete cds.//5.50E-107//236aa//86%//AF113887
  • SYNOV20001730//Human (hybridoma H210) anti-hepatitis A IgG variable region, constant region, complementarity-determining regions mRNA, complete cds.//2.60E-226//479aa//86%//M87789
  • SYNOV20002510//Homo sapiens IGHG3 gene for immunoglobulin heavy chain gamma 3 constant region, 4-exon hinge, isolate Kp-25.//6.60E-214//377aa//100%//AJ390254
  • SYNOV20002790//Human (hybridoma H210) anti-hepatitis A IgG variable region, constant region, complementarity-determining regions mRNA, complete cds.//1.30E-238//476aa//91%//M87789
  • SYNOV20002970//Human (hybridoma H210) anti-hepatitis A IgG variable region, constant region, complementarity-determining regions mRNA, complete cds.//7.00E-226//476aa//86%//M87789
  • SYNOV20003970
  • SYNOV20004260//Homo sapiens mRNA for immunoglobulin lambda heavy chain.//1.10E-225//477aa//86%//Y14737
  • SYNOV20007000//Human (hybridoma H210) anti-hepatitis A IgG variable region, constant region, complementarity-determining regions mRNA, complete cds.//4.00E-239//478aa//91%//M87789
  • SYNOV20008240//Human (hybridoma H210) anti-hepatitis A IgG variable region, constant region, complementarity-determining regions mRNA, complete cds.//4.10E-237//479aa//90%//M87789
  • SYNOV20009230//IG ALPHA-1 CHAIN C REGION.//7.90E-197//353aa//100%//P01876
  • SYNOV20010880//Human (hybridoma H210) anti-hepatitis A IgG variable region, constant region, complementarity-determining regions mRNA, complete cds.//1.60E-233//476aa//89%//M87789
  • SYNOV20011110//Human (hybridoma H210) anti-hepatitis A IgG variable region, constant region, complementarity-determining regions mRNA, complete cds.//6.90E-235//476aa//89%//M87789
  • SYNOV20013000//Ig gamma=immunoglobulin heavy chain [rats, humanized lympholytic MoAb CAMPATH-1H, mRNA, 1465 nt].//7.70E-220//472aa//86%//S79307
  • SYNOV20013560//Homo sapiens mRNA for immunoglobulin lambda heavy chain.//1.40E-234//477aa//89%//Y14737
  • SYNOV20013900//Homo sapiens mRNA for immunoglobulin kappa heavy chain.//3.50E-231//476aa//89%//Y14735
  • SYNOV20017080
  • SYNOV30001840
  • TBAES20000590
  • TBAES20002550//AMINOPEPTIDASE B (EC 3.4.11.6) (ARGINYL AMINOPEPTIDASE) (ARGININE AMINOPEPTIDASE) (CYTOSOL AMINOPEPTIDASE IV) (AP-B).//2.10E-310//586aa//89%//009175
  • TBAES20003150//CYTOCHROME P450 4A1 (EC 1.14.15.3) (CYPIVA1) (LAURIC ACID OMEGA-HYDROXYLASE) (P450-LA-OMEGA 1) (P452).//1.40E-82//323aa//44%//P08516
  • TBAES20003770//SPERM-SPECIFIC ANTIGEN 2 (CLEAVAGE SIGNAL-1 PROTEIN) (CS-1).//1.90E-122//249aa//97%//P28290
  • TCOLN20001390
  • TESOP20000900
  • TESOP20003120
  • TESOP20004000//CATHEPSIN B PRECURSOR (EC 3.4.22.1) (CATHEPSIN B1) (APP SECRETASE).//3.30E-111//194aa//98%//P07858
  • TESOP20005270//MONOAMINE-SULFATING PHENOL SULFOTRANSFERASE (EC 2.8.2.1) (SULFOTRANSFERASE, MONOAMINE-PREFERRING) (M-PST) (THERMOLABILE PHENOL SULFOTRANSFERASE) (TL-PST) (PLACENTAL ESTROGEN SULFOTRANSFERASE) (CATECHOLAMINE-SULFATING PHENOL SULFOTRANSFERASE) (HAST3).//3.40E-47//92aa//100%//P50224
  • TESOP20005690//Mus musculus p53 apoptosis-associated target (Perp) mRNA, complete cds.//2.30E-53//113aa//91%//AF249870
  • TESTI10000940
  • TESTI20001000//FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE (EC 3.2.2.23) (FAPY-DNA GLYCOSYLASE).//7.80E-06//238aa//28%//P74290
  • TESTI20001170
  • TESTI20001720
  • TESTI20002720//TUBULIN-TYROSINE LIGASE (EC 6.3.2.25) (TTL).//1.70E-18//237aa//29%//P38584
  • TESTI20002780//ADENYLATE CYCLASE (EC 4.6.1.1) (ATP PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE).//1.90E-11//140aa//36%//P08678
  • TESTI20004890
  • TESTI20011200
  • TESTI20017950
  • TESTI20018230
  • TESTI20023510
  • TESTI20029930
  • TESTI20030310
  • TESTI20030890
  • TESTI20031270//TUMOR NECROSIS FACTOR, ALPHA-INDUCED PROTEIN 1, ENDOTHELIAL (B12 PROTEIN).//7.30E-52//146aa//71%//Q13829
  • TESTI20031810
  • TESTI20035960//VEGETATIBLE INCOMPATIBILITY PROTEIN HET-E-1.//1.70E-67//329aa//40%//Q00808
  • TESTI20036380//DRA PROTEIN (DOWN-REGULATED IN ADENOMA).//6.40E-46//243aa//35%//P40879
  • TESTI20037560
  • TESTI20038270
  • TESTI20039400//EBNA-1 NUCLEAR PROTEIN.//3.60E-43//298aa//43%//P03211
  • TESTI20041690//TRANSCRIPTION INTERMEDIARY FACTOR 1-BETA (KRAB-A INTERACTING PROTEIN) (KRIP-1).//1.00E-12//341aa//21%//Q62318
  • TESTI20044230//Mus musculus testis-specific Y-encoded-like protein (Tspyl1) mRNA, complete cds.//1.70E-94//291aa//64%//AF042180
  • TESTI20044310//RAS SUPPRESSOR PROTEIN 1 (RSU-1) (RSP-1 PROTEIN) (RSP-1).//6.70E-06//118aa//32%//Q15404
  • TESTI20046750
  • TESTI20057750
  • TESTI20060400//Columba livia mRNA for 5′-nucleotidase.//3.80E-115//328aa//66%//AJ131243
  • TESTI20061110//Xenopus laevis katanin p60 mRNA, partial cds.//1.80E-170//489aa//66%//AF177942
  • TESTI20063830//Drosophila melanogaster nuclear fallout (nuf) mRNA, nuf-1 allele, complete cds.//2.10E-34//371aa//29%//AF045015
  • TESTI20066670//probable acyl-CoA dehydrogenase//1.90E-72//222aa//60%//D75616
  • TESTI20066770
  • TESTI20067200//PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR-3 (HOMEOBOX PROTEIN PBX3).//4.20E-132//352aa//71%//P40426
  • TESTI20076850
  • TESTI20082330//helicase II homolog//4.10E-44//775aa//25%//T13889
  • TESTI20083200//Homo sapiens mitogen-activated protein kinase phosphatase x (MKPX) mRNA, complete cds.//1.00E-41//131aa//58%//AF165519
  • TESTI20083940
  • TESTI20086210
  • TESTI20087620
  • TESTI20088220//ZINC FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10) (HPF7).//8.50E-175//633aa//48%//Q05481
  • TESTI20094020
  • TESTI20094120
  • TESTI20094230//Strongylocentrotus purpuratus tektin A1 mRNA, complete cds//4.50E-64//252aa//50%//M97188
  • TESTI20094470//ETS-RELATED PROTEIN 71 (ETS TRANSLOCATION VARIANT 2).//1.40E-183//318aa//99%//000321
  • TESTI20098350
  • TESTI20098530
  • TESTI20102800
  • TESTI20105720
  • TESTI20108720//PROTEIN PHOSPHATASE 2C BETA ISOFORM (EC 3.1.3.16) (PP2C-BETA) (IA) (PROTEIN PHOSPHATASE 1B).//3.30E-49//249aa//46%//P36993
  • TESTI20110280
  • TESTI20112940
  • TESTI20114070
  • TESTI20116650
  • TESTI20116830//Homo sapiens liprin-beta2 mRNA, partial cds.//8.20E-17//50aa//92%//AF034803
  • TESTI20121550//NUCLEOPORIN-LIKE PROTEIN RIP (REV INTERACTING PROTEIN) (REV/REX ACTIVATION DOMAIN-BINDING PROTEIN).//1.60E-152//363aa//85%//P52594
  • TESTI20122310
  • TESTI20123080
  • TESTI20123560
  • TESTI20127760
  • TESTI20128350
  • TESTI20129150
  • TESTI20129220
  • TESTI20130010//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//2.10E-63//173aa//65%//P51523
  • TESTI20130120
  • TESTI20135660
  • TESTI20136100//ZINC/CADMIUM RESISTANCE PROTEIN.//3.70E-12//101aa//35%//P20107
  • TESTI20136710
  • TESTI20136990
  • TESTI20137370
  • TESTI20137670
  • TESTI20143240
  • TESTI20143390//Mus musculus testicular condensing enzyme (AMAC1) mRNA, complete cds.//1.60E-51//123aa//79%//AF016712
  • TESTI20143620
  • TESTI20148000//PROTEIN DISULFIDE ISOMERASE (PDI) (EC 5.3.4.1) (PROLYL 4-HYDROXYLASE BETA SUBUNIT) (CELLULAR THYROID HORMONE BINDING PROTEIN) (RETINA COGNIN) (R-COGNIN).//2.80E-75//493aa//34%//P09102
  • TESTI20152460//ML02 PROTEIN.//9.60E-42//170aa//40%//Q09329
  • TESTI20155900
  • TESTI20156100//KRUPPEL-LIKE FACTOR 4 (EPITHELIAL ZINC-FINGER PROTEIN EZF).//2.30E-32//254aa//32%//043474
  • TESTI20157100
  • TESTI20157520
  • TESTI20159140
  • TESTI20161970
  • TESTI20164100
  • TESTI20168480//H. sapiens mRNA for titin protein (clone hh1-hh54).//6.30E-48//393aa//31%//X90568
  • TESTI20168630
  • TESTI20168960
  • TESTI20169960
  • TESTI20170350
  • TESTI20171020
  • TESTI20178160
  • TESTI20179320
  • TESTI20183370
  • TESTI20184620//OXYSTEROL-BINDING PROTEIN.//6.20E-27//181aa//28%//P16258
  • TESTI20185650//Xenopus laevis ubiquitin-like fusion protein mRNA, complete cds.//2.90E-129//543aa//46%//L08474
  • TESTI20185810
  • TESTI20189410//Mus musculus axotrophin mRNA, complete cds.//7.50E-43//142aa//57%//AF155739
  • TESTI20192280
  • TESTI20192800//Homo sapiens nasopharyngeal carcinoma susceptibility protein LZ16 mRNA, complete cds.//2.40E-23//164aa//41%//AF121775
  • TESTI20193360
  • TESTI20194300
  • TESTI20194810
  • TESTI20197940
  • TESTI20199170
  • TESTI20199750//TRICHOHYALIN.//8.80E-59//547aa//30%//P37709
  • TESTI20200260
  • TESTI20200710//Mus musculus epithelial protein lost in neoplasm-a (Eplin) mRNA, complete cds.//4.40E-40//212aa//42%//AF307844
  • TESTI20202650
  • TESTI20203440
  • TESTI20204450//M. musculus of DNA encoding DNA-binding protein.//1.90E-58//477aa//32%//Z54200
  • TESTI20208400//PROLIFERATING-CELL NUCLEOLAR ANTIGEN P120 (PROLIFERATION-ASSOCIATED NUCLEOLAR PROTEIN P120).//1.70E-16//181aa//33%//P46087
  • TESTI20208710
  • TESTI20209460
  • TESTI20209810
  • TESTI20209990
  • TESTI20211160
  • TESTI20211220
  • TESTI20211240
  • TESTI20213150
  • TESTI20213580
  • TESTI20214250//MITOCHONDRIAL CARRIER PROTEIN PMT.//1.10E-34//242aa//36%//P32332
  • TESTI20215990//Homo sapiens leucine-rich repeats containing F-box protein FBL3 mRNA, complete cds.//1.10E-39//375aa//28%//AF186273
  • TESTI20216370//LIVER CARBOXYLESTERASE PRECURSOR (EC 3.1.1.1) (ES-MALE) (ESTERASE-31).//1.50E-60//164aa//68%//Q63880
  • TESTI20220100
  • TESTI20220650
  • TESTI20224620
  • TESTI20226230//Rattus norvegicus KPL2 (Kpl2) mRNA, complete cds.//8.90E-111//371aa//59%//AF102129
  • TESTI20226490
  • TESTI20229600//Drosophila melanogaster SP2353 mRNA, complete cds.//8.30E-117//607aa//33%//AF239610
  • TESTI20230250
  • TESTI20230850//CIRCADIAN LOCOMOTER OUTPUT CYCLES KAPUT PROTEIN (MCLOCK).//1.00E-23//186aa//30%//008785
  • TESTI20231920
  • TESTI20231940//Human OB binding protein-2 (OB-BP2) mRNA, complete cds.//4.60E-14//140aa//36%//U71383
  • TESTI20232140//1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1 (EC 3.1.4.11) (PLC-DELTA-1) (PHOSPHOLIPASE C-DELTA-1) (PLC-III) (FRAGMENT).//2.50E-90//388aa//47%//P10895
  • TESTI20234140
  • TESTI20234270
  • TESTI20234360//PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1 (EC 5.2.1.8).//5.90E-66//128aa//98%//Q13526
  • TESTI20237520//poly(A)-specific ribonuclease (deadenylation nuclease)//1.10E-34//311aa//26%//NP—002573
  • TESTI20238000
  • TESTI20238610//MELANOMA-ASSOCIATED ANTIGEN B1 (MAGE-B1 ANTIGEN) (MAGE-XP ANTIGEN) (DAM10).//6.80E-69//268aa//51%//P43366
  • TESTI20239470
  • TESTI20239510//ubiquitin specific protease 6//5.60E-43//182aa//50%//NP—004496
  • TESTI20240090
  • TESTI20241530
  • TESTI20241920
  • TESTI20242830
  • TESTI20242990
  • TESTI20244190//Homo sapiens IGHG3 gene for immunoglobulin heavy chain gamma 3 constant region, 4-exon hinge, isolate Lib-A2.//8.40E-214//377aa//100%//AJ390247
  • TESTI20244760
  • TESTI20249990//ATAXIN 7 (SPINOCEREBELLAR ATAXIA TYPE 7 PROTEIN).//7.30E-49//388aa//37%//015265
  • TESTI20254220
  • TESTI20254540//Homo sapiens hepatocellular carcinoma-associated antigen 59 mRNA, complete cds.//1.60E-100//197aa//98%//AF218421
  • TESTI20254860//TUMOR SUPPRESSOR PROTEIN DCC PRECURSOR.//1.20E-35//564aa//28%//P70211
  • TESTI20255820
  • TESTI20258460//Homo sapiens OSBP-related protein 4 mRNA, complete cds.//8.20E-196//369aa//99%//AF323731
  • TESTI20262330
  • TESTI20262910
  • TESTI20265250
  • TESTI20265370
  • TESTI20265970
  • TESTI20266740//Homo sapiens topoisomerase-related function protein (TRF4-1) mRNA, partial cds.//2.70E-105//278aa//71%//AF089896
  • TESTI20269570
  • TESTI20271850
  • TESTI20272060
  • TESTI20272390
  • TESTI20272960//Mus musculus gene for odorant receptor MOR83, complete cds.//3.30E-84//306aa//50%//AB030894
  • TESTI20275030
  • TESTI20275620
  • TESTI20277360
  • TESTI20278200
  • TESTI20278400//INTRACELLULAR PROTEIN TRANSPORT PROTEIN USO1.//2.50E-11//604aa//21%//P25386
  • TESTI20280980
  • TESTI20282540
  • TESTI20284880
  • TESTI20285830
  • TESTI20288110
  • TESTI20288910//Mus musculus endophilin II mRNA, complete cds.//2.10E-110//225aa//92%//U58885
  • TESTI20289850
  • TESTI20291310
  • TESTI20291620
  • TESTI20291960//RHOMBOID PROTEIN (VEINLET PROTEIN).//2.00E-40//230aa//38%//P20350
  • TESTI20294700
  • TESTI20297850
  • TESTI20301360
  • TESTI20303220//Rattus norvegicus neural cell adhesion protein BIG-2 precursor (BIG-2) mRNA, complete cds.//0//807aa//94%//U35371
  • TESTI20303360
  • TESTI20303420
  • TESTI20305540//M. musculus mRNA for IB3/5-polypeptide.//1.30E-183//684aa//56%//X79131
  • TESTI20305560
  • TESTI20307540
  • TESTI20307700
  • TESTI20308600
  • TESTI20309170//Mucor circinelloides crgA gene for carotenoid regulatory protein.//3.10E-41//198aa//40%//AJ250998
  • TESTI20310070
  • TESTI20311290
  • TESTI20314180//TRYPSIN I-PI PRECURSOR (EC 3.4.21.4).//2.10E-25//86aa//40%//Q90627
  • TESTI20316870//Homo sapiens mRNA for cartilage-associated protein (CASP).//4.90E-106//199aa//99%//AJ006470
  • TESTI20317600
  • TESTI20318090//ZINC FINGER PROTEIN 135.//2.00E-56//208aa//50%//P52742
  • TESTI20319190
  • TESTI20320440//THIOREDOXIN.//4.30E-32//103aa//63%//P50413
  • TESTI20320670//Rattus norvegicus mRNA for type A/B hnRNP protein p40.//2.20E-170//337aa//91%//AJ238854
  • TESTI20326810//RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN (RAN BINDING PROTEIN 1) (RANBP1).//2.00E-33//66aa//100%//P34022
  • TESTI20327680
  • TESTI20327740
  • TESTI20328280
  • TESTI20330310
  • TESTI20332420//Mus musculus cell cycle checkpoint control protein Mrad9 gene, complete cds.//5.80E-20//246aa//28%//AF045662
  • TESTI20333000
  • TESTI20333950
  • TESTI20334410//Sus scrofa RNA helicase (RHIV-1) mRNA, complete cds.//4.40E-58//281aa//33%//AF181119
  • TESTI20335050//Homo sapiens cell cycle checkpoint protein CHFR mRNA, complete cds.//6.00E-188//333aa//99%//AF170724
  • TESTI20335200//BILIARY GLYCOPROTEIN 1 PRECURSOR (BGP-1) (ANTIGEN CD66) (CD66A ANTIGEN).//8.10E-20//87aa//50%//P13688
  • TESTI20336410
  • TESTI20337100
  • TESTI20342430
  • TESTI20343070
  • TESTI20343570//TRIPEPTIDYL-PEPTIDASE II (EC 3.4.14.10) (TPP II) (TRIPEPTIDYL AMINOPEPTIDASE).//2.00E-75//201aa//75%//P29144
  • TESTI20345060
  • TESTI20347180//Mus musculus membrane protein TMS-2 mRNA, complete cds.//6.00E-35//186aa//41%//AF181685
  • TESTI20347300
  • TESTI20347740
  • TESTI20347770
  • TESTI20351830
  • TESTI20352620//PROACTIVATOR POLYPEPTIDE PRECURSOR [CONTAINS: SAPOSIN A (PROTEIN A); SAPOSIN B (SPHINGOLIPID ACTIVATOR PROTEIN 1) (SAP-1) (DISPERSIN) (SULFATIDE/GM1 ACTIVATOR); SAPOSIN C(CO-BETA-GLUCOSIDASE) (A1 ACTIVATOR) (GLUCOSYLCERAMIDASE ACTIVATOR) (SPHINGOLIPID ACTIVATOR PROTEIN 2) (SAP-2); SAPOSIN D (PROTEIN C) (COMPONENT C)].//1.30E-52//240aa//44%//P07602
  • TESTI20355020//Drosophila sp. Hls (hls) mRNA, complete cds.//9.80E-30//416aa//28%//S79915
  • TESTI20357750
  • TESTI20357930
  • TESTI20357960
  • TESTI20358980//Volvox carteri mRNA for hydroxyproline-rich glycoprotein (HRGP gene).//2.90E-37//155aa//50%//AJ242540
  • TESTI20361140
  • TESTI20366910//Homo sapiens mRNA for thioredoxin reductase II beta, complete cds.//2.00E-233//442aa//93%//AB019695
  • TESTI20367360
  • TESTI20368330//M-PHASE INDUCER PHOSPHATASE 3 (EC 3.1.3.48).//2.10E-258//473aa//99%//P30307
  • TESTI20369130
  • TESTI20369220
  • TESTI20369650//Homo sapiens mRNA for HsGAK, complete cds.//2.40E-269//493aa//99%//D88435
  • TESTI20369690
  • TESTI20370020
  • TESTI20370550
  • TESTI20370810//Homo sapiens mRNA for LAK-4p, complete cds.//1.10E-74//385aa//38%//AB002405
  • TESTI20371030//TIP ELONGATION ABERRANT PROTEIN 1 (CELL POLARITY PROTEIN TEA1).//7.80E-23//243aa//29%//P87061
  • TESTI20371060
  • TESTI20373820
  • TESTI20375340//1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1 (EC 3.1.4.11) (PLC-DELTA-1) (PHOSPHOLIPASE C-DELTA-1) (PLC-III) (FRAGMENT).//4.80E-68//273aa//45%//P10895
  • TESTI20377230
  • TESTI20378190//ZINC FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10) (HPF7).//2.30E-114//323aa//52%//Q05481
  • TESTI20378450
  • TESTI20380650
  • TESTI20381040
  • TESTI20382750//Homo sapiens hook1 protein (HOOK1) mRNA, complete cds.//2.60E-96//195aa//99%//AF044923
  • TESTI20383880//Homo sapiens gamma cysteine string protein mRNA, partial cds.//6.50E-61//109aa//100%//AF368277
  • TESTI20385960//Homo sapiens mRNA for RET finger protein-like 3.//4.80E-156//288aa//100%//AJ010232
  • TESTI20386230
  • TESTI20386440
  • TESTI20388580
  • TESTI20390260
  • TESTI20390410
  • TESTI20391130
  • TESTI20391210
  • TESTI20391770
  • TESTI20392090
  • TESTI20392250//Homo sapiens VAV-3 protein mRNA, complete cds.//9.80E-145//268aa//98%//AF067817
  • TESTI20392270
  • TESTI20392760//PROTEIN PHOSPHATASES PP1 REGULATORY SUBUNIT SDS22.//5.70E-22//226aa//31%//P36047
  • TESTI20393530//MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN PRECURSOR (PTP).//9.00E-34//105aa//68%//P12234
  • TESTI20396130
  • TESTI20397760//POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE IIB (EC 3.6.1.-).//1.60E-109//221aa//90%//P98195
  • TESTI20400940//CENTROMERIC PROTEIN E (CENP-E PROTEIN).//4.70E-16//669aa//23%//Q02224
  • TESTI20401020//Oryctolagus cuniculus peroxisomal Ca-dependent solute carrier mRNA, complete cds.//5.80E-64//234aa//56%//AF004161
  • TESTI20401280
  • TESTI20401430
  • TESTI20404240//INTERFERON-RELATED DEVELOPMENTAL REGULATOR 2 (SKMC15 PROTEIN).//4.60E-36//46aa//93%//Q12894
  • TESTI20406420
  • TESTI20408150
  • TESTI20408970//NUCLEAR ENVELOPE PORE MEMBRANE PROTEIN POM 121 (PORE MEMBRANE PROTEIN OF 121 KDA) (P145).//4.30E-16//264aa//30%//P52591
  • TESTI20409440
  • TESTI20409890//GCD14 PROTEIN.//2.30E-46//263aa//40%//P46959
  • TESTI20413300
  • TESTI20415170
  • TESTI20415640
  • TESTI20416640//CHOLINE/ETHANOLAMINE KINASE [INCLUDES: CHOLINE KINASE (EC 2.7.1.32) (CK); ETHANOLAMINE KINASE (EC 2.7.1.82) (EK)].//2.10E-77//139aa//100%//Q9Y259
  • TESTI20417300//DYNEIN BETA CHAIN, CILIARY.//6.80E-129//552aa//45%//P39057
  • TESTI20419560
  • TESTI20420620//TRANSCRIPTION INITIATION FACTOR TFIID 70 KDA SUBUNIT (TAFII-70) (TAFII-80) (TAFII80).//0//526aa//99%//P49848
  • TESTI20421490
  • TESTI20422640
  • TESTI20423020
  • TESTI20424000
  • TESTI20424730
  • TESTI20425070
  • TESTI20427830
  • TESTI20428060
  • TESTI20429280
  • TESTI20429580
  • TESTI20432750//Mus musculus pantothenate kinase 1 beta (panKlbeta) mRNA, complete cds.//9.70E-165//363aa//82%//AF200357
  • TESTI20432820//ZINC FINGER PROTEIN 43 (ZINC PROTEIN HTF6).//1.00E-173//403aa//75%//P28160
  • TESTI20433130
  • TESTI20436560//LAMIN C.//9.20E-235//453aa//99%//PO2546
  • TESTI20438570//Homo sapiens nolp mRNA, complete cds.//2.70E-43//146aa//60%//AB017800
  • TESTI20438660
  • TESTI20441940//Human K-Cl cotransporter (hKCC1) mRNA, complete cds.//5.50E-139//264aa//99%//U55054
  • TESTI20442760//Homo sapiens Ig-like membrane protein (IGSF3) mRNA, complete cds.//0//545aa//93%//AF031174
  • TESTI20443090//DNA REPAIR PROTEIN RAD51 HOMOLOG 4 (R51H3) (TRAD).//2.70E-68//141aa//100%//075771
  • TESTI20444130
  • TESTI20444180
  • TESTI20447540
  • TESTI20449200//METABOTROPIC GLUTAMATE RECEPTOR 7 PRECURSOR.//9.00E-173//313aa//99%//Q14831
  • TESTI20451710
  • TESTI20451990
  • TESTI20455090//KERATIN, TYPE I CYTOSKELETAL 18 (CYTOKERATIN 18) (K18) (CK 18).//1.20E-76//199aa//80%//P05783
  • TESTI20455620//HEAT SHOCK-RELATED 70 KDA PROTEIN 2 (HEAT SHOCK 70 KDA PROTEIN 2).//4.80E-218//336aa//99%//P54652
  • TESTI20456110//52 KDA RO PROTEIN (SJOGREN SYNDROME TYPE A ANTIGEN (SS-A)) (RO(SS-A)).//9.40E-75//382aa//43%//P19474
  • TESTI20458190
  • TESTI20463520
  • TESTI20463580//UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4 (EC 3.1.2.15) (UBIQUITIN THIOLESTERASE 4) (UBIQUITIN-SPECIFIC PROCESSING PROTEASE 4) (DEUBIQUITINATING ENZYME 4) (UBIQUITOUS NUCLEAR PROTEIN HOMOLOG).//1.50E-17//190aa//28%//Q13107
  • TESTI20465350//2′,3′-CYCLIC NUCLEOTIDE 3′-PHOSPHODIESTERASE (EC 3.1.4.37) (CNP) (CNPASE).//2.20E-123//231aa//100%//P09543
  • TESTI20465520
  • TESTI20465690//Homo sapiens Borg4 mRNA, complete cds.//2.00E-152//235aa//99%//AB042237
  • TESTI20467210//Homo sapiens mRNA for HELG protein.//2.00E-166//368aa//83%//AJ277291
  • TESTI20467320//Mus musculus WAVE-1 mRNA, complete cds.//1.20E-111//233aa//88%//AF290877
  • TESTI20467970
  • TESTI20468630
  • TESTI20471410//PROTEIN PHOSPHATASE 2C ALPHA ISOFORM (EC 3.1.3.16) (PP2C-ALPHA) (IA) (PROTEIN PHOSPHATASE IA).//1.30E-210//382aa//99%//P35813
  • TESTI20471470
  • TESTI20471530
  • TESTI20472120
  • TESTI20473420
  • TESTI20473830//Columba livia mRNA for 5′-nucleotidase.//2.00E-14//75aa//49%//AJ131243
  • TESTI20477920
  • TESTI20478010
  • TESTI20478180
  • TESTI20478850
  • TESTI20479300
  • THYMU10005360//Human T cell receptor beta chain (TCRB) mRNA, VNDNJC region, 5′end.//1.20E-130//270aa//91%//L07294
  • THYMU10005540//Homo sapiens mRNA for immunoglobulin lambda heavy chain.//1.20E-237//479aa//90%//Y14737
  • THYMU20000570
  • THYMU20011950
  • THYMU20015210
  • THYMU20018190
  • THYMU20023380//Homo sapiens m6A methyltransferase (MT-A70) gene, complete cds.//1.20E-38//86aa//100%//AF014837
  • THYMU20027560
  • THYMU20029100
  • THYMU20032870
  • THYMU20039810//MPS1 protein//2.60E-283//646aa//77%//152603
  • THYMU20045120
  • THYMU20058070
  • THYMU20061700
  • THYMU20066100
  • THYMU20070360
  • THYMU20075320
  • THYMU20081490//Homo sapiens ICB-1 mRNA, complete cds.//1.50E-23//267aa//33%//AF044896
  • THYMU20095960
  • THYMU20100410
  • THYMU20101610
  • THYMU20101920
  • THYMU20105190//MYOSIN I ALPHA (MMI-ALPHA).//7.50E-54//282aa//45%//P46735
  • THYMU20106710//Homo sapiens T-cell receptor alpha delta locus from bases 501613 to 752736 (section 3 of 5) of the Complete Nucleotide Sequence.//1.20E-54//113aa//98%//AE000660
  • THYMU20108310//Mouse NCBP-29 mRNA for PW29, complete cds.//7.70E-93//102aa//99%//D49429
  • THYMU20111180
  • THYMU20111420
  • THYMU20111830//protease, serine, 16 (thymus)//1.40E-129//175aa//98%//NP—005856
  • THYMU20114470
  • THYMU20115850
  • THYMU20118060
  • THYMU20118520//Xenopus laevis ubiquitin-like fusion protein mRNA, complete cds//3.00E-42//109aa//77%//L08475
  • THYMU20119390
  • THYMU20122730//target of mybl (chicken) homolog//1.00E-122//233aa//100%//NP—005479
  • THYMU20126900//UDP-GLUCOSE 6-DEHYDROGENASE (EC 1.1.1.22) (UDP-GLC DEHYDROGENASE) (UDP-GLCDH) (UDPGDH).//1.40E-229//341aa//99%//060701
  • THYMU20128070
  • THYMU20128260
  • THYMU20130890//40S RIBOSOMAL PROTEIN S16.//1.90E-28//125aa//57%//P17008
  • THYMU20141670
  • THYMU20142040//WISKOTT-ALDRICH SYNDROME PROTEIN HOMOLOG (WASP).//2.60E-12//155aa//32%//P70315
  • THYMU20142970
  • THYMU20143270//Homo sapiens HSNFRK (HSNFRK) mRNA, complete cds.//5.40E-171//321aa//100%//AF226044
  • THYMU20147770//Homo sapiens mRNA for immunoglobulin lambda heavy chain.//5.40E-235//477aa//89%//Y14737
  • THYMU20153160
  • THYMU20158250
  • THYMU20159430//IG ALPHA-1 CHAIN C REGION.//7.90E-197//353aa//100%//P01876
  • THYMU20161640//Mus musculus p53 apoptosis-associated target (Perp) mRNA, complete cds.//1.40E-92//188aa//89%//AF249870
  • THYMU20162190
  • THYMU20169680//DIACYLGLYCEROL KINASE, ZETA (EC 2.7.1.107) (DIGLYCERIDE KINASE) (DGK-ZETA) (DAG KINASE ZETA).//1.40E-64//124aa//99%//Q13574
  • THYMU20172150//CORONIN-LIKE PROTEIN P57 (CORONIN 1A).//1.60E-49//96aa//100%//P31146
  • THYMU20173980
  • THYMU20180280//RED PROTEIN (RER PROTEIN) (IK FACTOR) (CYTOKINE IK).//2.60E-40//83aa//96%//Q13123
  • THYMU20186390
  • THYMU20186730
  • THYMU20187720
  • THYMU20193640//HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L (HNRNP L).//1.70E-82//157aa//99%//P14866
  • THYMU20194360
  • THYMU20194420
  • THYMU20195990
  • THYMU20201980//Mus musculus faciogenital dysplasia protein 2 (Fgd2) mRNA, complete cds.//2.90E-122//259aa//86%//AF017368
  • THYMU20202890//PROTEIN KINASE CLK3 (EC 2.7.1.-).//1.10E-204//367aa//99%//035492
  • THYMU20204160
  • THYMU20204990
  • THYMU20208300
  • THYMU20209590//DYNAMIN 2.//2.10E-189//363aa//97%//P50570
  • THYMU20215090
  • THYMU20215970
  • THYMU20216840
  • THYMU20222890
  • THYMU20226600
  • THYMU20228540
  • THYMU20229220
  • THYMU20232090//SYNTAXIN BINDING PROTEIN 2 (UNC-18 HOMOLOG 2) (UNC-18B).//2.10E-54//112aa//99%//Q15833
  • THYMU20235760
  • THYMU20239000//collagen alpha 1(XI) chain//1.70E-37//579aa//33%//S18251
  • THYMU20239430
  • THYMU20240710//Halocynthia roretzi mRNA for HrPET-3, complete cds.//5.60E-54//155aa//44%//AB029335
  • THYMU20241210//Homo sapiens mRNA for nuclear protein, NP220, complete cds.//2.00E-58//117aa//100%//D83032
  • THYMU20241850//HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DX BETA CHAIN PRECURSOR.//4.40E-141//261aa//100%//P05538
  • THYMU20246840
  • THYMU20247480//ZINC FINGER PROTEIN 135.//1.20E-97//191aa//90%//P52742
  • THYMU20250420
  • THYMU20251890
  • THYMU20253250
  • THYMU20255570
  • THYMU20255720
  • THYMU20259090
  • THYMU20265300
  • THYMU20271250
  • THYMU20272490
  • THYMU20277390
  • THYMU20279750
  • THYMU20283790
  • THYMU20284120
  • THYMU20286290
  • THYMU20286320
  • TKIDN10000010//translocase of inner mitochondrial membrane 23 (yeast) homolog//6.30E-67//133aa//98%//NP—006318
  • TKIDN20004640//GALACTOKINASE 2 (EC 2.7.1.6).//5.10E-99//200aa//97%//Q01415
  • TKIDN20005210
  • TKIDN20030590
  • TKIDN20030620
  • TKIDN20047480//MITOGEN-ACTIVATED PROTEIN KINASE 12 (EC 2.7.1.-) (EXTRACELLULAR SIGNAL-REGULATED KINASE 6) (EC 2.7.1.-) (ERK6) (ERK5) (STRESS-ACTIVATED PROTEIN KINASE-3) (MITOGEN-ACTIVATED PROTEIN KINASE P38 GAMMA) (MAP KINASE P38 GAMMA).//2.20E-52//104aa//100%//P53778
  • TOVAR20004760
  • TOVAR20005750
  • TRACH20002870//CLAUDIN-6.//1.30E-27//175aa//42%//Q9Z262
  • TRACH20003590//CYTOCHROME P450 4A4 (EC 1.14.14.1) (CYPIVA4) (PROSTAGLANDIN OMEGA-HYDROXYLASE) (P450-P-2).//1.50E-138//493aa//49%//P10611
  • TRACH20005020
  • TRACH20005400//Mus musculus GTPase Rab37 (Rab37) mRNA, complete cds.//3.30E-109//223aa//93%//AF233582
  • TRACH20007020//TRICHOHYALIN.//5.60E-24//532aa//23%//P37709
  • TRACH20016210//ALPHA-(1,3)-FUCOSYLTRANSFERASE (EC 2.4.1.65) (GALACTOSIDE 3-L-FUCOSYLTRANSFERASE) (FUCOSYLTRANSFERASE 6) (FUCT-VI).//5.00E-192//254aa//99%//P51993
  • TRACH20019960//SODIUM/POTASSIUM-TRANSPORTING ATPASE ALPHA-1 CHAIN PRECURSOR (EC 3.6.1.37) (SODIUM PUMP) (NA+/K+ ATPASE).//9.50E-185//410aa//84%//P05023
  • TRACH20027840
  • TRACH20028030//Mus musculus mmDNAJA4 mRNA for mmDj4, complete cds.//8.50E-205//397aa//92%//AB032401
  • TRACH20029540
  • TRACH20032720
  • TRACH20033230//MALTOSE PERMEASE.//1.20E-10//197aa//23%//Q45632
  • TRACH20034840//SKIN SECRETORY PROTEIN XP2 PRECURSOR (APEG PROTEIN).//5.90E-14//342aa//28%//P17437
  • TRACH20037360
  • TRACH20041830//Aedes triseriatus putative disulfide-isomerase mRNA, partial cds.//3.10E-29//134aa//47%//AF306866
  • TRACH20042920//Human C3f mRNA, complete cds.//7.80E-195//381aa//89%//U72515
  • TRACH20048450//PROTEIN K4 (PROTEIN K3).//4.70E-57//431aa//32%//P18377
  • TRACH20050040//PUTATIVE SURFACE GLYCOPROTEIN C210RF1 PRECURSOR (C210RF3).//8.50E-74//177aa//74%//P53801
  • TRACH20056980
  • TRACH20057690//RAC-BETA SERINE/THREONINE KINASE (EC 2.7.1.-) (RAC-PK-BETA) (AKT2 KINASE).//8.80E-22//48aa//100%//P31751
  • TRACH20060150
  • TRACH20067620//N-ACETYLLACTOSAMINIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE (EC 2.4.1.150) (N-ACETYLGLUCOSAMINYLTRANSFERASE) (1-BRANCHING ENZYME) (IGNT).//8.20E-76//145aa//92%//Q06430
  • TRACH20068660//Mouse 19.5 mRNA, complete cds.//1.00E-55//263aa//41%//M32486
  • TRACH20068700//Homo sapiens adaptor protein CIKS mRNA, complete cds.//1.50E-232//572aa//79%//AF272151
  • TRACH20069180//Homo sapiens IGHG3 gene for immunoglobulin heavy chain gamma 3 constant region, 4-exon hinge, isolate Lib-A2.//1.00E-213//377aa//100%//AJ390247
  • TRACH20076740//FOLATE-LIKE TRANSPORTER DJ206D15.1 ON CHROMOSOME 1 (FRAGMENT).//1.00E-61//276aa//46%//060779
  • TRACH20076760
  • TRACH20077540//DXS8237E PROTEIN (FRAGMENT).//6.00E-96//189aa//95%//P98175
  • TRACH20079690//ZINC FINGER PROTEIN 136.//1.50E-113//368aa//58%//P52737
  • TRACH20082780
  • TRACH20084720//METHIONYL-TRNA SYNTHETASE, MITOCHONDRIAL (EC 6.1.1.10) (METHIONINE-TRNA LIGASE) (METRS).//8.50E-90//525aa//38%//074634
  • TRACH20085400//Mus musculus immunoglobulin scavenger receptor IgSR mRNA, complete cds.//1.30E-89//384aa//47%//AF302046
  • TRACH20085830//CYTOCHROME P450 4A8 (EC 1.14.14.1) (CYPIVA8) (P450-KP1) (P450-PP1).//3.70E-247//508aa//87%//P24464
  • TRACH20091230
  • TRACH20092680
  • TRACH20096610//LAMIN A (70 KDA LAMIN).//1.70E-77//164aa//93%//P02545
  • TRACH20099340
  • TRACH20105870//EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA (EIF-4-GAMMA) (EIF-4G) (EIF4G) (P220).//9.20E-95//204aa//92%//Q04637
  • TRACH20107710
  • TRACH20109650
  • TRACH20111130
  • TRACH20115740
  • TRACH20118940
  • TRACH20121380//REGULATOR OF G-PROTEIN SIGNALING 14 (RGS14) (FRAGMENT).//7.60E-144//308aa//92%//043566
  • TRACH20128110//Rattus norvegicus TM6P1 (TM6P1) mRNA, complete cds.//2.10E-87//187aa//88%//AF186469
  • TRACH20128230//Homo sapiens IGHG3 gene for immunoglobulin heavy chain gamma 3 constant region, 4-exon hinge, isolate Lib-A2.//9.60E-213//377aa//99%//AJ390247
  • TRACH20134950
  • TRACH20135520
  • TRACH20136710//IG LAMBDA CHAIN V-II REGION NIG-84.//2.20E-43//112aa//75%//P04209
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  • UTERU20099720//Homo sapiens mRNA for SPIN protein.//6.50E-72//186aa//79%//Y14946
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Claims (15)

1-14. (canceled)
15. A polynucleotide selected from the group consisting of the following (a) to (g): (a) a polynucleotide comprising a protein-coding region of the nucleotide sequence of any one of SEQ ID NOs: 1 to 2443;
(b) a polynucleotide encoding a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs: 2444 to 4886;
(c) a polynucleotide comprising a nucleotide sequence encoding a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs: 2444 to 4886, wherein, in said amino acid sequence, one or more amino acids have been substituted, deleted, inserted, and/or added, and wherein said nucleotide sequence encodes a polypeptide functionally equivalent to a polypeptide comprising the selected amino acid sequence;
(d) a polynucleotide hybridizing to a polynucleotide comprising the nucleotide sequence of any one of SEQ ID NOs: 1 to 2443, wherein said nucleotide sequence encodes a polypeptide functionally equivalent to a polypeptide encoded by the selected nucleotide sequence;
(e) a polynucleotide comprising a nucleotide sequence encoding a partial amino acid sequence of a polypeptide encoded by the polynucleotide according to any one or (a) to (d); (f) a polynucleotide comprising a nucleotide sequence having at least 70% identity to the nucleotide sequence of any one of SEQ ID Nos: 1 to 2443; and
(g) a polynucleotide comprising sequences having at least 90% identity to the nucleotide sequence of any one of SEQ ID NOs: 1 to 2443.
16. A polypeptide encoded by the polynucleotide of claim 15, or a partial peptide thereof.
17. An antibody binding to the polypeptide or the peptide of claim 16.
18. A method for immunologically assaying the polypeptide or the peptide of claim 16, said method comprising the steps of contacting the polypeptide or the peptide with the antibody binding to said polypeptide or said peptide, and observing the binding between the two.
19. A vector comprising the polynucleotide of claim 15.
20. A transformant carrying the polynucleotide of claim 15 or a vector comprising said polynucleotide.
21. A transformant carrying the polynucleotide of claim 15 or a vector comprising said polynucleotide in an expressible manner.
22. A method for producing a polypeptide or a peptide, said method comprising the steps of culturing the transformant of claim 21 and recovering an expression product.
23. An oligonucleotide comprising at least 15 nucleotides, said oligonucleotide comprising a nucleotide sequence complementary to the nucleotide sequence of any one of SEQ ID NOs: 1 to 2443 or to a complementary strand thereof.
24. A method for synthesizing the polynucleotide of claim 15, said method utilizing an oligonucleotide, which comprises a nucleotide sequence complementary to the nucleotide sequence of any one of SEQ ID NOs 1 to 2443 or to a complementary strand thereof, and comprises at least 15 nucleotides.
25. A method for detecting the polynucleotide of claim 15, said method utilizing an oligonucleotide, which comprises a nucleotide sequence complementary to the nucleotide sequence of any one of SEQ ID NOs: 1 to 2443 or to a complementary strand thereof, and comprises at least 15 nucleotides.
26. An antisense polynucleotide against the polynucleotide of claim 15 or a part thereof.
27. A method for detecting the polynucleotide of claim 15, said method comprising the following steps of:
(a) incubating a target polynucleotide with an oligonucleotice under hybridizable conditions, wherein said oligonucleotide comprises a nucleotide sequence complementary to the nucleotide sequence of any one of SEQ ID NOs: 1 to 2443 or to a complementary strand thereof, and comprises at least 15 nucleotides, and
(b) detecting hybridization of the target polynucleotide with the oligonucleotide.
28. A database of polynucleotides and/or polypeptides, said database comprising information on at least one of the nucleotide sequences of SEQ ID NOs: 1 to 2443 and/or on at least one of the amino acid sequences of SEQ ID NOs: 2444 to 4886.
US11/293,697 2002-03-22 2005-12-05 Novel full-length cDNA Abandoned US20060105376A1 (en)

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