US20060029945A1 - Novel full length cDNA - Google Patents

Novel full length cDNA Download PDF

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Publication number
US20060029945A1
US20060029945A1 US11/072,512 US7251205A US2006029945A1 US 20060029945 A1 US20060029945 A1 US 20060029945A1 US 7251205 A US7251205 A US 7251205A US 2006029945 A1 US2006029945 A1 US 2006029945A1
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Prior art keywords
protein
polynucleotide
polypeptide
nucleotide sequence
clones
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US11/072,512
Inventor
Takao Isogai
Tomoyasu Sugiyama
Tetsuji Otsuki
Ai Wakamatsu
Hiroyuki Sato
Shizuko Ishii
Jun-Ichi Yamamoto
Yuuko Isono
Yuri Hio
Kaoru Otsuka
Keiichi Nagai
Ryotaro Irie
Ichiro Tamechika
Naohiko Seki
Tsutomu Yoshikawa
Motoyuki Otsuka
Kenji Nagahari
Yasuhiko Masuho
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Research Association for Biotechnology
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Research Association for Biotechnology
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Priority to US11/072,512 priority Critical patent/US20060029945A1/en
Publication of US20060029945A1 publication Critical patent/US20060029945A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Definitions

  • the present invention relates to polynucleotides encoding novel polypeptides, polypeptides encoded by the polynucleotides, and new uses of these.
  • the aim of the determination of genomic sequence is to reveal the functions of all genes and their regulation and to understand living organisms as a network of interactions between genes, proteins, cells or individuals through deducing the information in a genome, which is a blueprint of the highly complicated living organisms.
  • To understand living organisms by utilizing the genomic information from various species is not only important as an academic subject, but also socially significant from the viewpoint of industrial application.
  • cDNA which is produced from mRNA that lacks introns, encodes a protein as a single continuous amino acid sequence and allows us to identify the primary structure of the protein easily.
  • ESTs Expression Sequence Tags
  • ESTs The information of ESTs is utilized for analyzing the structure of human genome, or for predicting the exon-regions of genomic sequences or their expression profile.
  • many human ESTs have been derived from proximal regions to the 3′-end of cDNA, and information around the 5′-end of mRNA is extremely little.
  • human cDNAs the number of the corresponding mRNAs whose encoding full-length protein sequences are deduced is approximately 13,000.
  • a novel human full-length cDNA is isolated, it can be used for developing medicines for diseases in which the gene is involved.
  • the protein encoded by the gene can be used as a drug by itself. Thus, it has great significance to obtain a full-length cDNA encoding a novel human protein.
  • human secretory proteins or membrane proteins would be useful by itself as a medicine like tissue plasminogen activator (TPA), or as a target of medicines like membrane receptors.
  • TPA tissue plasminogen activator
  • genes for signal transduction-related proteins (protein kinases, etc.), glycoprotein-related proteins, transcription-related proteins, etc. are genes whose relationships to human diseases have been elucidated.
  • genes for disease-related proteins form a gene group rich in genes whose relationships to human diseases have been elucidated.
  • An objective of the present invention is to provide polynucleotides encoding novel polypeptides, polypeptides encoded by the polynucleotides, and novel usages of these.
  • the inventors have developed a method for efficiently cloning, from a cDNA library having very high fullness-ratio, a human full-length cDNA that is predicted to be a full-length cDNA clone, where the cDNA library is synthesized by an improved method (WO 01/04286) of the oligo-capping method (K. Maruyama and S. Sugano, Gene, 138: 171-174 (1994); Y. Suzuki et al., Gene, 200: 149-156 (1997)). Then, the nucleotide sequences of cDNA clones whose fullness ratio is high, obtained by this method, were determined mainly from their 5′-ends, and, if required, from 3′-ends.
  • the gene expression profiles of cDNA clones whose full-length nucleotide sequence had been determined were studied by analyzing the large-scale cDNA database constructed based on the 5′-end nucleotide sequences of cDNAs obtained.
  • the profiles of gene expression in living cells were also determined by PCR. The present inventors revealed the usefulness of the genes of the present invention based on these analysis results.
  • gene functions were revealed by the analysis of expression profiles in silico based on the information of full-length nucleotide sequences.
  • the expression profiles used in the expression frequency analysis were studied based on the database containing sufficient amount of fragment sequence data.
  • the expression frequency analysis was carried out by referring, for these expression profiles, to the full-length nucleotide sequences of many cDNA clones obtained in the present invention.
  • a highly reliable analysis can be achieved by referring to the full-length nucleotide sequences of a wide variety of genes for the sufficiently large population for analysis (expression profiles).
  • the results of expression frequency analysis using the full-length sequences of the present invention more precisely reflect the gene expression frequency in tissues and cells from which a certain cDNA library was derived.
  • the information of full-length cDNA nucleotide sequence of the present invention made it possible to achieve the highly reliable expression frequency analysis.
  • the full-length cDNA clones of this invention were obtained by the method comprising the steps of [1] preparing libraries containing cDNAs with the high fullness ratio by oligo-capping, and [2] assembling 5′-end sequences and selecting one with the highest probability of completeness in length in the cluster formed (there are many clones longer in the 5′-end direction).
  • the uses of primers designed based on the 5′- and 3′-end sequences of polynucleotides provided by the present invention enable readily obtaining full-length cDNAs without such a special technique.
  • the primer which is designed to be used for obtaining cDNAs capable of being expressed, is not limited to the 5′- and 3′-end sequences of polynucleotide.
  • the present invention relates to a polynucleotide selected from the group consisting of the following (a) to (g):
  • the present invention also relates to a polypeptide encoded by the above-mentioned polynucleotide or a partial peptide thereof, an antibody binding to the polypeptide or the peptide, and a method for immunologically assaying the polypeptide or the peptide, which comprises the steps of contacting the polypeptide or the peptide with the antibody, and observing the binding between the two.
  • the present invention features a vector comprising the above-mentioned polynucleotide, a transformant carrying the polynucleotide or the vector, a transformant carrying the polynucleotide or the vector in an expressible manner, and a method for producing the polypeptide or the peptide, which comprises the steps of culturing the transformant and recovering an expression product.
  • Another feature of the present invention is an oligonucleotide comprising at least 15 nucleotides, said oligonucleotide comprising a nucleotide sequence complementary to the nucleotide sequence of any one of SEQ ID NOs: 1 to 1970 or to a complementary strand thereof.
  • This oligonucleotide can be used as a primer for synthesizing the above-mentioned polynucleotide or used as a probe for detecting the polynucleotide.
  • the present invention includes an antisense polynucleotide against the polynucleotide or a part thereof, and a method for detecting the polynucleotide, which comprises the following steps of:
  • Still another feature of the present invention is a database of polynucleotides and/or polypeptides, said database comprising information on at least one of the nucleotide sequences of SEQ ID NOs: 1 to 1970 and/or on at least one of the amino acid sequences of SEQ ID NOs: 1971 to 3940.
  • polynucleotide is defined as a molecule, such as DNA and RNA, in which multiple nucleotides are polymerized. There are no limitations on the number of the polymerized nucleotides. In case that the polymer contains relatively low number of nucleotides, it is also described as an “oligonucleotide”, which is included in the “polynucleotide” of the present invention.
  • the polynucleotide or the oligonucleotide of the present invention can be a natural or chemically synthesized product. Alternatively, it can be synthesized using a template polynucleotide by an enzymatic reaction such as PCR.
  • the polynucleotide of the present invention may be modified chemically. Moreover, not only a single-strand polynucleotide but also a double-strand polynucleotide is included in the present invention.
  • polynucleotide when the polynucleotide is described merely as “polynucleotide”, it means not only a single-strand polynucleotide but also a double-strand polynucleotide.
  • the nucleotide sequence of only one chain is indicated. However, based on the nucleotide sequence of a sense chain, the nucleotide sequence of the complementary strand thereof is essentially determined.
  • an “isolated polynucleotide” is a polynucleotide the structure of which is not identical to that of any naturally occurring polynucleotide or to that of any fragment of a naturally occurring genomic polynucleotide spanning more than three separate genes.
  • the term therefore includes, for example, (a) a DNA which has the sequence of part of a naturally occurring genomic DNA molecule in the genome of the organism in which it naturally occurs; (b) a polynucleotide incorporated into a vector or into the genomic DNA of a prokaryote or eukaryote in a manner such that the resulting molecule is not identical to any naturally occurring vector or genomic DNA; (c) a separate molecule such as a cDNA, a genomic fragment, a fragment produced by polymerase chain reaction (PCR) or a restriction fragment; and (d) a recombinant nucleotide sequence that is part of a hybrid gene, i.e., a gene encoding a fusion polypeptide.
  • substantially pure protein or polypeptide as used herein in reference to a given protein or polypeptide means that the protein or polypeptide is substantially free from other biological macromolecules.
  • the substantially pure protein or polypeptide is at least 75%, 80%, 85%, 95%, or 99% pure by dry weight. Purity can be measured by any appropriate standard method known in the art, for example, by column chromatography, polyacrylamide gel electrophoresis, or HPLC analysis.
  • All the cDNAs provided by the present invention are full-length cDNAs.
  • the “full-length cDNA” herein means that the cDNA contains the ATG codon, which is the start point of translation therein.
  • the untranslated regions upstream and downstream of the protein-coding region, both of which are naturally contained in natural mRNAs, are not indispensable. It is preferable that the full-length cDNAs of the present invention contain the stop codon.
  • FIG. 1 shows the restriction map of the vector pME18SFL3.
  • All the clones (1970 clones) of the present invention are novel and encode the full-length polypeptides. Further, all the clones are cDNAs with the high fullness ratio, which were obtained by oligo-capping method, and also clones which are not identical to any of known human mRNAs (namely, novel clones) selected by searching, for the 5′-end sequences, mRNA sequences with the annotation of “complete cds” in the GenBank and UniGene databases by using the BLAST homology search [S. F. Altschul, W. Gish, W. Miller, E. W. Myers & D. J. Lipman, J. Mol. Biol., 215: 403-410 (1990); W. Gish & D. J.
  • All the full-length cDNAs of the present invention can be synthesized by a method such as PCR (Current protocols in Molecular Biology edit. Ausubel et al. (1987) Publish. John Wiley & Sons Section 6.1-6.4) using primer sets designed based on the 5′-end and 3′-end sequences or using primer sets of primers designed based on the 5′-end sequences and a primer of oligo dT sequence corresponding to poly A sequence.
  • PCR Current protocols in Molecular Biology edit. Ausubel et al. (1987) Publish. John Wiley & Sons Section 6.1-6.4
  • primer sets designed based on the 5′-end and 3′-end sequences or using primer sets of primers designed based on the 5′-end sequences and a primer of oligo dT sequence corresponding to poly A sequence.
  • Table 1 contains the clone names of full-length cDNA of 1970 clones of the present invention, SEQ ID NOs of the full-length nucleotide sequences, CDS portions deduced from the full-length nucleotide sequences, and SEQ ID NOs of the translated amino acids.
  • the positions of CDS are shown according to the rule of “DDBJ/EMBL/GenBank Feature Table Definition” (http://www.ncbi.nlm.nih.gov/collab/FT/index.html).
  • the start position number corresponds to the first letter of “ATG” that is the nucleotide triplet encoding methionine; the termination position number corresponds to the third letter of the stop codon.
  • BRACE20054480 97 111 . . . 902 2067 BRACE20054600 98 392 . . . 1276 2068 BRACE20055560 99 136 . . . 735 2069 BRACE20057870 100 1169 . . . 1825 2070 BRACE20059110 101 1452 . . . 1910 2071 BRACE20059810 102 689 . . . 2218 2072 BRACE20061620 103 162 . . . 1163 2073 BRACE20062580 104 1164 . . . 1859 2074 BRACE20063540 105 378 . . .
  • BRAMY20083820 180 625 . . . 1113 2150 BRAMY20089770 181 173 . . . 955 2151 BRAMY20091230 182 818 . . . 1579 2152 BRAMY20093490 183 637 . . . 1080 2153 BRAMY20094890 184 30 . . . 2138 2154 BRAMY20095080 185 239 . . . 613 2155 BRAMY20095570 186 109 . . . 807 2156 BRAMY20096930 187 1381 . . . 1800 2157 BRAMY20100680 188 268 . . . 870 2158 BRAMY20102900 189 200 .
  • BRAMY20245760 236 35 . . . 1375 2206 BRAMY20251210 237 68 . . . 955 2207 BRAMY20251750 238 97 . . . 846 2208 BRAMY20263000 239 216 . . . 1553 2209 BRAMY20267780 240 1194 . . . 1706 2210 BRAMY20269040 241 989 . . . 2071 2211 BRAMY20271140 242 1582 . . . 2238 2212 BRAMY20274510 243 1785 . . . 2138 2213 BRAMY20285650 244 23 . . .
  • CTONG20055670 >2955 2317 CTONG20055670 348 2306 . . . 2620 2318 CTONG20055850 349 506 . . . 1246 2319 CTONG20056150 350 95 . . . 1150 2320 CTONG20057750 351 2355 . . . 2849 2321 CTONG20057950 352 3061 . . . 3420 2322 CTONG20059130 353 109 . . . 2613 2323 CTONG20060040 354 204 . . . 2630 2324 CTONG20061290 355 226 . . . 819 2325 CTONG20062730 356 307 . . . 687 2326 CTONG20063770 357 108 . . .
  • CTONG20077760 378 1517 . . . 2170 2348 CTONG20078340 379 100 . . . 2229 2349 CTONG20079590 380 149 . . . 1066 2350 CTONG20080140 381 159 . . . 686 2351 CTONG20081840 382 586 . . . 897 2352 CTONG20083430 383 159 . . . 1325 2353 CTONG20083980 384 106 . . . 1440 2354 CTONG20084020 385 301 . . . 666 2355 CTONG20084660 386 217 . . . 753 2356 CTONG20085210 387 769 . . .
  • CTONG20174290 398 96 . . . 1826 2368 CTONG20174440 399 1246 . . . 1623 2369 CTONG20174580 400 1 . . . 1023 2370 CTONG20176040 401 147 . . . 737 2371 CTONG20179390 402 1423 . . . 1881 2372 CTONG20179890 403 335 . . . 2344 2373 CTONG20179980 404 1821 . . . 2210 2374 CTONG20180620 405 1556 . . . 1915 2375 CTONG20180690 406 366 . . . 1442 2376 CTONG20181350 407 1167 . . .
  • FCBBF20029280 1014 2415 FCBBF20029280 446 1680 . . . 2021 2416 FCBBF20032930 447 90 . . . 452 2417 FCBBF20033360 448 315 . . . 2369 2418 FCBBF20035430 449 196 . . . 726 2419 FCBBF20035490 450 131 . . . 1387 2420 FCBBF20036360 451 16 . . . 366 2421 FCBBF20038230 452 1468 . . . 1908 2422 FCBBF20038950 453 648 . . . 992 2423 FCBBF20041380 454 612 . . .
  • FCBBF30001020 464 16 . . . 348 2434 FCBBF30001100 465 341 . . . >3125 2435 FCBBF30001150 466 1209 . . . 1631 2436 FCBBF30002270 467 319 . . . 927 2437 FCBBF30002280 468 113 . . . 4036 2438 FCBBF30002330 469 6 . . . 611 2439 FCBBF30003610 470 1015 . . . 2019 2440 FCBBF30004340 471 120 . . . 1013 2441 FCBBF30004730 472 368 . . .
  • FCBBF30080730 500 54 . . . 467 2470 FCBBF30081000 501 526 . . . 924 2471 FCBBF30085560 502 60 . . . 1919 2472 FCBBF30088700 503 39 . . . >3015 2473 FCBBF30089380 504 8 . . . 2701 2474 FCBBF30091010 505 172 . . . >3465 2475 FCBBF30091520 506 56 . . . 2284 2476 FCBBF30093170 507 974 . . . 1528 2477 FCBBF30095410 508 64 . . .
  • FCBBF30106950 518 192 . . . 944 2488 FCBBF30107290 519 1002 . . . 1610 2489 FCBBF30107330 520 703 . . . 1071 2490 FCBBF30114180 521 1777 . . . 2289 2491 FCBBF30114850 522 769 . . . 1503 2492 FCBBF30115230 523 417 . . . 755 2493 FCBBF30115920 524 543 . . . 1802 2494 FCBBF30118670 525 891 . . . 2807 2495 FCBBF30118890 526 184 . . .
  • FCBBF30125460 >2630 2496 FCBBF30125460 527 67 . . . 1926 2497 FCBBF30125880 528 185 . . . 670 2498 FCBBF30128420 529 1789 . . . 2130 2499 FCBBF30129010 530 184 . . . 1236 2500 FCBBF30130410 531 1149 . . . 1874 2501 FCBBF30130580 532 156 . . . 2123 2502 FCBBF30132050 533 718 . . . 1854 2503 FCBBF30132660 534 86 . . . 1051 2504 FCBBF30135890 535 214 . . .
  • FCBBF30136230 536 24 . . . 3338 2506 FCBBF30138000 537 646 . . . 2901 2507 FCBBF30142290 538 679 . . . 1662 2508 FCBBF30143550 539 111 . . . 3191 2509 FCBBF30145670 540 1533 . . . 1880 2510 FCBBF30151190 541 974 . . . 1312 2511 FCBBF30153170 542 16 . . . 2307 2512 FCBBF30157270 543 84 . . . >3303 2513 FCBBF30161780 544 21 . . .
  • FCBBF30164510 545 561 . . . 3035 2515 FCBBF30166220 546 178 . . . 483 2516 FCBBF30169280 547 116 . . . 901 2517 FCBBF30169870 548 102 . . . 407 2518 FCBBF30170710 549 8 . . . 382 2519 FCBBF30171230 550 1735 . . . 2361 2520 FCBBF30172330 551 2497 . . . 2952 2521 FCBBF30173960 552 106 . . . >3530 2522 FCBBF30175350 553 2 . . .
  • FCBBF30263080 581 535 . . . 900 2551 FCBBF30266510 582 445 . . . 3378 2552 FCBBF30271990 583 187 . . . 1704 2553 FCBBF30275590 584 51 . . . >2374 2554 FCBBF30282020 585 123 . . . 1721 2555 FCBBF30285930 586 260 . . . 697 2556 FCBBF30287940 587 1636 . . . 2079 2557 FCBBF40000610 588 586 . . . 1131 2558 FCBBF40001920 589 753 . . .
  • FCBBF40005000 590 57 . . . 446 2560 FCBBF50000410 591 930 . . . 1256 2561 FCBBF50000610 592 383 . . . 697 2562 FCBBF50001650 593 562 . . . 1815 2563 FCBBF50003530 594 127 . . . 921 2564 FCBBF50004950 595 2156 . . . 2545 2565 FEBRA20005040 596 295 . . . 2100 2566 FEBRA20007820 597 160 . . . 690 2567 FEBRA20018670 598 184 . . .
  • HLUNG20032460 709 29 . . . 1582 2679 HLUNG20033060 710 1085 . . . >2287 2680 HLUNG20033310 711 1319 . . . 1654 2681 HLUNG20033350 712 1035 . . . >2205 2682 HLUNG20034970 713 1046 . . . 1747 2683 HLUNG20037140 714 1342 . . . 1698 2684 HLUNG20037160 715 1704 . . . 3152 2685 HLUNG20037780 716 1190 . . . 1855 2686 HLUNG20038330 717 433 . . .
  • KIDNE20083150 763 863 . . . 1342 2733 KIDNE20083620 764 216 . . . 1142 2734 KIDNE20084030 765 28 . . . 1572 2735 KIDNE20084040 766 318 . . . 926 2736 KIDNE20084730 767 580 . . . 2511 2737 KIDNE20084800 768 9 . . . 332 2738 KIDNE20086490 769 162 . . . 1919 2739 KIDNE20086660 770 341 . . . 700 2740 KIDNE20086970 771 202 . . . 846 2741 KIDNE20087880 772 668 .
  • KIDNE20160960 801 10 . . . 534 2771 KIDNE20163710 802 1605 . . . 1973 2772 KIDNE20165390 803 68 . . . 2341 2773 KIDNE20169180 804 125 . . . 2146 2774 KIDNE20170400 805 597 . . . 2192 2775 KIDNE20173150 806 51 . . . 1052 2776 KIDNE20173430 807 136 . . . 1296 2777 KIDNE20176030 808 2418 . . . 2879 2778 KIDNE20181670 809 180 . . .
  • KIDNE20182540 810 135 . . . 1745 2780
  • KIDNE20186170 811 83 . . . 748
  • KIDNE20188630 812 519 . . . 926
  • KIDNE20189890 813 1834 . . . 2445
  • KIDNE20189960 814 284 . . . 1666 2784 KIDNE20191870 815 860 . . . 1372
  • LIVER20006260 816 379 . . . 1668
  • LIVER20007690 817 329 . . . 760
  • LIVER20007750 818 176 . . . 1549
  • LIVER20010510 819 757 .
  • MESAN20026870 840 63 . . . 2450 2810 MESAN20027240 841 39 . . . 1940 2811 MESAN20027900 842 212 . . . 3322 2812 MESAN20029780 843 1900 . . . 2331 2813 MESAN20030350 844 142 . . . >2239 2814 MESAN20030370 845 735 . . . 2462 2815 MESAN20030390 846 3 . . . 389 2816 MESAN20033220 847 68 . . . 478 2817 MESAN20034440 848 42 . . . 2183 2818 MESAN20038520 849 31 . . .
  • PLACE60064180 1061 167 . . . 1240 3031 PLACE60064740 1062 302 . . . 952 3032 PLACE60066970 1063 697 . . . 1998
  • PLACE60068710 1064 363 . . . 1139
  • PLACE60069880 1065 898 . . . 1374
  • PLACE60070500 1066 765 . . . 1718
  • PLACE60071800 1067 689 . . . 1333 3037
  • PLACE60072390 1068 145 . . . 522 3038 PLACE60072420 1069 289 . . . 684
  • PLACE60073090 1070 384 3040
  • PLACE60120280 1091 61 . . . 705
  • PLACE60122970 1092 861 . . . >1396
  • PLACE60132200 1093 240 . . . 1082
  • PLACE60132320 1094 471 . . . 1121
  • PLACE60132880 1095 495 . . . 1406
  • PLACE60140640 1097 840 . . . 1919
  • PLACE60150510 1098 215 . . . 1246
  • PLACE60154450 1099 25 . . . 873
  • PLACE60157310 1101 1156 . . . 1482 3071 PLACE60162100 1102 885 . . . 1226 3072 PLACE60175640 1103 242 . . . 556 3073 PLACE60177880 1104 104 . . . 1327 3074 PLACE60177910 1105 59 . . . 442 3075 PLACE60181870 1106 131 . . . 673 3076 PLACE60184410 1107 995 . . . 1483 3077 PLACE60184870 1108 86 . . . >1402 3078 PLACE60188630 1109 571 . . .
  • PROST20097840 1160 687 . . . 1289 3130 PROST20099090 1161 85 . . . 792 3131 PROST20102190 1162 86 . . . 406 3132 PROST20102500 1163 1467 . . . 2051 3133 PROST20103820 1164 1770 . . . 2078 3134 PROST20105450 1165 1027 . . . 1911 3135 PROST20106060 1166 97 . . . 705 3136 PROST20108850 1167 1173 . . . 1664 3137 PROST20110120 1168 804 . . . 1139 3138 PROST20114100 1169 74 . . .
  • PROST20152510 1180 1095 . . . 2168 3150 PROST20152870 1181 258 . . . 1322 3151 PROST20155370 1182 606 . . . 2255 3152 PROST20156360 1183 1557 . . . 1898 3153 PROST20159320 1184 67 . . . 567 3154 PROST20168600 1185 336 . . . 1700 3155 PUAEN10000650 1186 341 . . . 943 3156 PUAEN10000870 1187 1676 . . . 2029 3157 PUAEN10001640 1188 332 . . . 1138 3158 PUAEN20000800 1189 327 . .
  • SPLEN20195710 1380 64 . . . 516 3350 SPLEN20197090 1381 11 . . . 550 3351 SPLEN20197740 1382 2 . . . 499 3352 SPLEN20197930 1383 803 . . . >1625 3353 SPLEN20198390 1384 14 . . . 1873 3354 SPLEN20199850 1385 575 . . . 1009 3355 SPLEN20200070 1386 353 . . . 655 3356 SPLEN20200340 1387 1047 . . . 1814 3357 SPLEN20201830 1388 143 . . . 1177 3358 SPLEN20203590 1389 160 .
  • TESTI20057840 1455 180 . . . 1271 3425 TESTI20057880 1456 39 . . . 1697 3426 TESTI20058350 1457 25 . . . 1368 3427 TESTI20058920 1458 108 . . . 1088 3428 TESTI20059080 1459 2134 . . . 3069 3429 TESTI20059330 1460 540 . . . 845 3430 TESTI20059370 1461 655 . . . 1137 3431 TESTI20059480 1462 52 . . . 1362 3432 TESTI20059790 1463 203 . . .
  • TESTI20107340 1536 1229 . . . 1723 3506 TESTI20108060 1537 371 . . . 925 3507 TESTI20112540 1538 148 . . . 1554 3508 TESTI20112860 1539 285 . . . 1829 3509 TESTI20113150 1540 374 . . . 1042 3510 TESTI20113940 1541 1185 . . . 1598 3511 TESTI20114480 1542 161 . . . 2032 3512 TESTI20116050 1543 218 . . . 1756 3513 TESTI20116120 1544 17 . . .
  • TESTI20125440 1555 342 . . . 671 3525 TESTI20125920 1556 31 . . . 1680 3526 TESTI20126280 1557 169 . . . 2562 3527 TESTI20130530 1558 298 . . . 1692 3528 TESTI20131440 1559 223 . . . 1278 3529 TESTI20132310 1560 204 . . . 713 3530 TESTI20132680 1561 1011 . . . 1448 3531 TESTI20134010 1562 334 . . . 1464 3532 TESTI20134270 1563 59 . . .
  • THYMU20073080 1782 755 . . . 1198 3752 THYMU20077250 1783 645 . . . 1241
  • THYMU20078020 1784 1290 . . . 1598 3754
  • THYMU20078240 1785 1506 . . . 1838
  • THYMU20079690 1786 1049 . . . 1714 3756
  • THYMU20187210 1847 190 . . . 507 3817 THYMU20191970 1848 230 . . . 1597 3818 TKIDN10000620 1849 1075 . . . 1419 3819 TKIDN10001710 1850 1685 . . . 2365 3820 TKIDN10001920 1851 98 . . . 793 3821 TRACH20011010 1852 228 . . . 2033 3822 TRACH20011540 1853 125 . . . 478 3823 TRACH20012490 1854 83 . . . 1600 3824 TRACH20021000 1855 234 . . .
  • TRACH20164100 1896 372 . . . 722 3866 TRACH20164810 1897 1685 . . . 2104 3867 TRACH20165330 1898 704 . . . 1102 3868 TRACH20165540 1899 810 . . . 1514 3869 TRACH20167090 1900 57 . . . 1148 3870 TRACH20170860 1901 186 . . . 1625 3871 TRACH20173680 1902 83 . . . 1597 3872 TRACH20174980 1903 93 . . . 1088 3873 TRACH20182780 1904 1669 . . . 2070 3874 TRACH20185120 1905 13 . . .
  • primers used to synthesize polynucleotides can be designed based on the nucleotide sequences of polynucleotides of the present invention shown in SEQ ID NOs in the above Table 1.
  • an oligo dT primer can be used as the 3′-end primer.
  • the length of the primers is usually 15-100 bp, and favorably between 15-35 bp. In case of LA PCR, which is described below, the primer length of 25-35 bp may provide a good result.
  • a method to design a primer that enables a specific amplification based on the aimed nucleotide sequence is known to those skilled in the art (Current Protocols in Molecular Biology, Ausubel et al. edit, (1987) John Wiley & Sons, Section 6.1-6.4).
  • the primer is designed so as that, in principle, the amplification products will include the translation start site. Accordingly, for example, when the 5′-end primer is designed based on the nucleotide sequence of 5′ untranslated region (5′UTR), any part of the 5′-end, which ensures the specificity to the cDNA of interest, can be selected as the primer.
  • the target nucleotide sequence to be amplified can extend to several thousand bp in some cDNA.
  • LA PCR Long and Accurate PCR
  • LA PCR in which a special DNA polymerase having 3′->5′ exonuclease activity is used, misincorporated nucleotides can be removed. Accordingly, accurate synthesis of the complementary strand can be achieved even with a long nucleotide sequence.
  • a template DNA for synthesizing the full-length cDNA of the present invention can be obtained by using cDNA libraries that are prepared by various methods.
  • the full-length cDNA clones of the present invention are clones with high probability of completeness in length, which were obtained by the method comprising the steps of [1] preparing libraries containing cDNAs with the very high fullness ratio by oligo-capping, and [2] assembling the 5′-end sequences and selecting one with the highest probability of completeness in length in the cluster formed (there are many clones longer in the 5′-end direction).
  • primers designed based on the full-length nucleotide sequences provided by the present invention enable easily obtaining full-length cDNAs without such a special technique.
  • the problem with the cDNA libraries prepared by the known methods or commercially available is that mRNA contained in the libraries has very low fullness ratio. Thus, it is difficult to screen full-length cDNA clone directly from the library using ordinary cloning methods.
  • the present invention has revealed a nucleotide sequence of novel full-length cDNA. If a full-length nucleotide sequence is provided, it is possible to synthesize a target full-length cDNA by using enzymatic reactions such as PCR. In particular, a full-length-enriched cDNA library, synthesized by methods such as oligo-capping, is desirable to synthesize a full-length cDNA with more reliability.
  • the 5′-end sequence of the full-length cDNA clones of the invention can be used to isolate the regulatory element of transcription including the promoter on the genome.
  • a rough draft of the human genome analysis of human genomic sequence with lower accuracy
  • analysis of the entire human genomic sequence is going to be finished.
  • the polypeptide encoded by the full-length cDNA of the invention can be prepared as a recombinant polypeptide or as a natural polypeptide.
  • the recombinant polypeptide can be prepared by inserting the polynucleotide encoding the polypeptide of the invention into a vector, introducing the vector into an appropriate host cell and purifying the polypeptide expressed within the transformed host cell, as described below.
  • the natural polypeptide can be prepared, for example, by utilizing an affinity column to which an antibody against the polypeptide of the invention (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 16.1-16.19) is attached.
  • the antibody used for affinity purification may be either a polyclonal antibody, or a monoclonal antibody.
  • in vitro translation See, for example, “On the fidelity of mRNA translation in the nuclease-treated rabbit reticulocyte lysate system.” Dasso M. C., and Jackson R. J. (1989) Nucleic Acids Res. 17: 3129-3144) may be used for preparing the polypeptide of the invention.
  • Polypeptides functionally equivalent to the polypeptides of the present invention can be prepared based on the activities, which were clarified in the above-mentioned manner, of the polypeptides of the present invention. Using the biological activity possessed by the polypeptide of the invention as an index, it is possible to verify whether or not a particular polypeptide is functionally equivalent to the polypeptide of the invention by examining whether or not the polypeptide has said activity.
  • Polypeptides functionally equivalent to the polypeptides of the present invention can be prepared by those skilled in the art, for example, by using a method for introducing mutations into an amino acid sequence of a polypeptide (for example, site-directed mutagenesis (Current Protocols in Molecular Biology, edit, Ausubel et al., (1987) John Wiley & Sons, Section 8.1-8.5) Besides, such polypeptides can be generated by spontaneous mutations.
  • the present invention also includes a polypeptide comprising the amino acid sequence shown in Table 1 in which one or more amino acids are substituted, deleted, inserted, and/or added, as long as the polypeptides have the equivalent functions to those of the polypeptides identified in the present Examples described later.
  • substitution of one or more amino acids includes substitution of several amino acids.
  • severeal amino acids means, for example, 5 amino acids, preferably 4 or 3 amino acids, more preferably 2 amino acids, and further preferably 1 amino acid.
  • a substituted amino acid has a similar property to that of the original amino acid.
  • Ala, Val, Leu, Ile, Pro, Met, Phe and Trp are assumed to have similar properties to one another because they are all classified into a group of non-polar amino acids.
  • substitution can be performed among non-charged amino acid such as Gly, Ser, Thr, Cys, Tyr, Asn, and Gln, acidic amino acids such as Asp and Glu, and basic amino acids such as Lys, Arg, and His.
  • polypeptides functionally equivalent to the polypeptides of the present invention can be isolated by using techniques of hybridization or gene amplification known to those skilled in the art. Specifically, using the hybridization technique (Current Protocols in Molecular Biology, edit, Ausubel et al., (1987) John Wiley & Sons, Section 6.3-6.4)), those skilled in the art can usually isolate a polynucleotide highly homologous to the polynucleotide encoding the polypeptide identified in the present Example based on the identified nucleotide sequence (Table 1) or a portion thereof and obtain the functionally equivalent polypeptide from the isolated polynucleotide.
  • the present invention include polypeptides encoded by the polynucleotides hybridizing with the polynucleotides encoding the polypeptides identified in the present Example, as long as the polypeptides are functionally equivalent to the polypeptides identified in the present Example.
  • Organisms from which the functionally equivalent polypeptides are isolated are illustrated by vertebrates such as human, mouse, rat, rabbit, pig and bovine, but are not limited to these animals.
  • Washing conditions of hybridization for the isolation of polynucleotides encoding the functionally equivalent polypeptides are usually “1 ⁇ SSC, 0.1% SDS, 37° C.”; more stringent conditions are “0.5 ⁇ SSC, 0.1% SDS, 42° C.”; and still more stringent conditions are “0.1 ⁇ SSC, 0.1% SDS, 65° C.”.
  • the following conditions can be given as hybridization conditions of the present invention. Namely, conditions in which the hybridization is done at “6 ⁇ SSC, 40% Formamide, 25° C.”, and the washing at “1 ⁇ SSC, 55° C.” can be given.
  • More preferable conditions are those in which the hybridization is done at “6 ⁇ SSC, 40% Formamide, 37° C.”, and the washing at “0.2 ⁇ SSC, 55° C.”. Even more preferable are those in which the hybridization is done at “6 ⁇ SSC, 50% Formamide, 37° C.”, and the washing at “0.1 ⁇ SSC, 62° C.”.
  • the more stringent the conditions of hybridization are the more frequently the polynucleotides highly homologous to the probe sequence are isolated. Therefore, it is preferable to conduct hybridization under stringent conditions.
  • stringent conditions in the present invention are, washing conditions of “0.5 ⁇ SSC, 0.1% SDS, 42° C.”, or alternatively, hybridization conditions of “6 ⁇ SSC, 40% Formamide, 37° C.”, and the washing at “0.2 ⁇ SSC, 55° C.”.
  • One skilled in the art can suitably select various conditions, such as dilution ratios of SSC, formamide concentrations, and temperatures to accomplish a similar stringency.
  • the amino acid sequences of polypeptides isolated by using the hybridization techniques usually have high identity to those of the polypeptides of the present invention, which are shown in Table 1.
  • the present invention encompasses a polynucleotide comprising a nucleotide sequence that has a high identity to the nucleotide sequence of claim 1 (a).
  • the present invention encompasses a peptide, or polypeptide comprising an amino acid sequence that has a high identity to the amino acid sequence encoded by the polynucleotide of claim 1 (b).
  • the term “high identity” indicates sequence identity of at least 40% or more; preferably 60% or more; and more preferably 70% or more. Alternatively, more preferable is identity of 90% or more, or 93% or more, or 95% or more, furthermore, 97% or more, or 99% or more.
  • the identity can be determined by using the BLAST search algorithm.
  • the present invention also provides a polynucleotide containing at least 15 nucleotides complementary to a polynucleotide comprising a nucleotide sequence of SEQ ID NOs shown in Table 1 or the complementary strand thereof.
  • complementary strand is defined as one strand of a double strand DNA composed of A:T and G:C base pair to the other strand.
  • complementary is defined as not only those completely matching within a continuous region of at least 15 nucleotides, but also having a identity of at least 70%, favorably 80% or higher, more favorably 90% or higher, and most favorably 95% or higher within that region. The identity may be determined using the algorithm described herein.
  • Such a polynucleotide includes probes and primers used for the detection and amplification of a polynucleotide encoding the inventive polypeptide.
  • the polynucleotide When used as a primer, the polynucleotide usually comprises 15 to 100 bp, and preferably of 15 to 35 bp.
  • the polynucleotide When used as a probe, the polynucleotide comprises the whole or a part of the sequence of a polynucleotide of the invention, and comprises at least 15 bp.
  • primers such polynucleotides are complementary at the 3′-end, and restriction enzyme recognition sequences or tags can be added to the 5′-end.
  • polynucleotides of the present invention include an antisense polynucleotide for suppressing the expression of a polypeptide of the invention, which comprises an amino acid sequence of SEQ ID NOs shown in Table 1.
  • an antisense polynucleotide has at least 15 bp or more, for example 50 bp or more, preferably 100 bp or more, and more preferably 500 bp or more, and usually has 3000 bp or less, and preferably 2000 bp or less.
  • Antisense polynucleotides can be used in the gene therapy of diseases caused by abnormalities of the polypeptides of the invention (abnormal function or abnormal expression).
  • An antisense polynucleotide can be prepared, for example, by the phosphorothioate method (“Physicochemical properties of phosphorothioate oligodeoxynucleotides.” Stein (1988) Nucleic Acids Res. 16: 3209-3221) based on the sequence information of polynucleotide encoding a polypeptide of the invention (for example, the nucleotide sequences of SEQ ID NO: 1 to 1970).
  • the polynucleotides or antisense polynucleotides of the present invention can be used in, for example, gene therapy.
  • target diseases for example, cancers or various inflammatory diseases may be preferable.
  • These molecules can be used for gene therapy, for example, by administrating them to patients by the in vivo or ex vivo method using virus vectors such as retrovirus vectors, adenovirus vectors, and adeno-related virus vectors, or non-virus vectors such as liposomes.
  • the present invention also includes a partial peptide of the polypeptides of the invention.
  • the partial peptide comprises a polypeptide generated as a result that a signal peptide has been removed from a secretory protein. If the polypeptide of the present invention has an activity as a receptor or a ligand, the partial peptide may function as a competitive inhibitor of the polypeptide and may bind to the receptor (or ligand).
  • the present invention includes an antigen peptide for raising antibodies.
  • the peptides comprise at least 7 amino acids, preferably 8 amino acids or more, more preferably 9 amino acids or more, and even more preferably 10 amino acids or more.
  • the peptide can be used for preparing antibodies against the polypeptide of the invention, or competitive inhibitors of them, and also screening for a receptor that binds to the polypeptide of the invention.
  • the partial peptides of the invention can be produced, for example, by genetic engineering methods, known methods for synthesizing peptides, or digesting the polypeptide of the invention with an appropriate peptidase.
  • the present invention also relates to a vector into which a polynucleotide of the invention is inserted.
  • the vector of the invention is not limited as long as it contains the inserted polynucleotide stably.
  • vectors such as pBluescript vector (Stratagene) are preferable as a cloning vector.
  • expression vectors are especially useful. Any expression vector can be used as long as it is capable of expressing the polypeptide in vitro, in E. coli , in cultured cells, or in vivo.
  • pBEST vector Promega
  • pET vector Invitrogen
  • ligation utilizing restriction sites can be performed according to the standard method (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.4-11.11).
  • GATEWAYTM is an expression vector construction system for polypeptide expression
  • This system includes two types of site-specific recombinases (BP CLONASETM and LR CLONASETM) derived from lambda phage and uses BP CLONASETM-specific recombination sites for an Entry Vector and LR CLONASETM-specific recombination sites for a Destination Vector, which may comprise a tag useful for polypeptide purification.
  • BP CLONASETM and LR CLONASETM site-specific recombinases
  • a polynucleotide fragment of interest is inserted into the entry vector using the first recombination. Then, the secondary recombination is allowed to take place between the entry vector, where the polynucleotide fragment of interest has been inserted, and the destination vector.
  • the expression vector can be prepared rapidly and highly efficiently.
  • the step of expression vector construction and expression of polypeptide of interest takes about 7 to 10 days.
  • the polypeptide of interest can be expressed and prepared in only 3 to 4 days. Thus, the system ensures a high-throughput functional analysis for expressed polypeptides (http://biotech.nikkeibp.co.jp/netlink/lto/gateway/).
  • the present invention also relates to a transformant carrying the vector of the invention.
  • Any cell can be used as a host into which the vector of the invention is inserted, and various kinds of host cells can be used depending on the purposes.
  • COS cells or CHO cells can be used, for example.
  • Introduction of the vector into host cells can be performed, for example, by calcium phosphate precipitation method, electroporation method (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 9.1-9.9), lipofectamine method (GIBCO-BRL), or microinjection method, etc.
  • a polynucleotide containing at least 15 nucleotides comprising a nucleotide sequence of any one of the polynucleotides comprising the nucleotide sequences of SEQ ID NOs shown in Table 1 or the complementary strand thereof can be used not only as a primer for synthesizing full-length cDNAs but also for testing and diagnosing the abnormalities of the polypeptide encoded by the full-length cDNA of the present invention.
  • polymerase chain reaction genomic DNA-PCR, or RT-PCR
  • the obtained genomic region can be used for detection and/or diagnosis of the abnormality of the sequence by RFLP analysis, SSCP, or sequencing.
  • analysis of the amount of expression of the mRNA using the polynucleotide of the present invention as a probe or a primer enables detection and diagnosis of the disease.
  • the present invention also relates to antibodies that bind to the polypeptide of the invention.
  • antibodies that bind to the polypeptide of the invention There are no limitations in the form of the antibodies of the invention. They include polyclonal antibodies, monoclonal antibodies, or their portions that can bind to an antigen. They also include antibodies of all classes. Furthermore, special antibodies such as humanized antibodies and chimeric antibodies are also included.
  • the polyclonal antibody of the invention can be obtained according to the standard method by synthesizing an oligopeptide corresponding to the amino acid sequence and immunizing rabbits with the peptide (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.12-11.13).
  • the monoclonal antibody of the invention can be obtained according to the standard method by purifying the polypeptide expressed in E. coli , immunizing mice with the polypeptide, and producing a hybridoma cell by fusing the spleen cells and myeloma cells (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.4-11.11).
  • the antibody binding to the polypeptide of the present invention can be used for purification of the polypeptide of the invention, and also for detection and/or diagnosis of the abnormalities of the expression and structure of the polypeptide.
  • polypeptides can be extracted, for example, from tissues, blood, or cells, and the polypeptide of the invention is detected by Western blotting, immunoprecipitation, or ELISA, etc. for the above purpose.
  • the antibody binding to the polypeptide of the present invention can be utilized for treating the diseases that associates with the polypeptide of the invention.
  • human antibodies, humanized antibodies, or chimeric antibodies are preferable in terms of their low antigenicity.
  • the human antibodies can be prepared by immunizing a mouse whose immune system is replaced with that of human (e.g., see “Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice” Mendez, M. J. et al. (1997) Nat. Genet. 15: 146-156).
  • the humanized antibodies can be prepared by recombination of the hypervariable region of a monoclonal antibody (Methods in Enzymology (1991) 203: 99-121).
  • a cDNA of the present invention encodes, for example, an amino acid sequence of a protein that is predicted to have the following function.
  • the use of the amino acid sequences of the polypeptides encoded by the cDNAs of the present invention enables predicting that the polypeptides have the following functions. It can be predict, from the results of homology search of SwissProt, GenBank, UniGene, or nr, that these polypeptides have such functions.
  • the functions of the polypeptides encoded by the cDNAs of the present invention can be predicted by assessing the presence of signal sequence, transmembrane region, nuclear translocation signal, glycosylation signal, phosphorylation site, and zinc finger motif, SH3 domain, etc. in the amino acid sequences.
  • Biochemistry 33: 3038-3049 can be used to predict the existence of the signal sequence or transmembrane region.
  • a partial amino acid sequence of the polypeptide is fused with another polypeptide such as GFP, the fusion polypeptide is transfected into cultured cells, and the localization is analyzed to predict the function of the original polypeptide.
  • the functions are often predictable by using partial sequence information (preferably 300 nucleotides or more) instead of the full-length nucleotide sequences.
  • partial sequence information preferably 300 nucleotides or more
  • the result of the prediction by using partial nucleotide sequence does not always agree with the result obtained by using full-length nucleotide sequence, and thus, it is needless to say that the prediction of function is preferably performed based on the full-length nucleotide sequences.
  • GenBank, Swiss-Prot, UniGene and nr databases were searched for homologies of the full-length nucleotide sequences of the 1970 clones (see Example 6).
  • the amino acid sequences deduced from the full-length nucleotide sequences were searched for functional domains by PSORT, SOSUI and Pfam. Prediction of functions of polypeptides encoded by the clones and the categorization thereof were performed based on these results obtained.
  • the categorization was carried out by the following method.
  • the cDNA clones were classified into the above-mentioned 14 functional categories based on the results of annotation-based categorization (using the keywords in the case of Swiss-Prot hit data; using Definition or Reference information in the case of GenBank, UniGene, or nr hit data), and the signal sequence search of the deduced ORFs by PSORT and the transmembrane region search by SOSUI.
  • the following 70 clones presumably belong to the category of nuclear proteins and/or RNA synthesis-related proteins.
  • BRACE20061620 BRACE20200770, BRAMY20013670, CTONG20017490, CTONG20020950, HCHON10000150, MESAN20021470, OCBBF20165910, PROST20155370, PUAEN20002470, TESTI20079220, TESTI20079980, TESTI20166670, TESTI20184760, TESTI20252690, TRACH20040390, UTERU20089620, UTERU20094830, UTERU20169020
  • BNGH420036410, FCBBF30257370 are clones which were predicted to highly possibly belong to the category of secretory protein and/or membrane protein based on the result of domain search by Pfam.
  • the two clones shown above are clones which were predicted to highly possibly belong to the category of glycoprotein-related protein based on the result of domain search by Pfam.
  • the 11 clones shown above are clones which were predicted to highly possibly belong to the category of signal transduction-related protein based on the result of domain search by Pfam.
  • the 18 clones shown above are clones which were predicted to highly possibly belong to the category of transcription-related protein based on the result of domain search by Pfam.
  • the 35 clones shown above are clones which were predicted to highly possibly belong to the category of enzyme and/or metabolism-related protein based on the result of domain search by Pfam.
  • the two clones shown above are clones which were predicted to highly possibly belong to the category of cell division and/or cell proliferation-related protein based on the result of domain search by Pfam.
  • the three clones shown above are clones which were predicted to highly possibly belong to the category of cytoskeleton-related protein based on the result of domain search by Pfam.
  • the two clones shown above are clones which were predicted to highly possibly belong to the category of nuclear protein and/or RNA synthesis-related protein based on the result of domain search by Pfam.
  • the 21 clones shown above are clones which were predicted to highly possibly belong to the category of DNA- and/or RNA-binding protein based on the result of domain search by Pfam.
  • the four clones shown above are clones which were predicted to highly possibly belong to the category of ATP- and/or GTP-binding proteins based on the result of domain search by Pfam.
  • the 205 clones shown below are clones which were unassignable to any of the above-mentioned categories, but have been predicted to have some functions based on homology search using their full-length nucleotide sequences and motif search in their estimated ORFs.
  • a polypeptide does not always belong solely to a single category of the above-described functional categories, and therefore, a polypeptide may belong to any of the predicted functional categories.
  • additional functions can be found for the clones classified into these functional categories by further analyses.
  • polypeptide encoded by clones of the invention contains full-length amino acid sequence, it is possible to analyze its biological activity, and its effect on cellular conditions such as cell proliferation and differentiation by expressing the polypeptide as a recombinant polypeptide using an appropriate expression system, injecting the recombinant into the cell, or raising a specific antibody against the polypeptide.
  • the clone predicted to belong to the category of secretory and/or membrane protein means a clone having hit data with some annotation, such as growth factor, cytokine, hormone, signal, transmembrane, membrane, extracellular matrix, receptor, G-protein coupled receptor, ionic channel, voltage-gated channel, calcium channel, cell adhesion, collagen, connective tissue, etc., suggesting that it was a secretory or membrane protein, or a clone in which the presence of nucleotide sequence encoding a signal sequence or transmembrane region was suggested by the results of PSORT and SOSUI analyses for deduced ORF.
  • some annotation such as growth factor, cytokine, hormone, signal, transmembrane, membrane, extracellular matrix, receptor, G-protein coupled receptor, ionic channel, voltage-gated channel, calcium channel, cell adhesion, collagen, connective tissue, etc.
  • the clone predicted to belong to the category of glycoprotein-related protein means a clone having hit data with some annotation, such as glycoprotein, suggesting that the clone encodes a glycoprotein-related protein.
  • the clone predicted to belong to the category of signal transduction-related protein means a clone having hit data with some annotation, such as serine/threonine-protein kinase, tyrosine-protein kinase, SH3 domain, SH2 domain, etc., suggesting that the clone encodes a signal transduction-related protein.
  • the clone predicted to belong to the category of transcription-related protein means a clone having hit data with some annotation, such as transcription regulation, zinc finger, homeobox, etc., suggesting that the clone encodes a transcription-related protein.
  • the clone predicted to belong to the category of disease-related protein means a clone having hit data with some annotation, such as disease mutation, syndrome, etc., suggesting that the clone encodes a disease-related protein, or a clone whose full-length nucleotide sequence has hit data for Swiss-Prot, GenBank, UniGene, or nr, where the hit data corresponds to genes or polypeptides which have been deposited in the Online Mendelian Inheritance in Man (OMIM) (http://www.ncbi.nlm.nih.gov/Omim/), which is the human gene and disease database described later.
  • OMIM Online Mendelian Inheritance in Man
  • the clone predicted to belong to the category of enzyme and/or metabolism-related protein means a clone having hit data with some annotation, such as metabolism, oxidoreductase, E. C. No. (Enzyme commission number), etc., suggesting that the clone encodes an enzyme and/or metabolism-related protein.
  • the clone predicted to belong to the category of cell division and/or cell proliferation-related protein means a clone having hit data with some annotation, such as cell division, cell cycle, mitosis, chromosomal protein, cell growth, apoptosis, etc., suggesting that the clone encodes a cell division and/or cell proliferation-related protein.
  • the clone predicted to belong to the category of cytoskeleton-related protein means a clone having hit data with some annotation, such as structural protein, cytoskeleton, actin-binding, microtubles, etc., suggesting that the clone encodes a cytoskeleton-related protein.
  • the clone predicted to belong to the category of nuclear protein and/or RNA synthesis-related protein means a clone having hit data with some annotation, such as nuclear protein, RNA splicing, RNA processing, RNA helicase, polyadenylation, etc., suggesting that the clone encodes a nuclear protein and/or RNA synthesis-related protein.
  • the clone predicted to belong to the category of protein synthesis and/or transport-related protein means a clone having hit data with some annotation, such as translation regulation, protein biosynthesis, amino-acid biosynthesis, ribosomal protein, protein transport, signal recognition particle, etc., suggesting that the clone encodes a protein synthesis and/or transport-related protein.
  • the clone predicted to belong to the category of cellular defense-related protein means a clone having hit data with some annotation, such as heat shock, DNA repair, DNA damage, etc., suggesting that the clone encodes a cellular defense-related protein.
  • the clone predicted to belong to the category of development and/or differentiation-related proteins means a clone having hit data with some annotation, such as developmental protein, etc., suggesting that the clone encodes a development and/or differentiation-related protein.
  • the clone predicted to belong to the category of DNA- and/or RNA-binding protein means a clone having hit data with some annotation, such as DNA-binding, RNA-binding, etc.
  • the clone predicted to belong to the category of ATP-and/or GTP-binding protein means a clone having hit data with some annotation, such as ATP-binding, GTP-binding, etc.
  • a protein involved in a disease it is possible to perform a functional analysis as described above, but also possible to analyze correlation between the expression or the activity of the protein and a certain disease by using a specific antibody that is obtained by using expressed protein.
  • the database OMIM which is a database of human genes and diseases, to analyze the protein. Further, new information is constantly being deposited in the OMIM database. Therefore, it is possible for one skilled in the art to find a new relationship between a particular disease and a gene of the present invention in the most up-to-date database.
  • the proteins involved in diseases are useful for developing a diagnostic marker or medicines for regulation of their expression and activity, or as a target of gene therapy.
  • nucleotide sequences of cDNAs of the present invention enables analyzing the expression frequency of genes corresponding to the cDNAs.
  • functions of the genes can be predicted based on the information obtained by the expression frequency analysis.
  • BODYMAP there is a database called “BODYMAP”; gene clones are extracted at random from cDNA libraries of various tissues and/or cells, and the clones homologous to one another are assigned to a single cluster based on the information of nucleotide sequence homology at the 3′-end; genes are classified into any clusters, and the numbers of clones in the respective clusters are compared to gain the information on expression frequency (http://bodymap.ims.u-tokyo.ac.jp/).
  • nucleotide sequences of respective clones in this database were categorized (clustered) based on the nucleotide sequence homology determined with a search program; the number of clones belonging to every cluster of each library was determined and normalized; thus, the ratio of a certain gene in a cDNA library was determined.
  • This analysis provided the information of the expression frequency of a gene in a tissue or cell that is the source of the cDNA library.
  • the libraries from the tissues or cells, which had been used in the large-scale cDNA analyses were taken as subjects to compare the expression levels between different tissues or cells. Namely, the expression frequency was analyzed by comparing the previously normalized values between tissues or cells from which 600 or more cDNA clones whose nucleotide sequences had been analyzed were derived. The result of this analysis showed that the cDNA clones corresponded to the genes involved in the pathology and functions, which are indicated below. Each value in Tables 3 to 39 indicated below represents a relative expression frequency; the higher the value, the higher the expression level.
  • Osteoporosis is a pathology in which bones are easily broken owing to overall decrease in components of bone. The onset correlates to the balance between the functions of osteoblast producing bone and osteoclast absorbing bone, namely bone metabolism.
  • the genes involved in the increase of osteoclasts differentiating from precursor cells of monocyte/macrophage line are genes involved in osteoporosis relevant to bone metabolism.
  • a nucleotide sequence information-based analysis was carried out to identify the genes whose expression frequencies are higher or lower in CD34+ cell (cell expressing a glycoprotein CD34) treated with the osteoclast differentiation factor (Molecular Medicine 38. 642-648. (2001)) than in the untreated CD34+ cell, which is the precursor cell of monocyte/macrophage line.
  • the result of comparative analysis for the frequency between the cDNA libraries prepared from the RNA of CD34+ cells (CD34C) and from the RNA of CD34+ cells treated with the osteoclast differentiation factor (D30ST, D60ST or D90ST) showed that the genes whose expression levels were different between the two were 26 clones indicated in Table 3. These clones are involved in osteoporosis.
  • Genes involved in neural cell differentiation are useful for treating neurological diseases. Genes with varying expression levels in response to induction of cellular differentiation in neural cells are thought to be involved in neurological diseases.
  • cancer tissues express a distinct set of genes, and thus the expression thereof can contribute to the carcinogenesis in tissues and cells.
  • genes whose expression patterns in cancer tissues are different from those in normal tissues are cancer-related genes. Search was carried out for the genes whose expression levels in cancer tissues were different from those in normal tissues.
  • genes involved in development and differentiation which is the expression frequency analysis in which the expression levels of genes are compared between developing and/or differentiating tissues and/or cells and adult tissues and/or cells.
  • the genes involved in tissue development and/or differentiation are genes participating in tissue construction and expression of function, and thus are useful genes, which are available for regenerative medicine aiming at convenient regeneration of injured tissues.
  • genes involved in development or differentiation of particular tissues were selected from the 1970 clones whose full-length nucleotide sequence had been revealed (see Example 7).
  • the expression frequency or the like can be analyzed by PCR based on the nucleotide sequences of cDNAs of the present invention.
  • the band intensities can be determined by ethidium bromide staining.
  • the R1 signal or fluorescence intensity can be assayed for the quantity of labeled amplification products.
  • the quantity of amplification products can also be determined by measuring the RI signal or the fluorescence intensity from the RI-labeled or fluorescently labeled probe hybridizing to the products. The assay results thus obtained are compared and then the clones exhibiting differences in the expression levels can be selected.
  • PCR methods There are some quantitative PCR methods: a PCR method using internal standards; a competitive PCR, in which the quantification is achieved by adding, to a sample, a dilution series of a known quantity of a template RNA and by comparing the quantity of an amplification product derived from the RNA of interest with the quantity of an amplification product derived from the template RNA.
  • ATAC-PCR Adaptor-tagged competitive PCR
  • ATAC-PCR is a method of competitive PCR which is practiced by using multiple adapters of different sizes attached to a gene whose 3′-end nucleotide sequence has previously been determined.
  • the ratio of expression frequency of a single mRNA species from a number of tissues (cells) can be assayed in a single step (Nucleic Acids Research 1997, 25 (22): 4694-4696; “DNA Micro-array and Advanced PCR Techniques”, Cell Technology, supplement, Eds., Muramatsu and Nawa (Shujunsha, 2000): 104-112).
  • genes exhibiting tissue-specific expression are genes playing important parts in the tissue functions and, therefore, can be candidates for genes involved in diseases and/or disorders affecting the tissues.
  • inflammation is an important biological response that is known to be involved in various diseases.
  • the representative inflammation-inducing factors include TNF- ⁇ (Tumor Necrosis Factor-alpha).
  • TNF- ⁇ Tumor Necrosis Factor-alpha
  • NF- ⁇ B Tumor Necrosis Factor-alpha
  • IL-2, IL-6 and G-CSF are varied in the expression levels thereof in response to the signal through the pathway.
  • IL-2, IL-6 and G-CSF are varied in the expression levels thereof in response to the signal through the pathway. It is assumed that genes whose expression levels are varied in response to the stimulation of TNF- ⁇ also participate in inflammation.
  • THP-1 cell which is a human monocyte cell line, was cultured in the presence of TNF- ⁇ (Tumor Necrosis Factor-alpha).
  • TNF- ⁇ Tumor Necrosis Factor-alpha
  • the genes whose expression levels were altered owing to the presence of TNF- ⁇ were searched for, and the result showed that the clones whose expression levels were increased owing to the presence of TNF- ⁇ were ASTRO20055530, ASTRO20055930, ASTRO20088950, BRAMY20027390, BRAMY20076130, BRAMY20118410, BRAMY20125360, BRAMY20237190, BRCAN20001480, BRHIP10000720, CD34C20001750, CTONG20078340, CTONG20085210, DFNES20063460, FCBBF20029280, FCBBF20033360, FCBBF30078600, FEBRA20007820, FEBRA20031280, FEBRA20031810, FEBRA20040290, HLUNG200415
  • the clones whose expression levels were decreased owing to the presence of TNF- ⁇ were BNGH420052350, BRACE20052530, BRAMY20003880, CTONG20170940, FCBBF30022680, FCBBF30225930, FCBBF30257370, FEBRA20046280, KIDNE20084030, KIDNE20188630, NT2NE20082130, OCBBF20110210, PLACE60061370, PROST20041460, PROST20075280, PROST20110120, SMINT20006020, TESTI20046540, TESTI20057200, TESTI20113940, TESTI20257910, TESTI20262940, TRACH20149740.
  • These clones are inflammation-related genes.
  • MKN45 which is a gastric cancer cell line
  • HCT20030610 The genes whose expression levels were altered owing to the presence of Helicobacter pylori were searched for, and the result showed that the clones whose expression levels were increased owing to the presence of Helicobacter pylori were BRAMY20028530, BRAMY20035380, OCBBF20170350, PROST20011160, SKMUS20091900, SPLEN20040780, THYMU20078240, TRACH20190460, UTERU20045200, UTERU20064120, ASTRO20055530, CTONG20170940, FEBRA20040290, MESAN20067430, PROST20016760, THYMU10004280, TRACH20090060, UTERU20041970, OCBBF20142290, TESTI20030610.
  • the clones whose expression levels were decreased owing to the presence of Helicobacter pylori were ASTRO20088950, BRACE20052530, BRAMY20003880, BRAMY20027390, BRAMY20036530, BRAMY20118410, BRHIP20000210, FCBBF20032930, FCBBF30022680, FCBBF30169870, FEBRA20182030, KIDNE20182540, LIVER20007750, MESAN20021220, NT2NE20059210, NT2NE20082130, OCBBF20155030, PROST20065100, PROST20075280, SPLEN20110860, TESTI20057200, TESTI20113940, TESTI20149880, TESTI20151800, TESTI20198600, TESTI20257910, THYMU20046770, THYMU20058550, THYMU20150190, FCBBF20033360, FCBBF30257370, FEBRA200980
  • the polypeptide encoded by the cDNA of the present invention is a regulatory factor of cellular conditions such as growth and differentiation
  • it can be used for developing medicines as follows.
  • the polypeptide or antibody provided by the invention is injected into a certain kind of cells by microinjection. Then, using the cells, it is possible to screen low molecular weight compounds, etc. by measuring the change in the cellular conditions, or the activation or inhibition of a particular gene.
  • the screening can be performed as follows.
  • the polypeptide is expressed and purified as recombinant.
  • the purified polypeptide is microinjected into cells such as various cell lines, or primary culture cells, and the cellular change such as growth and differentiation can be examined.
  • the induction of genes whose expression is known to be involved in a particular change of cellular conditions may be detected by the amount of mRNA or polypeptide.
  • the amount of intracellular molecules (low molecular weight compounds, etc.) that is changed by the function of the gene product (polypeptide) which is known to be involved in a particular change of cellular conditions may be detected.
  • the compounds to be screened can be added to the culture media and assessed for their activity by measuring the change of the cellular conditions.
  • cell lines introduced with the gene obtained in the invention can be used for the screening. If the gene product is turn out to be involved in a particular change in the cellular conditions, the change of the product can be used as a measurement for screening. Once a compound is screened out which can activate or inhibit the function of the polypeptide of the invention, it can be applied for developing medicines.
  • polypeptide encoded by the cDNA of the present invention is a secretory protein, membrane protein, or protein involved in signal transduction, glycoprotein, transcription, or diseases, it can be used in functional assays for developing medicines.
  • a membrane protein In case of a membrane protein, it is most likely to be a polypeptide that functions as a receptor or ligand on the cell surface. Therefore, it is possible to reveal a new relationship between a ligand and receptor by screening the membrane protein of the invention based on the binding activity with the known ligand or receptor. Screening can be performed according to the known methods.
  • a ligand against the polypeptide of the invention can be screened in the following manner. Namely, a ligand that binds to a specific polypeptide can be screened by a method comprising the steps of: (a) contacting a test sample with the polypeptide of the invention or a partial peptide thereof, or cells expressing these, and (b) selecting a test sample that binds to said polypeptide, said partial peptide, or said cells.
  • screening using cells expressing the polypeptide of the present invention that is a receptor protein can also be performed as follows. It is possible to screen receptors that is capable of binding to a specific polypeptide by using procedures (a) attaching the sample cells to the polypeptide of the invention or its partial peptide, and (b) selecting cells that can bind to the said polypeptide or its partial peptide.
  • the polypeptide of the invention is expressed, and the recombinant polypeptide is purified.
  • the purified polypeptide is labeled, binding assay is performed using a various cell lines or primary cultured cells, and cells that are expressing a receptor are selected (Growth and differentiation factors and their receptors, Shin-Seikagaku Jikken Kouza Vol. 7 (1991) Honjyo, Arai, Taniguchi, and Muramatsu edit, p203-236, Tokyo-Kagaku-Doujin).
  • a polypeptide of the invention can be labeled with RI such as 125 I, and enzyme (alkaline phosphatase etc.).
  • a polypeptide of the invention may be used without labeling and then detected by using a labeled antibody against the polypeptide.
  • the cells that are selected by the above screening methods, which express a receptor of the polypeptide of the invention, can be used for the further screening of an agonists or antagonists of the said receptor.
  • the receptor of the polypeptide of the invention or the cells expressing the receptor are obtained by screening, it is possible to screen a compound that binds to the ligand and receptor. Also it is possible to screen a compound that can inhibit both bindings (agonists or antagonists of the receptor, for example) by utilizing the binding activities.
  • the screening method comprises the steps of (a) contacting the polypeptide of the invention with its receptor or cells expressing the receptor in the presence of samples, (b) detecting the binding activity between the polypeptide and its receptor or the cells expressing the receptor, and (c) selecting a compound that can potentially reduce the binding activity compared to the activity in the absence of the sample.
  • Samples to screen include cell extracts, expressed products from a gene library, synthesized low molecular compound, synthesized peptide, and natural compounds, for example, but are not construed to be listed here.
  • a compound that is isolated by the above screening using a binding activity of the polypeptide of the invention can also be used as a sample.
  • a compound isolated by the screening may be a candidate to be an agonist or an antagonist of the receptor of the polypeptide.
  • an assay that monitors a change in the intracellular signaling such as phosphorylation which results from reduction of the binding between the polypeptide and its receptor, it is possible to identify whether the obtained compound is an agonist or antagonist of the receptor.
  • the compound may be a candidate of a molecule that can inhibit the interaction between the polypeptide and its associated proteins (including a receptor) in vivo. Such compounds can be used for developing drugs for precaution or cures of a disease in which the polypeptide is involved.
  • Secretory proteins may regulate cellular conditions such as growth and differentiation. It is possible to find out a novel factor that regulates cellular conditions by adding the secretory protein of the invention to a certain kind of cell, and performing a screening by utilizing the cellular changes in growth or differentiation, or activation of a particular gene.
  • the screening can be performed, for example, as follows. First, the polypeptide of the invention is expressed and purified in a recombinant form. Then, the purified polypeptide is added to a various kind of cell lines or primary cultured cells, and the change in the cell growth and differentiation is monitored. The induction of a particular gene that is known to be involved in a certain cellular change is detected by the amounts of mRNA and polypeptide. Alternatively, the amount of an intracellular molecule (low-molecular-weight compounds, etc.) that is changed by the function of a gene product (polypeptide) that is known to function in a certain cellular change is used for the detection.
  • the polypeptide of the invention is expressed and purified in a recombinant form. Then, the purified polypeptide is added to a various kind of cell lines or primary cultured cells, and the change in the cell growth and differentiation is monitored. The induction of a particular gene that is known to be involved in a certain cellular change is detected by the amounts
  • the polypeptide of the invention can regulate cellular conditions or the functions, it is possible to apply the polypeptide as a pharmaceutical and diagnostic medicine for related diseases by itself or by altering a part of it into an appropriate composition.
  • the secretory protein provided by the invention may be used to explore a novel ligand-receptor interaction using a screening based on the binding activity to a known ligand or receptor.
  • a similar method can be used to identify an agonist or antagonist.
  • the resulting compounds obtained by the methods can be a candidate of a compound that can inhibit the interaction between the polypeptide of the invention and an interacting molecule (including a receptor).
  • the compounds may be able to use as a preventive, therapeutic, and diagnostic medicine for the diseases, in which the polypeptide may play a certain role.
  • Proteins involved in signal transduction or transcription may be a factor that affects a certain polypeptide or gene in response to intracellular/extracellular stimuli. It is possible to find out a novel factor that can affect a polypeptide or gene by expressing the polypeptide provided by the invention in a certain types of cells, and performing a screening utilizing the activation of a certain intracellular polypeptide or gene.
  • the screening may be performed as follows. First, a transformed cell line expressing the polypeptide is obtained. Then, the transformed cell line and the untransformed original cell line are compared for the changes in the expression of a certain gene by detecting the amount of its mRNA or polypeptide. Alternatively, the amount of an intracellular molecule (low molecular weight compounds, etc.) that is changed by the function of a certain gene product (polypeptide) may be used for the detection.
  • the change of the expression of a certain gene can be detected by introducing a fusion gene that comprises a regulatory region of the gene and a marker gene (luciferase, ⁇ -galactosidase, etc.) into a cell, expressing the polypeptide provided by the invention into the cell, and estimating the activity of a marker gene product (polypeptide).
  • a marker gene luciferase, ⁇ -galactosidase, etc.
  • polypeptide or gene of the invention is involved in diseases, it is possible to screen a gene or compound that can regulate its expression and/or activity either directly or indirectly by utilizing the polypeptide of the present invention.
  • the polypeptide of the invention is expressed and purified as a recombinant polypeptide. Then, the polypeptide or gene that interacts with the polypeptide of the invention is purified, and screened based on the binding. Alternatively, the screening can be performed by adding with a compound of a candidate of the inhibitor added in advance and monitoring the change of binding activity.
  • a transcription regulatory region locating in the 5′-upstream of the gene encoding the polypeptide of the invention that is capable of regulating the expression of other genes is obtained, and fused with a marker gene. The fusion is introduced into a cell, and the cell is added with compounds to explore a regulatory factor of the expression of the said gene.
  • the compound obtained by the screening can be used for developing pharmaceutical and diagnostic medicines for the diseases in which the polypeptide of the present invention is involved.
  • the regulatory factor obtained in the screening is turn out to be a polypeptide
  • compounds that can newly affect the expression or activity of the polypeptide may be used as a medicine for the diseases in which the polypeptide of the invention is involved.
  • the polypeptide of the invention has an enzymatic activity, regardless as to whether it is a secretory protein, membrane protein, or proteins involved in signal transduction, glycoprotein, transcription, or diseases, a screening may be performed by adding a compound to the polypeptide of the invention and monitoring the change of the compound.
  • the enzymatic activity may also be utilized to screen a compound that can inhibit the activity of the polypeptide.
  • the polypeptide of the invention is expressed and the recombinant polypeptide is purified. Then, compounds are contacted with the purified polypeptide, and the amount of the compound and the reaction products is examined. Alternatively, compounds that are candidates of an inhibitor are pretreated, then a compound (substrate) that can react with the purified polypeptide is added, and the amount of the substrate and the reaction products is examined.
  • the compounds obtained in the screening may be used as a medicine for diseases in which the polypeptide of the invention is involved. Also they can be applied for tests that examine whether the polypeptide of the invention functions normally in vivo.
  • the secretory protein, membrane protein, signal transduction-related protein, glycoprotein-related protein, or transcription-related protein of the present invention is a novel protein involved in diseases or not is determined in another method than described above, by obtaining a specific antibody against the polypeptide of the invention, and examining the relationship between the expression or activity of the polypeptide and a certain disease. In an alternative way, it may be analyzed referred to the methods in “Molecular Diagnosis of Genetic Diseases” (Elles R. edit, (1996) in the series of “Method in Molecular Biology” (Humana Press).
  • Proteins involved in diseases are targets of screening as mentioned, and thus are very useful in developing drugs which regulate their expression and activity. Also, the proteins are useful in the medicinal industry as a diagnostic marker of the related disease or a target of gene therapy.
  • Compounds isolated as mentioned above can be administered patients as it is, or after formulated into a pharmaceutical composition according to the known methods.
  • a pharmaceutically acceptable carrier or vehicle specifically sterilized water, saline, plant oil, emulsifier, or suspending agent can be mixed with the compounds appropriately.
  • the pharmaceutical compositions can be administered to patients by a method known to those skilled in the art, such as intraarterial, intravenous, or subcutaneous injections. The dosage may vary depending on the weight or age of a patient, or the method of administration, but those skilled in the art can choose an appropriate dosage properly.
  • the compound is encoded by polynucleotide, the polynucleotide can be cloned into a vector for gene therapy, and used for gene therapy.
  • the dosage of the polynucleotide and the method of its administration may vary depending on the weight or age of a patient, or the symptoms, but those skilled in the art can choose properly.
  • the present invention further relates to databases comprising at least a sequence of polynucleotide and/or polypeptide, or a medium recorded in such databases, selected from the sequence data of the nucleotide and/or the amino acids indicated in Table 1.
  • database means a set of accumulated information as machine-searchable and readable information of nucleotide sequence.
  • the databases of the present invention comprise at least one of the novel nucleotide sequences of polynucleotides provided by the present invention.
  • the databases of the present invention can consist of only the sequence data of the novel polynucleotides provided by the present invention or can comprise other information on nucleotide sequences of known full-length cDNAs or ESTs.
  • the databases of the present invention can be comprised of not only the information on the nucleotide sequences but also the information on the gene functions revealed by the present invention. Additional information such as names of DNA clones carrying the full-length cDNAs can be recorded or linked together with the sequence data in the databases.
  • the database of the present invention is useful for gaining complete gene sequence information from partial sequence information of a gene of interest.
  • the database of the present invention comprises nucleotide sequence information of full-length cDNAs. Consequently, by comparing the information in this database with the nucleotide sequence of a partial gene fragment yielded by differential display method or subtraction method, the information on the full-length nucleotide sequence of interest can be gained from the sequence of the partial fragment as a starting clue.
  • the sequence information of the full-length cDNAs constituting the database of the present invention contains not only the information on the complete sequences but also extra information on expression frequency of the genes as well as homology of the genes to known genes and known polypeptides. Thus the extra information facilitates rapid functional analyses of partial gene fragments. Further, the information on human genes is accumulated in the database of the present invention, and therefore, the database is useful for isolating a human homologue of a gene originating from other species. The human homologue can be isolated based on the nucleotide sequence of the gene from the original species.
  • gene fragments can be obtained by differential display method and subtraction method.
  • these gene fragments are utilized as tools for isolating the full-length sequences thereof.
  • the full-length sequence is easily obtained by comparing the partial sequence with the information in known databases.
  • cDNA cloning should be carried out for the full-length cDNA. It is often difficult to obtain the full-length nucleotide sequence using the partial sequence information as an initial clue. If the full-length of the gene is not available, the amino acid sequence of the polypeptide encoded by the gene remains unidentified.
  • the database of the present invention can contribute to the identification of full-length cDNAs corresponding to gene fragments, which cannot be revealed by using databases of known genes.
  • the present invention has provided 1970 polynucleotides. As has not yet proceeded the isolation of full-length cDNA within the human, the invention has great significance. It is known that secretory proteins, membrane proteins, signal transduction-related proteins, glycoprotein-related proteins, transcription-related proteins, and so on are involved in many diseases. The genes and proteins involved in diseases are useful for developing a diagnostic marker or medicines for regulation of their expression and activity, or as a target of gene therapy.
  • cDNA assumed to encode secretory proteins which were provided by this invention, are very important for the industry since the encoded proteins themselves are expected to be useful as pharmaceutical agents and many disease-related genes may be included in them.
  • membrane proteins, signal transduction-related proteins, transcription-related proteins, disease-related proteins, and genes encoding them can be used as indicators for diseases, etc.
  • cDNA are also very important for the industry, which are expected to regulate the activity or expression of the encoded protein to treat diseases, etc.
  • RNAs as mRNA sources were extracted from human tissues (shown below) by the method as described in the reference (J. Sambrook, E. F. Fritsch & T. Maniatis, Molecular Cloning Second edition, Cold Spring harbor Laboratory Press, 1989). Further, by the method as described in the reference (J. Sambrook, E. F. Fritsch & T. Maniatis, Molecular Cloning Second edition, Cold Spring harbor Laboratory Press, 1989), total RNAs as mRNA sources were extracted from human culture cells and human primary culture cells (shown below) which had been cultivated by the methods described in the catalogs.
  • the library names and the origins are indicated below in the order of “Library name: Origin”.
  • Library name: Origin When a library was prepared by the subtraction method, the item is followed by a description of how to prepare the subtracted library.
  • RCB indicates that the cell was provided by the Cell Bank, RIKEN GENE BANK, The Institute of Physical and Chemical Research; ATCC indicates that the cell was provided by American Type Culture Collection.
  • RNAs extracted from the following human tissues were purchased and used as mRNA sources.
  • the library names and the origins are indicated below in the order of “Library name: Origin”.
  • RNAs extracted and purified as poly A(+) RNAs from the human tissues shown below were purchased.
  • a cDNA library was prepared from an RNA mixture in which the poly A(+) RNA from each tissue had been combined with poly A( ⁇ ) RNA.
  • the poly A( ⁇ ) RNA was prepared by removing poly A(+) RNA from the total RNA of whole brain tissue (CLONTECH #64020-1) by using oligo dT cellulose.
  • the library names and the origins are indicated below in the order of “Library name: Origin”.
  • cDNA library was prepared from each RNA by the improved method (WO 01/04286) of oligo capping [M. Maruyama and S. Sugano, Gene, 138: 171-174 (1994)].
  • the single-stranded cDNA was converted to a double-stranded cDNA by PCR (polymerase chain reaction) using 5′ (SEQ ID NO: 4095) and 3′ (SEQ ID NO: 4096) PCR primers, and then digested with SfiI. Then, a fraction of cDNA fragments, typically 2-kb or longer (3-kb or longer in some cases), was unidirectionally cloned into a DraIII-digested pME18SFL3 vector ( FIG. 1 ) (GenBank AB009864, Expression vector); the cDNA library was thus prepared.
  • the cDNA library with the high fullness ratio (the fullness ratio of 5′-end, which was calculated for each cDNA library by using the protein coding region found in known mRNA species as an index, was 90% in average) prepared by the improved oligo-capping method was constructed by using a eukaryotic expression vector pME18SFL3.
  • the vector contains SR ⁇ promoter and SV40 small t intron in the upstream of the cloning site, and SV40 polyA added signal sequence site in the downstream.
  • the cloning site of pME18SFL3 has asymmetrical DraIII sites, and the ends of cDNA fragments contain SfiI sites complementary to the DraIII sites, the cloned cDNA fragments can be inserted into the downstream of the SR ⁇ promoter unidirectionally. Therefore, clones containing full-length cDNA can be expressed transiently by introducing the obtained plasmid directly into COS cells, etc. Thus, the clones can be analyzed very easily in terms of the proteins that are the gene products of the clones, or in terms of the biological activities of the proteins.
  • the nucleotide sequences of cDNA 5′-ends (3′-ends as well in some cases) were determined in a DNA sequencer (ABI PRISM 3700, PE Biosystems), after sequencing reaction was conducted by using a DNA sequencing reagent (BigDye Terminator Cycle Sequencing FS Ready Reaction Kit, PE Biosystems) according to the manual.
  • a database was constructed based on the obtained data.
  • the 5′-end completeness of about 770,000 clones derived from the human cDNA libraries prepared by the improved oligo-capping method was determined by the following method.
  • the clones whose 5′-end sequences were consistent with those of known human mRNA in the public database were judged to be “full-length” if they had a longer 5′-end sequence than that of the known human mRNA; or even though the 5′-end sequence was shorter, if it contained the translation initiation codon it was judged to have the “full-length” sequence. Clones which did not contain the translation initiation codon were judged to be “not-full-length”.
  • the fullness ratio ((the number of full-length clones)/(the number of full-length and not-full-length clones)) at the 5′-end of the cDNA clones was determined by comparing with known human mRNA. As a result, the fullness ratio of the 5′-ends was 90%. The result indicates that the fullness ratio at the 5′-end sequence was extremely high in the human cDNA clones obtained by the oligo-capping method.
  • the 5′-end nucleotide sequences of the cDNAs were determined in a DNA sequencer (ABI PRISM 3700, PE Biosystems), after sequencing reaction was conducted by using a DNA sequencing reagent (Dye Terminator Cycle Sequencing FS Ready Reaction Kit, dRhodamine Terminator Cycle Sequencing FS Ready Reaction Kit or BigDye Terminator Cycle Sequencing FS Ready Reaction Kit, PE Biosystems) according to the manual.
  • a database was constructed using the data obtained.
  • the data with the annotation of “complete cds” in the GenBank and UniGene were searched by BLAST homology search. When identical to certain human mRNA sequences, such cDNA clones were excluded. Then, clustering was carried out. When the identity was 90% or higher, and the length of consensus sequence was 50 base pairs or longer, the cDNA clones were assumed to belong to an identical cluster, and thus clustered. cDNA clones longer in the 5′ direction were selected from the members belonging to a cluster; if required, the 31-end sequences of the selected clones were determined by the same analysis method as used to determine the 5′-end sequences.
  • the data of the end sequences obtained were analyzed, and then the clones forming a sequence contig at 5′- and 3′-ends were excluded. Further, as mentioned above, the data was analyzed again by BLAST homology search; when identical to certain human mRNA sequences (including sequences patented and applied for), the cDNA clones were excluded. Thus, the cDNAs clones to be analyzed for their nucleotide sequence were obtained.
  • the full-length nucleotide sequences of the selected clones were determined.
  • the nucleotide sequence determination was mainly performed by primer walking method comprising the dideoxy terminator method using custom-made synthetic DNA primers. Namely, the nucleotide sequences of the DNAs were determined in a sequencer from PE Biosystems, after sequencing reaction was carried out with a DNA sequencing reagent from the same supplier using the custom-made synthetic DNA primers according to the manual. A part of the clones were analyzed with a DNA sequencer from Licor.
  • nucleotide sequences of a part of the clones were determined by the shotgun method where the plasmids containing the cDNAs were digested at random were used, instead of the use of custom-made primers, by the same method in the DNA sequencer.
  • the full-length nucleotide sequences were finally determined by completely assembling the partial nucleotide sequences obtained by the above method.
  • GenBank, SwissProt, UniGene, and nr were searched by BLAST.
  • the clones exhibiting higher homology, which were convenient to predict their functions based on the nucleotide sequences and deduced amino acid sequences, were selected based on the BLAST search hit data whose P value or E value was 10 ⁇ 4 or lower and for which the length of consensus sequence ⁇ homology 30 or higher in the amino acid database search. Further, from them, representative clones were selected, which are shown as Homology Search Result Data in the last part herein. Accordingly, the data shown herein are merely the representative data, and the molecule exhibiting homology to each clone is not limited thereto. Further, with respect to a part of clones, the BLAST search hit data that did not meet the criteria as described above are not shown herein.
  • amino acid sequence in which the signal sequence at the amino terminus or transmembrane domain had been predicted to be present by PSORT or SOSUI were assumed to be a secretory or membrane protein.
  • the protein function can be predicted based on the hit data, for example, by referring to the function categories on the PROSITE (http://www.expasy.ch/cgi-bin/prosite-list.pl).
  • the functional domain search can also be carried out on the PROSITE.
  • the clones whose deduced amino acid sequences were detected to have the signal sequences by PSORT are as follows.
  • the clones whose deduced amino acid sequences were detected to have the transmembrane domains by SOSUI are as follows. Numerals indicate the numbers of transmembrane domains detected in the deduced amino acid sequences. Of the search result, the clone name and the number of transmembrane domains are demarcated by a double slash mark (//).
  • the Names of clones whose deduced amino acid sequences were detected to have functional domains with Pfam, and the name of hit functional domains are as follows.
  • the search result is indicated as “clone name//functional domain name”.
  • the clone has multiple hit functional domains, they are listed and demarcated by a double slash mark (//).
  • the clone has multiple hits of an identical functional domain, each is listed without abridgment.
  • the functional prediction and categorization of the proteins encoded by the clones were carried out based on the result of homology search of the databases of GenBank, Swiss-Prot, UniGene and nr (see the Homology Search Result Data) for the full-length nucleotide sequences and the result of domain search of the amino acid sequences deduced from the full-length nucleotide sequences (see Example 5).
  • the clone predicted to belong to the category of secretory protein/membrane protein means a clone having hit data with some annotation, such as growth factor, cytokine, hormone, signal, transmembrane, membrane, extracellular matrix, receptor, G-protein coupled receptor, ionic channel, voltage-gated channel, calcium channel, cell adhesion, collagen, connective tissue, etc., suggesting that it is a secretory or membrane protein, or means a clone in which the presence of nucleotide sequence encoding a signal sequence or transmembrane domain was suggested by the results of PSORT and SOSUI analyses for deduced ORF.
  • the clone predicted to belong to the category of glycoprotein-related protein means a clone having hit data with some annotation, such as glycoprotein, suggesting that the clone encodes a glycoprotein-related protein.
  • the clone predicted to belong to the category of signal transduction-related protein means a clone having hit data with some annotation, such as serine/threonine-protein kinase, tyrosine-protein kinase, SH3 domain, SH2 domain, etc., suggesting that the clone encodes a signal transduction-related protein.
  • the clone predicted to belong to the category of transcription-related protein means a clone having hit data with some annotation, such as transcription regulation, zinc finger, homeobox, etc., suggesting that the clone encodes a transcription-related protein.
  • the clone predicted to belong to the category of disease-related protein means a clone having hit data with some annotation, such as disease mutation, syndrome, etc., suggesting that the clone encodes a disease-related protein, or means a clone whose full-length nucleotide sequence has hit data for Swiss-Prot, GenBank, or UniGene, where the hit data corresponds to genes or proteins which have been deposited in the Online Mendelian Inheritance in Man (OMIM) (http://www.ncbi.nlm.nih.gov/Omim/), which is the human gene and disease database.
  • OMIM Online Mendelian Inheritance in Man
  • the clone predicted to belong to the category of enzyme and/or metabolism-related protein means a clone having hit data with some annotation, such as metabolism, oxidoreductase, E. C. No. (Enzyme commission number), etc., suggesting that the clone encodes an enzyme and/or metabolism-related protein.
  • the clone predicted to belong to the category of cell division and/or cell proliferation-related protein means a clone having hit data with some annotation, such as cell division, cell cycle, mitosis, chromosomal protein, cell growth, apoptosis, etc., suggesting that the clone encodes a cell division and/or cell proliferation-related protein.
  • the clone predicted to belong to the category of cytoskeleton-related protein means a clone having hit data with some annotation, such as structural protein, cytoskeleton, actin-binding, microtubles, etc., suggesting that the clone encodes a cytoskeleton-related protein.
  • the clone which is predicted to belong to the category of nuclear protein and/or RNA synthesis-related protein means a clone having hit data with some annotation, such as nuclear protein, RNA splicing, RNA processing, RNA helicase, polyadenylation, etc., suggesting that the clone encodes a nuclear protein and/or RNA synthesis-related protein.
  • the clone predicted to belong to the category of protein synthesis and/or transport-related protein means a clone having hit data with some annotation, such as translation regulation, protein biosynthesis, amino-acid biosynthesis, ribosomal protein, protein transport, signal recognition particle, etc., suggesting that the clone encodes a protein synthesis and/or transport-related protein.
  • the clone predicted to belong to the category of cellular defense-related protein means a clone having hit data with some annotation, such as heat shock, DNA repair, DNA damage, etc., suggesting that the clone encodes a cellular defense-related protein.
  • the clone predicted to belong to the category of development and/or differentiation-related proteins means a clone having hit data with some annotation, such as developmental protein, etc., suggesting that the clone encodes a development and/or differentiation-related protein.
  • the clone predicted to belong to the category of DNA-binding and/or RNA-binding protein means a clone having hit data with some annotation, such as DNA-binding, RNA-binding, etc.
  • the clone predicted to belong to the category of ATP-binding and/or GTP-binding protein means a clone having hit data with some annotation, such as ATP-binding, GTP-binding, etc.
  • the clones predicted to belong to the category of secretory protein and/or membrane protein are the following 516 clones.
  • the clones predicted to belong to the category of glycoprotein-related protein are the following 121 clones.
  • the clones predicted to belong to the category of signal transduction-related protein are the following 88 clones.
  • the clones predicted to belong to the category of transcription-related protein are the following 143 clones.
  • the clones predicted to belong to the category of disease-related protein are the following 331 clones.
  • hit data of the following 328 clones for Swiss-Prot, or GenBank, UniGene, or nr corresponded to genes or proteins which had been deposited in the Online Mendelian Inheritance in Man (OMIM), which is the human gene and disease database, (the OMIM Number is shown in the parenthesis after the Clone Name).
  • OMIM Online Mendelian Inheritance in Man
  • ADRGL20020290 (602193), ADRGL20021910 (605717), ADRGL20026790 (605046), ADRGL20036840 (142800), ADRGL20059610 (230800; 230900; 231000; 231005), ADRGL20066770 (130660), ASTRO20038400 (604764), ASTRO20052420 (600888), ASTRO20055570 (176640; 123400; 137440; 245300; 600072), ASTRO20075150 (601896), ASTRO20088950 (603202; 223000; 223100), BNGH420008150 (600050), BNGH420086030 (118423), BRACE10000510 (148021), BRACE20003310 (603899), BRACE20069000 (204200), BRACE20097540 (604908), BRACE20194670 (314375), BRACE20196180 (605535), BRACE20204670 (176884), BRACE20216950 (158070), BRAMY2000
  • the clones predicted to belong to the category of enzyme and/or metabolism-related protein are the following 219 clones.
  • the clones predicted to belong to the category of cell division and/or cell proliferation-related protein are the following 44 clones.
  • the clones predicted to belong to the category of cytoskeleton-related protein are the following 80 clones.
  • the clones predicted to belong to the category of nuclear protein and/or RNA synthesis-related protein are the following 70 clones.
  • the clones predicted to belong to the category of protein synthesis and/or transport-related protein are the following 20 clones.
  • the clones predicted to belong to the category of cellular defense-related protein are the following 10 clones. ASTRO20089600, BRAMY20117670, FEBRA20087550, HLUNG20081390, MESAN20057240, NTONG20031580, PROST20007600, SPLEN20023850, SPLEN20043680, TESTI20261680
  • the clones predicted to belong to the category of development and/or differentiation-related protein are the following 19 clones.
  • the clones predicted to belong to the category of DNA-binding and/or RNA-binding protein are the following 168 clones.
  • the clones predicted to belong to the category of ATP binding and/or GTP-binding protein are the following 93 clones.
  • BNGH420036410 and FCBBF30257370 are clones which were predicted to highly possibly belong to the category of secretory protein and/or membrane protein based on the result of domain search by Pfam.
  • the two clones shown above are clones which were predicted to highly possibly belong to the category of glycoprotein-related protein based on the result of domain search by Pfam.
  • the 11 clones shown above are clones which were predicted to highly possibly belong to the category of signal transduction-related protein based on the result of domain search by Pfam.
  • the 18 clones shown above are clones which were predicted to highly possibly belong to the category of transcription-related protein based on the result of domain search by Pfam.
  • the 35 clones shown above are clones which were predicted to highly possibly belong to the category of enzyme and/or metabolism-related protein based on the result of domain search by Pfam.
  • the two clones shown above are clones which were predicted to highly possibly belong to the category of cell division and/or cell proliferation-related protein based on the result of domain search by Pfam.
  • the three clones shown above are clones which were predicted to highly possibly belong to the category of cytoskeleton-related protein based on the result of domain search by Pfam.
  • the two clones shown above are clones which were predicted to highly possibly belong to the category of nuclear protein and/or RNA synthesis-related protein based on the result of domain search by Pfam.
  • the 21 clones shown above are clones which were predicted to highly possibly belong to the category of DNA-binding and/or RNA-binding protein based on the result of domain search by Pfam.
  • the four clones shown above are clones which were predicted to highly possibly belong to the category of ATP-binding and/or GTP-binding protein based on the result of domain search by Pfam.
  • the 205 clones shown below are clones which were unassignable to any of the above-mentioned categories, but have been predicted to have some functions based on homology search for their full-length nucleotide sequences and motif search in their deduced ORFs.
  • the cDNA libraries derived from various tissues and cells as indicated in Example 1 were prepared, and cDNA clones were selected from each library at random.
  • the 5′-end sequences were determined and the database was constructed based on the data.
  • the database was constructed based on the nucleotide sequences of 770,546 clones, and thus the population of the database is large enough for the analysis.
  • clones having a homologous sequence are categorized into a single cluster (clustering) by searching the nucleotide sequences of respective clones in this database with the program of nucleotide sequence homology search; the number of clones belonging to each cluster was determined and normalized for every library; thus, the ratio of a certain gene in each cDNA library was determined.
  • This analysis gave the information of the expression frequency of genes in tissues and cells which were sources of the cDNA libraries.
  • the library derived from a tissue or a cell used in the large-scale cDNA analysis was subjected to the comparison of the expression levels between tissues or cells.
  • the expression frequency was analyzed by comparing the previously normalized values between tissues and/or cells for which the nucleotide sequences of 600 or more cDNA clones had been analyzed.
  • Tables 3 to 39 shown below represents a relative expression frequency; the higher the value, the higher the expression level.
  • Osteoporosis is a pathology in which bones are easily broken owing to overall decrease in components of bone. The onset involves the balance between the functions of osteoblast producing bone and osteoclast absorbing bone, namely bone metabolism. Thus, the genes involved in the increase of osteoclasts differentiating from precursor cells of monocyte/macrophage line (Molecular Medicine 38. 642-648. (2001)) are genes involved in osteoporosis relevant to bone metabolism.
  • Genes involved in neural cell differentiation are useful for treating neurological diseases. Genes with varying expression levels in response to induction of cellular differentiation in neural cells are thought to be involved in neurological diseases.
  • genes are neurological disease-related genes.
  • cancer tissues express a distinct set of genes, and thus the expression can contribute to the carcinogenesis in tissues and cells.
  • the genes whose expression patterns in cancer tissues are different from those in normal tissues are cancer-related genes. Search was carried out for the genes whose expression levels in cancer tissues were different from those in normal tissues.
  • genes involved in development and differentiation are genes participating in tissue construction and expression of function, and thus are useful genes, which are available for regenerative medicine aiming at convenient regeneration of injured tissues.
  • PCR primers were prepared based on the full-length nucleotide sequences, and the expression frequency was analyzed by the ATAC-PCR method (Adaptor-tagged competitive PCR method: Nucleic Acids Research 1997, 25 (22): 4694-4696; “DNA Micro-array and Advanced PCR Techniques”, Cell Technology, supplement, Eds., Muramatsu and Nawa (Shujunsha, 2000): 104-112). Inflammation-related genes can be identified by revealing the genes whose expression levels are altered depending on the presence of an inflammation-inducing factor.
  • THP-1 cell line which is a cell line of monocyte line
  • TNF- ⁇ which is an inflammation-inducing factor
  • THP-1 cell line (purchased from DAINIPPON PHARMACEUTICAL) was cultured to be confluent in RPMI1640 medium (sigma) containing 5% fetal calf serum (GIBCO BRL). Then, the medium was changed with the medium containing 10 ng/ml TNF- ⁇ (human recombinant TNF- ⁇ ; Pharmacia Biotech), and the culture was continued at 37° C. under 5% CO 2 . After three hours, the cells were harvested, and total RNA was extracted from them by using ISOGEN reagent (Nippon Gene). The extraction was carried out according to the method in the document attached to ISOGEN reagent. In addition, total RNA was also extracted from the cells cultured without stimulation of TNF- ⁇ .
  • the genes involved in the onset of gastritis and gastroduodenal ulcer induced by the infection of Helicobacter pylori to the epithelia of stomach can be identified by revealing the genes whose expression levels are altered depending on co-culturing the cells with Helicobacter pylori .
  • a recent study has suggested that various substances derived from Helicobacter pylori trigger the inflammation reaction.
  • the members belonging to the family of genes called “cag pathogenicity island (cag PAI)” contribute to the activation of the NF- ⁇ B pathway (Gastroenterology 2000, 119: 97-108).
  • cag PAI is involved in the onset of gastritis and the like by the study using an animal model (Journal of Experimental Medicine 2000, 192:1601-1610). Then, by using co-culture of a gastric cancer cell line with cag PAI-positive Helicobacter pylori (TN2), suitable for this system, the genes whose expression levels are altered depending on the presence of Helicobacter pylori were searched for by the system.
  • TN2 cag PAI-positive Helicobacter pylori
  • the altered expression levels were compared between the cells co-cultured with a strain of Helicobacter pylori (TN2 ⁇ cagE strain) having a mutation in cagE, which is one of the cag PAI genes, and the cag PAI-positive strain (TN2).
  • a gastric cancer cell line MKN45 (provided by the Cell Bank, RIKEN GENE BANK, The Institute of Physical and Chemical Research) was cultured to be confluent in RPMI1640 medium (sigma) containing 10% fetal calf serum (GIBCO BRL). Then, the medium was changed with the medium containing 100-fold excess (in terms of the number of cells or the number of colonies) of Helicobacter pylori (cag PAI positive strain (TN2) and cagE mutant (TN2 ⁇ cagE): both were provided by Prof. Omata, Faculty of Medicine, The University of Tokyo), as compared with the number of the cancer cells. The culture was continued at 37° C. under 5% CO 2 .
  • the analysis by the ATAC-PCR method was carried out basically according to “DNA Micro-array and Advanced PCR Techniques”, Cell Technology, supplement (Genome Science Series 1, Eds., Muramatsu and Nawa (Shujunsha, 2000): 104-112).
  • Adapter ligation to the internal standard sample (sample to make the calibration curve for the clone of interest) and test sample was carried out in the two separate reaction systems indicated below.
  • the combination of 6 types of adapters (AD-1, AD-2, AD-3, AD-4, AD-5 and AD-6: see the sequences indicated below) and the samples are as follows.
  • AD1 SEQ ID NO: 3941 5′-GTACATATTGTCGTTAGAACGCG-3′// SEQ ID NO: 3942 3′-CATGTATAACAGCAATCTTGCGCCTAG-5′// AD2; SEQ ID NO: 3943 5′-GTACATATTGTCGTTAGAACGCGACT-3′// SEQ ID NO: 3944 3′-CATGTATAACAGCAATCTTGCGCTGACTAG-5′// AD3; SEQ ID NO: 3945 5′-GTACATATTGTCGTTAGAACGCGCATACT-3′// SEQ ID NO: 3946 3′-CATGTATAACAGCAATCTTGCGCGTATGACTAG-5′// AD4; SEQ ID NO: 3947 5′-GTACATATTGTCGTTAGAACGCGATCCATACT-3′// SEQ ID NO: 3948 3′-CATGTATAACAGCAATCTTGCGCTAGGTATGACTAG-5′// AD5; SEQ ID NO: 3949 5′-GTACATATTGTCGTTAGAACGCG
  • the sequences of primers specific to the genes and the names of clones of interest in the analysis are as follows.
  • the gene specific primers were designed to produce the PCR products of 70 to 200 bp, which are derived from the adapter-containing cDNA.
  • the sequence of adapter-specific primer (labeled with fluorescence (FAM)) used in the competitive PCR was GTACATATTGTCGTTAGAACGC (22 nucleotides; SEQ ID NO: 3953).
  • PCR was basically carried out with a cycling profile of preheating at 94° C. for 3 minutes, and 35 or 40 cycles of denaturation at 94° C. for 30 seconds/annealing at 50° C. for 60 seconds/extension at 72° C. for 90 seconds.
  • the result of expression frequency analysis is shown in Table 40.
  • the clones not shown in the table contain clones whose expression levels could not be measured because the levels were too low or the sizes of the PCR products were different from the expected. It was confirmed that the expression levels of IL-8 gene used as a positive control gene were elevated.
  • the clones whose expression levels were decreased by twofold or more by the TNF- ⁇ stimulation were BNGH420052350, BRACE20052530, BRAMY20003880, CTONG20170940, FCBBF30022680, FCBBF30225930, FCBBF30257370, FEBRA20046280, KIDNE20084030, KIDNE20188630, NT2NE20082130, OCBBF20110210, PLACE60061370, PROST20041460, PROST20075280, PROST20110120, SMINT20006020, TESTI20046540, TESTI20057200, TESTI20113940, TESTI20257910, TESTI20262940, TRACH20149740.
  • the expression levels of BRAMY20035380, SKMUS20091900, SPLEN20040780, UTERU20064120, CTONG20170940, OCBBF20142290, TESTI20030610 were not increased by the co-culture with the cagE mutant (TN2 ⁇ cagE). There may be the possibility that the expression levels of the 7 clones are altered via the NF- ⁇ B pathway. Among them, the expression levels of OCBBF20142290, SPLEN20040780, TESTI20030610, UTERU20064120 were also increased when human monocyte cell line THP-1 was stimulated with TNF- ⁇ .
  • the clones whose expression levels were decreased by twofold or more in the presence of Helicobacter pylori were ASTRO20088950, BRACE20052530, BRAMY20003880, BRAMY20027390, BRAMY20036530, BRAMY20118410, BRHIP20000210, FCBBF20032930, FCBBF30022680, FCBBF30169870, FEBRA20182030, KIDNE20182540, LIVER20007750, MESAN20021220, NT2NE20059210, NT2NE20082130, OCBBF20155030, PROST20065100, PROST20075280, SPLEN20110860, TESTI20057200, TESTI20113940, TESTI20149880, TESTI20151800, TESTI20198600, TESTI20257910, THYMU20046770, THYMU200585
  • BRAMY20072870 0 0 0 0 0 23.589 0 0 0 0 0 0 0 0 BRAMY20073080 0 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20074110 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20074860 0 0 0 0 0 0 0 100 0 0 0 0 0 0 BRAMY20076100 0 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20076130 10.199 6.928 0 6.552 9.974 18.955 0 0 0 0 19.628 0 9.927 0 BRAMY20076530 0 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20083330 0 0 0 0 0
  • CTONG20080140 0 0 0 0 0 0 0 0 0 28.14 44.187 0 0 CTONG20085210 44.007 0 0 0 0 0 0 0 0 28.231 0 0 0 CTONG20133720 0 0 0 0 0 0 5.755 0 0 0 5.959 0 0 0 CTONG20165750 23.734 0 18.524 0 0 0 0 0 0 0 0 0 CTONG20168240 18.734 0 0 0 0 0 0 0 0 0 0 0 0 CTONG20170940 0 0 0 0 0 0 0 10.747 0 0 0 0 0 0 0 CTONG20183430 44.214 0 0 0 0 0 0 0 0 0 0 0 CTONG20186370 31.217 0 0 0 0 0 0 0
  • FCBBF30001150 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30002270 20.773 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30002280 100 0 0 0 0 0 0 0 0 0 0 FCBBF30002330 100 0 0 0 0 0 0 0 0 0 0 0 FCBBF30003610 100 0 0 0 0 0 0 0 0 0 0 0 FCBBF30004340 8.95 0 8.731 17.248 8.752 5.544 0 11.114 0 11.482 9.015 0 0 FCBBF30004730 100 0 0 0 0 0 0 0 0 0 0 FCBBF30005180 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
  • FCBBF30088700 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30089380 51.503 0 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30091010 100 0 0 0 0 0 0 0 0 0 0 0 FCBBF30091520 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30093170 72.234 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30095410 20.765 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30099490 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30100080 100 0 0 0 0 0 0 0 0 0 0
  • FCBBF30145670 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30151190 100 0 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30153170 100 0 0 0 0 0 0 0 0 0 0 0 FCBBF30157270 56.537 0 0 0 0 0 0 0 0 0 0 0 FCBBF30161780 100 0 0 0 0 0 0 0 0 0 0 0 FCBBF30164510 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30166220 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30169280 16.742 0 0 0 0 0 0 0 0 0 0
  • FCBBF30257370 15.348 13.901 0 0 0 0 0 0 0 0 0 0 9.959 0 FCBBF30259050 43.768 0 0 56.232 0 0 0 0 0 0 0 0 0 0 FCBBF30260210 100 0 0 0 0 0 0 0 0 0 0 FCBBF30260480 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30263080 23.584 0 0 0 0 0 0 29.288 0 0 0 0 0 FCBBF30266510 56.537 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30271990 100 0 0 0 0 0 0 0 0 0 0 0 FCBBF30275590 100 0 0 0 0 0 0
  • NT2RP70035110 12.287 0 0 0 0 0 0 0 0 0 0 0 0 0 NT2RP70057500 7.128 0 13.909 0 0 0 0 0 0 0 0 0 0 NT2RP70075300 3.525 0 3.439 2.264 0 2.184 0 0 0 0 0 0 0 NT2RP70087140 3.902 10.602 0 10.026 0 24.172 0 0 0 0 0 0 21.047 NT2RP70090870 17.949 0 17.511 0 0 0 0 0 0 0 0 0 0 0 0 NTONG20002230 0 0 24.855 0 0 0 0 0 0 0 0 0 0 0 0 NTONG20017620 22.333 0 14.526 0 0 0 18.447 0 0 0 0 0
  • PROST20035830 34.251 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PROST20042700 13.112 0 0 0 0 0 0 16.283 0 0 0 0 0 0 0 PROST20045700 11.365 0 0 0 22.229 0 0 0 0 0 0 0 0 PROST20050390 23.916 0 0 0 0 0 0 0 0 0 0 0 0 PROST20054660 0 0 0 0 40.095 0 0 0 0 0 0 0 0 0 0 PROST20078710 0 0 33.455 0 0 0 0 0 0 0 0 0 0 0 PROST20094000 0 0 0 27.644 0 0 0 0 0 0 0 0 0 0 PROST20097310 0 0
  • THYMU20055460 5.716 0 5.577 0 0 0 0 0 0 3.667 0 11.127 0 THYMU20055740 0 0 0 54.873 0 0 0 0 0 0 0 0 0 0 THYMU20071120 3.627 0 3.539 0 0 0 0 0 0 0 0 0 0 THYMU20078020 0 56.251 0 0 0 0 0 0 0 0 0 0 0 THYMU20089900 0 0 0 0 0 0 0 0 0 30.29 0 0 THYMU20091040 0 0 0 0 0 25.102 0 0 19.425 0 20.408 0 0 THYMU20104480 0 0 0 22.379 0 0 14.21 0 0 0 0 0 0 0 0 THYMU20120240 7.548 0 0
  • ctl, TNF_1h, and TNF_3h in the column of THP-1 indicate the relative mRNA expression levels in unstimulated THP-1, in the cell stimulated with 10 ng/mL TNF- ⁇ for 1 hour, and in the cell stimulated with 10 ng/mL TNF- ⁇ for 3 hours;
  • TN2 PAI- positive Helicobacter pylori
  • both units, aa and bp, are used as length units for the sequences to be compared.
  • Each data includes Clone name, Definition in hit data, P value, Length of sequence to be compared, Homology, and Accession number (No.) of hit data. These items are shown in this order and separated by a double-slash mark, //.

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Abstract

Novel full-length cDNAs are provided. 1970 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.

Description

    FIELD OF THE INVENTION
  • The present invention relates to polynucleotides encoding novel polypeptides, polypeptides encoded by the polynucleotides, and new uses of these.
    • BACKGROUND OF THE INVENTION
  • Currently, the sequencing projects, the determination and analysis of the genomic DNA of various living organisms have been in progress all over the world. The whole genomic sequences of more than 40 species of prokaryotes, a lower eukaryote, yeast, a multicellular eukaryote, C. elegans, and a higher plants, arabidopsis, etc. are already determined. For human genome, presumably having 3 billion base pairs, the analysis was advanced under global cooperative organization, and a draft sequence was disclosed in 2001. Moreover, all the structures are to be clear and to be disclosed in 2002-2003. The aim of the determination of genomic sequence is to reveal the functions of all genes and their regulation and to understand living organisms as a network of interactions between genes, proteins, cells or individuals through deducing the information in a genome, which is a blueprint of the highly complicated living organisms. To understand living organisms by utilizing the genomic information from various species is not only important as an academic subject, but also socially significant from the viewpoint of industrial application.
  • However, determination of genomic sequences itself cannot identify the functions of all genes. For example, as for yeast, only the function of approximately half of the 6000 genes, which is predicted based on the genomic sequence, was able to be deduced. On the other hand, the human genome has been estimated to contain about 30,000-40,000 genes. Further, 100,000 or more types of mRNAs are said to exist when variants produced by alternative splicing are taken into consideration. Therefore, it is desirable to establish “a high throughput analysis system of the gene functions” which allows us to identify rapidly and efficiently the functions of vast amounts of the genes obtained by the genomic sequencing.
  • Many genes in the eukaryotic genome are split by introns into multiple exons. Thus, it is difficult to predict correctly the structure of encoded protein solely based on genomic information. In contrast, cDNA, which is produced from mRNA that lacks introns, encodes a protein as a single continuous amino acid sequence and allows us to identify the primary structure of the protein easily. In human cDNA research, to date, more than three million ESTs (Expression Sequence Tags) are publicly available, and the ESTs presumably cover not less than 80% of all human genes.
  • The information of ESTs is utilized for analyzing the structure of human genome, or for predicting the exon-regions of genomic sequences or their expression profile. However, many human ESTs have been derived from proximal regions to the 3′-end of cDNA, and information around the 5′-end of mRNA is extremely little. Among human cDNAs, the number of the corresponding mRNAs whose encoding full-length protein sequences are deduced is approximately 13,000.
  • It is possible to identify the transcription start site of mRNA on the genomic sequence based on the 5′-end sequence of a full-length cDNA, and to analyze factors involved in the stability of mRNA that is contained in the cDNA, or in its regulation of expression at the translation stage. Also, since a full-length cDNA contains atg codon, the translation start site, in the 5′-region, it can be translated into a protein in a correct frame. Therefore, it is possible to produce a large amount of the protein encoded by the cDNA or to analyze biological activity of the expressed protein by utilizing an appropriate expression system. Thus, analysis of a full-length cDNA provides valuable information which complements the information from genome sequencing. Also, full-length cDNA clones that can be expressed are extremely valuable in empirical analysis of gene function and in industrial application.
  • Therefore, if a novel human full-length cDNA is isolated, it can be used for developing medicines for diseases in which the gene is involved. The protein encoded by the gene can be used as a drug by itself. Thus, it has great significance to obtain a full-length cDNA encoding a novel human protein.
  • In particular, human secretory proteins or membrane proteins would be useful by itself as a medicine like tissue plasminogen activator (TPA), or as a target of medicines like membrane receptors. In addition, genes for signal transduction-related proteins (protein kinases, etc.), glycoprotein-related proteins, transcription-related proteins, etc. are genes whose relationships to human diseases have been elucidated. Moreover, genes for disease-related proteins form a gene group rich in genes whose relationships to human diseases have been elucidated.
  • Therefore, it has great significance to isolate novel full-length cDNA clones of human, only few of which has been isolated. Especially, isolation of a novel cDNA clone encoding a secretory protein or membrane protein is desired since the protein itself would be useful as a medicine, and also the clones potentially include a gene involved in diseases. In addition, genes encoding proteins that are involved in signal transduction, glycoprotein, transcription, or diseases are expected to be useful as target molecules for therapy, or as medicines themselves. These genes form a gene group predicted to be strongly involved in diseases. Thus, identification of the full-length cDNA clones encoding those proteins has great significance.
    • SUMMARY OF THE INVENTION
  • An objective of the present invention is to provide polynucleotides encoding novel polypeptides, polypeptides encoded by the polynucleotides, and novel usages of these.
  • The inventors have developed a method for efficiently cloning, from a cDNA library having very high fullness-ratio, a human full-length cDNA that is predicted to be a full-length cDNA clone, where the cDNA library is synthesized by an improved method (WO 01/04286) of the oligo-capping method (K. Maruyama and S. Sugano, Gene, 138: 171-174 (1994); Y. Suzuki et al., Gene, 200: 149-156 (1997)). Then, the nucleotide sequences of cDNA clones whose fullness ratio is high, obtained by this method, were determined mainly from their 5′-ends, and, if required, from 3′-ends.
  • Further, representative clones, which were estimated to be novel and full-length, among the clones obtained, were analyzed for their full-length nucleotide sequences. The determined full-length nucleotide sequences were analyzed by BLAST homology search of the databases shown below. Because the homology search of the present invention is carried out based on the information of full-length cDNAs including the entire coding regions, homology to every part of a polypeptide can be analyzed. Thus, in the present invention, the reliability of homology search has been greatly improved.
    • [1] Swissprot (http://www.ebi.ac.uk/ebi_docsSwissProt_db/swisshome.html),
    • [2] GenBank (http://www.ncbi.nlm.nih.gov/web/GenBank),
    • [3] UniGene (Human) (http://www.ncbi.nlm.nih.gov/UniGene), and
    • [4] nr (a protein database, which has been constructed by combining data of coding sequences (CDS) in nucleotide sequences deposited in GenBank, and data of SwissProt, PDB (http://www.rcsb.org/pdb/index.html), PIR (http://pir.georgetown.edu/pirwww/pirhome.shtml), and PRF (http://www.prf.or.jp/en/); overlapping sequences have been removed.)
  • Further, the gene expression profiles of cDNA clones whose full-length nucleotide sequence had been determined were studied by analyzing the large-scale cDNA database constructed based on the 5′-end nucleotide sequences of cDNAs obtained. In addition to the analysis for the expression profile by computer, the profiles of gene expression in living cells were also determined by PCR. The present inventors revealed the usefulness of the genes of the present invention based on these analysis results.
  • In the present invention, gene functions were revealed by the analysis of expression profiles in silico based on the information of full-length nucleotide sequences. The expression profiles used in the expression frequency analysis were studied based on the database containing sufficient amount of fragment sequence data. The expression frequency analysis was carried out by referring, for these expression profiles, to the full-length nucleotide sequences of many cDNA clones obtained in the present invention. Thus, a highly reliable analysis can be achieved by referring to the full-length nucleotide sequences of a wide variety of genes for the sufficiently large population for analysis (expression profiles). Namely, the results of expression frequency analysis using the full-length sequences of the present invention more precisely reflect the gene expression frequency in tissues and cells from which a certain cDNA library was derived. In other words, the information of full-length cDNA nucleotide sequence of the present invention made it possible to achieve the highly reliable expression frequency analysis.
  • The full-length cDNA clones of this invention were obtained by the method comprising the steps of [1] preparing libraries containing cDNAs with the high fullness ratio by oligo-capping, and [2] assembling 5′-end sequences and selecting one with the highest probability of completeness in length in the cluster formed (there are many clones longer in the 5′-end direction). However, the uses of primers designed based on the 5′- and 3′-end sequences of polynucleotides provided by the present invention enable readily obtaining full-length cDNAs without such a special technique. The primer, which is designed to be used for obtaining cDNAs capable of being expressed, is not limited to the 5′- and 3′-end sequences of polynucleotide.
  • Specifically, the present invention relates to a polynucleotide selected from the group consisting of the following (a) to (g):
      • (a) a polynucleotide comprising a protein-coding region of the nucleotide sequence of any one of SEQ ID NOs shown in Table 1;
      • (b) a polynucleotide encoding a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs shown in Table 1;
      • (c) a polynucleotide comprising a nucleotide sequence encoding a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs shown in Table 1, wherein, in said amino acid sequence, one or more amino acids have been substituted, deleted, inserted, and/or added, and wherein said nucleotide sequence encodes a polypeptide functionally equivalent to a polypeptide comprising the selected amino acid sequence;
      • (d) a polynucleotide hybridizing under stringent conditions to a polynucleotide comprising the nucleotide sequence of any one of SEQ ID NOs shown in Table 1, wherein said nucleotide sequence encodes a polypeptide functionally equivalent to a polypeptide encoded by the selected nucleotide sequence;
      • (e) a polynucleotide comprising a nucleotide sequence encoding a partial amino acid sequence of a polypeptide encoded by the polynucleotide according to any one of (a) to (d);
      • (f) a polynucleotide comprising a nucleotide sequence having at least 70% identity to the nucleotide sequence of (a); and
      • (g) a polynucleotide comprising a nucleotide sequence having at least 90% identity to the nucleotide sequence of (a).
  • The present invention also relates to a polypeptide encoded by the above-mentioned polynucleotide or a partial peptide thereof, an antibody binding to the polypeptide or the peptide, and a method for immunologically assaying the polypeptide or the peptide, which comprises the steps of contacting the polypeptide or the peptide with the antibody, and observing the binding between the two.
  • Furthermore, the present invention features a vector comprising the above-mentioned polynucleotide, a transformant carrying the polynucleotide or the vector, a transformant carrying the polynucleotide or the vector in an expressible manner, and a method for producing the polypeptide or the peptide, which comprises the steps of culturing the transformant and recovering an expression product.
  • Another feature of the present invention is an oligonucleotide comprising at least 15 nucleotides, said oligonucleotide comprising a nucleotide sequence complementary to the nucleotide sequence of any one of SEQ ID NOs: 1 to 1970 or to a complementary strand thereof. This oligonucleotide can be used as a primer for synthesizing the above-mentioned polynucleotide or used as a probe for detecting the polynucleotide. The present invention includes an antisense polynucleotide against the polynucleotide or a part thereof, and a method for detecting the polynucleotide, which comprises the following steps of:
    • a) incubating a target polynucleotide with the oligonucleotide under hybridizable conditions, and
    • b) detecting hybridization of the target polynucleotide with the oligonucleotide.
  • Still another feature of the present invention is a database of polynucleotides and/or polypeptides, said database comprising information on at least one of the nucleotide sequences of SEQ ID NOs: 1 to 1970 and/or on at least one of the amino acid sequences of SEQ ID NOs: 1971 to 3940.
  • Herein, “polynucleotide” is defined as a molecule, such as DNA and RNA, in which multiple nucleotides are polymerized. There are no limitations on the number of the polymerized nucleotides. In case that the polymer contains relatively low number of nucleotides, it is also described as an “oligonucleotide”, which is included in the “polynucleotide” of the present invention. The polynucleotide or the oligonucleotide of the present invention can be a natural or chemically synthesized product. Alternatively, it can be synthesized using a template polynucleotide by an enzymatic reaction such as PCR. Furthermore, the polynucleotide of the present invention may be modified chemically. Moreover, not only a single-strand polynucleotide but also a double-strand polynucleotide is included in the present invention. In this specification, especially in claims, when the polynucleotide is described merely as “polynucleotide”, it means not only a single-strand polynucleotide but also a double-strand polynucleotide. When it means double-strand polynucleotide, the nucleotide sequence of only one chain is indicated. However, based on the nucleotide sequence of a sense chain, the nucleotide sequence of the complementary strand thereof is essentially determined.
  • As used herein, an “isolated polynucleotide” is a polynucleotide the structure of which is not identical to that of any naturally occurring polynucleotide or to that of any fragment of a naturally occurring genomic polynucleotide spanning more than three separate genes. The term therefore includes, for example, (a) a DNA which has the sequence of part of a naturally occurring genomic DNA molecule in the genome of the organism in which it naturally occurs; (b) a polynucleotide incorporated into a vector or into the genomic DNA of a prokaryote or eukaryote in a manner such that the resulting molecule is not identical to any naturally occurring vector or genomic DNA; (c) a separate molecule such as a cDNA, a genomic fragment, a fragment produced by polymerase chain reaction (PCR) or a restriction fragment; and (d) a recombinant nucleotide sequence that is part of a hybrid gene, i.e., a gene encoding a fusion polypeptide. Specifically excluded from this definition are polynucleotides of DNA molecules present in mixtures of different (i) DNA molecules, (ii) transfected cells, or (iii) cell clones; e.g., as these occur in a DNA library such as a cDNA or genomic DNA library.
  • The term “substantially pure” as used herein in reference to a given protein or polypeptide means that the protein or polypeptide is substantially free from other biological macromolecules. For example, the substantially pure protein or polypeptide is at least 75%, 80%, 85%, 95%, or 99% pure by dry weight. Purity can be measured by any appropriate standard method known in the art, for example, by column chromatography, polyacrylamide gel electrophoresis, or HPLC analysis.
  • All the cDNAs provided by the present invention are full-length cDNAs. The “full-length cDNA” herein means that the cDNA contains the ATG codon, which is the start point of translation therein. The untranslated regions upstream and downstream of the protein-coding region, both of which are naturally contained in natural mRNAs, are not indispensable. It is preferable that the full-length cDNAs of the present invention contain the stop codon.
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 shows the restriction map of the vector pME18SFL3.
    • DETAILED DESCRIPTION OF THE INVENTION
  • All the clones (1970 clones) of the present invention are novel and encode the full-length polypeptides. Further, all the clones are cDNAs with the high fullness ratio, which were obtained by oligo-capping method, and also clones which are not identical to any of known human mRNAs (namely, novel clones) selected by searching, for the 5′-end sequences, mRNA sequences with the annotation of “complete cds” in the GenBank and UniGene databases by using the BLAST homology search [S. F. Altschul, W. Gish, W. Miller, E. W. Myers & D. J. Lipman, J. Mol. Biol., 215: 403-410 (1990); W. Gish & D. J. States, Nature Genet., 3: 266-272 (1993)]; they are also clones that were assumed to have higher fullness ratio among the members in the cluster formed by assembling. Most of the clones assessed to have high fullness ratio in the cluster had the nucleotide sequences longer in the 5′-end direction.
  • All the full-length cDNAs of the present invention can be synthesized by a method such as PCR (Current protocols in Molecular Biology edit. Ausubel et al. (1987) Publish. John Wiley & Sons Section 6.1-6.4) using primer sets designed based on the 5′-end and 3′-end sequences or using primer sets of primers designed based on the 5′-end sequences and a primer of oligo dT sequence corresponding to poly A sequence. Table 1 contains the clone names of full-length cDNA of 1970 clones of the present invention, SEQ ID NOs of the full-length nucleotide sequences, CDS portions deduced from the full-length nucleotide sequences, and SEQ ID NOs of the translated amino acids. The positions of CDS are shown according to the rule of “DDBJ/EMBL/GenBank Feature Table Definition” (http://www.ncbi.nlm.nih.gov/collab/FT/index.html). The start position number corresponds to the first letter of “ATG” that is the nucleotide triplet encoding methionine; the termination position number corresponds to the third letter of the stop codon. These are indicated being flanked with the mark “ . . . ”. However, with respect to the clones having no stop codon, the termination position is indicated by the mark “>” according to the above rule.
    TABLE 1
    SEQ ID NO. SEQ ID NO.
    Clone of nucleotide Position of amino acid
    name sequence of CDS sequence
    ADRGL20020290 1  62 . . . 1669 1971
    ADRGL20021910 2 150 . . . 707 1972
    ADRGL20022600 3 464 . . . 814 1973
    ADRGL20023920 4  375 . . . 1853 1974
    ADRGL20026790 5  113 . . . 2371 1975
    ADRGL20027530 6 2013 . . . 2372 1976
    ADRGL20036380 7 1129 . . . 1557 1977
    ADRGL20036840 8 260 . . . 889 1978
    ADRGL20040310 9 539 . . . 844 1979
    ADRGL20040770 10  817 . . . 1227 1980
    ADRGL20046760 11 1108 . . . 1467 1981
    ADRGL20047080 12  823 . . . 1134 1982
    ADRGL20047770 13 1532 . . . 1897 1983
    ADRGL20057560 14 376 . . . 846 1984
    ADRGL20059610 15  969 . . . 1961 1985
    ADRGL20062330 16    799 . . . >2117 1986
    ADRGL20063770 17 344 . . . 664 1987
    ADRGL20066770 18  22 . . . 1416 1988
    ADRGL20067320 19  276 . . . 1016 1989
    ADRGL20079060 20  63 . . . 1748 1990
    ADRGL20095330 21  929 . . . 1516 1991
    ASTRO20001910 22   1753 . . . >2216 1992
    ASTRO20003720 23 2089 . . . 2586 1993
    ASTRO20004820 24  444 . . . 1040 1994
    ASTRO20006530 25   2 . . . 1123 1995
    ASTRO20009140 26  344 . . . 1714 1996
    ASTRO20010010 27 1236 . . . 1727 1997
    ASTRO20010290 28  2 . . . 745 1998
    ASTRO20012270 29 286 . . . 627 1999
    ASTRO20020240 30  12 . . . 335 2000
    ASTRO20020350 31 1384 . . . 1854 2001
    ASTRO20022020 32  467 . . . 1093 2002
    ASTRO20026320 33  473 . . . 2161 2003
    ASTRO20027330 34  481 . . . 1101 2004
    ASTRO20038400 35  52 . . . 2025 2005
    ASTRO20045840 36  263 . . . 1051 2006
    ASTRO20046280 37  140 . . . 1402 2007
    ASTRO20047510 38 1240 . . . 1611 2008
    ASTRO20050810 39  171 . . . 1694 2009
    ASTRO20052420 40 1166 . . . 2362 2010
    ASTRO20053430 41  218 . . . 1885 2011
    ASTRO20055530 42 209 . . . 559 2012
    ASTRO20055570 43 242 . . . 733 2013
    ASTRO20055930 44  343 . . . 1086 2014
    ASTRO20058960 45  55 . . . 1215 2015
    ASTRO20069200 46  71 . . . 1237 2016
    ASTRO20075150 47 1004 . . . 1795 2017
    ASTRO20076660 48 1594 . . . 1968 2018
    ASTRO20085080 49  470 . . . 2011 2019
    ASTRO20088950 50  346 . . . 1530 2020
    ASTRO20089600 51  142 . . . 1125 2021
    ASTRO20090680 52   1221 . . . >2631 2022
    ASTRO20091180 53  12 . . . 1214 2023
    ASTRO20091770 54  10 . . . 318 2024
    ASTRO20141740 55  30 . . . 347 2025
    BGGI120000670 56 240 . . . 614 2026
    BGGI120010750 57    72 . . . >2507 2027
    BNGH410000570 58  957 . . . 2027 2028
    BNGH420008150 59  596 . . . 1606 2029
    BNGH420014060 60 1072 . . . 1413 2030
    BNGH420015760 61  92 . . . 1336 2031
    BNGH420021680 62  147 . . . 2093 2032
    BNGH420023870 63  301 . . . 1851 2033
    BNGH420024870 64  155 . . . 1960 2034
    BNGH420035290 65  114 . . . 2126 2035
    BNGH420036410 66 1778 . . . 2143 2036
    BNGH420040760 67  698 . . . 1162 2037
    BNGH420042910 68 191 . . . 721 2038
    BNGH420045380 69  721 . . . 1254 2039
    BNGH420046790 70 1079 . . . 1429 2040
    BNGH420052350 71  787 . . . 1146 2041
    BNGH420059680 72  213 . . . 2393 2042
    BNGH420061350 73  600 . . . 3131 2043
    BNGH420062340 74 294 . . . 641 2044
    BNGH420070370 75  567 . . . 2429 2045
    BNGH420074600 76  125 . . . 1696 2046
    BNGH420075940 77  31 . . . 510 2047
    BNGH420077980 78  288 . . . 2147 2048
    BNGH420085100 79 243 . . . 569 2049
    BNGH420086030 80    107 . . . >2556 2050
    BNGH420087430 81  195 . . . 1835 2051
    BRACE10000510 82  642 . . . 1703 2052
    BRACE20003310 83 1379 . . . 2893 2053
    BRACE20007330 84  339 . . . 2015 2054
    BRACE20009050 85 1023 . . . 1493 2055
    BRACE20014450 86  161 . . . 1096 2056
    BRACE20017790 87 304 . . . 639 2057
    BRACE20018810 88  397 . . . 1146 2058
    BRACE20025820 89 453 . . . 767 2059
    BRACE20038920 90 1122 . . . 1463 2060
    BRACE20050870 91  110 . . . 1987 2061
    BRACE20051600 92 443 . . . 895 2062
    BRACE20051930 93 173 . . . 901 2063
    BRACE20052430 94  825 . . . 1637 2064
    BRACE20052530 95  98 . . . 490 2065
    BRACE20054080 96  762 . . . 1382 2066
    BRACE20054480 97 111 . . . 902 2067
    BRACE20054600 98  392 . . . 1276 2068
    BRACE20055560 99 136 . . . 735 2069
    BRACE20057870 100 1169 . . . 1825 2070
    BRACE20059110 101 1452 . . . 1910 2071
    BRACE20059810 102  689 . . . 2218 2072
    BRACE20061620 103  162 . . . 1163 2073
    BRACE20062580 104 1164 . . . 1859 2074
    BRACE20063540 105  378 . . . 1670 2075
    BRACE20065470 106  427 . . . 1101 2076
    BRACE20066360 107 233 . . . 736 2077
    BRACE20068710 108 1099 . . . 1440 2078
    BRACE20069000 109 1355 . . . 2305 2079
    BRACE20069110 110 576 . . . 917 2080
    BRACE20069440 111  278 . . . 1504 2081
    BRACE20079200 112  928 . . . 1413 2082
    BRACE20079370 113  158 . . . 1522 2083
    BRACE20097540 114 1474 . . . 2103 2084
    BRACE20098860 115  693 . . . 1193 2085
    BRACE20099070 116  53 . . . 1441 2086
    BRACE20194670 117  11 . . . 616 2087
    BRACE20196180 118  35 . . . 916 2088
    BRACE20196960 119 1454 . . . 1912 2089
    BRACE20200770 120 306 . . . 683 2090
    BRACE20200970 121 426 . . . 764 2091
    BRACE20204670 122  760 . . . 2124 2092
    BRACE20205840 123  40 . . . 387 2093
    BRACE20207420 124 119 . . . 469 2094
    BRACE20212450 125 168 . . . 590 2095
    BRACE20215410 126  111 . . . 1361 2096
    BRACE20216700 127 1403 . . . 1738 2097
    BRACE20216950 128  911 . . . 1315 2098
    BRACE20219360 129 198 . . . 596 2099
    BRAMY10000980 130 254 . . . 616 2100
    BRAMY10001730 131  796 . . . 1158 2101
    BRAMY20000210 132 134 . . . 445 2102
    BRAMY20000250 133  190 . . . 1932 2103
    BRAMY20001510 134 129 . . . 917 2104
    BRAMY20003540 135  144 . . . 2477 2105
    BRAMY20003880 136 191 . . . 808 2106
    BRAMY20005080 137 1638 . . . 1958 2107
    BRAMY20013670 138  551 . . . 2881 2108
    BRAMY20016780 139  273 . . . 1985 2109
    BRAMY20020440 140 359 . . . 685 2110
    BRAMY20021580 141  67 . . . 555 2111
    BRAMY20023390 142 1568 . . . 1939 2112
    BRAMY20023640 143 1684 . . . 2280 2113
    BRAMY20024790 144 276 . . . 626 2114
    BRAMY20027390 145 420 . . . 782 2115
    BRAMY20027990 146  529 . . . 1572 2116
    BRAMY20028530 147  973 . . . 1278 2117
    BRAMY20028620 148 1048 . . . 1434 2118
    BRAMY20035380 149  925 . . . 1707 2119
    BRAMY20035830 150 219 . . . 977 2120
    BRAMY20036530 151 1411 . . . 1761 2121
    BRAMY20036810 152 321 . . . 644 2122
    BRAMY20038980 153    715 . . . >2057 2123
    BRAMY20039290 154  81 . . . 1043 2124
    BRAMY20040580 155 374 . . . 769 2125
    BRAMY20043520 156  942 . . . 1778 2126
    BRAMY20043630 157  25 . . . 1119 2127
    BRAMY20044920 158  40 . . . 1947 2128
    BRAMY20045210 159 367 . . . 750 2129
    BRAMY20045420 160  4 . . . 888 2130
    BRAMY20047560 161 220 . . . 726 2131
    BRAMY20050640 162 1802 . . . 2635 2132
    BRAMY20050940 163  23 . . . 385 2133
    BRAMY20051820 164 1411 . . . 2157 2134
    BRAMY20052440 165  29 . . . 448 2135
    BRAMY20053910 166  11 . . . 358 2136
    BRAMY20055760 167  664 . . . 2253 2137
    BRAMY20056620 168  46 . . . 726 2138
    BRAMY20056840 169  40 . . . 1392 2139
    BRAMY20063750 170  535 . . . 2166 2140
    BRAMY20072440 171  823 . . . 1620 2141
    BRAMY20072870 172 437 . . . 910 2142
    BRAMY20073080 173  3 . . . 353 2143
    BRAMY20074110 174 314 . . . 838 2144
    BRAMY20074860 175 1135 . . . 1524 2145
    BRAMY20076100 176  459 . . . 1019 2146
    BRAMY20076130 177  59 . . . 376 2147
    BRAMY20076530 178 1010 . . . 1465 2148
    BRAMY20083330 179  10 . . . 492 2149
    BRAMY20083820 180  625 . . . 1113 2150
    BRAMY20089770 181 173 . . . 955 2151
    BRAMY20091230 182  818 . . . 1579 2152
    BRAMY20093490 183  637 . . . 1080 2153
    BRAMY20094890 184  30 . . . 2138 2154
    BRAMY20095080 185 239 . . . 613 2155
    BRAMY20095570 186 109 . . . 807 2156
    BRAMY20096930 187 1381 . . . 1800 2157
    BRAMY20100680 188 268 . . . 870 2158
    BRAMY20102900 189 200 . . . 760 2159
    BRAMY20107980 190 343 . . . 669 2160
    BRAMY20111780 191  584 . . . 2209 2161
    BRAMY20117670 192  63 . . . 782 2162
    BRAMY20118410 193  24 . . . 782 2163
    BRAMY20118490 194  39 . . . 791 2164
    BRAMY20120170 195 1130 . . . 1459 2165
    BRAMY20123400 196 1420 . . . 1755 2166
    BRAMY20124970 197  825 . . . 1226 2167
    BRAMY20125170 198 157 . . . 579 2168
    BRAMY20125360 199  134 . . . 1060 2169
    BRAMY20125550 200  29 . . . 1747 2170
    BRAMY20126910 201 114 . . . 518 2171
    BRAMY20127310 202 1986 . . . 2336 2172
    BRAMY20127760 203 317 . . . 691 2173
    BRAMY20134050 204 199 . . . 522 2174
    BRAMY20135720 205  57 . . . 401 2175
    BRAMY20137360 206  976 . . . 2193 2176
    BRAMY20139440 207   2 . . . 1597 2177
    BRAMY20139750 208  88 . . . 435 2178
    BRAMY20143870 209 1419 . . . 2102 2179
    BRAMY20152510 210  296 . . . 1993 2180
    BRAMY20155500 211  722 . . . 1069 2181
    BRAMY20158550 212 142 . . . 951 2182
    BRAMY20159250 213 286 . . . 810 2183
    BRAMY20160020 214 143 . . . 919 2184
    BRAMY20173480 215 1544 . . . 1906 2185
    BRAMY20190550 216  114 . . . 1640 2186
    BRAMY20194680 217 1179 . . . 1517 2187
    BRAMY20204270 218 218 . . . 844 2188
    BRAMY20206340 219  237 . . . 1805 2189
    BRAMY20219620 220 1014 . . . 1670 2190
    BRAMY20221600 221 168 . . . 992 2191
    BRAMY20223010 222  466 . . . 1257 2192
    BRAMY20225250 223 368 . . . 673 2193
    BRAMY20225320 224 241 . . . 840 2194
    BRAMY20227230 225 1327 . . . 2067 2195
    BRAMY20227860 226  10 . . . 657 2196
    BRAMY20227960 227 1148 . . . 1558 2197
    BRAMY20231150 228  199 . . . 1146 2198
    BRAMY20234820 229  199 . . . 2079 2199
    BRAMY20237190 230 397 . . . 870 2200
    BRAMY20238630 231  303 . . . 1331 2201
    BRAMY20243120 232 1756 . . . 2451 2202
    BRAMY20244490 233 257 . . . 982 2203
    BRAMY20245140 234   3 . . . 1295 2204
    BRAMY20245350 235  94 . . . 750 2205
    BRAMY20245760 236  35 . . . 1375 2206
    BRAMY20251210 237  68 . . . 955 2207
    BRAMY20251750 238  97 . . . 846 2208
    BRAMY20263000 239  216 . . . 1553 2209
    BRAMY20267780 240 1194 . . . 1706 2210
    BRAMY20269040 241  989 . . . 2071 2211
    BRAMY20271140 242 1582 . . . 2238 2212
    BRAMY20274510 243 1785 . . . 2138 2213
    BRAMY20285650 244  23 . . . 382 2214
    BRAMY20287400 245  1 . . . 456 2215
    BRAWH20014590 246 125 . . . 856 2216
    BRAWH20020470 247    131 . . . >2130 2217
    BRAWH20020600 248 402 . . . 722 2218
    BRAWH20021910 249  394 . . . 1803 2219
    BRAWH20025490 250 1699 . . . 2106 2220
    BRAWH20026010 251  307 . . . 2034 2221
    BRAWH20027250 252  942 . . . 1499 2222
    BRAWH20030000 253  381 . . . 1286 2223
    BRAWH20039640 254    109 . . . >2281 2224
    BRAWH20040680 255  201 . . . 2291 2225
    BRAWH20047790 256 290 . . . 631 2226
    BRAWH20050740 257    512 . . . >1907 2227
    BRAWH20055240 258 1339 . . . 1653 2228
    BRAWH20055330 259 1507 . . . 1911 2229
    BRAWH20055780 260 354 . . . 953 2230
    BRAWH20058120 261  896 . . . 1501 2231
    BRAWH20063010 262 1839 . . . 2579 2232
    BRAWH20078080 263 161 . . . 745 2233
    BRAWH20078620 264  99 . . . 470 2234
    BRAWH20080580 265  35 . . . 1000 2235
    BRAWH20082550 266 2191 . . . 2670 2236
    BRAWH20082920 267 1579 . . . 2124 2237
    BRAWH20093040 268 1202 . . . 1855 2238
    BRAWH20093070 269  469 . . . 1569 2239
    BRAWH20094900 270  712 . . . 2166 2240
    BRAWH20095900 271  247 . . . 2178 2241
    BRAWH20173790 272  634 . . . 1428 2242
    BRAWH20174330 273 2532 . . . 3272 2243
    BRAWH20175230 274 1119 . . . 1451 2244
    BRAWH20175340 275  88 . . . 504 2245
    BRAWH20176850 276  32 . . . 2203 2246
    BRAWH20182670 277 2751 . . . 3059 2247
    BRAWH20183170 278 106 . . . 909 2248
    BRAWH20185260 279  204 . . . 1946 2249
    BRAWH20185270 280  15 . . . 869 2250
    BRAWH20186010 281  886 . . . 1389 2251
    BRAWH20188750 282  21 . . . 824 2252
    BRAWH20190530 283  410 . . . 1024 2253
    BRAWH20190550 284  55 . . . 1533 2254
    BRAWH20191980 285 1426 . . . 2172 2255
    BRCAN10000760 286  548 . . . 1885 2256
    BRCAN10001050 287 388 . . . 828 2257
    BRCAN10001680 288 519 . . . 998 2258
    BRCAN20001480 289 114 . . . 449 2259
    BRCAN20004180 290  8 . . . 331 2260
    BRCAN20005230 291  63 . . . 590 2261
    BRCAN20005410 292  52 . . . 1335 2262
    BRCOC10000400 293  11 . . . 3664 2263
    BRCOC20000470 294  283 . . . 1851 2264
    BRCOC20003600 295  163 . . . 1455 2265
    BRHIP10000720 296  4 . . . 312 2266
    BRHIP10001040 297  76 . . . 1317 2267
    BRHIP20000210 298  7 . . . 378 2268
    BRHIP20003590 299  618 . . . 1238 2269
    BRHIP20005060 300  756 . . . 1178 2270
    BRSSN20001970 301  89 . . . 526 2271
    BRSSN20005610 302    174 . . . >2375 2272
    BRSSN20005660 303   2089 . . . >2535 2273
    BRSSN20066440 304  248 . . . 1474 2274
    BRSSN20074640 305 257 . . . 985 2275
    BRSSN20091190 306 1214 . . . 2002 2276
    BRSSN20092440 307  4 . . . 396 2277
    BRSSN20093890 308  94 . . . 717 2278
    CD34C20001750 309  10 . . . 840 2279
    CTONG10000090 310 2551 . . . 2991 2280
    CTONG20000340 311  856 . . . 1929 2281
    CTONG20002790 312 373 . . . 708 2282
    CTONG20004110 313  74 . . . 3079 2283
    CTONG20004520 314 146 . . . 772 2284
    CTONG20007660 315  192 . . . 1448 2285
    CTONG20008190 316 1313 . . . 1789 2286
    CTONG20008460 317 1034 . . . 1849 2287
    CTONG20015240 318 134 . . . 874 2288
    CTONG20017490 319  346 . . . 2235 2289
    CTONG20020660 320 219 . . . 635 2290
    CTONG20020950 321  24 . . . 3257 2291
    CTONG20027660 322 103 . . . 942 2292
    CTONG20029030 323  102 . . . 2492 2293
    CTONG20030280 324  219 . . . 2891 2294
    CTONG20031150 325 2175 . . . 2546 2295
    CTONG20031890 326   8 . . . 1705 2296
    CTONG20032930 327  352 . . . 3102 2297
    CTONG20033500 328 1683 . . . 2018 2298
    CTONG20033610 329    404 . . . >3203 2299
    CTONG20033750 330  95 . . . 1999 2300
    CTONG20035240 331  234 . . . 2687 2301
    CTONG20036800 332 432 . . . 770 2302
    CTONG20036990 333 1568 . . . 2347 2303
    CTONG20039370 334 114 . . . 470 2304
    CTONG20041150 335  406 . . . 1164 2305
    CTONG20041260 336  477 . . . 2276 2306
    CTONG20042640 337   6 . . . 2381 2307
    CTONG20044230 338 1199 . . . 3205 2308
    CTONG20044870 339  17 . . . 2554 2309
    CTONG20045500 340  226 . . . 1950 2310
    CTONG20046690 341 385 . . . 840 2311
    CTONG20049480 342    216 . . . >3268 2312
    CTONG20050490 343 428 . . . 859 2313
    CTONG20051100 344  48 . . . 419 2314
    CTONG20051450 345 1239 . . . 1823 2315
    CTONG20052780 346  976 . . . 1656 2316
    CTONG20053990 347   2233 . . . >2955 2317
    CTONG20055670 348 2306 . . . 2620 2318
    CTONG20055850 349  506 . . . 1246 2319
    CTONG20056150 350  95 . . . 1150 2320
    CTONG20057750 351 2355 . . . 2849 2321
    CTONG20057950 352 3061 . . . 3420 2322
    CTONG20059130 353  109 . . . 2613 2323
    CTONG20060040 354  204 . . . 2630 2324
    CTONG20061290 355 226 . . . 819 2325
    CTONG20062730 356 307 . . . 687 2326
    CTONG20063770 357  108 . . . 3203 2327
    CTONG20063930 358  250 . . . 2700 2328
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    PROST20155370 1182  606 . . . 2255 3152
    PROST20156360 1183 1557 . . . 1898 3153
    PROST20159320 1184  67 . . . 567 3154
    PROST20168600 1185  336 . . . 1700 3155
    PUAEN10000650 1186 341 . . . 943 3156
    PUAEN10000870 1187 1676 . . . 2029 3157
    PUAEN10001640 1188  332 . . . 1138 3158
    PUAEN20000800 1189  327 . . . 1811 3159
    PUAEN20001520 1190  155 . . . 1243 3160
    PUAEN20002470 1191   3 . . . 2417 3161
    PUAEN20003120 1192  93 . . . 2216 3162
    SALGL10001070 1193  89 . . . 997 3163
    SKMUS20006790 1194  389 . . . 1330 3164
    SKMUS20007260 1195    47 . . . >1320 3165
    SKMUS20008730 1196  91 . . . 1407 3166
    SKMUS20017400 1197  84 . . . 815 3167
    SKMUS20020770 1198 179 . . . 781 3168
    SKMUS20026340 1199  57 . . . 1202 3169
    SKMUS20040440 1200  27 . . . 1091 3170
    SKMUS20064810 1201  91 . . . 459 3171
    SKMUS20073150 1202    17 . . . >822 3172
    SKMUS20073590 1203 438 . . . 824 3173
    SKMUS20079150 1204  165 . . . 1235 3174
    SKMUS20091900 1205  57 . . . 359 3175
    SKNMC10001230 1206  87 . . . 1814 3176
    SKNMC20006350 1207  326 . . . 1738 3177
    SKNSH10001010 1208 1189 . . . 1530 3178
    SKNSH20007160 1209 113 . . . 562 3179
    SKNSH20009710 1210  71 . . . 622 3180
    SKNSH20030640 1211 1635 . . . 2090 3181
    SKNSH20040390 1212 246 . . . 911 3182
    SKNSH20052400 1213  926 . . . 2017 3183
    SKNSH20057920 1214  369 . . . 1352 3184
    SKNSH20068220 1215  504 . . . 1235 3185
    SKNSH20094350 1216  70 . . . 591 3186
    SMINT20000070 1217  752 . . . 1858 3187
    SMINT20002320 1218  607 . . . 1761 3188
    SMINT20006020 1219 1215 . . . 2348 3189
    SMINT20006090 1220  75 . . . 602 3190
    SMINT20007470 1221  154 . . . 1650 3191
    SMINT20008110 1222  784 . . . 1557 3192
    SMINT20011830 1223  34 . . . 447 3193
    SMINT20011950 1224  732 . . . 2006 3194
    SMINT20012220 1225 239 . . . 616 3195
    SMINT20013970 1226 1117 . . . 1686 3196
    SMINT20014610 1227 287 . . . 814 3197
    SMINT20016150 1228  911 . . . 1675 3198
    SMINT20017310 1229 1220 . . . 1561 3199
    SMINT20021260 1230 1066 . . . 1407 3200
    SMINT20023110 1231 1696 . . . 2073 3201
    SMINT20024140 1232  31 . . . 555 3202
    SMINT20026200 1233  323 . . . 2170 3203
    SMINT20028800 1234  476 . . . 1696 3204
    SMINT20028840 1235  89 . . . 823 3205
    SMINT20030740 1236  172 . . . 1833 3206
    SMINT20031280 1237  542 . . . 1489 3207
    SMINT20035050 1238  227 . . . 2149 3208
    SMINT20035510 1239    168 . . . >1891 3209
    SMINT20036440 1240  207 . . . 2084 3210
    SMINT20038660 1241  289 . . . 1449 3211
    SMINT20039050 1242    175 . . . >2338 3212
    SMINT20043390 1243 1465 . . . 2094 3213
    SMINT20044140 1244  30 . . . 1718 3214
    SMINT20044730 1245  45 . . . 1787 3215
    SMINT20045470 1246 1156 . . . 1539 3216
    SMINT20045830 1247  287 . . . 1882 3217
    SMINT20045890 1248  893 . . . 1372 3218
    SMINT20047290 1249  2 . . . 637 3219
    SMINT20048720 1250   1834 . . . >2374 3220
    SMINT20049920 1251 1384 . . . 1860 3221
    SMINT20052130 1252 271 . . . 891 3222
    SMINT20054050 1253  361 . . . 1839 3223
    SMINT20056230 1254  73 . . . 1674 3224
    SMINT20056240 1255 1108 . . . 1533 3225
    SMINT20062050 1256  75 . . . 1964 3226
    SMINT20067080 1257  138 . . . 2075 3227
    SMINT20070620 1258  44 . . . 445 3228
    SMINT20074330 1259  71 . . . 532 3229
    SMINT20077920 1260  843 . . . 1166 3230
    SMINT20077960 1261 1010 . . . 2467 3231
    SMINT20081330 1262 250 . . . 618 3232
    SMINT20083290 1263  80 . . . 1606 3233
    SMINT20084910 1264 664 . . . 987 3234
    SMINT20085310 1265 129 . . . 500 3235
    SMINT20085450 1266  66 . . . 437 3236
    SMINT20086250 1267 1958 . . . 2287 3237
    SMINT20086720 1268  233 . . . 1003 3238
    SMINT20088440 1269  31 . . . 438 3239
    SMINT20088690 1270  26 . . . 580 3240
    SMINT20089210 1271 1259 . . . 1672 3241
    SMINT20089600 1272  241 . . . 1335 3242
    SMINT20091190 1273  290 . . . 1765 3243
    SMINT20092120 1274  33 . . . 416 3244
    SMINT20092160 1275 439 . . . 780 3245
    SMINT20093630 1276 1822 . . . 2241 3246
    SMINT20094150 1277 511 . . . 966 3247
    SMINT20094680 1278  36 . . . 452 3248
    SPLEN20005160 1279 2342 . . . 2659 3249
    SPLEN20005370 1280 1497 . . . 1856 3250
    SPLEN20006950 1281  702 . . . 1343 3251
    SPLEN20011350 1282 1127 . . . 1537 3252
    SPLEN20012450 1283 134 . . . 442 3253
    SPLEN20015030 1284 376 . . . 945 3254
    SPLEN20015100 1285 1367 . . . 2137 3255
    SPLEN20016500 1286 328 . . . 816 3256
    SPLEN20017610 1287  940 . . . 1314 3257
    SPLEN20017810 1288 101 . . . 556 3258
    SPLEN20019120 1289 176 . . . 487 3259
    SPLEN20020530 1290 358 . . . 762 3260
    SPLEN20023430 1291 1067 . . . 1426 3261
    SPLEN20023540 1292  644 . . . 1903 3262
    SPLEN20023850 1293    467 . . . >1879 3263
    SPLEN20024190 1294  319 . . . 1368 3264
    SPLEN20024510 1295 1070 . . . 1423 3265
    SPLEN20024620 1296   3 . . . 1514 3266
    SPLEN20024770 1297  134 . . . 2353 3267
    SPLEN20024930 1298 1150 . . . 3069 3268
    SPLEN20029170 1299  67 . . . 750 3269
    SPLEN20036780 1300 1432 . . . 1752 3270
    SPLEN20039180 1301  359 . . . 1534 3271
    SPLEN20040780 1302 1675 . . . 2346 3272
    SPLEN20041810 1303  801 . . . 1142 3273
    SPLEN20042200 1304 1123 . . . 1935 3274
    SPLEN20043430 1305 224 . . . 565 3275
    SPLEN20043460 1306  55 . . . 1899 3276
    SPLEN20043680 1307 1337 . . . 2371 3277
    SPLEN20045550 1308   5 . . . 1513 3278
    SPLEN20048800 1309 2038 . . . 2352 3279
    SPLEN20049840 1310  82 . . . 3378 3280
    SPLEN20050090 1311  418 . . . 2202 3281
    SPLEN20051420 1312  685 . . . 1983 3282
    SPLEN20054160 1313  186 . . . 2069 3283
    SPLEN20054500 1314  667 . . . 1443 3284
    SPLEN20055600 1315  146 . . . 1033 3285
    SPLEN20057830 1316  507 . . . 1163 3286
    SPLEN20057900 1317 1883 . . . 2431 3287
    SPLEN20058180 1318  803 . . . 1120 3288
    SPLEN20059270 1319  162 . . . 1586 3289
    SPLEN20062830 1320 282 . . . 785 3290
    SPLEN20063250 1321  315 . . . 1535 3291
    SPLEN20063890 1322 133 . . . 996 3292
    SPLEN20067010 1323   2702 . . . >3023 3293
    SPLEN20071820 1324  876 . . . 1592 3294
    SPLEN20073500 1325  174 . . . 2210 3295
    SPLEN20073880 1326  220 . . . 2595 3296
    SPLEN20076190 1327  20 . . . 331 3297
    SPLEN20076470 1328  575 . . . 1714 3298
    SPLEN20080070 1329   5 . . . 1339 3299
    SPLEN20081640 1330  946 . . . 1308 3300
    SPLEN20085910 1331 1084 . . . 1434 3301
    SPLEN20087370 1332 2670 . . . 3098 3302
    SPLEN20087860 1333 255 . . . 755 3303
    SPLEN20090880 1334 1742 . . . 2194 3304
    SPLEN20098030 1335  268 . . . 1077 3305
    SPLEN20100040 1336 101 . . . 862 3306
    SPLEN20101950 1337  122 . . . 1198 3307
    SPLEN20104150 1338 1146 . . . 2219 3308
    SPLEN20104690 1339 661 . . . 990 3309
    SPLEN20105100 1340 1425 . . . 1859 3310
    SPLEN20108000 1341  887 . . . 1351 3311
    SPLEN20108460 1342 2254 . . . 2607 3312
    SPLEN20110180 1343  147 . . . 1292 3313
    SPLEN20110210 1344 1831 . . . 2271 3314
    SPLEN20110860 1345 1489 . . . 1887 3315
    SPLEN20111450 1346 2768 . . . 3208 3316
    SPLEN20114190 1347  154 . . . 1440 3317
    SPLEN20116720 1348   9 . . . 1583 3318
    SPLEN20117580 1349  218 . . . 1240 3319
    SPLEN20118050 1350  145 . . . 1122 3320
    SPLEN20121790 1351  569 . . . 1054 3321
    SPLEN20125230 1352  971 . . . 1324 3322
    SPLEN20126110 1353 254 . . . 991 3323
    SPLEN20135030 1354  40 . . . 1848 3324
    SPLEN20136700 1355 1296 . . . 1628 3325
    SPLEN20136730 1356 1312 . . . 1644 3326
    SPLEN20137530 1357 2676 . . . 3221 3327
    SPLEN20138600 1358 1166 . . . 1582 3328
    SPLEN20139100 1359  63 . . . 1532 3329
    SPLEN20139360 1360  763 . . . 1827 3330
    SPLEN20175920 1361 1123 . . . 1590 3331
    SPLEN20176130 1362  16 . . . 549 3332
    SPLEN20177400 1363 1078 . . . 1431 3333
    SPLEN20180980 1364 410 . . . 823 3334
    SPLEN20181570 1365    214 . . . >2609 3335
    SPLEN20182850 1366 168 . . . 659 3336
    SPLEN20182990 1367  55 . . . 1881 3337
    SPLEN20183020 1368 265 . . . 723 3338
    SPLEN20183950 1369 402 . . . 746 3339
    SPLEN20187490 1370    98 . . . >2458 3340
    SPLEN20190080 1371  914 . . . 1342 3341
    SPLEN20190430 1372    884 . . . >1942 3342
    SPLEN20190770 1373  97 . . . 771 3343
    SPLEN20191020 1374  140 . . . 1426 3344
    SPLEN20192570 1375 325 . . . 654 3345
    SPLEN20193230 1376 253 . . . 588 3346
    SPLEN20193490 1377 321 . . . 854 3347
    SPLEN20193750 1378  845 . . . 1306 3348
    SPLEN20193790 1379  290 . . . 2278 3349
    SPLEN20195710 1380  64 . . . 516 3350
    SPLEN20197090 1381  11 . . . 550 3351
    SPLEN20197740 1382  2 . . . 499 3352
    SPLEN20197930 1383    803 . . . >1625 3353
    SPLEN20198390 1384  14 . . . 1873 3354
    SPLEN20199850 1385  575 . . . 1009 3355
    SPLEN20200070 1386 353 . . . 655 3356
    SPLEN20200340 1387 1047 . . . 1814 3357
    SPLEN20201830 1388  143 . . . 1177 3358
    SPLEN20203590 1389 160 . . . 471 3359
    SPLEN20204670 1390  6 . . . 311 3360
    SPLEN20205120 1391  682 . . . 1542 3361
    TESOP10000350 1392 1646 . . . 2101 3362
    TESOP10001600 1393  282 . . . 1352 3363
    TESTI10000190 1394  84 . . . 2042 3364
    TESTI10000850 1395  925 . . . 1311 3365
    TESTI10001570 1396  141 . . . 1919 3366
    TESTI20004310 1397  55 . . . 2484 3367
    TESTI20005980 1398   1350 . . . >1866 3368
    TESTI20006160 1399  53 . . . 1720 3369
    TESTI20006830 1400  313 . . . 1719 3370
    TESTI20012080 1401  89 . . . 1867 3371
    TESTI20012360 1402 178 . . . 594 3372
    TESTI20016970 1403  133 . . . 1842 3373
    TESTI20019590 1404 210 . . . 752 3374
    TESTI20028020 1405  201 . . . 1298 3375
    TESTI20029100 1406 1743 . . . 2147 3376
    TESTI20030200 1407  94 . . . 2091 3377
    TESTI20030440 1408  60 . . . 1931 3378
    TESTI20030610 1409  547 . . . 1371 3379
    TESTI20031310 1410  889 . . . 2235 3380
    TESTI20031410 1411  201 . . . 1655 3381
    TESTI20032770 1412  163 . . . 1002 3382
    TESTI20034750 1413 472 . . . 804 3383
    TESTI20035330 1414  13 . . . 558 3384
    TESTI20035790 1415  16 . . . 2163 3385
    TESTI20038240 1416  163 . . . 2502 3386
    TESTI20040850 1417  52 . . . 669 3387
    TESTI20041630 1418  330 . . . 1526 3388
    TESTI20043130 1419 410 . . . 715 3389
    TESTI20043180 1420  68 . . . 2515 3390
    TESTI20043220 1421 1496 . . . 1957 3391
    TESTI20043910 1422  37 . . . 1728 3392
    TESTI20043990 1423  311 . . . 1153 3393
    TESTI20044900 1424  234 . . . 1595 3394
    TESTI20045390 1425  156 . . . 2108 3395
    TESTI20045740 1426 199 . . . 549 3396
    TESTI20046110 1427  24 . . . 1826 3397
    TESTI20046490 1428  554 . . . 2542 3398
    TESTI20046540 1429  123 . . . 2309 3399
    TESTI20046870 1430  278 . . . 1645 3400
    TESTI20046890 1431  276 . . . 2702 3401
    TESTI20047370 1432   2 . . . 2134 3402
    TESTI20047930 1433  239 . . . 1843 3403
    TESTI20049060 1434 1191 . . . 1784 3404
    TESTI20049410 1435  281 . . . 2170 3405
    TESTI20049990 1436 355 . . . 915 3406
    TESTI20050170 1437 314 . . . 808 3407
    TESTI20050400 1438 111 . . . 440 3408
    TESTI20050720 1439  68 . . . 1621 3409
    TESTI20051200 1440 1561 . . . 2145 3410
    TESTI20051730 1441  183 . . . 1943 3411
    TESTI20052670 1442  759 . . . 1910 3412
    TESTI20053070 1443  98 . . . 1285 3413
    TESTI20053260 1444 456 . . . 842 3414
    TESTI20053780 1445  176 . . . 1948 3415
    TESTI20053800 1446  42 . . . 1694 3416
    TESTI20053950 1447    528 . . . >1782 3417
    TESTI20054700 1448  19 . . . 1956 3418
    TESTI20055680 1449  53 . . . 1510 3419
    TESTI20055880 1450  127 . . . 1644 3420
    TESTI20056030 1451  543 . . . 1658 3421
    TESTI20057200 1452 279 . . . 611 3422
    TESTI20057430 1453  131 . . . 1858 3423
    TESTI20057590 1454  37 . . . 1062 3424
    TESTI20057840 1455  180 . . . 1271 3425
    TESTI20057880 1456  39 . . . 1697 3426
    TESTI20058350 1457  25 . . . 1368 3427
    TESTI20058920 1458  108 . . . 1088 3428
    TESTI20059080 1459 2134 . . . 3069 3429
    TESTI20059330 1460 540 . . . 845 3430
    TESTI20059370 1461  655 . . . 1137 3431
    TESTI20059480 1462  52 . . . 1362 3432
    TESTI20059790 1463  203 . . . 1336 3433
    TESTI20059810 1464    324 . . . >1914 3434
    TESTI20060080 1465 172 . . . 858 3435
    TESTI20060150 1466  383 . . . 1663 3436
    TESTI20060350 1467  81 . . . 1427 3437
    TESTI20060450 1468 1306 . . . 1752 3438
    TESTI20060830 1469  54 . . . 2543 3439
    TESTI20061090 1470 382 . . . 798 3440
    TESTI20061200 1471  382 . . . 1938 3441
    TESTI20062120 1472  37 . . . 1632 3442
    TESTI20062180 1473  169 . . . 1413 3443
    TESTI20062580 1474  863 . . . 1165 3444
    TESTI20063330 1475 1334 . . . 1678 3445
    TESTI20063410 1476 2175 . . . 2501 3446
    TESTI20063600 1477 1399 . . . 1809 3447
    TESTI20064370 1478  201 . . . 1706 3448
    TESTI20064530 1479  68 . . . 2737 3449
    TESTI20064650 1480  353 . . . 2542 3450
    TESTI20064990 1481  733 . . . 1290 3451
    TESTI20065650 1482  374 . . . 1609 3452
    TESTI20066150 1483  98 . . . 2473 3453
    TESTI20066170 1484  143 . . . 1309 3454
    TESTI20066280 1485 100 . . . 879 3455
    TESTI20066330 1486  26 . . . 1528 3456
    TESTI20066590 1487 306 . . . 740 3457
    TESTI20066650 1488  415 . . . 1362 3458
    TESTI20067350 1489  342 . . . 1073 3459
    TESTI20067440 1490  196 . . . 1887 3460
    TESTI20067480 1491  127 . . . 1758 3461
    TESTI20068530 1492  791 . . . 1369 3462
    TESTI20068790 1493   1033 . . . >1738 3463
    TESTI20068940 1494    55 . . . >1867 3464
    TESTI20070400 1495  147 . . . 2300 3465
    TESTI20070740 1496  743 . . . 1480 3466
    TESTI20071130 1497  224 . . . 1738 3467
    TESTI20071630 1498  38 . . . 727 3468
    TESTI20073460 1499  97 . . . 1584 3469
    TESTI20075240 1500  259 . . . 1686 3470
    TESTI20076570 1501  622 . . . 1110 3471
    TESTI20076920 1502  90 . . . 608 3472
    TESTI20079060 1503  105 . . . 2096 3473
    TESTI20079220 1504  54 . . . 2252 3474
    TESTI20079980 1505  62 . . . 1300 3475
    TESTI20080460 1506 1458 . . . 1787 3476
    TESTI20081890 1507  184 . . . 2520 3477
    TESTI20083890 1508 1102 . . . 1596 3478
    TESTI20084250 1509  386 . . . 2035 3479
    TESTI20085670 1510 1459 . . . 2001 3480
    TESTI20086840 1511  10 . . . 1488 3481
    TESTI20088840 1512  172 . . . 1587 3482
    TESTI20089290 1513  26 . . . 421 3483
    TESTI20090180 1514  527 . . . 1657 3484
    TESTI20090970 1515  548 . . . 2308 3485
    TESTI20091360 1516  745 . . . 1230 3486
    TESTI20092170 1517  882 . . . 1256 3487
    TESTI20093900 1518  265 . . . 1791 3488
    TESTI20094620 1519 1897 . . . 2319 3489
    TESTI20095200 1520  94 . . . 1149 3490
    TESTI20095440 1521 1134 . . . 1496 3491
    TESTI20095770 1522    278 . . . >2225 3492
    TESTI20095880 1523  144 . . . 1775 3493
    TESTI20097270 1524 157 . . . 693 3494
    TESTI20099350 1525    123 . . . >1773 3495
    TESTI20100090 1526 1020 . . . 2057 3496
    TESTI20102390 1527 1873 . . . 2247 3497
    TESTI20103690 1528  71 . . . 1048 3498
    TESTI20104090 1529  364 . . . 1716 3499
    TESTI20105130 1530  320 . . . 1966 3500
    TESTI20105910 1531  151 . . . 2265 3501
    TESTI20106170 1532  235 . . . 1338 3502
    TESTI20106820 1533 1191 . . . 1604 3503
    TESTI20107240 1534  163 . . . 2844 3504
    TESTI20107320 1535 377 . . . 787 3505
    TESTI20107340 1536 1229 . . . 1723 3506
    TESTI20108060 1537 371 . . . 925 3507
    TESTI20112540 1538  148 . . . 1554 3508
    TESTI20112860 1539  285 . . . 1829 3509
    TESTI20113150 1540  374 . . . 1042 3510
    TESTI20113940 1541 1185 . . . 1598 3511
    TESTI20114480 1542  161 . . . 2032 3512
    TESTI20116050 1543  218 . . . 1756 3513
    TESTI20116120 1544  17 . . . 1276 3514
    TESTI20117500 1545 140 . . . 508 3515
    TESTI20118460 1546  69 . . . 1580 3516
    TESTI20120500 1547 135 . . . 926 3517
    TESTI20120900 1548  60 . . . 665 3518
    TESTI20121040 1549   8 . . . 1525 3519
    TESTI20121710 1550  278 . . . 1543 3520
    TESTI20122070 1551  145 . . . 1359 3521
    TESTI20122440 1552  25 . . . 465 3522
    TESTI20124440 1553 469 . . . 801 3523
    TESTI20125280 1554  371 . . . 1363 3524
    TESTI20125440 1555 342 . . . 671 3525
    TESTI20125920 1556  31 . . . 1680 3526
    TESTI20126280 1557  169 . . . 2562 3527
    TESTI20130530 1558  298 . . . 1692 3528
    TESTI20131440 1559  223 . . . 1278 3529
    TESTI20132310 1560 204 . . . 713 3530
    TESTI20132680 1561 1011 . . . 1448 3531
    TESTI20134010 1562  334 . . . 1464 3532
    TESTI20134270 1563  59 . . . 601 3533
    TESTI20134680 1564  324 . . . 2726 3534
    TESTI20134970 1565  197 . . . 1873 3535
    TESTI20136010 1566    152 . . . >1415 3536
    TESTI20140970 1567 376 . . . 801 3537
    TESTI20142480 1568 1466 . . . 1939 3538
    TESTI20142540 1569 1231 . . . 1593 3539
    TESTI20143180 1570  201 . . . 1946 3540
    TESTI20144390 1571  776 . . . 1552 3541
    TESTI20145780 1572 1315 . . . 1746 3542
    TESTI20148380 1573  32 . . . 2680 3543
    TESTI20149880 1574 581 . . . 982 3544
    TESTI20150420 1575  221 . . . 1162 3545
    TESTI20150920 1576  142 . . . 1713 3546
    TESTI20151050 1577 1290 . . . 1736 3547
    TESTI20151800 1578  671 . . . 1099 3548
    TESTI20152490 1579  717 . . . 1226 3549
    TESTI20153310 1580  151 . . . 1317 3550
    TESTI20154370 1581  192 . . . 1544 3551
    TESTI20159380 1582  852 . . . 1679 3552
    TESTI20161010 1583  33 . . . 539 3553
    TESTI20162780 1584  607 . . . 1299 3554
    TESTI20162980 1585  224 . . . 1414 3555
    TESTI20164210 1586  526 . . . 1593 3556
    TESTI20165680 1587 154 . . . 552 3557
    TESTI20165990 1588 201 . . . 992 3558
    TESTI20166290 1589  351 . . . 2786 3559
    TESTI20166670 1590  754 . . . 1938 3560
    TESTI20167580 1591   1152 . . . >1543 3561
    TESTI20168880 1592 201 . . . 524 3562
    TESTI20169500 1593  280 . . . 1674 3563
    TESTI20170170 1594  199 . . . 1530 3564
    TESTI20170280 1595  1 . . . 696 3565
    TESTI20170690 1596  61 . . . 474 3566
    TESTI20170890 1597  882 . . . 1238 3567
    TESTI20171070 1598 1088 . . . 1501 3568
    TESTI20173050 1599  724 . . . 1218 3569
    TESTI20173110 1600 1194 . . . 1586 3570
    TESTI20173960 1601  376 . . . 1764 3571
    TESTI20175370 1602  828 . . . 1724 3572
    TESTI20176450 1603  1 . . . 996 3573
    TESTI20179230 1604  162 . . . 1709 3574
    TESTI20179510 1605   1702 . . . >2042 3575
    TESTI20180600 1606 162 . . . 857 3576
    TESTI20182210 1607  736 . . . 1182 3577
    TESTI20182760 1608  266 . . . 1390 3578
    TESTI20183680 1609    778 . . . >1927 3579
    TESTI20184280 1610    35 . . . >1732 3580
    TESTI20184750 1611  899 . . . 2116 3581
    TESTI20184760 1612  161 . . . 1741 3582
    TESTI20184820 1613 189 . . . 722 3583
    TESTI20186110 1614  221 . . . 1606 3584
    TESTI20192570 1615 109 . . . 687 3585
    TESTI20193080 1616  149 . . . 2194 3586
    TESTI20193520 1617  311 . . . 1375 3587
    TESTI20194880 1618  616 . . . 1554 3588
    TESTI20196690 1619 271 . . . 945 3589
    TESTI20196970 1620  789 . . . 1565 3590
    TESTI20197030 1621  263 . . . 1717 3591
    TESTI20197290 1622  643 . . . 1314 3592
    TESTI20197600 1623 100 . . . 909 3593
    TESTI20198540 1624  21 . . . 1553 3594
    TESTI20198600 1625  909 . . . 1328 3595
    TESTI20199110 1626  622 . . . 1617 3596
    TESTI20199980 1627  764 . . . 1102 3597
    TESTI20200120 1628 661 . . . 966 3598
    TESTI20200840 1629 378 . . . 818 3599
    TESTI20201760 1630  22 . . . 603 3600
    TESTI20202830 1631 631 . . . 972 3601
    TESTI20204260 1632  714 . . . 1406 3602
    TESTI20205100 1633  270 . . . 1763 3603
    TESTI20205150 1634 1286 . . . 1663 3604
    TESTI20205250 1635  32 . . . 1888 3605
    TESTI20207170 1636  1 . . . 795 3606
    TESTI20209050 1637  269 . . . 1900 3607
    TESTI20210030 1638 328 . . . 675 3608
    TESTI20210570 1639  280 . . . 1362 3609
    TESTI20211380 1640 372 . . . 848 3610
    TESTI20212970 1641  93 . . . 2102 3611
    TESTI20214630 1642  690 . . . 1106 3612
    TESTI20215310 1643 294 . . . 899 3613
    TESTI20219110 1644  982 . . . 1344 3614
    TESTI20219390 1645 253 . . . 573 3615
    TESTI20220230 1646 116 . . . 967 3616
    TESTI20221790 1647  109 . . . 1830 3617
    TESTI20222030 1648  277 . . . 2277 3618
    TESTI20222460 1649  162 . . . 1889 3619
    TESTI20223380 1650 322 . . . 831 3620
    TESTI20226520 1651  178 . . . 1392 3621
    TESTI20227380 1652  20 . . . 1747 3622
    TESTI20228120 1653  31 . . . 858 3623
    TESTI20228740 1654  607 . . . 1026 3624
    TESTI20244220 1655  757 . . . 2448 3625
    TESTI20244430 1656  17 . . . 1444 3626
    TESTI20244460 1657  684 . . . 1511 3627
    TESTI20244730 1658  127 . . . 1044 3628
    TESTI20245600 1659  255 . . . 1523 3629
    TESTI20245860 1660  684 . . . 1058 3630
    TESTI20246410 1661 1513 . . . 1818 3631
    TESTI20246480 1662  380 . . . 1399 3632
    TESTI20247440 1663 425 . . . 907 3633
    TESTI20248850 1664   3 . . . 1829 3634
    TESTI20249360 1665  600 . . . 1565 3635
    TESTI20250220 1666  63 . . . 2015 3636
    TESTI20250630 1667  482 . . . 1690 3637
    TESTI20251440 1668  42 . . . 1271 3638
    TESTI20251610 1669  430 . . . 1218 3639
    TESTI20251740 1670  730 . . . 1104 3640
    TESTI20252690 1671 1182 . . . 2138 3641
    TESTI20254030 1672  363 . . . 1958 3642
    TESTI20254090 1673  878 . . . 1360 3643
    TESTI20254480 1674  320 . . . 1390 3644
    TESTI20254990 1675  693 . . . 1799 3645
    TESTI20255460 1676  152 . . . 2710 3646
    TESTI20256560 1677    169 . . . >2257 3647
    TESTI20257910 1678  457 . . . 1311 3648
    TESTI20258720 1679  38 . . . 1630 3649
    TESTI20259110 1680  486 . . . 1805 3650
    TESTI20259200 1681  227 . . . 1369 3651
    TESTI20260140 1682 1113 . . . 1421 3652
    TESTI20260640 1683   6 . . . 1109 3653
    TESTI20261040 1684  14 . . . 970 3654
    TESTI20261160 1685 257 . . . 868 3655
    TESTI20261680 1686 1422 . . . 1901 3656
    TESTI20262150 1687  315 . . . 2765 3657
    TESTI20262940 1688  255 . . . 1574 3658
    TESTI20264530 1689  150 . . . 1580 3659
    TESTI20264910 1690 1638 . . . 2378 3660
    TESTI20265150 1691 1023 . . . 1409 3661
    TESTI20265340 1692  965 . . . 1552 3662
    TESTI20265890 1693  994 . . . 1308 3663
    TESTI20266050 1694  116 . . . 1522 3664
    TESTI20268240 1695  70 . . . 1638 3665
    TESTI20269250 1696    17 . . . >1926 3666
    TESTI20269360 1697  682 . . . 1005 3667
    TESTI20270130 1698  99 . . . 512 3668
    TESTI20271790 1699  101 . . . 1822 3669
    TESTI20272380 1700 121 . . . 492 3670
    TESTI20274960 1701  619 . . . 1716 3671
    TESTI20277300 1702  263 . . . 1600 3672
    TESTI20278280 1703  80 . . . 607 3673
    TESTI20282420 1704  52 . . . 528 3674
    TESTI20282530 1705  699 . . . 1985 3675
    TESTI20282900 1706  30 . . . 341 3676
    TESTI20284260 1707  29 . . . 493 3677
    TESTI20285230 1708 1710 . . . 2366 3678
    TESTI20286590 1709  519 . . . 1121 3679
    TESTI20287760 1710  775 . . . 2634 3680
    THYMU10004280 1711 617 . . . 988 3681
    THYMU20006020 1712  608 . . . 1387 3682
    THYMU20007020 1713 1755 . . . 2111 3683
    THYMU20007750 1714 1077 . . . 1499 3684
    THYMU20008000 1715 1506 . . . 1955 3685
    THYMU20009460 1716 1334 . . . 1723 3686
    THYMU20009500 1717  717 . . . 2117 3687
    THYMU20009710 1718 247 . . . 762 3688
    THYMU20010180 1719 191 . . . 634 3689
    THYMU20010710 1720  850 . . . 1164 3690
    THYMU20012020 1721 1160 . . . 1561 3691
    THYMU20012560 1722  47 . . . 517 3692
    THYMU20013250 1723  131 . . . 1309 3693
    THYMU20013810 1724 196 . . . 927 3694
    THYMU20014430 1725 1280 . . . 1678 3695
    THYMU20017270 1726  16 . . . 660 3696
    THYMU20018250 1727 1205 . . . 2122 3697
    THYMU20018390 1728  237 . . . 1373 3698
    THYMU20019000 1729 405 . . . 758 3699
    THYMU20019260 1730 317 . . . 736 3700
    THYMU20020370 1731 1332 . . . 1733 3701
    THYMU20020800 1732  600 . . . 1196 3702
    THYMU20021090 1733  211 . . . 1281 3703
    THYMU20021540 1734  100 . . . 1578 3704
    THYMU20023560 1735 1429 . . . 1884 3705
    THYMU20024500 1736  199 . . . 1584 3706
    THYMU20025480 1737 1362 . . . 1751 3707
    THYMU20026950 1738  9 . . . 920 3708
    THYMU20028150 1739  233 . . . 1222 3709
    THYMU20028410 1740  10 . . . 1086 3710
    THYMU20029830 1741  46 . . . 456 3711
    THYMU20030460 1742  453 . . . 1175 3712
    THYMU20030690 1743 1658 . . . 2269 3713
    THYMU20031330 1744  90 . . . 569 3714
    THYMU20032820 1745  250 . . . 1176 3715
    THYMU20034400 1746  791 . . . 1123 3716
    THYMU20034790 1747 120 . . . 452 3717
    THYMU20036500 1748  56 . . . 1657 3718
    THYMU20039320 1749  584 . . . 1339 3719
    THYMU20043440 1750 1301 . . . 1615 3720
    THYMU20043560 1751 292 . . . 621 3721
    THYMU20044100 1752 1800 . . . 2228 3722
    THYMU20044520 1753 1387 . . . 1899 3723
    THYMU20046350 1754 1863 . . . 2351 3724
    THYMU20046770 1755 321 . . . 671 3725
    THYMU20049060 1756 172 . . . 732 3726
    THYMU20050010 1757  206 . . . 1681 3727
    THYMU20051340 1758  886 . . . 1209 3728
    THYMU20052460 1759 1300 . . . 1683 3729
    THYMU20052830 1760  92 . . . 1504 3730
    THYMU20054800 1761 479 . . . 880 3731
    THYMU20055450 1762 112 . . . 426 3732
    THYMU20055460 1763  20 . . . 361 3733
    THYMU20055740 1764  901 . . . 1341 3734
    THYMU20055760 1765 232 . . . 738 3735
    THYMU20058550 1766 1170 . . . 1493 3736
    THYMU20060480 1767   2046 . . . >2453 3737
    THYMU20062520 1768 299 . . . 655 3738
    THYMU20062610 1769  136 . . . 1953 3739
    THYMU20062770 1770  381 . . . 1199 3740
    THYMU20063650 1771 264 . . . 800 3741
    THYMU20064680 1772 253 . . . 621 3742
    THYMU20066660 1773  405 . . . 1487 3743
    THYMU20069130 1774 341 . . . 961 3744
    THYMU20069460 1775 231 . . . 575 3745
    THYMU20069650 1776  728 . . . 1036 3746
    THYMU20070250 1777  81 . . . 1703 3747
    THYMU20071120 1778  170 . . . 1792 3748
    THYMU20071460 1779 152 . . . 499 3749
    THYMU20072580 1780 1981 . . . 2286 3750
    THYMU20073070 1781  551 . . . 1225 3751
    THYMU20073080 1782  755 . . . 1198 3752
    THYMU20077250 1783  645 . . . 1241 3753
    THYMU20078020 1784 1290 . . . 1598 3754
    THYMU20078240 1785 1506 . . . 1838 3755
    THYMU20079690 1786 1049 . . . 1714 3756
    THYMU20080490 1787  57 . . . 398 3757
    THYMU20081110 1788  629 . . . 1246 3758
    THYMU20083390 1789 592 . . . 924 3759
    THYMU20083500 1790  744 . . . 1067 3760
    THYMU20083830 1791  155 . . . 1786 3761
    THYMU20084520 1792 286 . . . 597 3762
    THYMU20086430 1793  769 . . . 1077 3763
    THYMU20087270 1794  842 . . . 2008 3764
    THYMU20089170 1795 305 . . . 619 3765
    THYMU20089900 1796 1008 . . . 1421 3766
    THYMU20090230 1797 106 . . . 594 3767
    THYMU20091040 1798  728 . . . 1054 3768
    THYMU20095920 1799 1809 . . . 2378 3769
    THYMU20096580 1800 120 . . . 692 3770
    THYMU20097920 1801  95 . . . 2086 3771
    THYMU20098350 1802  99 . . . 1802 3772
    THYMU20099060 1803  80 . . . 1573 3773
    THYMU20100940 1804   8 . . . 2218 3774
    THYMU20104480 1805  39 . . . 1451 3775
    THYMU20106990 1806  673 . . . 1464 3776
    THYMU20110720 1807  372 . . . 1070 3777
    THYMU20112570 1808 117 . . . 455 3778
    THYMU20112590 1809  112 . . . 1827 3779
    THYMU20115380 1810 1507 . . . 1839 3780
    THYMU20115730 1811  943 . . . 1632 3781
    THYMU20117850 1812 1625 . . . 1948 3782
    THYMU20120240 1813 1239 . . . 3002 3783
    THYMU20120730 1814 1257 . . . 2459 3784
    THYMU20121040 1815  230 . . . 2323 3785
    THYMU20128910 1816  181 . . . 1185 3786
    THYMU20129020 1817   1545 . . . >2019 3787
    THYMU20130470 1818  87 . . . 1169 3788
    THYMU20134260 1819 1845 . . . 2171 3789
    THYMU20137050 1820  958 . . . 1341 3790
    THYMU20137570 1821 2113 . . . 2571 3791
    THYMU20139160 1822  69 . . . 686 3792
    THYMU20140510 1823 1312 . . . 1626 3793
    THYMU20143230 1824  575 . . . 2023 3794
    THYMU20145990 1825 1330 . . . 2262 3795
    THYMU20148010 1826 326 . . . 820 3796
    THYMU20149230 1827 581 . . . 925 3797
    THYMU20150190 1828 1516 . . . 1908 3798
    THYMU20151610 1829  218 . . . 1663 3799
    THYMU20153210 1830 1135 . . . 2340 3800
    THYMU20154790 1831 1220 . . . 1753 3801
    THYMU20157620 1832  771 . . . 1487 3802
    THYMU20163600 1833 1216 . . . 1650 3803
    THYMU20170080 1834  944 . . . 1399 3804
    THYMU20170230 1835  835 . . . 1941 3805
    THYMU20171580 1836  821 . . . 1150 3806
    THYMU20174490 1837  52 . . . 453 3807
    THYMU20174790 1838  29 . . . 370 3808
    THYMU20175260 1839  991 . . . 1452 3809
    THYMU20176010 1840  12 . . . 2039 3810
    THYMU20177070 1841 1059 . . . 1415 3811
    THYMU20178440 1842  81 . . . 1517 3812
    THYMU20181890 1843  102 . . . 1652 3813
    THYMU20184550 1844  171 . . . 1886 3814
    THYMU20185470 1845 161 . . . 817 3815
    THYMU20185650 1846  36 . . . 536 3816
    THYMU20187210 1847 190 . . . 507 3817
    THYMU20191970 1848  230 . . . 1597 3818
    TKIDN10000620 1849 1075 . . . 1419 3819
    TKIDN10001710 1850 1685 . . . 2365 3820
    TKIDN10001920 1851  98 . . . 793 3821
    TRACH20011010 1852  228 . . . 2033 3822
    TRACH20011540 1853 125 . . . 478 3823
    TRACH20012490 1854  83 . . . 1600 3824
    TRACH20021000 1855 234 . . . 854 3825
    TRACH20021380 1856  313 . . . 1890 3826
    TRACH20025370 1857  947 . . . 1456 3827
    TRACH20026640 1858  964 . . . 1557 3828
    TRACH20029880 1859  201 . . . 1607 3829
    TRACH20040390 1860  125 . . . 3319 3830
    TRACH20041090 1861 1254 . . . 1589 3831
    TRACH20043360 1862  30 . . . 2066 3832
    TRACH20044990 1863 209 . . . 790 3833
    TRACH20049500 1864  840 . . . 1166 3834
    TRACH20051590 1865  927 . . . 1247 3835
    TRACH20057200 1866 2082 . . . 2393 3836
    TRACH20058000 1867  187 . . . 1647 3837
    TRACH20073990 1868  98 . . . 454 3838
    TRACH20080810 1869   2073 . . . >2910 3839
    TRACH20081270 1870   1681 . . . >2025 3840
    TRACH20090060 1871  309 . . . 1781 3841
    TRACH20091070 1872  129 . . . 1841 3842
    TRACH20093400 1873  131 . . . 2251 3843
    TRACH20093480 1874  694 . . . 1092 3844
    TRACH20098510 1875  142 . . . 1944 3845
    TRACH20101590 1876 1660 . . . 2220 3846
    TRACH20104510 1877  144 . . . 1184 3847
    TRACH20108240 1878  36 . . . 791 3848
    TRACH20113020 1879  177 . . . 1352 3849
    TRACH20122980 1880  732 . . . 1562 3850
    TRACH20123870 1881 235 . . . 540 3851
    TRACH20124970 1882 109 . . . 486 3852
    TRACH20125620 1883  22 . . . 387 3853
    TRACH20129180 1884 1545 . . . 1898 3854
    TRACH20131230 1885  123 . . . 2939 3855
    TRACH20139280 1886  152 . . . 1474 3856
    TRACH20140180 1887 203 . . . 553 3857
    TRACH20143710 1888 1219 . . . 1998 3858
    TRACH20149500 1889 163 . . . 906 3859
    TRACH20149720 1890  187 . . . 1695 3860
    TRACH20149740 1891  864 . . . 1505 3861
    TRACH20158240 1892 254 . . . 796 3862
    TRACH20159390 1893 1618 . . . 1941 3863
    TRACH20160800 1894 1223 . . . 1531 3864
    TRACH20163470 1895  971 . . . 2356 3865
    TRACH20164100 1896 372 . . . 722 3866
    TRACH20164810 1897 1685 . . . 2104 3867
    TRACH20165330 1898  704 . . . 1102 3868
    TRACH20165540 1899  810 . . . 1514 3869
    TRACH20167090 1900  57 . . . 1148 3870
    TRACH20170860 1901  186 . . . 1625 3871
    TRACH20173680 1902  83 . . . 1597 3872
    TRACH20174980 1903  93 . . . 1088 3873
    TRACH20182780 1904 1669 . . . 2070 3874
    TRACH20185120 1905  13 . . . 339 3875
    TRACH20188350 1906  248 . . . 1015 3876
    TRACH20190460 1907  351 . . . 1526 3877
    UMVEN10001380 1908 2122 . . . 2436 3878
    UTERU10001060 1909 187 . . . 552 3879
    UTERU10001870 1910 1681 . . . 2031 3880
    UTERU20000230 1911 120 . . . 608 3881
    UTERU20000950 1912  240 . . . 1658 3882
    UTERU20011760 1913 1719 . . . 2090 3883
    UTERU20013890 1914 1544 . . . 1951 3884
    UTERU20016580 1915  25 . . . 1287 3885
    UTERU20026620 1916 1020 . . . 1556 3886
    UTERU20027360 1917 1624 . . . 1992 3887
    UTERU20029930 1918  82 . . . 1902 3888
    UTERU20031350 1919  35 . . . 520 3889
    UTERU20035770 1920  920 . . . 1282 3890
    UTERU20040150 1921  917 . . . 1717 3891
    UTERU20040370 1922  22 . . . 1866 3892
    UTERU20040390 1923  727 . . . 1200 3893
    UTERU20040730 1924   1009 . . . >2303 3894
    UTERU20041630 1925  105 . . . 1328 3895
    UTERU20041970 1926  26 . . . 484 3896
    UTERU20045200 1927  6 . . . 917 3897
    UTERU20051790 1928  415 . . . 1341 3898
    UTERU20064120 1929  147 . . . 1061 3899
    UTERU20065470 1930 389 . . . 694 3900
    UTERU20079240 1931 408 . . . 713 3901
    UTERU20083020 1932  23 . . . 826 3902
    UTERU20086530 1933 1274 . . . 1783 3903
    UTERU20087070 1934 1274 . . . 2467 3904
    UTERU20087850 1935 464 . . . 991 3905
    UTERU20089300 1936  906 . . . 1253 3906
    UTERU20089390 1937  11 . . . 1729 3907
    UTERU20089620 1938 132 . . . 725 3908
    UTERU20090940 1939 122 . . . 631 3909
    UTERU20091470 1940 260 . . . 697 3910
    UTERU20094830 1941  127 . . . 1578 3911
    UTERU20095100 1942 1593 . . . 1913 3912
    UTERU20099040 1943  59 . . . 883 3913
    UTERU20099510 1944  705 . . . 2375 3914
    UTERU20101150 1945  874 . . . 1188 3915
    UTERU20102260 1946 270 . . . 671 3916
    UTERU20103040 1947 1164 . . . 1772 3917
    UTERU20103200 1948 374 . . . 709 3918
    UTERU20104310 1949  90 . . . 425 3919
    UTERU20106510 1950 1649 . . . 2275 3920
    UTERU20121140 1951  880 . . . 1644 3921
    UTERU20122520 1952    572 . . . >2146 3922
    UTERU20125810 1953  21 . . . 329 3923
    UTERU20127030 1954  618 . . . 1763 3924
    UTERU20127150 1955  707 . . . 1699 3925
    UTERU20128560 1956 203 . . . 721 3926
    UTERU20132620 1957  330 . . . 1007 3927
    UTERU20134830 1958  121 . . . 1341 3928
    UTERU20139760 1959  982 . . . 1659 3929
    UTERU20140010 1960  42 . . . 368 3930
    UTERU20167570 1961  57 . . . 710 3931
    UTERU20168960 1962  317 . . . 1468 3932
    UTERU20169020 1963  30 . . . 782 3933
    UTERU20173030 1964   1985 . . . >2355 3934
    UTERU20176230 1965 1004 . . . 1372 3935
    UTERU20177150 1966  3 . . . 350 3936
    UTERU20181270 1967 153 . . . 620 3937
    UTERU20185220 1968  521 . . . 1357 3938
    UTERU20188670 1969  231 . . . 1886 3939
    UTERU20188840 1970 1834 . . . 2181 3940
  • Namely, primers used to synthesize polynucleotides can be designed based on the nucleotide sequences of polynucleotides of the present invention shown in SEQ ID NOs in the above Table 1. When one intends to synthesize full-length cDNAs, an oligo dT primer can be used as the 3′-end primer. The length of the primers is usually 15-100 bp, and favorably between 15-35 bp. In case of LA PCR, which is described below, the primer length of 25-35 bp may provide a good result.
  • A method to design a primer that enables a specific amplification based on the aimed nucleotide sequence is known to those skilled in the art (Current Protocols in Molecular Biology, Ausubel et al. edit, (1987) John Wiley & Sons, Section 6.1-6.4). In designing a primer based on the 5′-end sequence, the primer is designed so as that, in principle, the amplification products will include the translation start site. Accordingly, for example, when the 5′-end primer is designed based on the nucleotide sequence of 5′ untranslated region (5′UTR), any part of the 5′-end, which ensures the specificity to the cDNA of interest, can be selected as the primer.
  • When synthesizing a full-length cDNA, the target nucleotide sequence to be amplified can extend to several thousand bp in some cDNA. However, it is possible to amplify such a long nucleotides by using such as LA PCR (Long and Accurate PCR). It is advantageous to use LA PCR when synthesizing long DNA. In LA PCR, in which a special DNA polymerase having 3′->5′ exonuclease activity is used, misincorporated nucleotides can be removed. Accordingly, accurate synthesis of the complementary strand can be achieved even with a long nucleotide sequence. By using LA PCR, it is reported that amplification of a nucleotide with 20 kb longer can be achieved under desirable conditions (Takeshi Hayashi (1996) Jikken-Igaku Bessatsu, “Advanced Technologies in PCR” Youdo-sha).
  • A template DNA for synthesizing the full-length cDNA of the present invention can be obtained by using cDNA libraries that are prepared by various methods. The full-length cDNA clones of the present invention are clones with high probability of completeness in length, which were obtained by the method comprising the steps of [1] preparing libraries containing cDNAs with the very high fullness ratio by oligo-capping, and [2] assembling the 5′-end sequences and selecting one with the highest probability of completeness in length in the cluster formed (there are many clones longer in the 5′-end direction).
  • However, the uses of primers designed based on the full-length nucleotide sequences provided by the present invention enable easily obtaining full-length cDNAs without such a special technique.
  • The problem with the cDNA libraries prepared by the known methods or commercially available is that mRNA contained in the libraries has very low fullness ratio. Thus, it is difficult to screen full-length cDNA clone directly from the library using ordinary cloning methods. The present invention has revealed a nucleotide sequence of novel full-length cDNA. If a full-length nucleotide sequence is provided, it is possible to synthesize a target full-length cDNA by using enzymatic reactions such as PCR. In particular, a full-length-enriched cDNA library, synthesized by methods such as oligo-capping, is desirable to synthesize a full-length cDNA with more reliability.
  • The 5′-end sequence of the full-length cDNA clones of the invention can be used to isolate the regulatory element of transcription including the promoter on the genome. A rough draft of the human genome (analysis of human genomic sequence with lower accuracy), which covers 90% of the genome, has been reported (Nature, Vol. 409, 814-823, 2001), and by the year 2003, analysis of the entire human genomic sequence is going to be finished. However, it is hard to analyze with software the transcription start sites on the human genome, in which long introns exist. By contrast, it is easy to specify the transcription start site on the genomic sequence using the nucleotide sequence which includes the 5′-end of the full-length cDNA clone of the present invention, and thus it is easy to obtain the genomic region involved in transcription regulation, which includes the promoter that is contained in the upstream of the transcription start site.
  • The polypeptide encoded by the full-length cDNA of the invention can be prepared as a recombinant polypeptide or as a natural polypeptide. For example, the recombinant polypeptide can be prepared by inserting the polynucleotide encoding the polypeptide of the invention into a vector, introducing the vector into an appropriate host cell and purifying the polypeptide expressed within the transformed host cell, as described below. In contrast, the natural polypeptide can be prepared, for example, by utilizing an affinity column to which an antibody against the polypeptide of the invention (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 16.1-16.19) is attached. The antibody used for affinity purification may be either a polyclonal antibody, or a monoclonal antibody. Alternatively, in vitro translation (See, for example, “On the fidelity of mRNA translation in the nuclease-treated rabbit reticulocyte lysate system.” Dasso M. C., and Jackson R. J. (1989) Nucleic Acids Res. 17: 3129-3144) may be used for preparing the polypeptide of the invention.
  • Polypeptides functionally equivalent to the polypeptides of the present invention can be prepared based on the activities, which were clarified in the above-mentioned manner, of the polypeptides of the present invention. Using the biological activity possessed by the polypeptide of the invention as an index, it is possible to verify whether or not a particular polypeptide is functionally equivalent to the polypeptide of the invention by examining whether or not the polypeptide has said activity.
  • Polypeptides functionally equivalent to the polypeptides of the present invention can be prepared by those skilled in the art, for example, by using a method for introducing mutations into an amino acid sequence of a polypeptide (for example, site-directed mutagenesis (Current Protocols in Molecular Biology, edit, Ausubel et al., (1987) John Wiley & Sons, Section 8.1-8.5) Besides, such polypeptides can be generated by spontaneous mutations. The present invention also includes a polypeptide comprising the amino acid sequence shown in Table 1 in which one or more amino acids are substituted, deleted, inserted, and/or added, as long as the polypeptides have the equivalent functions to those of the polypeptides identified in the present Examples described later.
  • There are no limitations on the number and sites of amino acid mutations, as long as the polypeptides maintain the functions thereof. The number of mutations typically corresponds to 30% or less, or 20% or less, or 10% or less, preferably 5% or less, or 3% or less of the total amino acids, more preferably 2% or less or 1% or less of the total amino acids. Alternatively, herein, substitution of one or more amino acids includes substitution of several amino acids. As used herein, the term “several amino acids” means, for example, 5 amino acids, preferably 4 or 3 amino acids, more preferably 2 amino acids, and further preferably 1 amino acid.
  • From the viewpoint of maintaining the polypeptide function, it is preferable that a substituted amino acid has a similar property to that of the original amino acid. For example, Ala, Val, Leu, Ile, Pro, Met, Phe and Trp are assumed to have similar properties to one another because they are all classified into a group of non-polar amino acids. Similarly, substitution can be performed among non-charged amino acid such as Gly, Ser, Thr, Cys, Tyr, Asn, and Gln, acidic amino acids such as Asp and Glu, and basic amino acids such as Lys, Arg, and His.
  • In addition, polypeptides functionally equivalent to the polypeptides of the present invention can be isolated by using techniques of hybridization or gene amplification known to those skilled in the art. Specifically, using the hybridization technique (Current Protocols in Molecular Biology, edit, Ausubel et al., (1987) John Wiley & Sons, Section 6.3-6.4)), those skilled in the art can usually isolate a polynucleotide highly homologous to the polynucleotide encoding the polypeptide identified in the present Example based on the identified nucleotide sequence (Table 1) or a portion thereof and obtain the functionally equivalent polypeptide from the isolated polynucleotide. The present invention include polypeptides encoded by the polynucleotides hybridizing with the polynucleotides encoding the polypeptides identified in the present Example, as long as the polypeptides are functionally equivalent to the polypeptides identified in the present Example. Organisms from which the functionally equivalent polypeptides are isolated are illustrated by vertebrates such as human, mouse, rat, rabbit, pig and bovine, but are not limited to these animals.
  • Washing conditions of hybridization for the isolation of polynucleotides encoding the functionally equivalent polypeptides are usually “1×SSC, 0.1% SDS, 37° C.”; more stringent conditions are “0.5×SSC, 0.1% SDS, 42° C.”; and still more stringent conditions are “0.1×SSC, 0.1% SDS, 65° C.”. Alternatively, the following conditions can be given as hybridization conditions of the present invention. Namely, conditions in which the hybridization is done at “6×SSC, 40% Formamide, 25° C.”, and the washing at “1×SSC, 55° C.” can be given. More preferable conditions are those in which the hybridization is done at “6×SSC, 40% Formamide, 37° C.”, and the washing at “0.2×SSC, 55° C.”. Even more preferable are those in which the hybridization is done at “6×SSC, 50% Formamide, 37° C.”, and the washing at “0.1×SSC, 62° C.”. The more stringent the conditions of hybridization are, the more frequently the polynucleotides highly homologous to the probe sequence are isolated. Therefore, it is preferable to conduct hybridization under stringent conditions. Examples of stringent conditions in the present invention are, washing conditions of “0.5×SSC, 0.1% SDS, 42° C.”, or alternatively, hybridization conditions of “6×SSC, 40% Formamide, 37° C.”, and the washing at “0.2×SSC, 55° C.”.
  • One skilled in the art can suitably select various conditions, such as dilution ratios of SSC, formamide concentrations, and temperatures to accomplish a similar stringency.
  • However, the above-mentioned combinations of SSC, SDS and temperature conditions are indicated just as examples. Those skilled in the art can select the hybridization conditions with similar stringency to those mentioned above by properly combining the above-mentioned or other factors (for example, probe concentration, probe length and duration of hybridization reaction) that determines the stringency of hybridization.
  • The amino acid sequences of polypeptides isolated by using the hybridization techniques usually have high identity to those of the polypeptides of the present invention, which are shown in Table 1. The present invention encompasses a polynucleotide comprising a nucleotide sequence that has a high identity to the nucleotide sequence of claim 1 (a). Furthermore, the present invention encompasses a peptide, or polypeptide comprising an amino acid sequence that has a high identity to the amino acid sequence encoded by the polynucleotide of claim 1 (b). The term “high identity” indicates sequence identity of at least 40% or more; preferably 60% or more; and more preferably 70% or more. Alternatively, more preferable is identity of 90% or more, or 93% or more, or 95% or more, furthermore, 97% or more, or 99% or more. The identity can be determined by using the BLAST search algorithm.
  • As used herein, “percent identity” of amino acid sequences or nucleic acids is determined using the algorithm BLAST of Karlin and Altschul (Proc. Natl. Acad. Sci. USA 90:5873-5877, 1993). Such an algorithm is incorporated into the BLASTN and BLASTX programs of Altschul et al. (J. Mol. Biol. 215:403-410, 1990). BLAST nucleotide searches are performed with the BLASTN program, for example, score=100, wordlength=12. BLAST protein searches are performed with the BLASTX program, for example, score=50, wordlength=3. When utilizing BLAST and Gapped BLAST programs, the default parameters of the respective programs are used. See http://www.ncbi.nlm.nih.gov.
  • With the gene amplification technique (PCR) (Current Protocols in Molecular Biology, edit, Ausubel et al., (1987) John Wiley & Sons, Section 6.1-6.4)) using primers designed based on the nucleotide sequence (Table 1) or a portion thereof identified in the present Example, it is possible to isolate a polynucleotide fragment highly homologous to the polynucleotide sequence or a portion thereof and to obtain functionally equivalent polypeptide to a particular polypeptide identified in the present Example based on the isolated polynucleotide fragment.
  • The present invention also provides a polynucleotide containing at least 15 nucleotides complementary to a polynucleotide comprising a nucleotide sequence of SEQ ID NOs shown in Table 1 or the complementary strand thereof. Herein, the term “complementary strand” is defined as one strand of a double strand DNA composed of A:T and G:C base pair to the other strand. Also, “complementary” is defined as not only those completely matching within a continuous region of at least 15 nucleotides, but also having a identity of at least 70%, favorably 80% or higher, more favorably 90% or higher, and most favorably 95% or higher within that region. The identity may be determined using the algorithm described herein.
  • Such a polynucleotide includes probes and primers used for the detection and amplification of a polynucleotide encoding the inventive polypeptide. When used as a primer, the polynucleotide usually comprises 15 to 100 bp, and preferably of 15 to 35 bp. When used as a probe, the polynucleotide comprises the whole or a part of the sequence of a polynucleotide of the invention, and comprises at least 15 bp. When used as primers, such polynucleotides are complementary at the 3′-end, and restriction enzyme recognition sequences or tags can be added to the 5′-end.
  • Furthermore, polynucleotides of the present invention include an antisense polynucleotide for suppressing the expression of a polypeptide of the invention, which comprises an amino acid sequence of SEQ ID NOs shown in Table 1. To exert an antisense effect, an antisense polynucleotide has at least 15 bp or more, for example 50 bp or more, preferably 100 bp or more, and more preferably 500 bp or more, and usually has 3000 bp or less, and preferably 2000 bp or less. Antisense polynucleotides can be used in the gene therapy of diseases caused by abnormalities of the polypeptides of the invention (abnormal function or abnormal expression). An antisense polynucleotide can be prepared, for example, by the phosphorothioate method (“Physicochemical properties of phosphorothioate oligodeoxynucleotides.” Stein (1988) Nucleic Acids Res. 16: 3209-3221) based on the sequence information of polynucleotide encoding a polypeptide of the invention (for example, the nucleotide sequences of SEQ ID NO: 1 to 1970).
  • The polynucleotides or antisense polynucleotides of the present invention can be used in, for example, gene therapy. As target diseases, for example, cancers or various inflammatory diseases may be preferable. These molecules can be used for gene therapy, for example, by administrating them to patients by the in vivo or ex vivo method using virus vectors such as retrovirus vectors, adenovirus vectors, and adeno-related virus vectors, or non-virus vectors such as liposomes.
  • The present invention also includes a partial peptide of the polypeptides of the invention. The partial peptide comprises a polypeptide generated as a result that a signal peptide has been removed from a secretory protein. If the polypeptide of the present invention has an activity as a receptor or a ligand, the partial peptide may function as a competitive inhibitor of the polypeptide and may bind to the receptor (or ligand). In addition, the present invention includes an antigen peptide for raising antibodies. For the peptides to be specific for the polypeptide of the invention, the peptides comprise at least 7 amino acids, preferably 8 amino acids or more, more preferably 9 amino acids or more, and even more preferably 10 amino acids or more. The peptide can be used for preparing antibodies against the polypeptide of the invention, or competitive inhibitors of them, and also screening for a receptor that binds to the polypeptide of the invention. The partial peptides of the invention can be produced, for example, by genetic engineering methods, known methods for synthesizing peptides, or digesting the polypeptide of the invention with an appropriate peptidase.
  • The present invention also relates to a vector into which a polynucleotide of the invention is inserted. The vector of the invention is not limited as long as it contains the inserted polynucleotide stably. For example, if E. coli is used as a host, vectors such as pBluescript vector (Stratagene) are preferable as a cloning vector. To produce the polypeptide of the invention, expression vectors are especially useful. Any expression vector can be used as long as it is capable of expressing the polypeptide in vitro, in E. coli, in cultured cells, or in vivo. For example, pBEST vector (Promega) is preferable for in vitro expression, pET vector (Invitrogen) for E. coli, pME18S-FL3 vector (GenBank Accession No. AB009864) for cultured cells, and pME18S vector (Mol. Cell. Biol. (1988) 8: 466-472) for in vivo expression. To insert the polynucleotide of the invention, ligation utilizing restriction sites can be performed according to the standard method (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.4-11.11).
  • Recently, the technique of GATEWAY™ system (Invitrogen), which is an expression vector construction system for polypeptide expression, has been developed (Experimental Medicine, Vol. 18, No. 19 (December), p2716-2717, 2000). This system includes two types of site-specific recombinases (BP CLONASE™ and LR CLONASE™) derived from lambda phage and uses BP CLONASE™-specific recombination sites for an Entry Vector and LR CLONASE™-specific recombination sites for a Destination Vector, which may comprise a tag useful for polypeptide purification. With this system, an expression vector can be obtained by using homologous recombination.
  • First, a polynucleotide fragment of interest is inserted into the entry vector using the first recombination. Then, the secondary recombination is allowed to take place between the entry vector, where the polynucleotide fragment of interest has been inserted, and the destination vector. Thus, the expression vector can be prepared rapidly and highly efficiently. With the above-mentioned typical method using restriction enzyme and ligase reactions, the step of expression vector construction and expression of polypeptide of interest takes about 7 to 10 days. However, with the GATEWAY™ system, the polypeptide of interest can be expressed and prepared in only 3 to 4 days. Thus, the system ensures a high-throughput functional analysis for expressed polypeptides (http://biotech.nikkeibp.co.jp/netlink/lto/gateway/).
  • The present invention also relates to a transformant carrying the vector of the invention. Any cell can be used as a host into which the vector of the invention is inserted, and various kinds of host cells can be used depending on the purposes. For strong expression of the polypeptide in eukaryotic cells, COS cells or CHO cells can be used, for example.
  • Introduction of the vector into host cells can be performed, for example, by calcium phosphate precipitation method, electroporation method (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 9.1-9.9), lipofectamine method (GIBCO-BRL), or microinjection method, etc.
  • Further, a polynucleotide containing at least 15 nucleotides comprising a nucleotide sequence of any one of the polynucleotides comprising the nucleotide sequences of SEQ ID NOs shown in Table 1 or the complementary strand thereof can be used not only as a primer for synthesizing full-length cDNAs but also for testing and diagnosing the abnormalities of the polypeptide encoded by the full-length cDNA of the present invention. For example, by utilizing polymerase chain reaction (genomic DNA-PCR, or RT-PCR) using the polynucleotide of the invention as a primer, polynucleotide encoding the polypeptide of the invention can be amplified. It is also possible to obtain the regulatory region of expression in the 5′-upstream by using PCR or hybridization since the transcription start site within the genomic sequence can be easily specified based on the 5′-end sequence of the full-length cDNA. The obtained genomic region can be used for detection and/or diagnosis of the abnormality of the sequence by RFLP analysis, SSCP, or sequencing. Especially, in the case where expression of the mRNA of the present invention varies according to a specific disease, analysis of the amount of expression of the mRNA using the polynucleotide of the present invention as a probe or a primer enables detection and diagnosis of the disease.
  • The present invention also relates to antibodies that bind to the polypeptide of the invention. There are no limitations in the form of the antibodies of the invention. They include polyclonal antibodies, monoclonal antibodies, or their portions that can bind to an antigen. They also include antibodies of all classes. Furthermore, special antibodies such as humanized antibodies and chimeric antibodies are also included.
  • The polyclonal antibody of the invention can be obtained according to the standard method by synthesizing an oligopeptide corresponding to the amino acid sequence and immunizing rabbits with the peptide (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.12-11.13). The monoclonal antibody of the invention can be obtained according to the standard method by purifying the polypeptide expressed in E. coli, immunizing mice with the polypeptide, and producing a hybridoma cell by fusing the spleen cells and myeloma cells (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.4-11.11).
  • The antibody binding to the polypeptide of the present invention can be used for purification of the polypeptide of the invention, and also for detection and/or diagnosis of the abnormalities of the expression and structure of the polypeptide. Specifically, polypeptides can be extracted, for example, from tissues, blood, or cells, and the polypeptide of the invention is detected by Western blotting, immunoprecipitation, or ELISA, etc. for the above purpose.
  • Furthermore, the antibody binding to the polypeptide of the present invention can be utilized for treating the diseases that associates with the polypeptide of the invention. If the antibodies are used for treating patients, human antibodies, humanized antibodies, or chimeric antibodies are preferable in terms of their low antigenicity. The human antibodies can be prepared by immunizing a mouse whose immune system is replaced with that of human (e.g., see “Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice” Mendez, M. J. et al. (1997) Nat. Genet. 15: 146-156). The humanized antibodies can be prepared by recombination of the hypervariable region of a monoclonal antibody (Methods in Enzymology (1991) 203: 99-121).
  • A cDNA of the present invention encodes, for example, an amino acid sequence of a protein that is predicted to have the following function. The use of the amino acid sequences of the polypeptides encoded by the cDNAs of the present invention enables predicting that the polypeptides have the following functions. It can be predict, from the results of homology search of SwissProt, GenBank, UniGene, or nr, that these polypeptides have such functions. Specifically, for instance, as shown in Examples, searching for a known gene or polypeptide that is homologous to the partial sequence of the full-length cDNA of the invention (1970 clone) and referring the function of the gene and of the polypeptide encoded by the gene make it possible to predict the function of the polypeptide encoded by the cDNA of the invention. In this way, each of 1078 clones out of the 1970 full-length cDNA clones of the invention was predicted to encode a polypeptide that was classified into the following categories.
      • Secretory and/or membrane protein (516 clones)
      • Glycoprotein-related protein (121 clones)
      • Signal transduction-related protein (88 clones)
      • Transcription-related protein (143 clones)
      • Disease-related protein (331 clones)
      • Enzyme and/or metabolism-related protein (219 clones)
      • Cell division- and/or cell proliferation-related protein (44 clones)
      • Cytoskeleton-related protein (80 clones)
      • Nuclear protein and/or RNA synthesis-related protein (70 clones)
      • Protein synthesis- and/or transport-related protein (20 clones)
      • Cellular defense-related protein (10 clones)
      • Development and/or differentiation-related protein (19 clones)
      • DNA- and/or RNA-binding protein (168 clones)
      • ATP- and/or GTP-binding protein (93 clones)
  • The functions of the polypeptides encoded by the cDNAs of the present invention can be predicted by assessing the presence of signal sequence, transmembrane region, nuclear translocation signal, glycosylation signal, phosphorylation site, and zinc finger motif, SH3 domain, etc. in the amino acid sequences. The programs, PSORT (Nakai K., and Kanehisa M. (1992) Genomics 14: 897-911), SOSUI (Hirokawa T. et al. (1998) Bioinformatics 14: 378-379) (Mitsui Knowledge Industry), and MEMSAT (Jones D. T., Taylor W. R., and Thornton J. M. (1994) Biochemistry 33: 3038-3049) can be used to predict the existence of the signal sequence or transmembrane region. Alternatively, a partial amino acid sequence of the polypeptide is fused with another polypeptide such as GFP, the fusion polypeptide is transfected into cultured cells, and the localization is analyzed to predict the function of the original polypeptide.
  • Based on the determined nucleotide sequences of the full-length cDNAs obtained in the present invention, it is possible to predict more detailed functions of the polypeptides encoded by the cDNA clones, for example, by searching the databases such as GenBank, Swiss-Prot, UniGene, and nr for homologies of the cDNAs; or by searching the amino acid sequences deduced from the full-length cDNAs for signal sequences by using software programs such as PSORT, for transmembrane regions by using software programs such as SOSUI or for motifs by using software programs such as Pfam (http://www.sanger.ac.uk/Software/Pfam/index.shtml) and PROSITE (http://www.expasy.ch/prosite/). As a matter of course, the functions are often predictable by using partial sequence information (preferably 300 nucleotides or more) instead of the full-length nucleotide sequences. However, the result of the prediction by using partial nucleotide sequence does not always agree with the result obtained by using full-length nucleotide sequence, and thus, it is needless to say that the prediction of function is preferably performed based on the full-length nucleotide sequences.
  • GenBank, Swiss-Prot, UniGene and nr databases were searched for homologies of the full-length nucleotide sequences of the 1970 clones (see Example 6). The amino acid sequences deduced from the full-length nucleotide sequences were searched for functional domains by PSORT, SOSUI and Pfam. Prediction of functions of polypeptides encoded by the clones and the categorization thereof were performed based on these results obtained. The categorization was carried out by the following method.
  • [1] Firstly, the cDNA clones were classified into the above-mentioned 14 functional categories based on the results of annotation-based categorization (using the keywords in the case of Swiss-Prot hit data; using Definition or Reference information in the case of GenBank, UniGene, or nr hit data), and the signal sequence search of the deduced ORFs by PSORT and the transmembrane region search by SOSUI.
  • [2] Secondly, clones which had been unassignable to the categories by the method of [1] were searched for functional domains and/or motifs by Pfam. Based on the results, the clones were additionally classified into the above-mentioned 14 types of categories when they had a functional domain and/or motif assignable to any one of the categories.
  • The following 516 clones presumably belong to secretory and/or membrane proteins.
    ADRGL20020290, ADRGL20021910, ADRGL20036380, ADRGL20036840, ADRGL20059610,
    ADRGL20063770, ADRGL20066770, ASTRO20010010, ASTRO20020240, ASTRO20045840,
    ASTRO20053430, ASTRO20055530, ASTRO20055570, ASTRO20055930, ASTRO20088950,
    ASTRO20091180, BNGH420021680, BNGH420023870, BNGH420046790, BNGH420052350,
    BNGH420059680, BNGH420075940, BNGH420077980, BRACE10000510, BRACE20051930,
    BRACE20052530, BRACE20054080, BRACE20066360, BRACE20068710, BRACE20069000,
    BRACE20069110, BRACE20194670, BRACE20204670, BRACE20216950, BRAMY10001730,
    BRAMY20003880, BRAMY20013670, BRAMY20024790, BRAMY20027390, BRAMY20028530,
    BRAMY20035380, BRAMY20044920, BRAMY20045210, BRAMY20047560, BRAMY20050940,
    BRAMY20053910, BRAMY20055760, BRAMY20072440, BRAMY20083820, BRAMY20089770,
    BRAMY20091230, BRAMY20094890, BRAMY20096930, BRAMY20118410, BRAMY20123400,
    BRAMY20125550, BRAMY20127310, BRAMY20127760, BRAMY20135720, BRAMY20137360,
    BRAMY20139440, BRAMY20152510, BRAMY20194680, BRAMY20204270, BRAMY20225320,
    BRAMY20237190, BRAMY20245140, BRAMY20251750, BRAMY20285650, BRAWH20020470,
    BRAWH20021910, BRAWH20026010, BRAWH20030000, BRAWH20039640, BRAWH20055330,
    BRAWH20078620, BRAWH20093070, BRAWH20185270, BRCAN10000760, BRCAN10001680,
    BRCAN20001480, BRCAN20004180, BRCAN20005230, BRCOC20000470, BRCOC20003600,
    BRHIP10000720, BRHIP10001040, BRHIP20000210, BRSSN20001970, BRSSN20074640,
    BRSSN20091190, CD34C20001750, CTONG20017490, CTONG20036990, CTONG20041260,
    CTONG20044870, CTONG20045500, CTONG20049480, CTONG20051450, CTONG20055850,
    CTONG20056150, CTONG20059130, CTONG20060040, CTONG20063770,
    CTONG20065680, CTONG20068360, CTONG20069320, CTONG20071680,
    CTONG20076810, CTONG20078340, CTONG20079590, CTONG20083980,
    CTONG20084020, CTONG20085210, CTONG20167750, CTONG20168240,
    CTONG20179890, CTONG20183830, CTONG20184830, DFNES20018000,
    DFNES20029660, DFNES20057660, DFNES20072990, DFNES20080880,
    FCBBF20018680, FCBBF20029280, FCBBF20032930, FCBBF20036360,
    FCBBF20054390, FCBBF30004340, FCBBF30022680, FCBBF30029250,
    FCBBF30042610, FCBBF30062490, FCBBF30075970, FCBBF30078600,
    FCBBF30091520, FCBBF30095410, FCBBF30105440, FCBBF30118670,
    FCBBF30132660, FCBBF30135890, FCBBF30145670, FCBBF30164510,
    FCBBF30169870, FCBBF30171230, FCBBF30172330, FCBBF30177290,
    FCBBF30179740, FCBBF30195690, FCBBF30197840, FCBBF30212210,
    FCBBF30223110, FCBBF30223210, FCBBF30225930, FCBBF30230610,
    FCBBF30260480, FCBBF30266510, FCBBF30287940, FCBBF50000610,
    FCBBF50004950, FEBRA20007820, FEBRA20018670, FEBRA20031280,
    FEBRA20031810, FEBRA20038220, FEBRA20039260, FEBRA20040230,
    FEBRA20040560, FEBRA20046280, FEBRA20080860, FEBRA20084750,
    FEBRA20088810, FEBRA20115930, FEBRA20116650, FEBRA20121950,
    FEBRA20141980, FEBRA20177800, FEBRA20182030, FEBRA20191720,
    HCHON10001660, HCHON20015050, HEART10001490, HEART20031680,
    HHDPC10001140, HHDPC20051850, HHDPC20082790, HHDPC20088160,
    HLUNG20015070, HLUNG20015180, HLUNG20020850, HLUNG20029490,
    HLUNG20032460, HLUNG20033350, HLUNG20034970, HLUNG20037160,
    HLUNG20041540, HLUNG20042730, HLUNG20050760, HLUNG20052300,
    HLUNG20060670, HLUNG20065990, HLUNG20074330, HLUNG20081390,
    HLUNG20088750, HLUNG20092530, KIDNE20016360, KIDNE20083150,
    KIDNE20084030, KIDNE20084040, KIDNE20084800, KIDNE20086490,
    KIDNE20086660, KIDNE20094670, KIDNE20134130, KIDNE20142900,
    KIDNE20143200, KIDNE20148080, KIDNE20160960, KIDNE20163710,
    KIDNE20169180, KIDNE20182540, KIDNE20186170, KIDNE20188630,
    KIDNE20189960, LIVER20007750, LIVER20010510, LIVER20010990,
    LIVER20026440, LIVER20030650, LIVER20038000, MESAN20007110,
    MESAN20008150, MESAN20021220, MESAN20027900, MESAN20058110,
    MESAN20059570, MESAN20060430, MESAN20067430, MESAN20084150,
    MESAN20095220, NT2NE20018740, NT2NE20021860, NT2NE20039210,
    NT2NE20053230, NT2NE20059210, NT2NE20064780, NT2NE20069580,
    NT2NE20080770, NT2NE20082130, NT2NE20092950, NT2NE20140130,
    NT2NE20145250, NT2NE20146510, NT2NE20152620, NT2NE20167660,
    NT2NE20181800, NT2RI20016240, NT2RI20021200, NT2RI20033920,
    NT2RP70003110, NT2RP70027790, NT2RP70031070, NT2RP70031480,
    NT2RP70056690, NT2RP70087140, NTONG20034540, NTONG20053630,
    OCBBF20000740, OCBBF20012520, OCBBF20109780, OCBBF20110210,
    OCBBF20110730, OCBBF20112280, OCBBF20118720, OCBBF20120010,
    OCBBF20123200, OCBBF20155030, OCBBF20165900, OCBBF20165910,
    OCBBF20170350, OCBBF20176650, OCBBF20185630, OCBBF20191950,
    PANCR10000860, PEBLM20001800, PLACE50001290, PLACE60004260,
    PLACE60006300, PLACE60053280, PLACE60055590, PLACE60056910,
    PLACE60057860, PLACE60061370, PLACE60064740, PLACE60070500,
    PLACE60087680, PLACE60104630, PLACE60107010, PLACE60113340,
    PLACE60138840, PLACE60154450, PLACE60184870, PROST10001100,
    PROST20011160, PROST20014150, PROST20035830, PROST20045700,
    PROST20050390, PROST20065100, PROST20073280, PROST20082430,
    PROST20084680, PROST20084720, PROST20099090, PROST20105450,
    PROST20106060, PROST20108850, PROST20110120, PROST20114100,
    PROST20146590, PROST20152510, PROST20168600, PUAEN10000870,
    SKMUS20006790, SKMUS20020770, SKMUS20073150, SKMUS20091900,
    SKNMC20006350, SKNSH20094350, SMINT20006090, SMINT20008110,
    SMINT20024140, SMINT20028840, SMINT20045470, SMINT20077960,
    SMINT20081330, SMINT20086250, SMINT20088440, SMINT20088690,
    SMINT20092160, SPLEN20015100, SPLEN20017610, SPLEN20017810,
    SPLEN20024190, SPLEN20024620, SPLEN20054500, SPLEN20058180,
    SPLEN20063890, SPLEN20073880, SPLEN20080070, SPLEN20090880,
    SPLEN20101950, SPLEN20104690, SPLEN20105100, SPLEN20108000,
    SPLEN20110180, SPLEN20110860, SPLEN20118050, SPLEN20121790,
    SPLEN20125230, SPLEN20136700, SPLEN20138600, SPLEN20139100,
    SPLEN20175920, SPLEN20177400, SPLEN20182850, SPLEN20183020,
    SPLEN20183950, SPLEN20190080, SPLEN20190770, SPLEN20193230,
    SPLEN20193490, SPLEN20193790, SPLEN20201830, SPLEN20204670,
    TESOP10000350, TESTI10000190, TESTI20006160, TESTI20029100,
    TESTI20031310, TESTI20032770, TESTI20038240, TESTI20043130,
    TESTI20043220, TESTI20045390, TESTI20046540, TESTI20046870,
    TESTI20047370, TESTI20050400, TESTI20051200, TESTI20051730,
    TESTI20053260, TESTI20053780, TESTI20057200, TESTI20057590,
    TESTI20059080, TESTI20061200, TESTI20062120, TESTI20063330,
    TESTI20063410, TESTI20063600, TESTI20066330, TESTI20068530,
    TESTI20070400, TESTI20070740, TESTI20073460, TESTI20086840,
    TESTI20095200, TESTI20095440, TESTI20095880, TESTI20100090,
    TESTI20102390, TESTI20105910, TESTI20113940, TESTI20116120,
    TESTI20121040, TESTI20121710, TESTI20131440, TESTI20142540,
    TESTI20149880, TESTI20151800, TESTI20162780, TESTI20170170,
    TESTI20173050, TESTI20182760, TESTI20183680, TESTI20184750,
    TESTI20186110, TESTI20198540, TESTI20199110, TESTI20202830,
    TESTI20204260, TESTI20210030, TESTI20214630, TESTI20219110,
    TESTI20244730, TESTI20245600, TESTI20245860, TESTI20246410,
    TESTI20251610, TESTI20257910, TESTI20260640, TESTI20261040,
    TESTI20262150, TESTI20262940, TESTI20264910, TESTI20271790,
    TESTI20278280, TESTI20282420, TESTI20282900, TESTI20286590,
    THYMU20007020, THYMU20012020, THYMU20017270, THYMU20020800,
    THYMU20025480, THYMU20028150, THYMU20030690, THYMU20034790,
    THYMU20046350, THYMU20046770, THYMU20050010, THYMU20052830,
    THYMU20054800, THYMU20055740, THYMU20055760, THYMU20062770,
    THYMU20078240, THYMU20079690, THYMU20083390, THYMU20087270,
    THYMU20100940, THYMU20115380, THYMU20137050, THYMU20137570,
    THYMU20143230, THYMU20150190, THYMU20153210, THYMU20154790,
    THYMU20163600, THYMU20171580, THYMU20178440, THYMU20185470,
    TRACH20011010, TRACH20011540, TRACH20021380, TRACH20073990,
    TRACH20081270, TRACH20090060, TRACH20149720, TRACH20149740,
    TRACH20159390, TRACH20163470, TRACH20165330, TRACH20167090,
    TRACH20173680, TRACH20190460, UMVEN10001380, UTERU20035770,
    UTERU20040150, UTERU20045200, UTERU20064120, UTERU20086530,
    UTERU20087070, UTERU20087850, UTERU20089300, UTERU20089620,
    UTERU20095100, UTERU20099040, UTERU20103200, UTERU20125810,
    UTERU20127030, UTERU20127150, UTERU20139760, UTERU20188840
  • The following 121 clones presumably belong to glycoprotein-related proteins.
    ADRGL20020290, ADRGL20036840, ADRGL20059610, ADRGL20066770, ASTRO20055570,
    BNGH420046790, BNGH420077980, BRACE20051930, BRACE20069000, BRACE20204670,
    BRACE20216950, BRAMY20013670, BRAMY20089770, BRAMY20251210, BRAWH20039640,
    BRCAN10000760, BRCAN20005230, BRCOC20003600, CD34C20001750, CTONG20017490,
    CTONG20036990, CTONG20045500, CTONG20059130, CTONG20079590, CTONG20085210,
    CTONG20184830, DFNES20018000, DFNES20080880, FCBBF30004340, FCBBF30029250,
    FCBBF30062490, FCBBF30091520, FCBBF30164510, FCBBF30171230, FCBBF30195690,
    FCBBF30223210, FEBRA20038220, HCHON20015050, HLUNG20015070, HLUNG20032460,
    HLUNG20037160, HLUNG20041540, KIDNE20142900, KIDNE20169180, KIDNE20186170,
    KIDNE20189960, MESAN20021220, MESAN20058110, NT2NE20064780, NT2NE20140130,
    NT2NE20155650, NT2RP70056690, NTONG20053630, OCBBF20000740, OCBBF20012520,
    OCBBF20110210, OCBBF20120010, OCBBF20165900, OCBBF20165910, OCBBF20191950,
    PEBLM20001800, PLACE60004260, PLACE60087680, PLACE60113340, PLACE60184870,
    PROST20033240, PROST20099090, PROST20108850, PROST20146590, SKMUS20073150,
    SKNMC20006350, SMINT20028840, SMINT20056230, SMINT20083290, SMINT20091190,
    SPLEN20024620, SPLEN20063890, SPLEN20080070, SPLEN20090880, SPLEN20118050,
    SPLEN20139100, SPLEN20183020, SPLEN20201830, TESTI10000190, TESTI20031310,
    TESTI20043990, TESTI20045390, TESTI20051200, TESTI20057590, TESTI20059080,
    TESTI20066330, TESTI20086840, TESTI20100090, TESTI20105910, TESTI20154370,
    TESTI20164210, TESTI20182760, TESTI20184750, TESTI20199110, TESTI20219110,
    TESTI20220230, TESTI20245600, TESTI20251610, TESTI20257910, TESTI20286590,
    THYMU20024500, THYMU20028150, THYMU20052830, THYMU20062770, THYMU20099060,
    THYMU20170080, THYMU20178440, TRACH20011010, TRACH20011540, TRACH20021380,
    TRACH20149740, TRACH20170860, TRACH20190460, UTERU20086530, UTERU20087070,
    UTERU20127030
  • The following 88 clones presumably belong to signal transduction-related proteins.
    ASTRO20050810, ASTRO20052420, ASTRO20085080, ASTRO20090680, BNGH420008150,
    BNGH420015760, BNGH420035290, BNGH420086030, BRAMY20035830, BRAMY20043630,
    BRAMY20118490, BRAMY20206340, BRAMY20244490, BRAMY20251210, BRAMY20263000,
    BRAWH20093040, BRAWH20190550, CTONG20004520, CTONG20029030, CTONG20030280,
    CTONG20063930, CTONG20070720, CTONG20189000, FCBBF30001100, FCBBF30076310,
    FCBBF30100080, FCBBF30143550, FCBBF30153170, FCBBF30175350, FCBBF30250980,
    FEBRA20090160, FEBRA20173330, HCHON20000870, HLUNG20011260, HLUNG20084790,
    KIDNE20089870, KIDNE20160360, LIVER20011640, MESAN20021130, MESAN20027240,
    MESAN20065990, NT2NE20018890, NT2NE20042550, NT2R270075800, NTONG20043080,
    NTONG20048440, PLACE60071800, PROST20033240, PROST20052850, PROST20065790,
    PROST20075280, SKNSH20052400, SKNSH20057920, SMINT20006020, SMINT20035050,
    SPLEN20023540, SPLEN20039180, SPLEN20048800, SPLEN20049840, SPLEN20054160,
    SPLEN20085910, SPLEN20191020, SPLEN20198390, TESTI20046490, TESTI20049060,
    TESTI20053070, TESTI20066650, TESTI20081890, TESTI20095770, TESTI20106820,
    TESTI20112860, TESTI20145780, TESTI20150420, TESTI20168880, TESTI20205250,
    TESTI20228120, TESTI20244220, TESTI20244460, TESTI20251740, TESTI20261160,
    TESTI20264530, THYMU20013250, THYMU20039320, THYMU20106990, THYMU20145990,
    THYMU20170080, THYMU20176010, TRACH20188350
  • The following 143-clones presumably belong to transcription-related proteins.
    ASTRO20038400, ASTRO20075150, BNGH420070370, BNGH420074600, BNGH420087430,
    BRACE20003310, BRACE20061620, BRAMY20001510, BRAMY20040580, BRAMY20076100,
    BRAMY20111780, BRAWH20040680, BRAWH20050740, BRAWH20080580, BRAWH20082920,
    BRAWH20095900, BRSSN20066440, CTONG20020950, CTONG20044230, CTONG20053990,
    CTONG20072930, CTONG20074000, CTONG20084660, CTONG20186370, CTONG20186520,
    DFNES20028170, DFNES20046840, DFNES20073320, FCBBF30003610, FCBBF30019140,
    FCBBF30021900, FCBBF30093170, FCBBF30114850, FCBBF30129010, FCBBF30136230,
    FCBBF30143550, FCBBF30220050, FCBBF30228940, FCBBF30263080, FCBBF30285930,
    FCBBF50003530, FEBRA20026820, FEBRA20027070, FEBRA20046510, FEBRA20057010,
    FEBRA20063720, FEBRA20170240, HCHON10000150, HCHON20002650, HEART20019310,
    HLUNG20014590, HLUNG20028110, HLUNG20063700, KIDNE20140870, LIVER20006260,
    MESAN20016270, MESAN20038520, NT2NE20038870, NT2NE20053950, NT2NE20060750,
    NT2NE20061030, NT2NE20079670, NT2NE20082600, NT2RP70001120, NT2RP70029780,
    NT2RP70046410, NT2RP70057500, NT2RP70075300, NT2RP70090870, OCBBF20116250,
    OCBBF20120950, OCBBF20121910, OCBBF20156450, OCBBF20157970, OCBBF20166900,
    OCBBF20175360, OCBBF20177540, PEBLM20003260, PLACE60052940, PLACE60066970,
    PLACE60122970, PLACE60150510, PLACE60177880, PROST20007170, PROST20024250,
    PROST20035170, PROST20127450, PROST20151370, PROST20155370, PUAEN10000650,
    PUAEN20003120, SMINT20011950, SMINT20026200, SMINT20030740, SMINT20039050,
    SMINT20044140, SMINT20086720, SPLEN20042200, SPLEN20043680, SPLEN20055600,
    SPLEN20059270, SPLEN20063250, SPLEN20098030, SPLEN20197930, TESTI10001570,
    TESTI20057430, TESTI20057840, TESTI20059810, TESTI20067480, TESTI20068790,
    TESTI20075240, TESTI20079220, TESTI20088840, TESTI20104090, TESTI20122070,
    TESTI20166670, TESTI20171070, TESTI20173960, TESTI20184760, TESTI20194880,
    TESTI20197600, TESTI20228740, TESTI20254030, TESTI20254990, TESTI20266050,
    TESTI20274960, TESTI20282530, THYMU10004280, THYMU20019260, THYMU20032820,
    THYMU20071120, THYMU20077250, TKIDN10001920, UTERU20016580, UTERU20026620,
    UTERU20041630, UTERU20094830, UTERU20099510, UTERU20101150, UTERU20169020,
    UTERU20177150, UTERU20185220, UTERU20188670
  • The following 331 clones presumably belong to disease-related proteins.
    ADRGL20020290, ADRGL20021910, ADRGL20026790, ADRGL20036840, ADRGL20059610,
    ADRGL20066770, ASTRO20038400, ASTRO20052420, ASTRO20055570, ASTRO20075150,
    ASTRO20088950, BNGH420008150, BNGH420086030, BRACE10000510, BRACE20003310,
    BRACE20069000, BRACE20097540, BRACE20194670, BRACE20196180, BRACE20204670,
    BRACE20216950, BRAMY20003540, BRAMY20005080, BRAMY20035830, BRAMY20040580,
    BRAMY20043630, BRAMY20044920, BRAMY20051820, BRAMY20056620, BRAMY20089770,
    BRAMY20111780, BRAMY20152510, BRAMY20190550, BRAMY20221600, BRAMY20227860,
    BRAMY20274510, BRAWH20082920, BRAWH20093040, BRAWH20095900, BRAWH20190530,
    BRAWH20191980, BRCAN10000760, BRCAN10001050, BRCAN20005230, BRSSN20066440,
    CTONG20004520, CTONG20029030, CTONG20042640, CTONG20045500, CTONG20052780,
    CTONG20053990, CTONG20070780, CTONG20070910, CTONG20072930, CTONG20083980,
    CTONG20084660, CTONG20165750, CTONG20169040, CTONG20183430, CTONG20183830,
    CTONG20186290, CTONG20189000, DFNES20016470, DFNES20025500, DFNES20046840,
    DFNES20055400, DFNES20080880, FCBBF10000230, FCBBF20035490, FCBBF20066340,
    FCBBF30002270, FCBBF30002280, FCBBF30019140, FCBBF30053300, FCBBF30071500,
    FCBBF30072440, FCBBF30076310, FCBBF30080730, FCBBF30100080, FCBBF30115920,
    FCBBF30118670, FCBBF30129010, FCBBF30132050, FCBBF30136230, FCBBF30153170,
    FCBBF30164510, FCBBF30166220, FCBBF30171230, FCBBF30175350, FCBBF30194550,
    FCBBF30220050, FCBBF30223210, FCBBF30259050, FCBBF30263080, FCBBF30275590,
    FCBBF50001650, FEBRA20027070, FEBRA20045380, FEBRA20046200, FEBRA20046510,
    FEBRA20057010, FEBRA20063720, FEBRA20078800, FEBRA20087550,
    FEBRA20088810, FEBRA20090160, FEBRA20092760, FEBRA20151750,
    FEBRA20170240, FEBRA20173330, FEBRA20191720, HCHON10000150,
    HCHON20015050, HEART20009590, HEART20022200, HEART20063100,
    HHDPC20081230, HLUNG20008460, HLUNG20014590, HLUNG20032460,
    HLUNG20063700, HLUNG20065990, HLUNG20069350, HLUNG20081530,
    HLUNG20082350, HLUNG20083330, HLUNG20085210, KIDNE20081170,
    KIDNE20084040, KIDNE20088240, KIDNE20089870, KIDNE20133460,
    KIDNE20134890, KIDNE20141700, KIDNE20142900, KIDNE20150730,
    KIDNE20152440, KIDNE20160360, KIDNE20165390, KIDNE20169180,
    KIDNE20173430, KIDNE20189960, LIVER20026440, MESAN20006200,
    MESAN20021130, MESAN20033220, MESAN20056890, MESAN20057240,
    MESAN20065990, MESAN20067430, MESAN20069530, NESOP20004520,
    NT2NE20018890, NT2NE20026200, NT2NE20037050, NT2NE20053950,
    NT2NE20061030, NT2NE20111190, NT2NE20117580, NT2NE20119980,
    NT2NE20140130, NT2NE20141040, NT2RI20093010, NT2RP70003110,
    NT2RP70046410, NT2RP70075300, NTONG20032100, NTONG20034540,
    OCBBF20000740, OCBBF20012520, OCBBF20111600, OCBBF20120010,
    OCBBF20156450, OCBBF20157970, OCBBF20191950, PEBLM20001800,
    PEBLM20003260, PLACE60004260, PLACE60012620, PLACE60054230,
    PLACE60054870, PLACE60062660, PLACE60087680, PLACE60184870,
    PROST20015210, PROST20024250, PROST20036350, PROST20050390,
    PROST20058860, PROST20063430, PROST20065790, PROST20084720,
    PROST20099090, PROST20120070, PROST20127450, PROST20146590,
    PROST20152510, PROST20168600, PUAEN10000650, PUAEN20003120,
    SKMUS20008730, SKMUS20017400, SKMUS20040440, SKMUS20073590,
    SKMUS20079150, SKNSH20009710, SMINT20002320, SMINT20007470,
    SMINT20008110, SMINT20011950, SMINT20016150, SMINT20026200,
    SMINT20030740, SMINT20049920, SMINT20077960, SMINT20083290,
    SMINT20086250, SMINT20089600, SMINT20091190, SPLEN20023540,
    SPLEN20024190, SPLEN20042200, SPLEN20043680, SPLEN20055600,
    SPLEN20057830, SPLEN20059270, SPLEN20063890, SPLEN20073500,
    SPLEN20080070, SPLEN20085910, SPLEN20090880, SPLEN20098030,
    SPLEN20118050, SPLEN20136730, SPLEN20138600, SPLEN20139100,
    SPLEN20139360, SPLEN20180980, SPLEN20187490, SPLEN20193790,
    SPLEN20201830, TESTI10000190, TESTI20031310, TESTI20035790,
    TESTI20041630, TESTI20049060, TESTI20050720, TESTI20051200,
    TESTI20057430, TESTI20057590, TESTI20059080, TESTI20062120,
    TESTI20067480, TESTI20071630, TESTI20099350, TESTI20105130,
    TESTI20105910, TESTI20108060, TESTI20125920, TESTI20130530,
    TESTI20131440, TESTI20134680, TESTI20142540, TESTI20143180,
    TESTI20150420, TESTI20154370, TESTI20164210, TESTI20166670,
    TESTI20168880, TESTI20171070, TESTI20182760, TESTI20184750,
    TESTI20193080, TESTI20194880, TESTI20196970, TESTI20197600,
    TESTI20201760, TESTI20207170, TESTI20219110, TESTI20228740,
    TESTI20244430, TESTI20246480, TESTI20251740, TESTI20252690,
    TESTI20254030, TESTI20257910, TESTI20258720, TESTI20266050,
    TESTI20271790, TESTI20274960, TESTI20282530, TESTI20286590,
    THYMU10004280, THYMU20006020, THYMU20013250, THYMU20019260,
    THYMU20023560, THYMU20028150, THYMU20032820, THYMU20034400,
    THYMU20055460, THYMU20063650, THYMU20070250, THYMU20071120,
    THYMU20081110, THYMU20090230, THYMU20095920, THYMU20098350,
    THYMU20099060, THYMU20120730, THYMU20121040, THYMU20170080,
    THYMU20185650, THYMU20191970, TKIDN10000620, TKIDN10001920,
    TRACH20011540, TRACH20091070, TRACH20143710, TRACH20170860,
    UTERU10001060, UTERU20026620, UTERU20041630, UTERU20086530,
    UTERU20087070, UTERU20087850, UTERU20099510, UTERU20101150,
    UTERU20104310, UTERU20127030, UTERU20185220
  • The following 219 clones presumably belong to the category of enzymes and/or metabolism-related proteins.
    ADRGL20059610, ASTRO20026320, ASTRO20050810, ASTRO20088950, BNGH420008150,
    BNGH420035290, BNGH420074600, BRACE20050870, BRACE20097540, BRACE20200770,
    BRACE20204670, BRACE20215410, BRAMY20003540, BRAMY20005080, BRAMY20027990,
    BRAMY20028620, BRAMY20044920, BRAMY20055760, BRAMY20056620, BRAMY20072870,
    BRAMY20093490, BRAMY20096930, BRAMY20118490, BRAMY20125360, BRAMY20143870,
    BRAMY20152510, BRAMY20231150, BRAMY20244490, BRAMY20251210, BRAWH20021910,
    BRAWH20082920, BRAWH20093040, BRAWH20094900, BRAWH20183170, BRAWH20188750,
    BRAWH20190550, BRAWH20191980, BRCAN20005230, BRCOC20003600, CTONG20051100,
    CTONG20070910, CTONG20076810, CTONG20079590, CTONG20080140, CTONG20085210,
    CTONG20186290, DFNES20063460, DFNES20080880, FCBBF20023490, FCBBF20066340,
    FCBBF30004340, FCBBF30019140, FCBBF30022680, FCBBF30029250, FCBBF30072440,
    FCBBF30076310, FCBBF30085560, FCBBF30091520, FCBBF30107290, FCBBF30125880,
    FCBBF30132050, FCBBF30143550, FCBBF30153170, FCBBF30166220, FCBBF30171230,
    FCBBF30175350, FCBBF30236670, FCBBF30260480, FEBRA20038220, FEBRA20040560,
    FEBRA20078800, FEBRA20090160, FEBRA20172230, FEBRA20173330, HCHON20000870,
    HCHON20002710, HEART10001490, HEART20022200, HEART20047640, HEART20082570,
    HLUNG20011260, HLUNG20032460, HLUNG20041540, HLUNG20042730, HLUNG20054790,
    KIDNE20080690, KIDNE20083620, KIDNE20084040, KIDNE20147170, KIDNE20152440,
    KIDNE20173150, KIDNE20186170, KIDNE20189960, LIVER20011640, LIVER20026440,
    LIVER20055270, MESAN20021130, MESAN20033220, MESAN20038520, MESAN20057240,
    MESAN20058110, MESAN20065990, MESAN20095800, NT2NE20026200,
    NT2NE20042550, NT2NE20117580, NT2NE20127900, NT2RI20093010,
    NT2RP70064570, NTONG20034540, NTONG20043080, NTONG20053630,
    NTONG20053730, NTONG20058010, OCBBF20120010, OCBBF20167290,
    OCBBF20191950, PANCR10000860, PLACE60052940, PLACE60064180,
    PLACE60073090, PLACE60095600, PLACE60184410, PLACE60188630,
    PROST20007600, PROST20033240, PROST20036350, PROST20039300,
    PROST20050390, PROST20051310, PROST20052850, PROST20065790,
    PROST20075280, PROST20084720, PROST20099090, PROST20108850,
    PROST20152510, PUAEN20001520, PUAEN20002470, SKNMC20006350,
    SKNSH20057920, SMINT20008110, SMINT20049920, SMINT20094680,
    SPLEN20023540, SPLEN20024930, SPLEN20043680, SPLEN20048800,
    SPLEN20054500, SPLEN20057900, SPLEN20071820, SPLEN20080070,
    SPLEN20085910, SPLEN20108000, SPLEN20136730, SPLEN20180980,
    TESTI20012080, TESTI20030200, TESTI20031310, TESTI20038240,
    TESTI20050720, TESTI20051200, TESTI20059080, TESTI20062120,
    TESTI20066330, TESTI20076570, TESTI20103690, TESTI20105130,
    TESTI20106820, TESTI20108060, TESTI20112860, TESTI20121040,
    TESTI20130530, TESTI20131440, TESTI20168880, TESTI20170170,
    TESTI20196690, TESTI20196970, TESTI20199110, TESTI20205250,
    TESTI20212970, TESTI20222030, TESTI20226520, TESTI20227380,
    TESTI20244460, TESTI20244730, TESTI20250630, TESTI20260640,
    TESTI20262940, TESTI20264530, TESTI20285230, THYMU20006020,
    THYMU20013250, THYMU20034400, THYMU20039320, THYMU20055460,
    THYMU20055760, THYMU20063650, THYMU20066660, THYMU20070250,
    THYMU20087270, THYMU20096580, THYMU20100940, THYMU20110720,
    THYMU20120240, THYMU20120730, THYMU20170230, TRACH20011010,
    TRACH20021380, TRACH20091070, TRACH20113020, TRACH20143710,
    TRACH20164100, TRACH20190460, UTERU20087070, UTERU20089620,
    UTERU20104310, UTERU20185220, UTERU20188670
  • The following 44 clones presumably belong to the category of cell division- and/or cell proliferation-related proteins.
    ASTRO20090680, BRACE20079370, BRAMY20234820, BRCAN10001050, BRCAN20005410,
    CTONG20032930, FCBBF20070950, FCBBF30002270, FCBBF30053300, FCBBF30105860,
    FCBBF30175350, FCBBF30215240, FCBBF30275590, FEBRA20045380, HLUNG20068120,
    KIDNE20134890, KIDNE20150730, MESAN20021470, NT2NE20077250, NT2NE20153620,
    NT2RP70030840, NTONG20053910, OCBBF20111370, OCBBF20174580, PROST20063430,
    SKNMC10001230, SMINT20028800, SPLEN20023540, SPLEN20057830, SPLEN20139360,
    TESTI20031410, TESTI20057840, TESTI20065650, TESTI20066650, TESTI20107320,
    TESTI20108060, TESTI20114480, TESTI20134680, TESTI20143180, TESTI20150920,
    TESTI20201760, TESTI20278280, TESTI20284260, THYMU20097920
  • The following 80 clones presumably belong to the category of cytoskeleton-related proteins.
    ADRGL20062330, ASTRO20053430, BGGI120000670, BRACE20079370, BRAMY20038980,
    BRAMY20083330, BRAMY20094890, CTONG20004110, CTONG20032930, CTONG20077760,
    CTONG20083980, CTONG20169040, CTONG20183430, DFNES20018000, FCBBF30105860,
    FCBBF30130410, FCBBF30194550, FCBBF30201630, FCBBF30271990, FEBRA20005040,
    FEBRA20046200, FEBRA20099860, HCHON20015050, HLUNG20081530, KIDNE20081170,
    NT2RP70001730, NT2RP70003110, NTONG20032100, OCBBF20166890, OCBBF20174890,
    PLACE60054870, PLACE60055590, PLACE60071800, PLACE60118810, PROST20015210,
    PROST20097840, PROST20120070, PROST20146590, SKMUS20007260, SKMUS20008730,
    SKMUS20017400, SKMUS20073590, SMINT20062050, SMINT20074330, SMINT20077960,
    SPLEN20039180, SPLEN20049840, SPLEN20076470, SPLEN20182990, SPLEN20187490,
    SPLEN20195710, TESTI10000190, TESTI20041630, TESTI20057880, TESTI20058920,
    TESTI20060080, TESTI20064530, TESTI20064650, TESTI20065650, TESTI20067440,
    TESTI20071130, TESTI20099350, TESTI20112540, TESTI20125280, TESTI20136010,
    TESTI20153310, TESTI20175370, TESTI20222460, TESTI20244430, TESTI20254030,
    TESTI20258720, THYMU20024500,THYMU20062610, THYMU20098350, TRACH20043360,
    TRACH20098510, TRACH20149500, UTERU20089390, UTERU20122520, UTERU20168960
  • The following 70 clones presumably belong to the category of nuclear proteins and/or RNA synthesis-related proteins.
    ASTRO20026320, BRACE20050870, BRACE20200770, BRAMY20134050, BRAWH20063010,
    BRAWH20093040, BRAWH20174330, BRAWH20176850, CTONG20042640, FCBBF20023490,
    FCBBF20035490, FCBBF20070950, FCBBF30002270, FCBBF30048420, FCBBF30080730,
    FCBBF30115920, FCBBF30236670, FEBRA20035240, FEBRA20092760, FEBRA20173330,
    HHDPC20081230, HLUNG20011460, HLUNG20068120, KIDNE20089870, KIDNE20150730,
    MESAN20056890, MESAN20057240, NT2NE20037050, NT2NE20167660, NT2RP70031070,
    NTONG20053730, PLACE60064180, PLACE60095600, PROST20016760, PROST20051310,
    PROST20058860, PROST20152510, PUAEN20002470, SKMUS20079150, SKNSH20030640,
    SPLEN20023850, SPLEN20057830, SPLEN20139360, SPLEN20190430, TESTI20006830,
    TESTI20030200, TESTI20031410, TESTI20035790, TESTI20062120, TESTI20065650,
    TESTI20081890, TESTI20150920, TESTI20153310, TESTI20201760, TESTI20212970,
    TESTI20227380, TESTI20251740, TESTI20256560, TESTI20260640, TESTI20270130,
    TESTI20284260, TESTI20285230, THYMU20021090, THYMU20049060, THYMU20066660,
    THYMU20081110, THYMU20090230, THYMU20120240, UTERU10001060, UTERU20104310
  • The following 20 clones presumably belong to the category of protein synthesis- and/or protein transport-related proteins.
    BRAMY20038980, BRAMY20274510, CTONG20008190,
    CTONG20033610, FCBBF20018680, FEBRA20090220,
    KIDNE20141700, NT2NE20167660, NTONG20055200,
    PLACE60012620, PROST20036350, PROST20062820,
    SKMUS20040440, SMINT20000070, SPLEN20180980,
    TESTI20055680, TESTI20067440, TESTI20107240,
    THYMU20096580, THYMU20121040
  • The following 10 clones presumably belong to the category of cellular defense-related proteins.
    ASTRO20089600, BRAMY20117670,
    FEBRA20087550, HLUNG20081390,
    MESAN20057240, NTONG20031580,
    PROST20007600, SPLEN20023850,
    SPLEN20043680, TESTI20261680
  • The following 19 clones presumably belong to the category of development and/or differentiation-related proteins.
    BRACE20061620, BRACE20200770,
    BRAMY20013670, CTONG20017490,
    CTONG20020950, HCHON10000150,
    MESAN20021470, OCBBF20165910,
    PROST20155370, PUAEN20002470,
    TESTI20079220, TESTI20079980,
    TESTI20166670, TESTI20184760,
    TESTI20252690, TRACH20040390,
    UTERU20089620, UTERU20094830,
    UTERU20169020
  • The following 168 clones presumably belong to the category of DNA- and/or RNA-binding proteins.
    ASTRO20038400, BGGI120010750,
    BNGH420070370, BRACE20003310,
    BRACE20061620, BRAMY20001510,
    BRAMY20040580, BRAMY20076100,
    BRAMY20111780, BRAMY20274510,
    BRAWH20040680, BRAWH20050740,
    BRAWH20063010, BRAWH20080580,
    BRAWH20095900, BRAWH20174330,
    BRSSN20066440, CTONG20020950,
    CTONG20044230, CTONG20053990,
    CTONG20072930, CTONG20074000,
    CTONG20165750, CTONG20186370,
    CTONG20186520, DFNES20046840,
    DFNES20073320, FCBBF20035430,
    FCBBF20070950, FCBBF30002270,
    FCBBF30003610, FCBBF30019140,
    FCBBF30021900, FCBBF30048420,
    FCBBF30080730, FCBBF30093170,
    FCBBF30114850, FCBBF30129010,
    FCBBF30136230, FCBBF30220050,
    FCBBF30228940, FCBBF30236670,
    FCBBF30263080, FCBBF30285930,
    FCBBF50003530, FEBRA20026820,
    FEBRA20027070, FEBRA20035240,
    FEBRA20046510, FEBRA20057010,
    FEBRA20063720, FEBRA20087550,
    FEBRA20092760, FEBRA20170240,
    FEBRA20177800, HCHON20002650,
    HEART20019310, HEART20063100,
    HHDPC20081230, HLUNG20011460,
    HLUNG20014590, HLUNG20028110,
    HLUNG20063700, HLUNG20068120,
    KIDNE20140870, LIVER20006260,
    MESAN20016270, MESAN20056890,
    MESAN20057240, NT2NE20038870,
    NT2NE20053950, NT2NE20060750,
    NT2NE20079670, NT2NE20082600,
    NT2NE20087270, NT2RP70029780,
    NT2RP70046410, NT2RP70057500,
    NT2RP70075300, NT2RP70090870,
    OCBBF20116250, OCBBF20120950,
    OCBBF20121910, OCBBF20156450,
    OCBBF20157970, OCBBF20166900,
    OCBBF20175360, OCBBF20177540,
    PEBLM10001470, PEBLM20003260,
    PLACE60066970, PLACE60122970,
    PLACE60177880, PROST20007170,
    PROST20024250, PROST20035170,
    PROST20051310, PROST20058860,
    PROST20151370, PROST20155370,
    PUAEN20003120, SMINT20011950,
    SMINT20030740, SMINT20039050,
    SMINT20044140, SMINT20086720,
    SPLEN20042200, SPLEN20043680,
    SPLEN20055600, SPLEN20059270,
    SPLEN20063250, SPLEN20139360,
    SPLEN20190430, TESTI10001570,
    TESTI20006830, TESTI20030200,
    TESTI20031410, TESTI20035790,
    TESTI20057430, TESTI20059810,
    TESTI20062120, TESTI20067480,
    TESTI20068790, TESTI20075240,
    TESTI20079220, TESTI20088840,
    TESTI20104090, TESTI20134970,
    TESTI20166670, TESTI20171070,
    TESTI20173960, TESTI20184760,
    TESTI20197600, TESTI20201760,
    TESTI20212970, TESTI20227380,
    TESTI20228740, TESTI20246480,
    TESTI20254030, TESTI20254990,
    TESTI20266050, TESTI20268240,
    TESTI20270130, TESTI20274960,
    TESTI20282530, TESTI20284260,
    TESTI20285230, THYMU10004280,
    THYMU20019260, THYMU20023560,
    THYMU20032820, THYMU20049060,
    THYMU20066660, THYMU20071120,
    THYMU20077250, THYMU20081110,
    THYMU20090230, TKIDN10001920,
    TRACH20108240, UTERU10001060,
    UTERU20026620, UTERU20041630,
    UTERU20094830, UTERU20099510,
    UTERU20101150, UTERU20169020,
    UTERU20177150, UTERU20188670
  • The following 93 clones presumably belong to the category of ATP- and/or GTP-binding proteins.
    ASTRO20026320, BNGH420035290,
    BRACE20050870, BRACE20079370,
    BRACE20200770, BRAMY20055760,
    BRAMY20118490, BRAMY20244490,
    BRAMY20251210, BRAWH20093040,
    BRAWH20190550, BRCAN10001050,
    BRCOC20003600, CTONG20008190,
    CTONG20030280, CTONG20032930,
    CTONG20176040, CTONG20184830,
    FCBBF20023490, FCBBF30019140,
    FCBBF30076310, FCBBF30105860,
    FCBBF30175350, FCBBF30201630,
    FCBBF30236670, FEBRA20005040,
    FEBRA20090160, FEBRA20173330,
    HCHON20000870, HLUNG20011260,
    HLUNG20052300, KIDNE20081170,
    KIDNE20134890, LIVER20030650,
    LIVER20055270, MESAN20065990,
    NT2NE20042550, NTONG20043080,
    NTONG20055200, OCBBF20182060,
    PLACE60054870, PLACE60064180,
    PLACE60095600, PLACE60140640,
    PROST20015210, PROST20033240,
    PROST20036350, PROST20051310,
    PROST20052850, PROST20062820,
    PROST20075280, PROST20120070,
    PUAEN20002470, SKNSH20052400,
    SKNSH20057920, SMINT20008110,
    SPLEN20023850, SPLEN20043680,
    SPLEN20049840, SPLEN20136730,
    SPLEN20180980, SPLEN20193790,
    TESTI20055680, TESTI20058920,
    TESTI20060080, TESTI20064650,
    TESTI20071130, TESTI20099350,
    TESTI20106820, TESTI20112860,
    TESTI20134680, TESTI20136010,
    TESTI20143180, TESTI20175370,
    TESTI20212970, TESTI20222460,
    TESTI20227380, TESTI20244220,
    TESTI20244460, TESTI20264530,
    THYMU20013250, THYMU20039320,
    THYMU20062610, THYMU20066660,
    THYMU20087270, THYMU20096580,
    THYMU20100940, THYMU20176010,
    TRACH20043360, TRACH20098510,
    TRACH20113020, UTERU20185220,
    UTERU20188670
  • Among the clones other than the ones shown above, BNGH420036410, FCBBF30257370 are clones which were predicted to highly possibly belong to the category of secretory protein and/or membrane protein based on the result of domain search by Pfam.
  • SMINT20044730, TESTI20140970
  • The two clones shown above are clones which were predicted to highly possibly belong to the category of glycoprotein-related protein based on the result of domain search by Pfam.
    BRACE20055560, CTONG20046690,
    DFNES20043710, FCBBF30005500,
    MESAN20030350, MESAN20030370,
    PLACE60074820, TESTI20058350,
    TESTI20106170, TRACH20131230,
    UTERU20000950
  • The 11 clones shown above are clones which were predicted to highly possibly belong to the category of signal transduction-related protein based on the result of domain search by Pfam.
    ASTRO20010290, BRACE20099070,
    CTONG20007660, DFNES20076340,
    DFNES20094820, FCBBF30125460,
    FCBBF30142290, FCBBF30169280,
    FEBRA20031000, NT2NE20026510,
    NT2RP70031340, PLACE50001390,
    SPLEN20135030, TESTI20046890,
    TESTI20060350, TESTI20166290,
    TESTI20259110, THYMU20184550
  • The 18 clones shown above are clones which were predicted to highly possibly belong to the category of transcription-related protein based on the result of domain search by Pfam.
    ADRGL20047770, ADRGL20079060,
    BRACE20014450, BRACE20051600,
    BRAWH20185260, CTONG20033750,
    CTONG20070090, CTONG20190290,
    FCBBF20020440, FCBBF30005360,
    FCBBF30173960, FEBRA20031000,
    KIDNE20087880, LIVER20013890,
    MESAN20030350, MESAN20030370,
    OCBBF20113110, PLACE60074820,
    PLACE60093380, PROST20028970,
    PROST20102190, SALGL10001070,
    SPLEN20006950, SPLEN20011350,
    SPLEN20050090, TESTI20060830,
    TESTI20066150, TESTI20120900,
    TESTI20132310, TESTI20148380,
    TESTI20162980, TESTI20166290,
    TESTI20205100, THYMU20112590,
    TRACH20029880
  • The 35 clones shown above are clones which were predicted to highly possibly belong to the category of enzyme and/or metabolism-related protein based on the result of domain search by Pfam.
  • PLACE60054820, TESTI20197030
  • The two clones shown above are clones which were predicted to highly possibly belong to the category of cell division and/or cell proliferation-related protein based on the result of domain search by Pfam.
  • ASTRO20006530, OCBBF20016390, TRACH20058000
  • The three clones shown above are clones which were predicted to highly possibly belong to the category of cytoskeleton-related protein based on the result of domain search by Pfam.
  • BRACE20065470, PLACE60054820
  • The two clones shown above are clones which were predicted to highly possibly belong to the category of nuclear protein and/or RNA synthesis-related protein based on the result of domain search by Pfam.
    ASTRO20010290, BRACE20099070,
    BRAWH20014590, CTONG20007660,
    DFNES20076340, DFNES20094820,
    FCBBF30125460, FCBBF30142290,
    FCBBF30169280, FEBRA20031000,
    MESAN20034440, NT2NE20026510,
    NT2RP70031340, PLACE50001390,
    SPLEN20135030, TESTI20046890,
    TESTI20060350, TESTI20166290,
    TESTI20259110, THYMU20104480,
    THYMU20184550
  • The 21 clones shown above are clones which were predicted to highly possibly belong to the category of DNA- and/or RNA-binding protein based on the result of domain search by Pfam.
  • KIDNE20133880, MESAN20030350, MESAN20030370, TESTI20059480
  • The four clones shown above are clones which were predicted to highly possibly belong to the category of ATP- and/or GTP-binding proteins based on the result of domain search by Pfam.
  • The 205 clones shown below are clones which were unassignable to any of the above-mentioned categories, but have been predicted to have some functions based on homology search using their full-length nucleotide sequences and motif search in their estimated ORFs. Clone Name, Definition in the result of homology search or Motif Name in the motif search, demarcated by a double slash mark (//), are shown below.
    • ADRGL20022600//DIAPHANOUS PROTEIN HOMOLOG 1 (P140MDIA).
    • ADRGL20023920//ABC1 PROTEIN HOMOLOG PRECURSOR.
    • ASTRO20001910//Rattus norvegicus mRNA for annexin V-binding protein (ABP-10), partial cds.
    • ASTRO20009140//PUTATIVE COMPETENCE-DAMAGE PROTEIN.
    • ASTRO20046280//PSU1 PROTEIN.
    • ASTRO20058960//DNA damage inducible protein homolog—fission yeast (Schizosaccharomyces pombe)
    • BNGH420024870//C2 domain//C2 domain//C2 domain
    • BRACE20007330//RING CANAL PROTEIN (KELCH PROTEIN).
    • BRACE20052430//Homo sapiens AMSH mRNA, complete cds.
    • BRACE20054600//Xenopus laevis mRNA for Kielin, complete cds.
    • BRACE20059810//TSC-22/dip/bun family
    • BRACE20063540//MEROZOITE SURFACE PROTEIN CMZ-8 (FRAGMENT).
    • BRACE20079200//Xenopus laevis mRNA for Kielin, complete cds.
    • BRAMY20016780//Proprotein convertase P-domain
    • BRAMY20023640//UBX domain
    • BRAMY20045420//Domain found in Dishevelled, Egl-10, and Pleckstrin
    • BRAMY20056840//UBE-1c2
    • BRAMY20063750//Homo sapiens HRIHFB2007 mRNA, partial cds.
    • BRAMY20102900//Homo sapiens RU1 (RU1) mRNA, complete cds.
    • BRAMY20158550//CALMODULIN.
    • BRAMY20223010//Mus musculus leucine-rich glioma-inactivated 1 protein precursor, (Lgi1) mRNA, complete cds.
    • BRAMY20238630//TETRATRICOPEPTIDE REPEAT PROTEIN 4.
    • BRAMY20245760//Araneus diadematus fibroin-4 mRNA, partial cds.
    • BRAWH20047790//HMG (high mobility group) box
    • BRSSN20005610//Mus musculus semaphorin cytoplasmic domain-associated protein 3A (Semcap3) mRNA, complete cds.
    • BRSSN20005660//Bacterial type II secretion system protein
    • BRSSN20093890//Homo sapiens mRNA for Kelch motif containing protein, complete cds.
    • CTONG20041150//Streptomyces ansochromogenes strain 7100 SanE (sanE) gene, complete cds.
    • CTONG20066110//Homo sapiens DEME-6 mRNA, partial cds.
    • CTONG20069420//Ribosomal protein S14p/S29e
    • CTONG20071040//BETA CRYSTALLIN B2 (BP).
    • CTONG20074170//DENN (AEX-3) domain
    • CTONG20083430//Nuclear transition protein 2
    • CTONG20170940//MYOTROPHIN (V-1 PROTEIN) (GRANULE CELL DIFFERENTIATION PROTEIN).
    • CTONG20174290//TRICHOHYALIN.
    • CTONG20174580//Homo sapiens mRNA for vascular Rab-GAP/TBC-containing protein complete cds.
    • CTONG20180690//Collagen triple helix repeat (20 copies)
    • CTONG20186550//cca3 protein—rat
    • CTONG20188080//TPR Domain
    • FCBBF10004760//Homo sapiens GAP-like protein (N61) mRNA, complete cds.
    • FCBBF20033360//RING CANAL PROTEIN (KELCH PROTEIN).
    • FCBBF20041380//SAM domain (Sterile alpha motif)
    • FCBBF20043730//UBA domain
    • FCBBF20056580//Mus musculus NSD1 protein mRNA, complete cds.
    • FCBBF20059660//TPR Domain
    • FCBBF30019180//SERINE/THREONINE PROTEIN PHOSPHATASE 2A, 65 KDA REGULATORY SUBUNIT A, ALPHA ISOFORM (PP2A, SUBUNIT A, PR65-ALPHA ISOFORM) (PP2A, SUBUNIT A, R1-ALPHA ISOFORM).
    • FCBBF30026580//Homo sapiens retinoblastoma-associated protein RAP140 mRNA, complete cds.
    • FCBBF30035570//C2 domain
    • FCBBF30079770//D-isomer specific 2-hydroxyacid dehydrogenases
    • FCBBF30100120//Mus musculus semaphorin cytoplasmic domain-associated protein 3A (Semcap3) mRNA, complete cds.
    • FCBBF30100410//Mus musculus testis-specific Y-encoded-like protein (Tspyl1) mRNA, complete cds.
    • FCBBF30118890//Drosophila melanogaster La related protein (larp) mRNA, partial cds.
    • FCBBF30138000//trg protein—rat
    • FCBBF30157270//Rattus norvegicus PAPIN mRNA, complete cds.
    • FCBBF30161780//gag gene protein p24 (core nucleocapsid protein)//Zinc knuckle
    • FCBBF30198670//dof protein—fruit fly (Drosophila melanogaster)
    • FCBBF30222910//Mus musculus Rap2 interacting protein 8 (RPIP8) mRNA, complete cds.
    • FCBBF30255680//Rattus norvegicus brain specific cortactin-binding protein CBP90 mRNA, partial cds.
    • FCBBF30260210//Drosophila melanogaster KISMET-L long isoform (kis) mRNA, complete cds.
    • FCBBF30282020//cca3 protein—rat
    • FCBBF40000610//late gestation lung 2 protein [Rattus norvegicus].
    • FEBRA20029620//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat
    • FEBRA20031150//Homo sapiens HSKM-B (HSKM-B) mRNA, complete cds.
    • FEBRA20038330//Corticotropin-releasing factor family
    • FEBRA20038970//Homo sapiens mRNA for stabilin-1 (stab1 gene).
    • FEBRA20088610//CELLULAR RETINALDEHYDE-BINDING PROTEIN (CRALBP).
    • FEBRA20150420//HYPOTHETICAL 131.5 KDA PROTEIN C02F12.7 IN CHROMOSOME X.
    • FEBRA20175330//D-isomer specific 2-hydroxyacid dehydrogenases
    • HEART10001420//Mus musculus skm-BOP1 (Bop) mRNA, complete cds.
    • HLUNG20024050//Rubredoxin
    • HLUNG20030420//Mus musculus mRNA for MAIL, complete cds.
    • HLUNG20030490//Ambystoma tigrinum RPE65 protein mRNA, complete cds.
    • HLUNG20033060//Homo sapiens GAP-like protein (N61) mRNA, complete cds.
    • HLUNG20041590//ubiquitous tetratricopeptide containing protein RoXaN [Homo sapiens].
    • HLUNG20045340//MOB2 PROTEIN (MPS1 BINDER 2).
    • HLUNG20051330//FHIPEP family
    • HLUNG20070410//Dihydropyridine sensitive L-type calcium channel (Beta subunit)
    • HLUNG20072100//Gallus gallus Dach2 protein (Dach2) mRNA, complete cds.
    • HLUNG20083480//Chicken mRNA for TSC-22 variant, complete cds, clone SLFEST52.
    • KIDNE20027980//SAM domain (Sterile alpha motif)
    • KIDNE20084730//Homo sapiens FH1/FH2 domain-containing protein FHOS (FHOS) mRNA, complete cds.
    • KIDNE20149780//NG28 [Mus musculus]
    • KIDNE20154330//Rattus norvegicus mRNA for multi PDZ domain protein.
    • KIDNE20170400//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Protein kinase C terminal domain//Rubredoxin
    • KIDNE20189890//Homo sapiens mRNA for KARP-1-binding protein 2 (KAB2), complete cds.
    • LIVER20010760//Homo sapiens C-type lectin-like receptor-1 mRNA, complete cds.
    • LIVER20040740//RETINAL-BINDING PROTEIN (RALBP).
    • MESAN20009090//Homo sapiens CEGP1 protein (CEGP1), mRNA
    • MESAN20026870//PAN domain//TBC domain
    • MESAN20090190//CEGP1 protein [Homo sapiens].
    • NT2NE20059680//Homo sapiens integrin cytoplasmic domain associated protein (Icap-1a) mRNA, complete cds.
    • NT2NE20077270//Adenovirus EB1 55K protein/large t-antigen
    • NT2NE20087850//ANTER-SPECIFIC PROLINE-RICH PROTEIN APG (PROTEIN CEX) (FRAGMENT).
    • NT2NE20095230//Homo sapiens HSKM-B (HSKM-B) mRNA, complete cds.
    • NT2NE20108420//KES1 PROTEIN.
    • NT2NE20173970//Rattus norvegicus beta-catenin binding protein mRNA, complete cds.
    • NT2NE20177210//Leishmania major partial ppg1 gene for proteophosphoglycan.
    • NT2RP70012830//CALPHOTIN.
    • NT2RP70035110//Caenorhabditis elegans UNC-89 (unc-89) gene, complete cds.
    • NTONG20002230//Mus musculus RW1 protein mRNA, complete cds.
    • NTONG20005310//Ribosomal protein S9/S16
    • NTONG20029850//CALCYPHOSINE (R2D5 ANTIGEN).
    • NTONG20035150//RING CANAL PROTEIN (KELCH PROTEIN).
    • NTONG20058220//Homo sapiens phosphoprotein pp75 mRNA, partial cds.
    • OCBBF20005220//Rattus norvegicus Fos-related antigen mRNA, complete cds.
    • OCBBF20011860//Mus musculus epithelial protein lost in neoplasm-a (Eplin) mRNA, complete cds.
    • OCBBF20016810//enhancer of polycomb [Mus musculus]
    • OCBBF20147070//DNA polymerase (viral) C-terminal domain
    • OCBBF20160380//liver stage antigen LSA-1—Plasmodium falciparum
    • OCBBF20177910//Corticotropin-releasing factor family
    • PEBLM20005020//Virion host shutoff protein
    • PLACE60055460//Homo sapiens leucine-zipper protein FKSG13 (FKSG13) mRNA, complete cds.
    • PLACE60068710//SUPPRESSOR PROTEIN SRP40.
    • PLACE60080360//mucin [Homo sapiens]
    • PLACE60082850//Pathogenesis-related protein Bet v I family
    • PLACE60098350//Human hepatocellular carcinoma associated protein (JCL-1) mRNA, complete cds.
    • PLACE60105680//Homo sapiens mRNA for TU12B1-TY, complete cds.
    • PLACE60119700//Homo sapiens mRNA for ABP32, complete cds.
    • PLACE60120280//SER/THR-RICH PROTEIN T10 IN DGCR REGION.
    • PLACE60132200//TRICHOHYALIN.
    • PLACE60181870//Pentaxin family
    • PROST20084470//Plasmodium berghei strain NYU2 merozoite surface protein-1 mRNA, partial cds.
    • PROST20087240//gag gene protein p24 (core nucleocapsid protein)
    • PROST20122490//Gallus gallus syndesmos mRNA, complete cds.
    • PROST20130320//S-100/ICaBP type calcium binding domain
    • PROST20152870//Homo sapiens APC2 gene, exon 14.
    • PUAEN10001640//Mus musculus cerebellar postnatal development protein-1 (Cpd1) mRNA, partial cds.
    • PUAEN20000800//Bleomycin resistance protein
    • SMINT20012220//Collagen triple helix repeat (20 copies)
    • SMINT20035510//Drosophila melanogaster La related protein (larp) mRNA, partial cds.
    • SMINT20036440//Drosophila melanogaster epsin-like protein mRNA, complete cds.
    • SMINT20038660//Homo sapiens HNOEL-iso (HNOEL-iso) mRNA, complete cds.
    • SMINT20043390//Ras association (RalGDS/AF-6) domain
    • SMINT20048720//Cytochrome P450//Cytochrome P450
    • SMINT20052130//Rattus norvegicus mRNA for gankyrin homologue, complete cds.
    • SMINT20054050//ABC1 PROTEIN HOMOLOG PRECURSOR.
    • SPLEN20024770//Rattus norvegicus (rsec6) mRNA, complete cds.
    • SPLEN20040780//CORNIFIN B (SMALL PROLINE-RICH PROTEIN 1B) (SPR1B) (SPR1 B).
    • SPLEN20041810//BC-2 protein [Homo sapiens]
    • SPLEN20100040//258.1 KDA PROTEIN C210RF5 (KIAA0933).
    • SPLEN20104150//Ribosomal protein L36
    • SPLEN20116720//Homo sapiens misato mRNA, partial cds.
    • SPLEN20176130//Homo sapiens mRNA for ALEX1, complete cds.
    • SPLEN20181570//TRICHOHYALIN.
    • TESTI20004310//TRICHOHYALIN.
    • TESTI20016970//TPR Domain
    • TESTI20030440//TRICHOHYALIN.
    • TESTI20043180//mouse mRNA for megakaryocyte potentiating factor, complete cds.
    • TESTI20043910//IQ calmodulin-binding motif//IQ calmodulin-binding motif//IQ calmodulin-binding motif//IQ calmodulin-binding motif//IQ calmodulin-binding motif
    • TESTI20044900//Strongylocentrotus purpuratus radial spokehead mRNA, complete cds.
    • TESTI20046110//Extracellular link domain
    • TESTI20047930//Homo sapiens NY-REN-2 antigen mRNA, complete cds.
    • TESTI20049410//Proprotein convertase P-domain
    • TESTI20053950//IQ calmodulin-binding motif
    • TESTI20054700//Streptococcus pneumoniae strain g375 surface protein PspC (pspC) gene, pspC-8.1 allele, complete cds.
    • TESTI20055880//Serum amyloid A protein
    • TESTI20056030//Homo sapiens 88-kDa Golgi protein (GM88) mRNA, complete cds.
    • TESTI20061090//Keratin, high sulfur B2 protein
    • TESTI20064370//TPR Domain//TPR Domain//TPR Domain//TPR Domain//Synaptobrevin
    • TESTI20084250//OXYSTEROL-BINDING PROTEIN.
    • TESTI20092170//ENV polyprotein (coat polyprotein)
    • TESTI20116050//UBX domain
    • TESTI20120500//Kelch motif//Kelch motif
    • TESTI20126280//Mus musculus STAP mRNA for sperm tail associated protein, complete cds.
    • TESTI20144390//TESTIS-SPECIFIC PROTEIN PBS13.
    • TESTI20165990//Ribosomal protein L36
    • TESTI20169500//HYPOTHETICAL 51.9 KDA PROTEIN C27F1.04C IN CHROMOSOME I.
    • TESTI20170280//Flagellar L-ring protein
    • TESTI20176450//thioredoxin interacting factor [Mus musculus].
    • TESTI20179230//Dihydropyridine sensitive L-type calcium channel (Beta subunit)
    • TESTI20180600//Homo sapiens HOM-TES-85 tumor antigen mRNA, complete cds.
    • TESTI20209050//HYPOTHETICAL 113.1 KDA PROTEIN IN PRE5-FET4 INTERGENIC REGION.
    • TESTI20210570//RETINAL-BINDING PROTEIN (RALBP).
    • TESTI20215310//Homo sapiens calcyclin binding protein mRNA, complete cds.
    • TESTI20247440//Human BLu protein testis isoform (BLu) mRNA, complete cds.
    • TESTI20249360//Homo sapiens DEME-6 mRNA, partial cds.
    • TESTI20250220//TRICHOHYALIN.
    • TESTI20251440//Rattus norvegicus (rsec6) mRNA, complete cds.
    • TESTI20255460//Mus musculus mRNA for MIWI (piwi), complete cds.
    • THYMU20009500//TPR Domain
    • THYMU20010180//MOB1 PROTEIN (MPS1 BINDER 1).
    • THYMU20013810//Human SEC7 homolog Tic (TIC) mRNA, complete cds.
    • THYMU20018250//TPR Domain
    • THYMU20026950//Mus musculus ROSA 26 transcription AS ROSA26AS mRNA, complete cds.
    • THYMU20028410//Mus musculus Pax transcription activation domain interacting protein PTIP mRNA, complete cds.
    • THYMU20030460//Homo sapiens tumor endothelial marker 7 precursor (TEM7) mRNA, complete cds.
    • THYMU20031330//Homo sapiens putative nucleotide binding protein mRNA, complete cds.
    • THYMU20052460//PHORBOLIN I (FRAGMENTS).
    • THYMU20055450//Zona pellucida-like domain
    • THYMU20083830//Homo sapiens angiostatin binding protein 1 mRNA, complete cds.
    • THYMU20139160//Uncharacterized protein family UPF0031
    • THYMU20151610//Homo sapiens antigen NY-CO-1 (NY-CO-1) mRNA, complete cds.
    • TRACH20093400//TRICHOHYALIN.
    • TRACH20104510//Uncharacterized protein family UPF0005
    • TRACH20122980//HYPOTHETICAL PROTEIN MJ0798.
    • TRACH20139280//PX domain
    • TRACH20164810//D-isomer specific 2-hydroxyacid dehydrogenases
    • TRACH20165540//Human alpha-1 type I collagen gene surrounding osteogenesis imperfecta OI type II deletion.
    • UTERU20051790//guanylate kinase-interacting protein 1 Maguin-1, membrane-associated—rat
    • UTERU20083020//Domain of unknown function DUF71
    • UTERU20121140//Rhodanese-like domain
    • UTERU20128560//26.4 KDA PROTEIN IN RUVC-ASPS INTERGENIC REGION.
    • UTERU20132620//AXONEME-ASSOCIATED PROTEIN MST101(2).
    • UTERU20134830//pellino (Drosophila) homolog 2 [Homo sapiens]
    • UTERU20181270//Zinc knuckle
  • Further, the reason is that a polypeptide does not always belong solely to a single category of the above-described functional categories, and therefore, a polypeptide may belong to any of the predicted functional categories. Besides, additional functions can be found for the clones classified into these functional categories by further analyses.
  • Since the polypeptide encoded by clones of the invention contains full-length amino acid sequence, it is possible to analyze its biological activity, and its effect on cellular conditions such as cell proliferation and differentiation by expressing the polypeptide as a recombinant polypeptide using an appropriate expression system, injecting the recombinant into the cell, or raising a specific antibody against the polypeptide.
  • The biological activities of respective polypeptides can be analyzed by the methods as shown below. Secretory protein, transmembrane protein:
      • ‘Ion Channels’ (Ed., R. H. Ashley, 1995) of “The Practical Approach Series” (IRL PRESS),
      • “Growth Factors” (Eds., I. McKay, I. Leigh, 1993),
      • “Extracellular Matrix” (Eds., M. A. Haralson, J. R. Hassell, 1995);
        Glycoprotein-Related Protein:
      • “Glycobiology” (Eds., M. Fukuda, A. Kobata, 1993) of “The Practical Approach Series” (IRL PRESS),
      • “Glycoprotein Analysis in Biomedicine” (Ed., Elizabeth F. Hounsell, 1993) of “Method in Molecular Biology” (Humana Press) series;
        Signal Transduction-Related Protein:
      • “Signal Transduction” (Ed., G. Milligan, 1992) of “The Practical Approach Series” (IRL PRESS),
      • “Protein Phosphorylation” (Ed., D. G. Hardie, 1993), or
      • “Signal Transduction Protocols” (Eds., David A. Kendall, Stephen J. Hill, 1995) of “Method in Molecular Biology” (Humana Press) series;
        Transcription-Related Protein:
      • “Gene Transcription” (Eds., B. D. Hames, S. J. Higgins, 1993) of “The Practical Approach Series” (IRL PRESS),
      • “Transcription Factors” (Ed., D. S. Latchman, 1993);
        Enzyme and/or Metabolism-Related Protein:
      • “Enzyme Assays” (Eds., ROBERT EISENTHAL and MICHAEL J. DANSON, 1992) of “The Practical Approach Series” (IRL PRESS);
        Cell Division and/or Cell Proliferation-Related Protein:
      • “Cell Growth, Differentiation and Senescence” (Ed., GEORGE STUDZINSKI, 2000) of “The Practical Approach Series” (IRL PRESS);
        Cytoskeleton-Related Protein:
      • “Cytoskeleton: Signalling and Cell Regulation” (Eds., KERMIT L. CARRAWAY and CAROLIE A. CAROTHERS CARRAWAY, 2000) of “The Practical Approach Series” (IRL PRESS),
      • “Cytoskeleton Methods and Protocols” (Ed., Gavin, Ray H., 2000) of “Method in Molecular Biology” (Humana Press) series;
        Nuclear Protein and/or RNA Synthesis-Related Protein:
      • “Nuclear Receptors” (Ed., DIDIER PICARD, 1999) of “The Practical Approach Series” (IRL PRESS),
      • “RNA Processing” (Eds., STEPHEN J. HIGGINS and B. DAVID HAMES, 1994);
        Protein Synthesis and/or Transport-Related Protein:
      • “Membrane Transport” (Ed., STEPHEN A. BALDWIN, 2000) of “The Practical Approach Series” (IRL PRESS),
      • “Protein Synthesis Methods and Protocols” (Eds., Martin, Robin, 1998) of “Method in Molecular Biology” (Humana Press) series;
        Cellular Defense-Related Protein:
      • “DNA Repair Protocols” (Henderson, Daryl S., 1999) of “Method in Molecular Biology” (Humana Press) series,
      • “Chaperonin Protocols” (Eds., Schneider, Christine, 2000);
        Development and/or Differentiation-Related Protein:
      • “Developmental Biology Protocols” (Eds., ROBERT EISENTHAL and MICHAEL J. DANSON, 1992) of “Method in Molecular Biology” (Humana Press) series;
        DNA- and/or RNA-Binding Protein:
      • “DNA-Protein Interactions Principles and Protocols” (Eds., Kneale, G. Geoff, 1994) of “Method in Molecular Biology” (Humana Press) series,
      • “RNA-Protein Interaction Protocols” (Eds., Haynes, Susan R., 1999);
        ATP- and/or GTP-Binding Protein:
      • “Signal Transduction Protocols” (Eds., David A. Kendall, Stephen J. Hill, 1995) of “Method in Molecular Biology” (Humana Press) series.
  • In the categorization, the clone predicted to belong to the category of secretory and/or membrane protein means a clone having hit data with some annotation, such as growth factor, cytokine, hormone, signal, transmembrane, membrane, extracellular matrix, receptor, G-protein coupled receptor, ionic channel, voltage-gated channel, calcium channel, cell adhesion, collagen, connective tissue, etc., suggesting that it was a secretory or membrane protein, or a clone in which the presence of nucleotide sequence encoding a signal sequence or transmembrane region was suggested by the results of PSORT and SOSUI analyses for deduced ORF.
  • The clone predicted to belong to the category of glycoprotein-related protein means a clone having hit data with some annotation, such as glycoprotein, suggesting that the clone encodes a glycoprotein-related protein.
  • The clone predicted to belong to the category of signal transduction-related protein means a clone having hit data with some annotation, such as serine/threonine-protein kinase, tyrosine-protein kinase, SH3 domain, SH2 domain, etc., suggesting that the clone encodes a signal transduction-related protein.
  • The clone predicted to belong to the category of transcription-related protein means a clone having hit data with some annotation, such as transcription regulation, zinc finger, homeobox, etc., suggesting that the clone encodes a transcription-related protein.
  • The clone predicted to belong to the category of disease-related protein means a clone having hit data with some annotation, such as disease mutation, syndrome, etc., suggesting that the clone encodes a disease-related protein, or a clone whose full-length nucleotide sequence has hit data for Swiss-Prot, GenBank, UniGene, or nr, where the hit data corresponds to genes or polypeptides which have been deposited in the Online Mendelian Inheritance in Man (OMIM) (http://www.ncbi.nlm.nih.gov/Omim/), which is the human gene and disease database described later.
  • The clone predicted to belong to the category of enzyme and/or metabolism-related protein means a clone having hit data with some annotation, such as metabolism, oxidoreductase, E. C. No. (Enzyme commission number), etc., suggesting that the clone encodes an enzyme and/or metabolism-related protein.
  • The clone predicted to belong to the category of cell division and/or cell proliferation-related protein means a clone having hit data with some annotation, such as cell division, cell cycle, mitosis, chromosomal protein, cell growth, apoptosis, etc., suggesting that the clone encodes a cell division and/or cell proliferation-related protein.
  • The clone predicted to belong to the category of cytoskeleton-related protein means a clone having hit data with some annotation, such as structural protein, cytoskeleton, actin-binding, microtubles, etc., suggesting that the clone encodes a cytoskeleton-related protein.
  • The clone predicted to belong to the category of nuclear protein and/or RNA synthesis-related protein means a clone having hit data with some annotation, such as nuclear protein, RNA splicing, RNA processing, RNA helicase, polyadenylation, etc., suggesting that the clone encodes a nuclear protein and/or RNA synthesis-related protein.
  • The clone predicted to belong to the category of protein synthesis and/or transport-related protein means a clone having hit data with some annotation, such as translation regulation, protein biosynthesis, amino-acid biosynthesis, ribosomal protein, protein transport, signal recognition particle, etc., suggesting that the clone encodes a protein synthesis and/or transport-related protein.
  • The clone predicted to belong to the category of cellular defense-related protein means a clone having hit data with some annotation, such as heat shock, DNA repair, DNA damage, etc., suggesting that the clone encodes a cellular defense-related protein.
  • The clone predicted to belong to the category of development and/or differentiation-related proteins means a clone having hit data with some annotation, such as developmental protein, etc., suggesting that the clone encodes a development and/or differentiation-related protein.
  • The clone predicted to belong to the category of DNA- and/or RNA-binding protein means a clone having hit data with some annotation, such as DNA-binding, RNA-binding, etc.
  • The clone predicted to belong to the category of ATP-and/or GTP-binding protein means a clone having hit data with some annotation, such as ATP-binding, GTP-binding, etc.
  • As to a protein involved in a disease, it is possible to perform a functional analysis as described above, but also possible to analyze correlation between the expression or the activity of the protein and a certain disease by using a specific antibody that is obtained by using expressed protein. Alternatively, it is possible to utilize the database OMIM, which is a database of human genes and diseases, to analyze the protein. Further, new information is constantly being deposited in the OMIM database. Therefore, it is possible for one skilled in the art to find a new relationship between a particular disease and a gene of the present invention in the most up-to-date database. The proteins involved in diseases are useful for developing a diagnostic marker or medicines for regulation of their expression and activity, or as a target of gene therapy.
  • Also, as for a secretory protein, membrane protein, signal transduction-related protein, glycoprotein-related protein, or transcription-related protein, etc., search of the OMIM with the following keywords resulted in the finding that the proteins are involved in many diseases (the result of the OMIM search for secrete and membrane proteins is shown below). Also, association between proteins related to signal transduction or transcription and diseases is reported in “Transcription Factor Research-1999” (Fujii, Tamura, Morohashi, Kageyama, and Satake edit, (1999) Jikken-Igaku Zoukan, Vol. 17, No. 3), and “Gene Medicine”, (1999) Vol. 3, No. 2). When cancer is used as an example, as described in “Biology of Cancer” (S. Matsubara, 1992) of Life Science series (Shokabo), many proteins are involved in cancers, which include enzyme and/or metabolism-related proteins, cytoskeleton-related proteins, cell division and/or cell proliferation-related proteins as well as secretory proteins, membrane proteins, signal transduction-related proteins, glycoprotein-related proteins, transcription-related proteins. As clearly seen by the above example, it is evident that not only disease-related proteins but also secretory proteins, membrane proteins, signal transduction-related proteins, glycoprotein-related proteins, transcription-related proteins, etc. are often involved in diseases, and thus they can be useful targets in the field of medical industry.
  • The result of the OMIM search for secretory and membrane proteins is shown below, in which the keywords,
      • (1) secretion protein,
      • (2) membrane protein,
      • (3) channel, and
      • (4) extracellular matrix were used.
  • Shown in the search result are only the accession numbers in the OMIM. Using the number, data showing the relationship between a disease and a gene or protein can be seen. The OMIM data has been renewed everyday.
  • 1) Secretion Protein
  • 354 entries found, searching for “secretion protein”
    *604667, *104760, *176860, *151675, *139320, *107400, *604029,
    *118910, #200100, *176880, *603850, *147572, *604028, *179513,
    *125950, *139250, *246700, *600946, *600560, *602926, 185860,
    *605083, *603215, *602421, *157147, *179512, *600174, *109270,
    *604710, *138120, *179510, *600998, *179509, *170280, *179511,
    *600626, *603831, *601489, *154545, *179490,
    *603826, *122559, *603216, *102720, *147290, *164160, *603062,
    *112262, *602672, *605435, *605322, *131230, *601652, *603166,
    *601746, *601591, *179508, #160900, *104311, *600759, *147545,
    *167805, #104300, *167770, #219700, *168470, *601684, *602049,
    *601146, *605227, *602434, *602534, *114840, *603489, *604323,
    *107470, *600753, *600768, *118825, *600564,
    *604252, *173120, *134370, *192340, *308230, *600322, *605359,
    *600046, *300090, 106160, *600041, #262500, *605563, *150390,
    *158106, *182590, #103580, *104610, #173900, *134797, *143890,
    #145980, *306900, *308700, *176300, *227500, *137350, #154700,
    *138079, *600760, *107730, *142410, *147670, *124092, *590050,
    *152760, *600509, *605646, *201910, *227600,
    *152790, *300200, *300300, 300800, *138160, *107741, *120150,
    *601199, *120180, *120160, *176730, *133170, *122560, *107300,
    *137241, *120140, *101000, *193400, *217000, *272800, *600937,
    #201710, *600377, #174800, *106100, #274600, *173350, #177170,
    *147620, *214500, *131244, *202110, *120120, *601007, *191160,
    *147470, *603372, *600733, *252800, *190160,
    *138040, *158070, *162151, #125700, #130070, *113811, *603355,
    *171060, *136435, #184700, *603732, *190180, *164008, *186590,
    *120220, *604312, *152200, *138130, *605085, *605353, *600840,
    #166210, *188545, *207750, *173360, *601933, #194050, *153450,
    *138850, *253200, *307030, *157145, *600514, *600262, *264080,
    *147380, *600281, #204000, #227810, *232200,
    *188826, *232800, *161561, #166200, *188400, *153620, *182099,
    *218040, #265800, *172400, #177200, *176805, #211600, #214700,
    #176410, *152780, *600633, *601771, *301500, *605402, *601922,
    *307800, *147892, *147720, *312060, #520000, *147660, *106150,
    *602358, *107270, *601769, *147440, *604558, *131530, *600270,
    *601610, *603692, *603401, *600423, *601604,
    *603345, #125853, *602843, *142640, *603044, *605740, *134830,
    *602779, *130660, *139191, *137035, *600761, *601340, *600823,
    *107740, *130160, *600877, *605110, *600945, *130080, *600957,
    #130050, *605580, *118444, *601124, *124020, 122470, *120700,
    *603201, *137216, *601185, *138945, *218030, *600839, #240600,
    #262400, #162300, *162330, *188450, #265850,
    *263200, *162641, *300159, *601038, #191390, *201810, *601398,
    *602384, *131240, *602423, *139392, *142703, *602663, *232700,
    *602682, #602722, *602730, *600734, *188540, *182452, *601538,
    *603061, *146880, *603140, *603160, *142704, #252650, *182280,
    *125255, *603252, #131750, *182139, *182100, #259420, #261100,
    *603493, *601745, *182098, *603795, *123812,
    *600264, *147940, *180246, *180245, *118888, #604284, *168450,
    *118455, *604398, *604433, *601919, *118445, *600031, *604961,
    *605032, *605033, *171050, #171300, *131243, *109160, *605254,
    274900, #171400, *600042, *151670, *184600, *605470, *605546,
    *176760, *602008, *102200, *605720, *600732, *605901

    2) Membrane Protein
  • 1489 entries found, searching for “membrane protein”
    *130500, *605704, *305360, *153330, *173610, *109270, *170995,
    *170993, *104776, *602333, *309060, *605703, *120920, *605943,
    *602690, *159430, *600897, *133090, *601178, *602413, *602003,
    *604405, *605940, *603237, *109280, *600378, *602173, *107776,
    *602334, *602335, *125305, *601134, *309845, *605731, *154045,
    *603241, *603718, *600594, *603214, *185881,
    *603657, *600182, *603177, *605331, *601476, *605456, *601114,
    *605190, *600723, *603904, *136950, *300222, *602879, *185880,
    *605348, *300096, *602257, *177070, *310200, *603062, *603344,
    *600039, *602977, *300100, *128240, *600959, *600322, *227400,
    *186945, *600946, *602534, *602048, *182900, *601097, *600267,
    *602625, *136430, *602421, *601047, *107450,
    *143450, *603141, *184756, *164730, *159440, *154050, *600579,
    *312080, *604202, *603700, *600447, *256540, *604691, *158343,
    *600403, *602414, *137290, *176640, *176981, *600179, *600754,
    *604456, *604693, *605875, *604605, *188860, *300172, *602910,
    *604323, *219800, *601848, *603179, *600279, *602251, #222700,
    *603831, *605072, *605377, *601028, *604155,
    *108733, *104225, *601896, *601510, *173335, *107770, *601767,
    *600046, *603850, *600040, *603784, *603234, 188560, *605863,
    *121015, *605862, *605861, *186946, *604252, *603215, *142461,
    *604597, *603143, *605264, *603735, *176860, *605536, *176801,
    *180721, *603355, *104760, *131560, *310300, *602631, *304700,
    #309400, *603142, *143890, *605431, *600753,
    *115501, *176790, *600266, *601691, *168468, *601239, *602216,
    #104300, *605613, *601595, *605550, *125950, *605475, *602217,
    *602261, *603534, *602262, *604631, *190315, *601313, *604306,
    *104311, *604672, *605000, *602461, *605548, *602296, *604376,
    *121014, *121011, *600691, *604262, *139310, *304040, *605445,
    *179514, *179512, *151460, #160900, *120130,
    *128239, *601158, *601403, *176943, *601014, 300800, *300294,
    *601757, *185470, *273800, *605034, *602887, #185000, *604871,
    *603593, *603583, *605454, *104775, *605872, *141180, *602713,
    *603531, *139150, *601531, *601832, *605452, *134651, *604156,
    *120620, *605883, *604142, *166945, *605324, *600816, *604699,
    *300112, *605182, *600164, *182180, *605071,
    *300023, *605057, *308240, *300249, *176947, *176894, *605081,
    *605035, *602044, *182860, *107271, *305100, *153390, *113730,
    *602689, *180069, *603518, *300017, *191275, *177061, *601693,
    *601789, *604241, *600934, *138160, *604424, *603868, *600174,
    *600718, *600523, *604141, *601009, *605251, *600481, *600874,
    *155550, *605227, *601017, *162230, 601138,
    *604157, *601212, *600763, *604110, *604158, *601107, *601326,
    600621, *600587, 601137, *600917, *600855, *605058, *194355,
    *605194, *603291, *102720, *136425, *170715, *603216, *605547,
    *135630, *602926, *600168, *605002, *602474, *600157, *603025,
    *603893, *231200, *120090, *601966, *131230, *604722, *604721,
    *604515, *246700, *602101, *605628, *303630,
    *605787, *602857, *602285, *605708, *602488, *605025, *603817,
    *300051, *603293, *176878, *603646, 605707, 185860, *112205,
    *300187, *602654, *120070, *603648, *604850, *602655, *602514,
    *300118, *182309, *179590, *602701, *600759, *204200, *604170,
    *175100, #103580, *147670, *306400, *143100, *182870, *257220,
    *180380, #116920, *301000, *193300, *157147,
    *131550, *139200, *139130, *190195, *605406, *155760, *155960,
    *605734, *155970, *605385, *111700, *155975, *150370, 605709,
    *151430, *605438, *151510, *116952, *157655, *158105, *605777,
    *176877, *153619, *120131, *185430, *109190, *120190, *109170,
    *605093, *605250, *153432, *107777, *186590, *160993, *605699,
    *605698, *605813, *605697, *605616, *605300,
    *162060, *605219, *163970, *135620, *165040, *605478, *604964,
    *103195, *604932, *604923, *605906, *605496, *605914, *166490,
    138277, *604915, *114070, *605213, *605933, *180297, *101000,
    *191163, *191164, *605101, *603167, *600772, *603164, *600708,
    *604001, *191328, *313440, *602672, *604009, *604299, *192974,
    *604256, *603048, *600515, *604221, *602632,
    *604196, *601179, 603290, *604661, *601023, *601110, *304800,
    *203200, *300212, *602933, *603352, *208900, *604418, *604838,
    *600551, #212140, *604837, *602049, *600552, *600553, *300213,
    *602574, *600583, *600932, *603452, *604775, *516020, *604617,
    *604464, *603498, *300145, *601523, *602694, *600632, *604762,
    *604492, *400015, *604504, *601717, *601728,
    *300242, *602426, *604194, *603821, *604730, *600695, *603823,
    *603869, *300241, *600707, *603822, *602370, *602202, *604193,
    *601181, *604089, *602507, *604195, *602306, *300284, *601805,
    *601895, *601275, *604660, *600752, *603820, *604192, *602207,
    *308230, *600894, *312600, *603199, *604029, *602500, *102680,
    *235200, #256300, *601633, #219700, 262890,
    *156225, *173470, *193400, *173910, *600354, *113705, *600065,
    *107741, *107400, *600024, *131195, *113811, #118220, *601638,
    *300011, *276903, *604144, *311770, *601758, #173900, *604592,
    *120120, *179605, *603130, *603372, *110750, *222900, *602509,
    *256100, *602469, *602281, *229300, *224100, *110900, *190180,
    *261600, *602997, *603616, *603189, 601791,
    *601567, *312700, *171060, *308700, *604027, *162643, *516000,
    *176261, *604028, *314850, #145980, *601383, *600930, *305900,
    *601253, *136350, *605537, *138140, *604033, *605070, *139250,
    *300500, *603967, *300041, *603866, #130600, *120150, *601050,
    *604942, *605204, *605248, *272750, *600163, *604235, *600682,
    *107266, *306900, *191092, #262500, *600106,
    *152790, *186720, *227650, *153700, *308380, *$$03390, *605646,
    *164920, *604478, #252650, *173850, *173350, *602505, *246530,
    *194380, *602575, *603030, #209920, *212138, #214100, *605767,
    *600582, *189980, #176200, *604653, *604678, *256550, *300037,
    *253700, #253300, #226700, *604766, #244400, *190000, *188040,
    *604824, *214500, #237500, *232300, *605014,
    *604477, *190930, *605124, *604475, *604594, #227810, *306700,
    #301050, *600135, *600143, *605145, #2699$$0, *300104, *277900,
    *300135, *300231, *192500, *182138, *191190, *176805, *600185,
    *186591, *604889, *603051, *165360, *147545, *601040, #156575,
    *107269, *603009, *602934, *123825, *60$$081, *602924, *163890,
    *600381, *602909, *150330, *109690, *1$$3900,
    *603434, *603491, *110700, *602581, *125647, #154700, *114760,
    *141900, *603690, *120220, *601199, #145500, *601309, *602382,
    *120325, *600877, *604205, *604090, 601497, *602377, *605464,
    *138720, *603728, *120950, *604026, *600580, *601610, *137167,
    *603960, *603931, *601880, *603126, *138190, *130130, *601997,
    *601975, *600395, *516040, *600418, *600650,
    *605245, *605172, *600509, *16476$$, *310400, *600308, *605109,
    *600544, *600359, *600103, *6052$$7, *312610, *176100, *308100,
    *158070, *605123, *173325, #312$$50, *600839, *158120, #604369,
    *604465, *173510, #161200, *151525, *605369, *604237, *516050,
    #600886, *604517, *165180, *605381, *605399, *307800, *604365,
    *155740, *147795, 601709, *604673, *147730,
    *602122, *147557, *193245, *600978, *604990, *603261, *603274,
    *601007, *131100, *602941, *107941, *146710, *276901, *131244,
    *602872, *603411, *186357, *176290, *601066, *185050, *232200,
    *143030, *601843, #236700, *604122, *142800, *134638, *604985,
    *182380, *603930, *142410, *137060, *604586, *601193, *120650,
    *252500, *253800, *120930, *604858, *605874,
    601274, *602158, *605873, *193210, *203100, *601295, *604095,
    #201710, *126150, *108740, #205400, *601373, *300167, *109545,
    *602894, *603361, #300257, *266200, *603401, *131390, *180470,
    *605908, *604798, #221770, *223360, *180901, *605641, *605745,
    *604018, *300200, *604603, *230800, *602676, #604004, *605692,
    *602640, *601599, *134637, *245900, *118425,
    601614, *605725, *120110, *300189, *300035, *603102, *250800,
    *602282, *602458, *123610, *603754, *300278, *601463, *300224,
    *601581, *182160, *601653, *139191, *601733, *600748, *142460,
    *601194, *152390, *153620, *601615, *601814, *601617, *601613,
    *300191, #308300, *600798, 601858, *601872, *601597, #601588,
    *600821, *147840, *152427, *138850, *600823,
    *601492, *300256, *600840, *300267, *601411, *139080, *139090,
    600851, *300334, *179080, *602095, *601284, *601282, #177200,
    *601681, *601252, *176000, *602184, *602188, #266510, #154020,
    *186711, *257200, *601711, *600667, *602241, *186745, *255125,
    *300126, *600644, *123890, #255120, #175200, *600004, *302060,
    *123580, *186760, *122561, *602316, *600017,
    *120940, 140300, *151690, *120700, *602354, *600019, *600857,
    *182175, *600536, *158380, *600516, *120290, *600493, *182310,
    #252010, *182530, *186830, *601839, *142790, *159465, *118990,
    *250790, *248600, #248250, *186845, *601153, *142600, *116930,
    *114860, *171834, #303600, *186880, *600444, *142871, *601852,
    *602602, *602607, *114207, *186910, #232220,
    600880, *134635, *112203, #112100, *111680, *231680, *311030,
    *111250, *111200, *134390, #226670, #145600, *226200, *602714,
    *171760, *133550, *602727, *161555, *602744, *602746, #131705,
    *602835, *600423, *176267, *602859, #600918, 277175, *602874,
    *601020, *109770, *600170, *217070, *173515, *602893, *147280,
    *154360, *171050, *108780, *176257, *600979,
    *600377, *108360, *204500, *170260, *146880, *154582, *601011,
    *600997, *602992, *201475, *603005, *190198, *147360, #270400,
    *600238, #164970, *306250, #126600, *193065, #181350, *106180,
    *602136, *600937, *603086, *603087, *307030, *182099, *103320,
    *601683, #192430, *103180, *102681, *192321, *600244, *191740,
    *191315, *603152, *102642, *191305, #266140,
    *100500, *600867, *604585, *604404, *604345, *603201, *605430,
    *603207, *603208, *605433, *604101, *603969, *605896, *604616,
    *605851, *605768, *604576, *605754, *605730, *605477, *603263,
    *605538, *603283, *604402, *605453, *605427, *603302, *605458,
    603313, *604415, *603345, *605541, *603353, *605295, *603879,
    *605268, *605266, *605246, *603377, *603380,
    *605181, *604203, *603425, *603867, *605106, *605017, *603842,
    *604936, *603510, *604857, *605932, *605816, *603765, *603551,
    *605357, *605237, *604204, *603594, *605110, *604190, *603861,
    *604962, *603639, *603644, *605007, *605349, *604943, *604918,
    *604907, *603667, *603681, *605396, *605561, *603712, *603713,
    *605688, *605942, *604878, *604843, *604659,
    *604671, *603798, *604682, *604056, *604705, *603749, 602586,
    *603647, *602515, #602475, *603717, *602359, *602372, *602380,
    *602518, *603652, *602573, *603626, 602587, *603598, *602871,
    *603613, *603750, *603875, *602608, *602666, *602345, *602935,
    *603564, *603548, *603927, 601876, *602343, *603943, *603787,
    *601730, *601611, *602679, *603788, *602243,
    603790, *601535, *603796, *601488, *601485, *602314, *601478,
    *604047, *604048, *602297, *604057, *602715, *602192, *601459,
    *601416, *603833, *602190, *604102, *602106, *604111, *602724,
    *603499, *602736, *601123, *601002, *600923, *601987, *604149,
    *601929, *600910, *600900, *600864, *604165, *600782, *602836,
    *600769, *600742, *602783, *601905, *600535,
    *604198, *601901, *600534, *602876, *603356, *600530, *604216,
    *604217, *602890, *602905, *600465, *600464, *600446, *602891,
    *603366, *601894, *604272, *603926, *603312, *600368, *602914,
    *600327, *603151, *603202, 602911, *602974, *603006, *601883,
    *603008, *600074, *603007, *603046, #603903, *604433, *600016,
    *603925, *516005, *516004, *516003, *601756,
    *604487, *516001, *313475, *313470, #307810, *604527, *604528,
    *601745, *604551, *604555, *603243, *603242, *603061, *603063,
    *603217, *300335, *300283, *300281, *604600, *300197, *603097,
    *603220, *601625, *604623, *603118, *601590, *604646, *300008,
    *601568, *300007, *275630, *601533, #275200, *270200, #261550,
    *604031, *604683, #254800, *251100, #242300,
    *604058, *604720, *240500, *233690, #232240, #226730, *223100,
    *222100, #220100, *216950, *604832, 212750, 212067, *604066,
    *193067, 601315, *193001, *604862, *604870, *191306, *600385,
    *604879, *191191, *601296, *604914, *190181, *604119, #188550,
    *604925, *188410, #601287, *604939, *188380, *604126, *604945,
    *604148, *188060, *604982, *186854, *604988,
    *186360, *186355, *185250, *600916, *605008, *605009, 185020,
    *600734, *605024, *182331, *605032, *605033, *182305, *180903,
    #179800, *179610, *605060, *179410, *178990, *176802, *605080,
    *176266, *176263, *176260, *600732, *173490, *604199, *173445,
    *173391, 172290, *605147, *605149, *171890, *600528, *171833,
    *605185, #170500, *605193, #168000, *605196,
    *167055, *605205, *605208, 166900, *605216, *162651, *162010,
    *600504, #161400, *604253, #160800, *159460, *154540, *605254,
    *605261, *153634, *600429, *153337, *600424, *605292, #604286,
    #152700, 152423, *152310, *151625, *600153, *604313, *151523,
    *150325, *150320, *150292, *603150, *150290, *150210, *605410,
    *605415, *605416, *605417, *605421, *603149,
    *604349, *147940, *600282, *147880, *146928, *146661, *600150,
    *146630, *142622, *600018, *605461, *138981, *138590, *600023,
    *138330, *605495, *138297, *605512, *138230, #136900, #301310,
    *516006, *605545, *605546, *136131, *134660, *134350, *516002,
    *605589, *131235, #130050, *605625, *126455, *126064, #125310,
    *605670, *604534, *125240, *123836, *123830,
    *123620, *605702, #122200, *120980, *120360, *118510, *114835,
    *605710, *605716, *605722, *114217, *604561, *113810, *111740,
    #110800, *605748, *605752, *604564, *110600, *603160, *109610,
    *605784, #107480, *107273, *603192, *300169, *106195, *105210,
    *104615, *104614, *104210, *103850, 103581, *605876, *605877,
    *605879, *103220, *605887, *300150, *102910,
    *102670, *102576, *605916, *604629, *102575, *102573, *300132,
    *101800, *605947

    3) Channel (Member of Membrane Protein)
  • 361 entries found, searching for “channel”
    *176266, *600724, *182390, *123825, *114208, *114206, *176267,
    *114205, *601784, *600937, *114204, *603415, *600053, *114207,
    *114209, *605427, *604527, *604528, *600760, *601011, *192500,
    *118425, *600228, *176261, *602235, *600761, *600359, *300008,
    *182389, *600877, *602232, *176263, *182391, *601328, *600054,
    *603939, *602208, *601534, *600504, *602323,
    *603208, *601958, *603537, *601012, *601327, *600734, *602780,
    *602781, *604433, *603220, *182392, *605874, *605873, *601745,
    *603888, *603219, *602604, *603796, *302910, *602866, *601013,
    *602905, *602906, *603967, *600163, #170500, *152427, *180901,
    *176260, #601462, *603951, *601141, *604492, *600702, *602023,
    *600308, *602754, *107776, *176257, *602024,
    *601949, *605222, *601142, *602983, *193245, *600681, *176265,
    *600235, *176262, *176258, *605206, *604427, *605411, *603305,
    *601219, *600150, *604065, *602343, *605223, *605720, *603906,
    *138249, *138253, *600843, *604385, *600003, *600935, *603940,
    *602727, *602158, 602911, *600397, *602726, *600845, *605080,
    *600580, *602872, *602106, *176264, *603953,
    *605722, *300110, *138252, *604111, *602717, *602420, *600570,
    600844, *603493, *600932, *605716, *138254, *603652, *300138,
    *605410, *176268, *605214, *605696, *300334, *604660, *176256,
    *605879, *603749, *603583, *602345, *604661, *603787, 603313,
    *602982, *604337, *600846, *604662, *300328, *300281, *602566,
    *602836, *604003, *603788, *603651, *602421,
    *107777, #177200, *100725, #219700, *100690, *100710, #160800,
    #603830, #183086, *600509, #220400, #601144, *173910, *180902,
    *605692, #264350, #160900, #145600, #255700, *602076, *603061,
    *601313, *154275, #604233, *604532, #108500, #121201, #170400,
    *300225, *121014, *139311, #125800, #160120, *118503, 601439,
    #141500, #168300, *304040, #601887, #256450,
    *186945, *154276, #300009, #216900, *600040, *601014, *601042,
    *602512, *601383, *605445, *602368, *603831, #117000, *601218,
    *108745, *605248, #177735, #173900, *601212, *182139, *601059,
    *600039, *601485, *180903, *186360, *603319, #600101, *118509,
    *600109, #121200, *600170, *604187, *176975, *137163, #310468,
    #263800, #262300, *603750, *600229, *124030,
    *602251, #603829, *137143, #145500, *600669, *147450, *154050,
    *603353, *600516, *601157, *600855, *601154, *602522, *249210,
    *600968, #252650, *171060, *600919, *156490, #259700, #601678,
    *601764, #310500, *131244, *300041, *121011, *125950, *114180,
    *602974, *600637, *113730, *118504, *605145, *604669, *118800,
    *121013, *121015, *138491, *600421, *104610,
    *604045, *604594, *131230, *605487, *138247, *600467, #602485,
    *602481, *138251, *137192, *602403, 600851, *277900, *603785,
    *603152, *603199, *603475, #168600, #272120, *170280, *603852,
    #241200, *603053, *600465, #603034, *142461, *164920, *137164,
    *600884, *600442, *123885, *604001, *600232, *232200, *171050,
    *602103, *602014, *300211, *600983, *602887,
    *604415, *604418, *300242, #300071, *604471, *600837, 168350,
    *118511, 193007, *600300, *604654, #601820, *180297, *600046,
    *603853, *604678, *604693, #604772, *118508, *603855, *605204,
    #254210, *182099, *182307, #130600, *601109, *114080, *300103,
    *182860, *605438, *601129, *603964, *600019, *516060, #185000,
    *138079, *104210, *605818, *603418, *305990, *305450

    4) Extracellular Matrix
  • 218 entries found, searching for “extracellular matrix”
    *605912, *603479, *602201, *604633, *601418, *601548, *115437,
    *154870, *600754, *602261, *602285, *602262, *134797, *120361,
    *604629, *604871, *603321, *603320, *601807, #154700, *116935,
    *185261, *120360, *185250, *605470, *603767, *253700, *190180,
    *128239, *308700, *276901, *193300, *120324, *188826, *602109,
    *155760, *600514, *600261, #177170, *600536,
    *147557, #116920, *150240, *601313, *120140, 601614, *605158,
    *120150, *120180, #200610, *605127, *193400, *192240, #173900,
    *152200, #136900, *135821, #130070, *120320, *120220, *112260,
    *310200, *600900, *600262, *605670, *600985, *179590, #245150,
    *602574, *601463, 183850, *601211, *604241, *600758, *186745,
    *604710, *602369, *602090, *190182, *192975,
    *602178, *230740, *600065, *601652, *158106, *190181, *156790,
    #158810, *193210, *155120, *192977, *193065, #226700, *187380,
    *231050, *182120, *188060, *186355, 163200, *164010, #156550,
    *151510, *150370, *253800, *156225, *150325, #194050, *150290,
    *216550, *147620, *600215, *222600, *147559, *165380, *182888,
    *600491, *146650, *146640, *600564, *600596,
    *600616, *600700, *600742, *138297, *182889, *154705, *600930,
    *301870, *153619, *601050, *601090, *601105, *165070, *305370,
    *135820, *130660, *310300, *601492, *128240, *601587, #126600,
    *601636, *600119, *601692, *601728, *125485, 601858, *601915,
    *602048, *175100, *602108, *121010, *600245, *120470, *120328,
    *120325, *602264, *120280, *602366, *600309,
    *602402, *602415, *602428, *602453, *602505, #166210, *602600,
    *602941, *603005, *603196, 603209, *603221, *603234, *603319,
    *120250, *120210, *120120, *603489, *603551, *118938, *603799,
    *603842, *603924, *603963, *604042, *604063, *604149, *604160,
    *601028, *604467, *604510, *604592, *116930, *116806, *601284,
    *604724, *604806, *604807, *604808, *107269,
    *605007, *605008, *605009, *600214, *600076, *605174, *605175,
    *605292, *605343, *605351, #600204, *605497, *605546, *605587,
    *605623, *600211, *605702, *103320
  • In addition to these, the various keywords shown in the above-mentioned categorization or others can be used for the OMIM search and the result may suggest the involvement thereof in diseases.
  • Further, the use of nucleotide sequences of cDNAs of the present invention enables analyzing the expression frequency of genes corresponding to the cDNAs. In addition, functions of the genes can be predicted based on the information obtained by the expression frequency analysis.
  • There are several methods for analyzing the expression levels of genes involved in diseases. Differences in gene expression levels between diseased and normal tissues are studied by the analytical methods using, for example, Northern hybridization, RT-PCR, DNA microarray, etc. (Experimental Medicine, Vol. 17, No. 8, 980-1056 (1999); Cell Engineering (additional volume) DNA Microarray and Advanced PCR Methods, Muramatsu & Nawa (eds.), Shujunsya (2000)). By computer analysis, in addition to these analysis methods, the nucleotide sequences of expressed genes can be compared to analyze the expression frequency. For example, there is a database called “BODYMAP”; gene clones are extracted at random from cDNA libraries of various tissues and/or cells, and the clones homologous to one another are assigned to a single cluster based on the information of nucleotide sequence homology at the 3′-end; genes are classified into any clusters, and the numbers of clones in the respective clusters are compared to gain the information on expression frequency (http://bodymap.ims.u-tokyo.ac.jp/).
  • When explicit difference in the expression levels between diseased tissues and normal tissues is observed for a gene by these analytical methods, it can be conclude that the gene is closely involved in a disease or disorder. Instead of diseased tissues, when gene expression is explicitly different between normal cells and cells reproducing disease-associated specific features, it can be concluded that the gene is closely involved in a disease or disorder.
  • From the 1970 clones whose full-length nucleotide sequences had been revealed, genes involved in particular pathology or functions were selected by the use of databases shown below (see Example 7; “Expression frequency analysis in silico”). The database used in the analyses of the present invention contains nucleotide sequences of 770,546 clones, and the population of the database is large enough for the analysis. The sequence information in the database was obtained by selecting cDNA clones at random from cDNA libraries derived from the various tissues and cells shown in Example 1 and determining the 5′-end sequences thereof.
  • Then, the nucleotide sequences of respective clones in this database were categorized (clustered) based on the nucleotide sequence homology determined with a search program; the number of clones belonging to every cluster of each library was determined and normalized; thus, the ratio of a certain gene in a cDNA library was determined. This analysis provided the information of the expression frequency of a gene in a tissue or cell that is the source of the cDNA library.
  • Then, in order to analyze the expression of genes corresponding to the nucleotide sequences of cDNAs of the present invention in tissues and cells, the libraries from the tissues or cells, which had been used in the large-scale cDNA analyses, were taken as subjects to compare the expression levels between different tissues or cells. Namely, the expression frequency was analyzed by comparing the previously normalized values between tissues or cells from which 600 or more cDNA clones whose nucleotide sequences had been analyzed were derived. The result of this analysis showed that the cDNA clones corresponded to the genes involved in the pathology and functions, which are indicated below. Each value in Tables 3 to 39 indicated below represents a relative expression frequency; the higher the value, the higher the expression level.
  • Osteoporosis-Related Genes
  • Osteoporosis is a pathology in which bones are easily broken owing to overall decrease in components of bone. The onset correlates to the balance between the functions of osteoblast producing bone and osteoclast absorbing bone, namely bone metabolism. Thus, the genes involved in the increase of osteoclasts differentiating from precursor cells of monocyte/macrophage line (Molecular Medicine 38. 642-648. (2001)) are genes involved in osteoporosis relevant to bone metabolism.
  • A nucleotide sequence information-based analysis was carried out to identify the genes whose expression frequencies are higher or lower in CD34+ cell (cell expressing a glycoprotein CD34) treated with the osteoclast differentiation factor (Molecular Medicine 38. 642-648. (2001)) than in the untreated CD34+ cell, which is the precursor cell of monocyte/macrophage line. The result of comparative analysis for the frequency between the cDNA libraries prepared from the RNA of CD34+ cells (CD34C) and from the RNA of CD34+ cells treated with the osteoclast differentiation factor (D30ST, D60ST or D90ST) showed that the genes whose expression levels were different between the two were 26 clones indicated in Table 3. These clones are involved in osteoporosis.
  • Genes Involved in Neural Cell Differentiation
  • Genes involved in neural cell differentiation are useful for treating neurological diseases. Genes with varying expression levels in response to induction of cellular differentiation in neural cells are thought to be involved in neurological diseases.
  • A survey was performed for genes whose expression levels are varied in response to induction of differentiation (stimulation by retinoic acid (RA) or growth inhibitor treatment after RA stimulation) in cultured cells of a neural strain, NT2. The result of comparative analysis of cDNA libraries derived from undifferentiated NT2 cells (NT2RM) and the cells subjected to the differentiation treatment (NT2RP, NT2RI or NT2NE) showed that the genes whose expression levels were different between the two were 193 clones indicated in Table 4. These genes are neurological disease-related genes.
  • Cancer-Related Genes
  • It has been assumed that, distinct from normal tissues, cancer tissues express a distinct set of genes, and thus the expression thereof can contribute to the carcinogenesis in tissues and cells. Thus, genes whose expression patterns in cancer tissues are different from those in normal tissues are cancer-related genes. Search was carried out for the genes whose expression levels in cancer tissues were different from those in normal tissues.
  • The result of comparative analysis of cDNA libraries derived from breast tumor (TBAES) and normal breast (BEAST) showed that the genes whose expression levels were different between the two were 4 clones indicated in Table 5.
  • The result of comparative analysis of cDNA libraries derived cervical tumor (TCERX) and normal cervical duct (CERVX) showed that the genes whose expression levels were different between the two was one clone indicated in Table 6.
  • The result of comparative analysis of cDNA libraries derived from colon tumor (TCOLN) and normal colon (COLON) showed that the genes whose expression levels were different between the two was one clone indicated in Table 7.
  • The result of comparative analysis of cDNA libraries derived from esophageal tumor (TESOP) and normal esophagus (NESOP) showed that the genes whose expression levels were different between the two were 6 clones indicated in Table 8.
  • The result of comparative analysis of cDNA libraries derived from kidney tumor (TKIDN) and normal kidney (KIDNE) showed that the genes whose expression levels were different between the two were 132 clones indicated in Table 9.
  • The result of comparative analysis of cDNA libraries derived from liver tumor (TLIVE) and normal liver (LIVER) showed that the genes whose expression levels were different between the two were 25 clones indicated in Table 10.
  • The result of comparative analysis of cDNA libraries derived from lung tumor (TLUNG) and normal lung (HLUNG) showed that the genes whose expression levels were different between the two were 99 clones indicated in Table 11.
  • The result of comparative analysis of cDNA libraries derived from ovary tumor (TOVER) and normal ovary (NOVER) showed the genes whose expression levels were different between the two were 3 clones indicated in Table 12.
  • The result of comparative analysis of cDNA libraries derived from stomach tumor (TSTOM) and normal stomach (STOMA) showed that the genes whose expression levels were different between the two were 15 clones indicated in Table 13.
  • The result of comparative analysis of cDNA libraries derived from uterine tumor (TUTER) and normal uterus (UTERU) showed that the genes whose expression levels were different between the two were 97 clones indicated in Table 14.
  • The result of comparative analysis of cDNA libraries derived from tongue cancer (CTONG) and normal tongue (NTONG) showed that the genes whose expression levels were different between the two were 203 clones indicated in Table 15.
  • These genes are involved in cancers.
  • Further, there is a method to search for genes involved in development and differentiation, which is the expression frequency analysis in which the expression levels of genes are compared between developing and/or differentiating tissues and/or cells and adult tissues and/or cells. The genes involved in tissue development and/or differentiation are genes participating in tissue construction and expression of function, and thus are useful genes, which are available for regenerative medicine aiming at convenient regeneration of injured tissues.
  • By using the information of gene expression frequency gained from the database of 5′-end nucleotide sequences described above, genes involved in development or differentiation of particular tissues were selected from the 1970 clones whose full-length nucleotide sequence had been revealed (see Example 7).
  • The result of comparative analysis of cDNA libraries derived from fetal brain (FCBBF, FEBRA or OCBBF) and adult brain (BRACE, BRALZ, BRAMY, BRAWH, BRCAN, BRCOC, BRHIP, BRSSN, BRSTN or BRTHA) showed that the genes whose expression levels were different between the two were 775 clones indicated in Tables 16 to 36.
  • The result of comparative analysis of cDNA libraries derived from fetal heart (FEHRT) and adult heart (HEART) showed that the genes whose expression levels were different between the two were 28 clones indicated in Table 37.
  • The result of comparative analysis of cDNA libraries derived from fetal kidney (FEKID) and adult kidney (KIDNE) showed that the genes whose expression levels were different between the two were 95 clones indicated in Table 38.
  • The result of comparative analysis of cDNA libraries derived from fetal lung (FELNG) and adult lung (HLUNG) showed that the genes whose expression levels were different between the two were 99 clones indicated in Table 39. These genes are involved in regeneration of tissues and/or cells.
  • The expression frequency or the like can be analyzed by PCR based on the nucleotide sequences of cDNAs of the present invention. There are some known methods for comparing the quantities of amplification products obtained by PCR. For example, the band intensities can be determined by ethidium bromide staining. With R1-labeled or fluorescently labeled primers, the R1 signal or fluorescence intensity can be assayed for the quantity of labeled amplification products. Alternatively, the quantity of amplification products can also be determined by measuring the RI signal or the fluorescence intensity from the RI-labeled or fluorescently labeled probe hybridizing to the products. The assay results thus obtained are compared and then the clones exhibiting differences in the expression levels can be selected.
  • There are some quantitative PCR methods: a PCR method using internal standards; a competitive PCR, in which the quantification is achieved by adding, to a sample, a dilution series of a known quantity of a template RNA and by comparing the quantity of an amplification product derived from the RNA of interest with the quantity of an amplification product derived from the template RNA. These methods overcome the problems of errors in the amount of amplification products among tubes and of the plateau effect. ATAC-PCR (Adaptor-tagged competitive PCR) is a method of competitive PCR which is practiced by using multiple adapters of different sizes attached to a gene whose 3′-end nucleotide sequence has previously been determined. The ratio of expression frequency of a single mRNA species from a number of tissues (cells) can be assayed in a single step (Nucleic Acids Research 1997, 25 (22): 4694-4696; “DNA Micro-array and Advanced PCR Techniques”, Cell Technology, supplement, Eds., Muramatsu and Nawa (Shujunsha, 2000): 104-112).
  • If it is observed, by using these analytical methods, that the expression levels of genes are evidently varied during major cellular events (such as differentiation and apoptosis), the genes are involved in the cellular events and accordingly are candidates for disease- and/or disorder-related genes. Further, genes exhibiting tissue-specific expression are genes playing important parts in the tissue functions and, therefore, can be candidates for genes involved in diseases and/or disorders affecting the tissues.
  • For example, inflammation is an important biological response that is known to be involved in various diseases. The representative inflammation-inducing factors include TNF-α (Tumor Necrosis Factor-alpha). There exists a signaling cascade activated by TNF-α stimulations, wherein NF-κB is a transducing molecule (Cell 1995, 80:529-532). It has also been revealed that many inflammation-related genes, including IL-2, IL-6 and G-CSF, are varied in the expression levels thereof in response to the signal through the pathway (Trends Genet. 1999, 15 (6): 229-235). It is assumed that genes whose expression levels are varied in response to the stimulation of TNF-α also participate in inflammation.
  • Further, the infection of Helicobacter pylori to the gastric epithelia is known to cause gastritis and gastroduodenal ulcer (Mebio 2000, July, 17 (7): 16-33). Thus, the genes whose expression levels are altered depending on co-culturing cells with Helicobacter pylori may be involved in gastritis and gastroduodenal ulcer. A recent study has suggested that Helicobacter pylori strongly activates the NF-κB pathway (Gastroenterology 2000, 119: 97-108).
  • THP-1 cell, which is a human monocyte cell line, was cultured in the presence of TNF-α (Tumor Necrosis Factor-alpha). The genes whose expression levels were altered owing to the presence of TNF-α were searched for, and the result showed that the clones whose expression levels were increased owing to the presence of TNF-α were
    ASTRO20055530, ASTRO20055930,
    ASTRO20088950, BRAMY20027390,
    BRAMY20076130, BRAMY20118410,
    BRAMY20125360, BRAMY20237190,
    BRCAN20001480, BRHIP10000720,
    CD34C20001750, CTONG20078340,
    CTONG20085210, DFNES20063460,
    FCBBF20029280, FCBBF20033360,
    FCBBF30078600, FEBRA20007820,
    FEBRA20031280, FEBRA20031810,
    FEBRA20040290, HLUNG20041540,
    HLUNG20092530, MESAN20021860,
    MESAN20067430, MESAN20084150,
    NT2NE20092950, NT2RP70031070,
    OCBBF20012520, OCBBF20142290,
    OCBBF20165900, OCBBF20170350,
    OCBBF20176650, PLACE60006300,
    PROST20011160, PROST20106060,
    SPLEN20040780, SPLEN20110860,
    SPLEN20177400, TESTI20030610,
    TESTI20043130, TESTI20059370,
    TESTI20254480, THYMU10004280,
    THYMU20030460, THYMU20062520,
    THYMU20078240, THYMU20150190,
    TRACH20090060, TRACH20125620,
    UTERU20026620, UTERU20045200,
    UTERU20064120, UTERU20103200.
  • On the other hand, the clones whose expression levels were decreased owing to the presence of TNF-α were
    BNGH420052350, BRACE20052530,
    BRAMY20003880, CTONG20170940,
    FCBBF30022680, FCBBF30225930,
    FCBBF30257370, FEBRA20046280,
    KIDNE20084030, KIDNE20188630,
    NT2NE20082130, OCBBF20110210,
    PLACE60061370, PROST20041460,
    PROST20075280, PROST20110120,
    SMINT20006020, TESTI20046540,
    TESTI20057200, TESTI20113940,
    TESTI20257910, TESTI20262940,
    TRACH20149740.
  • These clones are inflammation-related genes.
  • MKN45, which is a gastric cancer cell line, was co-cultured with Helicobacter pylori. The genes whose expression levels were altered owing to the presence of Helicobacter pylori were searched for, and the result showed that the clones whose expression levels were increased owing to the presence of Helicobacter pylori were
    BRAMY20028530, BRAMY20035380, OCBBF20170350,
    PROST20011160, SKMUS20091900, SPLEN20040780,
    THYMU20078240, TRACH20190460, UTERU20045200,
    UTERU20064120, ASTRO20055530, CTONG20170940,
    FEBRA20040290, MESAN20067430, PROST20016760,
    THYMU10004280, TRACH20090060, UTERU20041970,
    OCBBF20142290, TESTI20030610.
  • On the other hand, the clones whose expression levels were decreased owing to the presence of Helicobacter pylori were
    ASTRO20088950, BRACE20052530, BRAMY20003880,
    BRAMY20027390, BRAMY20036530, BRAMY20118410,
    BRHIP20000210, FCBBF20032930, FCBBF30022680,
    FCBBF30169870, FEBRA20182030, KIDNE20182540,
    LIVER20007750, MESAN20021220, NT2NE20059210,
    NT2NE20082130, OCBBF20155030, PROST20065100,
    PROST20075280, SPLEN20110860, TESTI20057200,
    TESTI20113940, TESTI20149880, TESTI20151800,
    TESTI20198600, TESTI20257910, THYMU20046770,
    THYMU20058550, THYMU20150190, FCBBF20033360,
    FCBBF30257370, FEBRA20098040, SMINT20006020.
  • These clones are involved in gastritis or gastroduodenal ulcer.
  • For example, if the polypeptide encoded by the cDNA of the present invention is a regulatory factor of cellular conditions such as growth and differentiation, it can be used for developing medicines as follows. The polypeptide or antibody provided by the invention is injected into a certain kind of cells by microinjection. Then, using the cells, it is possible to screen low molecular weight compounds, etc. by measuring the change in the cellular conditions, or the activation or inhibition of a particular gene. The screening can be performed as follows.
  • First, the polypeptide is expressed and purified as recombinant. The purified polypeptide is microinjected into cells such as various cell lines, or primary culture cells, and the cellular change such as growth and differentiation can be examined. Alternatively, the induction of genes whose expression is known to be involved in a particular change of cellular conditions may be detected by the amount of mRNA or polypeptide. Alternatively, the amount of intracellular molecules (low molecular weight compounds, etc.) that is changed by the function of the gene product (polypeptide) which is known to be involved in a particular change of cellular conditions may be detected.
  • The compounds to be screened (both low and high molecular compounds are acceptable) can be added to the culture media and assessed for their activity by measuring the change of the cellular conditions.
  • Instead of microinjection, cell lines introduced with the gene obtained in the invention can be used for the screening. If the gene product is turn out to be involved in a particular change in the cellular conditions, the change of the product can be used as a measurement for screening. Once a compound is screened out which can activate or inhibit the function of the polypeptide of the invention, it can be applied for developing medicines.
  • If the polypeptide encoded by the cDNA of the present invention is a secretory protein, membrane protein, or protein involved in signal transduction, glycoprotein, transcription, or diseases, it can be used in functional assays for developing medicines.
  • In case of a membrane protein, it is most likely to be a polypeptide that functions as a receptor or ligand on the cell surface. Therefore, it is possible to reveal a new relationship between a ligand and receptor by screening the membrane protein of the invention based on the binding activity with the known ligand or receptor. Screening can be performed according to the known methods.
  • For example, a ligand against the polypeptide of the invention can be screened in the following manner. Namely, a ligand that binds to a specific polypeptide can be screened by a method comprising the steps of: (a) contacting a test sample with the polypeptide of the invention or a partial peptide thereof, or cells expressing these, and (b) selecting a test sample that binds to said polypeptide, said partial peptide, or said cells.
  • On the other hand, for example, screening using cells expressing the polypeptide of the present invention that is a receptor protein can also be performed as follows. It is possible to screen receptors that is capable of binding to a specific polypeptide by using procedures (a) attaching the sample cells to the polypeptide of the invention or its partial peptide, and (b) selecting cells that can bind to the said polypeptide or its partial peptide.
  • In a following screening as an example, first the polypeptide of the invention is expressed, and the recombinant polypeptide is purified. Next, the purified polypeptide is labeled, binding assay is performed using a various cell lines or primary cultured cells, and cells that are expressing a receptor are selected (Growth and differentiation factors and their receptors, Shin-Seikagaku Jikken Kouza Vol. 7 (1991) Honjyo, Arai, Taniguchi, and Muramatsu edit, p203-236, Tokyo-Kagaku-Doujin). A polypeptide of the invention can be labeled with RI such as 125I, and enzyme (alkaline phosphatase etc.).
  • Alternatively, a polypeptide of the invention may be used without labeling and then detected by using a labeled antibody against the polypeptide. The cells that are selected by the above screening methods, which express a receptor of the polypeptide of the invention, can be used for the further screening of an agonists or antagonists of the said receptor.
  • Once the ligand binding to the polypeptide of the invention, the receptor of the polypeptide of the invention or the cells expressing the receptor are obtained by screening, it is possible to screen a compound that binds to the ligand and receptor. Also it is possible to screen a compound that can inhibit both bindings (agonists or antagonists of the receptor, for example) by utilizing the binding activities.
  • When the polypeptide of the invention is a receptor, the screening method comprises the steps of (a) contacting the polypeptide of the invention or cells expressing the polypeptide of the invention with the ligand, in the presence of a test sample, (b) detecting the binding activity between said polypeptide or cells expressing said polypeptide and the ligand, and (c) selecting a compound that reduces said binding activity when compared to the activity in the absence of the test sample. Furthermore, when the polypeptide of the invention is a ligand, the screening method comprises the steps of (a) contacting the polypeptide of the invention with its receptor or cells expressing the receptor in the presence of samples, (b) detecting the binding activity between the polypeptide and its receptor or the cells expressing the receptor, and (c) selecting a compound that can potentially reduce the binding activity compared to the activity in the absence of the sample.
  • Samples to screen include cell extracts, expressed products from a gene library, synthesized low molecular compound, synthesized peptide, and natural compounds, for example, but are not construed to be listed here. A compound that is isolated by the above screening using a binding activity of the polypeptide of the invention can also be used as a sample.
  • A compound isolated by the screening may be a candidate to be an agonist or an antagonist of the receptor of the polypeptide. By utilizing an assay that monitors a change in the intracellular signaling such as phosphorylation which results from reduction of the binding between the polypeptide and its receptor, it is possible to identify whether the obtained compound is an agonist or antagonist of the receptor. Also, the compound may be a candidate of a molecule that can inhibit the interaction between the polypeptide and its associated proteins (including a receptor) in vivo. Such compounds can be used for developing drugs for precaution or cures of a disease in which the polypeptide is involved.
  • Secretory proteins may regulate cellular conditions such as growth and differentiation. It is possible to find out a novel factor that regulates cellular conditions by adding the secretory protein of the invention to a certain kind of cell, and performing a screening by utilizing the cellular changes in growth or differentiation, or activation of a particular gene.
  • The screening can be performed, for example, as follows. First, the polypeptide of the invention is expressed and purified in a recombinant form. Then, the purified polypeptide is added to a various kind of cell lines or primary cultured cells, and the change in the cell growth and differentiation is monitored. The induction of a particular gene that is known to be involved in a certain cellular change is detected by the amounts of mRNA and polypeptide. Alternatively, the amount of an intracellular molecule (low-molecular-weight compounds, etc.) that is changed by the function of a gene product (polypeptide) that is known to function in a certain cellular change is used for the detection.
  • Once the screening reveals that the polypeptide of the invention can regulate cellular conditions or the functions, it is possible to apply the polypeptide as a pharmaceutical and diagnostic medicine for related diseases by itself or by altering a part of it into an appropriate composition.
  • As is above described for membrane proteins, the secretory protein provided by the invention may be used to explore a novel ligand-receptor interaction using a screening based on the binding activity to a known ligand or receptor. A similar method can be used to identify an agonist or antagonist. The resulting compounds obtained by the methods can be a candidate of a compound that can inhibit the interaction between the polypeptide of the invention and an interacting molecule (including a receptor). The compounds may be able to use as a preventive, therapeutic, and diagnostic medicine for the diseases, in which the polypeptide may play a certain role.
  • Proteins involved in signal transduction or transcription may be a factor that affects a certain polypeptide or gene in response to intracellular/extracellular stimuli. It is possible to find out a novel factor that can affect a polypeptide or gene by expressing the polypeptide provided by the invention in a certain types of cells, and performing a screening utilizing the activation of a certain intracellular polypeptide or gene.
  • The screening may be performed as follows. First, a transformed cell line expressing the polypeptide is obtained. Then, the transformed cell line and the untransformed original cell line are compared for the changes in the expression of a certain gene by detecting the amount of its mRNA or polypeptide. Alternatively, the amount of an intracellular molecule (low molecular weight compounds, etc.) that is changed by the function of a certain gene product (polypeptide) may be used for the detection. Furthermore, the change of the expression of a certain gene can be detected by introducing a fusion gene that comprises a regulatory region of the gene and a marker gene (luciferase, β-galactosidase, etc.) into a cell, expressing the polypeptide provided by the invention into the cell, and estimating the activity of a marker gene product (polypeptide).
  • If the polypeptide or gene of the invention is involved in diseases, it is possible to screen a gene or compound that can regulate its expression and/or activity either directly or indirectly by utilizing the polypeptide of the present invention.
  • For example, the polypeptide of the invention is expressed and purified as a recombinant polypeptide. Then, the polypeptide or gene that interacts with the polypeptide of the invention is purified, and screened based on the binding. Alternatively, the screening can be performed by adding with a compound of a candidate of the inhibitor added in advance and monitoring the change of binding activity. In another method, a transcription regulatory region locating in the 5′-upstream of the gene encoding the polypeptide of the invention that is capable of regulating the expression of other genes is obtained, and fused with a marker gene. The fusion is introduced into a cell, and the cell is added with compounds to explore a regulatory factor of the expression of the said gene.
  • The compound obtained by the screening can be used for developing pharmaceutical and diagnostic medicines for the diseases in which the polypeptide of the present invention is involved. Similarly, if the regulatory factor obtained in the screening is turn out to be a polypeptide, compounds that can newly affect the expression or activity of the polypeptide may be used as a medicine for the diseases in which the polypeptide of the invention is involved.
  • If the polypeptide of the invention has an enzymatic activity, regardless as to whether it is a secretory protein, membrane protein, or proteins involved in signal transduction, glycoprotein, transcription, or diseases, a screening may be performed by adding a compound to the polypeptide of the invention and monitoring the change of the compound. The enzymatic activity may also be utilized to screen a compound that can inhibit the activity of the polypeptide.
  • In a screening given as an example, the polypeptide of the invention is expressed and the recombinant polypeptide is purified. Then, compounds are contacted with the purified polypeptide, and the amount of the compound and the reaction products is examined. Alternatively, compounds that are candidates of an inhibitor are pretreated, then a compound (substrate) that can react with the purified polypeptide is added, and the amount of the substrate and the reaction products is examined.
  • The compounds obtained in the screening may be used as a medicine for diseases in which the polypeptide of the invention is involved. Also they can be applied for tests that examine whether the polypeptide of the invention functions normally in vivo.
  • Whether the secretory protein, membrane protein, signal transduction-related protein, glycoprotein-related protein, or transcription-related protein of the present invention is a novel protein involved in diseases or not is determined in another method than described above, by obtaining a specific antibody against the polypeptide of the invention, and examining the relationship between the expression or activity of the polypeptide and a certain disease. In an alternative way, it may be analyzed referred to the methods in “Molecular Diagnosis of Genetic Diseases” (Elles R. edit, (1996) in the series of “Method in Molecular Biology” (Humana Press).
  • Proteins involved in diseases are targets of screening as mentioned, and thus are very useful in developing drugs which regulate their expression and activity. Also, the proteins are useful in the medicinal industry as a diagnostic marker of the related disease or a target of gene therapy.
  • Compounds isolated as mentioned above can be administered patients as it is, or after formulated into a pharmaceutical composition according to the known methods. For example, a pharmaceutically acceptable carrier or vehicle, specifically sterilized water, saline, plant oil, emulsifier, or suspending agent can be mixed with the compounds appropriately. The pharmaceutical compositions can be administered to patients by a method known to those skilled in the art, such as intraarterial, intravenous, or subcutaneous injections. The dosage may vary depending on the weight or age of a patient, or the method of administration, but those skilled in the art can choose an appropriate dosage properly. If the compound is encoded by polynucleotide, the polynucleotide can be cloned into a vector for gene therapy, and used for gene therapy. The dosage of the polynucleotide and the method of its administration may vary depending on the weight or age of a patient, or the symptoms, but those skilled in the art can choose properly.
  • The present invention further relates to databases comprising at least a sequence of polynucleotide and/or polypeptide, or a medium recorded in such databases, selected from the sequence data of the nucleotide and/or the amino acids indicated in Table 1. The term “database” means a set of accumulated information as machine-searchable and readable information of nucleotide sequence. The databases of the present invention comprise at least one of the novel nucleotide sequences of polynucleotides provided by the present invention. The databases of the present invention can consist of only the sequence data of the novel polynucleotides provided by the present invention or can comprise other information on nucleotide sequences of known full-length cDNAs or ESTs. The databases of the present invention can be comprised of not only the information on the nucleotide sequences but also the information on the gene functions revealed by the present invention. Additional information such as names of DNA clones carrying the full-length cDNAs can be recorded or linked together with the sequence data in the databases.
  • The database of the present invention is useful for gaining complete gene sequence information from partial sequence information of a gene of interest. The database of the present invention comprises nucleotide sequence information of full-length cDNAs. Consequently, by comparing the information in this database with the nucleotide sequence of a partial gene fragment yielded by differential display method or subtraction method, the information on the full-length nucleotide sequence of interest can be gained from the sequence of the partial fragment as a starting clue.
  • The sequence information of the full-length cDNAs constituting the database of the present invention contains not only the information on the complete sequences but also extra information on expression frequency of the genes as well as homology of the genes to known genes and known polypeptides. Thus the extra information facilitates rapid functional analyses of partial gene fragments. Further, the information on human genes is accumulated in the database of the present invention, and therefore, the database is useful for isolating a human homologue of a gene originating from other species. The human homologue can be isolated based on the nucleotide sequence of the gene from the original species.
  • At present, information on a wide variety of gene fragments can be obtained by differential display method and subtraction method. In general, these gene fragments are utilized as tools for isolating the full-length sequences thereof. When the gene fragment corresponds to an already-known gene, the full-length sequence is easily obtained by comparing the partial sequence with the information in known databases. However, when there exists no information corresponding to the partial sequence of interest in the known databases, cDNA cloning should be carried out for the full-length cDNA. It is often difficult to obtain the full-length nucleotide sequence using the partial sequence information as an initial clue. If the full-length of the gene is not available, the amino acid sequence of the polypeptide encoded by the gene remains unidentified. Thus the database of the present invention can contribute to the identification of full-length cDNAs corresponding to gene fragments, which cannot be revealed by using databases of known genes.
  • The present invention has provided 1970 polynucleotides. As has not yet proceeded the isolation of full-length cDNA within the human, the invention has great significance. It is known that secretory proteins, membrane proteins, signal transduction-related proteins, glycoprotein-related proteins, transcription-related proteins, and so on are involved in many diseases. The genes and proteins involved in diseases are useful for developing a diagnostic marker or medicines for regulation of their expression and activity, or as a target of gene therapy.
  • In particular, cDNA assumed to encode secretory proteins, which were provided by this invention, are very important for the industry since the encoded proteins themselves are expected to be useful as pharmaceutical agents and many disease-related genes may be included in them. In addition, membrane proteins, signal transduction-related proteins, transcription-related proteins, disease-related proteins, and genes encoding them can be used as indicators for diseases, etc. These cDNA are also very important for the industry, which are expected to regulate the activity or expression of the encoded protein to treat diseases, etc.
  • Any patents, patent applications, and publications cited herein are incorporated by reference.
  • The invention is illustrated more specifically with reference to the following examples, but is not to be construed as being limited thereto.
    • EXAMPLE 1 Preparation of cDNA Library by Oligo-Capping
  • (1) Extraction and Purchase of mRNA
  • Total RNAs as mRNA sources were extracted from human tissues (shown below) by the method as described in the reference (J. Sambrook, E. F. Fritsch & T. Maniatis, Molecular Cloning Second edition, Cold Spring harbor Laboratory Press, 1989). Further, by the method as described in the reference (J. Sambrook, E. F. Fritsch & T. Maniatis, Molecular Cloning Second edition, Cold Spring harbor Laboratory Press, 1989), total RNAs as mRNA sources were extracted from human culture cells and human primary culture cells (shown below) which had been cultivated by the methods described in the catalogs.
  • The library names and the origins are indicated below in the order of “Library name: Origin”. When a library was prepared by the subtraction method, the item is followed by a description of how to prepare the subtracted library.
  • <Extraction of mRNA from Human Tissues>
    • NTONG: Normal tongue;
    • CTONG: Tongue cancer;
    • FCBBF: Fetal brain;
    • OCBBF: Fetal brain;
    • PLACE: Placenta;
    • SYNOV: Synovial membrane tissue (from rheumatioid arthritis).
      <Extraction of mRNA from Culture Cells>
    • BNGH4: H4 cells (ATCC #HTB-148);
    • IMR32: IMR32 cells (ATCC #CCL-127);
    • SKNMC: SK-N-MC cells (ATCC #HTB-10);
    • 3NB69: NB69 cells (RCB #RCB0480);
    • BGGI1: GI1 cells (RCB #RCB0763);
    • NB9N4: NB9 cells (RCB #RCB0477);
    • SKNSH: SK-N-SH cells (RCB #RCB0426);
    • NT2RM: NT2 cells (STARATAGENE #204101);
    • NT2RP: NT2 cells treated with retinoic acid (RA) for 5 weeks to induce the differentiation;
    • NT2R1: NT2 cells treated with RA for 5 weeks to induce the differentiation, followed by the treatment with the growth inhibitor for 2 weeks;
    • NT2NE: NT2 cells were treated with RA and the growth inhibitor for the neuronal differentiation, and the resultant neurons were concentrated and harvested (NT2 Neuron);
    • NTISM: NT2 cells (STARATAGENE #204101) were treated with RA for 5 weeks to induce the differentiation, and then treated with the growth inhibitor for 2 weeks; mRNA was prepared from the cells and a cDNA library was constructed from the mRNA; the cDNAs of the library whose nucleotide sequences were shared by those of mRNAs from undifferentiated NT2 cells were subtracted by using a Subtract Kit (Invitrogen #K4320-01); the subtracted library (NT2R1-NT2RM) was provided by this procedure.
  • RCB indicates that the cell was provided by the Cell Bank, RIKEN GENE BANK, The Institute of Physical and Chemical Research; ATCC indicates that the cell was provided by American Type Culture Collection.
  • <Extraction of mRNA from Primary Culture Cells>
    • ASTRO: Normal human astrocyte NHA5732, Takara Shuzo #CC2565;
    • DFNES: Normal human dermal fibroblast (neonatal skin); NHDF-Neo NHDF2564, Takara Shuzo #CC2509;
    • MESAN: Normal human mesangial cell NHMC56046-2, Takara Shuzo #CC2559;
    • NHNPC: Normal human neural progenitor cell NHNP5958, Takara Shuzo #CC2599;
    • PEBLM: Normal human peripheral blood mononuclear cell HPBMC5939, Takara Shuzo #CC2702;
    • HSYRA: Human synoviocyte HS-RA (from rheumatioid arthritis), Toyobo #T404K-05;
    • PUAEN: Normal human pulmonary artery endothelial cells, Toyobo #T302K-05;
    • UMVEN: Normal human umbilical vein endothelial cell HUVEC, Toyobo #T200K-05;
    • HCASM: Normal human coronary artery smooth muscle cell HCASMC, Toyobo #T305K-05;
    • HCHON: Normal human chondrocyte HC, Toyobo #T402K-05;
    • HHDPC: Normal human dermal papilla cell HDPC, Toyobo #THPCK-001;
    • CD34C: CD34+ cells (AllCells, LLC #CB14435M);
    • D30ST: CD34+ cells treated with the osteoclast differentiation factor (ODF) for 3 days to induce the differentiation;
    • D60ST: CD34+ cells treated with ODF for 6 days to induce the differentiation;
    • D90ST: CD34+ cells treated with ODF for 9 days to induce the differentiation.
  • Then, total RNAs extracted from the following human tissues were purchased and used as mRNA sources. The library names and the origins are indicated below in the order of “Library name: Origin”. When a library was prepared by the subtraction method, the item is followed by a description of how to prepare the subtracted library.
  • <Purchase of Total RNA Containing mRNA Extracted from Human Tissues>
    • ADRGL: Adrenal gland, CLONTECH #64016-1;
    • BRACE: Brain (cerebellum), CLONTECH #64035-1;
    • BRAWH: Whole brain, CLONTECH #64020-1;
    • FEBRA: Fetal brain, CLONTECH #64019-1;
    • FELIV: Fetal liver, CLONTECH #64018-1;
    • HEART: Heart, CLONTECH #64025-1;
    • HLUNG: Lung, CLONTECH #64023-1;
    • KIDNE: Kidney, CLONTECH #64030-1;
    • LIVER: Liver, CLONTECH #64022-1;
    • MAMGL: Mammary Gland, CLONTECH #64037-1;
    • PANCR: Pancreas, CLONTECH #64031-1;
    • PROST: Prostate, CLONTECH #64038-1;
    • SALGL: Salivary Gland, CLONTECH #64026-1;
    • SKMUS: Skeletal Muscle, CLONTECH #64033-1;
    • SMINT: Small Intestine, CLONTECH #64039-1;
    • SPLEN: Spleen, CLONTECH #64034-1;
    • STOMA: Stomach, CLONTECH #64090-1;
    • TBAES: Breast (Tumor), CLONTECH #64015-1;
    • TCERX: Cervix (Tumor), CLONTECH #64010-1;
    • TCOLN: Colon (Tumor), CLONTECH #64014-1;
    • TESTI: Testis, CLONTECH #64027-1;
    • THYMU: Thymus, CLONTECH #64028-1;
    • TLUNG: Lung (Tumor), CLONTECH #64013-1;
    • TOVAR: Ovary (Tumor), CLONTECH #64011-1;
    • TRACH: Trachea, CLONTECH #64091-1;
    • TUTER: Uterus (Tumor), CLONTECH #64008-1;
    • UTERU: Uterus, CLONTECH #64029-1;
    • ADIPS: Adipose, Invitrogen #D6005-01;
    • BLADE: Bladder, Invitrogen #D6020-01;
    • BRALZ: Cerebral cortex from an Alzheimer patient (Brain, cortex, Alzheimer), Invitrogen #D6830-01;
    • CERVX: Cervix, Invitrogen #D6047-01;
    • COLON: Colon, Invitrogen #D6050-0;
    • NESOP: Esophagus, Invitrogen #D6060-01;
    • PERIC: Pericardium, Invitrogen #D6105-01;
    • RECTM: Rectum, Invitrogen #D6110-01;
    • TESOP: Esophageal (Tumor), Invitrogen #D6860-01;
    • TKIDN: Kidney (Tumor), Invitrogen #D6870-01;
    • TLIVE: Liver (Tumor), Invitrogen #D6880-01;
    • TSTOM: Stomach (Tumor), Invitrogen #D6920-01;
    • BEAST: Adult breast, STARATAGENE #735044;
    • FEHRT: Fetal heart, STARATAGENE #738012;
    • FEKID: Fetal kidney, STARATAGENE #738014;
    • FELNG: Fetal lung, STARATAGENE #738020;
    • NOVAR: Adult ovary, STARATAGENE #735260;
    • BRASW: subtracted library (BRALZ-BRAWH). A cDNA library was constructed from mRNA prepared from tissues of cerebral cortex obtained from an Alzheimer patient [BRALZ: Cerebral cortex from an Alzheimer patient (Brain, cortex, Alzheimer), Invitrogen #D6830-01]; the cDNAs of this library whose nucleotide sequences were shared by those of mRNAs from whole brain tissue [BRAWH: Whole brain, CLONTECH #64020-1] were subtracted by using a Subtract Kit (Invitrogen #K4320-01).
  • Further, mRNAs extracted and purified as poly A(+) RNAs from the human tissues shown below were purchased. A cDNA library was prepared from an RNA mixture in which the poly A(+) RNA from each tissue had been combined with poly A(−) RNA. The poly A(−) RNA was prepared by removing poly A(+) RNA from the total RNA of whole brain tissue (CLONTECH #64020-1) by using oligo dT cellulose. The library names and the origins are indicated below in the order of “Library name: Origin”.
  • <Purchase of mRNAs of Human Tissues as Poly A(+) RNAs>
    • BRAMY: Brain (amygdala), CLONTECH #6574-1;
    • BRCAN: Brain (caudate nucleus), CLONTECH #6575-1;
    • BRCOC: Brain (corpus callosum), CLONTECH #6577-1;
    • BRHIP: Brain (hippocampus), CLONTECH #6578-1;
    • BRSSN: Brain (substantia nigra), CLONTECH #6580-1;
    • BRSTN: Brain (subthalamic nucleus), CLONTECH #6581-1;
    • BRTHA: Brain (thalamus), CLONTECH #6582-1.
      (2) Preparation of cDNA Library
  • cDNA library was prepared from each RNA by the improved method (WO 01/04286) of oligo capping [M. Maruyama and S. Sugano, Gene, 138: 171-174 (1994)]. A series of procedures, BAP (Bacterial Alkaline Phosphatase) treatment, TAP (Tobacco Acid Pyrophosphatase) treatment, RNA ligation, first strand cDNA synthesis and RNA removal, were carried out using the oligo-cap linker (SEQ ID NO: 4093) and oligo dT primer (SEQ ID NO: 4094), as described in WO 01/04286. Then, the single-stranded cDNA was converted to a double-stranded cDNA by PCR (polymerase chain reaction) using 5′ (SEQ ID NO: 4095) and 3′ (SEQ ID NO: 4096) PCR primers, and then digested with SfiI. Then, a fraction of cDNA fragments, typically 2-kb or longer (3-kb or longer in some cases), was unidirectionally cloned into a DraIII-digested pME18SFL3 vector (FIG. 1) (GenBank AB009864, Expression vector); the cDNA library was thus prepared.
  • The names of cDNA libraries, which were used in the analysis of full-length cDNA sequences, and their origins are shown in Table 2.
    TABLE 2
    Library Type Origin, etc.
    ADRGL Tissue Adrenal gland (CLONTECH #64016-1)
    ASTRO Primary Normal Human Astrocyte NHA5732 (Takara Shuzo #CC2565)
    culture cell
    BGGI1 Culture cell GI1 cells (RCB #RCB0763)
    BNGH4 Culture cell H4 cells (ATCC #HTB-148)
    BRACE Tissue Brain, cerebellum (CLONTECH #64035-1)
    BRAMY Tissue Brain, amygdala (CLONTECH #6574-1)
    BRAWH Tissue Brain, whole (CLONTECH #64020-1)
    BRCAN Tissue Brain, caudate nucleus (CLONTECH #6575-1)
    BRCOC Tissue Brain, corpus callosum (CLONTECH #6577-1)
    BRHIP Tissue Brain, hippocampus (CLONTECH #6578-1)
    BRSSN Tissue Brain, substantia nigra (CLONTECH #6580-1)
    CD34C Primary CD34+ cells (AllCells, LLC #CB14435M)
    culture cell
    CTONG Tissue Tongue, Cancer
    DFNES Primary Normal Human Dermal Fibroblasts (Neonatal Skin): NHDF-Neo
    culture cell NHDF2564 (Takara Shuzo #CC2509)
    FCBBF Tissue Brain, Fetal
    FEBRA Tissue Brain, Fetal (CLONTECH #64019-1)
    HCHON Primary Human Chondrocytes HC (Toyobo #T402K-05)
    culture cell
    HEART Tissue Heart (CLONTECH #64025-1)
    HHDPC Primary Human dermal papilla cells HDPC (Toyobo #THPCK-001)
    culture cell
    HLUNG Tissue Lung (CLONTECH #64023-1)
    KIDNE Tissue Kidney (CLONTECH #64030-1)
    LIVER Tissue Liver (CLONTECH #64022-1)
    MESAN Primary Normal human mesangial cells NHMC56046-2 (Takara Shuzo
    culture cell #CC2559)
    NESOP Tissue Esophagus (Invitrogen #D6060-01)
    NT2NE Culture cell NT2 cells concentrated after differentiation (NT2 Neuron)
    NT2RI Culture cell NT2 cells treated by growth inhibitor for 2 weeks after RA
    induction for 5 weeks
    NT2RP Culture cell NT2 cells treated by RA for 5 weeks
    NTONG Tissue Tongue
    OCBBF Tissue Brain, Fetal
    PANCR Tissue Pancreas (CLONTECH #64031-1)
    PEBLM Primary Human peripheral blood mononuclear cells HPBMC5939
    culture cell (Takara Shuzo #CC2102)
    PLACE Tissue Placenta
    PROST Tissue Prostate (CLONTECH #64038-1)
    PUAEN Primary Human pulmonary artery endothelial cells (Toyobo #T302K-05)
    culture cell
    SALGL Tissue Salivary Gland (CLONTECH #64026-1)
    SKMUS Tissue Skeletal Muscle (CLONTECH #64033-1)
    SKNMC Culture cell SK-N-MC cells (ATCC #HTB-10)
    SKNSH Culture cell SK-N-SH cells (RCB #RCB0426)
    SMINT Tissue Small Intestine (CLONTECH #64039-1)
    SPLEN Tissue Spleen (CLONTECH #64034-1)
    TESOP Tissue Esophageal, Tumor (Invitrogen #D6860-01)
    TESTI Tissue Testis (CLONTECH #64027-1)
    THYMU Tissue Thymus (CLONTECH #64028-1)
    TKIDN Tissue Kidney, Tumor (Invitrogen #D6870-01)
    TRACH Tissue Trachea (CLONTECH #64091-1)
    UMVEN Primary Human umbilical vein endothelial cells HUVEC (Toyobo
    culture cell #T200K-05)
    UTERU Tissue Uterus (CLONTECH #64029-1)
  • The cDNA library with the high fullness ratio (the fullness ratio of 5′-end, which was calculated for each cDNA library by using the protein coding region found in known mRNA species as an index, was 90% in average) prepared by the improved oligo-capping method was constructed by using a eukaryotic expression vector pME18SFL3. The vector contains SRα promoter and SV40 small t intron in the upstream of the cloning site, and SV40 polyA added signal sequence site in the downstream. As the cloning site of pME18SFL3 has asymmetrical DraIII sites, and the ends of cDNA fragments contain SfiI sites complementary to the DraIII sites, the cloned cDNA fragments can be inserted into the downstream of the SRα promoter unidirectionally. Therefore, clones containing full-length cDNA can be expressed transiently by introducing the obtained plasmid directly into COS cells, etc. Thus, the clones can be analyzed very easily in terms of the proteins that are the gene products of the clones, or in terms of the biological activities of the proteins.
  • (3) Assessment of the 5′-end Completeness of Clones Derived from the cDNA Library Prepared by Oligo-Capping
  • With respect to the plasmid DNAs of clones derived from the libraries, the nucleotide sequences of cDNA 5′-ends (3′-ends as well in some cases) were determined in a DNA sequencer (ABI PRISM 3700, PE Biosystems), after sequencing reaction was conducted by using a DNA sequencing reagent (BigDye Terminator Cycle Sequencing FS Ready Reaction Kit, PE Biosystems) according to the manual. A database was constructed based on the obtained data.
  • The 5′-end completeness of about 770,000 clones derived from the human cDNA libraries prepared by the improved oligo-capping method was determined by the following method. The clones whose 5′-end sequences were consistent with those of known human mRNA in the public database were judged to be “full-length” if they had a longer 5′-end sequence than that of the known human mRNA; or even though the 5′-end sequence was shorter, if it contained the translation initiation codon it was judged to have the “full-length” sequence. Clones which did not contain the translation initiation codon were judged to be “not-full-length”. The fullness ratio ((the number of full-length clones)/(the number of full-length and not-full-length clones)) at the 5′-end of the cDNA clones was determined by comparing with known human mRNA. As a result, the fullness ratio of the 5′-ends was 90%. The result indicates that the fullness ratio at the 5′-end sequence was extremely high in the human cDNA clones obtained by the oligo-capping method.
    • EXAMPLE 2 Sequencing Analysis of cDNA Ends and Selection of Full-Length Clones
  • With respect to the plasmid DNAs of clones obtained from each cDNA library, the 5′-end nucleotide sequences of the cDNAs were determined in a DNA sequencer (ABI PRISM 3700, PE Biosystems), after sequencing reaction was conducted by using a DNA sequencing reagent (Dye Terminator Cycle Sequencing FS Ready Reaction Kit, dRhodamine Terminator Cycle Sequencing FS Ready Reaction Kit or BigDye Terminator Cycle Sequencing FS Ready Reaction Kit, PE Biosystems) according to the manual. A database was constructed using the data obtained.
  • For the analyzed 5′-end sequences of cDNA clones, the data with the annotation of “complete cds” in the GenBank and UniGene were searched by BLAST homology search. When identical to certain human mRNA sequences, such cDNA clones were excluded. Then, clustering was carried out. When the identity was 90% or higher, and the length of consensus sequence was 50 base pairs or longer, the cDNA clones were assumed to belong to an identical cluster, and thus clustered. cDNA clones longer in the 5′ direction were selected from the members belonging to a cluster; if required, the 31-end sequences of the selected clones were determined by the same analysis method as used to determine the 5′-end sequences. The data of the end sequences obtained were analyzed, and then the clones forming a sequence contig at 5′- and 3′-ends were excluded. Further, as mentioned above, the data was analyzed again by BLAST homology search; when identical to certain human mRNA sequences (including sequences patented and applied for), the cDNA clones were excluded. Thus, the cDNAs clones to be analyzed for their nucleotide sequence were obtained.
    • EXAMPLE 3 Analysis of the Full-Length Nucleotide Sequences
  • The full-length nucleotide sequences of the selected clones were determined. The nucleotide sequence determination was mainly performed by primer walking method comprising the dideoxy terminator method using custom-made synthetic DNA primers. Namely, the nucleotide sequences of the DNAs were determined in a sequencer from PE Biosystems, after sequencing reaction was carried out with a DNA sequencing reagent from the same supplier using the custom-made synthetic DNA primers according to the manual. A part of the clones were analyzed with a DNA sequencer from Licor.
  • Further, the nucleotide sequences of a part of the clones were determined by the shotgun method where the plasmids containing the cDNAs were digested at random were used, instead of the use of custom-made primers, by the same method in the DNA sequencer. The full-length nucleotide sequences were finally determined by completely assembling the partial nucleotide sequences obtained by the above method.
  • Then, the regions translatable to proteins were deduced from the determined full-length nucleotide sequences, and thereby the amino acid sequences were determined. SEQ ID NOs corresponding to the respective sequences are shown in Table 1.
    • EXAMPLE 4 Functional Prediction by Homology Search
  • For the determined nucleotide sequences, GenBank, SwissProt, UniGene, and nr were searched by BLAST. The clones exhibiting higher homology, which were convenient to predict their functions based on the nucleotide sequences and deduced amino acid sequences, were selected based on the BLAST search hit data whose P value or E value was 10−4 or lower and for which the length of consensus sequence×homology=30 or higher in the amino acid database search. Further, from them, representative clones were selected, which are shown as Homology Search Result Data in the last part herein. Accordingly, the data shown herein are merely the representative data, and the molecule exhibiting homology to each clone is not limited thereto. Further, with respect to a part of clones, the BLAST search hit data that did not meet the criteria as described above are not shown herein.
    • EXAMPLE 5 Search for Signal Sequence, Transmembrane Domain and Other Functional Domains in the Deduced Amino Acid Sequences
  • With respect to the amino acid sequences deduced from the full-length nucleotide sequences, the prediction was made for the presence of signal sequence at the amino terminus, the presence of transmembrane domain, and the presence of functional protein domains (motifs). The signal sequence at the amino terminus was searched for by PSORT [K. Nakai & M. Kanehisa, Genomics, 14: 897-911 (1992)]; the transmembrane domain, by SOSUI [T. Hirokawa et al., Bioinformatics, 14: 378-379 (1998)] (Mitsui Knowledge Industry); the function domain, by Pfam (http://www.sanger.ac.uk/Software/Pfam/index.shtml). The amino acid sequence in which the signal sequence at the amino terminus or transmembrane domain had been predicted to be present by PSORT or SOSUI were assumed to be a secretory or membrane protein. Further, when the amino acid sequence hit a certain functional domain by the Pfam functional domain search, the protein function can be predicted based on the hit data, for example, by referring to the function categories on the PROSITE (http://www.expasy.ch/cgi-bin/prosite-list.pl). In addition, the functional domain search can also be carried out on the PROSITE.
  • The search results obtained with the respective programs are shown below.
  • The clones whose deduced amino acid sequences were detected to have the signal sequences by PSORT are as follows.
    ADRGL20021910, ADRGL20036380, ADRGL20063770, ASTRO20020240,
    BNGH420052350, BNGH420077980, BRACE20054080, BRACE20194670,
    BRAMY20044920, BRAMY20047560, BRAMY20137360, BRAMY20204270,
    BRAMY20237190, BRAMY20251750, BRAWH20020470, BRAWH20093070,
    BRCAN10001680, BRHIP10000720, BRSSN20091190, CD34C20001750,
    CTONG20059130, CTONG20069320, FCBBF30062490, FCBBF30132660,
    FEBRA20039260, FEBRA20040230, FEBRA20040560, FEBRA20046280,
    FEBRA20182030, HCHON10001660, HCHON20015050, HEART10001490,
    HHDPC20088160, HLUNG20032460, HLUNG20034970, HLUNG20050760,
    HLUNG20081390, HLUNG20088750, KIDNE20134130, KIDNE20143200,
    LIVER20007750, LIVER20010510, MESAN20021220, MESAN20027900,
    MESAN20095220, NT2NE20069580, NT2NE20082130, NT2NE20167660,
    NT2RP70003110, OCBBF20000740, OCBBF20012520, OCBBF20110730, OCBBF20118720,
    OCBBF20155030, OCBBF20170350, OCBBF20191950,
    PANCR10000860, PEBLM20001800, PLACE60004260, PLACE60006300,
    PLACE60055590, PLACE60056910, PLACE60057860, PLACE60104630,
    PLACE60184870, PROST20050390, PROST20084680, PROST20105450,
    PROST20106060, PR0ST20110120, SKMUS20091900, SKNMC20006350,
    SMINT20024140, SMINT20028840, SMINT20086250, SMINT20088440,
    SMINT20088690, SPLEN20017810, SPLEN20073880, SPLEN20080070,
    SPLEN20101950, SPLEN20108000, SPLEN20110860, SPLEN20118050,
    SPLEN20138600, SPLEN20139100, SPLEN20193230, SPLEN20193490,
    SPLEN20201830, TESTI20043130, TESTI20047370, TESTI20057200, TESTI20059080,
    TESTI20061200, TESTI20063330, TESTI20063600, TESTI20102390, TESTI20116120,
    TESTI20151800, TESTI20166670, TESTI20210030, TESTI20245860, THYMU20020800,
    THYMU20046770, THYMU20050010, THYMU20054800, THYMU20055740,
    THYMU20083390, THYMU20115380, TRACH20081270, TRACH20159390,
    UTERU20040150, UTERU20064120, UTERU20086530, UTERU20127150
  • The clones whose deduced amino acid sequences were detected to have the transmembrane domains by SOSUI are as follows. Numerals indicate the numbers of transmembrane domains detected in the deduced amino acid sequences. Of the search result, the clone name and the number of transmembrane domains are demarcated by a double slash mark (//).
    ADRGL20020290//10, ADRGL20021910//2, ADRGL20063770//2,
    ASTRO20010010//4, ASTRO20045840//3, ASTRO20053430//1,
    ASTRO20055530//1, ASTRO20055570//2, ASTRO20055930//2,
    ASTRO20075150//1, ASTRO20088950//1, ASTRO20091180//4,
    BNGH420021680//1, BNGH420023870//1, BNGH420052350//1,
    BNGH420059680//1, BNGH420075940//1, BNGH420087430//3,
    BRACE10000510//2, BRACE20052530//1,
    BRACE20066360//3, BRACE20068710//1, BRACE20069000//5,
    BRACE20069110//1, BRAMY10001730//1, BRAMY20001510//1,
    BRAMY20003880//1, BRAMY20024790//2, BRAMY20027390//2,
    BRAMY20028530//2, BRAMY20035380//2, BRAMY20045210//1,
    BRAMY20050940//3, BRAMY20053910//2, BRAMY20055760//5,
    BRAMY20072440//8, BRAMY20083820//2, BRAMY20089770//1,
    BRAMY20096930//1, BRAMY20118410//1,
    BRAMY20123400//2, BRAMY20125550//1, BRAMY20127310//1,
    BRAMY20127760//1, BRAMY20135720//3, BRAMY20139440//5,
    BRAMY20152510//1, BRAMY20194680//2, BRAMY20204270//1,
    BRAMY20225320//2, BRAMY20237190//1, BRAMY20251750//1,
    BRAMY20285650//2, BRAWH20020470//7, BRAWH20026010//1,
    BRAWH20030000//2, BRAWH20039640//2, BRAWH20055330//1,
    BRAWH20078620//2, BRAWH20093040//3,
    BRAWH20185270//5, BRAWH20190550//1, BRCAN10000760//10,
    BRCAN20001480//3, BRCAN20004180//1, BRCOC20000470//2,
    BRCOC20003600//1, BRHIP10001040//5, BRHIP20000210//1,
    BRSSN20001970//4, BRSSN20074640//2, CD34C20001750//1,
    CTONG20017490//1, CTONG20029030//4, CTONG20041260//9,
    CTONG20044870//2, CTONG20045500//2, CTONG20049480//3,
    CTONG20051450//1, CTONG20056150//2,
    CTONG20059130//6, CTONG20060040//1, CTONG20065680//1,
    CTONG20071680//13, CTONG20076810//1, CTONG20078340//2,
    CTONG20079590//1, CTONG20083980//1, CTONG20084020//2,
    CTONG20167750//1, CTONG20168240//3, CTONG20179890//5,
    CTONG20183830//1, DFNES20018000//2, DFNES20028170//1,
    DFNES20029660//8, DFNES20072990//9, DFNES20080880//1,
    FCBBF20018680//3, FCBBF20029280//2,
    FCBBF20032930//1, FCBBF20036360//2, FCBBF20054390//2,
    FCBBF30022680//1, FCBBF30042610//7, FCBBF30062490//2,
    FCBBF30075970//1, FCBBF30078600//3, FCBBF30095410//1,
    FCBBF30105440//3, FCBBF30118670//1, FCBBF30145670//1,
    FCBBF30164510//1, FCBBF30169870//1, FCBBF30172330//1,
    FCBBF30177290//2, FCBBF30179740//1, FCBBF30195690//2,
    FCBBF30197840//1, FCBBF30212210//1,
    FCBBF30223110//1, FCBBF30225930//9, FCBBF30230610//1,
    FCBBF30260480//5, FCBBF30266510//3, FCBBF30287940//1,
    FCBBF50000610//2, FCBBF50004950//3, FEBRA20007820//4,
    FEBRA20018670//2, FEBRA20031280//7, FEBRA20031810//2,
    FEBRA20040560//4, FEBRA20057010//1, FEBRA20080860//1,
    FEBRA20084750//1, FEBRA20115930//10, FEBRA20116650//4,
    FEBRA20121950//5, FEBRA20141980//1,
    FEBRA20177800//1, FEBRA20182030//1, HCHON20015050//1,
    HEART20031680//1, HHDPC10001140//1, HHDPC20051850//1,
    HHDPC20082790//3, HHDPC20088160//1, HLUNG20015070//2,
    HLUNG20020850//2, HLUNG20029490//1, HLUNG20032460//1,
    HLUNG20033350//2, HLUNG20037160//2, HLUNG20050760//1,
    HLUNG20052300//1, HLUNG20060670//1, HLUNG20065990//1,
    HLUNG20074330//1, HLUNG20081390//2,
    HLUNG20092530//1, KIDNE20016360//5, KIDNE20083150//3,
    KIDNE20084030//12, KIDNE20084800//2, KIDNE20086490//1,
    KIDNE20086660//2, KIDNE20094670//1, KIDNE20142900//1,
    KIDNE20148080//1, KIDNE20160960//2, KIDNE20163710//1,
    KIDNE20169180//2, KIDNE20182540//3, KIDNE20186170//1,
    KIDNE20188630//1, KIDNE20189960//1, LIVER20007750//8,
    LIVER20010990//4, LIVER20030650//6,
    LIVER20038000//4, MESAN20007110//1, MESAN20008150//3,
    MESAN20021220//2, MESAN20060430//1, MESAN20067430//3,
    MESAN20084150//3, NT2NE20018740//1, NT2NE20039210//1,
    NT2NE20053230//1, NT2NE20059210//1, NT2NE20080770//1,
    NT2NE20082130//3, NT2NE20092950//1, NT2NE20152620//1,
    NT2NE20167660//1, NT2NE20181800//1, NT2RI20016240//2,
    NT2RI20021200//3, NT2RI20033920//5,
    NT2RP70027790//2, NT2RP70031070//10, NT2RP70031480//6,
    NT2RP70087140//1, OCBBF20000740//2, OCBBF20012520//2,
    OCBBF20109780//1, OCBBF20110210//2, OCBBF20110730//2,
    OCBBF20112280//3, OCBBF20118720//3, OCBBF20123200//2,
    OCBBF20165910//9, OCBBF20176650//1, OCBBF20185630//1,
    OCBBF20191950//3, PANCR10000860//1, PLACE60004260//1,
    PLACE60006300//2, PLACE60053280//3,
    PLACE60056910//1, PLACE60057860//3, PLACE60061370//1,
    PLACE60070500//2, PLACE60104630//3, PLACE60107010//2,
    PLACE60184870//1, PROST20011160//2, PROST20014150//2,
    PROST20035830//1, PROST20050390//1, PROST20065100//7,
    PROST20073280//1, PROST20082430//1, PROST20084680//3,
    PROST20105450//6, PROST20110120//1, PROST20114100//2,
    PROST20152510//4, PROST20168600//6,
    PUAEN10000870//2, SKMUS20006790//1, SKMUS20020770//1,
    SKNMC20006350//1, SKNSH20094350//2, SMINT20008110//3,
    SMINT20024140//1, SMINT20026200//1, SMINT20028840//1,
    SMINT20045470//1, SMINT20081330//2, SMINT20092160//1,
    SPLEN20015100//2, SPLEN20017610//1, SPLEN20017810//2,
    SPLEN20024620//2, SPLEN20054500//1, SPLEN20058180//1,
    SPLEN20085910//2, SPLEN20090880//2,
    SPLEN20101950//5, SPLEN20104690//1, SPLEN20105100//2,
    SPLEN20110180//1, SPLEN20121790//1, SPLEN20125230//1,
    SPLEN20136700//1, SPLEN20175920//1, SPLEN20177400//2,
    SPLEN20182850//1, SPLEN20183950//1, SPLEN20190080//1,
    SPLEN20190770//1, SPLEN20193230//1, SPLEN20193790//1,
    SPLEN20204670//1, TESOP10000350//1, TESTI20006160//5,
    TESTI20038240//1, TESTI20043220//1,
    TESTI20046540//1, TESTI20046870//1, TESTI20050400//1,
    TESTI20051730//7, TESTI20053260//2, TESTI20053780//1,
    TESTI20057200//1, TESTI20057590//1, TESTI20061200//10,
    TESTI20062120//1, TESTI20063330//1, TESTI20063410//1,
    TESTI20068530//2, TESTI20070400//10, TESTI20070740//1,
    TESTI20073460//1, TESTI20095200//6, TESTI20095880//10,
    TESTI20100090//1, TESTI20102390//2,
    TESTI20113940//3, TESTI20121040//1, TESTI20149880//3,
    TESTI20151800//3, TESTI20162780//4, TESTI20170170//1,
    TESTI20173050//1, TESTI20186110//11, TESTI20198540//2,
    TESTI20199110//1, TESTI20202830//1, TESTI20204260//1,
    TESTI20214630//2, TESTI20244730//1, TESTI20245860//1,
    TESTI20246410//1, TESTI20257910//1, TESTI20260640//1,
    TESTI20261040//4, TESTI20262150//11,
    TESTI20262940//1, TESTI20264910//1, TESTI20271790//9,
    TESTI20278280//3, TESTI20282420//2, TESTI20282900//1,
    TESTI20286590//1, THYMU20007020//3, THYMU20012020//1,
    THYMU20017270//2, THYMU20020800//4, THYMU20025480//3,
    THYMU20030690//7, THYMU20034790//2, THYMU20046350//1,
    THYMU20050010//5, THYMU20054800//2, THYMU20055740//1,
    THYMU20062770//1, THYMU20078240//1,
    THYMU20079690//2, THYMU20083390//3, THYMU20087270//1,
    THYMU20100940//4, THYMU20106990//1, THYMU20115380//2,
    THYMU20137050//3, THYMU20137570//1, THYMU20143230//2,
    THYMU20145990//3, THYMU20150190//2, THYMU20153210//10,
    THYMU20154790//3, THYMU20163600//2, THYMU20171580//1,
    THYMU20176010//1, THYMU20178440//1, THYMU20185470//2,
    TRACH20011540//2, TRACH20021380//4,
    TRACH20073990//1, TRACH20081270//2, TRACH20149720//1,
    TRACH20149740//1, TRACH20163470//11, TRACH20165330//3,
    TRACH20167090//2, TRACH20173680//8, UMVEN10001380//2,
    UTERU20035770//1, UTERU20045200//5, UTERU20064120//7,
    UTERU20086530//2, UTERU20089300//1, UTERU20095100//3,
    UTERU20099040//5, UTERU20103200//3, UTERU20125810//1,
    UTERU20127150//8, UTERU20139760//1,
    UTERU20188840//2
  • The Names of clones whose deduced amino acid sequences were detected to have functional domains with Pfam, and the name of hit functional domains are as follows. The search result is indicated as “clone name//functional domain name”. When the clone has multiple hit functional domains, they are listed and demarcated by a double slash mark (//). When the clone has multiple hits of an identical functional domain, each is listed without abridgment.
    • ADRGL20020290//Sodium:galactoside symporter family//Nucleoside transporter
    • ADRGL20021910//Immunoglobulin domain
    • ADRGL20026790//PWWP domain
    • ADRGL20036840//Class I Histocompatibility antigen, domains alpha 1 and 2
    • ADRGL20047770//ATP synthase (F/14-kDa) subunit
    • ADRGL20059610//O-Glycosyl hydrolase family 30
    • ADRGL20062330//Spectrin repeat//Spectrin repeat//Bacterial flagellin N-terminus//Spectrin repeat//Spectrin repeat//Spectrin repeat
    • ADRGL20066770//Collagen triple helix repeat (20 copies)//C1q domain
    • ADRGL20079060//Transglutaminase-like superfamily
    • ASTRO20006530//Intermediate filament proteins//Myc leucine zipper domain
    • ASTRO20010010//Photosynthetic reaction center protein
    • ASTRO20010290//PHD-finger
    • ASTRO20026320//Viral (Superfamily 1) RNA helicase//Heavy-metal-associated domain//Viral (Superfamily 1) RNA helicase
    • ASTRO20038400//Homeobox domain//Common central domain of tyrosinase//Rhabdovirus nucleocapsid protein//Homeobox domain//Homeobox domain//Homeobox domain
    • ASTRO20046280//MutT-like domain
    • ASTRO20050810//FGGY family of carbohydrate kinases//FGGY family of carbohydrate kinases
    • ASTRO20052420//RhoGEF domain//PH domain//SH3 domain
    • ASTRO20053430//FERM domain (Band 4.1 family)//FERM domain (Band 4.1 family)//Delta-aminolevulinic acid dehydratase//Lipoprotein amino terminal region
    • ASTRO20055570//Prion protein
    • ASTRO20055930//Aldehyde oxidase and xanthine dehydrogenase, C terminus//Zinc finger, C3HC4 type (RING finger)
    • ASTRO20085080//WD domain, G-beta repeat//Fibrillarin//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • ASTRO20088950//Glycosyl hydrolase family 1
    • BGGI120010750//Phosphoglucose isomerase//Ribosomal protein L7Ae
    • BNGH420015760//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • BNGH420024870//C2 domain//C2 domain//C2 domain
    • BNGH420035290//Zinc finger, C3HC4 type (RING finger)//TRAF-type zinc finger//Hr1 repeat motif//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • BNGH420036410//Arsenical pump membrane protein
    • BNGH420046790//Immunoglobulin domain
    • BNGH420052350//Urotensin II
    • BNGH420059680//NHL repeat//NHL repeat//NHL repeat//NHL repeat
    • BNGH420070370//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • BNGH420074600//RNA polymerase beta subunit
    • BNGH420077980//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
    • BNGH420086030//PH domain//RhoGAP domain
    • BRACE20003310//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • BRACE20007330//BTB/POZ domain//Kelch motif//Kelch motif//Kelch motif//Kelch motif//Kelch motif//Kelch motif
    • BRACE20014450//alpha/beta hydrolase fold
    • BRACE20050870//DEAD/DEAH box helicase
    • BRACE20051600//Reverse transcriptase (RNA-dependent DNA polymerase)
    • BRACE20051930//MAM domain.
    • BRACE20054600//von Willebrand factor type D domain
    • BRACE20055560//WD domain, G-beta repeat//WD domain, G-beta repeat
    • BRACE20059810//TSC-22/dip/bun family
    • BRACE20061620//SPRY domain
    • BRACE20065470//Ubiquitin family
    • BRACE20069000//CLN3 protein
    • BRACE20079200//von Willebrand factor type D domain
    • BRACE20099070//FYVE zinc finger
    • BRACE20196180//HMG (high mobility group) box
    • BRACE20204670//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain//Fatty acid desaturase//Protein-tyrosine phosphatase
    • BRACE20215410//Imidazoleglycerol-phosphate dehydratase//UvrD/REP helicase
    • BRAMY20001510//Zinc finger, C3HC4 type (RING finger)//PHD-finger
    • BRAMY20003540//PH domain//EF hand//EF hand//Viral RNA dependent RNA polymerase//Phosphatidylinositol-specific phospholipase C, X domain//Phosphatidylinositol-specific phospholipase C, Y domain//Bleomycin resistance protein//C2 domain
    • BRAMY20005080//Ubiquitin carboxyl-terminal hydrolase family 2
    • BRAMY20013670//S-adenosylmethionine synthetase
    • BRAMY20016780//Proprotein convertase P-domain
    • BRAMY20023640//UBX domain
    • BRAMY20027990//C2 domain
    • BRAMY20028620//Quinolinate phosphoribosyl transferase
    • BRAMY20035380//Cation efflux family
    • BRAMY20035830//BTB/POZ domain//Thymidylate synthase
    • BRAMY20038980//Granulocyte-macrophage colony-stimulating factor//Borrelia outer surface protein E and F
    • BRAMY20040580//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • BRAMY20043630//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat
    • BRAMY20044920//Ubiquitin carboxyl-terminal hydrolase family 2
    • BRAMY20045420//Domain found in Dishevelled, Egl-10, and Pleckstrin
    • BRAMY20051820//C2 domain
    • BRAMY20056620//Carboxyl transferase domain
    • BRAMY20056840//PWWP domain
    • BRAMY20076100//Ligand-binding domain of nuclear hormone receptor
    • BRAMY20089770//ATP P2X receptor
    • BRAMY20091230//Mitochondrial carrier proteins//Mitochondrial carrier proteins
    • BRAMY20094890//SURF4 family
    • BRAMY20102900//Ephrin
    • BRAMY20111780//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • BRAMY20117670//DnaJ central domain (4 repeats)//DnaJ C terminal region
    • BRAMY20118410//Phospholipase D. Active site motif
    • BRAMY20118490//FGGY family of carbohydrate kinases
    • BRAMY20125360//Asparaginase
    • BRAMY20134050//Nucleosome assembly protein (NAP)
    • BRAMY20143870//Peptidyl-tRNA hydrolase
    • BRAMY20152510//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain
    • BRAMY20158550//EF hand//EF hand
    • BRAMY20206340//WD domain, G-beta repeat//Dockerin domain type I//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • BRAMY20227860//Insulin-like growth factor binding proteins//Spectrin repeat
    • BRAMY20234820//Ribosomal L25p family
    • BRAMY20238630//TPR Domain//TPR Domain//TPR Domain
    • BRAMY20244490//Adenylate kinase
    • BRAMY20245140//Cyclic nucleotide-binding domain
    • BRAMY20251210//Ephrin receptor ligand binding domain//EB module
    • BRAMY20263000//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • BRAMY20274510//Ribosomal protein L11
    • BRAWH20014590//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
    • BRAWH20021910//Carboxylesterases
    • BRAWH20026010//Hepatitis C virus RNA dependent RNA polymerase
    • BRAWH20039640//Leucine rich repeat N-terminal domain//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine rich repeat C-terminal domain//Leucine rich repeat N-terminal domain//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine rich repeat C-terminal domain
    • BRAWH20040680//Zinc finger, C3HC4 type (RING finger)//DENN (AEX-3) domain
    • BRAWH20047790//HMG (high mobility group) box
    • BRAWH20050740//BTB/POZ domain
    • BRAWH20080580//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//DnaJ central domain (4 repeats)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • BRAWH20093040//Eukaryotic protein kinase domain
    • BRAWH20094900//BNR repeat//BNR repeat//BNR repeat
    • BRAWH20095900//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • BRAWH20183170//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat
    • BRAWH20185260//Troponin//Serine hydroxymethyltransferase
    • BRAWH20185270//Uncharacterized protein family UPF0057
    • BRAWH20188750//Glypican//ubiE/COQ5 methyltransferase family
    • BRAWH20191980//Proline dehydrogenase
    • BRCAN1001050//Cell division protein
    • BRCAN20005410//Zinc finger, C4 type (two domains)//Zinc finger, C2HC type//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain
    • BRCOC20000470//TPR Domain//TPR Domain
    • BRSSN20005610//PDZ domain (Also known as DHR or GLGF).
    • BRSSN20005660//Bacterial type II secretion system protein
    • BRSSN20066440//SCAN domain//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • BRSSN20074640//Peptidase family M48
    • BRSSN20093890//Kelch motif//Kelch motif
    • CD34C20001750//Immunoglobulin domain//Immunoglobulin domain
    • CTONG20004110//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Tropomyosins//Transient receptor//Apolipoprotein A1/A4/E family//MutS family, N-terminal putative DNA binding domain//K-box region//Outer membrane efflux protein
    • CTONG20004520//SH3 domain
    • CTONG20007660//Caspase recruitment domain//DNA polymerase (viral) N-terminal domain//bZIP transcription factor//K-box region
    • CTONG20008190//ADP-ribosylation factor family//Ras family
    • CTONG20017490//Sema domain//Sema domain//Integrins, beta chain//Plexin repeat
    • CTONG20020950//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • CTONG20029030//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat
    • CTONG20030280//WD domain, G-beta repeat//Gram-negative pili assembly chaperone//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • CTONG20032930//Armadillo/beta-catenin-like repeats
    • CTONG20033610//RyR domain
    • CTONG20033750//FtsK/SpoIIIE family//ATPases associated with various cellular activities (AAA)
    • CTONG20036990//Immunoglobulin domain//Immunoglobulin domain
    • CTONG20044230//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • CTONG20044870//PH domain//PH domain
    • CTONG20045500//Translation initiation factor IF-3//HCO3-transporter family//HCO3-transporter family//Domain of unknown function DUF139
    • CTONG20046690//Src homology domain 2
    • CTONG20049480//bZIP transcription factor//Carbamoyl-phosphate synthase (CPSase)//tRNA synthetases class I (C)
    • CTONG20060040//NusB family
    • CTONG20063770//KE2 family protein//Spectrin repeat
    • CTONG20063930//SH3 domain//WW domain//WW domain//PH domain//RhoGAP domain
    • CTONG20066110//TPR Domain//TPR Domain
    • CTONG20068360//Mitochondrial carrier proteins//Mitochondrial carrier proteins
    • CTONG20069420//Ribosomal protein S14p/S29e
    • CTONG20070090//Bacterial luciferase
    • CTONG20070720//PH domain//RhoGAP domain//bZIP transcription factor
    • CTONG20070910//PCI domain
    • CTONG20071040//Beta/Gamma crystallin//Beta/Gamma crystallin//Beta/Gamma crystallin//Beta/Gamma crystallin//Similarity to lectin domain of ricin beta-chain, 3 copies.
    • CTONG20071680//3′-5′ exonuclease//Cytochrome c oxidase subunit III//Ammonium Transporter Family//7 transmembrane receptor (Secretin family)
    • CTONG20072930//KRAB box//Ribosomal protein L20//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Putative zinc finger in N-recognin//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • CTONG20074000//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • CTONG20074170//DENN (AEX-3) domain
    • CTONG20076810//Ribosomal protein L16//Pheromone A receptor
    • CTONG20079590//Sialyltransferase family
    • CTONG20083430//Nuclear transition protein 2
    • CTONG20083980//WH1 domain
    • CTONG20084660//SCAN domain
    • CTONG20085210//Lipase (class 3)
    • CTONG20165750//G-patch domain//Double-stranded RNA binding motif
    • CTONG20169040//bZIP transcription factor//Adenylate cyclase//Intermediate filament proteins
    • CTONG20170940//Ank repeat//Ank repeat//Ank repeat//SAM domain (Sterile alpha motif)
    • CTONG20174580//TBC domain
    • CTONG20176040//ADP-ribosylation factor family//Ras family
    • CTONG20180690//Collagen triple helix repeat (20 copies)
    • CTONG20183430//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C3HC4 type (RING finger)
    • CTONG20184830//ABC transporter
    • CTONG20186290//Aldehyde dehydrogenase family
    • CTONG20186370//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • CTONG20186520//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • CTONG20186550//BTB/POZ domain//K+ channel tetramerisation domain
    • CTONG20188080//TPR Domain
    • CTONG20189000//RhoGEF domain
    • CTONG20190290//R3H domain//RNA dependent RNA polymerase//Uncharacterized protein family UPF0024
    • DFNES20025500//Sigma-54 interaction domain//ATPases associated with various cellular activities (AAA)
    • DFNES20043710//Src homology domain 2//Domain of unknown function DUF36
    • DFNES20055400//Viral coat protein//Putative diphthamide synthesis protein//Influenza non-structural protein (NS1)
    • DFNES20057660//Plant thionins//Mitochondrial carrier proteins//Mitochondrial carrier proteins
    • DFNES20072990//Integral membrane protein DUF6//Integral membrane protein DUF6
    • DFNES20073320//Zinc finger, C3HC4 type (RING finger)//PHD-finger//B-box zinc finger.
    • DFNES20076340//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • DFNES20080880//Glycosyl transferases//Similarity to lectin domain of ricin beta-chain, 3 copies.
    • DFNES20094820//PHD-finger//Zn-finger in ubiquitin-hydrolases and other proteins
    • FCBBF10000230//Sec7 domain//PH domain
    • FCBBF10004760//HMG (high mobility group) box
    • FCBBF20018680//C2 domain//C2 domain
    • FCBBF20020440//Urease
    • FCBBF20023490//Helicases conserved C-terminal domain
    • FCBBF20033360//BTB/POZ domain//Kelch motif//Kelch motif//Kelch motif//Kelch motif//Kelch motif
    • FCBBF20035430//AN1-like Zinc finger//AN1-like Zinc finger
    • FCBBF20035490//KH domain
    • FCBBF20041380//SAM domain (Sterile alpha motif)
    • FCBBF20043730//UBA domain
    • FCBBF20059660//TPR Domain
    • FCBBF20066340//PH domain
    • FCBBF20070950//DNA binding domain with preference for A/T rich regions
    • FCBBF30001100//DENN (AEX-3) domain//PPR repeat
    • FCBBF30002270//linker histone H1 and H5 family
    • FCBBF30003610//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Plant PEC family metallothionein//DM DNA binding domain//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)
    • FCBBF30004340//Ribosomal protein S3, C-terminal domain.//Similarity to lectin domain of ricin beta-chain, 3 copies.
    • FCBBF30005360//Sigma-54 interaction domain//ATPases associated with various cellular activities (AAA)//ATPases associated with various cellular activities (AAA)
    • FCBBF30005500//PH domain//PH domain//Putative GTP-ase activating protein for Arf
    • FCBBF30019140//‘chromo’ (CHRromatin Organization MOdifier) domain//‘chromo’ (CHRromatin Organization MOdifier) domain//DEAD/DEAH box helicase//SNF2 and others N-terminal domain//Helicases conserved C-terminal domain
    • FCBBF30019180//Armadillo/beta-catenin-like repeats//Lipoprotein amino terminal region
    • FCBBF30021900//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//BolA-like protein//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Snake toxin//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • FCBBF30022680//3′-5′ exonuclease
    • FCBBF30029250//SET domain
    • FCBBF30035570//C2 domain
    • FCBBF30048420//T-box//wnt family of developmental signaling proteins
    • FCBBF30071500//Influenza RNA-dependent RNA polymerase subunit PB1//Reprolysin family propeptide//Leptin
    • FCBBF30076310//Eukaryotic protein kinase domain//Eukaryotic protein kinase domain//Protein kinase C terminal domain
    • FCBBF30079770//D-isomer specific 2-hydroxyacid dehydrogenases
    • FCBBF30080730//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zinc knuckle
    • FCBBF30085560//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Flavin containing amine oxidase//Phytoene dehydrogenase related enzyme
    • FCBBF30093170//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • FCBBF30100080//Sec7 domain
    • FCBBF30100120//PDZ domain (Also known as DHR or GLGF).
    • FCBBF30100410//Nucleosome assembly protein (NAP)
    • FCBBF30118670//Reprolysin (M12B) family zinc metalloprotease//Disintegrin//EB module//Hantavirus glycoprotein G2//Adenovirus E3 region protein CR2//jmjN domain
    • FCBBF30125460//Zinc finger, C3HC4 type (RING finger)
    • FCBBF30129010//KRAB box//Zinc finger, C2H2 type//GATA zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type
    • FCBBF30130410//UvrB/uvrC motif
    • FCBBF30132050//Galactosyltransferase//Fringe-like
    • FCBBF30132660//Leucine rich repeat N-terminal domain//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat
    • FCBBF30136230//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Cystatin domain//Homeobox domain//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • FCBBF30142290//PHD-finger
    • FCBBF30143550//Phosphatidylinositol-4-phosphate 5-Kinase
    • FCBBF30153170//Phosphofructokinase//Phosphofructokinase//Phosphofructokinase//Phosphofructokinase
    • FCBBF30161780//gag gene protein p24 (core nucleocapsid protein)//Zinc knuckle FCBBF30164510//Cadherin domain//Cadherin domain//Cadherin domain//Fructose-bisphosphate aldolase class-I//Cadherin domain//Cadherin domain//Alphaherpesvirus glycoprotein E//Cadherin cytoplasmic region
    • FCBBF30166220//Serine hydroxymethyltransferase
    • FCBBF30169280//PHD-finger//Zinc finger, C3HC4 type (RING finger)
    • FCBBF30171230//Subtilase family//Proprotein convertase P-domain
    • FCBBF30173960//Beta-lactamase//TPR Domain
    • FCBBF30194550//Arsenical pump membrane protein//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Dehydrogenase E1 component//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat
    • FCBBF30195690//C2 domain
    • FCBBF30197840//Sushi domain (SCR repeat)//CUB domain//Sushi domain (SCR repeat)//CUB domain//Sushi domain (SCR repeat)//Sushi domain (SCR repeat)//Sushi domain (SCR repeat)
    • FCBBF30212210//Immunoglobulin domain
    • FCBBF30215240//PH domain//FERM domain (Band 4.1 family)
    • FCBBF30220050//Ligand-binding domain of nuclear hormone receptor
    • FCBBF30222910//Corticotropin-releasing factor family
    • FCBBF30236670//DEAD/DEAH box helicase
    • FCBBF30250980//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • FCBBF30255680//Vesicular monoamine transporter//GGL domain//Ezrin/radixin/moesin family//Ank repeat//Ank repeat
    • FCBBF30257370//Geminivirus AL1 protein//Outer membrane efflux protein
    • FCBBF30259050//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger present in dystrophin, CBP/p300//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//DM DNA binding domain//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • FCBBF30260210//SNF2 and others N-terminal domain//Helicases conserved C-terminal domain//Domain of unknown function DUF94
    • FCBBF30263080//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • FCBBF30266510//Domain of unknown function DUF71
    • FCBBF30271990//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat
    • FCBBF30275590//LIM domain containing proteins
    • FCBBF30282020//Ank repeat//Ank repeat//Ank repeat//K+ channel tetramerisation domain//BTB/POZ domain
    • FCBBF30285930//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • FCBBF50001650//MORN motif//MORN motif//MORN motif//MORN motif//MORN motif//MORN motif//MORN motif//MORN motif
    • FCBBF50003530//Zinc finger, C3HC4 type (RING finger)
    • FCBBF50004950//Putative replicase 1 (ORF2)
    • FEBRA20005040//Intermediate filament proteins//Hr1 repeat motif//Troponin//GrpE
    • FEBRA20007820//DNA polymerase family B
    • FEBRA20018670//Viral methyltransferase//Ribosomal protein S19//Alpha-2-macroglobulin family N-terminal region
    • FEBRA20026820//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Putative zinc finger in N-recognin//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • FEBRA20027070//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • FEBRA20029620//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat
    • FEBRA20031000//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Insulin/IGF/Relaxin family//Ribosomal RNA adenine dimethylases//SAM domain (Sterile alpha motif)//TFIIE alpha subunit//Zinc finger, C3HC4 type (RING finger)
    • FEBRA20031280//Protein of unknown function DUF82
    • FEBRA20038330//Corticotropin-releasing factor family
    • FEBRA20038970//Laminin EGF-like (Domains III and V)//Phorbol esters/diacylglycerol binding domain (C1 domain)//EGF-like domain//EGF-like domain//Trypsin Inhibitor like cysteine rich domain//Metallothionein//EGF-like domain//EGF-like domain//Extracellular link domain
    • FEBRA20046200//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat
    • FEBRA20046510//Zinc finger, C2H2 type//Zinc finger, C2H2 type//BolA-like protein//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • FEBRA20063720//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • FEBRA20078800//NADH ubiquinone oxidoreductase, 20 Kd subunit
    • FEBRA20080860//Hantavirus glycoprotein G2
    • FEBRA20087550//WD domain, G-beta repeat//WD domain, G-beta repeat
    • FEBRA20088610//CRAL/TR10 domain.
    • FEBRA20088810//Fibroblast growth factor
    • FEBRA20090160//Nuclear transition protein 2
    • FEBRA20090220//Nucleotidyl transferase//Bacterial transferase hexapeptide (four repeats)//Bacterial transferase hexapeptide (four repeats)//Bacterial transferase hexapeptide (four repeats)//Domain of unknown function DUF29//Peptide hormone//eIF4-gamma/eIF5/eIF2-epsilon
    • FEBRA20092760//LIM domain containing proteins//LIM domain containing proteins//LIM domain containing proteins
    • FEBRA20115930//Divalent cation transporter//Translation initiation factor IF-3//Divalent cation transporter
    • FEBRA20150420//Transient receptor//Borrelia ORF-A//Transient receptor FEBRA20170240//SCAN domain//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • FEBRA20172230//Phospholipase D. Active site motif//Phospholipase D. Active site motif
    • FEBRA20173330//Eukaryotic protein kinase domain
    • FEBRA20175330//D-isomer specific 2-hydroxyacid dehydrogenases
    • FEBRA20191720//GGL domain//Regulator of G protein signaling domain
    • HCHON10000150//LIM domain containing proteins//LIM domain containing proteins//LIM domain containing proteins//Zinc finger, C3HC4 type (RING finger)
    • HCHON20000870//Eukaryotic protein kinase domain
    • HCHON20002650//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • HCHON20002710//Ubiquitin carboxyl-terminal hydrolase family 2
    • HCHON20015050//von Willebrand factor type A domain//IPT/TIG domain//Sm protein
    • HEART10001420//MYND finger//SET domain
    • HEART10001490//FAD binding domain
    • HEART20009590//Peptidase family M41
    • HEART20019310//Zinc finger, C3HC4 type (RING finger)//PHD-finger//B-box zinc finger.
    • HEART20022200//Influenza Matrix protein (M1)//metallopeptidase family M24
    • HEART20047640//3′ 5′-cyclic nucleotide phosphodiesterase//Formin Homology 2 Domain
    • HEART20082570//C-5 cytosine-specific DNA methylase//Glycine cleavage T-protein (aminomethyl transferase)
    • HHDPC20081230//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
    • HHDPC20088160//PDZ domain (Also known as DHR or GLGF).
    • HLUNG20008460//bZIP transcription factor
    • HLUNG20011260//Eukaryotic protein kinase domain
    • HLUNG20011460//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
    • HLUNG20014590//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Putative zinc finger in N-recognin//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • HLUNG20015070//Leucine rich repeat N-terminal domain//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine rich repeat C-terminal domain//Immunoglobulin domain
    • HLUNG20024050//Rubredoxin
    • HLUNG20028110//Zinc finger, C3HC4 type (RING finger)//TPR Domain//TPR Domain//TPR Domain//Zinc finger, C3HC4 type (RING finger)//Aldo/keto reductase family
    • HLUNG20030420//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat
    • HLUNG20032460//Prolyl oligopeptidase family//Lipoate-protein ligase B//alpha/beta hydrolase fold
    • HLUNG20033060//HMG (high mobility group) box
    • HLUNG20041590//TPR Domain//TPR Domain//Domain of unknown function DUF27
    • HLUNG20042730//Cytochrome P450
    • HLUNG20051330//FHIPEP family
    • HLUNG20063700//Progesterone receptor
    • HLUNG20065990//bZIP transcription factor//SNAP-25 family//Syntaxin
    • HLUNG20068120//Fimbrial Usher proteins
    • HLUNG20069350//EF hand//EF hand//EF hand
    • HLUNG20070410//Dihydropyridine sensitive L-type calcium channel (Beta subunit)
    • HLUNG20081390//DnaJ domain
    • HLUNG20082350//PH domain//START domain
    • HLUNG20083330//DNA polymerase III beta subunit//Fibrillar collagen C-terminal domain
    • HLUNG20084790//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • HLUNG20085210//C2 domain
    • KIDNE20016360//PAS domain//PAC motif//Ion transport protein//Transmembrane region cyclic Nucleotide Gated Channel//Cyclic nucleotide-binding domain
    • KIDNE20027980//SAM domain (Sterile alpha motif)
    • KIDNE20080690//Glycosyl hydrolases family 18//Aminotransferases class-III pyridoxal-phosphate//Methyl-accepting chemotaxis protein (MCP) signaling domain//Aminotransferases class-III pyridoxal-phosphate
    • KIDNE20081170//Kinesin motor domain//Kinesin motor domain
    • KIDNE20083620//Asparaginase
    • KIDNE20084030//Sugar (and other) transporter
    • KIDNE20084730//Neuraxin and MAP1B proteins//Formin Homology 2 Domain
    • KIDNE20086490//gag gene protein p24 (core nucleocapsid protein)
    • KIDNE20087880//Reverse transcriptase (RNA-dependent DNA polymerase)
    • KIDNE20088240//EF hand//EF hand//EF hand
    • KIDNE20089870//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • KIDNE20094670//Sigma-54 interaction domain//FtsK/SpoIIIE family//ATPases associated with various cellular activities (AAA)
    • KIDNE20133880//G-protein alpha subunit
    • KIDNE20141700//Ribosomal family S4e
    • KIDNE20142900//EGF-like domain//EB module//EGF-like domain//EGF-like domain
    • KIDNE20148080//Zinc finger, C3HC4 type (RING finger)
    • KIDNE20149780//Ank repeat//Ank repeat//Ank repeat
    • KIDNE20152440//Trypsin//PDZ domain (Also known as DHR or GLGF).
    • KIDNE20154330//PDZ domain (Also known as DHR or GLGF).//PDZ domain (Also known as DHR or GLGF).//PDZ domain (Also known as DHR or GLGF).//PDZ domain (Also known as DHR or GLGF).//PDZ domain (Also known as DHR or GLGF).//PDZ domain (Also known as DHR or GLGF).
    • KIDNE20160360//Sec7 domain//PH domain
    • KIDNE20169180//EGF-like domain//EB module//EGF-like domain//Trypsin Inhibitor like cysteine rich domain//EGF-like domain//TNFR/NGFR cysteine-rich region//Zona pellucida-like domain
    • KIDNE20170400//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Protein kinase C terminal domain//Rubredoxin
    • KIDNE20173150//Acetyltransferase (GNAT) family
    • KIDNE20173430//PDZ domain (Also known as DHR or GLGF).//PDZ domain (Also known as DHR or GLGF).
    • KIDNE20186170//UDP-glucoronosyl and UDP-glucosyl transferases
    • KIDNE20189960//Trehalase
    • LIVER20006260//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Plant PEC family metallothionein//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • LIVER20007750//Sugar (and other) transporter
    • LIVER20010760//Lectin C-type domain
    • LIVER20010990//DNA gyrase/topoisomerase IV, subunit A
    • LIVER20013890//tRNA synthetases class I (C)
    • LIVER20026440//Cytochrome P450
    • LIVER20030650//General diffusion Gram-negative porins
    • LIVER20038000//Mitochondrial carrier proteins//Mitochondrial carrier proteins//Mitochondrial carrier proteins
    • LIVER20040740//CRAL/TR10 domain.
    • LIVER20055270//AIR synthase related protein
    • MESAN20006200//Annexin//Annexin
    • MESAN20008150//IBR domain
    • MESAN20009090//CUB domain
    • MESAN20016270//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • MESAN20021130//SH3 domain//Eukaryotic protein kinase domain
    • MESAN20021220//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine rich repeat C-terminal domain//Leucine rich repeat N-terminal domain//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine rich repeat C-terminal domain
    • MESAN20026870//PAN domain//TBC domain
    • MESAN20027240//RhoGEF domain
    • MESAN20027900//von Willebrand factor type A domain//von Willebrand factor type A domain//von Willebrand factor type A domain//Protozoan/cyanobacterial globin//von Willebrand factor type A domain//von Willebrand factor type A domain
    • MESAN20030350//LGN motif, putative GEF specific for G-alpha GTPase//DNA gyrase/topoisomerase IV, subunit A
    • MESAN20030370//Porphobilinogen deaminase//GHMP kinases putative ATP-binding proteins//Protein of unknown function DUF113
    • MESAN20034440//Viral DNA-binding protein//Uncharacterized protein family UPF0024
    • MESAN20038520//Caspase recruitment domain//RNA polymerase beta subunit
    • MESAN20057240//Elongation factor TS//Helix-hairpin-helix motif.
    • MESAN20058110//FKBP-type peptidyl-prolyl cis-trans isomerases//Elongation factor Tu family//FKBP-type peptidyl-prolyl cis-trans isomerases//FKBP-type peptidyl-prolyl cis-trans isomerases
    • MESAN20059570//EGF-like domain//SEA domain//Immunoglobulin domain
    • MESAN20060430//SET domain
    • MESAN20067430//Tropomyosins
    • MESAN20069530//Calponin homology (CH) domain//PDZ domain (Also known as DHR or GLGF).
    • MESAN20090190//EGF-like domain//EGF-like domain//EGF-like domain//EGF-like domain//EGF-like domain//EGF-like domain//Metallothionein//CUB domain
    • MESAN20095220//Adaptin N terminal region
    • MESAN20095800//Cyclophilin type peptidyl-prolyl cis-trans isomerase//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
    • NT2NE20018890//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • NT2NE20026200//Transketolase
    • NT2NE20026510//Zinc finger, C3HC4 type (RING finger)
    • NT2NE20038870//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Lipoprotein
    • NT2NE20042550//Viral (Superfamily 1) RNA helicase//NB-ARC domain//Adenylate kinase//Adenylate kinase
    • NT2NE20053950//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • NT2NE20060750//KRAB box//Zinc finger, C2H2 type
    • NT2NE20061030//SCAN domain
    • NT2NE20077270//Adenovirus EB1 55K protein/large t-antigen
    • NT2NE20079670//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • NT2NE20087270//Tudor domain
    • NT2NE20092950//Fibronectin type III domain
    • NT2NE20108420//Domain of unknown function DUF130//Oxysterol-binding protein
    • NT2NE20117580//NADH ubiquinone oxidoreductase, 20 Kd subunit
    • NT2NE20127900//Myo-inositol-1-phosphate synthase
    • NT2NE20140130//Sema domain
    • NT2NE20145250//Stathmin family
    • NT2NE20153620//FERM domain (Band 4.1 family)//PH domain
    • NT2RI20093010//Tetrahydrofolate dehydrogenase/cyclohydrolase
    • NT2RP70001120//Ank repeat//Ank repeat//Ank repeat//Insulinase (Peptidase family M16)
    • NT2RP70001730//BTB/POZ domain//Kelch motif//Kelch motif//Kelch motif//Kelch motif//Kelch motif
    • NT2RP70003110//Collagen triple helix repeat (20 copies)//Heavy-metal-associated domain
    • NT2RP70027790//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat
    • NT2RP70029780//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)
    • NT2RP70030840//Viral (Superfamily 1) RNA helicase
    • NT2RP70031070//Nucleoside transporter
    • NT2RP70031340//PHD-finger
    • NT2RP70046410//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • NT2RP70056690//Thrombospondin type 1 domain//Domain of unknown function DUF18//Thrombospondin type 1 domain//Thrombospondin type 1 domain//Thrombospondin type 1 domain//Thrombospondin type 1 domain//Keratin, high sulfur B2 protein
    • NT2RP70057500//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//DnaJ central domain (4 repeats)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • NT2RP70064570//Calpain family cysteine protease//Calpain large subunit, domain III//EF hand//EF hand
    • NT2RP70075300//KRAB box//Domain of unknown function DUF19//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • NT2RP70075800//recA bacterial DNA recombination proteins//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//SH3 domain
    • NT2RP70090870//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//DM DNA binding domain//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • NTONG20005310//Ribosomal protein S9/S16
    • NTONG20029850//EF hand//EF hand//EF hand
    • NTONG20031580//Hsp20/alpha crystallin family
    • NTONG20032100//Intermediate filament proteins
    • NTONG20034540//GAF domain//GAF domain//3′ 5′-cyclic nucleotide phosphodiesterase
    • NTONG20035150//BTB/POZ domain//Kelch motif//Kelch motif//Kelch motif//Kelch motif//Kelch motif
    • NTONG20043080//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
    • NTONG20048440//PH domain//K-box region
    • NTONG20053630//DNA binding domain with preference for A/T rich regions//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Progesterone receptor//Zinc finger, C2H2 type
    • NTONG20053730//Ribosomal protein S2//Ubiquitin carboxyl-terminal hydrolases family 2//Ubiquitin carboxyl-terminal hydrolase family 2
    • NTONG20053910//Translin family//PH domain//Putative GTP-ase activating protein for Arf//Ank repeat//Ank repeat
    • NTONG20055200//Calcium channel extracellular region//Elongation factor Tu family//Elongation factor G C-terminus
    • NTONG20058010//AMP-binding enzyme
    • OCBBF20000740//Leucine rich repeat N-terminal domain//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine rich repeat C-terminal domain//Immunoglobulin domain
    • OCBBF20011860//LIM domain containing proteins
    • OCBBF20012520//Leucine rich repeat N-terminal domain//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine rich repeat C-terminal domain//Immunoglobulin domain
    • OCBBF20016390//Chitin synthase//Fibronectin type II domain
    • OCBBF20016810//‘Paired box’ domain
    • OCBBF20110210//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
    • OCBBF20113110//AP endonuclease family 1
    • OCBBF20116250//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type
    • OCBBF20120010//Thrombospondin type 1 domain
    • OCBBF20120950//K+ channel tetramerisation domain//BTB/POZ domain//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • OCBBF20121910//Ribosomal protein L24e
    • OCBBF20147070//DNA polymerase (viral) C-terminal domain
    • OCBBF20156450//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • OCBBF20157970//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//DM DNA binding domain//Zinc finger, C2H2 type
    • OCBBF20165910//DnaB-like helicase
    • OCBBF20166890//CAP-Gly domain//CAP-Gly domain
    • OCBBF20166900//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • OCBBF20167290//haloacid dehalogenase-like hydrolase//Thioredoxin//Aminoglycoside phosphotransferase//Acyl-CoA dehydrogenase
    • OCBBF20174580//Cyclin
    • OCBBF20174890//Death domain
    • OCBBF20175360//Zinc finger, C2H2 type
    • OCBBF20177540//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Src homology domain 2//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • OCBBF20177910//Corticotropin-releasing factor family
    • OCBBF20182060//Inward rectifier potassium channel
    • OCBBF20191950//EGF-like domain//Low-density lipoprotein receptor domain class A//Low-density lipoprotein receptor domain class A//EGF-like domain//Low-density lipoprotein receptor domain class A//EGF-like domain//Low-density lipoprotein receptor domain class A//Low-density lipoprotein receptor domain class A//EGF-like domain//EGF-like domain//Low-density lipoprotein receptor repeat class B//Low-density lipoprotein receptor repeat class B//Low-density lipoprotein receptor repeat class B//Low-density lipoprotein receptor repeat class B//Low-density lipoprotein receptor repeat class B//EGF-like domain//60 Kd inner membrane protein
    • PANCR10000860//Trypsin//Trypsin
    • PEBLM10001470//Zinc finger, C2H2 type//Fork head domain
    • PEBLM20001800//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
    • PEBLM20003260//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Src homology domain 2//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Src homology domain 2//Zinc finger, C2H2 type
    • PEBLM20005020//Virion host shutoff protein
    • PLACE50001390//PHD-finger
    • PLACE60004260//Cystatin domain
    • PLACE60006300//Immunoglobulin domain
    • PLACE60012620//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//AN1-like Zinc finger//FYVE zinc finger
    • PLACE60054230//CheR methyltransferase//Formin Homology 2 Domain
    • PLACE60054820//Regulator of chromosome condensation (RCC1)//Regulator of chromosome condensation (RCC1)//Regulator of chromosome condensation (RCC1)//Regulator of chromosome condensation (RCC1)
    • PLACE60054870//IQ calmodulin-binding motif//IQ calmodulin-binding motif
    • PLACE60055590//Zinc finger, C3HC4 type (RING finger)
    • PLACE60061370//Phosphotyrosine interaction domain (PTB/PID).//Extracellular link domain
    • PLACE60062660//Gamma-adaptin, C-terminus
    • PLACE60064180//Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit.//Viral (Superfamily 1) RNA helicase
    • PLACE60066970//SCAN domain//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • PLACE60070500//Immunoglobulin domain//Immunoglobulin domain
    • PLACE60073090//Myo-inositol-1-phosphate synthase
    • PLACE60074820//Adenylate kinase
    • PLACE60082850//Pathogenesis-related protein Bet v I family
    • PLACE60087680//Thyroglobulin type-1 repeat
    • PLACE60093380//Penicillin amidase//Bacterial regulatory proteins, lacI family//Vacuolar sorting protein 9 (VPS9) domain
    • PLACE60095600//DEAD/DEAH box helicase
    • PLACE60098350//MAGE family
    • PLACE60104630//Photosystem I reaction centre subunit VIII
    • PLACE60113340//EGF-like domain//Laminin G domain//Insulin-like growth factor binding proteins//EGF-like domain//Laminin G domain
    • PLACE60118810//bZIP transcription factor//TPR Domain//TPR Domain//TPR Domain//TPR Domain//PPR repeat
    • PLACE60119700//EF hand
    • PLACE60122970//Zinc finger, C2H2 type
    • PLACE60138840//Syndecan domain//Mitochondrial carrier proteins//Mitochondrial carrier proteins//Mitochondrial carrier proteins
    • PLACE60140640//Phosphoribulokinase//Shikimate kinase//Uncharacterized protein family UPF0038
    • PLACE60154450//RhoGAP domain
    • PLACE60177880//Immunoglobulin domain//Immunoglobulin domain
    • PLACE60181870//Pentaxin family
    • PLACE60184870//LBP/BPI/CETP family
    • PROST10001100//Keratin, high sulfur B2 protein
    • PROST20007170//KRAB box//Zinc finger, C2H2 type//Cyclopropane-fatty-acyl-phospholipid synthase//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • PROST20015210//Myosin tail//Borrelia lipoproteins//Myosin tail
    • PROST20016760//‘chromo’ (CHRromatin Organization MOdifier) domain
    • PROST20024250//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • PROST20028970//Ank repeat//Ank repeat//Glutamine amidotransferases class-II//Ank repeat//Ank repeat
    • PROST20033240//Ephrin receptor ligand binding domain//EB module//TNFR/NGFR cysteine-rich region//Fibronectin type III domain
    • PROST20036350//Glutathione S-transferases.//Ribosomal protein S24e//Interferon alpha/beta domain//tRNA synthetases class I (E and Q)
    • PROST20045700//Keratin, high sulfur B2 protein
    • PROST20050390//Cytochrome P450
    • PROST20051310//DEAD/DEAH box helicase//Toprim domain//Helicases conserved C-terminal domain//Zinc knuckle
    • PROST20065790//Phosphofructokinase//Phosphofructokinase//Phosphofructokinase//Phosphofructokinase
    • PROST20073280//Transposase
    • PROST20075280//Immunoglobulin domain//Immunoglobulin domain//Thrombospondin type 1 domain
    • PROST20082430//Cyclophilin type peptidyl-prolyl cis-trans isomerase
    • PROST20084720//Cytochrome P450
    • PROST20087240//gag gene protein p24 (core nucleocapsid protein)
    • PROST20099090//Disintegrin
    • PROST20102190//EF hand//Ribosomal RNA adenine dimethylases//EF hand
    • PROST20105450//Sodium/hydrogen exchanger family
    • PROST20127450//TSC-22/dip/bun family
    • PROST20130320//S-100/ICaBP type calcium binding domain
    • PROST20152510//TPR Domain//TPR Domain//TPR Domain
    • PROST20155370//SCAN domain//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • PROST20168600//KTN NAD-binding domain
    • PUAEN10000650//TSC-22/dip/bun family
    • PUAEN10001640//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat
    • PUAEN20000800//Bleomycin resistance protein
    • PUAEN20001520//Acetyltransferase (GNAT) family
    • PUAEN20002470//FtsK/SpoIIIE family
    • PUAEN20003120//Myb-like DNA-binding domain//ATP synthase ab C terminal//SET domain
    • SALGL10001070//Family 4 glycosyl hydrolase
    • SKMUS20006790//von Willebrand factor type D domain
    • SKMUS20007260//Syndecan domain
    • SKMUS20008730//Calponin homology (CH) domain
    • SKMUS20017400//Hantavirus nucleocapsid protein//Tropomyosins
    • SKMUS20040440//Ribosomal protein L3
    • SKMUS20091900//Trypsin
    • SKNMC10001230//Ank repeat//Ank repeat//Ank repeat
    • SKNMC20006350//FKBP-type peptidyl-prolyl cis-trans isomerases//FKBP-type peptidyl-prolyl cis-trans isomerases//FKBP-type peptidyl-prolyl cis-trans isomerases//EF hand//EF hand
    • SKNSH20009710//Tropomyosins//Tropomyosins
    • SKNSH20052400//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • SKNSH20057920//Eukaryotic protein kinase domain
    • SMINT20000070//Rabphilin-3A effector domain
    • SMINT20002320//Protein phosphatase 2A regulatory B subunit (B56 family)
    • SMINT20006020//PH domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//FYVE zinc finger//PH domain
    • SMINT20006090//Glutathione S-transferases.
    • SMINT20008110//Na+/K+ ATPase C-terminus
    • SMINT20011950//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type
    • SMINT20012220//Collagen triple helix repeat (20 copies)
    • SMINT20016150//gag gene protein p17 (matrix protein).//Ferritins
    • SMINT20024140//Immunoglobulin domain
    • SMINT20028800//Zinc finger, C2HC type//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain
    • SMINT20028840//Immunoglobulin domain
    • SMINT20030740//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • SMINT20035050//SH3 domain//WW domain//PH domain//RhoGAP domain
    • SMINT20036440//ENTH domain
    • SMINT20038660//Olfactomedin-like domain
    • SMINT20039050//Flavivirus glycoprotein//IBR domain
    • SMINT20043390//Ras association (RalGDS/AF-6) domain
    • SMINT20044140//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • SMINT20044730//Envelope glycoprotein GP120
    • SMINT20048720//Cytochrome P450//Cytochrome P450
    • SMINT20052130//Ank repeat//Ank repeat
    • SMINT20056230//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
    • SMINT20062050//Reverse transcriptase (RNA-dependent DNA polymerase)
    • SMINT20077960//Gelsolin repeat.//Gelsolin repeat.//Gelsolin repeat.//Gelsolin repeat.
    • SMINT20083290//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
    • SMINT20086250//Glycine cleavage H-protein
    • SMINT20086720//SCAN domain//KRAB box
    • SMINT20088440//Immunoglobulin domain
    • SMINT20089600//PDZ domain (Also known as DHR or GLGF).
    • SMINT20091190//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
    • SPLEN20006950//Reverse transcriptase (RNA-dependent DNA polymerase)
    • SPLEN20011350//Helper component proteinase
    • SPLEN20015100//DHHC zinc finger domain
    • SPLEN20023540//RasGEF domain//EF hand//EF hand
    • SPLEN20023850//RecF protein//SMC domain N terminal domain//Tropomyosins
    • SPLEN20024190//EGF-like domain//EB module//EGF-like domain//Trypsin Inhibitor like cysteine rich domain//EGF-like domain//EGF-like domain//WAP-type (Whey Acidic Protein) ‘four-disulfide core’//EGF-like domain
    • SPLEN20024930//Inositol polyphosphate phosphatase family, catalytic domain
    • SPLEN20039180//Fatty acid desaturase
    • SPLEN20042200//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • SPLEN20049840//Polyphosphate kinase//Myosin head (motor domain)//IQ calmodulin-binding motif//SH3 domain
    • SPLEN20050090//Pyridoxamine 5′-phosphate oxidase//GRIP domain
    • SPLEN20054500//Renal dipeptidase
    • SPLEN20055600//K+ channel tetramerisation domain//BTB/POZ domain//Zinc finger, C2H2 type
    • SPLEN20057900//Scorpion short toxins//EGF-like domain//EGF-like domain//Keratin, high sulfur B2 protein
    • SPLEN20059270//Zinc finger, C3HC4 type (RING finger)//B-box zinc finger.//SPRY domain
    • SPLEN20063250//Zinc finger, C2H2 type
    • SPLEN20063890//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat
    • SPLEN20071820//DNA polymerase X family
    • SPLEN20076470//TPR Domain//TPR Domain//TPR Domain
    • SPLEN20080070//Alpha-L-fucosidase
    • SPLEN20085910//Double-stranded RNA binding motif
    • SPLEN20090880//Immunoglobulin domain
    • SPLEN20098030//Zinc finger, C3HC4 type (RING finger)//B-box zinc finger.
    • SPLEN20101950//Sodium/hydrogen exchanger family
    • SPLEN20104150//Ribosomal protein L36
    • SPLEN20108000//short chain dehydrogenase
    • SPLEN20110180//Transposase
    • SPLEN20118050//Leucine rich repeat N-terminal domain//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat
    • SPLEN20135030//PDZ domain (Also known as DHR or GLGF).//GATA zinc finger//LIM domain containing proteins
    • SPLEN20139100//Sodium and potassium ATPases//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
    • SPLEN20139360//Bacterial regulatory proteins, lacI family//Site-specific recombinases
    • SPLEN20175920//Uncharacterized protein family UPF0036
    • SPLEN20180980//Glutathione S-transferases.
    • SPLEN20182990//BTB/POZ domain//Kelch motif//Kelch motif//Kelch motif//Kelch motif
    • SPLEN20183020//Laminin G domain
    • SPLEN20191020//Src homology domain 2
    • SPLEN20193790//Dynamin family//Dynamin family//Proteasome activator pa28 beta subunit//Peroxidase//Dynamin central region//Dynamin GTPase effector domain
    • SPLEN20195710//TPR Domain//TPR Domain//TPR Domain
    • SPLEN20197930//K-box region
    • SPLEN20198390//WD domain, G-beta repeat//Fibrillarin//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • SPLEN20201830//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat
    • TESTI10001570//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type
    • TESTI20006160//Large-conductance mechanosensitive channel, MscL//CbiM
    • TESTI20006830//PWWP domain
    • TESTI20012080//Chitin synthase
    • TESTI20016970//TPR Domain
    • TESTI20030200//Double-stranded RNA binding motif//Adenosine-deaminase (editase) domain//Adenosine-deaminase (editase) domain
    • TESTI20030440//Plant PEC family metallothionein//Tropomyosins
    • TESTI20031310//Serpins (serine protease inhibitors)
    • TESTI20038240//Peptidase family M13
    • TESTI20041630//Outer membrane efflux protein//Intermediate filament proteins
    • TESTI20043910//IQ calmodulin-binding motif//IQ calmodulin-binding motif//IQ calmodulin-binding motif//IQ calmodulin-binding motif//IQ calmodulin-binding motif
    • TESTI20045390//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobul in domain//Immunoglobul in domain//Immunoglobulin domain//Immunoglobulin domain
    • TESTI20046110//Extracellular link domain
    • TESTI20046490//LIM domain containing proteins//Somatomedin B domain
    • TESTI20046870//CRAL/TR10 domain.//CRAL/TR10 domain.//MSP (Major sperm protein) domain
    • TEST120046890//PHD-finger
    • TESTI20049060//Immunoglobulin domain
    • TESTI20049410//Proprotein convertase P-domain
    • TESTI20050720//Coenzyme A transferase//Alpha-2-macroglobulin family N-terminal region//Coenzyme A transferase
    • TESTI20051730//Glutamine amidotransferases class-II//alpha/beta hydrolase fold
    • TESTI20053070//WD domain, G-beta repeat//WD domain, G-beta repeat
    • TESTI20053950//IQ calmodulin-binding motif
    • TESTI20055880//Serum amyloid A protein
    • TESTI20056030//Myosin tail
    • TESTI20057430//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • TESTI20057590//Leucine rich repeat C-terminal domain//Immunoglobulin domain
    • TESTI20057840//SAP domain//Zinc knuckle//Zinc finger, C3HC4 type (RING finger)
    • TESTI20057880//Zinc finger, C3HC4 type (RING finger)
    • TESTI20058350//Polyomavirus coat protein//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • TESTI20058920//Tubulin/FtsZ family
    • TESTI20059080//Thermophilic metalloprotease (M29)//Hyaluronidase
    • TESTI20059480//Cyclic nucleotide-binding domain
    • TESTI20059810//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//DM DNA binding domain//Zinc finger, C2H2 type//Zinc finger, C2H2 type//BolA-like protein//Zinc finger, C2H2-type//Coronavirus M matrix/glycoprotein//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • TESTI20060350//bZIP transcription factor
    • TESTI20060830//ZAP domain//Ferric uptake regulator family//Peptidase family M1//Piwi domain
    • TESTI20061090//Keratin, high sulfur B2 protein
    • TESTI20061200//Sugar (and other) transporter
    • TESTI20064370//TPR Domain//TPR Domain//TPR Domain//TPR Domain//Synaptobrevin
    • TESTI20064530//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • TESTI20064650//Myosin head (motor domain)
    • TESTI20065650//G-protein alpha subunit
    • TESTI20066150//Picornavirus 2B protein//Glutamine amidotransferase class-I//Pancreatic hormone peptides
    • TESTI20066330//Fibronectin type III domain
    • TESTI20066650//RasGEF domain
    • TESTI20067480//KRAB box//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//FYVE zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • TESTI20068530//Zinc finger, C3HC4 type (RING finger)//PHD-finger
    • TESTI20071130//ATP synthase Alpha chain, C terminal
    • TESTI20071630//Glutamine synthetase//SCP-like extracellular protein
    • TESTI20075240//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Putative zinc finger in N-recognin//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • TESTI20076570//Dual specificity phosphatase, catalytic domain
    • TESTI20079220//KRAB box//Myb-like DNA-binding domain//Myb-like DNA-binding domain//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • TESTI20079980//PDZ domain (Also known as DHR or GLGF).//Domain found in Dishevelled, Egl-10, and Pleckstrin
    • TESTI20081890//PDZ domain (Also known as DHR or GLGF).
    • TESTI20084250//Oxysterol-binding protein
    • TESTI20086840//von Willebrand factor type A domain
    • TESTI20088840//Zinc finger, C3HC4 type (RING finger)//PHD-finger//Thymidine kinases//E7 protein, Early protein//CONSTANS family zinc finger//B-box zinc finger.//SPRY domain
    • TESTI20092170//ENV polyprotein (coat polyprotein)
    • TEST120095200//7TM chemoreceptor
    • TESTI20095770//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • TESTI20095880//Domain of unknown function DUF33//Penicillin amidase//Formate/nitrite transporter//Sodium:galactoside symporter family
    • TESTI20099350//GGL domain//Clusterin//Biopterin-dependent aromatic amino acid hydroxylase
    • TESTI20100090//Lectin C-type domain
    • TESTI20104090//TEA domain
    • TESTI20105910//Notch (DSL) domain//Amiloride-sensitive sodium channel
    • TESTI20106170//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • TESTI20106820//Protein kinase C terminal domain
    • TESTI20108060//Ser/Thr protein phosphatase
    • TESTI20112540//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Chorismate synthase//UvrB/uvrC motif
    • TESTI20112860//Eukaryotic protein kinase domain
    • TESTI20113940//Divalent cation transporter
    • TEST120114480//Zinc finger, C4 type (two domains)//Zinc finger, C2HC type//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain
    • TESTI20116050//UBX domain
    • TESTI20120500//Kelch motif//Kelch motif
    • TESTI20120900//DNA gyrase/topoisomerase IV, subunit A
    • TESTI20121040//Protein phosphatase 2C//Protein phosphatase 2C
    • TESTI20122070//ELM2 domain//Myb-like DNA-binding domain
    • TESTI20125280//Immunoglobulin domain//Immunoglobulin domain
    • TESTI20125920//PCI domain
    • TESTI20126280//recA bacterial DNA recombination proteins
    • TESTI20131440//Carboxypeptidase activation peptide//Zinc carboxypeptidase
    • TESTI20132310//Ubiquitin carboxyl-terminal hydrolase family 2
    • TESTI20134680//MYND finger//B-box zinc finger.//CONSTANS family zinc finger//Putative zinc finger in N-recognin
    • TESTI20134970//Double-stranded RNA binding motif//Aldehyde oxidase and xanthine dehydrogenase, C terminus//Adenosine-deaminase (editase) domain
    • TESTI20140970//Immunoglobulin domain
    • TESTI20145780//Src homology domain 2
    • TESTI20148380//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//PPR repeat//Neuraminidases//ATP synthase Alpha chain, C terminal//TPR Domain//TPR Domain//TPR Domain//TPR Domain//PPR repeat//TPR Domain
    • TESTI20150420//RhoGAP domain
    • TESTI20150920//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat
    • TESTI20153310//Intermediate filament tail domain
    • TESTI20162780//Divalent cation transporter
    • TESTI20162980//Ubiquitin family//Retroviral aspartyl protease//Retroviral aspartyl protease
    • TESTI20164210//Isocitrate and isopropylmalate dehydrogenases//Ribosomal protein S27a//TILa domain//von Willebrand factor type C domain
    • TESTI20165990//Ribosomal protein L36
    • TESTI20166290//Zinc finger, C2H2 type//FAD binding domain//Phosphoenolpyruvate carboxykinase//Ribosomal protein S11
    • TESTI20166670//Zinc finger C-x8-C-x5-C-x3-H type (and similar).
    • TESTI20169500//GGL domain
    • TESTI20170280//Flagellar L-ring protein
    • TESTI20173960//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type t
    • TESTI20179230//Dihydropyridine sensitive L-type calcium channel (Beta subunit)
    • TESTI20182760//Amiloride-sensitive sodium channel
    • TESTI20183680//Gas vesicles protein GVPc repeated domain
    • TESTI20184750//Laminin G domain//Thrombospondin N-terminal-like domains//Laminin G domain
    • TESTI20184760//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • TESTI20186110//Divalent cation transporter//Translation initiation factor IF-3//Divalent cation transporter
    • TESTI20193080//Growth-Arrest-Specific Protein 2 Domain
    • TESTI20194880//SAP domain
    • TESTI20196690//Glycine cleavage T-protein (aminomethyl transferase)
    • TEST120197030//Pancreatic hormone peptides
    • TESTI20197600//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • TESTI20199110//Disintegrin
    • TESTI20205100//DNA gyrase/topoisomerase IV, subunit A
    • TESTI20205250//MORN motif//MORN motif//MORN motif//MORN motif//MORN motif//MORN motif//MORN motif
    • TESTI20207170//Nucleosome assembly protein (NAP)
    • TESTI20210570//CRAL/TR10 domain.
    • TESTI20212970//DEAD/DEAH box helicase//Helicases conserved C-terminal domain
    • TESTI20219110//Eukaryotic protein kinase domain
    • TESTI20222030//Hemagglutinin//ATP synthase Alpha chain, C terminal//AMP-binding enzyme
    • TESTI20222460//Intermediate filament proteins
    • TESTI20227380//DEAD/DEAH box helicase//Helicases conserved C-terminal domain
    • TESTI20228120//RhoGAP domain
    • TESTI20228740//Zinc finger, C2H2 type
    • TESTI20244220//Cecropin family//Fes/CIP4 homology domain//Hr1 repeat motif//SH3 domain
    • TESTI20244430//Ank repeat//Ank repeat//Ank repeat//SAM domain (Sterile alpha motif)
    • TESTI20244460//pKID domain//Adenylate kinase//Thymidylate kinase//ATPases associated with various cellular activities (AAA)
    • TESTI20246480//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
    • TESTI20251610//Chitin synthase//von Willebrand factor type A domain
    • TESTI20252690//Domain found in Dishevelled, Egl-10, and Pleckstrin
    • TESTI20254030//LIM domain containing proteins//LIM domain containing proteins//Villin headpiece domain
    • TESTI20254990//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • TESTI20255460//ZAP domain//Piwi domain
    • TESTI20257910//Class I Histocompatibility antigen, domains alpha 1 and 2//Immunoglobulin domain
    • TESTI20258720//Ank repeat//Ank repeat//Ank repeat
    • TESTI20259110//Zinc finger, C3HC4 type (RING finger)//PHD-finger
    • TESTI20261040//DNA polymerase (viral) C-terminal domain
    • TESTI20261160//PH domain
    • TESTI20261680//Hsp20/alpha crystallin family//Granulins
    • TESTI20262150//Ion transport protein
    • TESTI20262940//Phosphofructokinase
    • TESTI20264530//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//C. elegans integral membrane protein Srb//WD domain, G-beta repeat//WD domain, G-beta repeat//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain
    • TESTI20264910//Uteroglobin family
    • TESTI20266050//Zinc finger, C3HC4 type (RING finger)//SPRY domain
    • TESTI20274960//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • TESTI20278280//PMP-22/EMP/MP20/Claudin family
    • TESTI20282530//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • TESTI20284260//Histone-like transcription factor (CBF/NF-Y) and archaeal histone//Core histone H2A/H2B/H3/H4
    • TESTI20285230//Adenosine-deaminase (editase) domain
    • THYMU10004280//NHL-repeat//NHL repeat
    • THYMU20006020//Isocitrate and isopropylmalate dehydrogenases
    • THYMU20009500//TPR Domain
    • THYMU20013250//LIM domain containing proteins//RI01/ZK632.3/MJ0444 family//Eukaryotic protein kinase domain
    • THYMU20018250//TPR Domain
    • THYMU20019260//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • THYMU20021090//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain
    • THYMU20028150//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
    • THYMU20028410//BRCA1 C Terminus (BRCT) domain//BRCA1 C Terminus (BRCT) domain
    • THYMU20031330//4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family
    • THYMU20032820//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • THYMU20039320//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • THYMU20046350//Cytochrome C and Quinol oxidase polypeptide I
    • THYMU20049060//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
    • THYMU20052830//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
    • THYMU20055450//Zona pellucida-like domain
    • THYMU20055460//Putative esterase
    • THYMU20055760//Na+/K+ ATPase C-terminus//Phospholipase A2
    • THYMU20062770//Zona pellucida-like domain
    • THYMU20063650//Ribulose-phosphate 3 epimerase family//Indole-3-glycerol phosphate synthases
    • THYMU20066660//DEAD/DEAH box helicase
    • THYMU20070250//Transketolase//Dehydrogenase E1 component//Transketolase
    • THYMU20071120//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • THYMU20077250//HMG (high mobility group) box
    • THYMU20081110//LIM domain containing proteins
    • THYMU20083390//11S plant seed storage protein
    • THYMU20090230//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
    • THYMU20095920//Iron hydrogenase small subunit
    • THYMU20097920//PH domain//FERM domain (Band 4.1 family)
    • THYMU20098350//bZIP transcription factor//bZIP transcription factor//Tubulin/FtsZ family//Intermediate filament proteins
    • THYMU20099060//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
    • THYMU20100940//Protein of unknown function DUF132
    • THYMU20104480//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
    • THYMU20106990//PH domain
    • THYMU20110720//Aminotransferases class-III pyridoxal-phosphate
    • THYMU20112590//Acyl-CoA dehydrogenase//Adaptin N terminal region
    • THYMU20120240//Ubiquitin carboxyl-terminal hydrolases family 2//Ubiquitin carboxyl-terminal hydrolase family 2
    • THYMU20120730//Aldehyde dehydrogenase family
    • THYMU20121040//bZIP transcription factor//EF-1 guanine nucleotide exchange domain
    • THYMU20139160//Uncharacterized protein family UPF0031
    • THYMU20143230//EGF-like domain//Extracellular link domain//Fasciclin domain
    • THYMU20145990//SH3 domain
    • THYMU20153210//7 transmembrane receptor (Secretin family)
    • THYMU20170230//Glycine cleavage T-protein (aminomethyl transferase)
    • THYMU20176010//WD domain, G-beta repeat//PQQ enzyme repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • THYMU20178440//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
    • THYMU20184550//HSF-type DNA-binding domain//bZIP transcription factor
    • THYMU20191970//Cadherin domain//Cadherin domain//Cadherin domain//Cadherin domain
    • TKIDN10000620//Thioredoxin
    • TKIDN10001920//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • TRACH20011010//5′-nucleotidase
    • TRACH20021380//Copper/zinc superoxide dismutase (SODC)//Adenylate and Guanylate cyclase catalytic domain//Adenylate and Guanylate cyclase catalytic domain
    • TRACH20029880//MORN motif//MORN motif//Penicillin amidase//Bacterial regulatory proteins, lacI family//Vacuolar sorting protein 9 (VPS9) domain
    • TRACH20040390//Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain)//Pumilio-family RNA binding domains (aka PUM-HID, Pumilio homology domain)//Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain)//Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain)//Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain)//Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain)//Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain)//Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain)
    • TRACH20043360//Kinesin motor domain//Caspase recruitment domain//Ribosomal protein L35
    • TRACH20058000//Fibronectin type III domain
    • TRACH20090060//C2 domain
    • TRACH20091070//Aldehyde dehydrogenase family
    • TRACH20093400//Adaptin N terminal region
    • TRACH20098510//Ribosomal L29 protein
    • TRACH20104510//Uncharacterized protein family UPF0005
    • TRACH20108240//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
    • TRACH20113020//AIR synthase related protein
    • TRACH20122980//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain
    • TRACH20131230//PH domain//Oxysterol-binding protein
    • TRACH20139280//PX domain
    • TRACH20143710//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat
    • TRACH20149500//Zinc finger//Plexin repeat//Cysteine rich repeat//Intermediate filament proteins
    • TRACH20149740//Sodium:dicarboxylate symporter family
    • TRACH20163470//Putative integral membrane protein DUF46//Sugar (and other) transporter//Sodium:galactoside symporter family
    • TRACH20164100//Retroviral aspartyl protease
    • TRACH20164810//D-isomer specific 2-hydroxyacid dehydrogenases
    • TRACH20167090//Chitinases, family 2
    • TRACH20170860//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
    • TRACH20188350//Tropomyosins
    • TRACH20190460//Lipase (class 3)
    • UTERU20000950//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
    • UTERU20016580//Zinc finger present in dystrophin, CBP/p300//Myb-like DNA-binding domain
    • UTERU20026620//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • UTERU20041630//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type
    • UTERU20083020//Domain of unknown function DUF71
    • UTERU20086530//Lipocalin/cytosolic fatty-acid binding protein family
    • UTERU20087070//Sushi domain (SCR repeat)//Trypsin
    • UTERU20089390//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain
    • UTERU20089620//Fringe-like
    • UTERU20099040//Cation efflux family
    • UTERU20099510//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type
    • UTERU20104310//RNA polymerases K/14 to 18 kDa subunit
    • UTERU20121140//Rhodanese-like domain
    • UTERU20122520//FERM domain (Band 4.1 family)//FERM domain (Band 4.1 family)
    • UTERU20127030//Xylose isomerase//ApbE family
    • UTERU20127150//Translation initiation factor IF-3//Divalent cation transporter
    • UTERU20128560//Domain of unknown function DUF28
    • UTERU20132620//HMG14 and HMG17
    • UTERU20139760//Mitochondrial carrier proteins//Mitochondrial carrier proteins
    • UTERU20168960//PH domain//Methanol dehydrogenase beta subunit
    • UTERU20181270//Zinc knuckle
    • UTERU20185220//Bromodomain
    EXAMPLE 6 Functional Categorization Based on the Full-Length Nucleotide Sequences
  • The functional prediction and categorization of the proteins encoded by the clones were carried out based on the result of homology search of the databases of GenBank, Swiss-Prot, UniGene and nr (see the Homology Search Result Data) for the full-length nucleotide sequences and the result of domain search of the amino acid sequences deduced from the full-length nucleotide sequences (see Example 5).
  • The clone predicted to belong to the category of secretory protein/membrane protein means a clone having hit data with some annotation, such as growth factor, cytokine, hormone, signal, transmembrane, membrane, extracellular matrix, receptor, G-protein coupled receptor, ionic channel, voltage-gated channel, calcium channel, cell adhesion, collagen, connective tissue, etc., suggesting that it is a secretory or membrane protein, or means a clone in which the presence of nucleotide sequence encoding a signal sequence or transmembrane domain was suggested by the results of PSORT and SOSUI analyses for deduced ORF.
  • The clone predicted to belong to the category of glycoprotein-related protein means a clone having hit data with some annotation, such as glycoprotein, suggesting that the clone encodes a glycoprotein-related protein.
  • The clone predicted to belong to the category of signal transduction-related protein means a clone having hit data with some annotation, such as serine/threonine-protein kinase, tyrosine-protein kinase, SH3 domain, SH2 domain, etc., suggesting that the clone encodes a signal transduction-related protein.
  • The clone predicted to belong to the category of transcription-related protein means a clone having hit data with some annotation, such as transcription regulation, zinc finger, homeobox, etc., suggesting that the clone encodes a transcription-related protein.
  • The clone predicted to belong to the category of disease-related protein means a clone having hit data with some annotation, such as disease mutation, syndrome, etc., suggesting that the clone encodes a disease-related protein, or means a clone whose full-length nucleotide sequence has hit data for Swiss-Prot, GenBank, or UniGene, where the hit data corresponds to genes or proteins which have been deposited in the Online Mendelian Inheritance in Man (OMIM) (http://www.ncbi.nlm.nih.gov/Omim/), which is the human gene and disease database.
  • The clone predicted to belong to the category of enzyme and/or metabolism-related protein means a clone having hit data with some annotation, such as metabolism, oxidoreductase, E. C. No. (Enzyme commission number), etc., suggesting that the clone encodes an enzyme and/or metabolism-related protein.
  • The clone predicted to belong to the category of cell division and/or cell proliferation-related protein means a clone having hit data with some annotation, such as cell division, cell cycle, mitosis, chromosomal protein, cell growth, apoptosis, etc., suggesting that the clone encodes a cell division and/or cell proliferation-related protein.
  • The clone predicted to belong to the category of cytoskeleton-related protein means a clone having hit data with some annotation, such as structural protein, cytoskeleton, actin-binding, microtubles, etc., suggesting that the clone encodes a cytoskeleton-related protein.
  • The clone which is predicted to belong to the category of nuclear protein and/or RNA synthesis-related protein means a clone having hit data with some annotation, such as nuclear protein, RNA splicing, RNA processing, RNA helicase, polyadenylation, etc., suggesting that the clone encodes a nuclear protein and/or RNA synthesis-related protein.
  • The clone predicted to belong to the category of protein synthesis and/or transport-related protein means a clone having hit data with some annotation, such as translation regulation, protein biosynthesis, amino-acid biosynthesis, ribosomal protein, protein transport, signal recognition particle, etc., suggesting that the clone encodes a protein synthesis and/or transport-related protein.
  • The clone predicted to belong to the category of cellular defense-related protein means a clone having hit data with some annotation, such as heat shock, DNA repair, DNA damage, etc., suggesting that the clone encodes a cellular defense-related protein.
  • The clone predicted to belong to the category of development and/or differentiation-related proteins means a clone having hit data with some annotation, such as developmental protein, etc., suggesting that the clone encodes a development and/or differentiation-related protein.
  • The clone predicted to belong to the category of DNA-binding and/or RNA-binding protein means a clone having hit data with some annotation, such as DNA-binding, RNA-binding, etc.
  • The clone predicted to belong to the category of ATP-binding and/or GTP-binding protein means a clone having hit data with some annotation, such as ATP-binding, GTP-binding, etc.
  • In this functional categorization, when a single clone corresponded to multiple categories of those shown above, the clone was assigned to the multiple categories. However, the function of a protein is not restricted to the functional category in this classification, and there is the possibility that other functions are newly assigned to the protein.
  • The clones predicted to belong to the category of secretory protein and/or membrane protein are the following 516 clones.
    ADRGL20020290, ADRGL20021910, ADRGL20036380, ADRGL20036840,
    ADRGL20059610, ADRGL20063770, ADRGL20066770, ASTRO20010010,
    ASTRO20020240, ASTRO20045840, ASTRO20053430, ASTRO20055530,
    ASTRO20055570, ASTRO20055930, ASTRO20088950, ASTRO20091180,
    BNGH420021680, BNGH420023870, BNGH420046790, BNGH420052350,
    BNGH420059680, BNGH420075940, BNGH420077980, BRACE10000510,
    BRACE20051930, BRACE20052530, BRACE20054080, BRACE20066360,
    BRACE20068710, BRACE20069000, BRACE20069110, BRACE20194670,
    BRACE20204670, BRACE20216950, BRAMY10001730, BRAMY20003880,
    BRAMY20013670, BRAMY20024790, BRAMY20027390, BRAMY20028530,
    BRAMY20035380, BRAMY20044920, BRAMY20045210, BRAMY20047560,
    BRAMY20050940, BRAMY20053910, BRAMY20055760, BRAMY20072440,
    BRAMY20083820, BRAMY20089770, BRAMY20091230, BRAMY20094890,
    BRAMY20096930, BRAMY20118410, BRAMY20123400, BRAMY20125550,
    BRAMY20127310, BRAMY20127760, BRAMY20135720, BRAMY20137360,
    BRAMY20139440, BRAMY20152510, BRAMY20194680, BRAMY20204270,
    BRAMY20225320, BRAMY20237190, BRAMY20245140, BRAMY20251750,
    BRAMY20285650, BRAWH20020470, BRAWH20021910, BRAWH20026010,
    BRAWH20030000, BRAWH20039640, BRAWH20055330, BRAWH20078620,
    BRAWH20093070, BRAWH20185270, BRCAN10000760, BRCAN10001680,
    BRCAN20001480, BRCAN20004180, BRCAN20005230, BRCOC20000470,
    BRCOC20003600, BRHIP10000720, BRHIP10001040, BRHIP20000210,
    BRSSN20001970, BRSSN20074640, BRSSN20091190, CD34C20001750,
    CTONG20017490, CTONG20036990, CTONG20041260, CTONG20044870,
    CTONG20045500, CTONG20049480, CTONG20051450, CTONG20055850,
    CTONG20056150, CTONG20059130, CTONG20060040, CTONG20063770,
    CTONG20065680, CTONG20068360, CTONG20069320, CTONG20071680,
    CTONG20076810, CTONG20078340, CTONG20079590, CTONG20083980,
    CTONG20084020, CTONG20085210, CTONG20167750, CTONG20168240,
    CTONG20179890, CTONG20183830, CTONG20184830, DFNES20018000,
    DFNES20029660, DFNES20057660, DFNES20072990, DFNES20080880,
    FCBBF20018680, FCBBF20029280, FCBBF20032930, FCBBF20036360,
    FCBBF20054390, FCBBF30004340, FCBBF30022680, FCBBF30029250,
    FCBBF30042610, FCBBF30062490, FCBBF30075970, FCBBF30078600,
    FCBBF30091520, FCBBF30095410, FCBBF30105440, FCBBF30118670,
    FCBBF30132660, FCBBF30135890, FCBBF30145670, FCBBF30164510,
    FCBBF30169870, FCBBF30171230, FCBBF30172330, FCBBF30177290,
    FCBBF30179740, FCBBF30195690, FCBBF30197840, FCBBF30212210,
    FCBBF30223110, FCBBF30223210, FCBBF30225930, FCBBF30230610,
    FCBBF30260480, FCBBF30266510, FCBBF30287940, FCBBF50000610,
    FCBBF50004950, FEBRA20007820, FEBRA20018670, FEBRA20031280,
    FEBRA20031810, FEBRA20038220, FEBRA20039260, FEBRA20040230,
    FEBRA20040560, FEBRA20046280, FEBRA20080860, FEBRA20084750,
    FEBRA20088810, FEBRA20115930, FEBRA20116650, FEBRA20121950,
    FEBRA20141980, FEBRA20177800, FEBRA20182030, FEBRA20191720,
    HCHON10001660, HCHON20015050, HEART10001490, HEART20031680,
    HHDPC10001140, HHDPC20051850, HHDPC20082790, HHDPC20088160,
    HLUNG20015070, HLUNG20015180, HLUNG20020850, HLUNG20029490,
    HLUNG20032460, HLUNG20033350, HLUNG20034970, HLUNG20037160,
    HLUNG20041540, HLUNG20042730, HLUNG20050760, HLUNG20052300,
    HLUNG20060670, HLUNG20065990, HLUNG20074330, HLUNG20081390,
    HLUNG20088750, HLUNG20092530, KIDNE20016360, KIDNE20083150,
    KIDNE20084030, KIDNE20084040, KIDNE20084800, KIDNE20086490,
    KIDNE20086660, KIDNE20094670, KIDNE20134130, KIDNE20142900,
    KIDNE20143200, KIDNE20148080, KIDNE20160960, KIDNE20163710,
    KIDNE20169180, KIDNE20182540, KIDNE20186170, KIDNE20188630,
    KIDNE20189960, LIVER20007750, LIVER20010510, LIVER20010990,
    LIVER20026440, LIVER20030650, LIVER20038000, MESAN20007110,
    MESAN20008150, MESAN20021220, MESAN20027900, MESAN20058110,
    MESAN20059570, MESAN20060430, MESAN20067430, MESAN20084150,
    MESAN20095220, NT2NE20018740, NT2NE20021860, NT2NE20039210,
    NT2NE20053230, NT2NE20059210, NT2NE20064780, NT2NE20069580,
    NT2NE20080770, NT2NE20082130, NT2NE20092950, NT2NE20140130,
    NT2NE20145250, NT2NE20146510, NT2NE20152620, NT2NE20167660,
    NT2NE20181800, NT2RI20016240, NT2RI20021200, NT2RI20033920,
    NT2RP70003110, NT2RP70027790, NT2RP70031070, NT2RP70031480,
    NT2RP70056690, NT2RP70087140, NTONG20034540, NTONG20053630,
    OCBBF20000740, OCBBF20012520, OCBBF20109780, OCBBF20110210,
    OCBBF20110730, OCBBF20112280, OCBBF20118720, OCBBF20120010,
    OCBBF20123200, OCBBF20155030, OCBBF20165900, OCBBF20165910,
    OCBBF20170350, OCBBF20176650, OCBBF20185630, OCBBF20191950,
    PANCR10000860, PEBLM20001800, PLACE50001290, PLACE60004260,
    PLACE60006300, PLACE60053280, PLACE60055590, PLACE60056910,
    PLACE60057860, PLACE60061370, PLACE60064740, PLACE60070500,
    PLACE60087680, PLACE60104630, PLACE60107010, PLACE60113340,
    PLACE60138840, PLACE60154450, PLACE60184870, PROST10001100,
    PROST20011160, PROST20014150, PROST20035830, PROST20045700,
    PROST20050390, PROST20065100, PROST20073280, PROST20082430,
    PROST20084680, PROST20084720, PROST20099090, PROST20105450,
    PROST20106060, PROST20108850, PROST20110120, PROST20114100,
    PROST20146590, PROST20152510, PROST20168600, PUAEN10000870,
    SKMUS20006790, SKMUS20020770, SKMUS20073150, SKMUS20091900,
    SKNMC20006350, SKNSH20094350, SMINT20006090, SMINT20008110,
    SMINT20024140, SMINT20028840, SMINT20045470, SMINT20077960,
    SMINT20081330, SMINT20086250, SMINT20088440, SMINT20088690, SMINT20092160,
    SPLEN20015100, SPLEN20017610, SPLEN20017810, SPLEN20024190,
    SPLEN20024620, SPLEN20054500, SPLEN20058180,
    SPLEN20063890, SPLEN20073880, SPLEN20080070, SPLEN20090880,
    SPLEN20101950, SPLEN20104690, SPLEN20105100, SPLEN20108000,
    SPLEN20110180, SPLEN20110860, SPLEN20118050, SPLEN20121790,
    SPLEN20125230, SPLEN20136700, SPLEN20138600, SPLEN20139100,
    SPLEN20175920, SPLEN20177400, SPLEN20182850, SPLEN20183020,
    SPLEN20183950, SPLEN20190080, SPLEN20190770, SPLEN20193230,
    SPLEN20193490, SPLEN20193790, SPLEN20201830, SPLEN20204670,
    TESOP10000350, TESTI10000190, TESTI20006160, TESTI20029100,
    TESTI20031310, TESTI20032770, TESTI20038240, TESTI20043130,
    TESTI20043220, TESTI20045390, TESTI20046540, TESTI20046870,
    TESTI20047370, TESTI20050400, TESTI20051200, TESTI20051730,
    TESTI20053260, TESTI20053780, TESTI20057200, TESTI20057590,
    TESTI20059080, TESTI20061200, TESTI20062120, TESTI20063330,
    TESTI20063410, TESTI20063600, TESTI20066330, TESTI20068530,
    TESTI20070400, TESTI20070740, TESTI20073460, TESTI20086840,
    TESTI20095200, TESTI20095440, TESTI20095880, TESTI20100090,
    TESTI20102390, TESTI20105910, TESTI20113940, TESTI20116120,
    TESTI20121040, TESTI20121710, TESTI20131440, TESTI20142540,
    TESTI20149880, TESTI20151800, TESTI20162780, TESTI20170170,
    TESTI20173050, TESTI20182760, TESTI20183680, TESTI20184750,
    TESTI20186110, TESTI20198540, TESTI20199110, TESTI20202830,
    TESTI20204260, TESTI20210030, TESTI20214630, TESTI20219110,
    TESTI20244730, TESTI20245600, TESTI20245860, TESTI20246410,
    TESTI20251610, TESTI20257910, TESTI20260640, TESTI20261040,
    TESTI20262150, TESTI20262940, TESTI20264910, TESTI20271790, TESTI20278280,
    TESTI20282420, TESTI20282900, TESTI20286590,
    THYMU20007020, THYMU20012020, THYMU20017270, THYMU20020800,
    THYMU20025480, THYMU20028150, THYMU20030690, THYMU20034790,
    THYMU20046350, THYMU20046770, THYMU20050010, THYMU20052830,
    THYMU20054800, THYMU20055740, THYMU20055760, THYMU20062770,
    THYMU20078240, THYMU20079690, THYMU20083390, THYMU20087270,
    THYMU20100940, THYMU20115380, THYMU20137050, THYMU20137570,
    THYMU20143230, THYMU20150190, THYMU20153210, THYMU20154790,
    THYMU20163600, THYMU20171580, THYMU20178440, THYMU20185470,
    TRACH20011010, TRACH20011540, TRACH20021380, TRACH20073990, TRACH20081270,
    TRACH20090060, TRACH20149720, TRACH20149740, TRACH20159390, TRACH20163470,
    TRACH20165330, TRACH20167090, TRACH20173680, TRACH20190460, UMVEN10001380,
    UTERU20035770, UTERU20040150, UTERU20045200, UTERU20064120, UTERU20086530,
    UTERU20087070, UTERU20087850, UTERU20089300, UTERU20089620, UTERU20095100,
    UTERU20099040, UTERU20103200, UTERU20125810, UTERU20127030, UTERU20127150,
    UTERU20139760, UTERU20188840
  • The clones predicted to belong to the category of glycoprotein-related protein are the following 121 clones.
    ADRGL20020290, ADRGL20036840, ADRGL20059610, ADRGL20066770,
    ASTRO20055570, BNGH420046790, BNGH420077980, BRACE20051930,
    BRACE20069000, BRACE20204670, BRACE20216950, BRAMY20013670,
    BRAMY20089770, BRAMY20251210, BRAWH20039640, BRCAN10000760,
    BRCAN20005230, BRCOC20003600, CD34C20001750, CTONG20017490,
    CTONG20036990, CTONG20045500, CTONG20059130, CTONG20079590, CTONG20085210,
    CTONG20184830, DFNES20018000, DFNES20080880, FCBBF30004340, FCBBF30029250,
    FCBBF30062490, FCBBF30091520, FCBBF30164510, FCBBF30171230, FCBBF30195690,
    FCBBF30223210, FEBRA20038220, HCHON20015050, HLUNG20015070, HLUNG20032460,
    HLUNG20037160, HLUNG20041540, KIDNE20142900, KIDNE20169180,
    KIDNE20186170, KIDNE20189960, MESAN20021220, MESAN20058110,
    NT2NE20064780, NT2NE20140130, NT2NE20155650, NT2RP70056690,
    NTONG20053630, OCBBF20000740, OCBBF20012520, OCBBF20110210,
    OCBBF20120010, OCBBF20165900, OCBBF20165910, OCBBF20191950,
    PEBLM20001800, PLACE60004260, PLACE60087680, PLACE60113340,
    PLACE60184870, PROST20033240, PROST20099090, PROST20108850,
    PROST20146590, SKMUS20073150, SKNMC20006350, SMINT20028840,
    SMINT20056230, SMINT20083290, SMINT20091190, SPLEN20024620,
    SPLEN20063890, SPLEN20080070, SPLEN20090880, SPLEN20118050,
    SPLEN20139100, SPLEN20183020, SPLEN20201830, TESTI10000190,
    TESTI20031310, TESTI20043990, TESTI20045390, TESTI20051200,
    TESTI20057590, TESTI20059080, TESTI20066330, TESTI20086840,
    TESTI20100090, TESTI20105910, TESTI20154370, TESTI20164210,
    TESTI20182760, TESTI20184750, TESTI20199110, TESTI20219110,
    TESTI20220230, TESTI20245600, TESTI20251610, TESTI20257910, TESTI20286590,
    THYMU20024500, THYMU20028150, THYMU20052830, THYMU20062770,
    THYMU20099060, THYMU20170080, THYMU20178440, TRACH20011010, TRACH20011540,
    TRACH20021380, TRACH20149740, TRACH20170860, TRACH20190460, UTERU20086530,
    UTERU20087070, UTERU20127030
  • The clones predicted to belong to the category of signal transduction-related protein are the following 88 clones.
    ASTRO20050810, ASTRO20052420, ASTRO20085080, ASTRO20090680,
    BNGH420008150, BNGH420015760, BNGH420035290, BNGH420086030,
    BRAMY20035830, BRAMY20043630, BRAMY20118490, BRAMY20206340,
    BRAMY20244490, BRAMY20251210, BRAMY20263000, BRAWH20093040,
    BRAWH20190550, CTONG20004520, CTONG20029030, CTONG20030280,
    CTONG20063930, CTONG20070720, CTONG20189000, FCBBF30001100,
    FCBBF30076310, FCBBF30100080, FCBBF30143550, FCBBF30153170,
    FCBBF30175350, FCBBF30250980, FEBRA20090160, FEBRA20173330,
    HCHON20000870, HLUNG20011260, HLUNG20084790, KIDNE20089870,
    KIDNE20160360, LIVER20011640, MESAN20021130, MESAN20027240,
    MESAN20065990, NT2NE20018890, NT2NE20042550, NT2RP70075800,
    NTONG20043080, NTONG20048440, PLACE60071800, PROST20033240,
    PROST20052850, PROST20065790, PROST20075280, SKNSH20052400,
    SKNSH20057920, SMINT20006020, SMINT20035050, SPLEN20023540, SPLEN20039180,
    SPLEN20048800, SPLEN20049840, SPLEN20054160, SPLEN20085910, SPLEN20191020,
    SPLEN20198390, TESTI20046490, TESTI20049060, TESTI20053070, TESTI20066650,
    TESTI20081890, TESTI20095770, TESTI20106820, TESTI20112860, TESTI20145780,
    TESTI20150420, TESTI20168880, TESTI20205250, TESTI20228120, TESTI20244220,
    TESTI20244460, TESTI20251740, TESTI20261160, TESTI20264530, THYMU20013250,
    THYMU20039320, THYMU20106990, THYMU20145990, THYMU20170080,
    THYMU20176010, TRACH20188350
  • The clones predicted to belong to the category of transcription-related protein are the following 143 clones.
    ASTRO20038400, ASTRO20075150, BNGH420070370, BNGH420074600,
    BNGH420087430, BRACE20003310, BRACE20061620, BRAMY20001510,
    BRAMY20040580, BRAMY20076100, BRAMY20111780, BRAWH20040680,
    BRAWH20050740, BRAWH20080580, BRAWH20082920, BRAWH20095900,
    BRSSN20066440, CTONG20020950, CTONG20044230, CTONG20053990,
    CTONG20072930, CTONG20074000, CTONG20084660, CTONG20186370,
    CTONG20186520, DFNES20028170, DFNES20046840, DFNES20073320,
    FCBBF30003610, FCBBF30019140, FCBBF30021900, FCBBF30093170,
    FCBBF30114850, FCBBF30129010, FCBBF30136230, FCBBF30143550,
    FCBBF30220050, FCBBF30228940, FCBBF30263080, FCBBF30285930,
    FCBBF50003530, FEBRA20026820, FEBRA20027070, FEBRA20046510,
    FEBRA20057010, FEBRA20063720, FEBRA20170240, HCHON10000150, HCHON20002650,
    HEART20019310, HLUNG20014590, HLUNG20028110, HLUNG20063700, KIDNE20140870,
    LIVER20006260, MESAN20016270, MESAN20038520, NT2NE20038870, NT2NE20053950,
    NT2NE20060750, NT2NE20061030, NT2NE20079670, NT2NE20082600, NT2RP70001120,
    NT2RP70029780, NT2RP70046410, NT2RP70057500, NT2RP70075300,
    NT2RP70090870, OCBBF20116250, OCBBF20120950, OCBBF20121910,
    OCBBF20156450, OCBBF20157970, OCBBF20166900, OCBBF20175360,
    OCBBF20177540, PEBLM20003260, PLACE60052940, PLACE60066970,
    PLACE60122970, PLACE60150510, PLACE60177880, PROST20007170,
    PROST20024250, PROST20035170, PROST20127450, PROST20151370,
    PROST20155370, PUAEN10000650, PUAEN20003120, SMINT20011950,
    SMINT20026200, SMINT20030740, SMINT20039050, SMINT20044140,
    SMINT20086720, SPLEN20042200, SPLEN20043680, SPLEN20055600,
    SPLEN20059270, SPLEN20063250, SPLEN20098030, SPLEN20197930,
    TESTI10001570, TESTI20057430, TESTI20057840, TESTI20059810,
    TESTI20067480, TESTI20068790, TESTI20075240, TESTI20079220,
    TESTI20088840, TESTI20104090, TESTI20122070, TESTI20166670,
    TESTI20171070, TESTI20173960, TESTI20184760, TESTI20194880,
    TESTI20197600, TESTI20228740, TESTI20254030, TESTI20254990,
    TESTI20266050, TESTI20274960, TESTI20282530, THYMU10004280, THYMU20019260,
    THYMU20032820, THYMU20071120, THYMU20077250, TKIDN10001920, UTERU20016580,
    UTERU20026620, UTERU20041630, UTERU20094830, UTERU20099510, UTERU20101150,
    UTERU20169020, UTERU20177150, UTERU20185220, UTERU20188670
  • The clones predicted to belong to the category of disease-related protein are the following 331 clones.
    ADRGL20020290, ADRGL20021910, ADRGL20026790, ADRGL20036840,
    ADRGL20059610, ADRGL20066770, ASTRO20038400, ASTRO20052420,
    ASTRO20055570, ASTRO20075150, ASTRO20088950, BNGH420008150,
    BNGH420086030, BRACE10000510, BRACE20003310, BRACE20069000,
    BRACE20097540, BRACE20194670, BRACE20196180, BRACE20204670,
    BRACE20216950, BRAMY20003540, BRAMY20005080, BRAMY20035830,
    BRAMY20040580, BRAMY20043630, BRAMY20044920, BRAMY20051820,
    BRAMY20056620, BRAMY20089770, BRAMY20111780, BRAMY20152510,
    BRAMY20190550, BRAMY20221600, BRAMY20227860, BRAMY20274510,
    BRAWH20082920, BRAWH20093040, BRAWH20095900, BRAWH20190530,
    BRAWH20191980, BRCAN10000760, BRCAN10001050, BRCAN20005230,
    BRSSN20066440, CTONG20004520, CTONG20029030, CTONG20042640,
    CTONG20045500, CTONG20052780, CTONG20053990, CTONG20070780,
    CTONG20070910, CTONG20072930, CTONG20083980, CTONG20084660,
    CTONG20165750, CTONG20169040, CTONG20183430, CTONG20183830,
    CTONG20186290, CTONG20189000, DFNES20016470, DFNES20025500,
    DFNES20046840, DFNES20055400, DFNES20080880, FCBBF10000230,
    FCBBF20035490, FCBBF20066340, FCBBF30002270, FCBBF30002280,
    FCBBF30019140, FCBBF30053300, FCBBF30071500, FCBBF30072440,
    FCBBF30076310, FCBBF30080730, FCBBF30100080, FCBBF30115920,
    FCBBF30118670, FCBBF30129010, FCBBF30132050, FCBBF30136230,
    FCBBF30153170, FCBBF30164510, FCBBF30166220, FCBBF30171230,
    FCBBF30175350, FCBBF30194550, FCBBF30220050, FCBBF30223210,
    FCBBF30259050, FCBBF30263080, FCBBF30275590, FCBBF50001650,
    FEBRA20027070, FEBRA20045380, FEBRA20046200, FEBRA20046510,
    FEBRA20057010, FEBRA20063720, FEBRA20078800, FEBRA20087550,
    FEBRA20088810, FEBRA20090160, FEBRA20092760, FEBRA20151750,
    FEBRA20170240, FEBRA20173330, FEBRA20191720, HCHON10000150,
    HCHON20015050, HEART20009590, HEART20022200, HEART20063100,
    HHDPC20081230, HLUNG20008460, HLUNG20014590, HLUNG20032460,
    HLUNG20063700, HLUNG20065990, HLUNG20069350, HLUNG20081530,
    HLUNG20082350, HLUNG20083330, HLUNG20085210, KIDNE20081170,
    KIDNE20084040, KIDNE20088240, KIDNE20089870, KIDNE20133460,
    KIDNE20134890, KIDNE20141700, KIDNE20142900, KIDNE20150730,
    KIDNE20152440, KIDNE20160360, KIDNE20165390, KIDNE20169180,
    KIDNE20173430, KIDNE20189960, LIVER20026440, MESAN20006200,
    MESAN20021130, MESAN20033220, MESAN20056890, MESAN20057240,
    MESAN20065990, MESAN20067430, MESAN20069530, NESOP20004520,
    NT2NE20018890, NT2NE20026200, NT2NE20037050, NT2NE20053950,
    NT2NE20061030, NT2NE20111190, NT2NE20117580, NT2NE20119980,
    NT2NE20140130, NT2NE20141040, NT2RI20093010, NT2RP70003110,
    NT2RP70046410, NT2RP70075300, NTONG20032100, NTONG20034540,
    OCBBF20000740, OCBBF20012520, OCBBF20111600, OCBBF20120010,
    OCBBF20156450, OCBBF20157970, OCBBF20191950, PEBLM20001800,
    PEBLM20003260, PLACE60004260, PLACE60012620, PLACE60054230,
    PLACE60054870, PLACE60062660, PLACE60087680, PLACE60184870,
    PROST20015210, PROST20024250, PROST20036350, PROST20050390,
    PROST20058860, PROST20063430, PROST20065790, PROST20084720,
    PROST20099090, PROST20120070, PROST20127450, PROST20146590,
    PROST20152510, PROST20168600, PUAEN10000650, PUAEN20003120,
    SKMUS20008730, SKMUS20017400, SKMUS20040440, SKMUS20073590,
    SKMUS20079150, SKNSH20009710, SMINT20002320, SMINT20007470,
    SMINT20008110, SMINT20011950, SMINT20016150, SMINT20026200,
    SMINT20030740, SMINT20049920, SMINT20077960, SMINT20083290,
    SMINT20086250, SMINT20089600, SMINT20091190, SPLEN20023540,
    SPLEN20024190, SPLEN20042200, SPLEN20043680, SPLEN20055600,
    SPLEN20057830, SPLEN20059270, SPLEN20063890, SPLEN20073500,
    SPLEN20080070, SPLEN20085910, SPLEN20090880, SPLEN20098030,
    SPLEN20118050, SPLEN20136730, SPLEN20138600, SPLEN20139100,
    SPLEN20139360, SPLEN20180980, SPLEN20187490, SPLEN20193790,
    SPLEN20201830, TESTI10000190, TESTI20031310, TESTI20035790,
    TESTI20041630, TESTI20049060, TESTI20050720, TESTI20051200,
    TESTI20057430, TESTI20057590, TESTI20059080, TESTI20062120,
    TESTI20067480, TESTI20071630, TESTI20099350, TESTI20105130,
    TESTI20105910, TESTI20108060, TESTI20125920, TESTI20130530,
    TESTI20131440, TESTI20134680, TESTI20142540, TESTI20143180,
    TESTI20150420, TESTI20154370, TESTI20164210, TESTI20166670,
    TESTI20168880, TESTI20171070, TESTI20182760, TESTI20184750,
    TESTI20193080, TESTI20194880, TESTI20196970, TESTI20197600,
    TESTI20201760, TESTI20207170, TESTI20219110, TESTI20228740, TESTI20244430,
    TESTI20246480, TESTI20251740, TESTI20252690, TESTI20254030, TESTI20257910,
    TESTI20258720, TESTI20266050, TESTI20271790, TESTI20274960, TESTI20282530,
    TESTI20286590, THYMU10004280, THYMU20006020, THYMU20013250, THYMU20019260,
    THYMU20023560, THYMU20028150, THYMU20032820, THYMU20034400,
    THYMU20055460, THYMU20063650, THYMU20070250, THYMU20071120,
    THYMU20081110, THYMU20090230, THYMU20095920, THYMU20098350,
    THYMU20099060, THYMU20120730, THYMU20121040, THYMU20170080,
    THYMU20185650, THYMU20191970, TKIDN10000620, TKIDN10001920,
    TRACH20011540, TRACH20091070, TRACH20143710, TRACH20170860,
    UTERU10001060, UTERU20026620, UTERU20041630, UTERU20086530, UTERU20087070,
    UTERU20087850, UTERU20099510, UTERU20101150, UTERU20104310, UTERU20127030,
    UTERU20185220
  • In particular, hit data of the following 328 clones for Swiss-Prot, or GenBank, UniGene, or nr corresponded to genes or proteins which had been deposited in the Online Mendelian Inheritance in Man (OMIM), which is the human gene and disease database, (the OMIM Number is shown in the parenthesis after the Clone Name).
    ADRGL20020290 (602193), ADRGL20021910 (605717),
    ADRGL20026790 (605046), ADRGL20036840 (142800),
    ADRGL20059610 (230800; 230900; 231000; 231005), ADRGL20066770
    (130660), ASTRO20038400 (604764), ASTRO20052420 (600888),
    ASTRO20055570 (176640; 123400; 137440; 245300; 600072),
    ASTRO20075150 (601896), ASTRO20088950 (603202; 223000; 223100),
    BNGH420008150 (600050), BNGH420086030 (118423),
    BRACE10000510 (148021), BRACE20003310 (603899),
    BRACE20069000 (204200), BRACE20097540 (604908),
    BRACE20194670 (314375), BRACE20196180 (605535),
    BRACE20204670 (176884), BRACE20216950 (158070),
    BRAMY20003540 (602142), BRAMY20005080 (604735),
    BRAMY20035830 (603524), BRAMY20040580 (604077),
    BRAMY20043630 (602775), BRAMY20044920 (603486),
    BRAMY20051820 (604567), BRAMY20056620 (210210),
    BRAMY20089770 (602566), BRAMY20111780 (604077),
    BRAMY20152510 (176879), BRAMY20190550
    (600051), BRAMY20221600 (605789), BRAMY20227860 (605416),
    BRAMY20274510 (180475), BRAWH20082920 (603246),
    BRAWH20093040 (602989), BRAWH20095900 (602277),
    BRAWH20190530 (605208), BRAWH20191980 (239500),
    BRCAN10000760 (111000), BRCAN10001050
    (603696), BRCAN20005230 (603268), BRSSN20066440 (603430),
    CTONG20004520 (603817), CTONG20029030 (602775),
    CTONG20042640 (103390), CTONG20045500 (106195),
    CTONG20052780 (605612), CTONG20053990 (602187),
    CTONG20070780 (118990), CTONG20070910 (604450),
    CTONG20072930 (314995), CTONG20083980 (601703),
    CTONG20084660 (600834), CTONG20165750 (182465),
    CTONG20169040 (148030), CTONG20183430 (106410),
    CTONG20183830 (600382), CTONG20186290 (100660),
    CTONG20189000 (600888), DFNES20016470 (605952),
    DFNES20025500 (604581), DFNES20046840 (602617; 241850),
    DFNES20055400 (603456), DFNES20080880 (602273),
    FCBBF10000230 (602327), FCBBF20035490 (602489),
    FCBBF20066340 (603560), FCBBF30002270 (142708),
    FCBBF30002280 (176763), FCBBF30019140
    (602120), FCBBF30053300 (600299), FCBBF30071500 (125485),
    FCBBF30072440 (604455), FCBBF30076310 (176892), FCBBF30080730
    (600572), FCBBF30100080 (602488), FCBBF30115920 (603577),
    FCBBF30118670 (603640), FCBBF30129010 (601260), FCBBF30132050
    (603018), FCBBF30136230 (189909), FCBBF30153170 (171860;
    171850), FCBBF30164510 (603006), FCBBF30166220 (182144),
    FCBBF30171230 (162151), FCBBF30175350 (602521), FCBBF30194550
    (182900), FCBBF30220050 (600380), FCBBF30223210 (300022),
    FCBBF30263080 (194558), FCBBF30275590 (601403), FCBBF50001650
    (605268), FEBRA20027070 (314995), FEBRA20045380 (602942),
    FEBRA20046200 (106410), FEBRA20046510 (604077),
    FEBRA20057010 (602187), FEBRA20063720 (603899),
    FEBRA20078800 (601825; 256000), FEBRA20087550 (600811),
    FEBRA20088810 (603725), FEBRA20090160
    (600137), FEBRA20092760 (602567), FEBRA20170240 (314997),
    FEBRA20173330 (602990), FEBRA20191720 (603895),
    HCHON10000150 (300163), HCHON20015050 (151510),
    HEART20009590 (604581), HEART20022200 (601870),
    HEART20063100 (602422), HHDPC20081230
    (164035), HLUNG20008460 (300108), HLUNG20014590 (604077),
    HLUNG20032460 (176785), HLUNG20063700 (600210),
    HLUNG20065990 (186591), HLUNG20069350 (114212),
    HLUNG20081530 (162230), HLUNG20082350 (604677),
    HLUNG20083330 (120180), HLUNG20085210 (604464),
    KIDNE20081170 (604535), KIDNE20084040 (602382), KIDNE20088240
    (605084), KIDNE20089870 (602922), KIDNE20133460 (605430),
    KIDNE20134890 (117143), KIDNE20141700 (312760), KIDNE20142900
    (188040), KIDNE20150730 (179715), KIDNE20152440 (602194),
    KIDNE20160360 (602488), KIDNE20165390 (604649), KIDNE20169180
    (191845), KIDNE20173430 (603831), KIDNE20189960 (275360),
    LIVER20026440 (601270), MESAN20006200 (151740),
    MESAN20021130 (600050), MESAN20033220 (600466),
    MESAN20056890 (600813), MESAN20057240 (126380),
    MESAN20065990 (601959), MESAN20067430 (191010),
    MESAN20069530 (604362), NESOP20004520 (153432),
    NT2NE20018890 (606031), NT2NE20026200 (277730),
    NT2NE20037050 (300028), NT2NE20053950 (604078),
    NT2NE20061030 (600834), NT2NE20111190 (602619),
    NT2NE20117580 (601825; 256000), NT2NE20119980
    (191161), NT2NE20140130 (601281), NT2NE20141040 (602917),
    NT2RI20093010 (172460), NT2RP70003110 (130160; 194050),
    NT2RP70046410 (601930), NT2RP70075300 (601856),
    NTONG20032100 (148065; 193900), NTONG20034540 (602658),
    OCBBF20000740 (602059), OCBBF20012520 (602059),
    OCBBF20111600 (147625), OCBBF20120010 (605008),
    OCBBF20156450 (314997), OCBBF20157970 (604077),
    OCBBF20191950 (192977), PEBLM20001800 (146900),
    PEBLM20003260 (194558), PLACE60004260 (601891),
    PLACE60012620 (214500), PLACE60054230 (300108),
    PLACE60054870 (160776), PLACE60062660 (606004),
    PLACE60087680 (146732), PLACE60184870 (172425),
    PROST20015210 (160745), PROST20024250 (604078),
    PROST20036350 (138295), PROST20050390 (601258),
    PROST20058860 (182282), PROST20063430 (603292),
    PROST20065790 (171840), PROST20084720 (604426),
    PROST20099090 (602714), PROST20120070 (602809), PROST20127450
    (602960), PROST20146590 (158340; 113720), PROST20152510
    (603367), PROST20168600 (604415), PUAEN10000650 (602960),
    PUAEN20003120 (601573), SKMUS20008730 (602127),
    SKMUS20017400 (191030), SKMUS20040440 (604163),
    SKMUS20073590 (605834), SKMUS20079150 (605596),
    SKNSH20009710 (191030; 164970), SMINT20002320 (601644),
    SMINT20007470 (190370), SMINT20008110 (604384), SMINT20011950
    (603430), SMINT20016150 (134790), SMINT20026200 (159556),
    SMINT20030740 (604078), SMINT20049920 (600417), SMINT20077960
    (137350; 105120), SMINT20083290 (146900), SMINT20086250
    (238330), SMINT20089600 (605926), SMINT20091190 (146900),
    SPLEN20023540 (605577), SPLEN20024190 (601548), SPLEN20042200
    (604167),
    SPLEN20043680 (126340; 234050; 278730), SPLEN20055600 (194541),
    SPLEN20057830 (179715), SPLEN20059270 (602165), SPLEN20063890
    (600245), SPLEN20073500 (603300), SPLEN20080070 (230000),
    SPLEN20085910 (603424), SPLEN20090880 (142800), SPLEN20098030
    (601742), SPLEN20118050 (301870), SPLEN20136730 (605412),
    SPLEN20138600 (603728), SPLEN20139100 (147120), SPLEN20139360
    (117140), SPLEN20180980 (156560), SPLEN20187490 (179838),
    SPLEN20193790 (147150), SPLEN20201830 (301870), TESTI10000190
    (158340; 113720), TESTI20031310 (107280),
    TESTI20035790 (601940), TESTI20049060
    (603889), TESTI20050720 (245050), TESTI20051200 (602273),
    TESTI20057430 (194532), TESTI20057590 (601890), TESTI20059080
    (604038), TESTI20062120 (604212), TESTI20067480 (602277),
    TESTI20071630 (602692), TESTI20099350 (160776), TESTI20105130
    (310400), TESTI20105910 (601328), TESTI20108060 (600590),
    TESTI20125920 (601934), TESTI20130530 (146680), TESTI20131440
    (114850), TESTI20134680 (117143), TESTI20142540 (137960),
    TESTI20143180 (117143), TESTI20150420 (602732), TESTI20154370
    (600936), TESTI20164210 (602319), TESTI20166670 (142968),
    TESTI20168880 (151410), TESTI20171070 (604064), TESTI20182760
    (601328), TESTI20184750 (150320), TESTI20193080 (602128),
    TESTI20194880 (602260), TESTI20196970 (601117), TESTI20197600
    (604167), TESTI20201760 (602162), TESTI20207170 (480100),
    TESTI20219110 (601890), TESTI20228740 (604077), TESTI20244430
    (182900), TESTI20246480 (601486), TESTI20251740 (602731),
    TESTI20252690 (601368), TESTI20254030 (602330), TESTI20257910
    (142871), TESTI20258720 (182900), TESTI20266050 (109092),
    TESTI20271790 (604678), TESTI20274960 (194558), TESTI20282530
    (604077), TESTI20286590 (147267), THYMU10004280 (602290),
    THYMU20006020 (601149), THYMU20013250 (601988),
    THYMU20019260 (603899), THYMU20023560 (142765),
    THYMU20028150 (190197), THYMU20032820 (604077),
    THYMU20034400 (604449), THYMU20055460 (133280),
    THYMU20063650 (180480), THYMU20070250 (277730),
    THYMU20071120 (603899), THYMU20081110 (602567),
    THYMU20090230 (602324), THYMU20095920 (605349),
    THYMU20098350 (148040; 131760; 131800; 131900),
    THYMU20099060 (146900), THYMU20120730 (100660),
    THYMU20121040 (130592), THYMU20170080 (604964),
    THYMU20185650 (602121; 124900), THYMU20191970 (604265),
    TKIDN10000620 (605072), TKIDN10001920 (603899),
    TRACH20011540 (191155), TRACH20091070 (100660),
    TRACH20143710 (601905), TRACH20170860 (147170),
    UTERU10001060 (311040), UTERU20026620 (314997),
    UTERU20041630 (602277), UTERU20086530 (173310),
    UTERU20087070 (216950), UTERU20087850 (605248),
    UTERU20099510 (604077), UTERU20101150 (164012),
    UTERU20104310 (604414), UTERU20127030 (150325),
    UTERU20185220 (600014)
  • The clones predicted to belong to the category of enzyme and/or metabolism-related protein are the following 219 clones.
    ADRGL20059610, ASTRO20026320, ASTRO20050810,
    ASTRO20088950, BNGH420008150, BNGH420035290,
    BNGH420074600, BRACE20050870, BRACE20097540,
    BRACE20200770, BRACE20204670, BRACE20215410,
    BRAMY20003540, BRAMY20005080, BRAMY20027990,
    BRAMY20028620, BRAMY20044920, BRAMY20055760,
    BRAMY20056620, BRAMY20072870, BRAMY20093490,
    BRAMY20096930, BRAMY20118490, BRAMY20125360,
    BRAMY20143870, BRAMY20152510, BRAMY20231150,
    BRAMY20244490, BRAMY20251210, BRAWH20021910,
    BRAWH20082920, BRAWH20093040, BRAWH20094900,
    BRAWH20183170, BRAWH20188750, BRAWH20190550,
    BRAWH20191980, BRCAN20005230, BRCOC20003600,
    CTONG20051100, CTONG20070910, CTONG20076810,
    CTONG20079590, CTONG20080140, CTONG20085210,
    CTONG20186290, DFNES20063460, DFNES20080880,
    FCBBF20023490, FCBBF20066340, FCBBF30004340, FCBBF30019140,
    FCBBF30022680, FCBBF30029250, FCBBF30072440, FCBBF30076310,
    FCBBF30085560, FCBBF30091520, FCBBF30107290, FCBBF30125880,
    FCBBF30132050, FCBBF30143550, FCBBF30153170, FCBBF30166220,
    FCBBF30171230, FCBBF30175350, FCBBF30236670, FCBBF30260480,
    FEBRA20038220, FEBRA20040560, FEBRA20078800,
    FEBRA20090160, FEBRA20172230, FEBRA20173330,
    HCHON20000870, HCHON20002710, HEART10001490,
    HEART20022200, HEART20047640, HEART20082570,
    HLUNG20011260, HLUNG20032460, HLUNG20041540,
    HLUNG20042730, HLUNG20054790, KIDNE20080690,
    KIDNE20083620, KIDNE20084040, KIDNE20147170,
    KIDNE20152440, KIDNE20173150, KIDNE20186170,
    KIDNE20189960, LIVER20011640, LIVER20026440, LIVER20055270,
    MESAN20021130, MESAN20033220, MESAN20038520,
    MESAN20057240, MESAN20058110, MESAN20065990,
    MESAN20095800, NT2NE20026200, NT2NE20042550,
    NT2NE20117580, NT2NE20127900, NT2RI20093010,
    NT2RP70064570, NTONG20034540, NTONG20043080,
    NTONG20053630, NTONG20053730, NTONG20058010,
    OCBBF20120010, OCBBF20167290, OCBBF20191950,
    PANCR10000860, PLACE60052940, PLACE60064180,
    PLACE60073090, PLACE60095600, PLACE60184410,
    PLACE60188630, PROST20007600, PROST20033240,
    PROST20036350, PROST20039300, PROST20050390,
    PROST20051310, PROST20052850, PROST20065790,
    PROST20075280, PROST20084720, PROST20099090, PROST20108850,
    PROST20152510, PUAEN20001520, PUAEN20002470,
    SKNMC20006350, SKNSH20057920, SMINT20008110,
    SMINT20049920, SMINT20094680, SPLEN20023540,
    SPLEN20024930, SPLEN20043680, SPLEN20048800,
    SPLEN20054500, SPLEN20057900, SPLEN20071820, SPLEN20080070,
    SPLEN20085910, SPLEN20108000, SPLEN20136730, SPLEN20180980,
    TESTI20012080, TESTI20030200, TESTI20031310, TESTI20038240,
    TESTI20050720, TESTI20051200, TESTI20059080, TESTI20062120,
    TESTI20066330, TESTI20076570, TESTI20103690, TESTI20105130,
    TESTI20106820, TESTI20108060, TESTI20112860, TESTI20121040,
    TESTI20130530, TESTI20131440, TESTI20168880, TESTI20170170,
    TESTI20196690, TESTI20196970, TESTI20199110, TESTI20205250,
    TESTI20212970, TESTI20222030, TESTI20226520, TESTI20227380,
    TESTI20244460, TESTI20244730, TESTI20250630, TESTI20260640,
    TESTI20262940, TESTI20264530, TESTI20285230, THYMU20006020,
    THYMU20013250, THYMU20034400, THYMU20039320,
    THYMU20055460, THYMU20055760, THYMU20063650,
    THYMU20066660, THYMU20070250, THYMU20087270,
    THYMU20096580, THYMU20100940, THYMU20110720,
    THYMU20120240, THYMU20120730, THYMU20170230,
    TRACH20011010, TRACH20021380, TRACH20091070,
    TRACH20113020, TRACH20143710, TRACH20164100,
    TRACH20190460, UTERU20087070, UTERU20089620,
    UTERU20104310, UTERU20185220, UTERU20188670
  • The clones predicted to belong to the category of cell division and/or cell proliferation-related protein are the following 44 clones.
    ASTRO20090680, BRACE20079370, BRAMY20234820,
    BRCAN10001050, BRCAN20005410, CTONG20032930,
    FCBBF20070950, FCBBF30002270, FCBBF30053300,
    FCBBF30105860, FCBBF30175350, FCBBF30215240,
    FCBBF30275590, FEBRA20045380, HLUNG20068120,
    KIDNE20134890, KIDNE20150730, MESAN20021470,
    NT2NE20077250, NT2NE20153620, NT2RP70030840,
    NTONG20053910, OCBBF20111370, OCBBF20174580,
    PROST20063430, SKNMC10001230, SMINT20028800,
    SPLEN20023540, SPLEN20057830, SPLEN20139360,
    TESTI20031410, TESTI20057840, TESTI20065650, TESTI20066650,
    TESTI20107320, TESTI20108060, TESTI20114480, TESTI20134680,
    TESTI20143180, TESTI20150920, TESTI20201760, TESTI20278280,
    TESTI20284260, THYMU20097920
  • The clones predicted to belong to the category of cytoskeleton-related protein are the following 80 clones.
    ADRGL20062330, ASTRO20053430, BGGI120000670,
    BRACE20079370, BRAMY20038980, BRAMY20083330,
    BRAMY20094890, CTONG20004110, CTONG20032930,
    CTONG20077760, CTONG20083980, CTONG20169040,
    CTONG20183430, DFNES20018000, FCBBF30105860,
    FCBBF30130410, FCBBF30194550, FCBBF30201630,
    FCBBF30271990, FEBRA20005040, FEBRA20046200,
    FEBRA20099860, HCHON20015050, HLUNG20081530,
    KIDNE20081170, NT2RP70001730, NT2RP70003110,
    NTONG20032100, OCBBF20166890, OCBBF20174890,
    PLACE60054870, PLACE60055590, PLACE60071800,
    PLACE60118810, PROST20015210, PROST20097840,
    PROST20120070, PROST20146590, SKMUS20007260,
    SKMUS20008730, SKMUS20017400, SKMUS20073590,
    SMINT20062050, SMINT20074330, SMINT20077960,
    SPLEN20039180, SPLEN20049840, SPLEN20076470,
    SPLEN20182990, SPLEN20187490, SPLEN20195710, TESTI10000190,
    TESTI20041630, TESTI20057880, TESTI20058920, TESTI20060080,
    TESTI20064530, TESTI20064650, TESTI20065650, TESTI20067440,
    TESTI20071130, TESTI20099350, TESTI20112540, TESTI20125280,
    TESTI20136010, TESTI20153310, TESTI20175370, TESTI20222460,
    TESTI20244430, TESTI20254030, TESTI20258720, THYMU20024500,
    THYMU20062610, THYMU20098350, TRACH20043360,
    TRACH20098510, TRACH20149500, UTERU20089390,
    UTERU20122520, UTERU20168960
  • The clones predicted to belong to the category of nuclear protein and/or RNA synthesis-related protein are the following 70 clones.
    ASTRO20026320, BRACE20050870, BRACE20200770,
    BRAMY20134050, BRAWH20063010, BRAWH20093040,
    BRAWH20174330, BRAWH20176850, CTONG20042640,
    FCBBF20023490, FCBBF20035490, FCBBF20070950,
    FCBBF30002270, FCBBF30048420, FCBBF30080730,
    FCBBF30115920, FCBBF30236670, FEBRA20035240,
    FEBRA20092760, FEBRA20173330, HHDPC20081230,
    HLUNG20011460, HLUNG20068120, KIDNE20089870,
    KIDNE20150730, MESAN20056890, MESAN20057240,
    NT2NE20037050, NT2NE20167660, NT2RP70031070,
    NTONG20053730, PLACE60064180, PLACE60095600,
    PROST20016760, PROST20051310, PROST20058860, PROST20152510,
    PUAEN20002470, SKMUS20079150, SKNSH20030640,
    SPLEN20023850, SPLEN20057830, SPLEN20139360, SPLEN20190430,
    TESTI20006830, TESTI20030200, TESTI20031410, TESTI20035790,
    TESTI20062120, TESTI20065650, TESTI20081890, TESTI20150920,
    TESTI20153310, TESTI20201760, TESTI20212970, TESTI20227380,
    TESTI20251740, TESTI20256560, TESTI20260640, TESTI20270130,
    TESTI20284260, TESTI20285230, THYMU20021090,
    THYMU20049060, THYMU20066660, THYMU20081110,
    THYMU20090230, THYMU20120240,
    UTERU10001060, UTERU20104310
  • The clones predicted to belong to the category of protein synthesis and/or transport-related protein are the following 20 clones.
    BRAMY20038980, BRAMY20274510, CTONG20008190,
    CTONG20033610, FCBBF20018680, FEBRA20090220,
    KIDNE20141700, NT2NE20167660, NTONG20055200,
    PLACE60012620, PROST20036350, PROST20062820,
    SKMUS20040440, SMINT20000070, SPLEN20180980,
    TESTI20055680, TESTI20067440, TESTI20107240,
    THYMU20096580, THYMU20121040
  • The clones predicted to belong to the category of cellular defense-related protein are the following 10 clones.
    ASTRO20089600, BRAMY20117670, FEBRA20087550,
    HLUNG20081390, MESAN20057240, NTONG20031580,
    PROST20007600, SPLEN20023850, SPLEN20043680, TESTI20261680
  • The clones predicted to belong to the category of development and/or differentiation-related protein are the following 19 clones.
    BRACE20061620, BRACE20200770, BRAMY20013670,
    CTONG20017490, CTONG20020950, HCHON10000150,
    MESAN20021470, OCBBF20165910, PROST20155370,
    PUAEN20002470, TESTI20079220, TESTI20079980,
    TESTI20166670, TESTI20184760, TESTI20252690, TRACH20040390,
    UTERU20089620, UTERU20094830, UTERU20169020
  • The clones predicted to belong to the category of DNA-binding and/or RNA-binding protein are the following 168 clones.
    ASTRO20038400, BGGI120010750, BNGH420070370,
    BRACE20003310, BRACE20061620, BRAMY20001510,
    BRAMY20040580, BRAMY20076100, BRAMY20111780,
    BRAMY20274510, BRAWH20040680, BRAWH20050740,
    BRAWH20063010, BRAWH20080580, BRAWH20095900,
    BRAWH20174330, BRSSN20066440, CTONG20020950,
    CTONG20044230, CTONG20053990, CTONG20072930,
    CTONG20074000, CTONG20165750, CTONG20186370,
    CTONG20186520, DFNES20046840, DFNES20073320,
    FCBBF20035430, FCBBF20070950, FCBBF30002270,
    FCBBF30003610, FCBBF30019140, FCBBF30021900,
    FCBBF30048420, FCBBF30080730, FCBBF30093170,
    FCBBF30114850, FCBBF30129010, FCBBF30136230,
    FCBBF30220050, FCBBF30228940, FCBBF30236670,
    FCBBF30263080, FCBBF30285930, FCBBF50003530,
    FEBRA20026820, FEBRA20027070, FEBRA20035240,
    FEBRA20046510, FEBRA20057010, FEBRA20063720,
    FEBRA20087550, FEBRA20092760, FEBRA20170240,
    FEBRA20177800, HCHON20002650, HEART20019310,
    HEART20063100, HHDPC20081230, HLUNG20011460,
    HLUNG20014590, HLUNG20028110, HLUNG20063700,
    HLUNG20068120, KIDNE20140870, LIVER20006260,
    MESAN20016270, MESAN20056890, MESAN20057240,
    NT2NE20038870, NT2NE20053950, NT2NE20060750,
    NT2NE20079670, NT2NE20082600, NT2NE20087270,
    NT2RP70029780, NT2RP70046410, NT2RP70057500,
    NT2RP70075300, NT2RP70090870, OCBBF20116250,
    OCBBF20120950, OCBBF20121910, OCBBF20156450,
    OCBBF20157970, OCBBF20166900, OCBBF20175360,
    OCBBF20177540, PEBLM10001470, PEBLM20003260,
    PLACE60066970, PLACE60122970, PLACE60177880,
    PROST20007170, PROST20024250, PROST20035170,
    PROST20051310, PROST20058860, PROST20151370,
    PROST20155370, PUAEN20003120, SMINT20011950,
    SMINT20030740, SMINT20039050, SMINT20044140,
    SMINT20086720, SPLEN20042200, SPLEN20043680,
    SPLEN20055600, SPLEN20059270, SPLEN20063250,
    SPLEN20139360, SPLEN20190430, TESTI10001570,
    TESTI20006830, TESTI20030200, TESTI20031410,
    TESTI20035790, TESTI20057430, TESTI20059810,
    TESTI20062120, TESTI20067480, TESTI20068790,
    TESTI20075240, TESTI20079220, TESTI20088840, TESTI20104090,
    TESTI20134970, TESTI20166670, TESTI20171070, TESTI20173960,
    TESTI20184760, TESTI20197600, TESTI20201760, TESTI20212970,
    TESTI20227380, TESTI20228740, TESTI20246480, TESTI20254030,
    TESTI20254990, TESTI20266050, TESTI20268240, TESTI20270130,
    TESTI20274960, TESTI20282530, TESTI20284260, TESTI20285230,
    THYMU10004280, THYMU20019260, THYMU20023560,
    THYMU20032820, THYMU20049060, THYMU20066660,
    THYMU20071120, THYMU20077250, THYMU20081110,
    THYMU20090230, TKIDN10001920, TRACH20108240,
    UTERU10001060, UTERU20026620, UTERU20041630,
    UTERU20094830, UTERU20099510, UTERU20101150,
    UTERU20169020, UTERU20177150, UTERU20188670
  • The clones predicted to belong to the category of ATP binding and/or GTP-binding protein are the following 93 clones.
    ASTRO20026320, BNGH420035290, BRACE20050870,
    BRACE20079370, BRACE20200770, BRAMY20055760,
    BRAMY20118490, BRAMY20244490, BRAMY20251210,
    BRAWH20093040, BRAWH20190550, BRCAN10001050,
    BRCOC20003600, CTONG20008190, CTONG20030280,
    CTONG20032930, CTONG20176040, CTONG20184830,
    FCBBF20023490, FCBBF30019140, FCBBF30076310,
    FCBBF30105860, FCBBF30175350, FCBBF30201630,
    FCBBF30236670, FEBRA20005040, FEBRA20090160,
    FEBRA20173330, HCHON20000870, HLUNG20011260,
    HLUNG20052300, KIDNE20081170, KIDNE20134890,
    LIVER20030650, LIVER20055270, MESAN20065990,
    NT2NE20042550, NTONG20043080, NTONG20055200,
    OCBBF20182060, PLACE60054870, PLACE60064180,
    PLACE60095600, PLACE60140640, PROST20015210,
    PROST20033240, PROST20036350, PROST20051310,
    PROST20052850, PROST20062820, PROST20075280, PROST20120070,
    PUAEN20002470, SKNSH20052400, SKNSH20057920,
    SMINT20008110, SPLEN20023850, SPLEN20043680, SPLEN20049840,
    SPLEN20136730, SPLEN20180980, SPLEN20193790, TESTI20055680,
    TESTI20058920, TESTI20060080, TESTI20064650, TESTI20071130,
    TESTI20099350, TESTI20106820, TESTI20112860, TESTI20134680,
    TESTI20136010, TESTI20143180, TESTI20175370, TESTI20212970,
    TESTI20222460, TESTI20227380, TESTI20244220, TESTI20244460,
    TESTI20264530, THYMU20013250, THYMU20039320,
    THYMU20062610, THYMU20066660, THYMU20087270,
    THYMU20096580, THYMU20100940, THYMU20176010,
    TRACH20043360, TRACH20098510, TRACH20113020,
    UTERU20185220, UTERU20188670
  • Among the clones other than the ones shown above, BNGH420036410 and FCBBF30257370 are clones which were predicted to highly possibly belong to the category of secretory protein and/or membrane protein based on the result of domain search by Pfam.
  • SMINT20044730, TESTI20140970
  • The two clones shown above are clones which were predicted to highly possibly belong to the category of glycoprotein-related protein based on the result of domain search by Pfam.
    BRACE20055560, CTONG20046690, DFNES20043710,
    FCBBF30005500, MESAN20030350, MESAN20030370,
    PLACE60074820, TESTI20058350, TESTI2010E170,
    TRACH20131230, UTERU20000950
  • The 11 clones shown above are clones which were predicted to highly possibly belong to the category of signal transduction-related protein based on the result of domain search by Pfam.
    ASTRO20010290, BRACE20099070, CTONG20007660,
    DFNES20076340, DFNES20094820, FCBBF30125460,
    FCBBF30142290, FCBBF30169280, FEBRA20031000,
    NT2NE20026510, NT2RP70031340, PLACE50001390,
    SPLEN20135030, TESTI20046890, TESTI20060350,
    TESTI20166290, TESTI20259110, THYMU20184550
  • The 18 clones shown above are clones which were predicted to highly possibly belong to the category of transcription-related protein based on the result of domain search by Pfam.
    ADRGL20047770, ADRGL20079060, BRACE20014450,
    BRACE20051600, BRAWH20185260, CTONG20033750,
    CTONG20070090, CTONG20190290, FCBBF20020440,
    FCBBF30005360, FCBBF30173960, FEBRA20031000,
    KIDNE20087880, LIVER20013890, MESAN20030350,
    MESAN20030370, OCBBF20113110, PLACE60074820,
    PLACE60093380, PROST20028970, PROST20102190,
    SALGL10001070, SPLEN20006950, SPLEN20011350,
    SPLEN20050090, TESTI20060830, TESTI20066150,
    TESTI20120900, TESTI20132310, TESTI20148380,
    TESTI20162980, TESTI20166290, TESTI20205100,
    THYMU20112590, TRACH20029880
  • The 35 clones shown above are clones which were predicted to highly possibly belong to the category of enzyme and/or metabolism-related protein based on the result of domain search by Pfam.
  • PLACE60054820, TESTI20197030
  • The two clones shown above are clones which were predicted to highly possibly belong to the category of cell division and/or cell proliferation-related protein based on the result of domain search by Pfam.
  • ASTRO20006530, OCBBF20016390, TRACH20058000
  • The three clones shown above are clones which were predicted to highly possibly belong to the category of cytoskeleton-related protein based on the result of domain search by Pfam.
  • BRACE20065470, PLACE60054820
  • The two clones shown above are clones which were predicted to highly possibly belong to the category of nuclear protein and/or RNA synthesis-related protein based on the result of domain search by Pfam.
    ASTRO20010290, BRACE20099070, BRAWH20014590,
    CTONG20007660, DFNES20076340, DFNES20094820,
    FCBBF30125460, FCBBF30142290, FCBBF30169280,
    FEBRA20031000, MESAN20034440, NT2NE20026510,
    NT2RP70031340, PLACE50001390, SPLEN20135030,
    TESTI20046890, TESTI20060350, TESTI20166290,
    TESTI20259110, THYMU20104480, THYMU20184550
  • The 21 clones shown above are clones which were predicted to highly possibly belong to the category of DNA-binding and/or RNA-binding protein based on the result of domain search by Pfam.
  • KIDNE20133880, MESAN20030350, MESAN20030370, TESTI20059480
  • The four clones shown above are clones which were predicted to highly possibly belong to the category of ATP-binding and/or GTP-binding protein based on the result of domain search by Pfam.
  • The 205 clones shown below are clones which were unassignable to any of the above-mentioned categories, but have been predicted to have some functions based on homology search for their full-length nucleotide sequences and motif search in their deduced ORFs. Clone Name, Definition in the result of homology search or Motif Name in the motif search, demarcated by a double slash mark (//), are shown below.
    • ADRGL20022600//DIAPHANOUS PROTEIN HOMOLOG 1 (P140MDIA).
    • ADRGL20023920//ABC1 PROTEIN HOMOLOG PRECURSOR.
    • ASTRO20001910//Rattus norvegicus mRNA for annexin V-binding protein (ABP-10), partial cds.
    • ASTRO20009140//PUTATIVE COMPETENCE-DAMAGE PROTEIN.
    • ASTRO20046280//PSU1 PROTEIN.
    • ASTRO20058960//DNA damage inducible protein homolog—fission yeast (Schizosaccharomyces pombe)
    • BNGH420024870//C2 domain//C2 domain//C2 domain
    • BRACE20007330//RING CANAL PROTEIN (KELCH PROTEIN).
    • BRACE20052430//Homo sapiens AMSH mRNA, complete cds.
    • BRACE20054600//Xenopus laevis mRNA for Kielin, complete cds.
    • BRACE20059810//TSC-22/dip/bun family
    • BRACE20063540//MEROZOITE SURFACE PROTEIN CMZ-8 (FRAGMENT).
    • BRACE20079200//Xenopus laevis mRNA for Kielin, complete cds.
    • BRAMY20016780//Proprotein convertase P-domain
    • BRAMY20023640//UBX domain
    • BRAMY20045420//Domain found in Dishevelled, Egl-10, and Pleckstrin
    • BRAMY20056840//UBE-1c2
    • BRAMY20063750//Homo sapiens HRIHFB2007 mRNA, partial cds.
    • BRAMY20102900//Homo sapiens RU1 (RU1) mRNA, complete cds.
    • BRAMY20158550//CALMODULIN.
    • BRAMY20223010//Mus musculus leucine-rich glioma-inactivated 1 protein precursor, (Lgi1) mRNA, complete cds.
    • BRAMY20238630//TETRATRICOPEPTIDE REPEAT PROTEIN 4.
    • BRAMY20245760//Araneus diadematus fibroin-4 mRNA, partial cds.
    • BRAWH20047790//HMG (high mobility group) box
    • BRSSN20005610//Mus musculus semaphorin cytoplasmic domain-associated protein 3A (Semcap3) mRNA, complete cds.
    • BRSSN20005660//Bacterial type II secretion system protein
    • BRSSN20093890//Homo sapiens mRNA for Kelch motif containing protein, complete cds.
    • CTONG20041150//Streptomyces ansochromogenes strain 7100 SanE (sanE) gene, complete cds.
    • CTONG20066110//Homo sapiens DEME-6 mRNA, partial cds.
    • CTONG20069420//Ribosomal protein S14p/S29e
    • CTONG20071040//BETA CRYSTALLIN B2 (BP).
    • CTONG20074170//DENN (AEX-3) domain
    • CTONG20083430//Nuclear transition protein 2
    • CTONG20170940//MYOTROPHIN (V-1 PROTEIN) (GRANULE CELL DIFFERENTIATION PROTEIN).
    • CTONG20174290//TRICHOHYALIN.
    • CTONG20174580//Homo sapiens mRNA for vascular Rab-GAP/TBC-containing protein complete cds.
    • CTONG20180690//Collagen triple helix repeat (20 copies)
    • CTONG20186550//cca3 protein—rat
    • CTONG20188080//TPR Domain
    • FCBBF10004760//Homo sapiens GAP-like protein (N61) mRNA, complete cds.
    • FCBBF20033360//RING CANAL PROTEIN (KELCH PROTEIN).
    • FCBBF20041380//SAM domain (Sterile alpha motif)
    • FCBBF20043730//UBA domain
    • FCBBF20056580//Mus musculus NSD1 protein mRNA, complete cds.
    • FCBBF20059660//TPR Domain
    • FCBBF30019180//SERINE/THREONINE PROTEIN PHOSPHATASE 2A, 65 KDA REGULATORY SUBUNIT A, ALPHA ISOFORM (PP2A, SUBUNIT A, PR65-ALPHA ISOFORM) (PP2A, SUBUNIT A, R1-ALPHA ISOFORM).
    • FCBBF30026580//Homo sapiens retinoblastoma-associated protein RAP140 mRNA, complete cds.
    • FCBBF30035570//C2 domain
    • FCBBF30079770//D-isomer specific 2-hydroxyacid dehydrogenases
    • FCBBF30100120//Mus musculus semaphorin cytoplasmic domain-associated protein 3A (Semcap3) mRNA, complete cds.
    • FCBBF30100410//Mus musculus testis-specific Y-encoded-like protein (Tspyl1) mRNA, complete cds.
    • FCBBF30118890//Drosophila melanogaster La related protein (larp) mRNA, partial cds.
    • FCBBF30138000//trg protein—rat
    • FCBBF30157270//Rattus norvegicus PAPIN mRNA, complete cds.
    • FCBBF30161780//gag gene protein p24 (core nucleocapsid protein)//Zinc knuckle
    • FCBBF30198670//dof protein—fruit fly (Drosophila melanogaster)
    • FCBBF30222910//Mus musculus Rap2 interacting protein 8 (RPIP8) mRNA, complete cds.
    • FCBBF30255680//Rattus norvegicus brain specific cortactin-binding protein CBP90 mRNA, partial cds.
    • FCBBF30260210//Drosophila melanogaster KISMET-L long isoform (kis) mRNA, complete cds.
    • FCBBF30282020//cca3 protein—rat
    • FCBBF40000610//late gestation lung 2 protein [Rattus norvegicus].
    • FEBRA20029620//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat
    • FEBRA20031150//Homo sapiens HSKM-B (HSKM-B) mRNA, complete cds.
    • FEBRA20038330//Corticotropin-releasing factor family
    • FEBRA20038970//Homo sapiens mRNA for stabilin-1 (stab1 gene).
    • FEBRA20088610//CELLULAR RETINALDEHYDE-BINDING PROTEIN (CRALBP).
    • FEBRA20150420//HYPOTHETICAL 131.5 KDA PROTEIN CO2F12.7 IN CHROMOSOME X.
    • FEBRA20175330//D-isomer specific 2-hydroxyacid dehydrogenases
    • HEART10001420//Mus musculus skm-BOP1 (Bop) mRNA, complete cds.
    • HLUNG20024050//Rubredoxin
    • HLUNG20030420//Mus musculus mRNA for MAIL, complete cds.
    • HLUNG20030490//Ambystoma tigrinum RPE65 protein mRNA, complete cds.
    • HLUNG20033060//Homo sapiens GAP-like protein (N61) mRNA, complete cds.
    • HLUNG20041590//ubiquitous tetratricopeptide containing protein RoXaN [Homo sapiens].
    • HLUNG20045340//MOB2 PROTEIN (MPS1 BINDER 2).
    • HLUNG20051330//FHIPEP family
    • HLUNG20070410//Dihydropyridine sensitive L-type calcium channel (Beta subunit)
    • HLUNG20072100//Gallus gallus Dach2 protein (Dach2) mRNA, complete cds.
    • HLUNG20083480//Chicken mRNA for TSC-22 variant, complete cds, clone SLFEST52.
    • KIDNE20027980//SAM domain (Sterile alpha motif)
    • KIDNE20084730//Homo sapiens FH1/FH2 domain-containing protein FHOS (FHOS) mRNA, complete cds.
    • KIDNE20149780//NG28 [Mus musculus]
    • KIDNE20154330//Rattus norvegicus mRNA for multi PDZ domain protein.
    • KIDNE20170400//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Protein kinase C terminal domain//Rubredoxin
    • KIDNE20189890//Homo sapiens mRNA for KARP-1-binding protein 2 (KAB2), complete cds.
    • LIVER20010760//Homo sapiens C-type lectin-like receptor-1 mRNA, complete cds.
    • LIVER20040740//RETINAL-BINDING PROTEIN (RALBP).
    • MESAN20009090//Homo sapiens CEGP1 protein (CEGP1), mRNA
    • MESAN20026870//PAN domain//TBC domain
    • MESAN20090190//CEGP1 protein [Homo sapiens].
    • NT2NE20059680//Homo sapiens integrin cytoplasmic domain associated protein (Icap-1a) mRNA, complete cds.
    • NT2NE20077270//Adenovirus EB1 55K protein/large t-antigen
    • NT2NE20087850//ANTER-SPECIFIC PROLINE-RICH PROTEIN APG (PROTEIN CEX) (FRAGMENT).
    • NT2NE20095230//Homo sapiens HSKM-B (HSKM-B) mRNA, complete cds.
    • NT2NE20108420//KES1 PROTEIN.
    • NT2NE20173970//Rattus norvegicus beta-catenin binding protein mRNA, complete cds.
    • NT2NE20177210//Leishmania major partial ppg1 gene for proteophosphoglycan.
    • NT2RP70012830//CALPHOTIN.
    • NT2RP70035110//Caenorhabditis elegans UNC-89 (unc-89) gene, complete cds.
    • NTONG20002230//Mus musculus RW1 protein mRNA, complete cds.
    • NTONG20005310//Ribosomal protein S9/S16
    • NTONG20029850//CALCYPHOSINE (R2D5 ANTIGEN).
    • NTONG20035150//RING CANAL PROTEIN (KELCH PROTEIN).
    • NTONG20058220//Homo sapiens phosphoprotein pp75 mRNA, partial cds.
    • OCBBF20005220//Rattus norvegicus Fos-related antigen mRNA, complete cds.
    • OCBBF20011860//Mus musculus epithelial protein lost in neoplasm-a (Eplin) mRNA, complete cds.
    • OCBBF20016810//enhancer of polycomb [Mus musculus]
    • OCBBF20147070//DNA polymerase (viral) C-terminal domain
    • OCBBF20160380//liver stage antigen LSA-1—Plasmodium falciparum
    • OCBBF20177910//Corticotropin-releasing factor family
    • PEBLM20005020//Virion host shutoff protein
    • PLACE60055460//Homo sapiens leucine-zipper protein FKSG13 (FKSG13) mRNA, complete cds.
    • PLACE60068710//SUPPRESSOR PROTEIN SRP40.
    • PLACE60080360//mucin [Homo sapiens]
    • PLACE60082850//Pathogenesis-related protein Bet v I family
    • PLACE60098350//Human hepatocellular carcinoma associated protein (JCL-1) mRNA, complete cds.
    • PLACE60105680//Homo sapiens mRNA for TU12B1-TY, complete cds.
    • PLACE60119700//Homo sapiens mRNA for ABP32, complete cds.
    • PLACE60120280//SER/THR-RICH PROTEIN T10 IN DGCR REGION.
    • PLACE60132200//TRICHOHYALIN.
    • PLACE60181870//Pentaxin family
    • PROST20084470//Plasmodium berghei strain NYU2 merozoite surface protein-1 mRNA, partial cds.
    • PROST20087240//gag gene protein p24 (core nucleocapsid protein)
    • PROST20122490//Gallus gallus syndesmos mRNA, complete cds.
    • PROST20130320//S-100/ICaBP type calcium binding domain
    • PROST20152870//Homo sapiens APC2 gene, exon 14.
    • PUAEN10001640//Mus musculus cerebellar postnatal development protein-1 (Cpd1) mRNA, partial cds.
    • PUAEN20000800//Bleomycin resistance protein
    • SMINT20012220//Collagen triple helix repeat (20 copies)
    • SMINT20035510//Drosophila melanogaster La related protein (larp) mRNA, partial cds.
    • SMINT20036440//Drosophila melanogaster epsin-like protein mRNA, complete cds.
    • SMINT20038660//Homo sapiens HNOEL-iso (HNOEL-iso) mRNA, complete cds.
    • SMINT20043390//Ras association (RalGDS/AF-6) domain
    • SMINT20048720//Cytochrome P450//Cytochrome P450
    • SMINT20052130//Rattus norvegicus mRNA for gankyrin homologue, complete cds.
    • SMINT20054050//ABC1 PROTEIN HOMOLOG PRECURSOR.
    • SPLEN20024770//Rattus norvegicus (rsec6) mRNA, complete cds.
    • SPLEN20040780//CORNIFIN B (SMALL PROLINE-RICH PROTEIN 1B) (SPR1B) (SPR1 B).
    • SPLEN20041810//BC-2 protein [Homo sapiens]
    • SPLEN20100040//258.1 KDA PROTEIN C210RF5 (KIAA0933).
    • SPLEN20104150//Ribosomal protein L36
    • SPLEN20116720//Homo sapiens misato mRNA, partial cds.
    • SPLEN20176130//Homo sapiens mRNA for ALEX1, complete cds.
    • SPLEN20181570//TRICHOHYALIN.
    • TESTI20004310//TRICHOHYALIN.
    • TESTI20016970//TPR Domain
    • TESTI20030440//TRICHOHYALIN.
    • TESTI20043180//mouse mRNA for megakaryocyte potentiating factor, complete cds.
    • TESTI20043910//IQ calmodulin-binding motif//IQ calmodulin-binding motif//IQ calmodulin-binding motif//IQ calmodulin-binding motif//IQ calmodulin-binding motif
    • TESTI20044900//Strongylocentrotus purpuratus radial spokehead mRNA, complete cds.
    • TESTI20046110//Extracellular link domain
    • TESTI20047930//Homo sapiens NY-REN-2 antigen mRNA, complete cds.
    • TEST120049410//Proprotein convertase P-domain
    • TESTI20053950//IQ calmodulin-binding motif
    • TESTI20054700//Streptococcus pneumoniae strain g375 surface protein PspC (pspC) gene, pspC-8.1 allele, complete cds.
    • TESTI20055880//Serum amyloid A protein
    • TESTI20056030//Homo sapiens 88-kDa Golgi protein (GM88) mRNA, complete cds.
    • TESTI20061090//Keratin, high sulfur B2 protein
    • TESTI20064370//TPR Domain//TPR Domain//TPR Domain//TPR Domain//Synaptobrevin
    • TESTI20084250//OXYSTEROL-BINDING PROTEIN.
    • TESTI20092170//ENV polyprotein (coat polyprotein)
    • TESTI20116050//UBX domain
    • TESTI20120500//Kelch motif//Kelch motif
    • TESTI20126280//Mus musculus STAP mRNA for sperm tail associated protein, complete cds.
    • TESTI20144390//TESTIS-SPECIFIC PROTEIN PBS13.
    • TESTI20165990//Ribosomal protein L36
    • TESTI20169500//HYPOTHETICAL 51.9 KDA PROTEIN C27F1.04C IN CHROMOSOME I.
    • TESTI20170280//Flagellar L-ring protein
    • TESTI20176450//thioredoxin interacting factor [Mus musculus].
    • TESTI20179230//Dihydropyridine sensitive L-type calcium channel (Beta subunit)
    • TESTI20180600//Homo sapiens HOM-TES-85 tumor antigen mRNA, complete cds.
    • TESTI20209050//HYPOTHETICAL 113.1 KDA PROTEIN IN PRE5-FET4 INTERGENIC REGION.
    • TESTI20210570//RETINAL-BINDING PROTEIN (RALBP).
    • TESTI20215310//Homo sapiens calcyclin binding protein mRNA, complete cds.
    • TESTI20247440//Human BLu protein testis isoform (BLu) mRNA, complete cds.
    • TESTI20249360//Homo sapiens DEME-6 mRNA, partial cds.
    • TESTI20250220//TRICHOHYALIN.
    • TESTI20251440//Rattus norvegicus (rsec6) mRNA, complete cds.
    • TESTI20255460//Mus musculus mRNA for MIWI (piwi), complete cds.
    • THYMU20009500//TPR Domain
    • THYMU20010180//MOB1 PROTEIN (MPS1 BINDER 1).
    • THYMU20013810//Human SEC7 homolog Tic (TIC) mRNA, complete cds.
    • THYMU20018250//TPR Domain
    • THYMU20026950//Mus musculus ROSA 26 transcription AS ROSA26AS mRNA, complete cds.
    • THYMU20028410//Mus musculus Pax transcription activation domain interacting protein PTIP mRNA, complete cds.
    • THYMU20030460//Homo sapiens tumor endothelial marker 7 precursor (TEM7) mRNA, complete cds.
    • THYMU20031330//Homo sapiens putative nucleotide binding protein mRNA, complete cds.
    • THYMU20052460//PHORBOLIN I (FRAGMENTS).
    • THYMU20055450//Zona pellucida-like domain
    • THYMU20083830//Homo sapiens angiostatin binding protein 1 mRNA, complete cds.
    • THYMU20139160//Uncharacterized protein family UPF0031
    • THYMU20151610//Homo sapiens antigen NY-CO-1 (NY-CO-1) mRNA, complete cds.
    • TRACH20093400//TRICHOHYALIN.
    • TRACH20104510//Uncharacterized protein family UPF0005
    • TRACH20122980//HYPOTHETICAL PROTEIN MJ0798.
    • TRACH20139280//PX domain
    • TRACH20164810//D-isomer specific 2-hydroxyacid dehydrogenases
    • TRACH20165540//Human alpha-1 type I collagen gene surrounding osteogenesis imperfecta OI type II deletion.
    • UTERU20051790//guanylate kinase-interacting protein 1 Maguin-1, membrane-associated—rat
    • UTERU20083020//Domain of unknown function DUF71
    • UTERU20121140//Rhodanese-like domain
    • UTERU20128560//26.4 KDA PROTEIN IN RUVC-ASPS INTERGENIC REGION.
    • UTERU20132620//AXONEME-ASSOCIATED PROTEIN MST101 (2).
    • UTERU20134830//pellino (Drosophila) homolog 2 [Homo sapiens]
    • UTERU20181270//Zinc knuckle
  • With respect to the remaining 613 clones, there are so far no information available for estimating their functions. However, there is the possibility that the functions of these clones will be revealed in future. Their Clone Names are indicated below.
    ADRGL20027530, ADRGL20040310, ADRGL20040770, ADRGL20046760,
    ADRGL20047080, ADRGL20057560, ADRGL20067320, ADRGL20095330,
    ASTRO20003720, ASTRO20004820, ASTRO20012270, ASTRO20020350,
    ASTRO20022020, ASTRO20027330, ASTRO20047510, ASTRO20069200,
    ASTRO20076660, ASTRO20091770, ASTRO20141740, BNGH410000570,
    BNGH420014060, BNGH420040760, BNGH420042910, BNGH420045380,
    BNGH420061350, BNGH420062340, BNGH420085100, BRACE20009050,
    BRACE20017790, BRACE20018810, BRACE20025820, BRACE20038920,
    BRACE20054480, BRACE20057870, BRACE20059110, BRACE20062580,
    BRACE20069440, BRACE20098860, BRACE20196960, BRACE20200970,
    BRACE20205840, BRACE20207420, BRACE20212450, BRACE20216700,
    BRACE20219360, BRAMY10000980, BRAMY20000210, BRAMY20000250,
    BRAMY20020440, BRAMY20021580, BRAMY20023390, BRAMY20036530,
    BRAMY20036810, BRAMY20039290, BRAMY20043520, BRAMY20050640,
    BRAMY20052440, BRAMY20073080, BRAMY20074110, BRAMY20074860,
    BRAMY20076130, BRAMY20076530, BRAMY20095080, BRAMY20095570,
    BRAMY20100680, BRAMY20107980, BRAMY20120170, BRAMY20124970,
    BRAMY20125170, BRAMY20126910, BRAMY20139750, BRAMY20155500,
    BRAMY20159250, BRAMY20160020, BRAMY20173480, BRAMY20219620,
    BRAMY20225250, BRAMY20227230, BRAMY20227960, BRAMY20243120,
    BRAMY20245350, BRAMY20267780, BRAMY20269040, BRAMY20271140,
    BRAMY20287400, BRAWH20020600, BRAWH20025490, BRAWH20027250,
    BRAWH20055240, BRAWH20055780, BRAWH20058120, BRAWH20078080,
    BRAWH20082550, BRAWH20173790, BRAWH20175230, BRAWH20175340,
    BRAWH20182670, BRAWH20186010, BRCOC10000400, BRHIP20003590,
    BRHIP20005060, BRSSN20092440, CTONG10000090, CTONG20000340,
    CTONG20002790, CTONG20008460, CTONG20015240, CTONG20020660,
    CTONG20027660, CTONG20031150, CTONG20031890, CTONG20033500,
    CTONG20035240, CTONG20036800, CTONG20039370, CTONG20050490,
    CTONG20055670, CTONG20057750, CTONG20057950, CTONG20061290,
    CTONG20062730, CTONG20065240, CTONG20073990, CTONG20074740,
    CTONG20076230, CTONG20081840, CTONG20133720, CTONG20165590,
    CTONG20166580, CTONG20168460, CTONG20169530, CTONG20174440,
    CTONG20179390, CTONG20179980, CTONG20180620, CTONG20181350,
    CTONG20184130, CTONG20186140, CTONG20190630, DFNES20032550,
    DFNES20088810, FCBBF10002200, FCBBF20021110, FCBBF20028980,
    FCBBF20038230, FCBBF20038950, FCBBF20061310, FCBBF20070800,
    FCBBF30000010, FCBBF30001020, FCBBF30001150, FCBBF30002330,
    FCBBF30004730, FCBBF30005180, FCBBF30019240, FCBBF30056980,
    FCBBF30063990, FCBBF30068210, FCBBF30072480, FCBBF30074530,
    FCBBF30074620, FCBBF30081000, FCBBF30088700, FCBBF30089380,
    FCBBF30091010, FCBBF30099490, FCBBF30101240, FCBBF30101300,
    FCBBF30105080, FCBBF30106950, FCBBF30107330, FCBBF30114180,
    FCBBF30115230, FCBBF30128420, FCBBF30130580, FCBBF30151190,
    FCBBF30170710, FCBBF30179180, FCBBF30181730, FCBBF30194370,
    FCBBF30195700, FCBBF40001920, FCBBF40005000, FCBBF50000410,
    FEBRA20035200, FEBRA20039070, FEBRA20040260, FEBRA20040290,
    FEBRA20076200, FEBRA20078180, FEBRA20082660, FEBRA20083410,
    FEBRA20086600, FEBRA20091620, FEBRA20093270, FEBRA20093280,
    FEBRA20095410, FEBRA20098040, FEBRA20101410, FEBRA20108020,
    FEBRA20108580, FEBRA20121200, FEBRA20163980, FEBRA20175020,
    FEBRA20180510, FEBRA20187460, HHDPC20082970, HLUNG20009260,
    HLUNG20009550, HLUNG20010130, HLUNG20011440, HLUNG20012140,
    HLUNG20020500, HLUNG20021450, HLUNG20023030, HLUNG20025620,
    HLUNG20029420, HLUNG20030610, HLUNG20031620, HLUNG20033310,
    HLUNG20037140, HLUNG20037780, HLUNG20038330, HLUNG20047070,
    HLUNG20055240, HLUNG20056560, HLUNG20057380, HLUNG20059240,
    HLUNG20065700, HLUNG20067810, HLUNG20072190, HLUNG20072450,
    HLUNG20079310, HLUNG20083840, HLUNG20083960, HLUNG20093030,
    HLUNG20094130, KIDNE20011600, KIDNE20024380, KIDNE20086970,
    KIDNE20091090, KIDNE20094260, KIDNE20095530, KIDNE20137310,
    KIDNE20138450, KIDNE20141120, KIDNE20142680, KIDNE20154830,
    KIDNE20155980, KIDNE20157100, KIDNE20176030, KIDNE20181670,
    KIDNE20191870, LIVER20007690, LIVER20032340, MESAN20008940,
    MESAN20021860, MESAN20029780, MESAN20030390, MESAN20041380,
    MESAN20045750, MESAN20060220, MESAN20085360, MESAN20089260,
    MESAN20094180, NESOP20005040, NT2NE20028700, NT2NE20033150,
    NT2NE20045190, NT2NE20047870, NT2NE20062880, NT2NE20066590,
    NT2NE20070520, NT2NE20073650, NT2NE20077860, NT2NE20086070,
    NT2NE20088030, NT2NE20104000, NT2NE20107810, NT2NE20112210,
    NT2NE20114850, NT2NE20123610, NT2NE20124570, NT2NE20126030,
    NT2NE20140280, NT2NE20148690, NT2NE20149500, NT2NE20150610,
    NT2NE20157120, NT2NE20165190, NT2NE20181760, NT2NE20184720,
    NT2RP70022820, NT2RP70049610, NT2RP70056290, NT2RP70074800,
    NT2RP70080150, NT2RP70084540, NTONG20017620, NTONG20049180,
    OCBBF20001780, OCBBF20009820, OCBBF20109450, OCBBF20112320,
    OCBBF20115360, OCBBF20117220, OCBBF20119810, OCBBF20142290,
    OCBBF20152330, OCBBF20188280, PLACE60001910, PLACE60011180,
    PLACE60017120, PLACE60055350, PLACE60062870, PLACE60063940,
    PLACE60069880, PLACE60072390, PLACE60072420, PLACE60077870,
    PLACE60081260, PLACE60088240, PLACE60092280, PLACE60092370,
    PLACE60095240, PLACE60109910, PLACE60132320, PLACE60132880,
    PLACE60155910, PLACE60157310, PLACE60162100, PLACE60175640,
    PLACE60177910, PROST10001360, PROST10002150, PROST20011800,
    PROST20014140, PROST20014650, PROST20015400, PROST20022120,
    PROST20036280, PROST20041460, PROST20042700, PROST20047440,
    PROST20048170, PROST20052720, PROST20054660, PROST20060200,
    PROST20078710, PROST20093470, PROST20094000, PROST20097310,
    PROST20097360, PROST20102500, PROST20103820, PROST20121570,
    PROST20124000, PROST20125420, PROST20138730, PROST20156360,
    PROST20159320, SKMUS20026340, SKMUS20064810, SKNSH10001010,
    SKNSH20007160, SKNSH20040390, SKNSH20068220, SMINT20011830,
    SMINT20013970, SMINT20014610, SMINT20017310, SMINT20021260,
    SNINT20023110, SMINT20031280, SMINT20045830, SMINT20045890,
    SMINT20047290, SMINT20056240, SMINT20067080, SMINT20070620,
    SMINT20077920, SMINT20084910, SMINT20085310, SMINT20085450,
    SMINT20089210, SMINT20092120, SMINT20093630, SMINT20094150,
    SPLEN20005160, SPLEN20005370, SPLEN20012450, SPLEN20015030,
    SPLEN20016500, SPLEN20019120, SPLEN20020530, SPLEN20023430,
    SPLEN20024510, SPLEN20029170, SPLEN20036780, SPLEN20043430,
    SPLEN20043460, SPLEN20045550, SPLEN20051420, SPLEN20062830,
    SPLEN20067010, SPLEN20076190, SPLEN20081640, SPLEN20087370,
    SPLEN20087860, SPLEN20108460, SPLEN20110210, SPLEN20111450,
    SPLEN20114190, SPLEN20117580, SPLEN20126110, SPLEN20137530,
    SPLEN20192570, SPLEN20193750, SPLEN20197090, SPLEN20197740,
    SPLEN20199850, SPLEN20200076, SPLEN20200340, SPLEN20203590,
    SPLEN20205120, TESOP10001600, TESTI10000850, TESTI20005980,
    TESTI20012360, TESTI20019590, TESTI20028020, TESTI20030610,
    TESTI20034750, TESTI20035330, TESTI20040850, TESTI20045740,
    TESTI20049990, TESTI20050170, TESTI20052670, TESTI20053800,
    TESTI20059330, TESTI20059370, TESTI20059790, TESTI20060150,
    TESTI20060450, TESTI20062180, TESTI20062580, TESTI20064990,
    TESTI20066170, TESTI20066280, TESTI20066590, TESTI20067350,
    TESTI20068940, TESTI20076920, TESTI20079060, TESTI20080460,
    TESTI20083890, TESTI20085670, TESTI20089290, TESTI20090180,
    TESTI20090970, TESTI20091360, TESTI20093900, TESTI20094620,
    TESTI20097270, TESTI20107340, TESTI20113150, TESTI20117500,
    TESTI201184S0, TESTI20122440, TESTI20124440, TESTI20125440,
    TESTI20132680, TESTI20134010, TESTI20134270, TESTI20142480,
    TESTI20151050, TESTI20152490, TESTI20159380, TESTI20161010,
    TESTI20165680, TESTI20167580, TESTI20170690, TESTI20170890,
    TESTI20173110, TESTI20179510, TESTI20182210, TESTI20184280,
    TESTI20184820, TESTI20192570, TESTI20193520, TESTI20197290,
    TESTI20198600, TESTI20199980, TESTI20200120, TESTI20200840,
    TESTI20205150, TESTI20211380, TESTI20219390, TESTI20221790,
    TESTI20223380, TESTI20248850, TESTI20254090, TESTI20254480,
    TESTI20259200, TESTI20260140, TESTI20265150, TESTI20265340,
    TESTI20265890, TESTI20269250, TESTI20269360, TESTI20272380,
    TESTI20277300, TESTI20287760, THYMU20007750, THYMU20008000,
    THYMU20009460, THYMU20009710, THYMU20010710, THYMU20012560,
    THYMU20014430, THYMU20018390, THYMU20019000, THYMU20020370,
    THYMU20021540, THYMU20029830, THYMU20036500, THYMU20043440,
    THYMU20043560, THYMU20044100, THYMU20044520, THYMU20051340,
    THYMU20058550, THYMU20060480, THYMU20062520, THYMU20064680,
    THYMU20069130, THYMU20069460, THYMU20069650, THYMU20071460,
    THYMU20072580, THYMU20073070, THYMU20073080, THYMU20078020,
    THYMU20080490, THYMU20083500, THYMU20084520, THYMU20086430,
    THYMU20089170, THYMU20089900, THYMU20091040, THYMU20112570,
    THYMU20115730, THYMU20117850, THYMU20128910, THYMU20129020,
    THYMU20130470, THYMU20134260, THYMU20140510, THYMU20148010,
    THYMU20149230, THYMU20157620, THYMU20174490, THYMU20174790,
    THYMU20175260, THYMU20177070, THYMU20181890, THYMU20187210,
    TKIDN10001710, TRACH20012490, TRACH20021000, TRACH20025370,
    TRACH20026640, TRACH20041090, TRACH20044990, TRACH20049500,
    TRACH20051590, TRACH20057200, TRACH20080810, TRACH20093480,
    TRACH20101590, TRACH20123870, TRACH20124970, TRACH20125620,
    TRACH20129180, TRACH20140180, TRACH20158240, TRACH20160800,
    TRACH20174980, TRACH20182780, TRACH20185120, UTERU10001870,
    UTERU20000230, UTERU20011760, UTERU20013890, UTERU20027360,
    UTERU20029930, UTERU20031350, UTERU20040370, UTERU20040390,
    UTERU20040730, UTERU20041970, UTERU20065470, UTERU20079240,
    UTERU20090940, UTERU20091470, UTERU20102260, UTERU20103040,
    UTERU20106510, UTERU20140010, UTERU20167570, UTERU20173030,
    UTERU20176230
    • EXAMPLE 7 Expression Frequency Analysis In Silico
  • The cDNA libraries derived from various tissues and cells as indicated in Example 1 were prepared, and cDNA clones were selected from each library at random. The 5′-end sequences were determined and the database was constructed based on the data. The database was constructed based on the nucleotide sequences of 770,546 clones, and thus the population of the database is large enough for the analysis.
  • Then, clones having a homologous sequence are categorized into a single cluster (clustering) by searching the nucleotide sequences of respective clones in this database with the program of nucleotide sequence homology search; the number of clones belonging to each cluster was determined and normalized for every library; thus, the ratio of a certain gene in each cDNA library was determined. This analysis gave the information of the expression frequency of genes in tissues and cells which were sources of the cDNA libraries.
  • Then, in order to analyze the expression of a gene containing the nucleotide sequence of the cDNA of the present invention in tissues and cells, the library derived from a tissue or a cell used in the large-scale cDNA analysis was subjected to the comparison of the expression levels between tissues or cells. Namely, the expression frequency was analyzed by comparing the previously normalized values between tissues and/or cells for which the nucleotide sequences of 600 or more cDNA clones had been analyzed. By this analysis, some of the genes were revealed to be involved in the pathology and functions indicated below. Each value in Tables 3 to 39 shown below represents a relative expression frequency; the higher the value, the higher the expression level.
  • Osteoporosis-Related Genes
  • Osteoporosis is a pathology in which bones are easily broken owing to overall decrease in components of bone. The onset involves the balance between the functions of osteoblast producing bone and osteoclast absorbing bone, namely bone metabolism. Thus, the genes involved in the increase of osteoclasts differentiating from precursor cells of monocyte/macrophage line (Molecular Medicine 38. 642-648. (2001)) are genes involved in osteoporosis relevant to bone metabolism.
  • A nucleotide sequence information-based analysis was carried out to identify the genes whose expression frequencies are higher or lower in CD34+ cell (cell expressing a glycoprotein CD34) treated with the osteoclast differentiation factor (Molecular Medicine 38. 642-648. (2001)) than in the untreated CD34+ cell, which is the precursor cell of monocyte/macrophage line. The result of comparative analysis for the frequency between the two cDNA libraries prepared from the RNA of CD34+ cells (CD34C) and from the RNA of CD34+ cells treated with the osteoclast differentiation factor (D30ST, D60ST or D90ST) showed that the genes whose expression levels were different between the two were the following clones (Table 3).
    ASTRO20010290, BRAMY20036530, BRAMY20043630,
    BRAMY20089770, BRAMY20190550, CD34C20001750,
    FCBBF20066340, FEBRA20040290, HLUNG20015180,
    HLUNG20041590, HLUNG20052300, KIDNE20084040,
    MESAN20021860, MESAN20027240, NTONG20055200,
    PROST20016760, PUAEN10001640, SMINT20006020,
    SMINT20028840, SMINT20035050, SPLEN20181570,
    TESTI20064530, TESTI20210030, THYMU20029830,
    THYMU20139160, TRACH20051590
  • These genes are involved in osteoporosis.
  • Genes Involved in Neural Cell Differentiation
  • Genes involved in neural cell differentiation are useful for treating neurological diseases. Genes with varying expression levels in response to induction of cellular differentiation in neural cells are thought to be involved in neurological diseases.
  • A survey was performed for genes whose expression levels are varied in response to induction of differentiation (stimulation by retinoic acid (RA) or growth inhibitor treatment after RA stimulation) in cultured cells of a neural strain, NT2. The result of comparative analysis of cDNA libraries derived from undifferentiated NT2 cells (NT2RM) and the cells subjected to the differentiation treatment (NT2RP, NT2RI or NT2NE) showed that the genes whose expression levels were different between the two were the following clones (Table 4).
    ADRGL20023920, ASTRO20009140, BNGH420077980, BNGH420086030,
    BRACE20062580, BRACE20079370, BRACE20215410, BRAMY20003540,
    BRAMY20043630, BRAMY20076130, BRAMY20095080, BRAMY20227860,
    BRAWH20082550, BRHIP10001040, BRSSN20005610, CTONG20027660,
    CTONG20044230, CTONG20066110, CTONG20079590, CTONG20084660,
    CTONG20133720, CTONG20165750, CTONG20188080, FCBBF20023490,
    FCBBF20033360, FCBBF20059660, FCBBF20070950, FCBBF30004340,
    FCBBF30095410, FCBBF30125460, FCBBF30179180, FCBBF30236670,
    FCBBF30257370, FCBBF50000610, FCBBF50001650, FEBRA20038330,
    FEBRA20039260, FEBRA20063720, FEBRA20090220, FEBRA20150420,
    HEART10001490, HLUNG20032460, HLUNG20041590, KIDNE20089870,
    MESAN20016270, MESAN20021860, MESAN20060430, MESAN20067430,
    NT2NE20018740, NT2NE20018890, NT2NE20021860, NT2NE20026200,
    NT2NE20026510, NT2NE20028700, NT2NE20033150, NT2NE20037050,
    NT2NE20038870, NT2NE20039210, NT2NE20042550, NT2NE20045190,
    NT2NE20047870, NT2NE20053230, NT2NE20053950, NT2NE20059210,
    NT2NE20059680, NT2NE20060750, NT2NE20061030, NT2NE20062880,
    NT2NE20064780, NT2NE20066590, NT2NE20069580, NT2NE20070520,
    NT2NE20073650, NT2NE20077250, NT2NE20077270, NT2NE20077860,
    NT2NE20079670, NT2NE20080770, NT2NE20082130, NT2NE20082600,
    NT2NE20086070, NT2NE20087270, NT2NE20087850, NT2NE20088030,
    NT2NE20092950, NT2NE20095230, NT2NE20104000, NT2NE20107810,
    NT2NE20108420, NT2NE20111190, NT2NE20112210, NT2NE20114850,
    NT2NE20117580, NT2NE20119980, NT2NE20123610, NT2NE20124570,
    NT2NE20126030, NT2NE20127900, NT2NE20140130, NT2NE20140280,
    NT2NE20141040, NT2NE20145250, NT2NE20146510, NT2NE20148690,
    NT2NE20149500, NT2NE20150610, NT2NE20152620, NT2NE20153620,
    NT2NE20155650, NT2NE20157120, NT2NE20165190, NT2NE20167660,
    NT2NE20173970, NT2NE20177210, NT2NE20181760, NT2NE20181800,
    NT2NE20184720, NT2RI20016240, NT2RI20021200, NT2RI20033920,
    NT2RI20093010, NT2RP70001120, NT2RP70001730, NT2RP70003110,
    NT2RP70012830, NT2RP70022820, NT2RP70027790, NT2RP70029780,
    NT2RP70030840, NT2RP70031070, NT2RP70031340, NT2RP70031480,
    NT2RP70035110, NT2RP70046410, NT2RP70049610, NT2RP70056290,
    NT2RP70056690, NT2RP70057500, NT2RP70064570, NT2RP70074800,
    NT2RP70075300, NT2RP70075800, NT2RP70080150, NT2RP70084540,
    NT2RP70087140, NT2RP70090870, OCBBF20001780, OCBBF20009820,
    OCBBF20142290, OCBBF20155030, OCBBF20175360, OCBBF20177540,
    OCBBF20177910, PLACE60054820, PLACE60061370, PLACE60073090,
    PLACE60162100, PROST20011800, PROST20045700, PROST20078710,
    PROST20094000, PUAEN10000650, PUAEN10001640, SKNMC20006350,
    SMINT20016150, SMINT20030740, SMINT20035510, SMINT20039050,
    SMINT20047290, SPLEN20063250, SPLEN20117580, SPLEN20125230,
    TESTI20030610, TESTI20043910, TESTI20066280, TESTI20067480,
    TESTI20105130, TESTI20106170, TESTI20143180, TESTI20221790,
    TESTI20254090, TESTI20274960, THYMU10004280, THYMU20007020,
    THYMU20104480, THYMU20139160, TRACH20026640, UTERU10001060,
    UTERU20026620, UTERU20079240, UTERU20083020, UTERU20102260,
    UTERU20132620
  • These genes are neurological disease-related genes.
  • Cancer-Related Genes
  • It has been assumed that, distinct from normal tissues, cancer tissues express a distinct set of genes, and thus the expression can contribute to the carcinogenesis in tissues and cells. Thus, the genes whose expression patterns in cancer tissues are different from those in normal tissues are cancer-related genes. Search was carried out for the genes whose expression levels in cancer tissues were different from those in normal tissues.
  • The result of comparative analysis of cDNA libraries derived from breast tumor (TBAES) and normal breast (BEAST) showed that the genes whose expression levels were different between the two were the following clones (Table 5).
  • CTONG20070780, CTONG20084660, HLUNG20045340, TESTI20047370
  • The result of comparative analysis of cDNA libraries derived cervical tumor (TCERX) and normal cervical duct (CERVX) showed that the genes whose expression levels were different between the two were the following clones (Table 6).
  • SMINT20030740
  • The result of comparative analysis of cDNA libraries derived from colon tumor (TCOLN) and normal colon (COLON) showed that the genes whose expression levels were different between the two were the following clones (Table 7).
  • UTERU2004037
  • The result of comparative analysis of cDNA libraries derived from esophageal tumor (TESOP) and normal esophagus (NESOP) showed that the genes whose expression levels were different between the two were the following clones (Table 8).
    HLUNG20015180, NESOP20004520, NESOP20005040,
    TESOP10000350, TESOP10001600, THYMU20071120
  • The result of comparative analysis of cDNA libraries derived from kidney tumor (TKIDN) and normal kidney (KIDNE) showed that the genes whose expression levels were different between the two were the following clones (Table 9).
    ASTRO20009140, ASTRO20027330, ASTRO20055930, BGGI120010750,
    BNGH420074600, BRACE20050870, BRACE20054480, BRACE20062580,
    BRACE20219360, BRAMY20003540, BRAMY20003880, BRAMY20043630,
    BRAMY20055760, BRAMY20125360, BRAMY20190550, BRAMY20204270,
    BRAMY20227860, BRAWH20014590, BRAWH20093070, BRHIP10001040,
    CTONG20033750, CTONG20039370, CTONG20045500, CTONG20079590,
    FCBBF20023490, FCBBF30004340, FCBBF30106950, FCBBF30115230,
    FCBBF30169280, FCBBF30225930, FCBBF30282020, FEBRA20038330,
    FEBRA20039260, FEBRA20040290, FEBRA20082660, FEBRA20121200,
    FEBRA20170240, HEART10001490, HLUNG20041590, HLUNG20068120,
    HLUNG20072450, HLUNG20083480, HLUNG20083960, KIDNE20011600,
    KIDNE20016360, KIDNE20024380, KIDNE20027980, KIDNE20080690,
    KIDNE20081170, KIDNE20083150, KIDNE20083620, KIDNE20084030,
    KIDNE20084040, KIDNE20084730, KIDNE20084800, KIDNE20086490,
    KIDNE20086660, KIDNE20086970, KIDNE20087880, KIDNE20088240,
    KIDNE20089870, KIDNE20091090, KIDNE20094260, KIDNE20094670,
    KIDNE20095530, KIDNE20133460, KIDNE20133880, KIDNE20134130,
    KIDNE20134890, KIDNE20137310, KIDNE20138450, KIDNE20140870,
    KIDNE20141120, KIDNE20141700, KIDNE20142680, KIDNE20142680,
    KIDNE20142900, KIDNE20143200, KIDNE20147170, KIDNE20148080,
    KIDNE20149780, KIDNE20150730, KIDNE20152440, KIDNE20154330,
    KIDNE20154830, KIDNE20155980, KIDNE20157100, KIDNE20160360,
    KIDNE20160960, KIDNE20163710, KIDNE20165390, KIDNE20169180,
    KIDNE20170400, KIDNE20173150, KIDNE20173430, KIDNE20176030,
    KIDNE20181670, KIDNE20182540, KIDNE20186170, KIDNE20188630,
    KIDNE20189890, KIDNE20189960, KIDNE20191870, MESAN20038520,
    MESAN20041380, OCBBF20016390, OCBBF20142290, OCBBF20174890,
    PLACE60061370, PLACE60073090, PLACE60181870, PROST20016760,
    PUAEN10000650, SMINT20039050, SMINT20089210, SPLEN20017610,
    SPLEN20024930, SPLEN20057830, SPLEN20063250, SPLEN20126110,
    SPLEN20135030, SPLEN20136700, TESTI20070740, TESTI20262150,
    THYMU20009500, THYMU20019260, THYMU20157620, TKIDN10000620,
    TKIDN10001710, TKIDN10001920, TRACH20011010, UMVEN10001380
  • The result of comparative analysis of cDNA libraries derived from liver tumor (TLIVE) and normal liver (LIVER) showed that the genes whose expression levels were different between the two were the following clones (Table 10).
    CTONG20069320, FCBBF30236670, FEBRA20038220,
    FEBRA20039260, KIDNE20087880, LIVER20006260,
    LIVER20007690, LIVER20007750, LIVER20010510,
    LIVER20010760, LIVER20010990, LIVER20011640,
    LIVER20013890, LIVER20026440, LIVER20030650,
    LIVER20032340, LIVER20038000, LIVER20040740,
    LIVER20055270, MESAN20027240, NT2RI20021200,
    SKMUS20006790, TESTI20035330, THYMU10004280,
    THYMU20029830
  • The result of comparative analysis of cDNA libraries derived from lung tumor (TLUNG) and normal lung (HLUNG) showed that the genes whose expression levels were different between the two were the following clones (Table 11).
    HLUNG20052300, SMINT20035050, HLUNG20041590, PROST20016760,
    BRAMY20043630, HLUNG20015180, THYMU20139160, HLUNG20020850,
    HLUNG20032460, BRAMY20204270, BRAMY20001510, BRAMY20227860,
    CTONG20029030, CTONG20168460, CTONG20186290, FEBRA20039260,
    FEBRA20078800, FEBRA20163980, HCHON20000870, HLUNG20008460,
    HLUNG20009260, HLUNG20009550, HLUNG20010130, HLUNG20011260,
    HLUNG20011440, HLUNG20011460, HLUNG20012140, HLUNG20014590,
    HLUNG20015070, HLUNG20020500, HLUNG20021450, HLUNG20023030,
    HLUNG20024050, HLUNG20025620, HLUNG20028110, HLUNG20029420,
    HLUNG20029490, HLUNG20030420, HLUNG20030490, HLUNG20030610,
    HLUNG20031620, HLUNG20033060, HLUNG20033310, HLUNG20033350,
    HLUNG20034970, HLUNG20037140, HLUNG20037160, HLUNG20037780,
    HLUNG20038330, HLUNG20041540, HLUNG20042730, HLUNG20045340,
    HLUNG20047070, HLUNG20050760, HLUNG20051330, HLUNG20054790,
    HLUNG20055240, HLUNG20056560, HLUNG20057380, HLUNG20059240,
    HLUNG20060670, HLUNG20063700, HLUNG20065700, HLUNG20065990,
    HLUNG20067810, HLUNG20068120, HLUNG20069350, HLUNG20070410,
    HLUNG20072100, HLUNG20072190, HLUNG20072450, HLUNG20074330,
    HLUNG20079310, HLUNG20081390, HLUNG20081530, HLUNG20082350,
    HLUNG20083330, HLUNG20083480, HLUNG20083840, HLUNG20083960,
    HLUNG20084790, HLUNG20085210, HLUNG20088750, HLUNG20092530, HLUNG20093030,
    HLUNG20094130, KIDNE20142900, PROST20052850, SKNMC20006350, SPLEN20012450,
    TESTI20057590, TESTI20061200, TESTI20067480, TESTI20116050,
    THYMU10004280, THYMU20010180, TRACH20011010, UTERU20016580, UTERU20127030
  • The result of comparative analysis of cDNA libraries derived from ovary tumor (TOVER) and normal ovary (NOVER) showed the genes whose expression levels were different between the two were the following clones (Table 12).
  • KIDNE20089870, NT2RP70075300, TESTI20132310
  • The result of comparative analysis of cDNA libraries derived from stomach tumor (TSTOM) and normal stomach (STOMA) showed that the genes whose expression levels were different between the two were the following clones (Table 13).
    BNGH420087430, BRAMY20227860, BRAWH20027250,
    CTONG20174440, FEBRA20090220, PUAEN10000650,
    SMINT20023110, SMINT20030740, SMINT20045890,
    SPLEN20048800, SPLEN20139360, TESTI20063410,
    TESTI20150920, TRACH20026640, UTERU20041970
  • The result of comparative analysis of cDNA libraries derived from uterine tumor (TUTER) and normal uterus (UTERU) showed that the genes whose expression levels were different between the two were the following clones (Table 14).
    ADRGL20020290, BRACE20038920, BRAMY20091230, BRAMY20093490,
    BRAMY20227860, BRHIP20005060, CTONG20069320, CTONG20083430,
    FCBBF30005360, FCBBF30257370, FEBRA20038330, FEBRA20039260,
    FEBRA20040260, FEBRA20078180, FEBRA20087550, HLUNG20015070,
    HLUNG20015180, MESAN20007110, MESAN20067430, MESAN20095800,
    NT2RP70057500, SKMUS20008730, SKNMC20006350, SMINT20035050,
    SMINT20045890, SPLEN20073880, SPLEN20076470, SPLEN20118050,
    TESTI20030610, TESTI20035330, TESTI20057590, TESTI20059080,
    TESTI20105130, THYMU10004280, THYMU20139160, UTERU10001060,
    UTERU10001870, UTERU20000230, UTERU20000950, UTERU20011760,
    UTERU20013890, UTERU20016580, UTERU20026620, UTERU20027360,
    UTERU20029930, UTERU20031350, UTERU20035770, UTERU20040150,
    UTERU20040370, UTERU20040390, UTERU20040730, UTERU20041630,
    UTERU20041970, UTERU20045200, UTERU20051790, UTERU20064120,
    UTERU20065470, UTERU20079240, UTERU20083020, UTERU20086530,
    UTERU20087070, UTERU20087850, UTERU20089300, UTERU20089390,
    UTERU20089620, UTERU20090940, UTERU20091470, UTERU20094830,
    UTERU20095100, UTERU20099040, UTERU20099510, UTERU20101150,
    UTERU20102260, UTERU20103040, UTERU20103200, UTERU20104310,
    UTERU20106510, UTERU20121140, UTERU20122520, UTERU20125810,
    UTERU20127030, UTERU20127150, UTERU20128560, UTERU20132620, UTERU20134830,
    UTERU20139760, UTERU20140010, UTERU20167570, UTERU20168960, UTERU20169020,
    UTERU20173030, UTERU20176230, UTERU20177150, UTERU20181270, UTERU20185220,
    UTERU20188670, UTERU20188840
  • The result of comparative analysis of cDNA libraries derived from tongue cancer (CTONG) and normal tongue (NTONG) showed that the genes whose expression levels were different between the two were the following clones (Table 15).
    ADRGL20023920, BRACE20038920, BRACE20050870, BRACE20061620,
    BRAMY20036530, BRAMY20076130, BRAMY20204270, BRAMY20267780,
    BRCAN10001680, CTONG10000090, CTONG20000340, CTONG20002790,
    CTONG20004110, CTONG20004520, CTONG20007660, CTONG20008190,
    CTONG20008460, CTONG20015240, CTONG20017490, CTONG20020660,
    CTONG20020950, CTONG20027660, CTONG20029030, CTONG20030280,
    CTONG20031150, CTONG20031890, CTONG20032930, CTONG20033500,
    CTONG20033610, CTONG20033750, CTONG20035240, CTONG20036800,
    CTONG20036990, CTONG20039370, CTONG20041150, CTONG20041260,
    CTONG20042640, CTONG20044230, CTONG20044870, CTONG20045500,
    CTONG20046690, CTONG20049480, CTONG20050490, CTONG20051100,
    CTONG20051450, CTONG20052780, CTONG20053990, CTONG20055670,
    CTONG20055850, CTONG20056150, CTONG20057750, CTONG20057950,
    CTONG20059130, CTONG20060040, CTONG20061290, CTONG20062730,
    CTONG20063770, CTONG20063930, CTONG20065240, CTONG20065680,
    CTONG20066110, CTONG20068360, CTONG20069320, CTONG20069420,
    CTONG20070090, CTONG20070720, CTONG20070780, CTONG20070910,
    CTONG20071040, CTONG20071680, CTONG20072930, CTONG20073990,
    CTONG20074000, CTONG20074170, CTONG20074740, CTONG20076230,
    CTONG20076810, CTONG20077760, CTONG20078340, CTONG20079590,
    CTONG20080140, CTONG20081840, CTONG20083430, CTONG20083980,
    CTONG20084020, CTONG20084660, CTONG20085210, CTONG20133720,
    CTONG20165590, CTONG20165750, CTONG20166580, CTONG20167750,
    CTONG20168240, CTONG20168460, CTONG20169040, CTONG20169530,
    CTONG20170940, CTONG20174290, CTONG20174580, CTONG20176040,
    CTONG20179390, CTONG20179890, CTONG20179980, CTONG20180620,
    CTONG20180690, CTONG20181350, CTONG20183430, CTONG20183830,
    CTONG20184130, CTONG20184830, CTONG20186140, CTONG20186290,
    CTONG20186370, CTONG20186520, CTONG20186550, CTONG20188080,
    CTONG20189000, CTONG20190290, CTONG20190630, FCBBF20070950,
    FCBBF30001100, FCBBF30175350, FCBBF40005000, FEBRA20027070,
    FEBRA20038330, FEBRA20039260, FEBRA20040290, FEBRA20046200,
    FEBRA20063720, FEBRA20078800, FEBRA20090220, HCHON20000870,
    HLUNG20068120, MESAN20008150, MESAN20027900, NT2NE20153620,
    NT2RP70001730, NT2RP70012830, NT2R270027790, NT2RP70057500,
    NT2RP70064570, NT2RP70090870, NTONG20002230, NTONG20005310,
    NTONG20017620, NTONG20029850, NTONG20031580, NTONG20032100,
    NTONG20034540, NTONG20035150, NTONG20043080, NTONG20048440,
    NTONG20049180, NTONG20053630, NTONG20053730, NTONG20053910,
    NTONG20055200, NTONG20058010, NTONG20058220, OCBBF20110730,
    OCBBF20177540, OCBBF20177910, PROST20016760, PROST20042700,
    PROST20050390, PROST20063430, PROST20130320, PUAEN10000650,
    PUAEN10001640, PUAEN20003120, SKMUS20006790, SKNMC20006350,
    SKNSH20007160, SMINT20030740, SMINT20035510, SMINT20089210,
    SPLEN20024930, SPLEN20040780, SPLEN20063250, SPLEN20181570,
    SPLEN20187490, TESTI20047370, TESTI20057880, TESTI20064530,
    TESTI20079980, TESTI20105130, TESTI20118460, TESTI20121040, TESTI20197290,
    THYMU10004280, THYMU20030460, THYMU20055460, THYMU20089900, THYMU20121040,
    THYMU20139160, THYMU20145990, TRACH20011010, TRACH20090060, UTERU20000230,
    UTERU20000950, UTERU20016580, UTERU20045200, UTERU20083020
  • These genes are involved in cancers.
  • Further, there is a method to search for genes involved in development and differentiation: the expression frequency analysis in which the expression levels of genes are compared between developing or differentiating tissues and/or cells and adult tissues and/or cells. The genes involved in tissue development and/or differentiation are genes participating in tissue construction and expression of function, and thus are useful genes, which are available for regenerative medicine aiming at convenient regeneration of injured tissues.
  • Search was carried out for the genes whose expression frequencies were different between developing and/or differentiating tissues and/or cells, and adult tissues and/or cells, by using the information of gene expression frequency based on the database of the nucleotide sequences of 770,546 clones shown above.
  • The result of comparative analysis of cDNA libraries derived from fetal brain (FCBBF, FEBRA or OCBBF) and adult brain (BRACE, BRALZ, BRAMY, BRAWH, BRCAN, BRCOC, BRHIP, BRSSN, BRSTN or BRTHA) showed that the genes whose expression levels were different between the two were the following clones (Tables 16 to 36).
    ADRGL20020290, ADRGL20021910, ADRGL20023920, ADRGL20046760,
    ADRGL20062330, ADRGL20079060, ASTRO20009140, ASTRO20020240,
    ASTRO20027330, ASTRO20047510, ASTRO20055530, ASTRO20055570,
    ASTRO20055930, ASTRO20090680, BGGI120010750, BNGH420021680,
    BNGH420023870, BNGH420059680, BNGH420074600, BNGH420086030,
    BRACE10000510, BRACE20003310, BRACE20007330, BRACE20009050,
    BRACE20014450, BRACE20017790, BRACE20018810, BRACE20025820,
    BRACE20038920, BRACE20050870, BRACE20051600, BRACE20051930,
    BRACE20052430, BRACE20052530, BRACE20054080, BRACE20054480,
    BRACE20054600, BRACE20055560, BRACE20057870, BRACE20059110,
    BRACE20059810, BRACE20061620, BRACE20062580, BRACE20063540,
    BRACE20065470, BRACE20066360, BRACE20068710, BRACE20069000,
    BRACE20069110, BRACE20069440, BRACE20079200, BRACE20079370,
    BRACE20097540, BRACE20098860, BRACE20099070, BRACE20194670,
    BRACE20196180, BRACE20196960, BRACE20200770, BRACE20200970,
    BRACE20204670, BRACE20205840, BRACE20207420, BRACE20212450,
    BRACE20215410, BRACE20216700, BRACE20216950, BRACE20219360,
    BRAMY10000980, BRAMY10001730, BRAMY20000210, BRAMY20000250,
    BRAMY20001510, BRAMY20003540, BRAMY20003880, BRAMY20005080,
    BRAMY20013670, BRAMY20016780, BRAMY20020440, BRAMY20021580,
    BRAMY20023390, BRAMY20023640, BRAMY20024790, BRAMY20027390,
    BRAMY20027990, BRAMY20028530, BRAMY20028620, BRAMY20035380,
    BRAMY20035830, BRAMY20036530, BRAMY20036810, BRAMY20038980,
    BRAMY20039290, BRAMY20040580, BRAMY20043520, BRAMY20043630,
    BRAMY20044920, BRAMY20045210, BRAMY20045420, BRAMY20047560,
    BRAMY20050640, BRAMY20050940, BRAMY20051820, BRAMY20052440,
    BRAMY20053910, BRAMY20055760, BRAMY20056620, BRAMY20056840,
    BRAMY20063750, BRAMY20072440, BRAMY20072870, BRAMY20073080,
    BRAMY20074110, BRAMY20074860, BRAMY20076100, BRAMY20076130,
    BRAMY20076530, BRAMY20083330, BRAMY20083820, BRAMY20089770,
    BRAMY20091230, BRAMY20093490, BRAMY20094890, BRAMY20095080,
    BRAMY20095570, BRAMY20096930, BRAMY20100680, BRAMY20102900,
    BRAMY20107980, BRAMY20111780, BRAMY20117670, BRAMY20118410,
    BRAMY20118490, BRAMY20120170, BRAMY20123400, BRAMY20124970,
    BRAMY20125170, BRAMY20125360, BRAMY20125550, BRAMY20126910,
    BRAMY20127310, BRAMY20127760, BRAMY20134050, BRAMY20135720,
    BRAMY20137360, BRAMY20139440, BRAMY20139750, BRAMY20143870,
    BRAMY20152510, BRAMY20155500, BRAMY20158550, BRAMY20159250,
    BRAMY20160020, BRAMY20173480, BRAMY20190550, BRAMY20194680,
    BRAMY20204270, BRAMY20206340, BRAMY20219620, BRAMY20221600,
    BRAMY20223010, BRAMY20225250, BRAMY20225320, BRAMY20227230,
    BRAMY20227860, BRAMY20227960, BRAMY20231150, BRAMY20234820,
    BRAMY20237190, BRAMY20238630, BRAMY20243120, BRAMY20244490,
    BRAMY20245140, BRAMY20245350, BRAMY20245760, BRAMY20251210,
    BRAMY20251750, BRAMY20263000, BRAMY20267780, BRAMY20269040,
    BRAMY20271140, BRAMY20274510, BRAMY20285650, BRAMY20287400,
    BRAWH20014590, BRAWH20020470, BRAWH20020600, BRAWH20021910,
    BRAWH20025490, BRAWH20026010, BRAWH20027250, BRAWH20030000,
    BRAWH20039640, BRAWH20040680, BRAWH20047790, BRAWH20050740,
    BRAWH20055240, BRAWH20055330, BRAWH20055780, BRAWH20058120,
    BRAWH20063010, BRAWH20078080, BRAWH20078620, BRAWH20080580,
    BRAWH20082550, BRAWH20082920, BRAWH20093040, BRAWH20093070,
    BRAWH20094900, BRAWH20095900, BRAWH20173790, BRAWH20174330,
    BRAWH20175230, BBAWH20175340, BRAWH20176850, BRAWH20182670,
    BRAWH20183170, BRAWH20185260, BRAWH20185270, BRAWH20186010,
    BRAWH20188750, BRAWH20190530, BRAWH20190550, BRAWH20191980,
    BRCAN10000760, BRCAN10001050, BRCAN10001680, BRCAN20001480,
    BRCAN20004180, BRCAN20005230, BRCAN20005410, BRCOC10000400,
    BRCOC20000470, BRCOC20003600, BRHIP10000720, BRHIP10001040,
    BRHIP20000210, BRHIP20003590, BRHIP20005060, BRSSN20001970,
    BRSSN20005610, BRSSN20005660, BRSSN20066440, BRSSN20074640,
    BRSSN20091190, BRSSN20092440, BRSSN20093890, CTONG20032930,
    CTONG20035240, CTONG20044870, CTONG20063930, CTONG20069320,
    CTONG20070720, CTONG20071040, CTONG20071680, CTONG20074170,
    CTONG20078340, CTONG20079590, CTONG20080140, CTONG20085210,
    CTONG20133720, CTONG20165750, CTONG20168240, CTONG20170940,
    CTONG20183430, CTONG20186370, CTONG20188080, FCBBF10000230,
    FCBBF10002200, FCBBF10004760, FCBBF20018680, FCBBF20020440,
    FCBBF20021110, FCBBF20023490, FCBBF20028980, FCBBF20029280,
    FCBBF20032930, FCBBF20033360, FCBBF20035430, FCBBF20035490,
    FCBBF20036360, FCBBF20038230, FCBBF20038950, FCBBF20041380,
    FCBBF20043730, FCBBF20054390, FCBBF20056580, FCBBF20059660,
    FCBBF20061310, FCBBF20066340, FCBBF20070800, FCBBF20070950,
    FCBBF30000010, FCBBF30001020, FCBBF30001100, FCBBF30001150,
    FCBBF30002270, FCBBF30002280, FCBBF30002330, FCBBF30003610,
    FCBBF30004340, FCBBF30004730, FCBBF30005180, FCBBF30005360,
    FCBBF30005500, FCBBF30019140, FCBBF30019180, FCBBF30019240,
    FCBBF30021900, FCBBF30022680, FCBBF30026580, FCBBF30029250,
    FCBBF30035570, FCBBF30042610, FCBBF30048420, FCBBF30053300,
    FCBBF30056980, FCBBF30062490, FCBBF30063990, FCBBF30068210,
    FCBBF30071500, FCBBF30072440, FCBBF30072480, FCBBF30074530,
    FCBBF30074620, FCBBF30075970, FCBBF30076310, FCBBF30078600,
    FCBBF30079770, FCBBF30080730, FCBBF30081000, FCBBF30085560,
    FCBBF30088700, FCBBF30089380, FCBBF30091010, FCBBF30091520,
    FCBBF30093170, FCBBF30095410, FCBBF30099490, FCBBF30100080,
    FCBBF30100120, FCBBF30100410, FCBBF30101240, FCBBF30101300,
    FCBBF30105080, FCBBF30105440, FCBBF30105860, FCBBF30106950,
    FCBBF30107290, FCBBF30107330, FCBBF30114180, FCBBF30114850,
    FCBBF30115230, FCBBF30115920, FCBBF30118670, FCBBF30118890,
    FCBBF30125460, FCBBF30125880, FCBBF30128420, FCBBF30129010,
    FCBBF30130410, FCBBF30130580, FCBBF30132050, FCBBF30132660,
    FCBBF30135890, FCBBF30136230, FCBBF30138000, FCBBF30142290,
    FCBBF30143550, FCBBF30145670, FCBBF30151190, FCBBF30153170,
    FCBBF30157270, FCBBF30161780, FCBBF30164510, FCBBF30166220,
    FCBBF30169280, FCBBF30169870, FCBBF30170710, FCBBF30171230,
    FCBBF30172330, FCBBF30173960, FCBBF30175350, FCBBF30177290,
    FCBBF30179180, FCBBF30179740, FCBBF30181730, FCBBF30194370,
    FCBBF30194550, FCBBF30195690, FCBBF30195700, FCBBF30197840,
    FCBBF30198670, FCBBF30201630, FCBBF30212210, FCBBF30215240,
    FCBBF30220050, FCBBF30222910, FCBBF30223110, FCBBF30223210,
    FCBBF30225930, FCBBF30228940, FCBBF30230610, FCBBF30236670,
    FCBBF30250980, FCBBF30255680, FCBBF30257370, FCBBF30259050,
    FCBBF30260210, FCBBF30260480, FCBBF30263080, FCBBF30266510,
    FCBBF30271990, FCBBF30275590, FCBBF30282020, FCBBF30285930,
    FCBBF30287940, FCBBF40000610, FCBBF40001920, FCBBF40005000,
    FCBBF50000410, FCBBF50000610, FCBBF50001650, FCBBF50003530,
    FCBBF50004950, FEBRA20005040, FEBRA20007820, FEBRA20018670,
    FEBRA20026820, FEBRA20027070, FEBRA20029620, FEBRA20031000,
    FEBRA20031150, FEBRA20031280, FEBRA20031810, FEBRA20035200,
    FEBRA20035240, FEBRA20038220, FEBRA20038330, FEBRA20038970,
    FEBRA20039070, FEBRA20039260, FEBRA20040230, FEBRA20040260,
    FEBRA20040290, FEBRA20040560, FEBRA20045380, FEBRA20046200,
    FEBRA20046280, FEBRA20046510, FEBRA20057010, FEBRA20063720,
    FEBRA20076200, FEBRA20078180, FEBRA20078800, FEBRA20080860,
    FEBRA20082660, FEBRA20083410, FEBRA20084750, FEBRA20086600,
    FEBRA20087550, FEBRA20088610, FEBRA20088810, FEBRA20090160,
    FEBRA20090220, FEBRA20091620, FEBRA20092760, FEBRA20093270,
    FEBRA20093280, FEBRA20095410, FEBRA20098040, FEBRA20099860,
    FEBRA20101410, FEBRA20108020, FEBRA20108580, FEBRA20115930,
    FEBRA20116650, FEBRA20121200, FEBRA20121950, FEBRA20141980,
    FEBRA20150420, FEBRA20151750, FEBRA20163980, FEBRA20170240,
    FEBRA20172230, FEBRA20173330, FEBRA20175020, FEBRA20175330,
    FEBRA20177800, FEBRA20180510, FEBRA20182030, FEBRA20187460,
    FEBRA20191720, HCHON20002650, HCHON20002710, HEART10001490,
    HLUNG20008460, HLUNG20011460, HLUNG20014590, HLUNG20015070,
    HLUNG20015180, HLUNG20020850, HLUNG20028110, HLUNG20031620,
    HLUNG20032460, HLUNG20033060, HLUNG20041590, HLUNG20045340,
    HLUNG20056560, HLUNG20068120, HLUNG20081390, HLUNG20083480,
    HLUNG20085210, HLUNG20094130, KIDNE20080690, KIDNE20084030,
    KIDNE20086660, KIDNE20094670, KIDNE20134130, KIDNE20138450,
    KIDNE20140870, KIDNE20149780, KIDNE20170400, KIDNE20173430,
    MESAN20021860, MESAN20030350, MESAN20034440, MESAN20038520,
    MESAN20045750, MESAN20067430, MESAN20089260, MESAN20095800,
    NT2NE20026200, NT2NE20033150, NT2NE20042550, NT2NE20045190,
    NT2NE20053950, NT2NE20061030, NT2NE20069580, NT2NE20082130,
    NT2NE20082600, NT2NE20088030, NT2NE20092950, NT2NE20095230,
    NT2NE20108420, NT2NE20111190, NT2NE20112210, NT2NE20141040,
    NT2NE20177210, NT2NE20181800, NT2RI20021200, NT2RP70001120,
    NT2RP70001730, NT2RP70012830, NT2RP70035110, NT2RP70057500,
    NT2RP70075300, NT2RP70087140, NT2RP70090870, NTONG20002230,
    NTONG20017620, NTONG20049180, NTONG20055200, OCBBF20000740,
    OCBBF20001780, OCBBF20005220, OCBBF20009820, OCBBF20011860,
    OCBBF20012520, OCBBF20016390, OCBBF20016810, OCBBF20109450,
    OCBBF20109780, OCBBF20110210, OCBBF20110730, OCBBF20111370,
    OCBBF20111600, OCBBF20112280, OCBBF20112320, OCBBF20113110,
    OCBBF20115360, OCBBF20116250, OCBBF20117220, OCBBF20118720,
    OCBBF20119810, OCBBF20120010, OCBBF20120950, OCBBF20121910,
    OCBBF20123200, OCBBF20142290, OCBBF20147070, OCBBF20152330,
    OCBBF20155030, OCBBF20156450, OCBBF20157970, OCBBF20160380,
    OCBBF20165900, OCBBF20165910, OCBBF20166890, OCBBF20166900,
    OCBBF20167290, OCBBF20170350, OCBBF20174580, OCBBF20174890,
    OCBBF20175360, OCBBF20176650, OCBBF20177540, OCBBF20177910,
    OCBBF20182060, OCBBF20185630, OCBBF20188280, OCBBF20191950,
    PLACE60054820, PLACE60056910, PLACE60061370, PLACE60064740,
    PLACE60073090, PLACE60120280, PLACE60132200, PLACE60150510,
    PLACE60154450, PLACE60157310, PLACE60162100, PROST10002150,
    PROST20014150, PROST20016760, PROST20024250, PROST20035170,
    PROST20035830, PROST20042700, PROST20045700, PROST20050390,
    PROST20054660, PROST20078710, PROST20094000, PROST20097310,
    PROST20097840, PROST20103820, PROST20114100, PROST20130320,
    PROST20151370, PUAEN10000650, PUAEN10001640, PUAEN20003120,
    SKNMC20006350, SKNSH10001010, SKNSH20007160, SKNSH20030640,
    SKNSH20094350, SMINT20000070, SMINT20002320, SMINT20030740,
    SMINT20039050, SMINT20045890, SMINT20047290, SMINT20048720,
    SMINT20056240, SMINT20077920, SMINT20088690, SMINT20089210,
    SMINT20089600, SMINT20094150, SPLEN20005160, SPLEN20005370,
    SPLEN20012450, SPLEN20024930, SPLEN20040780, SPLEN20048800,
    SPLEN20055600, SPLEN20057830, SPLEN20063250, SPLEN20071820,
    SPLEN20073880, SPLEN20076470, SPLEN20104690, SPLEN20114190,
    SPLEN20125230, SPLEN20135030, SPLEN20136700, SPLEN20175920,
    SPLEN20181570, SPLEN20183020, SPLEN20187490, SPLEN20193490,
    SPLEN20193790, SPLEN20197740, SPLEN20200070, SPLEN20200340,
    TESOP10000350, TESTI20005980, TESTI20030440, TESTI20030610,
    TESTI20031410, TESTI20035330, TESTI20047370, TESTI20050400,
    TESTI20050720, TESTI20053780, TESTI20057430, TESTI20057590,
    TESTI20057840, TESTI20057880, TESTI20059080, TESTI20061200,
    TESTI20062580, TESTI20063410, TESTI20064530, TESTI20066280,
    TESTI20067480, TESTI20071630, TESTI20079980, TESTI20081890,
    TESTI20089290, TESTI20090180, TESTI20105130, TESTI20106170,
    TESTI20121040, TESTI20150920, TESTI20169500, TESTI20193080,
    TESTI20215310, TESTI20221790, TESTI20245860, TESTI20252690,
    TESTI20254090, TESTI20261160, TESTI20262150, TESTI20274960,
    THYMU20007750, THYMU20009460, THYMU20009710, THYMU20019260,
    THYMU20028410, THYMU20030460, THYMU20031330, THYMU20043440,
    THYMU20044100, THYMU20044520, THYMU20049060, THYMU20055460,
    THYMU20055740, THYMU20071120, THYMU20078020, THYMU20089900,
    THYMU20091040, THYMU20104480, THYMU20120240, THYMU20139160,
    THYMU20143230, THYMU20150190, THYMU20157620, THYMU20176010,
    TKIDN10001920, TRACH20012490, TRACH20021000, TRACH20026640,
    TRACH20058000, TRACH20090060, TRACH20159390, UMVEN10001380,
    UTERU10001060, UTERU20000230, UTERU20000950, UTERU20026620, UTERU20041970,
    UTERU20065470, UTERU20079240, UTERU20083020, UTERU20089300, UTERU20089390,
    UTERU20095100, UTERU20102260, UTERU20103200, UTERU20127150, UTERU20128560
  • The result of comparative analysis of cDNA libraries derived from fetal heart (FEHRT) and adult heart (HEART) showed that the genes whose expression levels were different between the two were the following clones (Table 37).
    BRAMY20043630, BRAMY20072870, BRAMY20227860,
    BRAWH20093070, BRCAN10001680, FCBBF30053300,
    FEBRA20078800, FEBRA20090220, HCHON20000870,
    HEART10001420, HEART10001490, HEART20009590,
    HEART20019310, HEART20022200, HEART20031680,
    HEART20047640, HEART20063100, HEART20082570,
    HLUNG20083960, PLACE60088240, PLACE60120280,
    PROST20016760, PROST20035170, PROST20062820,
    PROST20127450, SKMUS20006790, SKMUS20008730,
    TESTI20270130
  • The result of comparative analysis of cDNA libraries derived from fetal kidney (FEKID) and adult kidney (KIDNE) showed that the genes whose expression levels were different between the two were the following clones (Table 38).
    ASTRO20009140, BGGI120010750, BRACE20054480, BRACE20062580,
    BRACE20219360, BRAMY20001510, BRAMY20003540, BRAMY20003880,
    BRAMY20043630, BRAMY20204270, CTONG20033750, CTONG20039370,
    CTONG20045500, FCBBF20023490, FEBRA20039260, FEBRA20040290,
    HEART10001490, HLUNG20041590, HLUNG20068120, HLUNG20072450,
    HLUNG20083960, KIDNE20011600, KIDNE20016360, KIDNE20024380,
    KIDNE20027980, KIDNE20080690, KIDNE20081170, KIDNE20083150,
    KIDNE20083620, KIDNE20084030, KIDNE20084040, KIDNE20084730,
    KIDNE20084800, KIDNE20086490, KIDNE20086660, KIDNE20086970,
    KIDNE20087880, KIDNE20088240, KIDNE20089870, KIDNE20091090,
    KIDNE20094260, KIDNE20094670, KIDNE20095530, KIDNE20133460,
    KIDNE20133880, KIDNE20134130, KIDNE20134890, KIDNE20137310,
    KIDNE20138450, KIDNE20140870, KIDNE20141120, KIDNE20141700,
    KIDNE20142680, KIDNE20142900, KIDNE20143200, KIDNE20147170,
    KIDNE20148080, KIDNE20149780, KIDNE20150730, KIDNE20152440,
    KIDNE20154330, KIDNE20154830, KIDNE20155980, KIDNE20157100,
    KIDNE20160360, KIDNE20160960, KIDNE20163710, KIDNE20165390,
    KIDNE20169180, KIDNE20170400, KIDNE20173150, KIDNE20173430,
    KIDNE20176030, KIDNE20181670, KIDNE20182540, KIDNE20186170,
    KIDNE20188630, KIDNE20189890, KIDNE20189960, KIDNE20191870, OCBBF20174890,
    PLACE60073090, PLACE60181870, PROST20016760, PUAEN10000650, SKNMC20006350,
    SPLEN20017610, SPLEN20063250, SPLEN20126110, SPLEN20135030, TESTI20061200,
    TESTI20262150, THYMU10004280, THYMU20139160, TRACH20011010
  • The result of comparative analysis of cDNA libraries derived from fetal lung (FELNG) and adult lung (HLUNG) showed that the genes whose expression levels were different between the two were the following clones (Table 39).
    BRAMY20001510, BRAMY20043630, BRAMY20204270, BRAMY20227860,
    CTONG20029030, CTONG20168460, CTONG20186290, FEBRA20039260,
    FEBRA20078800, FEBRA20163980, HCHON20000870, HLUNG20008460,
    HLUNG20009260, HLUNG20009550, HLUNG20010130, HLUNG20011260,
    HLUNG20011440, HLUNG20011460, HLUNG20012140, HLUNG20014590,
    HLUNG20015070, HLUNG20015180, HLUNG20020500, HLUNG20020850,
    HLUNG20021450, HLUNG20023030, HLUNG20024050, HLUNG20025620,
    HLUNG20028110, HLUNG20029420, HLUNG20029490, HLUNG20030420,
    HLUNG20030490, HLUNG20030610, HLUNG20031620, HLUNG20032460,
    HLUNG20033060, HLUNG20033310, HLUNG20033350, HLUNG20034970,
    HLUNG20037140, HLUNG20037160, HLUNG20037780, HLUNG20038330,
    HLUNG20041540, HLUNG20041590, HLUNG20042730, HLUNG20045340,
    HLUNG20047070, HLUNG20050760, HLUNG20051330, HLUNG20052300,
    HLUNG20054790, HLUNG20055240, HLUNG20056560, HLUNG20057380,
    HLUNG20059240, HLUNG20060670, HLUNG20063700, HLUNG20065700,
    HLUNG20065990, HLUNG20067810, HLUNG20068120, HLUNG20069350,
    HLUNG20070410, HLUNG20072100, HLUNG20072190, HLUNG20072450,
    HLUNG20074330, HLUNG20079310, HLUNG20081390, HLUNG20081530,
    HLUNG20082350, HLUNG20083330, HLUNG20083480, HLUNG20083840,
    HLUNG20083960, HLUNG20084790, HLUNG20085210, HLUNG20088750,
    HLUNG20092530, HLUNG20093030, HLUNG20094130, KIDNE20142900,
    PROST20016760, PROST20052850, SKNMC20006350, SMINT20035050, SPLEN20012450,
    TESTI20057590, TESTI20061200, TESTI20067480, TESTI20116050, THYMU10004280,
    THYMU20010180, THYMU20139160, TRACH20011010, UTERU20016580, UTERU20127030
  • These genes are involved in regeneration of tissues and/or cells.
    • EXAMPLE 8 Expression Frequency Analysis by PCR
  • Specific PCR primers were prepared based on the full-length nucleotide sequences, and the expression frequency was analyzed by the ATAC-PCR method (Adaptor-tagged competitive PCR method: Nucleic Acids Research 1997, 25 (22): 4694-4696; “DNA Micro-array and Advanced PCR Techniques”, Cell Technology, supplement, Eds., Muramatsu and Nawa (Shujunsha, 2000): 104-112). Inflammation-related genes can be identified by revealing the genes whose expression levels are altered depending on the presence of an inflammation-inducing factor. Then, by using THP-1 cell line, which is a cell line of monocyte line, and TNF-α, which is an inflammation-inducing factor, suitable for this system, the genes whose expression levels are altered depending on the presence of the factor were searched for by the system.
  • THP-1 cell line (purchased from DAINIPPON PHARMACEUTICAL) was cultured to be confluent in RPMI1640 medium (sigma) containing 5% fetal calf serum (GIBCO BRL). Then, the medium was changed with the medium containing 10 ng/ml TNF-α (human recombinant TNF-α; Pharmacia Biotech), and the culture was continued at 37° C. under 5% CO2. After three hours, the cells were harvested, and total RNA was extracted from them by using ISOGEN reagent (Nippon Gene). The extraction was carried out according to the method in the document attached to ISOGEN reagent. In addition, total RNA was also extracted from the cells cultured without stimulation of TNF-α.
  • The genes involved in the onset of gastritis and gastroduodenal ulcer induced by the infection of Helicobacter pylori to the epithelia of stomach can be identified by revealing the genes whose expression levels are altered depending on co-culturing the cells with Helicobacter pylori. A recent study has suggested that various substances derived from Helicobacter pylori trigger the inflammation reaction. In particular, the members belonging to the family of genes called “cag pathogenicity island (cag PAI)” contribute to the activation of the NF-κB pathway (Gastroenterology 2000, 119: 97-108). Further, it has been found that cag PAI is involved in the onset of gastritis and the like by the study using an animal model (Journal of Experimental Medicine 2000, 192:1601-1610). Then, by using co-culture of a gastric cancer cell line with cag PAI-positive Helicobacter pylori (TN2), suitable for this system, the genes whose expression levels are altered depending on the presence of Helicobacter pylori were searched for by the system. Further, in order to study the involvement of cag PAI in the alterations of gene expression levels depending on the co-culture with Helicobacter pylori, the altered expression levels were compared between the cells co-cultured with a strain of Helicobacter pylori (TN2ΔcagE strain) having a mutation in cagE, which is one of the cag PAI genes, and the cag PAI-positive strain (TN2).
  • A gastric cancer cell line MKN45 (provided by the Cell Bank, RIKEN GENE BANK, The Institute of Physical and Chemical Research) was cultured to be confluent in RPMI1640 medium (sigma) containing 10% fetal calf serum (GIBCO BRL). Then, the medium was changed with the medium containing 100-fold excess (in terms of the number of cells or the number of colonies) of Helicobacter pylori (cag PAI positive strain (TN2) and cagE mutant (TN2ΔcagE): both were provided by Prof. Omata, Faculty of Medicine, The University of Tokyo), as compared with the number of the cancer cells. The culture was continued at 37° C. under 5% CO2. After three hours, the cells were harvested, and total RNA was extracted from them by using ISOGEN reagent (Nippon Gene). The extraction was carried out according to the method in the document attached to ISOGEN reagent. In addition, total RNA was also extracted from the cells cultured without Helicobacter pylori.
  • The analysis by the ATAC-PCR method was carried out basically according to “DNA Micro-array and Advanced PCR Techniques”, Cell Technology, supplement (Genome Science Series 1, Eds., Muramatsu and Nawa (Shujunsha, 2000): 104-112). Adapter ligation to the internal standard sample (sample to make the calibration curve for the clone of interest) and test sample was carried out in the two separate reaction systems indicated below. The combination of 6 types of adapters (AD-1, AD-2, AD-3, AD-4, AD-5 and AD-6: see the sequences indicated below) and the samples are as follows.
  • Reaction System A
    • AD1; internal standard, 10-fold
    • AD2; THP-1 cells, unstimulated
    • AD3; internal standard, 3-fold
    • AD4; THP-1 cells, TNF-α stimulation for one hour
    • AD5; THP-1 cells, TNF-α stimulation for three hours
    • AD6; internal standard, 1-fold
      Reaction System B
    • AD1; internal standard, 1-fold
    • AD2; MKN45 cells, unstimulated
    • AD3; internal standard, 3-fold
    • AD4; MKN45 cells, co-cultured with TN2 (Helicobacter pylori)
    • AD5; internal standard, 10-fold
    • AD6; MKN45 cells, co-cultured with TN2ΔcagE (cagE gene mutant)
  • Adapter Sequences:
    AD1;
    SEQ ID NO: 3941
    5′-GTACATATTGTCGTTAGAACGCG-3′//
    SEQ ID NO: 3942
    3′-CATGTATAACAGCAATCTTGCGCCTAG-5′//
    AD2;
    SEQ ID NO: 3943
    5′-GTACATATTGTCGTTAGAACGCGACT-3′//
    SEQ ID NO: 3944
    3′-CATGTATAACAGCAATCTTGCGCTGACTAG-5′//
    AD3;
    SEQ ID NO: 3945
    5′-GTACATATTGTCGTTAGAACGCGCATACT-3′//
    SEQ ID NO: 3946
    3′-CATGTATAACAGCAATCTTGCGCGTATGACTAG-5′//
    AD4;
    SEQ ID NO: 3947
    5′-GTACATATTGTCGTTAGAACGCGATCCATACT-3′//
    SEQ ID NO: 3948
    3′-CATGTATAACAGCAATCTTGCGCTAGGTATGACTAG-5′//
    AD5;
    SEQ ID NO: 3949
    5′-GTACATATTGTCGTTAGAACGCGTCAATCCATACT-3′//
    SEQ ID NO: 3950
    3′-CATGTATAACAGCAATCTTGCGCAGTTAGGTATGACTAG-5′//
    AD6;
    SEQ ID NO: 3951
    5′-GTACATATTGTCGTTAGAACGCGTACTCAATCCATACT-3′//
    SEQ ID NO: 3952
    3′-CATGTATAACAGCAATCTTGCGCATGAGTTAGGTATGACTAG-5′//
  • The internal standard sample used for this assay was a mixture of total RNAs from tissues (or culture cells; all from UNITECH) of brain, kidney, NT2, testis, thymus, and trachea. RNA was prepared according to the standard method.
  • The sequences of primers specific to the genes and the names of clones of interest in the analysis are as follows. The gene specific primers were designed to produce the PCR products of 70 to 200 bp, which are derived from the adapter-containing cDNA. The sequence of adapter-specific primer (labeled with fluorescence (FAM)) used in the competitive PCR was GTACATATTGTCGTTAGAACGC (22 nucleotides; SEQ ID NO: 3953). PCR was basically carried out with a cycling profile of preheating at 94° C. for 3 minutes, and 35 or 40 cycles of denaturation at 94° C. for 30 seconds/annealing at 50° C. for 60 seconds/extension at 72° C. for 90 seconds.
  • The Nucleotide Sequences of Clone Specific Primers Used in the Experiments
  • Clone name, primer sequence and SEQ ID NO are indicated below in this order. Each is demarcated by a double slash mark (//).
    ADRGL20036380//CTACTCAAGGACAGCCACAC// SEQ ID NO: 3954
    ASTRO20045840//GGATGTAGTGGGAAACAATG// SEQ ID NO: 3955
    ASTRO20055930//TGCTTTTCATTCTCCTTAGT// SEQ ID NO: 3956
    ASTRO20088950//TACGTGCTCATTTACTTGGT// SEQ ID NO: 3957
    BNGH420052350//GCCAGTTTCTTTATGATTGA// SEQ ID NO: 3958
    BRACE20052530//AATGACTTCGTTAGGATGCC// SEQ ID NO: 3959
    BRACE20054080//GCTGTTGACTTCATTTGGAA// SEQ ID NO: 3960
    BRAMY20003880//TTGGTACTTATTCTGAGGCA// SEQ ID NO: 3961
    BRAMY20027390//GATTTTAGTGAAACATGCCA// SEQ ID NO: 3962
    BRAMY20028530//TTAAAACTGAGGACATTCTG// SEQ ID NO: 3963
    BRAMY20035380//AGAGAAGGCAGTCTAGCTTA// SEQ ID NO: 3964
    BRAMY20036530//AGGGTATGGTAACTTCTGCA// SEQ ID NO: 3965
    BRAMY20050940//AAAGGAGGGACTAGAAAACT// SEQ ID NO: 3966
    BRAMY20072440//ACTATGACGAGGGAACAAGA// SEQ ID NO: 3967
    BRAMY20096930//GAGGAGAACACAAGTATGGT// SEQ ID NO: 3968
    BRAMY20118410//AAGGTCACTTCTAAACACAC// SEQ ID NO: 3969
    BRAMY20237190//GGAGTGATTCAGGAGATGTG// SEQ ID NO: 3970
    BRAWH20055330//GCAACAGAGACTTTATTGGT// SEQ ID NO: 3971
    BRAWH20078620//GAGAGACTTATCACAGCCAT// SEQ ID NO: 3972
    BRAWH20190530//ATGGGATTCTGTGACTTCTC// SEQ ID NO: 3973
    BRCAN20001480//CAGCAACAGTAATGGGAATT// SEQ ID NO: 3974
    BRHIP10000720//AGGTTAGGATTTCTTTAGCA// SEQ ID NO: 3975
    BRHIP10001040//TACTTGGAGACAACAGGGAG// SEQ ID NO: 3976
    BRHIP20000210//GTGTTTGTGGGCATAGACAT// SEQ ID NO: 3977
    BRSSN20001970//AATGTATTCAGTTCCTTTCC// SEQ ID NO: 3978
    BRSSN20091190//GTGTCATCACTAGCACCAAG// SEQ ID NO: 3979
    CD34C20001750//TGGACTTAGGGACCTGACTC// SEQ ID NO: 3980
    CTONG20078340//CTCTTTACCTAGTTTGGTCA// SEQ ID NO: 3981
    CTONG20079590//TACTTATTTTCACAGGGGCC// SEQ ID NO: 3982
    CTONG20083980//CAGCATTTTCCTATATAGCC// SEQ ID NO: 3983
    CTONG20085210//CCAGAAGAGTAGCAAGAATT// SEQ ID NO: 3984
    DFNES20063460//CTATTTTAACCCCTGCCCTC// SEQ ID NO: 3985
    DFNES20072990//GGAGGTATCTATTAGGGTGA// SEQ ID NO: 3986
    FCBBF20029280//GACTGAGATGAACTGGAAGA// SEQ ID NO: 3987
    FCBBF20032930//TCACAATACAGTCCCCTAGT// SEQ ID NO: 3988
    FCBBF20036360//ATTTGTATCACTTTGGTGCA// SEQ ID NO: 3989
    FCBBF30022680//CTCCAGAAAATGCATGAATC// SEQ ID NO: 3990
    FCBBF30078600//CTTCAACAGTGCTTTTCCTT// SEQ ID NO: 3991
    FCBBF30105080//CTGTGCACCCACTCTTTATT// SEQ ID NO: 3992
    FCBBF30169870//TCCAGTATTTTCCACTTTGA// SEQ ID NO: 3993
    FCBBF30225930//ACTATTTTATGGTCACGGCC// SEQ ID NO: 3994
    FCBBF50000610//AGTTAACGTATCTGGCAAAG// SEQ ID NO: 3995
    FEBRA20007820//GTTTCTCACTGTCCTGTTTT// SEQ ID NO: 3996
    FEBRA20031280//ACTATTTTATGGTCACGGCC// SEQ ID NO: 3997
    FEBRA20031810//TGCAATCATCTCTGTATCCC// SEQ ID NO: 3998
    FEBRA20039260//GTCAGAACCCACTTCACATC// SEQ ID NO: 3999
    FEBRA20046280//TCTCTGTCCTGTTGTCTAAG// SEQ ID NO: 4000
    FEBRA20084750//TTAGCATGTACTGGGAAAGC// SEQ ID NO: 4001
    FEBRA20182030//AAAACACAAAATGACACCCC// SEQ ID NO: 4002
    HLUNG20041540//AAAGTTCCTCTGCATTCACC// SEQ ID NO: 4003
    HLUNG20092530//TTTTCATCCCAGAGTTATTA// SEQ ID NO: 4004
    KIDNE20084030//AGGGAATAACTTGCAGCTTG// SEQ ID NO: 4005
    KIDNE20084800//GTAATGTAGGGAGACTGCCG// SEQ ID NO: 4006
    KIDNE20134130//AATCCCCTCTTTTGTCTCAT// SEQ ID NO: 4007
    KIDNE20182540//ACAGATAGCCTGGATTGAAA// SEQ ID NO: 4008
    KIDNE20186170//TTGTATCTGAGCTGGGGTTT// SEQ ID NO: 4009
    KIDNE20188630//CCCTACATATCTCTACCCAT// SEQ ID NO: 4010
    LIVER20007750//TATTTAGAAACGCAGACCCC// SEQ ID NO: 4011
    MESAN20021220//TAGAAGTCAACAAAAGGCAC// SEQ ID NO: 4012
    MESAN20084150//TCCATAAGGCACAGATTTGA// SEQ ID NO: 4013
    NT2NE20059210//ATAATGACAATGCCAGTAGT// SEQ ID NO: 4014
    NT2NE20082130//TGAGGTACATCCAAATTAAA// SEQ ID NO: 4015
    NT2NE20092950//ATGATTACTCGGTTTCCAGA// SEQ ID NO: 4016
    NT2RP70031070//CAGTTAGTAGACAGACGGGG// SEQ ID NO: 4017
    OCBBF20012520//TCTGCCTGTAGTTGCCATTA// SEQ ID NO: 4018
    OCBBF20110210//AGGTGATAGGACTTTGTGCC// SEQ ID NO: 4019
    OCBBF20110730//TTAGATGCTCCCTAAGGTCC// SEQ ID NO: 4020
    OCBBF20155030//GCTAAAATCGTGCATCTGTA// SEQ ID NO: 4021
    OCBBF20165900//AGTTTTGTATCTCCTTGTCA// SEQ ID NO: 4022
    OCBBF20170350//TAAGATGGAGTTCAGGGGAG// SEQ ID NO: 4023
    OCBBF20176650//GCACACAGGCAAATTCTAGT// SEQ ID NO: 4024
    PLACE60006300//TTCTGTAATAAGGGCTGTCA// SEQ ID NO: 4025
    PLACE60061370//TGTTCACAAATGGCATAAAA// SEQ ID NO: 4026
    PROST20011160//CTACTAACTCAACCACGCAT// SEQ ID NO: 4027
    PROST20041460//CCATTTACGTCACCTCTCTG// SEQ ID NO: 4028
    PROST20065100//ACTATTTTATGGTCACGGCC// SEQ ID NO: 4029
    PROST20075280//ACGTTGACTCTGATAGCCTG// SEQ ID NO: 4030
    PROST20106060//AATTCTTTTGACATTGCTTG// SEQ ID NO: 4031
    PROST20110120//GATAAATTCAGCAAGAGCAT// SEQ ID NO: 4032
    SKMUS20091900//AACTCTGCACTCCATAACTG// SEQ ID NO: 4033
    SMINT20024140//AAGCCTCTAAAAGTCAACAC// SEQ ID NO: 4034
    SMINT20092160//TTAAACAAGTGAGCCTCAGA// SEQ ID NO: 4035
    SPLEN20040780//TTTCCTGTTTGGTTAGTTTT// SEQ ID NO: 4036
    SPLEN20110860//CTGACGGAAAACTTCTAATT// SEQ ID NO: 4037
    SPLEN20177400//ATATCTGGTTGTTGGGTTTT// SEQ ID NO: 4038
    TESTI20038240//GTCTGTCTTGATGGATTGGA// SEQ ID NO: 4039
    TESTI20043130//AACTATCAGACTGCAAGAGC// SEQ ID NO: 4040
    TESTI20046540//GGTAGCCAATAGCAAACAGG// SEQ ID NO: 4041
    TESTI20047370//ACGTTGCATAATCCTCAGTC// SEQ ID NO: 4042
    TESTI20057200//AGTCCCAGTCTCTAGTTCGG// SEQ ID NO: 4043
    TESTI20057590//ACATTTTGGTATTGACACTT// SEQ ID NO: 4044
    TESTI20113940//GTCAGTCCACCTTACTCTTT// SEQ ID NO: 4045
    TESTI20149880//CAAACGATTACGACACAAAA// SEQ ID NO: 4046
    TESTI20151800//CGTTCCTCAGGTAGCAAGAT// SEQ ID NO: 4047
    TESTI20173050//ACATGGCTGAAGGTGATTTT// SEQ ID NO: 4048
    TESTI20198600//TTTAGAAACATTGGCATCAG// SEQ ID NO: 4049
    TESTI20257910//CTGCCTAGAGTAGAACAAAA// SEQ ID NO: 4050
    TESTI20262940//CTCCCAATCTCAAACACAAG// SEQ ID NO: 4051
    THYMU20046770//CTTCTGCCGAGTTTGTGTAA// SEQ ID NO: 4052
    THYMU20058550//GATGCTGAGAAGGTGTTAGT// SEQ ID NO: 4053
    THYMU20062520//AGTCTCAGGATGGGTAAAGG// SEQ ID NO: 4054
    THYMU20062770//AGAGTTAAGAACCGAGGGAT// SEQ ID NO: 4055
    THYMU20078240//CAAGCCAGGGAGATAGACAT// SEQ ID NO: 4056
    THYMU20150190//TACTACAATGTGGGCTACGG// SEQ ID NO: 4057
    TRACH20125620//CCACATTGTAAACAGTCCTT// SEQ ID NO: 4058
    TRACH20149740//AGATACATTTTCCGTCAAGC// SEQ ID NO: 4059
    TRACH20190460//CCAGAAGAGTAGCAAGAATT// SEQ ID NO: 4060
    UTERU20045200//ATTCAACTAAAACAAAGCTG// SEQ ID NO: 4061
    UTERU20064120//ACCCAGAAAAGAGATGAGAA// SEQ ID NO: 4062
    UTERU20103200//CTGTTCCTGGCAAATAAGAG// SEQ ID NO: 4063
    ADRGL20046760//ATGTGAAGGAATGATGTACT// SEQ ID NO: 4064
    ASTRO20055530//GAATAATGAAGGGGACCAGA// SEQ ID NO: 4065
    BRAMY20076130//CCTTTCATGTCTCAGTATTT// SEQ ID NO: 4066
    CTONG20170940//ATACGTCAGAGGACACATGC// SEQ ID NO: 4067
    FCBBF20033360//TCCGTAGCAGTAGAAACATC// SEQ ID NO: 4068
    FCBBF30257370//CAGGTATGCTTGGAGTTTCA// SEQ ID NO: 4069
    FCBBF5000165O//CGTGATTAGGAAGGGACAGT// SEQ ID NO: 4070
    FEBRA20040290//CCCAAGAACGAAACAAAACT// SEQ ID NO: 4071
    FEBRA20063720//AATAATGCCCACCTATAAAA// SEQ ID NO: 4072
    FEBRA20098040//GAGGGGAATTGTCAGTACAC// SEQ ID NO: 4073
    FEBRA20108580//TCATTTTGTCTAGTGCCCAT// SEQ ID NO: 4074
    MESAN20021860//ACACATTCCCATCAATAGGT// SEQ ID NO: 4075
    MESAN20067430//AGCTAAGGAGGTTTTCACAT// SEQ ID NO: 4076
    NT2NE20045190//GGAATATGTTGGGCTAGTTA// SEQ ID NO: 4077
    PROST20016760//AACTTCATCCATTCCAACTG// SEQ ID NO: 4078
    SKNSH2000716O//TTAAACCAACATTGAGGAAA// SEQ ID NO: 4079
    SMINT20006020//CTTGGTTGTCCCCTTTCTAG// SEQ ID NO: 4080
    TESTI20059370//GGCTGACTTTTCTCCTACAG// SEQ ID NO: 4081
    TESTI20103690//CCACTTTATTTCTCCTCCCT// SEQ ID NO: 4082
    TESTI20254480//GTGGACACAACTTGCTTTAC// SEQ ID NO: 4083
    THYMU10004280//GAGAGTCTGCCTAGCTGTGT// SEQ ID NO: 4084
    THYMU20030460//GCCCATGTGAGTAGGTGTAG// SEQ ID NO: 4085
    TRACH20090060//AGGGCCAACTTAAATCTCTG// SEQ ID NO: 4086
    UTERU20041970//GATAAACCCCAAACATGAAA// SEQ ID NO: 4087
    BRAMY20125360//GACAGACTAAAACGTTGAGC// SEQ ID NO: 4088
    OCBBF20142290//CCAAGGAGAGTCAGTGACAG// SEQ ID NO: 4089
    SKMUS20006790//TTCAAAAGCAGAGACTCCCT// SEQ ID NO: 4090
    TESTI20030610//TGAACTCAGTACCAGGCTTG// SEQ ID NO: 4091
    UTERU20026620//GAGATTCCCTAGTGGTGGTT// SEQ ID NO: 4092
  • The result of expression frequency analysis is shown in Table 40. The clones not shown in the table contain clones whose expression levels could not be measured because the levels were too low or the sizes of the PCR products were different from the expected. It was confirmed that the expression levels of IL-8 gene used as a positive control gene were elevated.
  • The result obtained by the search for the genes whose expression levels were altered depending on the presence of TNF-α in culturing THP-1 cell, which is a human monocyte cell line, showed that the clones whose expression levels were elevated by twofold or more one or three hours after the stimulation (the clones whose expression levels were 0.1 or lower both before and after the stimulation were excluded), were
    ASTRO20055530, ASTRO20055930, ASTRO20088950, BRAMY20027390,
    BRAMY20076130, BRAMY20118410, BRAMY20125360, BRAMY20237190,
    BRCAN20001480, BRHIP10000720, CD34C20001750, CTONG20078340,
    CTONG20085210, DFNES20063460, FCBBF20029280, FCBBF20033360,
    FCBBF30078600, FEBRA20007820, FEBRA20031280, FEBRA20031810,
    FEBRA20040290, HLUNG20041540, HLUNG20092530, MESAN20021860,
    MESAN20067430, MESAN20084150, NT2NE20092950, NT2RP70031070,
    OCBBF20012520, OCBBF20142290, OCBBF20165900, OCBBF20170350,
    OCBBF20176650, PLACE60006300, PROST20011160, PROST20106060,
    SPLEN20040780, SPLEN20110860, SPLEN20177400, TESTI20030610, TESTI20043130,
    TESTI20059370, TESTI20254480, THYMU10004280, THYMU20030460, THYMU20062520,
    THYMU20078240, THYMU20150190, TRACH20090060, TRACH20125620, UTERU20026620,
    UTERU20045200, UTERU20064120, UTERU20103200.
  • On the other hand, in particular cases where the expression levels were relatively high in the unstimulated cells (the relative value was 1 or higher), the clones whose expression levels were decreased by twofold or more by the TNF-α stimulation (the clones whose expression levels were increased 1 or 3 hours after the stimulation were excluded) were
    BNGH420052350, BRACE20052530, BRAMY20003880,
    CTONG20170940, FCBBF30022680, FCBBF30225930,
    FCBBF30257370, FEBRA20046280, KIDNE20084030,
    KIDNE20188630, NT2NE20082130, OCBBF20110210,
    PLACE60061370, PROST20041460, PROST20075280,
    PROST20110120, SMINT20006020, TESTI20046540,
    TESTI20057200, TESTI20113940, TESTI20257910,
    TESTI20262940, TRACH20149740.
  • These clones were thus revealed to be involved in the inflammation reaction induced by TNF-α.
  • The result obtained by the search for the genes whose expression levels were altered depending on co-culturing gastric cancer cell line MKN45 with cag PAI positive Helicobacter pylori (TN2), showed that the clones whose expression levels were elevated by twofold or more (the clones whose expression levels were 0.1 or lower both before and after the stimulation were excluded), were
    BRAMY20028530, BRAMY20035380, OCBBF20170350,
    PROST20011160, SKMUS20091900, SPLEN20040780,
    THYMU20078240, TRACH20190460, UTERU20045200,
    UTERU20064120, ASTRO20055530, CTONG20170940,
    FEBRA20040290, MESAN20067430, PROST20016760,
    THYMU10004280, TRACH20090060, UTERU20041970,
    OCBBF20142290, TESTI20030610.
  • Of these clones, the expression levels of BRAMY20035380, SKMUS20091900, SPLEN20040780, UTERU20064120, CTONG20170940, OCBBF20142290, TESTI20030610 were not increased by the co-culture with the cagE mutant (TN2ΔcagE). There may be the possibility that the expression levels of the 7 clones are altered via the NF-κB pathway. Among them, the expression levels of OCBBF20142290, SPLEN20040780, TESTI20030610, UTERU20064120 were also increased when human monocyte cell line THP-1 was stimulated with TNF-α.
  • On the other hand, in particular cases where the expression levels were relatively high in the unstimulated cells (the relative value was 1 or higher), the clones whose expression levels were decreased by twofold or more in the presence of Helicobacter pylori were
    ASTRO20088950, BRACE20052530, BRAMY20003880,
    BRAMY20027390, BRAMY20036530, BRAMY20118410,
    BRHIP20000210, FCBBF20032930, FCBBF30022680,
    FCBBF30169870, FEBRA20182030, KIDNE20182540,
    LIVER20007750, MESAN20021220, NT2NE20059210,
    NT2NE20082130, OCBBF20155030, PROST20065100,
    PROST20075280, SPLEN20110860, TESTI20057200,
    TESTI20113940, TESTI20149880, TESTI20151800,
    TESTI20198600, TESTI20257910, THYMU20046770,
    THYMU20058550, THYMU20150190, FCBBF20033360,
    FCBBF30257370, FEBRA20098040, SMINT20006020.
  • These clones are involved in gastritis or gastroduodenal ulcer.
    TABLE 3
    Clone ID CD34C D30ST D60ST D90ST
    ASTRO20010290 0 55.437 0 0
    BRAMY20036530 0 33.144 0 0
    BRAMY20043630 0 0 0 13.575
    BRAMY20089770 0 0 0 63.803
    BRAMY20190550 0 0 0 31.089
    CD34C20001750 100 0 0 0
    FCBBF20066340 0 0 0 76.503
    FEBRA20040290 0 0 0 14.912
    HLUNG20015180 0 0 0 8.491
    HLUNG20041590 0 0 0 18.349
    HLUNG20052300 0 36.241 0 0
    KIDNE20084040 0 0 0 65.916
    MESAN20021860 0 0 0 56.046
    MESAN20027240 0 0 0 33.731
    NTONG20055200 0 0 0 19.731
    PROST20016760 0 0 0 15.442
    PUAEN10001640 0 34.074 0 0
    SMINT20006020 0 7.702 0 9.021
    SMINT20028840 0 68.605 0 0
    SMINT20035050 0 9.417 0 11.029
    SPLEN20181570 81.506 0 0 0
    TESTI20064530 0 0 77.29 0
    TESTI20210030 0 0 0 90.471
    THYMU20029830 0 42.091 0 0
    THYMU20139160 0 0 0 3.486
    TRACH20051590 0 0 0 75.217
  • TABLE 4
    Clone ID NT2RM NT2RP NT2RI NT2NE
    ADRGL20023920 0 6.69 0 0
    ASTRO20009140 0 0 13.389 0
    BNGH420077980 0 0 20.754 0
    BNGH420086030 0 0 0 13.322
    BRACE20062580 0 0 3.585 2.717
    BRACE20079370 0 0 9.312 14.111
    BRACE20215410 0 0 27.196 0
    BRAMY20003540 0 0 3.208 4.861
    BRAMY20043630 0 0 2.408 0
    BRAMY20076130 0 0 6.601 0
    BRAMY20095080 0 0 25.606 0
    BRAMY20227860 0 2.798 6.17 3.596
    BRAWH20082550 0 0 0 9.738
    BRHIP10001040 0 0 0 2.323
    BRSSN20005610 0 22.393 0 0
    CTONG20027660 0 0 50.642 0
    CTONG20044230 0 0 50.642 0
    CTONG20066110 0 0 19.131 0
    CTONG20079590 0 14.297 29.102 0
    CTONG20084660 0 0 2.553 0
    CTONG20133720 0 8.861 0 9.111
    CTONG20165750 0 9.056 0 0
    CTONG20188080 0 10.319 0 0
    FCBBF20023490 0 7.376 0 7.583
    FCBBF20033360 0 0 5.015 0
    FCBBF20059660 0 0 0 66.235
    FCBBF20070950 0 0 15.367 0
    FCBBF30004340 0 0 0 8.778
    FCBBF30095410 0 79.235 0 0
    FCBBF30125460 0 0 0 9.321
    FCBBF30179180 0 0 56.418 0
    FCBBF30236670 0 1.325 4.494 2.724
    FCBBF30257370 0 19.522 0 0
    FCBBF50000610 0 0 56.418 0
    FCBBF50001650 0 0 0 22.181
    FEBRA20038330 0 16.124 0 0
    FEBRA20039260 0 7.162 2.43 0
    FEBRA20063720 0 12.258 0 0
    FEBRA20090220 0 4.602 3.122 4.732
    FEBRA20150420 0 0 33.26 0
    HEART10001490 0 0 9.27 0
    HLUNG20032460 0 0 0 21.278
    HLUNG20041590 0 0 0 4.932
    KIDNE20089870 0 0 0 4.145
    MESAN20016270 0 0 39.208 0
    MESAN20021860 0 0 0 7.532
    MESAN20060430 0 0 24.385 0
    MESAN20067430 0 0 0 9.568
    NT2NE20018740 0 0 0 100
    NT2NE20018890 0 0 0 100
    NT2NE20021860 0 0 0 100
    NT2NE20026200 0 0 0.808 2.449
    NT2NE20026510 0 0 0 100
    NT2NE20028700 0 0 0 22.223
    NT2NE20033150 0 0 0 50.133
    NT2NE20037050 0 0 0 100
    NT2NE20038870 0 0 0 100
    NT2NE20039210 0 0 0 100
    NT2NE20042550 0 0 0 59.083
    NT2NE20045190 0 0 5.05 15.306
    NT2NE20047870 0 0 0 100
    NT2NE20053230 0 0 0 100
    NT2NE20053950 0 20.953 0 21.544
    NT2NE20059210 0 0 0 100
    NT2NE20059680 0 0 0 100
    NT2NE20060750 0 0 0 100
    NT2NE20061030 0 39.18 0 40.284
    NT2NE20062880 0 0 0 100
    NT2NE20064780 0 0 0 100
    NT2NE20066590 0 0 0 100
    NT2NE20069580 0 0 0 59.083
    NT2NE20070520 0 0 0 100
    NT2NE20073650 0 0 0 100
    NT2NE20077250 0 0 0 100
    NT2NE20077270 0 0 0 100
    NT2NE20077860 0 0 0 100
    NT2NE20079670 0 0 0 100
    NT2NE20080770 0 0 0 100
    NT2NE20082130 0 0 0 38.09
    NT2NE20082600 0 0 0 66.235
    NT2NE20086070 0 0 0 100
    NT2NE20087270 0 0 0 100
    NT2NE20087850 0 0 0 100
    NT2NE20088030 0 0 0 60.425
    NT2NE20092950 0 20.298 0 20.87
    NT2NE20095230 0 0 0 55.188
    NT2NE20104000 0 0 0 100
    NT2NE20107810 0 0 0 100
    NT2NE20108420 0 0 0 45.407
    NT2NE20111190 0 0 0 61.289
    NT2NE20112210 0 0 0 26.669
    NT2NE20114850 0 0 0 100
    NT2NE20117580 0 0 0 100
    NT2NE20119980 0 0 0 100
    NT2NE20123610 0 0 0 100
    NT2NE20124570 0 0 0 100
    NT2NE20126030 0 0 0 100
    NT2NE20127900 0 0 16.514 25.025
    NT2NE20140130 0 0 0 100
    NT2NE20140280 0 0 0 100
    NT2NE20141040 0 0 0 36.013
    NT2NE20145250 0 0 0 100
    NT2NE20146510 0 0 0 100
    NT2NE20148690 0 0 0 67.567
    NT2NE20149500 0 0 0 100
    NT2NE20150610 0 0 0 100
    NT2NE20152620 0 0 0 100
    NT2NE20153620 0 0 0 60.858
    NT2NE20155650 0 0 0 100
    NT2NE20157120 0 0 0 100
    NT2NE20165190 0 0 0 100
    NT2NE20167660 0 0 0 100
    NT2NE20173970 0 0 0 100
    NT2NE20177210 0 0 0 43.734
    NT2NE20181760 0 0 0 100
    NT2NE20181800 0 0 0 46.215
    NT2NE20184720 0 0 0 100
    NT2RI20016240 0 0 100 0
    NT2RI20021200 0 0 8.844 0
    NT2RI20033920 0 0 100 0
    NT2RI20093010 0 0 100 0
    NT2RP70001120 0 32.573 0 0
    NT2RP70001730 0 15.462 0 0
    NT2RP70003110 0 24.333 0 0
    NT2RP70012830 0 5.639 0 5.798
    NT2RP70022820 0 66.955 0 0
    NT2RP70027790 0 60.194 0 0
    NT2RP70029780 0 100 0 0
    NT2RP70030840 0 100 0 0
    NT2RP70031070 0 100 0 0
    NT2RP70031340 0 100 0 0
    NT2RP70031480 0 100 0 0
    NT2RP70035110 0 23.442 0 0
    NT2RP70046410 0 64.358 0 0
    NT2RP70049610 0 100 0 0
    NT2RP70056290 0 100 0 0
    NT2RP70056690 0 100 0 0
    NT2RP70057500 0 13.6 0 0
    NT2RP70064570 0 60.194 0 0
    NT2RP70074800 0 100 0 0
    NT2RP70075300 0 6.726 0 0
    NT2RP70075800 0 100 0 0
    NT2RP70080150 0 100 0 0
    NT2RP70084540 0 100 0 0
    NT2RP70087140 0 7.444 15.153 7.654
    NT2RP70090870 0 17.122 11.617 0
    OCBBF20001780 0 0 15.351 0
    OCBBF20009820 84.348 0 0 0
    OCBBF20142290 0 0 0 14.577
    OCBBF20155030 0 49.439 0 0
    OCBBF20175360 0 0 0 20.881
    OCBBF20177540 0 25.509 0 0
    OCBBF20177910 0 0 23.505 0
    PLACE60054820 0 0 20.089 0
    PLACE60061370 0 18.07 0 0
    PLACE60073090 0 10.617 0 0
    PLACE60162100 0 0 0 37.629
    PROST20011800 0 0 0 50.542
    PROST20045700 0 0 0 44.59
    PROST20078710 0 0 0 33.633
    PROST20094000 0 0 18.34 0
    PUAEN10000650 0 3.375 0 0
    PUAEN10001640 0 5.216 3.539 0
    SKNMC20006350 0 2.005 2.041 4.124
    SMINT20016150 0 49.972 0 0
    SMINT20030740 0 5.712 0 0
    SMINT20035510 0 0 28.984 0
    SMINT20039050 0 0 18.576 9.383
    SMINT20047290 0 39.6 0 0
    SPLEN20063250 0 8.081 8.225 8.309
    SPLEN20117580 0 0 0 24.462
    SPLEN20125230 0 0 21.559 0
    TESTI20030610 0 0 0 12.205
    TESTI20043910 0 0 0 45.963
    TESTI20066280 0 0 0 30.676
    TESTI20067480 0 8.861 0 0
    TESTI20105130 0 0 0 2.5
    TESTI20106170 0 13.104 0 0
    TESTI20143180 0 0 62.741 0
    TESTI20221790 0 0 39.167 0
    TESTI20254090 0 0 0 19.063
    TESTI20274960 0 0 38.685 0
    THYMU10004280 0 3.573 0 0
    THYMU20007020 0 0 71.017 0
    THYMU20104480 0 0 29.694 0
    THYMU20139160 0 1.822 0.618 0
    TRACH20026640 0 0 7.476 0
    UTERU10001060 0 0 19.967 0
    UTERU20026620 0 10.41 0 10.703
    UTERU20079240 0 0 0 19.734
    UTERU20083020 0 7.182 0 0
    UTERU20102260 0 0 0 23.706
    UTERU20132620 0 48.06 0 0
  • TABLE 5
    Clone ID BEAST TBAES
    CTONG20070780 0 97.283
    CTONG20084660 0 89.108
    HLUNG20045340 0 85.362
    TESTI20047370 0 71.55
  • TABLE 6
    Clone ID CERVX TCERX
    SMINT20030740 0 65.795
  • TABLE 7
    Clone ID COLON TCOLN
    UTERU2004037 68.149 0
  • TABLE 8
    Clone ID NESOP TESOP
    HLUNG20015180 51.695 0
    NESOP20004520 100 0
    NESOP20005040 100 0
    TESOP10000350 0 86.127
    TESOP10001600 0 100
    THYMU20071120 0 81.712
  • TABLE 9
    Clone ID KIDNE TKIDN
    ASTRO20009140 19.518 0
    ASTRO20027330 0 30.903
    ASTRO20055930 0 36.981
    BGGI120010750 4.532 0
    BNGH420074600 0 11.358
    BRACE20050870 0 15.884
    BRACE20054480 29.719 0
    BRACE20062580 2.613 0
    BRACE20219360 59.494 0
    BRAMY20003540 4.676 0
    BRAMY20003880 16.882 41.527
    BRAMY20043630 3.51 0
    BRAMY20055760 0 65.196
    BRAMY20125360 0 32.672
    BRAMY20190550 0 19.772
    BRAMY20204270 3.618 0
    BRAMY20227860 0 4.255
    BRAWH20014590 0 23.509
    BRAWH20093070 0 14.759
    BRHIP10001040 0 5.496
    CTONG20033750 59.93 0
    CTONG20039370 59.93 0
    CTONG20045500 59.93 0
    CTONG20079590 0 17.392
    FCBBF20023490 14.59 0
    FCBBF30004340 0 10.386
    FCBBF30106950 0 69.888
    FCBBF30115230 0 69.888
    FCBBF30169280 0 38.857
    FCBBF30225930 0 50.898
    FCBBF30282020 0 53.714
    FEBRA20038330 0 6.538
    FEBRA20039260 7.084 0
    FEBRA20040290 7.711 0
    FEBRA20082660 0 77.359
    FEBRA20121200 0 63.078
    FEBRA20170240 0 63.078
    HEART10001490 20.269 0
    HLUNG20041590 4.744 0
    HLUNG20068120 11.84 0
    HLUNG20072450 3.599 0
    HLUNG20083480 0 15.004
    HLUNG20083960 18.946 0
    KIDNE20011600 100 0
    KIDNE20016360 59.589 0
    KIDNE20024380 100 0
    KIDNE20027980 100 0
    KIDNE20080690 5.861 0
    KIDNE20081170 100 0
    KIDNE20083150 100 0
    KIDNE20083620 100 0
    KIDNE20084030 40.03 0
    KIDNE20084040 34.084 0
    KIDNE20084730 100 0
    KIDNE20084800 100 0
    KIDNE20086490 87.61 0
    KIDNE20086660 47.013 0
    KIDNE20086970 100 0
    KIDNE20087880 28.683 0
    KIDNE20088240 100 0
    KIDNE20089870 3.987 0
    KIDNE20091090 100 0
    KIDNE20094260 100 0
    KIDNE20094670 59.494 0
    KIDNE20095530 100 0
    KIDNE20133460 100 0
    KIDNE20133880 100 0
    KIDNE20134130 65.363 0
    KIDNE20134890 100 0
    KIDNE20137310 100 0
    KIDNE20138450 38.971 0
    KIDNE20140870 22.93 0
    KIDNE20141120 100 0
    KIDNE20141700 100 0
    KIDNE20142680 100 0
    KIDNE20142680 100 0
    KIDNE20142900 31.732 0
    KIDNE20143200 100 0
    KIDNE20147170 100 0
    KIDNE20148080 100 0
    KIDNE20149780 60.365 0
    KIDNE20150730 100 0
    KIDNE20152440 100 0
    KIDNE20154330 100 0
    KIDNE20154830 100 0
    KIDNE20155980 100 0
    KIDNE20157100 100 0
    KIDNE20160360 100 0
    KIDNE20160960 100 0
    KIDNE20163710 100 0
    KIDNE20165390 100 0
    KIDNE20169180 100 0
    KIDNE20170400 19.556 0
    KIDNE20173150 100 0
    KIDNE20173430 36.673 0
    KIDNE20176030 100 0
    KIDNE20181670 100 0
    KIDNE20182540 100 0
    KIDNE20186170 100 0
    KIDNE20188630 100 0
    KIDNE20189890 100 0
    KIDNE20189960 100 0
    KIDNE20191870 100 0
    MESAN20038520 0 11.358
    MESAN20041380 0 53.625
    OCBBF20016390 0 23.211
    OCBBF20142290 0 8.623
    OCBBF20174890 32.241 0
    PLACE60061370 0 21.981
    PLACE60073090 10.501 0
    PLACE60181870 49.921 0
    PROST20016760 3.992 9.82
    PUAEN10000650 6.676 0
    SMINT20039050 0 11.102
    SMINT20089210 0 12.885
    SPLEN20017610 42.429 0
    SPLEN20024930 0 22.541
    SPLEN20057830 0 35
    SPLEN20063250 3.996 0
    SPLEN20126110 50.05 0
    SPLEN20135030 31.695 0
    SPLEN20136700 0 39.807
    TESTI20070740 0 75.118
    TESTI20262150 40.96 0
    THYMU20009500 0 24.928
    THYMU20019260 0 36.869
    THYMU20157620 0 19.973
    TKIDN10000620 0 100
    TKIDN10001710 0 100
    TKIDN10001920 0 36.869
    TRACH20011010 10.647 0
    UMVEN10001380 0 4.196
  • TABLE 10
    Clone ID LIVER TLIVE
    CTONG20069320 20.862 0
    FCBBF30236670 3.257 0
    FEBRA20038220 77.547 0
    FEBRA20039260 8.806 0
    KIDNE20087880 71.317 0
    LIVER20006260 100 0
    LIVER20007690 85.922 0
    LIVER20007750 100 0
    LIVER20010510 100 0
    LIVER20010760 100 0
    LIVER20010990 100 0
    LIVER20011640 100 0
    LIVER20013890 100 0
    LIVER20026440 100 0
    LIVER20030650 100 0
    LIVER20032340 100 0
    LIVER20038000 100 0
    LIVER20040740 100 0
    LIVER20055270 100 0
    MESAN20027240 21.684 0
    NT2RI20021200 16.028 0
    SKMUS20006790 6.063 0
    TESTI20035330 22.045 0
    THYMU10004280 8.787 4.346
    THYMU20029830 31.692 0
  • TABLE 11
    Clone ID HLUNG TLUNG
    HLUNG20052300 23.611 0
    SMINT20035050 6.135 0
    HLUNG20041590 10.207 0
    PROST20016760 8.589 0
    BRAMY20043630 15.102 0
    HLUNG20015180 4.723 0
    THYMU20139160 1.939 0
    HLUNG20020850 67.488 0
    HLUNG20032460 44.037 0
    BRAMY20204270 7.785 0
    BRAMY20001510 5.948 0
    BRAMY20227860 1.488 0
    CTONG20029030 28.504 0
    CTONG20168460 76.291 0
    CTONG20186290 61.67 0
    FEBRA20039260 7.62 0
    FEBRA20078800 33.686 0
    FEBRA20163980 38.327 0
    HCHON20000870 23.288 0
    HLUNG20008460 67.54 0
    HLUNG20009260 100 0
    HLUNG20009550 100 0
    HLUNG20010130 100 0
    HLUNG20011260 100 0
    HLUNG20011440 100 0
    HLUNG20011460 76.577 0
    HLUNG20012140 100 0
    HLUNG20014590 36.045 0
    HLUNG20015070 17.804 0
    HLUNG20020500 100 0
    HLUNG20021450 68.006 0
    HLUNG20023030 100 0
    HLUNG20024050 100 0
    HLUNG20025620 100 0
    HLUNG20028110 76.618 0
    HLUNG20029420 100 0
    HLUNG20029490 81.173 0
    HLUNG20030420 100 0
    HLUNG20030490 100 0
    HLUNG20030610 100 0
    HLUNG20031620 80.237 0
    HLUNG20033060 36.529 0
    HLUNG20033310 100 0
    HLUNG20033350 100 0
    HLUNG20034970 79.349 0
    HLUNG20037140 100 0
    HLUNG20037160 100 0
    HLUNG20037780 44.761 0
    HLUNG20038330 100 0
    HLUNG20041540 100 0
    HLUNG20042730 100 0
    HLUNG20045340 7.67 0
    HLUNG20047070 100 0
    HLUNG20050760 100 0
    HLUNG20051330 100 0
    HLUNG20054790 100 0
    HLUNG20055240 100 0
    HLUNG20056560 75.961 0
    HLUNG20057380 100 0
    HLUNG20059240 100 0
    HLUNG20060670 100 0
    HLUNG20063700 100 0
    HLUNG20065700 62.8 0
    HLUNG20065990 100 0
    HLUNG20067810 100 0
    HLUNG20068120 50.947 0
    HLUNG20069350 100 0
    HLUNG20070410 100 0
    HLUNG20072100 54.241 0
    HLUNG20072190 79.349 0
    HLUNG20072450 7.744 0
    HLUNG20074330 100 0
    HLUNG20079310 100 0
    HLUNG20081390 66.429 0
    HLUNG20081530 100 0
    HLUNG20082350 100 0
    HLUNG20083330 100 0
    HLUNG20083480 13.123 0
    HLUNG20083840 100 0
    HLUNG20083960 40.76 0
    HLUNG20084790 100 0
    HLUNG20085210 50.993 0
    HLUNG20088750 100 0
    HLUNG20092530 100 0
    HLUNG20093030 100 0
    HLUNG20094130 75.987 0
    KIDNE20142900 68.268 0
    PROST20052850 57.701 0
    SKNMC20006350 2.134 0
    SPLEN20012450 25.695 0
    TESTI20057590 17.804 0
    TESTI20061200 29.123 0
    TESTI20067480 18.856 0
    TESTI20116050 30.168 0
    THYMU10004280 7.603 0
    THYMU20010180 79.349 0
    TRACH20011010 22.907 0
    UTERU20016580 43.64 0
    UTERU20127030 66.318 0
  • TABLE 12
    Clone ID NOVAR TOVAR
    KIDNE20089870 91.868 0
    NT2RP70075300 76.633 0
    TESTI20132310 94.177 0
  • TABLE 13
    Clone ID STOMA TSTOM
    BNGH420087430 0 91.629
    BRAMY20227860 1.35 0
    BRAWH20027250 42.096 0
    CTONG20174440 26.346 0
    FEBRA20090220 4.442 0
    PUAEN10000650 13.031 0
    SMINT20023110 72.094 0
    SMINT20030740 5.514 0
    SMINT20045890 34.092 0
    SPLEN20048800 2.011 0
    SPLEN20139360 79.641 0
    TESTI20063410 28.273 0
    TESTI20150920 33.158 0
    TRACH20026640 21.272 0
    UTERU20041970 0 72.886
  • TABLE 14
    Clone ID UTERU TUTER
    ADRGL20020290 21.538 0
    BRACE20038920 10.185 0
    BRAMY20091230 39.224 0
    BRAMY20093490 62.465 0
    BRAMY20227860 2.268 0
    BRHIP20005060 61.644 0
    CTONG20069320 18.336 0
    CTONG20083430 62.039 0
    FCBBF30005360 41.409 0
    FCBBF30257370 21.099 0
    FEBRA20038330 5.808 0
    FEBRA20039260 7.74 0
    FEBRA20040260 43.146 0
    FEBRA20078180 31.447 0
    FEBRA20087550 10.505 0
    HLUNG20015070 9.042 0
    HLUNG20015180 7.196 0
    MESAN20007110 50.674 0
    MESAN20067430 20.114 0
    MESAN20095800 14.162 0
    NT2RP70057500 14.698 0
    SKMUS20008730 2.775 0
    SKNMC20006350 1.084 0
    SMINT20035050 3.116 0
    SMINT20045890 19.084 0
    SPLEN20073880 30.142 0
    SPLEN20076470 17.567 0
    SPLEN20118050 33.583 0
    TESTI20030610 12.829 0
    TESTI20035330 9.688 0
    TESTI20057590 9.042 0
    TESTI20059080 9.096 0
    TESTI20105130 0 57.51
    THYMU10004280 3.861 0
    THYMU20139160 1.969 21.546
    UTERU10001060 31.804 0
    UTERU10001870 100 0
    UTERU20000230 34.999 0
    UTERU20000950 3.88 0
    UTERU20011760 100 0
    UTERU20013890 100 0
    UTERU20016580 22.164 0
    UTERU20026620 33.752 0
    UTERU20027360 100 0
    UTERU20029930 72.842 0
    UTERU20031350 100 0
    UTERU20035770 100 0
    UTERU20040150 100 0
    UTERU20040370 6.264 0
    UTERU20040390 100 0
    UTERU20040730 100 0
    UTERU20041630 100 0
    UTERU20041970 6.578 0
    UTERU20045200 62.039 0
    UTERU20051790 100 0
    UTERU20064120 100 0
    UTERU20065470 50.58 0
    UTERU20079240 20.742 0
    UTERU20083020 7.762 0
    UTERU20086530 100 0
    UTERU20087070 100 0
    UTERU20087850 100 0
    UTERU20089300 27.655 0
    UTERU20089390 17.567 0
    UTERU20089620 100 0
    UTERU20090940 100 0
    UTERU20091470 100 0
    UTERU20094830 100 0
    UTERU20095100 39.739 0
    UTERU20099040 100 0
    UTERU20099510 100 0
    UTERU20101150 100 0
    UTERU20102260 24.918 0
    UTERU20103040 100 0
    UTERU20103200 51.815 0
    UTERU20104310 100 0
    UTERU20106510 100 0
    UTERU20121140 100 0
    UTERU20122520 51.33 0
    UTERU20125810 100 0
    UTERU20127030 33.682 0
    UTERU20127150 62.412 0
    UTERU20128560 36.129 0
    UTERU20132620 51.94 0
    UTERU20134830 100 0
    UTERU20139760 100 0
    UTERU20140010 100 0
    UTERU20167570 100 0
    UTERU20168960 100 0
    UTERU20169020 100 0
    UTERU20173030 100 0
    UTERU20176230 72.842 0
    UTERU20177150 100 0
    UTERU20181270 100 0
    UTERU20185220 100 0
    UTERU20188670 100 0
    UTERU20188840 40.303 0
  • TABLE 15
    Clone ID NTONG CTONG
    ADRGL20023920 13.989 0
    BRACE20038920 0 24.929
    BRACE20050870 0 34.54
    BRACE20061620 63.015 0
    BRAMY20036530 21.217 0
    BRAMY20076130 0 6.434
    BRAMY20204270 0 2.419
    BRAMY20267780 0 4.633
    BRCAN10001680 14.71 0
    CTONG10000090 0 87.752
    CTONG20000340 0 100
    CTONG20002790 0 100
    CTONG20004110 0 100
    CTONG20004520 0 100
    CTONG20007660 0 100
    CTONG20008190 0 100
    CTONG20008460 0 100
    CTONG20015240 0 100
    CTONG20017490 0 100
    CTONG20020660 0 100
    CTONG20020950 0 100
    CTONG20027660 0 49.358
    CTONG20029030 0 44.292
    CTONG20030280 0 100
    CTONG20031150 0 100
    CTONG20031890 0 62.139
    CTONG20032930 0 29.763
    CTONG20033500 0 100
    CTONG20033610 0 57.263
    CTONG20033750 0 40.07
    CTONG20035240 0 55.786
    CTONG20036800 0 100
    CTONG20036990 0 100
    CTONG20039370 0 40.07
    CTONG20041150 0 100
    CTONG20041260 0 100
    CTONG20042640 0 100
    CTONG20044230 0 49.358
    CTONG20044870 0 74.685
    CTONG20045500 0 40.07
    CTONG20046690 0 100
    CTONG20049480 0 100
    CTONG20050490 0 100
    CTONG20051100 0 100
    CTONG20051450 0 100
    CTONG20052780 0 100
    CTONG20053990 0 100
    CTONG20055670 0 100
    CTONG20055850 0 24.814
    CTONG20056150 0 51.203
    CTONG20057750 0 100
    CTONG20057950 0 54.423
    CTONG20059130 0 72.445
    CTONG20060040 0 72.825
    CTONG20061290 0 100
    CTONG20062730 0 100
    CTONG20063770 0 62.139
    CTONG20063930 0 28.37
    CTONG20065240 0 100
    CTONG20065680 0 100
    CTONG20066110 0 37.292
    CTONG20068360 0 100
    CTONG20069320 0 11.22
    CTONG20069420 0 42.813
    CTONG20070090 0 100
    CTONG20070720 0 7.689
    CTONG20070780 0 2.717
    CTONG20070910 0 100
    CTONG20071040 0 32.374
    CTONG20071680 0 49.582
    CTONG20072930 0 100
    CTONG20073990 0 100
    CTONG20074000 0 100
    CTONG20074170 0 55.786
    CTONG20074740 0 100
    CTONG20076230 0 100
    CTONG20076810 0 100
    CTONG20077760 0 100
    CTONG20078340 0 74.685
    CTONG20079590 0 9.455
    CTONG20080140 0 27.673
    CTONG20081840 0 100
    CTONG20083430 0 37.961
    CTONG20083980 0 100
    CTONG20084020 0 100
    CTONG20084660 0 2.488
    CTONG20085210 0 27.762
    CTONG20133720 18.528 46.879
    CTONG20165590 0 100
    CTONG20165750 0 11.978
    CTONG20166580 0 100
    CTONG20167750 0 100
    CTONG20168240 37.367 11.818
    CTONG20168460 0 23.709
    CTONG20169040 0 100
    CTONG20169530 0 100
    CTONG20170940 0 89.253
    CTONG20174290 0 100
    CTONG20174580 0 100
    CTONG20176040 0 100
    CTONG20179390 0 100
    CTONG20179890 0 100
    CTONG20179980 0 100
    CTONG20180620 0 100
    CTONG20180690 0 100
    CTONG20181350 0 100
    CTONG20183430 0 55.786
    CTONG20183830 0 22.718
    CTONG20184130 0 100
    CTONG20184830 0 100
    CTONG20186140 0 100
    CTONG20186290 0 38.33
    CTONG20186370 0 39.387
    CTONG20186520 0 100
    CTONG20186550 0 100
    CTONG20188080 43.151 6.824
    CTONG20189000 0 100
    CTONG20190290 0 100
    CTONG20190630 0 100
    FCBBF20070950 0 14.977
    FCBBF30001100 0 24.477
    FCBBF30175350 32.34 10.228
    FCBBF40005000 0 20.766
    FEBRA20027070 26.269 0
    FEBRA20038330 0 3.554
    FEBRA20039260 7.487 0
    FEBRA20040290 0 2.578
    FEBRA20046200 0 16.309
    FEBRA20063720 0 8.106
    FEBRA20078800 0 10.469
    FEBRA20090220 0 12.173
    HCHON20000870 0 7.237
    HLUNG20068120 25.03 0
    MESAN20008150 0 38.598
    MESAN20027900 0 17.599
    NT2NE20153620 0 39.142
    NT2RP70001730 0 4.09
    NT2RP70012830 0 3.729
    NT2RP70027790 0 39.806
    NT2RP70057500 0 8.993
    NT2RP70064570 0 39.806
    NT2RP70090870 35.801 0
    NTONG20002230 50.815 0
    NTONG20005310 100 0
    NTONG20017620 29.697 0
    NTONG20029850 100 0
    NTONG20031580 100 0
    NTONG20032100 100 0
    NTONG20034540 67.622 0
    NTONG20035150 80.903 0
    NTONG20043080 100 0
    NTONG20048440 100 0
    NTONG20049180 63.818 20.184
    NTONG20053630 100 0
    NTONG20053730 100 0
    NTONG20053910 100 0
    NTONG20055200 10.784 3.411
    NTONG20058010 100 0
    NTONG20058220 100 0
    OCBBF20110730 0 11.1
    OCBBF20177540 0 16.869
    OCBBF20177910 0 22.909
    PROST20016760 0 2.669
    PROST20042700 0 33.088
    PROST20050390 0 30.175
    PROST20063430 50.958 0
    PROST20130320 0 11.979
    PUAEN10000650 7.056 0
    PUAEN10001640 0 13.798
    PUAEN20003120 0 19.799
    SKMUS20006790 5.155 0
    SKNMC20006350 0 3.316
    SKNSH20007160 0 9.506
    SMINT20030740 0 5.666
    SMINT20035510 0 28.25
    SMINT20089210 0 7.005
    SPLEN20024930 0 12.254
    SPLEN20040780 0 20.5
    SPLEN20063250 0 8.016
    SPLEN20181570 0 4.523
    SPLEN20187490 0 23.141
    TESTI20047370 0 1.998
    TESTI20057880 0 15.357
    TESTI20064530 0 10.734
    TESTI20079980 0 8.166
    TESTI20105130 0 4.825
    TESTI20118460 63.366 0
    TESTI20121040 0 17.698
    TESTI20197290 0 62.139
    THYMU10004280 0 2.363
    THYMU20030460 14.321 4.53
    THYMU20055460 0 10.818
    THYMU20089900 0 37.939
    THYMU20121040 0 54.423
    THYMU20139160 1.905 4.82
    THYMU20145990 0 37.385
    TRACH20011010 0 28.476
    TRACH20090060 0 6.234
    UTERU20000230 0 21.416
    UTERU20000950 0 2.374
    UTERU20016580 0 13.562
    UTERU20045200 0 37.961
    UTERU20083020 15.017 0
  • TABLE 16
    Clone ID FCBBF FEBRA OCBBF BRACE BRALZ BRAMY BRAWH BRCAN BRCOC BRHIP BRSSN BRSTN BRTHA
    ADRGL- 0 0 0 0 0 12.942 0 0 0 0 0 0 0
    20020290
    ADRGL- 0 0 0 0 0 21.897 0 0 0 22.674 0 0 0
    20021910
    ADRGL- 0 0 0 4.505 0 0 0 0 0 0 0 0 0
    20023920
    ADRGL- 8.812 35.914 0 0 0 0 0 0 0 0 0 0 0
    20046760
    ADRGL- 0 0 0 0 0 0 0 28.364 0 0 0 0 0
    20062330
    ADRGL-0 0 0 0 0 0 0 28.364 0 0 0 0 0
    20079060
    ASTRO- 0 0 0 0 0 0 21.998 0 0 0 0 0 0
    20009140
    ASTRO- 0 0 0 0 0 38.79 0 0 0 0 0 0 0
    20020240
    ASTRO- 0 0 25.981 0 0 0 0 0 0 17.083 0 0 0
    20027330
    ASTRO- 0 0 0 0 0 0 0 0 0 0 0 49.891 0
    20047510
    ASTRO- 0 10.089 28.982 0 0 9.201 0 0 0 0 0 0 0
    20055530
    ASTRO- 0 0 0 0 0 0 0 38.844 0 0 0 0 0
    20055570
    ASTRO- 31.867 0 0 0 0 0 0 0 0 0 0 0 0
    20055930
    ASTRO- 0 0 0 0 0 0 0 0 0 0 33.707 0 0
    20090680
    BGGI- 4.804 0 0 0 0 0 0 0 0 0 0 0 0
    120010750
    BNGH- 0 0 0 10.084 0 0 0 0 0 0 0 0 0
    420021680
    BNGH- 0 0 0 0 0 0 0 0 0 0 0 0 52.181
    420023870
    BNGH- 8.889 0 0 0 0 0 0 0 0 0 0 0 0
    420059680
    BNGH- 4.894 0 0 0 0 12.127 0 0 0 0 0 0 0
    420074600
    BNGH- 0 0 0 0 0 8.414 0 8.433 0 0 0 0 0
    420086030
    BRACE- 0 0 0 55.676 0 0 30.722 0 0 0 0 0 0
    10000510
    BRACE- 0 0 0 29.513 0 0 48.856 0 0 0 0 0 0
    20003310
    BRACE- 0 0 0 38.94 0 0 0 0 0 0 61.06 0 0
    20007330
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20009050
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20014450
    BRACE- 43.768 0 0 56.232 0 0 0 0 0 0 0 0 0
    20017790
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20018810
    BRACE- 0 0 0 50.035 0 0 0 0 0 49.965 0 0 0
    20025820
    BRACE- 0 20.132 9.638 6.346 0 12.24 0 0 0 0 0 0 0
    20038920
    BRACE- 6.844 0 26.708 8.793 0 0 0 0 0 0 0 0 0
    20050870
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20051600
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20051930
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20052430
    BRACE- 0 0 0 19.237 0 0 0 0 0 0 0 0 80.763
    20052530
    BRACE- 0 0 0 26.402 0 0 0 25.519 0 26.365 0 0 0
    20054080
    BRACE- 0 0 0 40.468 0 0 0 0 0 0 0 0 0
    20054480
  • TABLE 17
    BRACE20054600 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20055560 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20057870 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20059110 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20059810 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20061620 0 0 0 20.295 0 0 0 0 0 0 0 0 0
    BRACE20062580 1.385 13.17 0 3.558 2.709 0 2.945 1.72 2.655 0 5.58 0 0
    BRACE20063540 0 23.259 0 21.996 33.485 0 0 21.26 0 0 0 0 0
    BRACE20065470 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20066360 0 0 60.297 39.703 0 0 0 0 0 0 0 0 0
    BRACE20068710 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20069000 0 0 0 11.616 0 0 0 0 0 0 0 0 0
    BRACE20069110 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20069440 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20079200 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20079370 28.774 29.318 0 18.484 0 0 0 0 0 0 0 0 0
    BRACE20097540 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20098860 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20099070 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20194670 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20196180 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20196960 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20200770 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20200970 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20204670 0 0 0 6.427 0 0 0 0 0 0 0 0 0
    BRACE20205840 0 0 0 100 0 0 0 0 0 0 0 0 0
    BRACE20207420 0 0 0 100 0 0 0 0 0 0 0 0 0
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  • TABLE 18
    BRAMY20003540 4.956 0 0 3.184 0 3.07 10.541 6.155 0 9.538 0 4.824 0
    BRAMY20003880 0 0 0 0 0 11.085 19.028 0 0 11.478 0 0 0
    BRAMY20005080 0 0 0 0 0 19.453 33.393 0 0 0 0 30.564 0
    BRAMY20013670 0 0 0 0 0 100 0 0 0 0 0 0 0
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    BRAMY20020440 0 0 0 0 0 100 0 0 0 0 0 0 0
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    BRAMY20023640 0 0 0 0 0 100 0 0 0 0 0 0 0
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    BRAMY20027390 0 0 0 0 0 100 0 0 0 0 0 0 0
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    BRAMY20036530 0 0 0 0 0 13.18 0 0 0 0 0 0 0
    BRAMY20036810 0 0 0 0 0 61.711 0 0 0 0 0 0 0
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    BRAMY20072440 0 17.768 0 16.803 0 32.409 0 16.241 0 16.78 0 0 0
  • TABLE 19
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    BRAMY20073080 0 0 0 0 0 100 0 0 0 0 0 0 0
    BRAMY20074110 0 0 0 0 0 100 0 0 0 0 0 0 0
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    BRAMY20093490 0 0 0 0 0 37.535 0 0 0 0 0 0 0
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    BRAMY20095570 0 0 0 0 0 49.128 0 0 0 50.872 0 0 0
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    BRAMY20118410 0 0 0 0 0 49.128 0 0 0 50.872 0 0 0
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    BRAMY20152510 17.703 0 0 0 0 21.934 37.651 0 0 22.713 0 0 0
    BRAMY20155500 0 0 0 0 0 53.973 0 0 0 0 0 0 0
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    BRAMY20194680 0 0 0 0 0 100 0 0 0 0 0 0 0
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  • TABLE 21
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    BRAWH20020470 0 0 0 37.659 0 0 62.341 0 0 0 0 0 0
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    BRAWH20025490 0 0 0 0 0 0 52.588 0 47.412 0 0 0 0
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    BRAWH20027250 0 0 0 0 0 0 24.306 0 0 0 0 0 0
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  • TABLE 22
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  • TABLE 23
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    CTONG20085210 44.007 0 0 0 0 0 0 0 0 28.231 0 0 0
    CTONG20133720 0 0 0 0 0 5.755 0 0 0 5.959 0 0 0
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  • TABLE 24
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  • TABLE 25
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    FCBBF30223110 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30223210 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30225930 21.93 0 0 0 0 27.172 0 0 0 0 0 0 0
    FCBBF30228940 51.503 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30230610 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30236670 0.694 2.83 0 0.892 1.358 0 0 2.586 0 0.891 2.797 0 3.745
    FCBBF30250980 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30255680 100 0 0 0 0 0 0 0 0 0 0 0 0
  • TABLE 27
    FCBBF30257370 15.348 13.901 0 0 0 0 0 0 0 0 0 9.959 0
    FCBBF30259050 43.768 0 0 56.232 0 0 0 0 0 0 0 0 0
    FCBBF30260210 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30260480 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30263080 23.584 0 0 0 0 0 0 29.288 0 0 0 0 0
    FCBBF30266510 56.537 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30271990 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30275590 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30282020 46.286 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30285930 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF30287940 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF40000610 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF40001920 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF40005000 16.459 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF50000410 100 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF50000610 43.582 0 0 0 0 0 0 0 0 0 0 0 0
    FCBBF50001650 33.921 15.361 0 14.527 0 14.01 0 0 0 0 0 0 0
    FCBBF50003530 44.606 0 0 0 0 0 0 55.394 0 0 0 0 0
    FCBBF50004950 100 0 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20005040 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20007820 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20018670 27.69 18.809 0 0 0 0 0 0 26.549 0 0 26.952 0
    FEBRA20026820 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20027070 0 8.946 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20029620 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20031000 23.203 31.522 45.275 0 0 0 0 0 0 0 0 0 0
    FEBRA20031150 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20031280 0 58.203 41.797 0 0 0 0 0 0 0 0 0 0
    FEBRA20031810 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20035200 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20035240 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20038220 0 22.453 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20038330 5.634 15.308 5.497 0 0 6.981 0 0 5.402 0 0 0 15.195
    FEBRA20038970 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20039070 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20039260 0 2.55 0 2.411 0 2.325 0 0 3.599 2.408 0 3.654 0
    FEBRA20040230 0 63.862 0 0 0 0 0 0 0 0 0 0 0
  • TABLE 28
    FEBRA20040260 0 56.854 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20040290 2.043 2.776 0 0 7.992 2.531 0 5.074 0 0 0 0 11.021
    FEBRA20040560 0 59.062 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20045380 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20046200 0 17.561 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20046280 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20046510 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20057010 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20063720 0 34.914 12.537 0 0 0 0 0 0 0 0 0 0
    FEBRA20076200 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20078180 0 20.719 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20078800 0 22.544 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20080860 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20082660 0 22.641 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20083410 0 14.361 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20084750 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20086600 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20087550 0 6.921 0 0 0 0 0 0 9.769 0 0 0 0
    FEBRA20088610 24.122 32.771 15.689 0 0 0 17.101 0 0 10.316 0 0 0
    FEBRA20088810 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20090160 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20090220 0 6.554 2.353 0 2.359 0 2.565 0 6.938 0 2.43 0 0
    FEBRA20091620 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20092760 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20093270 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20093280 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20095410 0 59.062 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20098040 13.01 35.349 0 0 0 0 0 0 24.947 16.692 0 0 0
    FEBRA20099860 0 34.616 0 0 0 0 0 0 0 65.384 0 0 0
    FEBRA20101410 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20108020 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20108580 8.812 35.914 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20115930 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20116650 18.022 24.484 35.165 0 0 22.329 0 0 0 0 0 0 0
    FEBRA20121200 0 36.922 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20121950 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20141980 0 100 0 0 0 0 0 0 0 0 0 0 0
  • TABLE 29
    FEBRA20150420 0 34.905 0 0 0 31.834 0 0 0 0 0 0 0
    FEBRA20151750 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20163980 9.44 12.825 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20170240 0 36.922 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20172230 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20173330 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20175020 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20175330 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20177800 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20180510 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20182030 42.399 57.601 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20187460 0 100 0 0 0 0 0 0 0 0 0 0 0
    FEBRA20191720 0 100 0 0 0 0 0 0 0 0 0 0 0
    HCHON20002650 0 0 0 19.66 0 0 0 0 0 0 0 0 0
    HCHON20002710 13.027 17.697 0 0 0 0 0 0 0 0 0 0 0
    HEART10001490 3.58 0 6.986 0 0 0 0 0 0 0 0 0 0
    HLUNG20008460 0 0 32.46 0 0 0 0 0 0 0 0 0 0
    HLUNG20011460 0 0 0 0 0 0 0 23.423 0 0 0 0 0
    HLUNG20014590 0 0 0 0 0 0 0 11.025 0 0 0 0 0
    HLUNG20015070 0 0 0 0 0 5.433 0 0 8.409 0 0 0 0
    HLUNG20015180 0 3.161 0 0 0 0 0 0 0 0 4.688 0 0
    HLUNG20020850 0 0 0 0 32.512 0 0 0 0 0 0 0 0
    HLUNG20028110 0 0 0 0 0 23.382 0 0 0 0 0 0 0
    HLUNG20031620 19.763 0 0 0 0 0 0 0 0 0 0 0 0
    HLUNG20032460 0 0 0 0 21.215 0 0 13.47 0 0 0 0 0
    HLUNG20033060 0 0 17.556 0 0 0 0 0 0 11.544 0 0 0
    HLUNG20041590 2.514 3.415 0 0 0 3.115 0 3.122 0 0 0 0 0
    HLUNG20045340 0 0 0 0 0 0 0 0 0 2.424 0 0 0
    HLUNG20056560 0 0 0 24.039 0 0 0 0 0 0 0 0 0
    HLUNG20068120 6.274 0 0 0 0 0 0 0 0 0 0 0 0
    HLUNG20081390 0 0 0 0 0 0 0 0 0 20.993 0 0 0
    HLUNG20083480 3.232 0 12.614 4.153 0 4.005 0 0 6.198 4.147 0 0 0
    HLUNG20085210 0 0 0 0 0 0 0 0 0 0 0 24.45 0
    HLUNG20094130 0 0 0 0 0 0 0 0 0 24.013 0 0 0
    KIDNE20080690 0 0 0 7.981 24.298 11.545 0 3.857 17.867 3.985 12.514 12.092 0
    KIDNE20084030 0 0 0 0 0 26.283 0 0 0 13.608 0 0 0
    KIDNE20086660 0 0 0 0 0 0 52.987 0 0 0 0 0 0
  • TABLE 30
    KIDNE20094670 0 0 0 40.506 0 0 0 0 0 0 0 0 0
    KIDNE20134130 34.637 0 0 0 0 0 0 0 0 0 0 0 0
    KIDNE20138450 20.652 0 0 0 0 0 0 0 0 0 0 0 0
    KIDNE20140870 12.151 0 0 0 0 0 0 0 23.3 0 0 0 0
    KIDNE20149780 0 0 0 0 0 39.635 0 0 0 0 0 0 0
    KIDNE20170400 0 0 0 0 0 0 0 0 0 13.296 0 0 0
    KIDNE20173430 0 0 0 0 0 0 0 0 0 0 0 0 26.207
    MESAN20021860 0 5.216 0 0 0 0 0 0 0 0 0 7.474 0
    MESAN20030350 19.943 0 0 0 0 0 0 0 0 0 0 0 0
    MESAN20034440 0 0 0 0 0 0 0 0 0 0 0 19.81 0
    MESAN20038520 4.894 0 0 0 0 12.127 0 0 0 0 0 0 0
    MESAN20045750 0 0 0 0 0 0 0 0 48.859 0 0 0 0
    MESAN20067430 0 0 0 0 0 0 0 0 0 0 0 0 26.308
    MESAN20089260 24.608 0 0 0 0 0 0 0 0 0 0 0 0
    MESAN20095800 0 0 0 0 0 0 0 8.529 0 8.812 13.837 0 0
    NT2NE20026200 0 0 0 0 1.22 11.547 1.328 0.775 1.197 0 0 3.646 0
    NT2NE20033150 0 0 49.867 0 0 0 0 0 0 0 0 0 0
    NT2NE20042550 0 40.917 0 0 0 0 0 0 0 0 0 0 0
    NT2NE20045190 7.802 0 7.612 0 0 4.834 0 0 0 0 7.86 0 21.043
    NT2NE20053950 21.964 0 21.429 14.11 0 0 0 0 0 0 0 0 0
    NT2NE20061030 20.536 0 0 0 0 0 0 0 0 0 0 0 0
    NT2NE20069580 0 40.917 0 0 0 0 0 0 0 0 0 0 0
    NT2NE20082130 0 0 0 0 0 0 0 24.112 0 0 0 37.798 0
    NT2NE20082600 33.765 0 0 0 0 0 0 0 0 0 0 0 0
    NT2NE20088030 0 0 0 39.575 0 0 0 0 0 0 0 0 0
    NT2NE20092950 0 14.453 0 0 0 0 0 0 0 13.65 0 20.71 0
    NT2NE20095230 0 0 0 0 0 17.429 0 0 0 0 0 27.383 0
    NT2NE20108420 23.147 31.446 0 0 0 0 0 0 0 0 0 0 0
    NT2NE20111190 0 0 0 0 0 38.711 0 0 0 0 0 0 0
    NT2NE20112210 0 0 0 0 0 0 0 0 0 0 0 0 73.331
    NT2NE20141040 0 24.941 0 0 0 0 39.046 0 0 0 0 0 0
    NT2NE20177210 0 0 0 28.643 0 27.623 0 0 0 0 0 0 0
    NT2NE20181800 23.559 0 0 0 0 0 0 0 0 30.226 0 0 0
    NT2RI20021200 0 0 0 0 0 4.233 7.265 8.484 6.55 35.063 6.882 6.65 0
    NT2RP70001120 0 0 33.312 0 0 0 0 0 0 0 0 0 0
    NT2RP70001730 22.691 8.808 31.625 0 0 0 0 0 3.108 0 3.265 0 0
    NT2RP70012830 0 0 11.535 0 0 0 0 0 5.668 0 0 11.508 0
  • TABLE 31
    NT2RP70035110 12.287 0 0 0 0 0 0 0 0 0 0 0 0
    NT2RP70057500 7.128 0 13.909 0 0 0 0 0 0 0 0 0 0
    NT2RP70075300 3.525 0 3.439 2.264 0 2.184 0 0 0 0 0 0 0
    NT2RP70087140 3.902 10.602 0 10.026 0 24.172 0 0 0 0 0 0 21.047
    NT2RP70090870 17.949 0 17.511 0 0 0 0 0 0 0 0 0 0
    NTONG20002230 0 0 24.855 0 0 0 0 0 0 0 0 0 0
    NTONG20017620 22.333 0 14.526 0 0 18.447 0 0 0 0 14.998 0 0
    NTONG20049180 15.998 0 0 0 0 0 0 0 0 0 0 0 0
    NTONG20055200 0 0 0 0 0 0 0 3.357 10.367 10.405 0 0 14.581
    OCBBF20000740 30.257 10.276 44.279 0 0 9.372 0 0 0 0 0 0 0
    OCBBF20001780 0 0 23.138 15.235 23.193 0 0 0 0 0 0 23.084 0
    OCBBF20005220 0 0 67.45 0 0 0 0 0 0 0 0 0 0
    OCBBF20009820 0 0 10.495 0 0 0 0 0 5.157 0 0 0 0
    OCBBF20011860 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20012520 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20016390 10.001 13.586 19.514 0 0 0 21.27 12.419 0 0 0 0 0
    OCBBF20016810 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20109450 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20109780 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20110210 23.865 0 46.566 0 0 29.569 0 0 0 0 0 0 0
    OCBBF20110730 0 35.856 34.333 0 0 0 18.711 0 0 0 0 0 0
    OCBBF20111370 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20111600 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20112280 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20112320 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20113110 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20115360 7.945 10.793 31.004 10.207 0 9.843 0 9.866 0 0 0 0 0
    OCBBF20116250 0 41.046 58.954 0 0 0 0 0 0 0 0 0 0
    OCBBF20117220 15.972 21.698 62.33 0 0 0 0 0 0 0 0 0 0
    OCBBF20118720 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20119810 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20120010 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20120950 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20121910 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20123200 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20142290 0 5.048 21.749 0 0 4.603 0 0 0 14.301 0 0 20.041
    OCBBF20147070 0 0 100 0 0 0 0 0 0 0 0 0 0
  • TABLE 32
    OCBBF20152330 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20155030 0 0 50.561 0 0 0 0 0 0 0 0 0 0
    OCBBF20156450 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20157970 0 0 71.737 0 0 0 0 0 0 0 0 0 0
    OCBBF20160380 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20165900 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20165910 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20166890 0 0 33.861 0 0 0 0 0 0 0 0 0 0
    OCBBF20166900 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20167290 0 0 19.457 0 0 37.065 0 0 0 0 0 0 0
    OCBBF20170350 7.839 10.65 30.593 0 15.332 0 0 9.735 0 10.058 15.793 0 0
    OCBBF20174580 25.726 0 25.099 0 0 0 0 0 0 0 0 0 0
    OCBBF20174890 0 0 33.338 0 0 0 0 0 0 0 34.421 0 0
    OCBBF20175360 10.644 0 20.77 0 0 0 0 0 0 0 0 0 0
    OCBBF20176650 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20177540 13.37 18.164 26.088 0 0 0 0 0 0 0 0 0 0
    OCBBF20177910 18.157 0 35.429 0 0 0 0 0 0 0 0 0 0
    OCBBF20182060 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20185630 0 0 71.737 0 0 0 0 0 0 0 0 0 0
    OCBBF20188280 0 0 100 0 0 0 0 0 0 0 0 0 0
    OCBBF20191950 0 0 100 0 0 0 0 0 0 0 0 0 0
    PLACE60054820 0 0 0 0 0 0 0 19.271 0 0 31.264 0 0
    PLACE60056910 0 0 0 0 0 39.559 0 0 0 0 0 0 0
    PLACE60061370 0 0 0 0 18.524 11.735 0 11.761 0 0 0 0 0
    PLACE60064740 0 0 0 0 0 39.559 0 0 0 0 0 0 0
    PLACE60073090 0 0 0 7.15 0 0 0 0 0 0 0 0 0
    PLACE60120280 0 0 0 0 0 15.655 0 0 0 0 0 0 0
    PLACE60132200 0 0 0 0 0 0 0 0 22.765 0 0 0 0
    PLACE60150510 33.854 0 0 0 0 0 0 0 0 0 34.102 0 0
    PLACE60154450 0 0 0 0 33.747 0 0 0 0 0 0 33.589 0
    PLACE60157310 0 0 0 0 0 0 0 0 66.952 0 0 0 0
    PLACE60162100 0 26.059 0 0 0 0 0 0 0 0 0 0 0
    PROST10002150 10.939 0 0 14.054 0 0 0 0 0 0 0 0 0
    PROST20014150 0 0 67.029 0 0 0 0 0 0 0 0 0 0
    PROST20016760 2.116 2.874 0 5.436 0 5.243 4.5 0 0 2.714 0 4.118 0
    PROST20024250 0 0 32.244 0 0 20.475 0 0 0 0 0 0 0
    PROST20035170 0 0 11.544 0 0 0 0 0 0 0 0 0 0
  • TABLE 33
    PROST20035830 34.251 0 0 0 0 0 0 0 0 0 0 0 0
    PROST20042700 13.112 0 0 0 0 0 0 16.283 0 0 0 0 0
    PROST20045700 11.365 0 0 0 22.229 0 0 0 0 0 0 0 0
    PROST20050390 23.916 0 0 0 0 0 0 0 0 0 0 0 0
    PROST20054660 0 0 0 40.095 0 0 0 0 0 0 0 0 0
    PROST20078710 0 0 33.455 0 0 0 0 0 0 0 0 0 0
    PROST20094000 0 0 27.644 0 0 0 0 0 0 0 0 0 0
    PROST20097310 0 0 0 0 0 0 0 39.281 0 0 0 0 0
    PROST20097840 0 16.947 0 0 0 0 0 0 23.921 16.005 0 0 0
    PROST20103820 0 0 0 0 0 39.227 0 0 0 0 0 0 0
    PROST20114100 0 0 0 0 0 39.227 0 0 0 0 0 0 0
    PROST20130320 0 12.898 0 12.198 0 0 0 0 0 12.181 0 0 0
    PROST20151370 0 0 0 0 0 39.227 0 0 0 0 0 0 0
    PUAEN10000650 0 0 0 4.545 3.46 0 3.762 8.786 3.392 0 3.564 0 0
    PUAEN10001640 0 3.714 0 0 0 0 0 0 0 3.508 0 0 0
    PUAEN20003120 15.692 0 0 0 0 0 0 0 0 0 0 0 0
    SKNMC20006350 0 0 0 0 0 0 0 0.653 0 0 0 0 2.835
    SKNSH10001010 0 0 8.649 5.695 8.669 5.492 9.427 5.504 0 11.373 8.93 0 0
    SKNSH20007160 15.069 10.236 0 0 0 0 0 9.356 0 9.667 15.179 0 0
    SKNSH20030640 0 0 0 0 26.755 0 0 16.987 0 0 0 0 0
    SKNSH20094350 19.559 0 0 0 0 0 0 0 0 0 0 0 0
    SMINT20000070 0 18.929 0 0 0 0 0 0 0 0 0 0 0
    SMINT20002320 0 0 39.676 0 0 0 0 0 0 0 0 0 0
    SMINT20030740 2.994 0 0 0 0 0 0 0 0 0 0 0 0
    SMINT20039050 0 0 0 0 0 0 0 5.94 0 0 0 0 25.802
    SMINT20045890 0 0 0 0 0 11.467 0 0 0 0 0 0 0
    SMINT20047290 20.756 0 0 0 0 0 0 0 0 0 0 0 0
    SMINT20048720 0 0 0 16.241 0 0 0 7.849 12.12 0 0 0 0
    SMINT20056240 12.1 16.438 0 0 0 0 0 0 0 0 0 0 0
    SMINT20077920 29.636 11.503 0 5.439 0 5.246 18.009 0 8.118 5.432 8.529 0 0
    SMINT20088690 0 0 0 0 0 0 0 0 50.098 0 0 0 0
    SMINT20089210 5.552 0 0 7.133 0 0 0 0 0 7.123 22.369 10.807 0
    SMINT20089600 0 0 0 0 0 18.533 0 0 28.682 0 0 0 0
    SMINT20094150 0 0 0 0 0 0 0 0 0 0 0 0 73.849
    SPLEN20005160 0 0 38.129 0 0 0 0 0 0 25.071 0 0 0
    SPLEN20005370 0 0 0 0 0 0 69.313 0 0 0 0 0 0
    SPLEN20012450 0 0 0 0 0 0 0 0 0 0 0 0 34.138
  • TABLE 34
    SPLEN20024930 0 0 0 24.956 0 0 0 0 0 12.461 0 0 0
    SPLEN20040780 32.496 0 31.704 0 0 0 0 0 0 0 0 0 0
    SPLEN20048800 0 0 0 0 0 0 0 0.678 0 0 0 0 0
    SPLEN20055600 0 0 0 0 0 0 0 0 67.066 0 0 0 0
    SPLEN20057830 0 0 0 0 0 0 32.073 18.727 0 0 0 0 0
    SPLEN20063250 0 0 0 0 0 0 0 0 0 0 4.267 0 0
    SPLEN20071820 0 0 0 0 0 0 0 0 0 0 37.578 0 0
    SPLEN20073880 0 0 0 0 0 0 0 0 28.031 0 0 0 0
    SPLEN20076470 8.519 0 0 0 0 0 0 0 0 0 0 0 0
    SPLEN20104690 0 0 0 0 0 0 0 56.874 0 0 0 0 0
    SPLEN20114190 0 0 0 0 0 0 0 0 0 57.672 0 0 0
    SPLEN20125230 0 0 0 21.397 0 0 0 41.362 0 0 0 0 0
    SPLEN20135030 0 0 0 0 0 0 0 20.858 0 0 0 0 0
    SPLEN20136700 0 0 0 22.036 0 0 0 0 0 22.006 0 0 0
    SPLEN20175920 0 0 0 57.706 0 0 0 0 0 0 0 0 0
    SPLEN20181570 3.585 0 0 0 0 0 0 0 0 0 0 0 0
    SPLEN20183020 0 0 0 0 0 0 0 0 0 21.246 0 0 0
    SPLEN20187490 0 0 0 0 0 0 0 22.776 0 0 0 0 0
    SPLEN20193490 0 0 0 0 0 0 0 0 0 57.672 0 0 0
    SPLEN20193790 0 0 0 0 0 0 0 0 0 0 0 0 10.329
    SPLEN20197740 0 0 0 0 0 0 0 0 0 0 33.067 0 0
    SPLEN20200070 0 0 0 0 67.502 0 0 0 0 0 0 0 0
    SPLEN20200340 0 0 0 0 40.827 0 0 0 0 0 0 0 0
    TESOP10000350 0 0 0 0 0 0 0 2.374 0 0 0 3.721 0
    TESTI20005980 0 0 0 28.345 0 0 0 0 0 0 0 0 0
    TESTI20030440 0 0 0 0 0 0 0 0 0 0 27.24 0 0
    TESTI20030610 0 0 0 0 0 7.709 0 7.726 0 0 0 0 0
    TESTI20031410 0 0 0 0 0 19.238 0 0 0 0 0 15.113 0
    TESTI20035330 4.698 0 0 0 0 5.821 0 5.835 0 0 0 0 25.343
    TESTI20047370 0 0 0 0 0 0 0 0 3.037 0 0 0 0
    TESTI20050400 56.537 0 0 0 0 0 0 0 0 0 0 0 0
    TESTI20050720 0 0 0 6.04 0 0 0 0 0 0 0 0 0
    TESTI20053780 56.537 0 0 0 0 0 0 0 0 0 0 0 0
    TESTI20057430 0 0 0 5.84 0 0 0 5.644 0 0 0 0 0
    TESTI20057590 0 0 0 0 0 5.433 0 0 8.409 0 0 0 0
    TESTI20057840 0 0 0 0 0 0 0 61.764 0 0 0 0 0
    TESTI20057880 0 0 0 15.638 0 0 0 0 0 0 0 0 0
  • TABLE 35
    TESTI20059080 0 5.993 0 0 25.882 0 0 5.478 8.458 0 0 0 0
    TESTI20061200 0 9.745 0 0 0 8.888 0 0 0 0 0 0 0
    TESTI20062580 0 0 0 0 0 0 31.15 0 28.084 0 29.506 0 0
    TESTI20063410 0 0 0 9.861 0 9.51 0 0 14.718 9.848 0 0 0
    TESTI20064530 0 0 0 0 0 2.635 0 0 0 5.458 0 0 0
    TESTI20066280 0 0 0 0 0 0 33.259 0 0 0 0 0 0
    TESTI20067480 9.289 6.31 0 11.934 0 0 0 5.768 0 0 0 0 0
    TESTI20071630 0 0 0 62.564 0 0 0 0 0 0 0 0 0
    TESTI20079980 6.472 8.793 6.314 0 0 4.009 6.883 12.056 0 4.152 0 0 0
    TESTI20081890 0 0 0 0 0 61.711 0 0 0 0 0 0 0
    TESTI20089290 0 63.862 0 0 0 0 0 0 0 0 0 0 0
    TESTI20090180 0 0 0 21.786 0 0 0 0 0 0 0 0 0
    TESTI20105130 2.549 0 2.487 0 4.986 0 0 1.583 0 1.635 0 0 0
    TESTI20106170 0 18.661 13.402 0 0 8.51 14.608 0 0 26.436 0 0 0
    TESTI20121040 0 0 0 18.021 0 0 0 0 0 0 0 0 0
    TESTI20150920 0 0 0 0 17.606 0 0 0 17.261 0 18.135 0 0
    TESTI20169500 17.008 0 0 0 0 0 0 0 0 0 0 0 0
    TESTI20193080 0 0 0 0 0 0 0 0 0 62.532 0 0 0
    TESTI20215310 0 0 0 0 0 0 0 0 0 0 0 71.689 0
    TESTI20221790 0 0 0 0 0 0 0 37.573 0 0 0 0 0
    TESTI20245860 0 0 0 62.564 0 0 0 0 0 0 0 0 0
    TESTI20252690 0 33.792 0 0 0 0 0 0 0 0 0 0 0
    TESTI20254090 0 0 0 0 0 12.041 0 24.136 18.635 0 0 0 0
    TESTI20261160 0 0 0 0 0 0 0 35 0 0 0 0 0
    TESTI20262150 0 0 42.353 0 0 0 0 0 0 0 0 0 0
    TESTI20274960 0 0 0 0 0 0 0 0 0 38.341 0 0 0
    THYMU20007750 0 0 0 29.606 0 0 0 0 0 0 0 0 0
    THYMU20009460 0 16.274 0 0 0 0 0 0 0 0 0 0 0
    THYMU20009710 0 0 0 0 0 0 0 0 0 0 0 0 83.62
    THYMU20019260 15.885 0 0 0 0 0 0 0 30.461 0 0 0 0
    THYMU20028410 13.579 0 0 0 0 16.825 0 0 0 0 0 0 0
    THYMU20030460 0 0 0 4.612 0 0 0 0 0 4.606 0 0 0
    THYMU20031330 0 0 0 0 0 0 0 0 0 0 0 0 39.843
    THYMU20043440 0 0 0 0 0 29.394 0 0 0 0 0 0 0
    THYMU20044100 0 0 0 28.394 0 0 0 27.444 0 0 0 0 0
    THYMU20044520 0 28.839 0 0 0 26.302 0 0 0 0 0 0 0
    THYMU20049060 0 0 0 0 0 0 0 0 64.474 0 0 0 0
  • TABLE 36
    THYMU20055460 5.716 0 5.577 0 0 0 0 0 0 3.667 0 11.127 0
    THYMU20055740 0 0 0 54.873 0 0 0 0 0 0 0 0 0
    THYMU20071120 3.627 0 3.539 0 0 0 0 0 0 0 0 0 0
    THYMU20078020 0 56.251 0 0 0 0 0 0 0 0 0 0 0
    THYMU20089900 0 0 0 0 0 0 0 0 0 0 30.29 0 0
    THYMU20091040 0 0 0 0 0 25.102 0 0 19.425 0 20.408 0 0
    THYMU20104480 0 0 22.379 0 0 14.21 0 0 0 0 0 0 0
    THYMU20120240 7.548 0 0 0 0 0 0 0 0 0 0 0 0
    THYMU20139160 1.433 0.649 0.932 1.841 1.868 2.958 2.031 2.965 3.663 2.451 0 0 0
    THYMU20143230 0 0 0 0 0 53.973 0 0 0 0 0 0 0
    THYMU20150190 0 0 0 0 0 0 0 0 15.366 0 0 0 43.225
    THYMU20157620 0 0 0 0 0 0 0 10.687 0 0 0 16.752 0
    THYMU20176010 48.624 0 0 0 0 0 0 0 0 0 0 0 0
    TKIDN10001920 15.885 0 0 0 0 0 0 0 30.461 0 0 0 0
    TRACH20012490 0 0 0 0 0 8.484 0 0 0 0 0 0 0
    TRACH20021000 0 14.835 0 0 0 0 0 0 0 0 0 0 58.903
    TRACH20026640 0 0 0 7.419 0 0 0 0 0 0 0 0 0
    TRACH20058000 0 0 0 0 0 23.543 0 0 0 0 0 0 0
    TRACH20090060 0 0 0 0 0 6.122 0 0 0 0 0 0 0
    TRACH20159390 0 0 0 0 0 0 0 34.053 0 0 0 0 0
    UMVEN10001380 0 0 3.528 0 0 0 0 0 0 0 0 0 0
    UTERU10001060 15.424 0 0 0 0 0 32.805 0 0 0 0 0 0
    UTERU20000230 0 0 0 21.808 0 0 0 0 0 21.777 0 0 0
    UTERU20000950 1.882 2.557 0 2.418 0 2.332 4.002 0 0 4.829 0 0 0
    UTERU20026620 5.456 7.413 10.647 0 0 0 0 0 0 0 0 0 0
    UTERU20041970 0 0 3.112 0 0 3.953 0 0 0 0 0 3.105 0
    UTERU20065470 0 0 0 0 0 0 0 0 0 0 49.42 0 0
    UTERU20079240 0 0 0 0 19.675 0 0 0 0 0 20.266 19.583 0
    UTERU20083020 0 0 0 0 0 43.664 8.006 4.675 7.218 4.83 7.584 7.328 0
    UTERU20089300 0 0 0 0 0 0 0 0 0 0 0 0 72.345
    UTERU20089390 8.519 0 0 0 0 0 0 0 0 0 0 0 0
    UTERU20095100 19.272 0 0 0 0 0 40.989 0 0 0 0 0 0
    UTERU20102260 0 0 0 15.526 0 0 0 0 0 0 0 0 0
    UTERU20103200 0 0 0 0 0 0 0 0 48.185 0 0 0 0
    UTERU20127150 0 0 0 0 0 0 0 37.588 0 0 0 0 0
    UTERU20128560 0 0 0 11.256 0 0 0 0 0 0 0 0 0
  • TABLE 37
    Clone ID FEHRT HEART
    BRAMY20043630 0 7.465
    BRAMY20072870 0 76.411
    BRAMY20227860 0 2.943
    BRAWH20093070 0 25.522
    BRCAN10001680 0 14.799
    FCBBF30053300 86.185 0
    FEBRA20078800 0 33.301
    FEBRA20090220 0 9.681
    HCHON20000870 0 23.022
    HEART10001420 0 100
    HEART10001490 0 14.37
    HEART20009590 0 100
    HEART20019310 0 100
    HEART20022200 0 100
    HEART20031680 0 100
    HEART20047640 0 100
    HEART20063100 0 100
    HEART20082570 0 100
    HLUNG20083960 0 40.294
    PLACE60088240 0 67.95
    PLACE60120280 0 50.712
    PROST20016760 0 8.491
    PROST20035170 0 23.745
    PROST20062820 0 67.646
    PROST20127450 0 48.135
    SKMUS20006790 0 5.186
    SKMUS20008730 0 27.003
    TESTI20270130 0 83.925
  • TABLE 38
    Clone ID FEKID KIDNE
    ASTRO20009140 0 19.518
    BGGI120010750 0 4.532
    BRACE20054480 0 29.719
    BRACE20062580 0 2.613
    BRACE20219360 0 59.494
    BRAMY20001510 68.103 0
    BRAMY20003540 0 4.676
    BRAMY20003880 0 16.882
    BRAMY20043630 0 3.51
    BRAMY20204270 0 3.618
    CTONG20033750 0 59.93
    CTONG20039370 0 59.93
    CTONG20045500 0 59.93
    FCBBF20023490 0 14.59
    FEBRA20039260 0 7.084
    FEBRA20040290 0 7.711
    HEART10001490 0 20.269
    HLUNG20041590 0 4.744
    HLUNG20068120 0 11.84
    HLUNG20072450 88.657 3.599
    HLUNG20083960 0 18.946
    KIDNE20011600 0 100
    KIDNE20016360 0 59.589
    KIDNE20024380 0 100
    KIDNE20027980 0 100
    KIDNE20080690 0 5.861
    KIDNE20081170 0 100
    KIDNE20083150 0 100
    KIDNE20083620 0 100
    KIDNE20084030 0 40.03
    KIDNE20084040 0 34.084
    KIDNE20084730 0 100
    KIDNE20084800 0 100
    KIDNE20086490 0 87.61
    KIDNE20086660 0 47.013
    KIDNE20086970 0 100
    KIDNE20087880 0 28.683
    KIDNE20088240 0 100
    KIDNE20089870 0 3.987
    KIDNE20091090 0 100
    KIDNE20094260 0 100
    KIDNE20094670 0 59.494
    KIDNE20095530 0 100
    KIDNE20133460 0 100
    KIDNE20133880 0 100
    KIDNE20134130 0 65.363
    KIDNE20134890 0 100
    KIDNE20137310 0 100
    KIDNE20138450 0 38.971
    KIDNE20140870 0 22.93
    KIDNE20141120 0 100
    KIDNE20141700 0 100
    KIDNE20142680 0 100
    KIDNE20142900 0 31.732
    KIDNE20143200 0 100
    KIDNE20147170 0 100
    KIDNE20148080 0 100
    KIDNE20149780 0 60.365
    KIDNE20150730 0 100
    KIDNE20152440 0 100
    KIDNE20154330 0 100
    KIDNE20154830 0 100
    KIDNE20155980 0 100
    KIDNE20157100 0 100
    KIDNE20160360 0 100
    KIDNE20160960 0 100
    KIDNE20163710 0 100
    KIDNE20165390 0 100
    KIDNE20169180 0 100
    KIDNE20170400 0 19.556
    KIDNE20173150 0 100
    KIDNE20173430 0 36.673
    KIDNE20176030 0 100
    KIDNE20181670 0 100
    KIDNE20182540 0 100
    KIDNE20186170 0 100
    KIDNE20188630 0 100
    KIDNE20189890 0 100
    KIDNE20189960 0 100
    KIDNE20191870 0 100
    OCBBF20174890 0 32.241
    PLACE60073090 0 10.501
    PLACE60181870 0 49.921
    PROST20016760 0 3.992
    PUAEN10000650 0 6.676
    SKNMC20006350 24.429 0
    SPLEN20017610 0 42.429
    SPLEN20063250 0 3.996
    SPLEN20126110 0 50.05
    SPLEN20135030 0 31.695
    TESTI20061200 0 13.537
    TESTI20262150 0 40.96
    THYMU10004280 0 3.534
    THYMU20139160 0 2.704
    TRACH20011010 0 10.647
  • TABLE 39
    Clone ID FELNG HLUNG
    BRAMY20001510 0 5.948
    BRAMY20043630 0 15.102
    BRAMY20204270 0 7.785
    BRAMY20227860 0 1.488
    CTONG20029030 0 28.504
    CTONG20168460 0 76.291
    CTONG20186290 0 61.67
    FEBRA20039260 0 7.62
    FEBRA20078800 0 33.686
    FEBRA20163980 0 38.327
    HCHON20000870 0 23.288
    HLUNG20008460 0 67.54
    HLUNG20009260 0 100
    HLUNG20009550 0 100
    HLUNG20010130 0 100
    HLUNG20011260 0 100
    HLUNG20011440 0 100
    HLUNG20011460 0 76.577
    HLUNG20012140 0 100
    HLUNG20014590 0 36.045
    HLUNG20015070 0 17.804
    HLUNG20015180 0 4.723
    HLUNG20020500 0 100
    HLUNG20020850 0 67.488
    HLUNG20021450 0 68.006
    HLUNG20023030 0 100
    HLUNG20024050 0 100
    HLUNG20025620 0 100
    HLUNG20028110 0 76.618
    HLUNG20029420 0 100
    HLUNG20029490 0 81.173
    HLUNG20030420 0 100
    HLUNG20030490 0 100
    HLUNG20030610 0 100
    HLUNG20031620 0 80.237
    HLUNG20032460 0 44.037
    HLUNG20033060 0 36.529
    HLUNG20033310 0 100
    HLUNG20033350 0 100
    HLUNG20034970 0 79.349
    HLUNG20037140 0 100
    HLUNG20037160 0 100
    HLUNG20037780 0 44.761
    HLUNG20038330 0 100
    HLUNG20041540 0 100
    HLUNG20041590 0 10.207
    HLUNG20042730 0 100
    HLUNG20045340 0 7.67
    HLUNG20047070 0 100
    HLUNG20050760 0 100
    HLUNG20051330 0 100
    HLUNG20052300 0 23.611
    HLUNG20054790 0 100
    HLUNG20055240 0 100
    HLUNG20056560 0 75.961
    HLUNG20057380 0 100
    HLUNG20059240 0 100
    HLUNG20060670 0 100
    HLUNG20063700 0 100
    HLUNG20065700 0 62.8
    HLUNG20065990 0 100
    HLUNG20067810 0 100
    HLUNG20068120 0 50.947
    HLUNG20069350 0 100
    HLUNG20070410 0 100
    HLUNG20072100 0 54.241
    HLUNG20072190 0 79.349
    HLUNG20072450 0 7.744
    HLUNG20074330 0 100
    HLUNG20079310 0 100
    HLUNG20081390 0 66.429
    HLUNG20081530 0 100
    HLUNG20082350 0 100
    HLUNG20083330 0 100
    HLUNG20083480 0 13.123
    HLUNG20083840 0 100
    HLUNG20083960 0 40.76
    HLUNG20084790 0 100
    HLUNG20085210 0 50.993
    HLUNG20088750 0 100
    HLUNG20092530 0 100
    HLUNG20093030 0 100
    HLUNG20094130 0 75.987
    KIDNE20142900 0 68.268
    PROST20016760 0 8.589
    PROST20052850 0 57.701
    SKNMC20006350 0 2.134
    SMINT20035050 0 6.135
    SPLEN20012450 0 25.695
    TESTI20057590 0 17.804
    TESTI20061200 0 29.123
    TESTI20067480 0 18.856
    TESTI20116050 0 30.168
    THYMU10004280 0 7.603
    THYMU20010180 0 79.349
    THYMU20139160 0 1.939
    TRACH20011010 0 22.907
    UTERU20016580 0 43.64
    UTERU20127030 0 66.318
  • TABLE 40
    Alteration of the expression level of each clone due to
    TNF-α stimulation to human monocyte cell line THP-1 and
    alteration of the expression level of each clone due to co-
    culture of gastric cancer cell line MKN45 with Helicobacter
    pylori. ctl, TNF_1h, and TNF_3h in the column of THP-1,
    respectively, indicate the relative mRNA expression levels in
    unstimulated THP-1, in the cell stimulated with 10 ng/mL TNF-α
    for 1 hour, and in the cell stimulated with 10 ng/mL TNF-α for 3
    hours; ctl, Hp, and ΔcagE in the column of MKN45 indicate the
    relative mRNA expression levels in MKN45 cultured without
    Helicobacter pylori, in the cells co-cultured with cag PAI-
    positive Helicobacter pylori (TN2) (at a ratio of MKN45:TN2 = 1:100
    cells (colonies)) for 3 hours, and in the cells co-
    cultured with the cagE mutant (TN2ΔcagE) (at a ratio of
    MKN45:TN2ΔcagE = 1:100 cells (colonies)) for 3 hours, respectively.
    [ATAC-PCR]
    THP-1 MKN45
    Clone name ctl TNF_1h TNF_3h ctl Hp ΔcagE
    ASTRO20045840 1.5 2.3 1.9 2.3 2.4 0.2
    ASTRO20055930 0.8 1.9 1.4 0.8 0.8 0.5
    ASTRO20088950 1.0 0.2 2.5 1.1 0.3 0.3
    BNGH420052350 2.2 2.2 0.0 0.5 0.5 3.2
    BRACE20052530 2.6 1.0 0.3 2.2 1.0 0.9
    BRACE20054080 0.8 1.1 1.0
    BRAMY20003880 1.5 0.9 0.6 1.2 0.0 1.3
    BRAMY20027390 0.6 4.2 0.1 2.9 0.4 0.1
    BRAMY20028530 0.5 3.4 4.1
    BRAMY20035380 1.3 0.9 0.8 0.5 1.7 0.5
    BRAMY20036530 1.1 0.3 0.3
    BRAMY20050940 0.4 0.0 0.0 0.2 0.2 1.0
    BRAMY20072440 0.5 0.5 0.1
    BRAMY20096930 3.8 5.2 4.7 1.7 2.4 1.7
    BRAMY20118410 0.8 3.7 0.8 2.7 0.0 0.0
    BRAMY20237190 0.0 2.3 0.1
    BRAWH20055330 2.5 4.7 2.8 1.2 1.3 0.0
    BRAWH20078620 1.9 1.2 1.0
    BRAWH20190530 0.6 0.1 0.0 0.3 0.0 0.0
    BRCAN20001480 1.0 3.4 4.1 1.4 1.6 0.6
    BRHIP10000720 0.3 1.8 1.4 0.9 0.0 1.7
    BRHIP10001040 0.9 0.7 0.1 0.0 0.1 0.0
    BRHIP20000210 0.6 0.6 0.0 2.0 0.3 0.0
    BRSSN20001970 0.8 1.4 1.3 0.8 0.7 0.5
    BRSSN20091190 0.6 0.1 0.8
    CD34C20001750 0.0 0.4 2.0
    CTONG20078340 0.3 2.6 1.6 0.9 0.7 2.4
    CTONG20079590 1.0 1.2 0.2 0.1 0.0 0.0
    CTONG20083980 0.0 0.0 0.0 1.3 1.8 1.9
    CTONG20085210 0.8 1.2 2.3 0.1 0.2 0.1
    DFNES20063460 1.7 3.6 2.7 1.3 2.0 0.1
    DFNES20072990 1.4 1.9 2.0 5.0 4.9 4.2
    FCBBF20029280 1.8 5.5 3.8 2.3 2.2 2.3
    FCBBF20032930 0.1 0.1 0.0 1.7 0.5 0.5
    FCBBF20036360 0.6 0.7 0.4 0.4 0.2 0.2
    FCBBF30022680 2.9 1.0 0.3 2.9 1.0 0.3
    FCBBF30078600 1.1 2.6 0.6
    FCBBF30105080 1.8 1.6 1.9 0.2 0.1 0.0
    FCBBF30169870 1.1 1.2 0.2 1.6 0.3 0.3
    FCBBF30225930 2.2 0.8 1.0 1.1 0.7 0.2
    FCBBF50000610 2.1 2.8 2.2 2.0 2.2 1.3
    FEBRA20007820 0.0 1.7 2.4 2.1 1.4 1.2
    FEBRA20031280 0.1 1.8 4.5 0.5 0.0 0.0
    FEBRA20031810 1.4 3.9 3.5 1.5 2.1 1.9
    FEBRA20039260 2.0 3.0 2.5
    FEBRA20046280 1.3 0.3 0.3
    FEBRA20084750 2.5 2.2 0.3
    FEBRA20182030 3.0 4.0 4.2 1.6 0.3 0.7
    HLUNG20041540 0.0 2.2 2.2 1.9 2.4 0.2
    HLUNG20092530 0.3 0.3 3.1 0.2 0.2 0.9
    KIDNE20084030 1.6 0.1 0.3 0.1 0.0 0.0
    KIDNE20084800 0.6 0.3 0.0 0.5 0.5 1.1
    KIDNE20134130 0.4 0.4 0.5 2.3 1.2 1.6
    KIDNE20182540 1.1 0.3 0.3
    KIDNE20186170 0.0 0.0 0.0 0.6 0.0 0.0
    KIDNE20188630 1.5 0.5 0.5 0.4 0.3 0.0
    LIVER20007750 1.3 1.8 0.3 1.9 0.7 0.0
    MESAN20021220 1.7 2.6 1.6 2.3 0.9 0.3
    MESAN20084150 0.8 2.6 2.2 1.7 2.1 1.1
    NT2NE20059210 1.4 0.4 0.1
    NT2NE20082130 1.8 1.3 0.5 1.9 0.3 0.3
    NT2NE20092950 1.3 2.7 3.4 1.7 2.4 1.8
    NT2RP70031070 0.3 0.9 1.4 0.4 0.4 0.0
    OCBBF20012520 0.3 0.3 1.3 0.9 0.2 1.2
    OCBBF20110210 4.5 1.8 0.5 0.5 0.5 4.5
    OCBBF20110730 0.4 0.5 0.3 0.1 0.0 0.0
    OCBBF20155030 1.1 1.1 0.9 2.5 0.8 0.3
    OCBBF20165900 1.7 4.4 4.4 1.9 3.3 1.1
    OCBBF20170350 0.9 5.4 0.3 0.3 1.7 1.5
    OCBBF20176650 0.5 1.3 0.5 0.7 0.7 0.0
    PLACE60006300 0.8 3.2 1.0 0.5 0.5 0.9
    PLACE60061370 2.7 0.8 1.5 1.2 1.0 1.3
    PROST20011160 0.2 1.7 2.0 1.3 5.5 1.7
    PROST20041460 2.9 0.1 1.5 0.6 0.0 0.0
    PROST20065100 1.4 1.9 1.6 5.3 0.0 0.0
    PROST20075280 1.7 0.5 0.5 2.6 0.5 0.5
    PROST20106060 0.2 0.2 2.0 1.0 0.6 0.7
    PROST20110120 1.2 0.6 0.5
    SKMUS20091900 1.2 1.6 0.3 1.2 2.6 0.3
    SMINT20024140 0.0 0.1 0.0
    SMINT20092160 0.5 0.7 0.3 1.3 1.2 0.3
    SPLEN20040780 1.0 2.8 1.9 0.3 0.8 0.1
    SPLEN20110860 2.4 0.1 7.6 1.4 0.1 0.1
    SPLEN20177400 0.8 3.3 1.3 1.3 0.7 0.3
    TESTI20038240 0.1 0.0 0.0
    TESTI20043130 0.0 0.1 0.7
    TESTI20046540 1.1 0.8 0.2 1.1 0.8 0.3
    TESTI20047370 0.4 0.4 0.5 0.6 0.0 0.5
    TESTI20057200 2.5 0.0 1.2 1.1 0.4 0.3
    TESTI20057590 0.1 0.1 0.0 3.8 3.5 2.2
    TESTI20113940 5.2 0.2 0.2 4.4 0.4 0.4
    TESTI20149880 2.2 0.2 2.2
    TESTI20151800 2.1 3.3 2.3 2.5 1.0 0.3
    TESTI20173050 0.8 0.6 0.5 1.8 1.1 1.0
    TESTI20198600 2.2 0.2 2.2
    TESTI20257910 1.2 0.3 0.3 1.2 0.2 0.7
    TESTI20262940 1.5 1.1 0.2 1.1 1.3 0.2
    THYMU20046770 1.7 0.5 0.5
    THYMU20058550 1.9 0.1 0.1
    THYMU20062520 0.0 0.0 0.7 0.2 0.3 0.1
    THYMU20062770 1.6 1.0 0.3
    THYMU20078240 0.3 1.7 2.9 0.0 1.0 0.1
    THYMU20150190 0.2 0.2 0.6 1.4 0.5 1.9
    TRACH20125620 1.1 2.5 1.5 1.4 1.4 1.0
    TRACH20149740 9.4 9.4 0.9 1.6 2.1 0.6
    TRACH20190460 2.0 3.3 3.1 0.2 1.1 0.2
    UTERU20045200 1.4 2.6 3.9 0.9 2.1 2.5
    UTERU20064120 0.6 2.7 2.0 0.6 1.7 0.4
    UTERU20103200 0.1 0.0 0.9 2.4 1.7 0.9
    ADRGL20046760 0.5 0.5 0.5
    ASTRO20055530 0.7 2.4 1.7 0.8 2.1 1.6
    BRAMY20076130 0.1 1.4 0.2 0.1 0.0 0.0
    CTONG20170940 1.6 0.8 0.3 0.5 9.9 0.5
    FCBBF20033360 0.1 0.4 1.4 6.4 0.3 0.7
    FCBBF30257370 2.7 0.3 0.3 2.2 0.1 2.2
    FCBBF50001650 1.0 1.6 1.2 1.3 1.0 0.9
    FEBRA20040290 0.4 1.9 1.1 0.4 1.5 1.4
    FEBRA20063720 2.9 3.3 3.1 1.5 0.7 1.4
    FEBRA20098040 2.5 2.1 1.5 4.2 0.0 0.3
    FEBRA20108580 1.4 2.8 2.8 0.7 0.2 0.2
    MESAN20021860 0.1 1.2 0.2 0.9 1.0 0.9
    MESAN20067430 0.8 3.0 1.5 0.0 0.3 0.0
    NT2NE20045190 0.7 0.2 0.2 0.8 0.6 0.2
    PROST20016760 1.1 3.4 2.3
    SKNSH20007160 0.6 0.3 0.2 1.1 0.7 0.6
    SMINT20006020 2.5 1.0 0.3 2.4 0.3 0.3
    TESTI20059370 0.0 0.2 0.3 0.0 0.0 0.0
    TESTI20103690 0.0 0.0 0.0 0.8 0.3 0.3
    TESTI20254480 0.0 0.1 0.6 0.8 0.6 0.0
    THYMU10004280 0.2 2.2 0.2 0.2 1.1 1.4
    THYMU20030460 0.2 0.6 0.2 0.6 0.8 2.4
    TRACH20090060 0.5 0.3 2.0 0.0 6.8 1.7
    UTERU20041970 1.6 1.1 1.5 0.0 3.5 2.4
    BRAMY20125360 0.8 1.6 1.1 0.0 0.0 0.0
    OCBBF20142290 0.2 0.9 0.3 0.1 0.4 0.0
    SKMUS20006790 0.7 0.5 0.3 1.0 0.8 0.7
    TESTI20030610 0.1 2.0 1.7 0.0 0.3 0.0
    UTERU20026620 0.4 4.2 4.2 2.4 2.7 0.9

    Homology Search Result Data
  • Data obtained by the homology search for full-length nucleotide sequences and deduced amino acid sequences.
  • In the result of the search shown below, both units, aa and bp, are used as length units for the sequences to be compared.
  • Each data includes Clone name, Definition in hit data, P value, Length of sequence to be compared, Homology, and Accession number (No.) of hit data. These items are shown in this order and separated by a double-slash mark, //.
    • ADRGL20020290//Human placental equilibrative nucleoside transporter 1 (hENT1) mRNA, complete cds.//1.70E-240//456aa//100%//U81375
    • ADRGL20021910//Homo sapiens transmembrane protein B7-H2 ICOS ligand mRNA, complete cds.//2.50E-88//168aa//100%//AAG01176
    • ADRGL20022600//DIAPHANOUS PROTEIN HOMOLOG 1 (P140MDIA).//2.00E-07//121aa//36%//008808
    • ADRGL20023920//ABC1 PROTEIN HOMOLOG PRECURSOR.//1.40E-98//467aa//45%//Q92338
    • ADRGL20026790//Homo sapiens PLIC-1 mRNA, complete cds.//6.10E-05//169aa//31%//AF293384
    • ADRGL20027530
    • ADRGL20036380
    • ADRGL20036840//HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN H PRECURSOR (HLA-AR) (HLA-12.4).//7.30E-68//131aa//96%//P01893
    • ADRGL20040310
    • ADRGL20040770
    • ADRGL20046760
    • ADRGL20047080
    • ADRGL20047770
    • ADRGL20057560
    • ADRGL20059610//GLUCOSYLCERAMIDASE PRECURSOR (EC 3.2.1.45) (BETA-GLUCOCEREBROSIDASE) (ACID BETA-GLUCOSIDASE) (D-GLUCOSYL-N-ACYLSPHINGOSINE GLUCOHYDROLASE) (ALGLUCERASE) (IMIGLUCERASE).//3.00E-94//188aa//93%//P04062
    • ADRGL20062330//Homo sapiens trabeculin-alpha mRNA, complete cds.//1.10E-128//439aa//58%//AF141968
    • ADRGL20063770
    • ADRGL20066770//elastin microfibril interface located protein [Homo sapiens].//3.00E-31//210aa//44%//NP—008977
    • ADRGL20067320
    • ADRGL20079060//Mus musculus mRNA for Ky protein (muscle-specific protein).//3.80E-266//281aa//84%//AJ293727
    • ADRGL20095330
    • ASTRO20001910//Rattus norvegicus mRNA for annexin V-binding protein (ABP-10), partial cds.//2.20E-57//153aa//73%//D64062
    • ASTRO20003720
    • ASTRO20004820
    • ASTRO20006530//Homo sapiens hook1 protein (HOOK1) mRNA, complete cds.//1.80E-94//383aa//55%//AF044923
    • ASTRO20009140//PUTATIVE COMPETENCE-DAMAGE PROTEIN.//2.70E-06//167aa//29%//P46323
    • ASTRO20010010
    • ASTRO20010290
    • ASTRO20012270
    • ASTRO20020240
    • ASTRO20020350
    • ASTRO20022020
    • ASTRO20026320//NAM7 PROTEIN (NONSENSE-MEDIATED mRNA DECAY PROTEIN 1) (UP-FRAMESHIFT SUPPRESSOR 1).//1.80E-47//432aa//33%//P30771
    • ASTRO20027330
    • ASTRO20038400//Homo sapiens zinc finger homeobox protein ZHX1 mRNA, complete cds.//3.40E-78//282aa//42%//AF106862
    • ASTRO20045840
    • ASTRO20046280//PSU1 PROTEIN.//1.30E-42//228aa//36%//P53550
    • ASTRO20047510
    • ASTRO20050810//L-RIBULOKINASE (EC 2.7.1.16).//1.10E-43//512aa//30%//P94524
    • ASTRO20052420//PROBABLE GUANINE NUCLEOTIDE REGULATORY PROTEIN TIM (ONCOGENE TIM) (P60 TIM) (TRANSFORMING IMMORTALIZED MAMMARY ONCOGENE).//4.80E-151//408aa//76%//Q12774
    • ASTRO20053430//BAND 4.1-LIKE PROTEIN 4 (NBL4 PROTEIN).//1.80E-58//307aa//38%//057457
    • ASTRO20055530
    • ASTRO20055570//MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) (ASCR).//5.40E-72//137aa//100%//P04156
    • ASTRO20055930
    • ASTRO20058960//DNA damage inducible protein homolog—fission yeast (Schizosaccharomyces pombe)//1.90E-14//205aa//31%//T39541
    • ASTRO20069200
    • ASTRO20075150//TNF RECEPTOR ASSOCIATED FACTOR 3 (CD40 RECEPTOR ASSOCIATED FACTOR 1) (CRAF1) (CD40 BINDING PROTEIN) (CD40BP) (LMP1 ASSOCIATED PROTEIN) (LAP1).//1.00E-25//60aa//98%//Q13114
    • ASTRO20076660
    • ASTRO20085080//TIPD PROTEIN.//1.80E-58//307aa//37%//015736
    • ASTRO20088950//LACTASE-PHLORIZIN HYDROLASE PRECURSOR (LACTASE-GLYCOSYLCERAMIDASE) [INCLUDES: LACTASE (EC 3.2.1.108); PHLORIZIN HYDROLASE (EC 3.2.1.62)].//7.80E-85//331aa//48%//P09848
    • ASTRO20089600//Mus musculus sacsin gene, complete cds.//1.10E-05//198aa//26%//AF193557
    • ASTRO20090680//M. musculus mRNA for IB3/5-polypeptide.//1.60E-173//412aa//78%//X79131
    • ASTRO20091180
    • ASTRO20091770
    • ASTRO20141740
    • BGGI120000670//Rattus norvegicus myosin heavy chain Myr 8b mRNA, complete cds.//1.60E-05//86aa//36%//AY004215
    • BGGI120010750//Rattus norvegicus mRNA for SECIS binding protein 2 (sbp2 gene).//7.90E-305//812aa//71%//AJ251245
    • BNGH410000570
    • BNGH420008150//Human SH3 domain-containing proline-rich kinase (sprk) mRNA, complete cds.//3.40E-139//326aa//82%//U07747
    • BNGH420014060
    • BNGH420015760//Mus musculus mRNA for JNK-binding protein JNKBP1, complete cds.//1.60E-130//381aa//60%//AB029482
    • BNGH420021680
    • BNGH420023870//RIBONUCLEASE INHIBITOR.//4.70E-41//314aa//34%//P10775
    • BNGH420024870
    • BNGH420035290//MYOSIN HEAVY CHAIN KINASE B (EC 2.7.1.129) (MHCK B).//7.60E-37//273aa//35%//P90648
    • BNGH420036410
    • BNGH420040760
    • BNGH420042910
    • BNGH420045380
    • BNGH420046790//immunoglobulin lambda light chain variable region [Homo sapiens].//5.00E-47//84aa//100%//AAG24674
    • BNGH420052350
    • BNGH420059680//DIPZ PROTEIN.//3.00E-13//166aa//31%//Q10801
    • BNGH420061350
    • BNGH420062340
    • BNGH420070370//ZINC FINGER PROTEIN GLI1 (GLI).//3.20E-65//165aa//59%//P47806
    • BNGH420074600//DNA-DIRECTED RNA POLYMERASE III 128 KDA POLYPEPTIDE (EC 2.7.7.6) (RNA POLYMERASE III SUBUNIT 2).//5.40E-214//522aa//72%//P25167
    • BNGH420075940
    • BNGH420077980//Rattus norvegicus ankyrin binding cell adhesion molecule neurofascin mRNA, alternatively spliced form, partial cds.//0//588aa//98%//U81036
    • BNGH420085100
    • BNGH420086030//N-CHIMAERIN (NC) (N-CHIMERIN) (ALPHA CHIMERIN) (A-CHIMAERIN).//2.30E-21//130aa//40%//P15882
    • BNGH420087430//Mus musculus mRNA 1 for phtf protein.//5.80E-118//237aa//57%//AJ133721
    • BRACE10000510//KERATIN, ULTRA HIGH-SULFUR MATRIX PROTEIN (UHS KERATIN).//4.70E-12//132aa//37%//P26371
    • BRACE20003310//ZINC FINGER PROTEIN 85 (ZINC FINGER PROTEIN HPF4) (HTF1).//1.00E-205//504aa//71%//Q03923
    • BRACE20007330//RING CANAL PROTEIN (KELCH PROTEIN).//4.60E-66//562aa//31%//Q04652
    • BRACE20009050
    • BRACE20014450//Mus musculus mRNA for Ndr1 related protein Ndr2, complete cds.//3.20E-150//291aa//95%//AB033921
    • BRACE20017790
    • BRACE20018810
    • BRACE20025820
    • BRACE20038920
    • BRACE20050870//PRE-mRNA SPLICING HELICASE BRR2 (EC 3.6.1.-).//8.40E-59//584aa//31%//P32639
    • BRACE20051600
    • BRACE20051930//NEUROPILIN PRECURSOR (A5 PROTEIN) (A5 ANTIGEN).//5.50E-20//179aa//30%//P28824
    • BRACE20052430//Homo sapiens AMSH mRNA, complete cds.//4.30E-75//272aa//53%//U73522
    • BRACE20052530
    • BRACE20054080
    • BRACE20054480
    • BRACE20054600//Xenopus laevis mRNA for Kielin, complete cds.//4.30E-70//205aa//60%//AB026192
    • BRACE20055560
    • BRACE20057870
    • BRACE20059110
    • BRACE20059810
    • BRACE20061620//ZINC-BINDING PROTEIN A33.//3.60E-30//329aa//28%//Q02084
    • BRACE20062580
    • BRACE20063540//MEROZOITE SURFACE PROTEIN CMZ-8 (FRAGMENT).//1.60E-10//164aa//35%//P09125
    • BRACE20065470//Xenopus laevis ubiquitin-like fusion protein mRNA, complete cds.//6.70E-63//170aa//71%//L08474
    • BRACE20066360
    • BRACE20068710
    • BRACE20069000//CLN3 PROTEIN (BATTENIN) (BATTEN'S DISEASE PROTEIN).//1.20E-147//279aa//100%//Q13286
    • BRACE20069110
    • BRACE20069440
    • BRACE20079200//Xenopus laevis mRNA for Kielin, complete cds.//3.10E-15//63aa//58%//AB026192
    • BRACE20079370//microtubule associated-protein orbit [Drosophila melanogaster].//8.00E-42//282aa//36%//BAA94248
    • BRACE20097540//Homo sapiens protein serine/threonine phosphatase 4 regulatory subunit 1 (PP4R1) mRNA, complete cds.//2.80E-96//193aa//96%//AF111106
    • BRACE20098860
    • BRACE20099070
    • BRACE20194670//UDP-GALACTOSE TRANSLOCATOR (UDP-GALACTOSE TRANSPORTER) (UGT) (UDP-GAL-TR).//1.40E-32//72aa//98%//P78381
    • BRACE20196180//Homo sapiens HMG domain protein HMGX2 (HMGX2) mRNA, complete cds.//6.90E-154//235aa//91%//AF146223
    • BRACE20196960
    • BRACE20200770//PROTEIN MOV-10.//3.30E-24//113aa//50%//P23249
    • BRACE20200970
    • BRACE20204670//PROTEIN-TYROSINE PHOSPHATASE ALPHA PRECURSOR (EC 3.1.3.48) (R-PTP-ALPHA).//4.30E-237//428aa//99%//P18433
    • BRACE20205840
    • BRACE20207420
    • BRACE20212450
    • BRACE20215410//PROTEIN-TYROSINE PHOSPHATASE YVH1 (EC 3.1.3.48) (PTPASE YVH1).//2.90E-08//136aa//31%//Q02256
    • BRACE20216700
    • BRACE20216950//4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN (4F2HC) (LYMPHOCYTE ACTIVATION ANTIGEN 4F2 LARGE SUBUNIT) (4F2 HEAVY CHAIN ANTIGEN) (CD98 ANTIGEN).//4.80E-66//94aa//90%//P08195
    • BRACE20219360
    • BRAMY10000980
    • BRAMY10001730
    • BRAMY20000210
    • BRAMY20000250
    • BRAMY20001510//Homo sapiens RING zinc finger protein (RZF) mRNA, complete cds.//3.80E-131//245aa//99%//AF037204
    • BRAMY20003540//1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1 (EC 3.1.4.11) (PLC-DELTA-1) (PHOSPHOLIPASE C-DELTA-1) (PLC-III).//0//745aa//99%//P51178
    • BRAMY20003880
    • BRAMY20005080//UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16 (EC 3.1.2.15) (UBIQUITIN THIOLESTERASE 16) (UBIQUITIN-SPECIFIC PROCESSING PROTEASE 16) (DEUBIQUITINATING ENZYME 16) (UBIQUITIN PROCESSING PROTEASE UBP-M).//2.70E-46//93aa//100%//Q9Y5T5
    • BRAMY20013670//PECANEX PROTEIN.//1.80E-84//300aa//56%//P18490
    • BRAMY20016780
    • BRAMY20020440
    • BRAMY20021580
    • BRAMY20023390
    • BRAMY20023640
    • BRAMY20024790
    • BRAMY20027390
    • BRAMY20027990//Homo sapiens NEDL1 mRNA for NEDD4-like ubiquitin ligase 1, complete cds.//4.60E-158//294aa//100%//AB048365
    • BRAMY20028530
    • BRAMY20028620//NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING] (EC 2.4.2.19) (QUINOLINATE PHOSPHORIBOSYLTRANSFERASE [DECARBOXYLATING]) (QAPRTASE).//9.70E-18//53aa//84%//Q15274
    • BRAMY20035380//ZINC TRANSPORTER 1 (ZNT-1).//5.60E-40//211aa//35%//Q62720
    • BRAMY20035830//Homo sapiens RCC1-like G exchanging factor RLG mRNA, complete cds.//3.60E-103//251aa//75%//AF060219
    • BRAMY20036530
    • BRAMY20036810
    • BRAMY20038980//INTRACELLULAR PROTEIN TRANSPORT PROTEIN US01.//3.40E-17//407aa//23%//P25386
    • BRAMY20039290
    • BRAMY20040580//ZINC FINGER PROTEIN 135.//1.70E-29//115aa//54%//P52742
    • BRAMY20043520
    • BRAMY20043630//Homo sapiens Ras-binding protein SUR-8 mRNA, complete cds.//1.30E-167//364aa//88%//AF068920 BRAMY20044920//UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4 (EC 3.1.2.15) (UBIQUITIN THIOLESTERASE 4) (UBIQUITIN-SPECIFIC PROCESSING PROTEASE 4) (DEUBIQUITINATING ENZYME 4) (UBIQUITOUS NUCLEAR PROTEIN HOMOLOG).//7.60E-28//86aa//47%//Q13107
    • BRAMY20045210
    • BRAMY20045420
    • BRAMY20047560
    • BRAMY20050640
    • BRAMY20050940
    • BRAMY20051820//Human mRNA for Doc2 (Double C2), complete cds.//1.90E-49//102aa//99%//D31897
    • BRAMY20052440
    • BRAMY20053910
    • BRAMY20055760//POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE VA (EC 3.6.1.-).//5.80E-130//393aa//59%//054827
    • BRAMY20056620//Homo sapiens mccb mRNA for non-biotin containing subunit of 3-methylcrotonyl-CoA carboxylase, complete cds.//3.00E-106//203aa//100%//AB050049
    • BRAMY20056840//UBE-1c2//2.40E-74//261aa//53%//AB030505
    • BRAMY20063750//Homo sapiens HRIHFB2007 mRNA, partial cds.//3.40E-139//253aa//99%//AB015330
    • BRAMY20072440
    • BRAMY20072870//ACETYL-COENZYME A SYNTHETASE (EC 6.2.1.1) (ACETATE-COA LIGASE) (ACYL-ACTIVATING ENZYME).//2.50E-15//88aa//46%//P16929
    • BRAMY20073080
    • BRAMY20074110
    • BRAMY20074860
    • BRAMY20076100//STEROIDOGENIC FACTOR 1 (STF-1) (SF-1) (STEROID HORMONE RECEPTOR AD4BP) (FUSHI TARAZU FACTOR HOMOLOG 1).//4.80E-66//132aa//94%//P50569
    • BRAMY20076130
    • BRAMY20076530
    • BRAMY20083330//SYNAPSIN I.//4.50E-05//155aa//29%//P17599
    • BRAMY20083820
    • BRAMY20089770//P2X PURINOCEPTOR 7 (ATP RECEPTOR) (P2×7) (PURINERGIC RECEPTOR) (P2Z RECEPTOR).//3.30E-136//242aa//99%//Q99572
    • BRAMY20091230//MITOCHONDRIAL UNCOUPLING PROTEIN 4 (UCP 4).//4.60E-121//224aa//100%//095847
    • BRAMY20093490//Mus musculus ubiquitin-protein ligase E3-alpha (Ubr1) mRNA, complete cds.//7.80E-43//139aa//55%//AF061555
    • BRAMY20094890//A KINASE ANCHOR PROTEIN 4 PRECURSOR (MAJOR FIBROUS SHEATH PROTEIN) (FSC1) (P82).//4.60E-06//131aa//27%//Q60662
    • BRAMY20095080
    • BRAMY20095570
    • BRAMY20096930//Torpedo marmorata mRNA for male sterility protein 2-like protein (ms21 gene).//2.00E-63//139aa//82%//AJ272073
    • BRAMY20100680
    • BRAMY20102900//Homo sapiens RU1 (RU1) mRNA, complete cds.//1.20E-47//151aa//58%//AF168132
    • BRAMY20107980
    • BRAMY20111780//ZINC FINGER PROTEIN 135.//1.00E-139//416aa//57%//P52742
    • BRAMY20117670//Mus musculus mmDNAJA4 mRNA for mmDj4, complete cds.//3.20E-118//239aa//90%//AB032401
    • BRAMY20118410
    • BRAMY20118490//GLYCEROL KINASE 2 (EC 2.7.1.30) (ATP:GLYCEROL 3-PHOSPHOTRANSFERASE 2) (GLYCEROKINASE 2) (GK 2).//1.80E-48//247aa//40%//Q9X1E4
    • BRAMY20120170
    • BRAMY20123400
    • BRAMY20124970
    • BRAMY20125170
    • BRAMY20125360//L-ASPARAGINASE (EC 3.5.1.1) (L-ASPARAGINE AMIDOHYDROLASE).//3.30E-53//148aa//43%//Q9ZSD6
    • BRAMY20125550//Homo sapiens mRNA for 28 kD interferon responsive protein (IFRG28 gene).//4.40E-16//155aa//33%//AJ251832
    • BRAMY20126910
    • BRAMY20127310
    • BRAMY20127760
    • BRAMY20134050//NUCLEOSOME ASSEMBLY PROTEIN 1-LIKE 2 (BRAIN-SPECIFIC PROTEIN, X-LINKED).//1.40E-25//109aa//56%//P51860
    • BRAMY20135720
    • BRAMY20137360//Homo sapiens gene for TU12B1-TY, exon 12 and complete cds.//2.10E-18//257aa//31%//AB032786
    • BRAMY20139440
    • BRAMY20139750
    • BRAMY20143870//PEPTIDYL-TRNA HYDROLASE (EC 3.1.1.29) (PTH).//5.80E-27//182aa//35%//P96386
    • BRAMY20152510//PROTEIN-TYROSINE PHOSPHATASE STRIATUM-ENRICHED (EC 3.1.3.48) (STEP) (NEURAL-SPECIFIC PROTEIN-TYROSINE PHOSPHATASE) (FRAGMENT).//4.80E-293//537aa//97%//P54829
    • BRAMY20155500
    • BRAMY20158550//CALMODULIN.//1.60E-15//116aa//42%//P04352
    • BRAMY20159250
    • BRAMY20160020
    • BRAMY20173480
    • BRAMY20190550//EPIDERMAL GROWTH FACTOR RECEPTOR SUBSTRATE SUBSTRATE 15 (PROTEIN EPS15) (AF-1P PROTEIN).//2.20E-226//464aa//89%//P42566
    • BRAMY20194680
    • BRAMY20204270
    • BRAMY20206340//GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT-LIKE PROTEIN.//4.20E-07//151aa//27%//P38011
    • BRAMY20219620
    • BRAMY20221600//H. sapiens mRNA for novel T-cell activation protein.//1.60E-130//245aa//99%//X94232
    • BRAMY20223010//Mus musculus leucine-rich glioma-inactivated 1 protein precursor, (Lgi1) mRNA, complete cds.//2.00E-79//269aa//52%//AF246818
    • BRAMY20225250
    • BRAMY20225320
    • BRAMY20227230
    • BRAMY20227860//Homo sapiens dickkopf-3 (DKK-3) mRNA, complete cds.//2.30E-69//147aa//92%//AF177396
    • BRAMY20227960
    • BRAMY20231150//PUTATIVE ACID PHOSPHATASE F26C11.1 (EC 3.1.3.2).//2.30E-55//322aa//39%//Q09549
    • BRAMY20234820//Homo sapiens mitotic checkpoint protein (MAD1) mRNA, complete cds.//1.30E-286//561aa//100%//AF123318
    • BRAMY20237190
    • BRAMY20238630//TETRATRICOPEPTIDE REPEAT PROTEIN 4.//1.20E-147//276aa//99%//095801
    • BRAMY20243120
    • BRAMY20244490//ADENYLATE KINASE ISOENZYME 1 (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) (AK1) (MYOKINASE).//2.50E-19//119aa//37%//P00571
    • BRAMY20245140//Rattus norvegicus potassium channel (erg2) mRNA, complete cds.//1.00E-178//427aa//81%//AF016192
    • BRAMY20245350
    • BRAMY20245760//Araneus diadematus fibroin-4 mRNA, partial cds.//7.90E-05//285aa//22%//U47856
    • BRAMY20251210//EPHRIN TYPE-A RECEPTOR 7 PRECURSOR (EC 2.7.1.112) (TYROSINE-PROTEIN KINASE RECEPTOR EHK-3) (EPH HOMOLOGY KINASE-3) (EMBRYONIC BRAIN KINASE) (EBK) (DEVELOPMENTAL KINASE 1) (MDK-1).//3.80E-94//268aa//66%//Q61772
    • BRAMY20251750//Homo sapiens BRI3 mRNA, complete cds.//2.80E-131//242aa//95%//AF272043
    • BRAMY20263000//DYSTROPHIA MYOTONICA-CONTAINING WD REPEAT MOTIF PROTEIN (DMR-N9 PROTEIN).//2.60E-134//430aa//59%//Q08274
    • BRAMY20267780
    • BRAMY20269040
    • BRAMY20271140
    • BRAMY20274510//60S RIBOSOMAL PROTEIN L12.//1.10E-39//102aa//82%//P30050
    • BRAMY20285650
    • BRAMY20287400
    • BRAWH20014590//ZAKI-4 PROTEIN.//3.10E-92//187aa//93%//Q14206
    • BRAWH20020470
    • BRAWH20020600
    • BRAWH20021910//FATTY ACYL-COA HYDROLASE PRECURSOR, MEDIUM CHAIN (EC 3.1.2.14) (THIOESTERASE B).//1.30E-111//450aa//49%//Q04791
    • BRAWH20025490
    • BRAWH20026010//AD021 protein [Homo sapiens]//4.00E-55//245aa//44%//NP—057697
    • BRAWH20027250
    • BRAWH20030000
    • BRAWH20039640//SLIT PROTEIN PRECURSOR.//6.10E-19//282aa//31%//P24014
    • BRAWH20040680//PUTATIVE TRANSCRIPTION ELONGATION FACTOR S-II (TFIIS).//5.90E-06//179aa//29%//P52652
    • BRAWH20047790
    • BRAWH20050740//ZINC FINGER PROTEIN 151 (POLYOMAVIRUS LATE INITIATOR PROMOTER BINDING PROTEIN) (LP-1) (ZINC FINGER PROTEIN Z13).//1.60E-16//235aa//30%//Q60821
    • BRAWH20055240
    • BRAWH20055330
    • BRAWH20055780
    • BRAWH20058120
    • BRAWH20063010//SPLICEOSOME ASSOCIATED PROTEIN 49 (SAP 49) (SF3B53).//2.60E-06//121aa//33%//Q15427
    • BRAWH20078080
    • BRAWH20078620
    • BRAWH20080580//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//1.00E-116//316aa//63%//P51523
    • BRAWH20082550
    • BRAWH20082920//Human TFIIIC Box B-binding subunit mRNA, complete cds.//1.90E-36//72aa//100%//U02619
    • BRAWH20093040//PROTEIN KINASE CLK2 (EC 2.7.1.-).//2.70E-86//162aa//96%//P49760 BRAWH20093070//SYNAPSIN.//4.80E-06//245aa//28%//Q24546
    • BRAWH20094900//Mus musculus mRNA for sialidase, complete cds.//5.70E-73//310aa//50%//AB026842
    • BRAWH20095900//ZINC FINGER PROTEIN 184 (FRAGMENT).//1.20E-170//631aa//48%//Q99676 BRAWH20173790
    • BRAWH20174330//SPLICEOSOME ASSOCIATED PROTEIN 49 (SAP 49) (SF3B53).//4.50E-06//121aa//33%//Q15427
    • BRAWH20175230
    • BRAWH20175340
    • BRAWH20176850//Mus musculus mRNA for nuclear protein ZAP, complete cds.//9.50E-151//619aa//53%//AB033168
    • BRAWH20182670
    • BRAWH20183170//GRR1 PROTEIN.//9.30E-13//218aa//28%//P24814
    • BRAWH20185260
    • BRAWH20185270
    • BRAWH20186010
    • BRAWH20188750//BIOTIN SYNTHESIS PROTEIN BIOC.//5.80E-11//190aa//27%//P36571
    • BRAWH20190530//Homo sapiens BNPI mRNA for brain-specific Na-dependent inorganic phosphate cotransporter, complete cds.//2.10E-109//118aa//100%//AB032436
    • BRAWH20190550//PUTATIVE SERINE/THREONINE-PROTEIN KINASE PKWA (EC 2.7.1.-).//1.30E-05//172aa//29%//P49695
    • BRAWH20191980//PROLINE OXIDASE, MITOCHONDRIAL PRECURSOR (EC 1.5.3.-) (PROLINE DEHYDROGENASE).//2.10E-125//234aa//99%//043272
    • BRCAN10000760//UREA TRANSPORTER, ERYTHROCYTE.//1.30E-212//389aa//100%//Q13336
    • BRCAN10001050//PEANUT-LIKE PROTEIN 2 (BRAIN PROTEIN H5).//1.40E-62//122aa//98%//043236
    • BRCAN10001680
    • BRCAN20001480
    • BRCAN20004180//alpha-1C-adrenergic receptor splice form 2—human//1.10E-22//76aa//76%//S65657
    • BRCAN20005230//HEPARIN SULFATE N-DEACETYLASE/N-SULFOTRANSFERASE (EC 2.8.2.-) (N-HSST) (N-HEPARIN SULFATE SULFOTRANSFERASE) (GLUCOSAMINYL N-DEACETYLASE/N-SULFOTRANSFERASE).//8.90E-15//168aa//28%//P52849
    • BRCAN20005410//Human 1(3)mbt protein homolog mRNA, complete cds.//2.00E-95//378aa//50%//U89358
    • BRCOC10000400
    • BRCOC20000470//Homo sapiens DEME-6 mRNA, partial cds.//7.30E-37//252aa//28%//AF007170
    • BRCOC20003600//VACUOLAR ATP SYNTHASE SUBUNIT AC45 PRECURSOR (EC 3.6.1.34) (V-ATPASE AC45 SUBUNIT).//5.90E-192//418aa//85%//P40682
    • BRHIP10000720
    • BRHIP10001040//tweety homolog 1 (Drosophila) [Mus musculus]//1.30E-68//311aa//44%//NP—067299
    • BRHIP20000210
    • BRHIP20003590
    • BRHIP20005060
    • BRSSN20001970
    • BRSSN20005610//Mus musculus semaphorin cytoplasmic domain-associated protein 3A (Semcap3) mRNA, complete cds.//6.30E-225//730aa//60%//AF127084
    • BRSSN20005660
    • BRSSN20066440//ZINC FINGER PROTEIN 202.//3.60E-37//169aa//37%//095125
    • BRSSN20074640//HYPOTHETICAL 35.8 KDA PROTEIN IN PRP16—SRP40 INTERGENIC REGION.//4.50E-20//217aa//28%//P36163
    • BRSSN20091190
    • BRSSN20092440
    • BRSSN20093890//Homo sapiens mRNA for Kelch motif containing protein, complete cds.//8.40E-13//203aa//30%//AB026190
    • CD34C20001750//MHC CLASS INK CELL RECEPTOR PRECURSOR (NATURAL KILLER ASSOCIATED TRANSCRIPT 4) (NKAT-4).//1.10E-18//214aa//35%//P43630
    • CTONG10000090
    • CTONG20000340
    • CTONG20002790
    • CTONG20004110//Mus musculus ankycorbin mRNA, complete cds.//6.20E-55//1006aa//24%//AF202315
    • CTONG20004520//development- and differentiation-enhancing factor 2; PYK2 C terminus-associated protein [Homo sapiens].//2.00E-86//310aa//81%//NP—003878
    • CTONG20007660//Rattus norvegicus caspase recruitment domain protein 9 mRNA, complete cds.//7.30E-28//319aa//32%//AF311288
    • CTONG20008190//YPT1-RELATED PROTEIN 2.//3.00E-30//160aa//40%//P17609
    • CTONG20008460
    • CTONG20015240
    • CTONG20017490//SEMAPHORIN 4A PRECURSOR (SEMAPHORIN B) (SEMA B).//3.10E-273//607aa//82%//Q62178
    • CTONG20020660
    • CTONG20020950//ZINC FINGER PROTEIN 37 (ZFP-37) (MALE GERM CELL SPECIFIC ZINC FINGER PROTEIN).//7.40E-23//258aa//25%//P17141
    • CTONG20027660
    • CTONG20029030//Homo sapiens Ras-binding protein SUR-8 mRNA, complete cds.//8.30E-25//402aa//28%//AF068920
    • CTONG20030280//VEGETATIBLE INCOMPATIBILITY PROTEIN HET-E-1.//2.90E-12//303aa//25%//Q00808
    • CTONG20031150
    • CTONG20031890
    • CTONG20032930//microtubule associated-protein orbit [Drosophila melanogaster]//1.00E-79//913aa//30%//BAA94248
    • CTONG20033500
    • CTONG20033610//Rattus norvegicus SNIP-a mRNA, complete cds.//2.50E-145//567aa//41%//AF156981
    • CTONG20033750//Drosophila melanogaster AAA family protein Bor (bor) mRNA, complete cds.//1.40E-174//492aa//66%//AF227209
    • CTONG20035240
    • CTONG20036800
    • CTONG20036990//BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN PRECURSOR (HSPG) (PERLECAN) (PLC).//1.10E-10//247aa//27%//Q05793
    • CTONG20039370
    • CTONG20041150//Streptomyces ansochromogenes strain 7100 SanE (sanE) gene, complete cds.//5.20E-05//133aa//35%//AF228524
    • CTONG20041260//Mus musculus retinoic acid-responsive protein (Stra6) mRNA, complete cds.//1.30E-238//602aa//74%//AF062476
    • CTONG20042640//NEUROBLAST DIFFERENTIATION ASSOCIATED PROTEIN AHNAK (DESMOYOKIN) (FRAGMENTS).//0//797aa//73%//Q09666
    • CTONG20044230//Mus musculus zinc finger protein (Mtsh1) mRNA, partial cds.//1.40E-289//601aa//89%//AF191309
    • CTONG20044870
    • CTONG20045500//ANION EXCHANGE PROTEIN 3 (CARDIAC/BRAIN BAND 3-LIKE PROTEIN) (CAE3/BAE3).//2.00E-19//276aa//30%//P48751
    • CTONG20046690
    • CTONG20049480
    • CTONG20050490
    • CTONG20051100//PUTATIVE METHYLTRANSFERASE (EC 2.1.1.-).//3.50E-29//72aa//87%//043709
    • CTONG20051450//testis development protein PRTD [Homo sapiens].//9.00E-50//140aa//85%//AAG33852
    • CTONG20052780//Homo sapiens mRNA for SH3 binding protein, complete cds.//8.00E-21//125aa//42%//AB005047
    • CTONG20053990//ZINC FINGER PROTEIN 195.//4.30E-08//40aa//75%//014628
    • CTONG20055670
    • CTONG20055850//Rattus norvegicus golgi peripheral membrane protein p65 (GRASP65) mRNA, complete cds.//1.10E-99//248aa//78%//AF015264
    • CTONG20056150
    • CTONG20057750
    • CTONG20057950
    • CTONG20059130//Mus musculus prominin-like protein mRNA, partial cds.//7.50E-103//259aa//77%//AF128113
    • CTONG20060040
    • CTONG20061290
    • CTONG20062730
    • CTONG20063770//M-PHASE PHOSPHOPROTEIN 9 (FRAGMENT).//1.80E-96//184aa//100%//Q99550
    • CTONG20063930//BETA-CHIMAERIN (BETA-CHIMERIN).//3.50E-31//189aa//34%//Q03070
    • CTONG20065240
    • CTONG20065680
    • CTONG20066110//Homo sapiens DEME-6 mRNA, partial cds.//8.70E-164//557aa//53%//AF007170
    • CTONG20068360//MITOCHONDRIAL CARNITINE/ACYLCARNITINE CARRIER PROTEIN (CARNITINE/ACYLCARNITINE TRANSLOCASE) (CAC).//8.00E-30//248aa//35%//P97521
    • CTONG20069320
    • CTONG20069420
    • CTONG20070090
    • CTONG20070720//N-CHIMAERIN (NC) (N-CHIMERIN) (ALPHA CHIMERIN) (A-CHIMAERIN).//9.20E-25//180aa//33%//P30337
    • CTONG20070780//SPERM-SPECIFIC ANTIGEN 2 (CLEAVAGE SIGNAL-1 PROTEIN) (CS-1).//1.90E-122//249aa//97%//P28290
    • CTONG20070910//Homo sapiens mRNA for 26S proteasome subunit p55, complete cds.//7.70E-227//400aa//100%//AB003103
    • CTONG20071040//BETA CRYSTALLIN B2 (BP).//6.80E-25//195aa//34%//P26775
    • CTONG20071680//HYPOTHETICAL 33.6 KDA PROTEIN IN TDK-PRFA INTERGENIC REGION.//7.40E-14//328aa//23%//P45869
    • CTONG20072930//ZINC FINGER PROTEIN 41 (FRAGMENT).//4.10E-216//542aa//69%//P51814
    • CTONG20073990
    • CTONG20074000//Mus musculus teashirt 2 (Tsh2) gene, partial cds.//0//1024aa//89%//AF207880
    • CTONG20074170
    • CTONG20074740
    • CTONG20076230
    • CTONG20076810//site-1 protease of sterol regulatory element binding proteins [Cricetulus griseus]//2.80E-245//463aa//93%//AF078105
    • CTONG20077760//SYNAPSIN I.//1.70E-08//209aa//32%//P17599
    • CTONG20078340//SUPPRESSOR PROTEIN SRP40.//4.10E-08//282aa//26%//P32583
    • CTONG20079590//ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE (EC 2.4.99.-) (ST6GALNACIII) (STY).//1.80E-151//305aa//85%//Q64686
    • CTONG20080140//HYPOTHETICAL 60.3 KDA PROTEIN R13G10.2 IN CHROMOSOME III.//8.40E-29//179aa//40%//Q21988
    • CTONG20081840
    • CTONG20083430
    • CTONG20083980//VASODILATOR-STIMULATED PHOSPHOPROTEIN (VASP).//4.50E-10//113aa//34%//P50552
    • CTONG20084020
    • CTONG20084660//ZINC FINGER PROTEIN 165.//3.30E-33//142aa//57%//P49910
    • CTONG20085210//MONO- AND DIACYLGLYCEROL LIPASE PRECURSOR (EC 3.1.1.-) (MDGL).//3.60E-06//94aa//34%//P25234
    • CTONG20133720
    • CTONG20165590
    • CTONG20165750//SON PROTEIN (SON3).//4.40E-239//427aa//99%//P18583
    • CTONG20166580
    • CTONG20167750
    • CTONG20168240
    • CTONG20168460
    • CTONG20169040//KERATIN, TYPE I CYTOSKELETAL 15 (CYTOKERATIN 15) (K15) (CK 15).//6.00E-112//223aa//99%//P19012
    • CTONG20169530
    • CTONG20170940//MYOTROPHIN (V-1 PROTEIN) (GRANULE CELL DIFFERENTIATION PROTEIN).//4.60E-10//93aa//36%//P80144
    • CTONG20174290//TRICHOHYALIN.//1.30E-07//340aa//21%//P37709
    • CTONG20174440
    • CTONG20174580//Homo sapiens mRNA for vascular Rab-GAP/TBC-containing protein complete cds.//1.00E-115//335aa//61%//NP—008994
    • CTONG20176040//ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 3 (ARD3).//1.70E-34//155aa//43%//P37996
    • CTONG20179390
    • CTONG20179890
    • CTONG20179980
    • CTONG20180620
    • CTONG20180690
    • CTONG20181350
    • CTONG20183430//ANKYRIN 2 (BRAIN ANKYRIN) (ANKYRIN B) (ANKYRIN, NONERYTHROID).//4.60E-30//311aa//32%//Q01484
    • CTONG20183830//IRLB [Homo sapiens]//1.50E-104//191aa//100%//CAA45013
    • CTONG20184130
    • CTONG20184830//ATP-BINDING CASSETTE, SUB-FAMILY A, MEMBER 1 (ATP-BINDING CASSETTE TRANSPORTER 1) (ATP-BINDING CASSETTE 1).//1.30E-63//271aa//47%//P41233
    • CTONG20186140
    • CTONG20186290//ALDEHYDE DEHYDROGENASE, DIMERIC NADP-PREFERRING (EC 1.2.1.5) (ALDH CLASS 3).//1.50E-74//144aa//100%//P30838
    • CTONG20186370//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//2.60E-52//324aa//33%//P51523
    • CTONG20186520//ZINC FINGER PROTEIN MFG-3.//1.40E-197//643aa//53%//P16374
    • CTONG20186550//cca3 protein—rat//2.10E-37//141aa//56%//T31081
    • CTONG20188080
    • CTONG20189000//PROBABLE GUANINE NUCLEOTIDE REGULATORY PROTEIN TIM (ONCOGENE TIM) (P60 TIM) (TRANSFORMING IMMORTALIZED MAMMARY ONCOGENE).//1.10E-48//222aa//50%//Q12774
    • CTONG20190290//39.1 KDA PROTEIN IN SURE-CYSC INTERGENIC REGION.//6.00E-15//132aa//31%//Q57261
    • CTONG20190630
    • DFNES20016470//Homo sapiens SDP1 protein mRNA, complete cds.//4.90E-33//95aa//37%//AF076957
    • DFNES20018000//CADHERIN-RELATED TUMOR SUPPRESSOR PRECURSOR (FAT PROTEIN).//8.70E-23//306aa//30%//P33450
    • DFNES20025500//Homo sapiens mRNA for paraplegin-like protein.//3.00E-29//68aa//94%//Y18314
    • DFNES20028170//Mouse mRNA for RNA polymerase I associated factor (PAF53), complete cds.//1.40E-165//393aa//78%//D14336
    • DFNES20029660
    • DFNES20032550
    • DFNES20043710
    • DFNES20046840//FORKHEAD BOX PROTEIN E1 (FORKHEAD-RELATED PROTEIN FKHL15) (THYROID TRANSCRIPTION FACTOR 2) (TTF-2).//6.20E-05//151aa//32%//000358
    • DFNES20055400//Homo sapiens diphthamide biosynthesis protein-2 (DPH2) mRNA, complete cds.//5.40E-203//413aa//91%//AF053003
    • DFNES20057660//GRAVE'S DISEASE CARRIER PROTEIN (GDC) (MITOCHONDRIAL SOLUTE CARRIER PROTEIN HOMOLOG).//7.00E-31//247aa//33%//Q01888
    • DFNES20063460//PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN3 (EC 3.1.13.4) (PAB1P-DEPENDENT POLY(A)-NUCLEASE).//1.90E-23//115aa//43%//P36102
    • DFNES20072990//HYPOTHETICAL 46.7 KDA PROTEIN IN HOR7-COX7 INTERGENIC REGION.//1.80E-22//310aa//25%//Q04835
    • DFNES20073320//Mus musculus RING-finger protein MURF mRNA, complete cds.//6.70E-118//362aa//61%//AF294790
    • DFNES20076340
    • DFNES20080880//POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE (EC 2.4.1.41) (PROTEIN-UDP ACETYLGALACTOSAMINYLTRANSFERASE) (UDP-GALNAC:POLYPEPTIDE, N-ACETYLGALACTOSAMINYLTRANSFERASE) (GALNAC-T1).//2.00E-104//486aa//43%//Q10472
    • DFNES20088810
    • DFNES20094820//coronin-like protein [Schizosaccharomyces pombe]//3.60E-20//333aa//24%//CAB11184
    • FCBBF10000230//H. sapiens mRNA from TYL gene.//3.30E-155//650aa//51%//X99688
    • FCBBF10002200
    • FCBBF10004760//Homo sapiens GAP-like protein (N61) mRNA, complete cds.//9.10E-82//412aa//44%//AF251038
    • FCBBF20018680//RABPHILIN-3A.//1.70E-16//262aa//30%//P47709
    • FCBBF20020440
    • FCBBF20021110
    • FCBBF20023490//PUTATIVE PRE-mRNA SPLICING FACTOR ATP-DEPENDENT RNA HELICASE SPAC10F6.02C.//1.20E-90//505aa//39%//042643
    • FCBBF20028980
    • FCBBF20029280
    • FCBBF20032930
    • FCBBF20033360//RING CANAL PROTEIN (KELCH PROTEIN).//7.40E-33//234aa//32%//Q04652
    • FCBBF20035430//Mus musculus arsenite inducible RNA associated protein (Airap) mRNA, complete cds.//1.50E-51//152aa//57%//AF224494
    • FCBBF20035490//GAP-associated tyrosine phosphoprotein p62 (Sam68) [Homo sapiens]>pir∥A38219 GAP-associated tyrosine phosphoprotein p62//1.50E-214//415aa//93%//NP—006550
    • FCBBF20036360
    • FCBBF20038230
    • FCBBF20038950
    • FCBBF20041380
    • FCBBF20043730
    • FCBBF20054390
    • FCBBF20056580//Mus musculus NSD1 protein mRNA, complete cds.//3.40E-304//773aa//75%//AF064553
    • FCBBF20059660
    • FCBBF20061310
    • FCBBF20066340//Homo sapiens nuclear dual-specificity phosphatase (SBF1) mRNA, partial cds.//1.20E-68//312aa//49%//U93181
    • FCBBF20070800
    • FCBBF20070950//MICRONUCLEAR LINKER HISTONE POLYPROTEIN (MIC LH) [CONTAINS: LINKER HISTONE PROTEINS ALPHA, BETA, DELTA AND GAMMA].//5.00E-10//601aa//20%//P40631
    • FCBBF30000010
    • FCBBF30001020
    • FCBBF30001100//CRAG protein [Drosophila melanogaster]//7.40E-185//800aa//46%//CAA76938
    • FCBBF30001150
    • FCBBF30002270//HISTONE H1′ (H1.0) (H1(0)).//4.90E-62//154aa//84%//P07305
    • FCBBF30002280//THIOREDOXIN PEROXIDASE 2 (THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE 2) (PROLIFERATION-ASSOCIATED PROTEIN PAG) (NATURAL KILLER CELL ENHANCING FACTOR A) (NKEF-A).//1.20E-27//61aa//98%//Q06830
    • FCBBF30002330
    • FCBBF30003610//ZINC FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10) (HPF7).//9.10E-93//313aa//53%//Q05481
    • FCBBF30004340//Homo sapiens GalNAc-T9 mRNA for UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, complete cds.//1.60E-109//299aa//63%//AB040672
    • FCBBF30004730
    • FCBBF30005180
    • FCBBF30005360//Mus musculus spermatogenesis associated factor (SPAF) mRNA, complete cds.//0//894aa//84%//AF049099
    • FCBBF30005500//HYPOTHETICAL PROTEIN KIAA0167.//5.80E-16//124aa//36%//Q99490
    • FCBBF30019140//CHROMODOMAIN HELICASE-DNA-BINDING PROTEIN 3 (CHD-3) (MI-2 AUTOANTIGEN 240 KDA PROTEIN) (MI2-ALPHA).//0//725aa//82%//Q12873
    • FCBBF30019180//SERINE/THREONINE PROTEIN PHOSPHATASE 2A, 65 KDA REGULATORY SUBUNIT A, ALPHA ISOFORM (PP2A, SUBUNIT A, PR65-ALPHA ISOFORM) (PP2A, SUBUNIT A, R1-ALPHA ISOFORM).//4.60E-233//451aa//98%//P54612
    • FCBBF30019240
    • FCBBF30021900//ZINC FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10) (HPF7).//4.10E-161//633aa//48%//Q05481
    • FCBBF30022680//putative 5′-3′ exonuclease//9.00E-12//200aa//25%//AAG29662
    • FCBBF30026580//Homo sapiens retinoblastoma-associated protein RAP140 mRNA, complete cds.//7.60E-27//367aa//28%//AF180425
    • FCBBF30029250//GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3) (GLUCAN 1,4-ALPHA-GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN GLUCOHYDROLASE).//4.00E-18//754aa//23%//P08640
    • FCBBF30035570
    • FCBBF30042610//Homo sapiens CTL2 gene.//2.10E-137//393aa//60%//AJ245621
    • FCBBF30048420//TBX19 PROTEIN (T-BOX PROTEIN 19).//1.40E-94//212aa//85%//060806
    • FCBBF30053300//Human autoantigen pericentriol material 1 (PCM-1) mRNA, complete cds.//0//708aa//90%//L27841
    • FCBBF30056980
    • FCBBF30062490//Mus musculus prominin-like protein mRNA, partial cds.//7.70E-85//210aa//79%//AF128113
    • FCBBF30063990
    • FCBBF30068210
    • FCBBF30071500//Homo sapiens dentin phosphoryn mRNA, complete cds.//2.80E-09//675aa//22%//AF094508
    • FCBBF30072440//Homo sapiens SARDH mRNA, alternatively spliced, complete cds.//1.70E-14//81aa//53%//AF095737
    • FCBBF30072480
    • FCBBF30074530
    • FCBBF30074620
    • FCBBF30075970
    • FCBBF30076310//CAMP-DEPENDENT PROTEIN KINASE, BETA-CATALYTIC SUBUNIT (EC 2.7.1.37) (PKA C-BETA).//8.20E-166//240aa//100%//P22694
    • FCBBF30078600
    • FCBBF30079770
    • FCBBF30080730//SPLICING FACTOR, ARGININE/SERINE-RICH 7 (SPLICING FACTOR 9G8).//3.40E-70//136aa//95%//Q16629
    • FCBBF30081000
    • FCBBF30085560//HYPOTHETICAL 60.3 KDA PROTEIN R13G10.2 IN CHROMOSOME III.//1.10E-87//531aa//38%//Q21988
    • FCBBF30088700
    • FCBBF30089380
    • FCBBF30091010
    • FCBBF30091520//GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3) (GLUCAN 1,4-ALPHA-GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN GLUCOHYDROLASE).//3.70E-09//631aa//21%//P08640
    • FCBBF30093170//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//2.10E-63//173aa//65%//P51523
    • FCBBF30095410
    • FCBBF30099490
    • FCBBF30100080//ARF NUCLEOTIDE-BINDING SITE OPENER (ARNO PROTEIN) (ARF EXCHANGE FACTOR).//1.10E-57//108aa//100%//Q99418
    • FCBBF30100120//Mus musculus semaphorin cytoplasmic domain-associated protein 3A (Semcap3) mRNA, complete cds.//2.10E-192//769aa//50%//AF127084
    • FCBBF30100410//Mus musculus testis-specific Y-encoded-like protein (Tspyl1) mRNA, complete cds.//1.90E-56//324aa//42%//AF042180
    • FCBBF30101240
    • FCBBF30101300
    • FCBBF30105080
    • FCBBF30105440//Rattus norvegicus ion transporter protein (NRITP) mRNA, partial cds.//3.40E-36//82aa//91%//AF184921
    • FCBBF30105860//microtubule associated-protein orbit [Drosophila melanogaster].//1.00E-79//556aa//33%//BAA94248
    • FCBBF30106950
    • FCBBF30107290//MITOCHONDRIAL PROCESSING PEPTIDASE ALPHA SUBUNIT PRECURSOR (EC 3.4.24.64) (ALPHA-MPP) (P-55) (HA1523) (KIAA0123).//1.00E-91//172aa//100%//Q10713
    • FCBBF30107330
    • FCBBF30114180
    • FCBBF30114850//Homo sapiens C2H2 (Kruppel-type) zinc finger protein mRNA, complete cds.//3.20E-24//249aa//34%//AF159567
    • FCBBF30115230
    • FCBBF30115920//Homo sapiens nolp mRNA, complete cds.//9.40E-220//257aa//100%//AB017800
    • FCBBF30118670//Homo sapiens disintegrin and metalloproteinase domain 19 (ADAM19) mRNA, partial cds.//0//601aa//97%//AF134707
    • FCBBF30118890//Drosophila melanogaster La related protein (larp) mRNA, partial cds.//6.70E-25//221aa//35%//AF221108
    • FCBBF30125460
    • FCBBF30125880//Homo sapiens single-strand selective monofunctional uracil DNA glycosylase mRNA, complete cds.//6.40E-81//96aa//100%//AF125182
    • FCBBF30128420
    • FCBBF30129010//ZINC FINGER PROTEIN 36 (ZINC FINGER PROTEIN KOX18) (FRAGMENT).//1.20E-179//322aa//100%//P17029
    • FCBBF30130410//CALDESMON (CDM).//3.30E-06//170aa//32%//P12957
    • FCBBF30130580
    • FCBBF30132050//Homo sapiens mRNA for UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase.//2.10E-43//253aa//36%//Y15014 FCBBF30132660//Drosophila melanogaster Canton S tartan protein (trn) mRNA, complete cds.//2.00E-15//293aa//30%//U02078
    • FCBBF30135890//GLUTENIN, LOW MOLECULAR WEIGHT SUBUNIT PRECURSOR.//2.60E-07//163aa//34%//P10385
    • FCBBF30136230//NIL-2-A ZINC FINGER PROTEIN (NEGATIVE REGULATOR OF IL2) (TRANSCRIPTION FACTOR 8).//0//1090aa//94%//P37275
    • FCBBF30138000//trg protein—rat//1.30E-82//560aa//37%//160486
    • FCBBF30142290//dJ127B20.3 (novel PHD finger protein) [Homo sapiens].//1.00E-140//287aa//96%//CAB62994
    • FCBBF30143550//FYVE FINGER-CONTAINING PHOSPHOINOSITIDE KINASE (EC 2.7.1.68) (1-PHOSPHATIDYLINOSITOL-4-PHOSPHATE KINASE) (PIP5K) (PTDINS(4)P-5-KINASE) (P235).//0//1027aa//91%//Q9Z1T6
    • FCBBF30145670
    • FCBBF30151190
    • FCBBF30153170//6-PHOSPHOFRUCTOKINASE, LIVER TYPE (EC 2.7.1.11) (PHOSPHOFRUCTOKINASE 1) (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTO-1-KINASE ISOZYME B).//0//670aa//99%//P17858
    • FCBBF30157270//Rattus norvegicus PAPIN mRNA, complete cds.//1.20E-179//639aa//58%//AF169411
    • FCBBF30161780
    • FCBBF30164510//RETINAL-CADHERIN PRECURSOR(R-CADHERIN) (R-CAD).//0//794aa//98%//P55283
    • FCBBF30166220//SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC (EC 2.1.2.1) (SERINE METHYLASE) (GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT).//2.70E-12//33aa//100%//P34896
    • FCBBF30169280//Petunia x hybrida PGPD14 (PGPD14) mRNA, complete cds.//1.40E-62//261 aa//42%//AF049930
    • FCBBF30169870
    • FCBBF30170710
    • FCBBF30171230//NEUROENDOCRINE CONVERTASE 2 PRECURSOR (EC 3.4.21.94) (NEC 2) (PC2) (PROHORMONE CONVERTASE 2) (PROPROTEIN CONVERTASE 2) (KEX2-LIKE ENDOPROTEASE 2).//1.70E-82//181aa//86%//P16519
    • FCBBF30172330
    • FCBBF30173960//erythroid differentiation-related factor 1 [Homo sapiens].//6.00E-32//113aa//100%//AAC0001
    • FCBBF30175350//MITOGEN-ACTIVATED PROTEIN KINASE 7 (EC 2.7.1.-) (EXTRACELLULAR SIGNAL-REGULATED KINASE 5) (ERK5) (ERK4) (BMK1 KINASE).//4.60E-06//245aa//28%//Q13164
    • FCBBF30177290//HYPOTHETICAL 47.6 KDA PROTEIN C16C10.5 IN CHROMOSOME III.//2.40E-28//133aa//46%//Q09251
    • FCBBF30179180
    • FCBBF30179740
    • FCBBF30181730
    • FCBBF30194370
    • FCBBF30194550//ANKYRIN 1 (ERYTHROCYTE ANKYRIN) (ANKYRIN R) (ANKYRINS 2.1 AND 2.2).//9.90E-54//478aa//33%//P16157
    • FCBBF30195690//SYNAPTOTAGMIN I.//1.30E-27//138aa//31%//P34693
    • FCBBF30195700
    • FCBBF30197840//Mouse mRNA for seizure-related gene product 6 type 2 precursor, complete cds.//0//869aa//91%//D64009
    • FCBBF30198670//dof protein—fruit fly (Drosophila melanogaster)//6.60E-05//272aa//24%//T13712
    • FCBBF30201630//Chlamydomonas reinhardtii dhc1 gene for 1-alpha dynein heavy chain.//1.10E-121//384aa//58%//AJ243806
    • FCBBF30212210
    • FCBBF30215240//mitogen inducible gene mig-2—human//2.20E-135//263aa//96%//S69890
    • FCBBF30220050//OXYSTEROLS RECEPTOR LXR-BETA (LIVER X RECEPTOR BETA) (NUCLEAR ORPHAN RECEPTOR LXR-BETA) (UBIQUITOUSLY-EXPRESSED NUCLEAR RECEPTOR) (NUCLEAR RECEPTOR NER).//6.90E-96//167aa//100%//P55055
    • FCBBF30222910//Mus musculus Rap2 interacting protein 8 (RPIP8) mRNA, complete cds.//4.70E-29//76aa//46%//U73941
    • FCBBF30223110
    • FCBBF30223210//PLEXIN 4 PRECURSOR (TRANSMEMBRANE PROTEIN SEX).//1.70E-72//179aa//76%//P51805
    • FCBBF30225930
    • FCBBF30228940//Homo sapiens zinc finger protein dp mRNA, complete cds.//2.60E-14//114aa//42%//AF153201
    • FCBBF30230610
    • FCBBF30236670//Homo sapiens DEAD-box protein abstrakt (ABS) mRNA, complete cds.//1.00E-128//276aa//91%//AF195417
    • FCBBF30250980//GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT-LIKE PROTEIN.//3.20E-06//190aa//28%//024076
    • FCBBF30255680//Rattus norvegicus brain specific cortactin-binding protein CBP90 mRNA, partial cds.//1.80E-275//641aa//82%//AF053768
    • FCBBF30257370//CARNITINE DEFICIENCY-ASSOCIATED PROTEIN EXPRESSED IN VENTRICLE 1 (CDV-1 PROTEIN).//2.80E-169//355aa//92%//035594
    • FCBBF30259050//Mus musculus (clone pMLZ-1) zinc finger protein (Zfp) mRNA, 3′ end of cds.//1.40E-241//499aa//83%//L36315
    • FCBBF30260210//Drosophila melanogaster KISMET-L long isoform (kis) mRNA, complete cds.//3.90E-178//420aa//68%//AF215703
    • FCBBF30260480//Mus musculus putative E1-E2 ATPase mRNA, partial cds.//1.80E-78//154aa//95%//AF156547
    • FCBBF30263080//ZINC FINGER PROTEIN 83 (ZINC FINGER PROTEIN HPF1).//4.20E-33//107aa//58%//P51522 FCBBF30266510
    • FCBBF30271990//ANKYRIN 1 (ERYTHROCYTE ANKYRIN).//3.00E-43//419aa//33%//Q02357
    • FCBBF30275590//dedicator of cyto-kinesis 1 [Homo sapiens].//1.00E-138//791aa//37%//NP—001371
    • FCBBF30282020//cca3 protein—rat//5.50E-249//492aa//94%//T31081
    • FCBBF30285930//ZINC FINGER PROTEIN ZFP-1 (MKR1 PROTEIN).//5.70E-68//125aa//97%//P08042
    • FCBBF30287940
    • FCBBF40000610//late gestation lung 2 protein [Rattus norvegicus].//5.00E-86//178aa//94%//AAF44721
    • FCBBF40001920
    • FCBBF40005000
    • FCBBF50000410
    • FCBBF50000610
    • FCBBF50001650//Homo sapiens JP3 mRNA for junctophilin type3, complete cds.//1.20E-111//407aa//57%//AB042636
    • FCBBF50003530//H. sapiens mRNA for dinG gene.//2.70E-137//181aa//100%//Y10571
    • FCBBF50004950
    • FEBRA20005040//MYOSIN HEAVY CHAIN, STRIATED MUSCLE.//1.90E-13//479aa//23%//P24733
    • FEBRA20007820//MLN 64 PROTEIN (CAB1 PROTEIN).//7.00E-31//129aa//51%//Q14849
    • FEBRA20018670
    • FEBRA20026820//ZINC FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10) (HPF7).//2.20E-135//431aa//50%//Q05481
    • FEBRA20027070//ZINC FINGER PROTEIN 41 (FRAGMENT).//1.00E-139//333aa//70%//P51814
    • FEBRA20029620
    • FEBRA20031000//TRICHOHYALIN.//2.20E-16//360aa//26%//P37709
    • FEBRA20031150//Homo sapiens HSKM-B (HSKM-B) mRNA, complete cds.//2.00E-29//63aa//100%//AF226053
    • FEBRA20031280
    • FEBRA20031810
    • FEBRA20035200
    • FEBRA20035240//SPLICEOSOME ASSOCIATED PROTEIN 49 (SAP 49) (SF3B53).//7.30E-05//108aa//31%//Q15427
    • FEBRA20038220//GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3) (GLUCAN 1,4-ALPHA-GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN GLUCOHYDROLASE).//7.50E-05//256aa//24%//P08640
    • FEBRA20038330
    • FEBRA20038970//Homo sapiens mRNA for stabilin-1 (stab1 gene).//1.30E-42//413aa//99%//AJ275213
    • FEBRA20039070
    • FEBRA20039260//NonF [Streptomyces griseus subsp. griseus].//2.20E-16//140aa//38%//AAD37457
    • FEBRA20040230
    • FEBRA20040260
    • FEBRA20040290
    • FEBRA20040560//Homo sapiens delta-6 fatty acid desaturase (CYB5RP) mRNA, complete cds.//1.70E-112//204aa//100%//AF134404
    • FEBRA20045380//EVI-5 homolog [Homo sapiens].//7.00E-49//130aa//81%//AAC16031
    • FEBRA20046200//ANKYRIN 2 (BRAIN ANKYRIN) (ANKYRIN B) (ANKYRIN, NONERYTHROID).//1.70E-25//368aa//30%//Q01484
    • FEBRA20046280
    • FEBRA20046510//ZINC FINGER PROTEIN 135.//1.10E-94//260aa//62%//P52742
    • FEBRA20057010//ZINC FINGER PROTEIN 195.//1.30E-12//47aa//70%//014628
    • FEBRA20063720//ZINC FINGER PROTEIN 85 (ZINC FINGER PROTEIN HPF4) (HTF1).//3.10E-243//586aa//73%//Q03923
    • FEBRA20076200
    • FEBRA20078180
    • FEBRA20078800//NADH-UBIQUINONE OXIDOREDUCTASE 20 KDA SUBUNIT PRECURSOR (EC 1.6.5.3) (EC 1.6.99.3) (COMPLEX I-20 KD) (CI-20KD) (PSST SUBUNIT).//2.30E-96//192aa//96%//075251
    • FEBRA20080860
    • FEBRA20082660
    • FEBRA20083410
    • FEBRA20084750
    • FEBRA20086600
    • FEBRA20087550//damage-specific DNA binding protein 2 (48 kD) [Homo sapiens]//1.10E-106//119aa//94%//NP—000098
    • FEBRA20088610//CELLULAR RETINALDEHYDE-BINDING PROTEIN (CRALBP).//2.40E-14//145aa//30%//P10123
    • FEBRA20088810//FIBROBLAST GROWTH FACTOR-17 PRECURSOR (FGF-17).//1.00E-102//193aa//99%//060258
    • FEBRA20090160//MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 10 (EC 2.7.1.-) (MIXED LINEAGE KINASE 2) (PROTEIN KINASE MST).//1.10E-15//111aa//48%//Q02779
    • FEBRA20090220//TRANSLATION INITIATION FACTOR EIF-2B EPSILON SUBUNIT (EIF-2B GDP-GTP EXCHANGE FACTOR).//0//721aa//90%//P47823
    • FEBRA20091620
    • FEBRA20092760//PINCH PROTEIN (PARTICULARY INTERESTING NEW CYS-HIS PROTEIN).//2.50E-81//165aa//80%//P48059
    • FEBRA20093270
    • FEBRA20093280
    • FEBRA20095410
    • FEBRA20098040
    • FEBRA20099860//dynactin 3 (p22); dynactin light chain [Homo sapiens]//1.70E-41//89aa//100%//NP—009165
    • FEBRA20101410
    • FEBRA20108020
    • FEBRA20108580
    • FEBRA20115930
    • FEBRA20116650
    • FEBRA20121200
    • FEBRA20121950//X INACTIVE SPECIFIC TRANSCRIPT PROTEIN (FRAGMENT).//1.60E-07//155aa//24%//P27571
    • FEBRA20141980
    • FEBRA20150420//HYPOTHETICAL 131.5 KDA PROTEIN CO2F12.7 IN CHROMOSOME X.//6.90E-56//877aa//24%//Q11102
    • FEBRA20151750//Mus musculus (clone E5.53) Huntington disease (hdh) gene, exon 5.//2.60E-12//88aa//43%//L34024
    • FEBRA20163980
    • FEBRA20170240//ZINC FINGER PROTEIN 75.//7.90E-158//278aa//99%//P51815
    • FEBRA20172230//Mus musculus schwannoma-associated protein (SAM9) mRNA, complete cds.//1.70E-57//295aa//40%//AF026124
    • FEBRA20173330//PROTEIN KINASE CLK3 (EC 2.7.1.-).//4.80E-277//490aa//99%//P49761
    • FEBRA20175020
    • FEBRA20175330
    • FEBRA20177800//RNA binding motif protein 9 [Homo sapiens].//4.00E-09//75aa//95%//NP—055124
    • FEBRA20180510
    • FEBRA20182030
    • FEBRA20187460
    • FEBRA20191720//REGULATOR OF G-PROTEIN SIGNALING 11 (RGS11).//2.00E-73//104aa//100%//094810
    • HCHON10000150//SKELETAL MUSCLE LIM-PROTEIN 1 (SLIM 1) (SLIM) (FOUR AND A HALF LIM DOMAINS PROTEIN 1) (FHL-1).//4.10E-74//154aa//84%//Q13642
    • HCHON10001660
    • HCHON20000870//SERINE/THREONINE-PROTEIN KINASE CTR1 (EC 2.7.1.37).//2.10E-21//300aa//26%//Q05609
    • HCHON20002650//EARLY GROWTH RESPONSE PROTEIN 2 (EGR-2) (KROX-20 PROTEIN).//9.90E-05//166aa//26%//P51774
    • HCHON20002710//UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 13 (EC 3.1.2.15) (UBIQUITIN THIOLESTERASE 13) (UBIQUITIN-SPECIFIC PROCESSING PROTEASE 13) (DEUBIQUITINATING ENZYME 13).//7.40E-10//114aa//28%//P38187
    • HCHON20015050//LEUKOCYTE ADHESION GLYCOPROTEIN P150, 95 ALPHA CHAIN PRECURSOR (LEUKOCYTE ADHESION RECEPTOR P150, 95) (CD11C) (LEU M5) (INTEGRIN ALPHA-X).//8.60E-06//250aa//26%//P20702
    • HEART10001420//Mus musculus skm-BOP1 (Bop) mRNA, complete cds.//6.10E-259//485aa//94%//U76373
    • HEART10001490//ACTIN INTERACTING PROTEIN 2.//1.80E-71//243aa//58%//P46681
    • HEART20009590//Homo sapiens mRNA for paraplegin-like protein.//7.10E-47//145aa//67%//Y18314
    • HEART20019310//Mus musculus RING-finger protein MURF mRNA, complete cds.//6.70E-118//362aa//61%//AF294790
    • HEART20022200//METHIONINE AMINOPEPTIDASE 2 (EC 3.4.11.18) (METAP 2) (PEPTIDASE M 2) (INITIATION FACTOR 2 ASSOCIATED 67 KDA GLYCOPROTEIN) (P67).//1.50E-209//447aa//86%//P50579
    • HEART20031680
    • HEART20047640//CALCIUM/CALMODULIN-DEPENDENT 3′,5′-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1C (EC 3.1.4.17) (CAM-PDE 1C).//0//769aa//94%//Q63421
    • HEART20063100//H. sapiens mRNA histone RNA hairpin-binding protein.//5.60E-114//212aa//100%//Z71188
    • HEART20082570//AMINOMETHYLTRANSFERASE PRECURSOR (EC 2.1.2.10) (GLYCINE CLEAVAGE SYSTEM T PROTEIN).//5.50E-113//210aa//69%//P28337
    • HHDPC10001140
    • HHDPC20051850//STEROID RECEPTOR PROTEIN DG6.//9.50E-43//101aa//89%//015173
    • HHDPC20081230//NUCLEOLIN (PROTEIN C23).//0//681aa//92%//P19338
    • HHDPC20082790
    • HHDPC20082970
    • HHDPC20088160
    • HLUNG20008460//DIAPHANOUS PROTEIN HOMOLOG 2.//7.60E-33//521aa//26%//060879
    • HLUNG20009260
    • HLUNG20009550
    • HLUNG20010130
    • HLUNG20011260//TYROSINE-PROTEIN KINASE SRC-1 (EC 2.7.1.112) (P60-SRC-1).//1.10E-46//92aa//100%//P13115
    • HLUNG20011440
    • HLUNG20011460//Rattus norvegicus serine-arginine-rich splicing regulatory protein SRRP86 mRNA, complete cds.//1.20E-159//398aa//79%//AF234765
    • HLUNG20012140
    • HLUNG20014590//ZINC FINGER PROTEIN 135.//1.20E-122//350aa//59%//P52742
    • HLUNG20015070//SLIT PROTEIN PRECURSOR.//5.00E-14//167aa//33%//P24014
    • HLUNG20015180//BALBIANI RING PROTEIN 3 PRECURSOR.//8.80E-08//444aa//24%//Q03376
    • HLUNG20020500
    • HLUNG20020850//TLM PROTEIN (TLM ONCOGENE).//5.00E-17//91aa//54%//P17408
    • HLUNG20021450
    • HLUNG20023030
    • HLUNG20024050
    • HLUNG20025620
    • HLUNG20028110//zinc finger protein—fission yeast (Schizosaccharomyces pombe).//2.70E-23//140aa//38%//T39456
    • HLUNG20029420
    • HLUNG20029490
    • HLUNG20030420//Mus musculus mRNA for MAIL, complete cds.//1.00E-164//728aa//68%//AB020974
    • HLUNG20030490//Ambystoma tigrinum RPE65 protein mRNA, complete cds.//1.70E-64//335aa//42%//AF047465
    • HLUNG20030610
    • HLUNG20031620
    • HLUNG20032460//LYSOSOMAL PRO-X CARBOXYPEPTIDASE PRECURSOR (EC 3.4.16.2) (PROLYLCARBOXYPEPTIDASE) (PRCP) (PROLINE CARBOXYPEPTIDASE) (ANGIOTENSINASE C) (LYSOSOMAL CARBOXYPEPTIDASE C).//8.60E-274//440aa//99%//P42785
    • HLUNG20033060//Homo sapiens GAP-like protein (N61) mRNA, complete cds.//1.20E-81//389aa//45%//AF251038
    • HLUNG20033310
    • HLUNG20033350
    • HLUNG20034970
    • HLUNG20037140
    • HLUNG20037160//RETROVIRUS-RELATED ENV POLYPROTEIN.//1.90E-131//439aa//54%//P10267
    • HLUNG20037780
    • HLUNG20038330
    • HLUNG20041540//GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3) (GLUCAN 1,4-ALPHA-GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN GLUCOHYDROLASE).//8.80E-08//286aa//24%//P08640
    • HLUNG20041590//ubiquitous tetratricopeptide containing protein RoXaN [Homo sapiens].//1.00E-158//737aa//42%//AAF05541
    • HLUNG20042730//CYTOCHROME P450 4A4 (EC 1.14.14.1) (CYPIVA4) (PROSTAGLANDIN OMEGA-HYDROXYLASE) (P450-P-2).//4.90E-126//442aa//49%//P10611
    • HLUNG20045340//MOB2 PROTEIN (MPS1 BINDER 2).//4.60E-27//135aa//37%//P43563
    • HLUNG20047070
    • HLUNG20050760
    • HLUNG20051330
    • HLUNG20052300//AIG1 PROTEIN.//3.00E-23//216aa//30%//P54120
    • HLUNG20054790//PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT (EC 2.7.1.137) (IB PI3-KINASE P101 SUBUNIT) (PTDINS-3-KINASE P101) (PI3K) (P101-P13K).//8.30E-22//292aa//25%//002696
    • HLUNG20055240
    • HLUNG20056560
    • HLUNG20057380
    • HLUNG20059240
    • HLUNG20060670
    • HLUNG20063700//H. sapiens PEBP2aC1 acute myeloid leukaemia mRNA.//3.60E-22//62aa//79%//Z35278
    • HLUNG20065700
    • HLUNG20065990//SYNTAXIN 4.//8.80E-127//267aa//96%//Q12846
    • HLUNG20067810
    • HLUNG20068120//NUCLEAR TRANSITION PROTEIN 2 (TP-2).//7.10E-06//86aa//38%//P11101
    • HLUNG20069350//CALCYPHOSINE.//1.80E-13//128aa//31%//Q13938
    • HLUNG20070410
    • HLUNG20072100//Gallus gallus Dach2 protein (Dach2) mRNA, complete cds.//1.40E-236//404aa//79%//AF198349
    • HLUNG20072190
    • HLUNG20072450
    • HLUNG20074330
    • HLUNG20079310
    • HLUNG20081390//DNAJ PROTEIN.//1.60E-17//98aa//47%//P35515
    • HLUNG20081530//NEUROFILAMENT TRIPLET H PROTEIN (200 KDA NEUROFILAMENT PROTEIN) (NF-H).//1.90E-09//220aa//25%//P12036
    • HLUNG20082350//Homo sapiens goodpasture antigen-binding protein (COL4A3BP) mRNA, complete cds.//0//399aa//93%//AF136450
    • HLUNG20083330//alpha1 (III) collagen [Homo sapiens]//5.40E-61//113aa//99%//CAA29886
    • HLUNG20083480//Chicken mRNA for TSC-22 variant, complete cds, clone SLFEST52.//9.00E-178//527aa//68%//D82364
    • HLUNG20083840
    • HLUNG20083960
    • HLUNG20084790//HYPOTHETICAL 65.2 KDA TRP-ASP REPEATS CONTAINING PROTEIN D2030.9 IN CHROMOSOME I.//5.50E-47//161aa//53%//P90794
    • HLUNG20085210//Homo sapiens intersectin 2 (SH3D1B) mRNA, complete cds.//9.60E-28//62aa//95%//AF248540
    • HLUNG20088750
    • HLUNG20092530
    • HLUNG20093030
    • HLUNG20094130
    • KIDNE20011600
    • KIDNE20016360//Rattus norvegicus potassium channel (erg2) mRNA, complete cds.//0//418aa//96%//AF016192
    • KIDNE20024380
    • KIDNE20027980
    • KIDNE20080690//PROBABLE AMINOTRANSFERASE T01B11.2 (EC 2.6.1.-).//5.80E-114//445aa//48%//P91408
    • KIDNE20081170//Homo sapiens microtubule-based motor (HsKIFC3) mRNA, complete cds.//6.20E-153//216aa//99%//AF004426
    • KIDNE20083150
    • KIDNE20083620//L-ASPARAGINASE (EC 3.5.1.1) (L-ASPARAGINE AMIDOHYDROLASE).//2.60E-53//148aa//43%//Q9ZSD6
    • KIDNE20084030
    • KIDNE20084040//PHOSPHOLIPASE D1 (EC 3.1.4.4) (PLD 1) (CHOLINE PHOSPHATASE 1) (PHOSPHATIDYLCHOLINE-HYDROLYZING PHOSPHOLIPASE D1).//3.30E-70//134aa//100%//Q13393
    • KIDNE20084730//Homo sapiens FH1/FH2 domain-containing protein FHOS (FHOS) mRNA, complete cds.//2.60E-148//599aa//52%//AF113615
    • KIDNE20084800
    • KIDNE20086490
    • KIDNE20086660
    • KIDNE20086970
    • KIDNE20087880
    • KIDNE20088240//atopy related autoantigen CALC [Homo sapiens].//1.00E-26//300aa//26%//CAA76830
    • KIDNE20089870//HISTONE ACETYLTRANSFERASE TYPE B SUBUNIT 2 (RETINOBLASTOMA BINDING PROTEIN P46) (RETINOBLASTOMA-BINDING PROTEIN 7).//4.30E-237//422aa//99%//Q16576
    • KIDNE20091090
    • KIDNE20094260
    • KIDNE20094670//Drosophila melanogaster AAA family protein Bor (bor) mRNA, complete cds.//2.10E-124//399aa//59%//AF227209
    • KIDNE20095530
    • KIDNE20133460//Homo sapiens mRNA for sperm protein.//3.40E-146//284aa//100%//X91879
    • KIDNE20133880
    • KIDNE20134130
    • KIDNE20134890//CENTROMERIC PROTEIN E (CENP-E PROTEIN).//7.70E-05//169aa//21%//Q02224
    • KIDNE20137310
    • KIDNE20138450
    • KIDNE20140870//zinc finger protein 106 [Mus musculus]//2.10E-288//822aa//67%//AF060246
    • KIDNE20141120
    • KIDNE20141700//40S RIBOSOMAL PROTEIN S4, X ISOFORM (SINGLE COPY ABUNDANT mRNA PROTEIN) (SCR10).//2.60E-72//153aa//89%//P12750
    • KIDNE20142680
    • KIDNE20142900//THROMBOMODULIN PRECURSOR (FETOMODULIN) (TM) (CD141 ANTIGEN).//1.80E-71//119aa//100%//P07204
    • KIDNE20143200
    • KIDNE20147170//acetylglutamate synthase—fission yeast (Schizosaccharomyces pombe)//8.40E-15//143aa//37%//T40666
    • KIDNE20148080
    • KIDNE20149780//NG28 [Mus musculus]//3.50E-66//367aa//44%//AAC97966
    • KIDNE20150730//REGULATOR OF MITOTIC SPINDLE ASSEMBLY 1 (RMSA-1).//2.40E-06//84aa//41%//P49646
    • KIDNE20152440//Homo sapiens mRNA for serin protease with IGF-binding motif, complete cds.//1.80E-181//388aa//93%//D87258
    • KIDNE20154330//Rattus norvegicus mRNA for multi PDZ domain protein.//0//763aa//87%//AJ001320
    • KIDNE20154830
    • KIDNE20155980
    • KIDNE20157100
    • KIDNE20160360//ARF NUCLEOTIDE-BINDING SITE OPENER (ARNO PROTEIN) (ARF EXCHANGE FACTOR).//7.10E-40//194aa//41%//Q99418
    • KIDNE20160960
    • KIDNE20163710
    • KIDNE20165390//Homo sapiens mRNA for beta-tubulin folding cofactor D.//0//709aa//94%//AJ006417
    • KIDNE20169180//UROMODULIN PRECURSOR (TAMM-HORSFALL URINARY GLYCOPROTEIN) (THP).//0//615aa//99%//P07911
    • KIDNE20170400
    • KIDNE20173150//Bos taurus mRNA for mitochondrial aralkyl acylCoA:amino acid N-acyltransferase.//2.90E-53//277aa//40%//AJ223301
    • KIDNE20173430//Homo sapiens PDZ domain containing-protein (PDZK1) mRNA, complete cds.//7.90E-28//150aa//34%//AF012281
    • KIDNE20176030
    • KIDNE20181670
    • KIDNE20182540
    • KIDNE20186170//UDP-GLUCURONOSYLTRANSFERASE 2B13 PRECURSOR, MICROSOMAL (EC 2.4.1.17) (UDPGT) (EGT10).//4.40E-38//214aa//39%//P36512
    • KIDNE20188630
    • KIDNE20189890//Homo sapiens mRNA for KARP-1-binding protein 2 (KAB2), complete cds.//6.00E-30//177aa//44%//AB022658
    • KIDNE20189960//TREHALASE PRECURSOR (EC 3.2.1.28) (ALPHA,ALPHA-TREHALASE) (ALPHA,ALPHA-TREHALOSE GLUCOHYDROLASE).//1.40E-224//421aa//97%//043280
    • KIDNE20191870
    • LIVER20006260//Mus musculus zinc finger protein ZFP113 mRNA, complete cds.//4.50E-183//385aa//85%//AF167320
    • LIVER20007690
    • LIVER20007750
    • LIVER20010510
    • LIVER20010760//Homo sapiens C-type lectin-like receptor-1 mRNA, complete cds.//3.10E-134//208aa//100%//AF200949
    • LIVER20010990//Rattus norvegicus mRNA for putative integral membrane transport protein (UST1r).//7.00E-52//196aa//54%//Y09945
    • LIVER20011640//Human proline rich calmodulin-dependent protein kinase mRNA, complete cds.//2.00E-116//221aa//97%//U23460
    • LIVER20013890
    • LIVER20026440//CYTOCHROME P450 4F3 (EC 1.14.13.30) (CYPIVF3) (LEUKOTRIENE-B4 OMEGA-HYDROXYLASE) (LEUKOTRIENE-B4 20-MONOOXYGENASE) (CYTOCHROME P450-LTB-OMEGA).//2.60E-136//295aa//84%//Q08477
    • LIVER20030650//WHITE PROTEIN.//7.20E-09//229aa//25%//Q05360
    • LIVER20032340
    • LIVER20038000//MITOCHONDRIAL CARNITINE/ACYLCARNITINE CARRIER PROTEIN (CARNITINE/ACYLCARNITINE TRANSLOCASE) (CAC).//9.40E-40//148aa//38%//P97521
    • LIVER20040740//RETINAL-BINDING PROTEIN (RALBP).//3.10E-60//337aa//37%//P49193
    • LIVER20055270//SELENIDE, WATER DIKINASE 2 (EC 2.7.9.3) (SELENOPHOSPHATE SYNTHETASE 2) (SELENIUM DONOR PROTEIN 2).//2.70E-204//376aa//97%//Q99611
    • MESAN20006200//ANNEXIN II (LIPOCORTIN II) (CALPACTIN I HEAVY CHAIN) (CHROMOBINDIN 8) (P36) (PROTEIN I) (PLACENTAL ANTICOAGULANT PROTEIN IV) (PAP-IV).//1.70E-84//174aa//95%//P07355
    • MESAN20007110
    • MESAN20008150
    • MESAN20008940
    • MESAN20009090//Homo sapiens CEGP1 protein (CEGP1), mRNA//1.10E-179//553aa//58%//NM—020974
    • MESAN20016270//ZINC FINGER PROTEIN 37A (ZINC FINGER PROTEIN KOX21) (FRAGMENT).//1.60E-141//242aa//100%//P17032
    • MESAN20021130//Human SH3 domain-containing proline-rich kinase (sprk) mRNA, complete cds.//8.20E-168//346aa//91%//U07747 MESAN20021220//INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN COMPLEX ACID LABILE CHAIN PRECURSOR (ALS).//7.40E-26//197aa//30%//002833
    • MESAN20021470//SPINDLIN (30000 MR METAPHASE COMPLEX) (SSEC P).//3.50E-123//229aa//98%//Q61142
    • MESAN20021860
    • MESAN20026870
    • MESAN20027240//Rho guanine nucleotide exchange factor (GEF) 10 [Homo sapiens].//1.00E-134//620aa//40%//NP—055444
    • MESAN20027900//COLLAGEN ALPHA 3(VI) CHAIN PRECURSOR//0//1001aa//98%//P12111
    • MESAN20029780
    • MESAN20030350//Mus musculus diaphanous-related formin (Dia2) mRNA, complete cds.//6.60E-301//669aa//84%//AF094519
    • MESAN20030370
    • MESAN20030390
    • MESAN20033220//ALDEHYDE DEHYDROGENASE 7 (EC 1.2.1.5).//1.60E-24//54aa//100%//P43353
    • MESAN20034440//39.1 KDA PROTEIN IN SURE-CYSC INTERGENIC REGION.//2.70E-07//117aa//31%//Q57261
    • MESAN20038520//DNA-DIRECTED RNA POLYMERASE III 128 KDA POLYPEPTIDE (EC 2.7.7.6) (RNA POLYMERASE III SUBUNIT 2).//0//831aa//70%//P25167
    • MESAN20041380
    • MESAN20045750
    • MESAN20056890//SPLICING FACTOR, ARGININE/SERINE-RICH 2 (SPLICING FACTOR SC35) (SC-35) (SPLICING COMPONENT, 35 KDA) (PR264 PROTEIN).//3.30E-12//97aa//48%//Q01130
    • MESAN20057240//DNA EXCISION REPAIR PROTEIN ERCC-1.//5.90E-120//195aa//98%//P07992
    • MESAN20058110//65 KDA FK506-BINDING PROTEIN PRECURSOR (EC 5.2.1.8) (FKBP65) (FKBPRP) (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) (IMMUNOPHILIN FKBP65).//8.00E-117//229aa//89%//Q61576
    • MESAN20059570//Rattus norvegicus mRNA for seven transmembrane receptor, complete cds.//1.00E-173//484aa//63%//BAA82518
    • MESAN20060220
    • MESAN20060430
    • MESAN20065990//Human protein serine/threonine kinase stk2 mRNA, complete cds.//2.40E-07//65aa//50%//L20321
    • MESAN20067430//TROPOMYOSIN, FIBROBLAST ISOFORM TM3.//1.80E-39//87aa//100%//P09494
    • MESAN20069530//LIM domain only 7 isoform c [Homo sapiens]//2.20E-286//545aa//99%//NP—056667
    • MESAN20084150//Mus musculus secretory carrier membrane protein 4 mRNA, complete cds.//2.20E-48//128aa//72%//AF224721
    • MESAN20085360
    • MESAN20089260
    • MESAN20090190//CEGP1 protein [Homo sapiens].//0//880aa//57%//NP—066025
    • MESAN20094180
    • MESAN20095220
    • MESAN20095800//PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 10 (EC 5.2.1.8) (PPIASE) (ROTAMASE) (CYCLOPHILIN-10).//1.60E-31//150aa//46%//P52017
    • NESOP20004520//LYMPHOCYTE-SPECIFIC PROTEIN LSP1 (PP52 PROTEIN) (52 KDA PHOSPHOPROTEIN) (LYMPHOCYTE-SPECIFIC ANTIGEN WP34).//3.40E-173//321aa//99%//P33241
    • NESOP20005040
    • NT2NE20018740
    • NT2NE20018890//Homo sapiens WD-repeat protein 6 (WDR6) mRNA, complete cds.//6.60E-184//257aa//99%//AF099100
    • NT2NE20021860//Lytechinus variegatus embryonic blastocoelar extracellular matrix protein precursor (ECM3) mRNA, complete cds.//9.00E-68//466aa//36%//AF287478
    • NT2NE20026200//TRANSKETOLASE (EC 2.2.1.1) (TK).//1.80E-160//310aa//99%//P29401
    • NT2NE20026510//basic protein, cytosolic—fruit fly (Drosophila melanogaster)//6.10E-35//202aa//41%//S47857
    • NT2NE20028700
    • NT2NE20033150
    • NT2NE20037050//U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35 KDA SUBUNIT RELATED-PROTEIN 2.//7.20E-08//109aa//38%//Q15696
    • NT2NE20038870//ZINC FINGER X-LINKED PROTEIN ZXDA (FRAGMENT).//5.90E-153//405aa//72%//P98168
    • NT2NE20039210
    • NT2NE20042550//ADENYLATE KINASE, CHLOROPLAST (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE).//7.80E-15//153aa//28%//P43188
    • NT2NE20045190
    • NT2NE20047870
    • NT2NE20053230
    • NT2NE20053950//ZINC FINGER PROTEIN 136.//6.40E-108//284aa//64%//P52737
    • NT2NE20059210
    • NT2NE20059680//Homo sapiens integrin cytoplasmic domain associated protein (Icap-1a) mRNA, complete cds.//1.80E-44//96aa//100%//AF012023
    • NT2NE20060750//ZINC FINGER PROTEIN ZFP-36 (FRAGMENT).//1.20E-69//198aa//68%//P16415
    • NT2NE20061030//ZINC FINGER PROTEIN 165.//3.00E-39//125aa//65%//P49910
    • NT2NE20062880
    • NT2NE20064780//A-AGGLUTININ ATTACHMENT SUBUNIT PRECURSOR.//4.10E-05//443aa//24%//P32323
    • NT2NE20066590
    • NT2NE20069580
    • NT2NE20070520
    • NT2NE20073650
    • NT2NE20077250//Homo sapiens cell cycle progression 2 protein (CPR2) mRNA, complete cds.//1.20E-173//349aa//94%//AF011792
    • NT2NE20077270
    • NT2NE20077860
    • NT2NE20079670//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//2.60E-98//345aa//47%//P51523
    • NT2NE20080770
    • NT2NE20082130
    • NT2NE20082600//Homo sapiens zinc finger protein dp mRNA, complete cds.//2.10E-19//163aa//42%//AF153201
    • NT2NE20086070
    • NT2NE20087270//Homo sapiens putative RNA binding protein mRNA, alternatively spliced, complete cds.//4.30E-14//221aa//29%//AF119121
    • NT2NE20087850//ANTER-SPECIFIC PROLINE-RICH PROTEIN APG (PROTEIN CEX) (FRAGMENT).//1.80E-08//75aa//40%//P40603
    • NT2NE20088030
    • NT2NE20092950
    • NT2NE20095230//Homo sapiens HSKM-B (HSKM-B) mRNA, complete cds.//1.40E-09//112aa//32%//AF226053
    • NT2NE20104000
    • NT2NE20107810
    • NT2NE20108420//KES1 PROTEIN.//4.70E-25//312aa//31%//P35844
    • NT2NE20111190//C-TERMINAL BINDING PROTEIN 2.//9.00E-54//137aa//84%//P56545
    • NT2NE20112210
    • NT2NE20114850
    • NT2NE20117580//NADH-UBIQUINONE OXIDOREDUCTASE 20 KDA SUBUNIT PRECURSOR (EC 1.6.5.3) (EC 1.6.99.3) (COMPLEX I-20 KD) (CI-20 KD) (PSST SUBUNIT).//1.20E-76//153aa//95%//075251
    • NT2NE20119980//TUMOR NECROSIS FACTOR, ALPHA-INDUCED PROTEIN 1, ENDOTHELIAL (B12 PROTEIN).//6.10E-48//135aa//74%//Q13829
    • NT2NE20123610
    • NT2NE20124570
    • NT2NE20126030
    • NT2NE20127900//Homo sapiens myo-inositol 1-phosphate synthase A1 (ISYNA1) mRNA, complete cds.//1.40E-269//465aa//99%//AF220530
    • NT2NE20140130//SEMAPHORIN 3B PRECURSOR (SEMAPHORIN V) (SEMA V).//1.90E-42//90aa//100%//Q13214
    • NT2NE20140280
    • NT2NE20141040//DOWN SYNDROME CRITICAL REGION PROTEIN 1.//1.80E-105//197aa//99%//P53805
    • NT2NE20145250//SCG10 PROTEIN (SUPERIOR CERVICAL GANGLION-10 PROTEIN).//2.50E-58//141aa//88%//P55821
    • NT2NE20146510//HYPOTHETICAL 104.7 KDA PROTEIN F23F12.8 IN CHROMOSOME III PRECURSOR.//6.20E-08//179aa//23%//P46504
    • NT2NE20148690
    • NT2NE20149500
    • NT2NE20150610
    • NT2NE20152620
    • NT2NE20153620//mitogen inducible gene mig-2—human//7.90E-147//449aa//63%//S69890
    • NT2NE20155650//RETROVIRUS-RELATED ENV POLYPROTEIN.//2.30E-29//114aa//33%//P10267
    • NT2NE20157120
    • NT2NE20165190
    • NT2NE20167660//Mus musculus nuclear localization signal binding protein (spot-1) mRNA, complete cds.//3.50E-09//76aa//40%//S79410
    • NT2NE20173970//Rattus norvegicus beta-catenin binding protein mRNA, complete cds.//1.60E-24//134aa//46%//AF169825
    • NT2NE20177210//Leishmania major partial ppg1 gene for proteophosphoglycan.//1.10E-06//169aa//27%//AJ243460
    • NT2NE20181760
    • NT2NE20181800
    • NT2NE20184720
    • NT2RI20016240
    • NT2RI20021200
    • NT2RI20033920
    • NT2RI20093010//BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL PRECURSOR [INCLUDES: NAD-DEPENDENT METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.15); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9)].//5.90E-34//86aa//81%//P13995
    • NT2RP70001120//GA BINDING PROTEIN BETA-1 CHAIN (GABP-BETA-1 SUBUNIT) (GABPB1).//2.50E-113//384aa//62%//Q00420
    • NT2RP70001730//Mus musculus actin-binding protein (ENC-1) mRNA, complete cds.//4.30E-249//589aa//74%//U65079
    • NT2RP70003110//ELASTIN PRECURSOR (TROPOELASTIN).//1.40E-165//613aa//61%//P15502
    • NT2RP70012830//CALPHOTIN.//7.90E-17//445aa//28%//Q02910
    • NT2RP70022820
    • NT2RP70027190//RAS SUPPRESSOR PROTEIN 1 (RSU-1) (RSP-1 PROTEIN) (RSP-1).//3.80E-23//186aa//34%//Q01730
    • NT2RP70029780//ZINC FINGER PROTEIN ZFP-36 (FRAGMENT).//4.30E-118//381aa//56%//P16415
    • NT2RP70030840//Mus musculus schlafen3 (Slfn3) mRNA, complete cds.//3.70E-55//328aa//33%//AF099974
    • NT2RP70031070//36 KDA NUCLEOLAR PROTEIN HNP36 (DELAYED-EARLY RESPONSE PROTEIN 12) (DER12).//1.20E-23//169aa//34%//Q61672
    • NT2RP70031340
    • NT2RP70031480
    • NT2RP70035110//Caenorhabditis elegans UNC-89 (unc-89) gene, complete cds.//1.50E-07//229aa//26%//U33058
    • NT2RP70046410//BASONUCLIN.//3.60E-71//318aa//43%//Q01954
    • NT2RP70049610
    • NT2RP70056290
    • NT2RP70056690//F-SPONDIN PRECURSOR.//2.20E-15//366aa//24%//P35447
    • NT2RP70057500//Hypothetical zinc finger-like protein [Homo sapiens].//0//799aa//94%//AAF88107
    • NT2RP70064570//CALPAIN P94, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM-ACTIVATED NEUTRAL PROTEINASE) (CANP) (P94 PROTEIN) (MUSCLE-SPECIFIC CALCIUM-ACTIVATED NEUTRAL PROTEASE 3 LARGE SUBUNIT).//9.40E-86//278aa//40%//Q64691
    • NT2RP70074800
    • NT2RP70075300//ZINC FINGER PROTEIN 211 (ZINC FINGER PROTEIN C2H2-25).//9.60E-121//333aa//63%//Q13398
    • NT2RP70075800//HYPOTHETICAL 43.1 KDA TRP-ASP REPEATS CONTAINING PROTEIN K04G11.4 IN CHROMOSOME X.//1.80E-13//244aa//25%//Q93847
    • NT2RP70080150
    • NT2RP70084540
    • NT2RP70087140//SKIN SECRETORY PROTEIN XP2 PRECURSOR (APEG PROTEIN).//1.40E-11//264aa//31%//P17437
    • NT2RP70090870//ZINC FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10) (HPF7).//4.20E-230//592aa//61%//Q05481
    • NTONG20002230//Mus musculus RW1 protein mRNA, complete cds.//5.20E-97//546aa//34%//AF060565
    • NTONG20005310
    • NTONG20017620
    • NTONG20029850//CALCYPHOSINE (R2D5 ANTIGEN).//1.60E-24//183aa//32%//P41150
    • NTONG20031580//heat shock 27 kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein [Homo sapiens]//6.10E-69//141aa//95%//NP—055239
    • NTONG20032100//KERATIN, TYPE I CYTOSKELETAL 13 (CYTOKERATIN 13) (K13) (CK 13).//4.20E-175//351aa//96%//P13646
    • NTONG20034540//CGMP-DEPENDENT 3′,5′-CYCLIC PHOSPHODIESTERASE (EC 3.1.4.17) (CYCLIC GMP STIMULATED PHOSPHODIESTERASE) (CGS-PDE).//0//713aa//99%//000408
    • NTONG20035150//RING CANAL PROTEIN (KELCH PROTEIN).//9.10E-30//570aa//25%//Q04652
    • NTONG20043080//MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE AND NON-MUSCLE ISOZYMES (EC 2.7.1.117) (MLCK) [CONTAINS: TELOKIN].//4.30E-12//226aa//28%//P11799
    • NTONG20048440//P116 RHO-INTERACTING PROTEIN (P116RIP) (RIP3).//1.60E-269//588aa//87%//P97434
    • NTONG20049180
    • NTONG20053630//GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3) (GLUCAN 1,4-ALPHA-GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN GLUCOHYDROLASE).//1.30E-12//247aa//29%//P08640
    • NTONG20053730//UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 64E (EC 3.1.2.15) (UBIQUITIN THIOLESTERASE 64E) (UBIQUITIN-SPECIFIC PROCESSING PROTEASE 64E) (DEUBIQUITINATING ENZYME 64E).//8.70E-104//340aa//60%//Q24574
    • NTONG20053910//Bos taurus differentiation enhancing factor 1 (DEF-1) mRNA, complete cds.//2.50E-198//891aa//45%//AF112886
    • NTONG20055200//ELONGATION FACTOR G, MITOCHONDRIAL PRECURSOR (MEF-G).//1.10E-269//522aa//83%//Q07803
    • NTONG20058010//ACETYL-COENZYME A SYNTHETASE (EC 6.2.1.1) (ACETATE-COA LIGASE) (ACYL-ACTIVATING ENZYME).//3.90E-124//398aa//54%//068040
    • NTONG20058220//Homo sapiens phosphoprotein pp75 mRNA, partial cds.//8.60E-14//349aa//25%//AF153085
    • OCBBF20000740//Homo sapiens mRNA for ISLR, complete cds.//3.60E-87//287aa//59%//AB003184
    • OCBBF20001780
    • OCBBF20005220//Rattus norvegicus Fos-related antigen mRNA, complete cds.//3.40E-233//552aa//84%//U34932
    • OCBBF20009820
    • OCBBF20011860//Mus musculus epithelial protein lost in neoplasm-a (Eplin) mRNA, complete cds.//4.30E-33//98aa//66%//AF307844
    • OCBBF20012520//Homo sapiens mRNA for ISLR, complete cds.//6.50E-88//287aa//59%//AB003184
    • OCBBF20016390
    • OCBBF20016810//enhancer of polycomb [Mus musculus]//0//743aa//92%//AF079765
    • OCBBF20109450
    • OCBBF20109780
    • OCBBF20110210//KILON PROTEIN PRECURSOR (KINDRED OF IGLON).//4.30E-182//352aa//94%//Q9Z0J8
    • OCBBF20110730
    • OCBBF20111370//BCL2/ADENOVIRUS E1B 19-KDA PROTEIN-INTERACTING PROTEIN 2.//5.70E-84//324aa//52%//054940
    • OCBBF20111600//69 KDA ISLET CELL AUTOANTIGEN (ICA69) (ISLET CELL AUTOANTIGEN 1).//1.30E-113//335aa//57%//Q05084
    • OCBBF20112280//Mesembryanthemum crystallinum phosphoenolpyruvate/phosphate translocator precursor (PPT) mRNA, complete cds.//7.00E-09//113aa//30%//AF223359
    • OCBBF20112320
    • OCBBF20113110
    • OCBBF20115360
    • OCBBF20116250//Mus musculus C2H2-type zinc finger protein (Evi9) mRNA, complete cds.//0//592aa//99%//AF051525
    • OCBBF20117220
    • OCBBF20118720
    • OCBBF20119810
    • OCBBF20120010//Homo sapiens zinc metalloprotease ADAMTS6 (ADAMTS6) mRNA, complete cds.//1.60E-44//217aa//42%//AF140674
    • OCBBF20120950//ZINC FINGER PROTEIN 151 (POLYOMAVIRUS LATE INITIATOR PROMOTER BINDING PROTEIN) (LP-1) (ZINC FINGER PROTEIN Z13).//1.00E-28//201aa//34%//Q60821
    • OCBBF20121910//LAF-4 PROTEIN (LYMPHOID NUCLEAR PROTEIN).//0//740aa//98%//P51826
    • OCBBF20123200
    • OCBBF20142290
    • OCBBF20147070
    • OCBBF20152330
    • OCBBF20155030
    • OCBBF20156450//ZINC FINGER PROTEIN 75.//8.20E-163//289aa//99%//P51815
    • OCBBF20157970//ZINC FINGER PROTEIN 135.//2.80E-98//306aa//56%//P52742
    • OCBBF20160380//liver stage antigen LSA-1—Plasmodium falciparum//1.10E-21//938aa//24%//A45592
    • OCBBF20165900//CELL SURFACE ANTIGEN 114/A10 PRECURSOR.//4.80E-09//145aa//31%//P19467
    • OCBBF20165910//Mus musculus pecanex 1 mRNA, complete cds.//4.20E-116//407aa//53%//AF096286
    • OCBBF20166890//RESTIN (CYTOPLASMIC LINKER PROTEIN-170) (CLIP-170).//4.20E-21//124aa//45%//042184
    • OCBBF20166900//ZINC FINGER PROTEIN CLONE 647 (FRAGMENT).//9.00E-18//196aa//30%//P15622
    • OCBBF20167290//probable acyl-CoA dehydrogenase—Deinococcus radiodurans (strain R1)//2.50E-72//222aa//60%//D75616
    • OCBBF20170350//Mus musculus mRNA for GATS protein.//2.50E-56//121aa//96%//AJ296173
    • OCBBF20174580//G2/MITOTIC-SPECIFIC CYCLIN S13-7 (B-LIKE CYCLIN) (FRAGMENT).//7.10E-16//240aa//25%//P25012
    • OCBBF20174890//ankyrin 3, long splice form—human//1.10E-150//178aa//100%//A55575
    • OCBBF20175360//Homo sapiens C2H2 (Kruppel-type) zinc finger protein mRNA, complete cds.//3.80E-11//101aa//36%//AF159567
    • OCBBF20176650
    • OCBBF20177540//ZINC FINGER PROTEIN MLZ-4 (ZINC FINGER PROTEIN 46).//1.40E-110//223aa//86%//Q03309
    • OCBBF20177910
    • OCBBF20182060//Mesocricetus auratus guanine nucleotide-binding protein beta 5 (Gnb5) mRNA, complete cds.//7.20E-82//265aa//61%//U13152
    • OCBBF20185630
    • OCBBF20188280
    • OCBBF20191950//VERY LOW-DENSITY LIPOPROTEIN RECEPTOR PRECURSOR (VLDL RECEPTOR).//0//720aa//97%//P98155
    • PANCR10000860//ELASTASE IIIB PRECURSOR (EC 3.4.21.70) (PROTEASE E).//1.10E-52//87aa//97%//P08861
    • PEBLM10001470//glutamine (Q)-rich factor 1, QRF-1 [mice, B-cell leukemia, BCL1, Peptide Partial, 84 aa]//5.00E-42//84aa//98%//AAB29272
    • PEBLM20001800//IG ALPHA-1 CHAIN C REGION.//7.90E-197//353aa//100%//P01876
    • PEBLM20003260//ZINC FINGER PROTEIN 83 (ZINC FINGER PROTEIN HPF1).//4.90E-62//151aa//70%//P51522 PEBLM20005020
    • PLACE50001290//HYPOTHETICAL 87.9 KDA PROTEIN F44G4.1 IN CHROMOSOME II PRECURSOR.//2.90E-16//102aa//43%//P54073
    • PLACE50001390
    • PLACE60001910
    • PLACE60004260//CYSTATIN M PRECURSOR (CYSTATIN E).//1.50E-37//81aa//97%//Q15828
    • PLACE60006300
    • PLACE60011180
    • PLACE60012620//LYSOSOMAL TRAFFICKING REGULATOR (BEIGE HOMOLOG).//8.40E-14//128aa//38%//Q99698
    • PLACE60017120
    • PLACE60052940//TRANSCRIPTION REGULATORY PROTEIN GAL11.//1.70E-05//445aa//23%//P32257
    • PLACE60053280
    • PLACE60054230//DIAPHANOUS PROTEIN HOMOLOG 2.//1.00E-35//385aa//26%//060879
    • PLACE60054820//HYPOTHETICAL PROTEIN KIAA0032.//1.20E-50//180aa//61%//Q15034
    • PLACE60054870//MYOSIN HEAVY CHAIN, NONMUSCLE TYPE B (CELLULAR MYOSIN HEAVY CHAIN, TYPE B) (NMMHC-B).//3.70E-11//434aa//20%//P35580
    • PLACE60055350
    • PLACE60055460//Homo sapiens leucine-zipper protein FKSG13 (FKSG13) mRNA, complete cds.//5.40E-164//327aa//99%//AF312393
    • PLACE60055590//MYOSIN-BINDING PROTEIN H (MYBP-H) (H-PROTEIN) (86 KDA PROTEIN).//1.30E-05//124aa//35%//Q05623
    • PLACE60056910
    • PLACE60057860
    • PLACE60061370
    • PLACE60062660//ADP-ribosylation factor binding protein GGA1; ADP-ribosylation factor binding protein; Golgi-associated, gamma-adaptin ear containing, ARF-binding protein 1 [Homo sapiens].//6.00E-84//249aa//93%//NP—037497
    • PLACE60062870
    • PLACE60063940
    • PLACE60064180//PUTATIVE PRE-mRNA SPLICING FACTOR ATP-DEPENDENT RNA HELICASE.//1.90E-51//368aa//37%//022899
    • PLACE60064740//ADHESIVE PLAQUE MATRIX PROTEIN PRECURSOR (FOOT PROTEIN 1) (MCFP1).//4.80E-11//157aa//31%//Q25434
    • PLACE60066970//ZINC FINGER PROTEIN 191.//1.30E-36//115aa//48%//014754
    • PLACE60068710//SUPPRESSOR PROTEIN SRP40.//9.50E-43//238aa//50%//P32583
    • PLACE60069880
    • PLACE60070500
    • PLACE60071800//CORONIN-LIKE PROTEIN P57.//3.80E-60//108aa//81%//Q92176
    • PLACE60072390
    • PLACE60072420
    • PLACE60073090//Homo sapiens myo-inositol 1-phosphate synthase A1 (ISYNA1) mRNA, complete cds.//6.60E-219//362aa//98%//AF220530
    • PLACE60074820
    • PLACE60077870
    • PLACE60080360//mucin [Homo sapiens]//5.50E-05//164aa//30%//CAA84032
    • PLACE60081260
    • PLACE60082850
    • PLACE60087680//INSULIN-LIKE GROWTH. FACTOR BINDING PROTEIN 3 PRECURSOR (IGFBP-3) (IBP-3) (IGF-BINDING PROTEIN 3).//2.30E-103//255aa//79%//P17936
    • PLACE60088240
    • PLACE60092280
    • PLACE60092370
    • PLACE60093380
    • PLACE60095240
    • PLACE60095600//HYPOTHETICAL HELICASE C28H8.3 IN CHROMOSOME III.//2.70E-28//201aa//38%//Q09475
    • PLACE60098350//Human hepatocellular carcinoma associated protein (JCL-1) mRNA, complete cds.//5.20E-285//558aa//97%//U92544
    • PLACE60104630//macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Homo sapiens]//9.70E-51//10aa//93%//XP—000858
    • PLACE60105680//Homo sapiens mRNA for TU12B1-TY, complete cds.//1.70E-30//65aa//64%//AB032773
    • PLACE60107010//SUPPRESSOR PROTEIN SRP40.//3.80E-05//117aa//29%//P32583
    • PLACE60109910
    • PLACE60113340//BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN PRECURSOR(HSPG) (PERLECAN) (PLC).//5.90E-65//238aa//32%//Q05793
    • PLACE60118810//Rattus norvegicus kinesin light chain KLCt mRNA, complete cds.//1.90E-230//504aa//87%//AF166267
    • PLACE60119700//Homo sapiens mRNA for ABP32, complete cds.//2.30E-21//47aa//100%//AB018357
    • PLACE60120280//SER/THR-RICH PROTEIN T10 IN DGCR REGION.//6.00E-99//126aa//84%//P54797
    • PLACE60122970//novel C2H2 type zinc finger protein//5.60E-84//169aa//98%//CAC10457
    • PLACE60132200//TRICHIOHYALIN.//3.10E-47//297aa//47%//P37709
    • PLACE60132320
    • PLACE60132880
    • PLACE60138840//PUTATIVE MITOCHONDRIAL CARRIER PROTEIN PET8.//7.40E-59//274aa//47%//P38921
    • PLACE60140640//Homo sapiens nucleotide binding protein (NBP) mRNA, complete cds.//3.90E-138//262aa//99%//AF208536
    • PLACE60150510//NUCLEAR PROTEIN SNF7.//1.60E-11//189aa//25%//P39929
    • PLACE60154450//PUTATIVE PREOPTIC REGULATORY FACTOR-2 PRECURSOR (PORF-2).//7.30E-36//75aa//98%//P18890
    • PLACE60155910
    • PLACE60157310
    • PLACE60162100
    • PLACE60175640
    • PLACE60177880//IGSF5 [Homo sapiens].//3.60E-174//315aa//99%//CAB90447
    • PLACE60177910
    • PLACE60181870
    • PLACE60184410//Mus musculus peroxisomal long chain acyl-CoA thioesterase Ib (Pte1b) gene, exon 3 and complete cds.//1.00E-43//126aa//69%//AF180801
    • PLACE60184870//PHOSPHOLIPID TRANSFER PROTEIN PRECURSOR (LIPID TRANSFER PROTEIN II).//1.50E-227//330aa//99%//P55058
    • PLACE60188630//Mus musculus mRNA for acetylglucosaminyltransferase-like protein.//7.80E-08//317aa//23%//AJ006278
    • PROST10001100//Zea mays clone AGPZm1 arabinogalactan protein (agp) mRNA, partial cds.//5.80E-05//180aa//32%//AF134579
    • PROST10001360
    • PROST10002150
    • PROST20007170//Hypothetical Kruppel-Type Zinc Finger Protein (R28830—1)//0//432aa//100%//AAC24608
    • PROST20007600//PUTATIVE ENDONUCLEASE C1F12.06C (EC 3.1.-.-).//5.90E-29//134aa//44%//Q10348
    • PROST20011160
    • PROST20011800
    • PROST20014140
    • PROST20014150
    • PROST20014650
    • PROST20015210//MYOSIN HEAVY CHAIN, SMOOTH MUSCLE ISOFORM (SMMHC) (FRAGMENT).//3.00E-107//262aa//85%//P35749
    • PROST20015400
    • PROST20016760//M-PHASE PHOSPHOPROTEIN 8 (FRAGMENT).//9.00E-157//298aa//99%//Q99549
    • PROST20022120
    • PROST20024250//ZINC FINGER PROTEIN 136.//1.70E-45//128aa//63%//P52737
    • PROST20028970//Oryctolagus cuniculus CARP mRNA, complete cds.//4.80E-44//177aa//51%//AF131883
    • PROST20033240//EPHRIN TYPE-A RECEPTOR 6 PRECURSOR (EC 2.7.1.112) (TYROSINE-PROTEIN KINASE RECEPTOR EHK-2) (EPH HOMOLOGY KINASE-2).//8.40E-241//441aa//95%//Q62413
    • PROST20035170//Homo sapiens zinc finger protein dp mRNA, complete cds.//3.40E-15//128aa//42%//AF153201
    • PROST20035830
    • PROST20036280
    • PROST20036350//MULTIFUNCTIONAL AMINOACYL-TRNA SYNTHETASE [INCLUDES: GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE-TRNA LIGASE); PROLYL-TRNA SYNTHETASE (EC 6.1.1.15) (PROLINE-TRNA LIGASE)].//2.20E-137//651aa//42%//P07814
    • PROST20039300//Bos taurus mitochondrial mRNA for xenobiotic/medium-chain fatty acid:CoA ligase form XL-III.//1.60E-68//180aa//68%//AJ132751
    • PROST20041460
    • PROST20042700
    • PROST20045700//Zea mays clone AGPZm1 arabinogalactan protein (agp) mRNA, partial cds.//5.80E-05//180aa//32%//AF134579
    • PROST20047440
    • PROST20048170
    • PROST20050390//CYTOCHROME P450 2J2 (EC 1.14.14.1) (CYPIIJ2) (ARACHIDONIC ACID EPOXYGENASE).//1.40E-34//188aa//42%//P51589
    • PROST20051310//Homo sapiens DEAD-box protein abstrakt (ABS) mRNA, complete cds.//8.50E-134//257aa//99%//AF195417
    • PROST20052720
    • PROST20052850//CYCLIN G-ASSOCIATED KINASE (EC 2.7.1.-).//2.20E-18//107aa//54%//P97874
    • PROST20054660
    • PROST20058860//SMALL NUCLEAR RIBONUCLEOPROTEIN ASSOCIATED PROTEINS B AND B′ (SNRNP-B) (SM PROTEIN B/B′) (SM-B/SM-B′).//8.20E-05//134aa//33%//P14678
    • PROST20060200
    • PROST20062820//TRANSLATION INITIATION FACTOR IF-2.//1.50E-07//102aa//41%//P71613
    • PROST20063430//BCL2/ADENOVIRUS E1B 19-KDA PROTEIN-INTERACTING PROTEIN 2.//8.50E-74//305aa//46%//Q12982
    • PROST20065100
    • PROST20065790//6-PHOSPHOFRUCTOKINASE, TYPE C (EC 2.7.1.11) (PHOSPHOFRUCTOKINASE 1) (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTO-1-KINASE ISOZYME C) (6-PHOSPHOFRUCTOKINASE, PLATELET TYPE).//0//697aa//99%//Q01813
    • PROST20073280
    • PROST20075280//MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE AND NON-MUSCLE ISOZYMES (EC 2.7.1.117) (MLCK) [CONTAINS: TELOKIN].//1.30E-08//245aa//23%//P11799
    • PROST20078710
    • PROST20082430
    • PROST20084470//Plasmodium berghei strain NYU2 merozoite surface protein-1 mRNA, partial cds.//2.50E-08//122aa//28%//AF000413
    • PROST20084680
    • PROST20084720//CYTOCHROME P450 4F2 (EC 1.14.13.30) (CYPIVF2) (LEUKOTRIENE-B4 OMEGA-HYDROXYLASE) (LEUKOTRIENE-B4 20-MONOOXYGENASE) (CYTOCHROME P450-LTB-OMEGA).//1.50E-37//85aa//85%//P78329
    • PROST20087240
    • PROST20093470
    • PROST20094000
    • PROST20097310
    • PROST20097360
    • PROST20097840//SYNAPSIN I.//1.80E-09//193aa//34%//P17599
    • PROST20099090//ADAM 12 PRECURSOR (EC 3.4.24.-) (A DISINTEGRIN AND METALLOPROTEINASE DOMAIN 12) (MELTRIN ALPHA).//1.90E-22//73aa//60%//043184
    • PROST20102190//CALMODULIN.//1.30E-20//98aa//47%//P02594
    • PROST20102500
    • PROST20103820
    • PROST20105450//SODIUM/HYDROGEN EXCHANGER 6 (NA(+)/H(+) EXCHANGER 6) (NHE-6) (KIAA0267).//1.60E-96//214aa//75%//Q92581
    • PROST20106060
    • PROST20108850//MICROSOMAL SIGNAL PEPTIDASE 23 KDA SUBUNIT (EC 3.4.-.-) (SPC22/23).//1.20E-69//132aa//100%//P12280
    • PROST20110120
    • PROST20114100
    • PROST20120070//KINESIN HEAVY CHAIN (UBIQUITOUS KINESIN HEAVY CHAIN) (UKHC).//5.00E-05//286aa//24%//P33176
    • PROST20121570
    • PROST20122490//Gallus gallus syndesmos mRNA, complete cds.//1.20E-63//139aa//84%//AF095446
    • PROST20124000
    • PROST20125420
    • PROST20127450//Homo sapiens TSC-22 related protein (TSC-22R) mRNA, complete cds.//7.90E-44//95aa//98%//AF153603
    • PROST20130320
    • PROST20138730
    • PROST20146590//MUCIN 1 PRECURSOR (POLYMORPHIC EPITHELIAL MUCIN) (PEM) (PEMT) (EPISIALIN) (TUMOR-ASSOCIATED MUCIN) (CARCINOMA-ASSOCIATED MUCIN) (TUMOR-ASSOCIATED EPITHELIAL MEMBRANE ANTIGEN) (EMA) (H23AG) (PEANUT-REACTIVE URINARY MUCIN) (PUM) (BREAST CARCINOMA-ASSOCIATED ANTIGEN DF3).//3.50E-08//556aa//23%//P15941
    • PROST20151370//Human probable zinc finger protein H101 mRNA, partial cds.//1.60E-11//104aa//41%//U81557
    • PROST20152510//UDP-N-ACETYLGLUCOSAMINE-PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 100 KDA SUBUNIT (EC 2.4.1.-) (O-GLCNAC TRANSFERASE P100 SUBUNIT).//6.00E-17//148aa//34%//015294
    • PROST20152870//Homo sapiens APC2 gene, exon 14.//1.60E-05//195aa//30%//AJ131187 PROST20155370//ZINC FINGER PROTEIN 38 (ZFP-38) (CTFIN51) (TRANSCRIPTION FACTOR RU49).//1.10E-72//140aa//55%//Q07231
    • PROST20156360
    • PROST20159320
    • PROST20168600//Homo sapiens six transmembrane epithelial antigen of prostate (STEAP1) mRNA, complete cds.//1.20E-70//237aa//54%//AF186249
    • PUAEN10000650//Homo sapiens TSC-22 related protein (TSC-22R) mRNA, complete cds.//7.90E-44//95aa//98%//AF153603
    • PUAEN10000870
    • PUAEN10001640//Mus musculus cerebellar postnatal development protein-1 (Cpd1) mRNA, partial cds.//2.80E-126//270aa//90%//U89345
    • PUAEN20000800
    • PUAEN20001520//L-A VIRUS GAG PROTEIN N-ACETYLTRANSFERASE (EC 2.3.1.-).//1.70E-34//145aa//51%//Q03503
    • PUAEN20002470//PROTEIN MOV-10.//6.30E-102//405aa//44%//P23249
    • PUAEN20003120//ENHANCER OF ZESTE HOMOLOG 2 (ENX-1).//0//643aa//97%//Q15910
    • SALGL10001070//CH-TOG PROTEIN (COLONIC AND HEPATIC TUMOR OVER-EXPRESSED PROTEIN) (KIAA0097).//5.30E-150//297aa//96%//Q14008
    • SKMUS20006790
    • SKMUS20007260//MICROTUBULE-ASSOCIATED PROTEIN 1B (MAP1.2) (MAP1(X)) [CONTAINS: MAP1 LIGHT CHAIN LC1].//8.10E-05//396aa//23%//P14873
    • SKMUS20008730//smoothelin large isoform L2 [Homo sapiens].//1.20E-221//217aa//98%//AAF01481
    • SKMUS20017400//TROPOMYOSIN ALPHA CHAIN, SKELETAL MUSCLE TYPE.//3.20E-97//242aa//81%//P06753
    • SKMUS20020770
    • SKMUS20026340
    • SKMUS20040440//60S RIBOSOMAL PROTEIN L3 (HIV-1 TAR RNA BINDING PROTEIN B) (TARBP-B).//3.60E-189//229aa//99%//P39023
    • SKMUS20064810
    • SKMUS20073150//20-HYDROXYECDYSONE PROTEIN PRECURSOR (20-HE).//1.50E-05//129aa//32%//P29681
    • SKMUS20073590//tropomodulin 4 (muscle) [Homo sapiens]//3.90E-58//115aa//100%//NP—037485
    • SKMUS20079150//splicing factor 3a, subunit 3, 60 kD; pre-mRNA splicing factor SF3a (60 kD), similar to S. cerevisiae PRP9 (spliceosome-associated protein 61) [Homo sapiens]//9.10E-13//65aa//60%//NP—006793
    • SKMUS20091900
    • SKNMC10001230//CYCLIN-DEPENDENT KINASE 4 INHIBITOR A (CDK4I) (P16-INK4) (P16-INK4A) (TUMOR SUPPRESSOR CDKN2A).//1.60E-08//105aa//38%//077617
    • SKNMC20006350//65 KDA FK506-BINDING PROTEIN PRECURSOR (EC 5.2.1.8) (FKBP65) (FKBPRP) (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) (IMMUNOPHILIN FKBP65).//1.10E-185//419aa//79%//Q61576
    • SKNSH10001010
    • SKNSH20007160
    • SKNSH20009710//TROPOMYOSIN, CYTOSKELETAL TYPE (TM30-NM).//3.20E-74//174aa//86%//P12324
    • SKNSH20030640//SPLICEOSOME ASSOCIATED PROTEIN 62 (SAP 62) (SF3A66).//3.00E-06//127aa//33%//Q62203
    • SKNSH20040390
    • SKNSH20052400//VEGETATIBLE INCOMPATIBILITY PROTEIN HET-E-1.//3.60E-17//175aa//29%//Q00808
    • SKNSH20057920//CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE I (EC 2.7.1.123) (CAM KINASE I).//5.00E-37//197aa//40%//Q14012
    • SKNSH20068220
    • SKNSH20094350
    • SMINT20000070//Mus musculus mRNA for granuphilin-b, complete cds.//2.70E-44//128aa//41%//AB025259
    • SMINT20002320//SERINE/THREONINE PROTEIN PHOSPHATASE 2A, 56 KDA REGULATORY SUBUNIT, BETA ISOFORM (PP2A, B SUBUNIT, B′ BETA ISOFORM) (PP2A, B SUBUNIT, B56 BETA ISOFORM) (PP2A, B SUBUNIT, PR61 BETA ISOFORM) (PP2A, B SUBUNIT, R5 BETA ISOFORM).//4.70E-160//299aa//100%//Q15173
    • SMINT20006020//faciogenital dysplasia protein 2 [Mus musculus]//4.10E-158//327aa//87%//AF017368
    • SMINT20006090//Oryctolagus cuniculus mRNA for parchorin, complete cds.//7.50E-87//175aa//93%//AB035520
    • SMINT20007470//TRICHOHYALIN.//1.20E-37//492aa//28%//Q07283
    • SMINT20008110//CALCIUM-TRANSPORTING ATPASE 2C1 (EC 3.6.1.38) (ATP-DEPENDENT CA2+ PUMP PMR1).//1.20E-50//165aa//63%//P98194
    • SMINT20011830
    • SMINT20011950//ZINC FINGER PROTEIN 202.//1.90E-67//426aa//40%//095125
    • SMINT20012220
    • SMINT20013970
    • SMINT20014610
    • SMINT20016150//FERRITIN LIGHT CHAIN (FERRITIN L SUBUNIT).//3.50E-91//174aa//100%//P02792
    • SMINT20017310
    • SMINT20021260
    • SMINT20023110
    • SMINT20024140//IG KAPPA CHAIN V-IV REGION B17 PRECURSOR.//1.20E-60//134aa//87%//P06314
    • SMINT20026200//ENL PROTEIN.//1.10E-05//260aa//24%//Q03111
    • SMINT20028800//tumor supressor protein—fruit fly (Drosophila melanogaster).//2.00E-78//493aa//34%//T13797
    • SMINT20028840//CMRF35 ANTIGEN PRECURSOR.//8.40E-19//136aa//41%//Q08708
    • SMINT20030740//ZINC FINGER PROTEIN 136.//4.50E-194//535aa//63%//P52737
    • SMINT20031280
    • SMINT20035050//GTPASE ACTIVATING PROTEIN BEM2/IPL2.//1.20E-07//134aa//26%//P39960
    • SMINT20035510//Drosophila melanogaster La related protein (larp) mRNA, partial cds.//5.40E-39//334aa//30%//AF221108
    • SMINT20036440//Drosophila melanogaster epsin-like protein mRNA, complete cds./12.90E-69//446aa//41%//AF233291
    • SMINT20038660//Homo sapiens HNOEL-iso (HNOEL-iso) mRNA, complete cds.//5.60E-201//368aa//99%//AF201945
    • SMINT20039050//Homo sapiens TRIAD3 mRNA, partial cds.//3.20E-86//156aa//100%//AF228527
    • SMINT20043390
    • SMINT20044140//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//3.50E-39//440aa//28%//P51523
    • SMINT20044730//UBIQUINONE BIOSYNTHESIS PROTEIN AARF.//6.20E-22//272aa//27%//P27854
    • SMINT20045470
    • SMINT20045830
    • SMINT20045890
    • SMINT20047290
    • SMINT20048720
    • SMINT20049920//CYTOSOLIC PURINE 5′-NUCLEOTIDASE (EC 3.1.3.5).//4.10E-39//132aa//57%//P49902
    • SMINT20052130//Rattus norvegicus mRNA for gankyrin homologue, complete cds.//9.20E-07//104aa//33%//AB022014
    • SMINT20054050//ABC1 PROTEIN HOMOLOG PRECURSOR.//1.40E-98//467aa//45%//Q92338
    • SMINT20056230//Ig mu chain precursor, membrane-bound (clone 201)—human//5.60E-233//422aa//78%//S14683
    • SMINT20056240
    • SMINT20062050//PLECTIN.//7.50E-17//436aa//25%//P30427
    • SMINT20067080
    • SMINT20070620
    • SMINT20074330//tektin A1 [Strongylocentrotus purpuratus]//3.10E-26//125aa//45%//M97188
    • SMINT20077920
    • SMINT20077960//GELSOLIN PRECURSOR, PLASMA (ACTIN-DEPOLYMERIZING FACTOR) (ADF) (BREVIN) (AGEL).//3.30E-246//459aa//99%//P06396
    • SMINT20081330
    • SMINT20083290//IG ALPHA-1 CHAIN C REGION.//4.40E-196//352aa//99%//P01876
    • SMINT20084910
    • SMINT20085310
    • SMINT20085450
    • SMINT20086250//GLYCINE CLEAVAGE SYSTEM H PROTEIN PRECURSOR.//2.20E-40//70aa//97%//P23434
    • SMINT20086720//ZINC FINGER PROTEIN 191.//1.40E-29//109aa//55%//014754
    • SMINT20088440//IG KAPPA CHAIN V-II REGION RPMI 6410 PRECURSOR.//5.10E-44//117aa//78%//P06310
    • SMINT20088690
    • SMINT20089210
    • SMINT20089600//Homo sapiens mRNA for PICK1, complete cds.//3.10E-145//278aa//100%//AB026491
    • SMINT20091190//IG ALPHA-1 CHAIN C REGION.//3.70E-198//353aa//99%//P01876
    • SMINT20092120
    • SMINT20092160
    • SMINT20093630
    • SMINT20094150
    • SMINT20094680//Homo sapiens mawbp mRNA for MAWD binding protein, complete cds.//2.80E-50//77aa//100%//AB049758
    • SPLEN20005160
    • SPLEN20005370
    • SPLEN20006950
    • SPLEN20011350
    • SPLEN20012450
    • SPLEN20015030
    • SPLEN20015100//HYPOTHETICAL 72.5 KDA PROTEIN C2F7.10 IN CHROMOSOME I.//7.50E-16//121aa//36%//Q09701
    • SPLEN20016500
    • SPLEN20017610
    • SPLEN20017810
    • SPLEN20019120
    • SPLEN20020530
    • SPLEN20023430
    • SPLEN20023540//H. sapiens mRNA for F25B3.3 kinase like protein from C. elegans.//1.50E-205//385aa//99%//Y12336
    • SPLEN20023850//DNA REPAIR PROTEIN RAD18.//3.00E-56//469aa//30%//P53692
    • SPLEN20024190//EGF-containing fibulin-like extracellular matrix protein 1; fibrillin-like [Homo sapiens]//3.70E-192//327aa//99%//NP—061489
    • SPLEN20024510
    • SPLEN20024620//Homo sapiens mRNA for acetyl LDL receptor, complete cds.//1.00E-217//401aa//100%//D86864
    • SPLEN20024770//Rattus norvegicus (rsec6) mRNA, complete cds.//2.10E-88//545aa//31%//U32575
    • SPLEN20024930//Rattus norvegicus PIPP mRNA for proline-rich inositol polyphosphate 5-phosphatase, complete cds.//0//639aa//91%//AB032551
    • SPLEN20029170
    • SPLEN20036780
    • SPLEN20039180//TENSIN.//2.70E-135//341aa//65%//Q04205
    • SPLEN20040780//CORNIFIN B (SMALL PROLINE-RICH PROTEIN 1B) (SPR1B) (SPR1 B).//5.10E-12//110aa//37%//Q62267
    • SPLEN20041810//BC-2 protein [Homo sapiens]//4.00E-24//59aa//96%//AF042384
    • SPLEN20042200//TRANSCRIPTIONAL REPRESSOR CTCF.//8.40E-22//127aa//33%//P49711
    • SPLEN20043430
    • SPLEN20043460
    • SPLEN20043680//DNA-REPAIR PROTEIN COMPLEMENTING XP-D CELLS (XERODERMA PIGMENTOSUM GROUP D COMPLEMENTING PROTEIN) (DNA EXCISION REPAIR PROTEIN ERCC-2).//7.30E-171//325aa//99%//P18074
    • SPLEN20045550
    • SPLEN20048800//Homo sapiens mRNA for N-Acetylglucosamine kinase.//1.90E-51//104aa//100%//AJ242910
    • SPLEN20049840//M. musculus mRNA for myosin I.//0//1093aa//89%//X97650
    • SPLEN20050090//TRICHOHYALIN.//7.20E-17//554aa//23%//P37709
    • SPLEN20051420
    • SPLEN20054160//Dof protein [Drosophila melanogaster]//9.60E-14//222aa//29%//AJ010641
    • SPLEN20054500//Homo sapiens mRNA for putative dipeptidase.//7.10E-130//244aa//100%//AJ295149
    • SPLEN20055600//ZINC FINGER PROTEIN 46 (ZINC FINGER PROTEIN KUP).//3.00E-56//155aa//63%//P24278
    • SPLEN20057830//REGULATOR OF MITOTIC SPINDLE ASSEMBLY 1 (RMSA-1).//1.10E-16//139aa//43%//P49646
    • SPLEN20057900//Homo sapiens N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase mRNA, complete cds.//9.00E-75//130aa//93%//AF187072
    • SPLEN20058180
    • SPLEN20059270//ZINC-FINGER PROTEIN RFP (RET FINGER PROTEIN).//7.20E-61//497aa//31%//P14373
    • SPLEN20062830
    • SPLEN20063250//zinc finger protein nocA—fruit fly (Drosophila melanogaster)//9.00E-16//364aa//30%//A55929
    • SPLEN20063890//FIBROMODULIN PRECURSOR (FM) (COLLAGEN-BINDING 59 KDA PROTEIN).//2.60E-118//242aa//94%//Q06828
    • SPLEN20067010
    • SPLEN20071820//Homo sapiens DNA polymerase mu (Pol mu) mRNA, complete cds.//4.70E-62//116aa//100%//AF176097
    • SPLEN20073500//TUMOR NECROSIS FACTOR, ALPHA-INDUCED PROTEIN 2 (B94 PROTEIN).//3.50E-10//463aa//25%//Q03169
    • SPLEN20073880
    • SPLEN20076190
    • SPLEN20076470//KINESIN LIGHT CHAIN (KLC).//2.40E-18//137aa//38%//P46825
    • SPLEN20080070//TISSUE ALPHA-L-FUCOSIDASE PRECURSOR (EC 3.2.1.51) (ALPHA-L-FUCOSIDASE I) (ALPHA-L-FUCOSIDE FUCOHYDROLASE).//4.70E-253//359aa//98%//P04066
    • SPLEN20081640
    • SPLEN20085910//Homo sapiens protein activator of the interferon-induced protein kinase (PACT) mRNA, complete cds.//2.90E-23//52aa//100%//AF072860
    • SPLEN20087370
    • SPLEN20087860
    • SPLEN20090880//HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-24(A-9) ALPHA CHAIN PRECURSOR (AW-24).//1.40E-66//153aa//83%//P05534
    • SPLEN20098030//TRANSCRIPTION INTERMEDIARY FACTOR 1-BETA (NUCLEAR COREPRESSOR KAP-1) (KRAB-ASSOCIATED PROTEIN 1).//4.00E-18//267aa//26%//Q13263
    • SPLEN20100040//258.1 KDA PROTEIN C210RF5 (KIAA0933).//7.90E-46//223aa//43%//Q9Y3R5
    • SPLEN20101950//SODIUM/HYDROGEN EXCHANGER 6 (NA(+)/H(+) EXCHANGER 6) (NHE-6) (KIAA0267).//7.70E-112//353aa//61%//Q92581
    • SPLEN20104150
    • SPLEN20104690
    • SPLEN20105100
    • SPLEN20108000//Homo sapiens steroid dehydrogenase homolog mRNA, complete cds.//9.30E-73//155aa//94%//AF078850
    • SPLEN20108460
    • SPLEN20110180//Homo sapiens golgi membrane protein GP73 mRNA, complete cds.//1.60E-162//347aa//91%//AF236056
    • SPLEN20110210
    • SPLEN20110860
    • SPLEN20111450
    • SPLEN20114190
    • SPLEN20116720//Homo sapiens misato mRNA, partial cds.//1.00E-277//481aa//89%//AF272833
    • SPLEN20117580
    • SPLEN20118050//BONE/CARTILAGE PROTEOGLYCAN I PRECURSOR (BIGLYCAN) (PG-S1).//1.00E-123//240aa//97%//P21810
    • SPLEN20121790
    • SPLEN20125230
    • SPLEN20126110
    • SPLEN20135030//Homo sapiens PDZ-LIM protein mystique mRNA, complete cds.//3.30E-92//178aa//97%//AY007729
    • SPLEN20136700
    • SPLEN20136730//Homo sapiens RAB-like protein 2A (RABL2A) mRNA, complete cds.//9.30E-41//102aa//90%//AF095350
    • SPLEN20137530
    • SPLEN20138600//NUMB protein [Homo sapiens].//1.00E-97//102aa//100%//AAD01548
    • SPLEN20139100//Human (hybridoma H210) anti-hepatitis A IgG variable region, constant region, complementarity-determining regions mRNA, complete cds.//2.30E-227//490aa//85%//M87789
    • SPLEN20139360//MAJOR CENTROMERE AUTOANTIGEN B (CENTROMERE PROTEIN B) (CENP-B).//5.10E-35//295aa//32%//P07199
    • SPLEN20175920
    • SPLEN20176130//Homo sapiens mRNA for ALEX1, complete cds.//9.90E-21//161aa//32%//AB039670
    • SPLEN20177400
    • SPLEN20180980//METHIONYL-TRNA SYNTHETASE (EC 6.1.1.10) (METHIONINE-TRNA LIGASE) (METRS).//3.40E-57//133aa//87%//P56192
    • SPLEN20181570//TRICHOHYALIN.//7.80E-45//832aa//23%//P37709
    • SPLEN20182850
    • SPLEN20182990//Mus musculus actin-binding protein (ENC-1) mRNA, complete cds.//1.90E-49//586aa//26%//U65079
    • SPLEN20183020//BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN PRECURSOR(HSPG) (PERLECAN) (PLC).//1.20E-24//128aa//46%//Q05793
    • SPLEN20183950
    • SPLEN20187490//RESTIN (CYTOPLASMIC LINKER PROTEIN-170 ALPHA-2) (CLIP-170) (REED-STERNBERG INTERMEDIATE FILAMENT ASSOCIATED PROTEIN).//5.10E-09//411aa//22%//P30622
    • SPLEN20190080
    • SPLEN20190430//NEURALIZED PROTEIN.//2.80E-09//181aa//27%//P29503
    • SPLEN20190770
    • SPLEN20191020//Homo sapiens MIST mRNA, partial cds.//1.50E-207//376aa//99%//AB032369
    • SPLEN20192570
    • SPLEN20193230
    • SPLEN20193490
    • SPLEN20193750
    • SPLEN20193790//INTERFERON-REGULATED RESISTANCE GTP-BINDING PROTEIN MXA (INTERFERON-INDUCED PROTEIN P78) (IFI-78K).//0//572aa//98%//P20591
    • SPLEN20195710//KINESIN LIGHT CHAIN (KLC).//5.80E-28//145aa//45%//P46824
    • SPLEN20197090
    • SPLEN20197740
    • SPLEN20197930//Rattus norvegicus putative transcription factor LUZP (Luzp) mRNA, complete cds.//6.10E-124//275aa//90%//AF181259
    • SPLEN20198390//TIPD PROTEIN.//2.80E-52//307aa//37%//015736
    • SPLEN20199850
    • SPLEN20200070
    • SPLEN20200340
    • SPLEN20201830//BONE/CARTILAGE PROTEOGLYCAN I PRECURSOR (BIGLYCAN) (PG-S1).//2.50E-152//283aa//100%//P21810
    • SPLEN20203590
    • SPLEN20204670
    • SPLEN20205120
    • TESOP10000350
    • TESOP10001600
    • TESTI10000190//MUCIN 1 PRECURSOR (POLYMORPHIC EPITHELIAL MUCIN) (PEM) (PEMT) (EPISIALIN) (TUMOR-ASSOCIATED MUCIN) (CARCINOMA-ASSOCIATED MUCIN) (TUMOR-ASSOCIATED EPITHELIAL MEMBRANE ANTIGEN) (EMA) (H23AG) (PEANUT-REACTIVE URINARY MUCIN) (PUM) (BREAST CARCINOMA-ASSOCIATED ANTIGEN DF3).//1.40E-23//667aa//28%//P15941
    • TESTI10000850
    • TESTI10001570//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//1.30E-148//598aa//46%//P51523
    • TESTI20004310//TRICHOHYALIN.//1.40E-07//247aa//25%//P22793
    • TESTI20005980
    • TESTI20006160//CALCIUM-BINDING PROTEIN.//1.10E-11//260aa//28%//P35085
    • TESTI20006830//GAR2 PROTEIN.//2.90E-05//221aa//19%//P41891
    • TESTI20012080//TUBULIN-TYROSINE LIGASE (EC 6.3.2.25) (TTL).//2.20E-22//217aa//35%//P38584
    • TESTI20012360
    • TESTI20016970
    • TESTI20019590
    • TESTI20028020
    • TESTI20029100//FIBROSIN (FRAGMENT).//1.60E-10//70aa//48%//Q60791
    • TESTI20030200//DOUBLE-STRANDED RNA-SPECIFIC EDITASE 1 (EC 3.5.-.-) (DSRNA ADENOSINE DEAMINASE) (RNA EDITING ENZYME 1).//1.90E-30//192aa//38%//P51400
    • TESTI20030440//TRICHOHYALIN.//2.80E-21//412aa//26%//P37709
    • TESTI20030610
    • TESTI20031310//ALPHA-1-ANTICHYMOTRYPSIN PRECURSOR (ACT).//7.80E-222//423aa//99%//P01011
    • TESTI20031410//SYNAPTONEMAL COMPLEX PROTEIN 1 (SCP-1 PROTEIN).//6.10E-11//449aa//24%//Q03410
    • TESTI20032770//ANTER-SPECIFIC PROLINE-RICH PROTEIN APG PRECURSOR.//1.40E-07//121aa//37%//P40602
    • TESTI20034750
    • TESTI20035330
    • TESTI20035790//SPLICING FACTOR, ARGININE/SERINE-RICH 4 (PRE-mRNA SPLICING FACTOR SRP75).//2.30E-44//346aa//37%//Q08170
    • TESTI20038240//Mus musculus neprilysin-like metallopeptidase 1 (Nl1) mRNA, complete cds.//0//770aa//77%//AF176569
    • TESTI20040850
    • TESTI20041630//Mus musculus mRNA for type II cytokeratin, complete cds.//1.30E-151//407aa//75%//AB033744
    • TESTI20043130
    • TESTI20043180//mouse mRNA for megakaryocyte potentiating factor, complete cds.//8.40E-06//392aa//24%//D86370
    • TESTI20043220//ORM1 PROTEIN.//6.40E-21//138aa//37%//P53224
    • TESTI20043910
    • TESTI20043990//APOMUCIN (MUCIN CORE PROTEIN) (FRAGMENT).//8.70E-64//283aa//53%//P12021
    • TESTI20044900//Strongylocentrotus purpuratus radial spokehead mRNA, complete cds.//2.50E-150//447aa//61%//U73123
    • TESTI20045390//Homo sapiens adlican mRNA, complete cds.//1.80E-173//632aa//47%//AF245505
    • TESTI20045740
    • TESTI20046110
    • TESTI20046490//Homo sapiens B2 gene partial cDNA, clone B2E.//4.30E-33//284aa//34%//AJ002220
    • TESTI20046540
    • TESTI20046870//RETINAL-BINDING PROTEIN (RALBP).//4.00E-06//244aa//23%//P49193
    • TESTI20046890//Mus musculus axotrophin mRNA, complete cds.//2.30E-40//173aa//53%//AF155739
    • TESTI20047370//ATROPHIN-1 (DENTATORUBRAL-PALLIDOLUYSIAN ATROPHY PROTEIN).//1.90E-22//695aa//28%//P54258
    • TESTI20047930//Homo sapiens NY-REN-2 antigen mRNA, complete cds.//1.50E-191//530aa//67%//AF155095
    • TESTI20049060//H. sapiens mRNA for SIRP-beta1.//2.50E-31//172aa//45%//Y10376
    • TESTI20049410
    • TESTI20049990
    • TESTI20050170
    • TESTI20050400
    • TESTI20050720//SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE PRECURSOR (EC 2.8.3.5) (SUCCINYL COA:3-OXOACID COA-TRANSFERASE) (OXCT).//1.40E-208//519aa//74%//P55809
    • TESTI20051200//POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE (EC 2.4.1.41) (PROTEIN-UDP ACETYLGALACTOSAMINYLTRANSFERASE) (UDP-GALNAC:POLYPEPTIDE, N-ACETYLGALACTOSAMINYLTRANSFERASE) (GALNAC-T1).//6.10E-50//189aa//49%//Q10472
    • TESTI20051730//MALTOSE PERMEASE.//2.20E-05//327aa//23%//Q45632
    • TESTI20052670
    • TESTI20053070//HYPOTHETICAL WD-REPEAT PROTEIN SLL0163.//5.00E-06//172aa//28%//Q55563
    • TESTI20053260
    • TESTI20053780
    • TESTI20053800
    • TESTI20053950
    • TESTI20054700//Streptococcus pneumoniae strain g375 surface protein PspC (pspC) gene, pspC-8.1 allele, complete cds.//6.70E-11//219aa//32%//AF154015
    • TESTI20055680//TRANSLATION INITIATION FACTOR IF-2.//5.90E-08//98aa//41%//060841
    • TESTI20055880
    • TESTI20056030//Homo sapiens 88-kDa Golgi protein (GM88) mRNA, complete cds.//3.60E-103//316aa//68%//AF204231
    • TESTI20057200
    • TESTI20057430//ZINC FINGER PROTEIN 8 (ZINC FINGER PROTEIN HF.18) (FRAGMENT).//3.00E-307//543aa//99%//P17098
    • TESTI20057590//TYROSINE-PROTEIN KINASE-LIKE 7 PRECURSOR(COLON CARCINOMA KINASE-4) (CCK-4).//7.80E-07//152aa//27%//Q13308
    • TESTI20057840//INHIBITOR OF APOPTOSIS PROTEIN (IAP) (INHIBITOR OF T CELL APOPTOSIS PROTEIN).//7.20E-08//86aa//36%//Q90660
    • TESTI20057880//CALDESMON (CDM).//6.20E-08//203aa//29%//P12957
    • TESTI20058350//SERINE/THREONINE PROTEIN PHOSPHATASE 2A, 55 KDA REGULATORY SUBUNIT B, GAMMA ISOFORM (PP2A, SUBUNIT B, B-GAMMA ISOFORM) (PP2A, SUBUNIT B, B55-GAMMA ISOFORM) (PP2A, SUBUNIT B, PR55-GAMMA ISOFORM) (PP2A, SUBUNIT B, R2-GAMMA ISOFORM).//2.00E-232//426aa//99%//P50410
    • TESTI20058920//TUBULIN ALPHA-3/ALPHA-7 CHAIN.//3.50E-148//277aa//98%//P05214
    • TESTI20059080//Homo sapiens hyaluronidase (LUCA-3) mRNA, complete cds.//2.40E-170//298aa//100%//AF040710
    • TESTI20059330
    • TESTI20059370
    • TESTI20059480
    • TESTI20059790
    • TESTI20059810//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//7.50E-153//536aa//52%//P51523
    • TESTI20060080//MYOSIN HEAVY CHAIN, CLONE 203 (FRAGMENT).//5.30E-09//236aa//24%//P39922
    • TESTI20060150
    • TESTI20060350
    • TESTI20060450
    • TESTI20060830//Mus musculus mRNA for MIWI (piwi), complete cds.//0//824aa//94%//AB032604
    • TESTI20061090
    • TESTI20061200//NITRITE EXTRUSION PROTEIN (NITRITE FACILITATOR).//4.90E-05//379aa//23%//P46907
    • TESTI20062120//poly(A)-specific ribonuclease (deadenylation nuclease); deadenylation nuclease [Homo sapiens]//1.00E-38//144aa//36%//NP—002573
    • TESTI20062180
    • TESTI20062580
    • TESTI20063330
    • TESTI20063410
    • TESTI20063600
    • TESTI20064370
    • TEST120064530//microtubule-associated protein like echinoderm EMAP [Homo sapiens].//1.00E-173//562aa//48%//XP—009139
    • TESTI20064650//Rattus norvegicus myr 6 myosin heavy chain mRNA, complete cds.//0//645aa//91%//U60416
    • TESTI20064990
    • TESTI20065650//INNER CENTROMERE PROTEIN (INCENP).//1.00E-14//273aa//27%//P53352
    • TESTI20066150
    • TESTI20066170
    • TESTI20066280
    • TESTI20066330//FIBRONECTIN PRECURSOR.//9.10E-12//408aa//22%//Q91740
    • TESTI20066590
    • TESTI20066650//CELL DIVISION CONTROL PROTEIN 25.//2.20E-18//216aa//32%//P04821
    • TESTI20067350
    • TESTI20067440//INTRACELLULAR PROTEIN TRANSPORT PROTEIN US01.//2.90E-11//553aa//20%//P25386
    • TESTI20067480//ZINC FINGER PROTEIN 184 (FRAGMENT).//8.60E-134//421 aa//50%//Q99676
    • TESTI20068530
    • TESTI20068790//TRANS-ACTING TRANSCRIPTIONAL PROTEIN ICP0 (P135 PROTEIN) (IER 2.9/ER2.6).//7.50E-06//240aa//28%//P29128
    • TESTI20068940
    • TESTI20070400//Homo sapiens CTL2 gene.//5.90E-229//694aa//55%//AJ245621
    • TEST120070740
    • TESTI20071130//MYOSIN HEAVY CHAIN, CARDIAC MUSCLE ALPHA ISOFORM.//6.30E-09//399aa//23%//Q02566
    • TESTI20071630//GLIOMA PATHOGENESIS-RELATED PROTEIN (RTVP-1 PROTEIN).//5.10E-44//203aa//42%//P48060
    • TESTI20073460
    • TESTI20075240//HYPOTHETICAL ZINC FINGER PROTEIN KIAA0961.//3.20E-145//492aa//56%//Q9Y2G7
    • TESTI20076570//Homo sapiens mitogen-activated protein kinase phosphatase x (MKPX) mRNA, complete cds.//7.20E-66//126aa//100%//AF165519
    • TESTI20076920
    • TESTI20079060
    • TESTI20079220//ZINC FINGER PROTEIN 29 (ZFP-29).//2.00E-73//281aa//49%//Q07230
    • TESTI20079980//SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1 (DISHEVELLED-1) (DSH HOMOLOG 1).//7.10E-212//413aa//93%//P51141
    • TESTI20080460
    • TESTI20081890//SPA-1 like protein p1294 [Rattus norvegicus]//5.80E-129//385aa//41%//AF026504
    • TESTI20083890
    • TESTI20084250//OXYSTEROL-BINDING PROTEIN.//3.70E-183//551aa//62%//P16258
    • TESTI20085670
    • TESTI20086840//CARTILAGE MATRIX PROTEIN PRECURSOR (MATRILIN-1).//3.40E-09//181aa//29%//P05099
    • TESTI20088840//ZINC-FINGER PROTEIN RFP (RET FINGER PROTEIN).//2.60E-73//258aa//31%//Q62158
    • TESTI20089290
    • TESTI20090180
    • TESTI20090970
    • TESTI20091360
    • TESTI20092170
    • TESTI20093900
    • TESTI20094620
    • TESTI20095200//HYPOTHETICAL 98.3 KDA PROTEIN B0495.7 IN CHROMOSOME II.//1.30E-63//328aa//40%//Q09216
    • TESTI20095440//probable membrane protein YOR240w—yeast (Saccharomyces cerevisiae)//1.00E-25//98aa//55%//S67133
    • TESTI20095770//NEDD1 PROTEIN (FRAGMENT).//5.80E-297//648aa//85%//P33215
    • TESTI20095880//HYPOTHETICAL SYMPORTER SLL1374.//3.80E-26//243aa//27%//P74168
    • TESTI20097270
    • TESTI20099350//MYOSIN HEAVY CHAIN, NONMUSCLE TYPE B (CELLULAR MYOSIN HEAVY CHAIN, TYPE B) (NMMHC-B).//1.50E-26//566aa//23%//P35580
    • TESTI20100090//Homo sapiens endocytic receptor Endo180 (ENDO180) mRNA, complete cds.//5.00E-161//317aa//93%//AF134838
    • TESTI20102390
    • TESTI20103690//Columba livia mRNA for 5′-nucleotidase.//2.70E-114//324aa//66%//AJ131243
    • TESTI20104090//TRANSCRIPTIONAL ENHANCER FACTOR TEF-4 (EMBRYONIC TEA DOMAIN-CONTAINING FACTOR) (ETF) (ETEF-1) (TEAD-2).//1.60E-228//450aa//92%//P48301
    • TESTI20105130//MYOTUBULARIN.//4.30E-95//537aa//38%//Q13496
    • TESTI20105910//AMILORIDE-SENSITIVE SODIUM CHANNEL DELTA-SUBUNIT (EPITHELIAL NA+ CHANNEL DELTA SUBUNIT) (DELTA ENAC) (NONVOLTAGE-GATED SODIUM CHANNEL 1 DELTA SUBUNIT) (SCNED) (DELTA NACH).//0//636aa//97%//P51172
    • TESTI20106170//Mus musculus spermatid WD-repeat protein mRNA, complete cds.//2.20E-167//367aa//83%//AF274321
    • TESTI20106820//PROTEIN KINASE C, ETA TYPE (EC 2.7.1.-) (NPKC-ETA) (PKC-L).//5.40E-53//97aa//100%//P24723
    • TESTI20107240//EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 10 (EIF-3 THETA) (EUKARYOTIC TRANSLATION INITIATION FACTOR 3 LARGE SUBUNIT) (PNLA-35).//5.60E-07//428aa//22%//Q40554
    • TESTI20107320//G1/S-SPECIFIC CYCLIN C-TYPE.//1.20E-05//130aa//26%//P93411
    • TESTI20107340
    • TESTI20108060//SERINE/THREONINE PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT (EC 3.1.3.16) (PP-1B).//1.10E-78//145aa//100%//P37140
    • TESTI20112540//CALDESMON (CDM).//9.10E-06//203aa//30%//P12957
    • TESTI20112860//MYOSIN LIGHT CHAIN KINASE (EC 2.7.1.117) (MLCK).//1.60E-54//290aa//40%//P25323
    • TESTI20113150
    • TESTI20113940
    • TESTI20114480//Human 1(3)mbt protein homolog mRNA, complete cds.//7.10E-146//582aa//49%//U89358
    • TESTI20116050
    • TESTI20116120//Aegilops squarrosa partial GAG56D gene for gamma-gliadin, accession CIae 24.//3.10E-07//93aa//40%//AJ389681
    • TESTI20117500
    • TESTI20118460
    • TESTI20120500
    • TESTI20120900
    • TESTI20121040//PROBABLE PROTEIN PHOSPHATASE 2C T23F11.1 (EC 3.1.3.16) (PP2C).//8.60E-13//91aa//39%//P49596
    • TESTI20121710//HYPOTHETICAL 57.5 KDA PROTEIN IN VMA7-RPS25A INTERGENIC REGION.//5.00E-08//292aa//26%//P53214
    • TESTI20122070//Xenopus laevis ER1 mRNA, complete cds.//1.80E-78//341aa//49%//AF015454
    • TESTI20122440
    • TESTI20124440
    • TESTI20125280//M-PROTEIN, STRIATED MUSCLE.//3.60E-68//295aa//46%//Q02173
    • TESTI20125440
    • TESTI20125920//G PROTEIN PATHWAY SUPPRESSOR 1 (GPS1 PROTEIN) (MFH PROTEIN).//5.20E-199//367aa//98%//Q13098
    • TESTI20126280//Mus musculus STAP mRNA for sperm tail associated protein, complete cds.//4.60E-213//769aa//57%//AB029919
    • TESTI20130530//INSULIN-DEGRADING ENZYME (EC 3.4.24.56) (INSULYSIN) (INSULINASE) (INSULIN PROTEASE).//1.60E-237//464aa//94%//P14735
    • TESTI20131440//CARBOXYPEPTIDASE A1 PRECURSOR (EC 3.4.17.1).//2.80E-107//332aa//58%//P15085
    • TESTI20132310
    • TESTI20132680
    • TESTI20134010
    • TESTI20134270
    • TESTI20134680//CENTROMERIC PROTEIN E (CENP-E PROTEIN).//2.40E-08//796aa//19%//Q02224
    • TESTI20134970//M. musculus Tenr mRNA for RNA binding protein.//5.50E-265//559aa//88%//X84693
    • TESTI20136010//MYOSIN HEAVY CHAIN, NONMUSCLE (CELLULAR MYOSIN HEAVY CHAIN) (NMMHC).//1.10E-11//438aa//23%//P14105
    • TESTI20140970//V_segment translation product [Homo sapiens].//6.30E-51//101aa//99%//AAC80210
    • TEST120142480
    • TESTI20142540//MPV17 PROTEIN.//8.00E-62//116aa//98%//P39210
    • TESTI20143180//CENTROMERIC PROTEIN E (CENP-E PROTEIN).//3.30E-09//507aa//22%//Q02224
    • TESTI20144390//TESTIS-SPECIFIC PROTEIN PBS13.//6.40E-76//251aa//63%//Q01755
    • TESTI20145780//Mus musculus mRNA for SH2-containing leukocyte protein 65.//1.20E-13//91aa//36%//Y17159
    • TESTI20148380//TRANSFORMATION-SENSITIVE PROTEIN IEF SSP 3521.//2.50E-05//193aa//22%//P31948
    • TESTI20149880
    • TESTI20150420//RHO-GTPASE-ACTIVATING PROTEIN 1 (GTPASE-ACTIVATING PROTEIN RHOGAP) (RHO-RELATED SMALL GTPASE PROTEIN ACTIVATOR) (CDC42 GTPASE-ACTIVATING PROTEIN) (P50-RHOGAP).//4.50E-09//129aa//34%//Q07960
    • TESTI20150920//PROTEIN PHOSPHATASES PP1 REGULATORY SUBUNIT SDS22.//2.60E-16//193aa//34%//P22194
    • TESTI20151050
    • TESTI20151800
    • TESTI20152490
    • TEST120153310//LAMIN B3.//6.30E-13//104aa//41%//P48680
    • TESTI20154370//HYALURONAN MEDIATED MOTILITY RECEPTOR (INTRACELLULAR HYALURONIC ACID BINDING PROTEIN) (RECEPTOR FOR HYALURONAN-MEDIATED MOTILITY).//1.10E-07//300aa//21%//075330
    • TESTI20159380
    • TESTI20161010
    • TESTI20162780//COTE1 PROTEIN.//1.00E-107//207aa//99%//P81408
    • TESTI20162980//DNA-DAMAGE INDUCIBLE PROTEIN DDI1.//1.80E-39//174aa//48%//P40087
    • TESTI20164210//PROTEIN KINASE C-BINDING PROTEIN NELL1 (NEL-LIKE PROTEIN 1) (FRAGMENT).//1.60E-88//163aa//92%//Q92832
    • TESTI20165680
    • TESTI20165990
    • TESTI20166290//Homo sapiens NY-REN-50 antigen mRNA, partial cds.//3.00E-223//426aa//93%//AF155112
    • TESTI20166670//HOMEOBOX PROTEIN HOX-B1 (HOX-2I).//6.70E-06//224aa//29%//P14653
    • TESTI20167580
    • TESTI20168880//BREAKPOINT CLUSTER REGION PROTEIN (EC 2.7.1.-).//2.10E-23//57aa//92%//P11274
    • TESTI20169500//HYPOTHETICAL 51.9 KDA PROTEIN C27F1.04C IN CHROMOSOME I.//9.50E-17//428aa//25%//Q10173
    • TESTI20170170//Homo sapiens mRNA for chondroitin-4-sulfotransferase (C4ST gene).//1.10E-53//277aa//40%//AJ269537
    • TESTI20170280
    • TESTI20170690
    • TESTI20170890
    • TESTI20171070//CYCLIC-AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-4 (DNA-BINDING PROTEIN TAXREB67) (CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN 2) (CREB2).//2.60E-63//136aa//91%//P18848
    • TESTI20173050
    • TESTI20173110
    • TESTI20173960//ZINC FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10) (HPF7).//1.90E-104//335aa//48%//Q05481
    • TESTI20175370//MYOSIN HEAVY CHAIN, NONMUSCLE (CELLULAR MYOSIN HEAVY CHAIN) (NMMHC).//1.00E-11//290aa//25%//P14105
    • TESTI20176450//thioredoxin interacting factor [Mus musculus].//1.00E-75//300aa//46%//AAG32665
    • TESTI20179230
    • TESTI20179510
    • TESTI20180600//Homo sapiens HOM-TES-85 tumor antigen mRNA, complete cds.//8.10E-106//202aa//99%//AF124430
    • TESTI20182210
    • TESTI20182760//AMILORIDE-SENSITIVE SODIUM CHANNEL DELTA-SUBUNIT (EPITHELIAL NA+ CHANNEL DELTA SUBUNIT) (DELTA ENAC) (NONVOLTAGE-GATED SODIUM CHANNEL 1 DELTA SUBUNIT) (SCNED) (DELTA NACH).//5.90E-185//336aa//99%//P51172
    • TESTI20183680//EARLY NODULIN 20 PRECURSOR (N-20).//5.10E-08//127aa//37%//P93329
    • TESTI20184280
    • TESTI20184750//LAMININ ALPHA-1 CHAIN PRECURSOR (LAMININ A CHAIN).//2.30E-200//377aa//99%//P25391
    • TESTI20184760//ZINC FINGER PROTEIN 29 (ZFP-29).//9.70E-74//281aa//49%//Q07230
    • TESTI20184820
    • TESTI20186110
    • TESTI20192570
    • TESTI20193080//GAR22 PROTEIN.//5.10E-153//313aa//92%//Q99501
    • TESTI20193520
    • TESTI20194880//PERIOD CIRCADIAN PROTEIN 1 (CIRCADIAN PACEMAKER PROTEIN RIGUI) (HPER).//1.50E-11//288aa//30%//05534
    • TESTI20196690//Bos taurus pyruvate dehydrogenase phosphatase regulatory subunit precursor, mRNA, complete cds.//9.10E-114//224aa//92%//AF026954
    • TESTI20196970//THIMET OLIGOPEPTIDASE (EC 3.4.24.15) (ENDOPEPTIDASE 24.15) (MP78).//4.00E-106//147aa//100%//P52888
    • TESTI20197030
    • TESTI20197290
    • TESTI20197600//TRANSCRIPTIONAL REPRESSOR CTCF.//5.30E-120//271aa//82%//P49711
    • TESTI20198540
    • TESTI20198600
    • TESTI20199110//disintegrin-like testicular metalloproteinase (EC 3.4.24.-) IVb—crab-eating macaque (fragment)//1.00E-167//331aa//84%//165253
    • TESTI20199980
    • TESTI20200120
    • TESTI20200840
    • TESTI20201760//SYNAPTONEMAL COMPLEX PROTEIN 1 (SCP-1 PROTEIN).//4.70E-09//189aa//25%//Q15431
    • TESTI20202830
    • TESTI20204260
    • TESTI20205100//TRICHOHYALIN.//2.60E-15//343aa//24%//P37709
    • TESTI20205150
    • TESTI20205250//phosphatidylinositol-4-phosphate 5-kinase homolog T3K9.2—Arabidopsis thaliana//4.20E-21//194aa//33%//T02098
    • TESTI20207170//Human testis-specific protein (TSPY) mRNA, complete cds.//6.60E-111//231aa//96%//U58096
    • TESTI20209050//HYPOTHETICAL 113.1 KDA PROTEIN IN PRE5-FET4 INTERGENIC REGION.//1.90E-05//462aa//22%//Q04893
    • TESTI20210030
    • TESTI20210570//RETINAL-BINDING PROTEIN (RALBP).//5.00E-53//327aa//36%//P49193
    • TESTI20211380
    • TESTI20212970//PUTATIVE ATP-DEPENDENT RNA HELICASE YIR002C.//5.90E-85//458aa//32%//P40562
    • TESTI20214630
    • TESTI20215310//Homo sapiens calcyclin binding protein mRNA, complete cds.//6.60E-95//182aa//100%//AF057356
    • TESTI20219110//TYROSINE-PROTEIN KINASE-LIKE 7 PRECURSOR(COLON CARCINOMA KINASE-4) (CCK-4).//4.00E-23//53aa//100%//Q13308
    • TESTI20219390
    • TESTI20220230//Bos taurus Reissner's fiber glycoprotein I mRNA, partial cds.//1.20E-10//77aa//50%//AF078930
    • TESTI20221790
    • TESTI20222030//Homo sapiens very long-chain acyl-CoA synthetase (BG1) mRNA, complete cds.//6.10E-172//643aa//50%//AF179481
    • TESTI20222460//DYNEIN GAMMA CHAIN, FLAGELLAR OUTER ARM.//1.50E-138//589aa//46%//Q39575
    • TESTI20223380
    • TESTI20226520//TUBULIN-TYROSINE LIGASE (EC 6.3.2.25) (TTL).//6.70E-06//164aa//30%//P38160
    • TEST120227380//DEAD BOX PROTEIN 4 (VASA HOMOLOG) (RVLG).//1.10E-263//577aa//86%//Q64060
    • TESTI20228120//RHO-GTPASE-ACTIVATING PROTEIN 6 (RHO-TYPE GTPASE-ACTIVATING PROTEIN RHOGAPX-1) (FRAGMENT).//4.50E-12//164aa//34%//054834
    • TESTI20228740//ZINC FINGER PROTEIN 135.//3.50E-25//132aa//43%//P52742
    • TESTI20244220//MYOSIN HEAVY CHAIN IB (MYOSIN HEAVY CHAIN IL).//6.50E-11//77aa//42%//P19706
    • TESTI20244430//ANKYRIN 1 (ERYTHROCYTE ANKYRIN) (ANKYRIN R) (ANKYRINS 2.1 AND 2.2).//3.70E-15//173aa//35%//P16157
    • TESTI20244460//ADENYLATE KINASE, CHLOROPLAST (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE).//3.60E-34//209aa//37%//P43188
    • TESTI20244730//Mus musculus alpha/beta hydrolase-1 mRNA, complete cds.//8.20E-113//266aa//81%//AF189764
    • TESTI20245600//HYPOTHETICAL 118.4 KDA PROTEIN IN BAT2-DAL5 INTERGENIC REGION PRECURSOR.//4.50E-05//236aa//27%//P47179
    • TESTI20245860
    • TESTI20246410
    • TESTI20246480//Homo sapiens germline specific RNA binding protein (DAZL1) mRNA, complete cds.//5.00E-22//86aa//55%//U66726
    • TESTI20247440//Human BLu protein testis isoform (BLu) mRNA, complete cds.//5.40E-45//91aa//96%//U70880
    • TESTI20248850
    • TESTI20249360//Homo sapiens DEME-6 mRNA, partial cds.//4.70E-94//299aa//56%//AF007170
    • TESTI20250220//TRICHOHYALIN.//5.40E-54//537aa//30%//P37709
    • TESTI20250630//Columba livia mRNA for 5′-nucleotidase.//3.80E-115//328aa//66%//AJ131243
    • TESTI20251440//Rattus norvegicus (rsec6) mRNA, complete cds.//3.80E-31//379aa//28%//U32575
    • TESTI20251610//INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2 PRECURSOR (ITI HEAVY CHAIN H2).//1.10E-07//182aa//26%//002668
    • TESTI20251740//FYN-BINDING PROTEIN (SLP-76 ASSOCIATED PROTEIN) (SLAP-130).//6.30E-16//88aa//50%//015117
    • TESTI20252690//SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3 (DISHEVELLED-3) (DSH HOMOLOG 3) (KIAA0208).//4.60E-137//304aa//85%//Q92997
    • TESTI20254030//Homo sapiens actin-binding double-zinc-finger protein (abLIM) mRNA, complete cds.//6.70E-150//280aa//96%//AF005654
    • TESTI20254090
    • TESTI20254480
    • TESTI20254990//ZINC FINGER PROTEIN GLI3 (NEURAL SPECIFIC DNA BINDING PROTEIN XGLI3) (XGLI-3).//6.50E-46//105aa//75%//Q91660
    • TESTI20255460//Mus musculus mRNA for MIWI (piwi), complete cds.//1.50E-225//864aa//49%//AB032604
    • TESTI20256560//NUF1 PROTEIN (SPINDLE POLY BODY SPACER PROTEIN SPC110).//5.70E-05//590aa//19%//P32380
    • TESTI20257910//HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN G PRECURSOR (HLA G ANTIGEN).//1.90E-122//223aa//100%//P17693
    • TESTI20258720//ANKYRIN 1 (ERYTHROCYTE ANKYRIN) (ANKYRIN R) (ANKYRINS 2.1 AND 2.2).//1.20E-10//233aa//27%//P16157
    • TEST120259110
    • TESTI20259200
    • TESTI20260140
    • TESTI20260640//helicase II homolog—fruit fly (Drosophila sp.)//2.70E-27//374aa//27%//T13889
    • TESTI20261040//DPY-19 PROTEIN.//2.10E-47//316aa//34%//P34413
    • TESTI20261160//Mus musculus rasGAP-activating-like protein mRNA, complete cds.//1.60E-21//129aa//41%//AF086714
    • TESTI20261680//HEAT SHOCK PROTEIN 30C.//1.70E-08//136aa//27%//P30218
    • TESTI20262150//Rattus norvegicus mRNA for voltage-gated ca channel, complete cds.//0//822aa//87%//AB018253
    • TESTI20262940//TUBULIN-TYROSINE LIGASE (EC 6.3.2.25) (TTL).//5.70E-10//218aa//25%//P38160
    • TESTI20264530//PUTATIVE SERINE/THREONINE-PROTEIN KINASE PKWA (EC 2.7.1.-).//5.60E-18//219aa//34%//P49695
    • TESTI20264910
    • TEST120265150
    • TESTI20265340
    • TESTI20265890
    • TESTI20266050//52 KDA RO PROTEIN (SJOGREN SYNDROME TYPE A ANTIGEN (SS-A)) (RO(SS-A)).//2.10E-77//472aa//38%//P19474
    • TESTI20268240//Homo sapiens membrane-associated nucleic acid binding protein mRNA, partial cds.//1.90E-52//412aa//36%//AF255303
    • TESTI20269250
    • TESTI20269360
    • TESTI20270130//FIBRILLARIN.//2.10E-11//97aa//43%//Q22053
    • TESTI20271790//Human p76 mRNA, complete cds.//6.9e-317//496aa//99%//U81006
    • TESTI20272380
    • TESTI20274960//ZINC FINGER PROTEIN 83 (ZINC FINGER PROTEIN HPF1).//7.90E-126//342aa//63%//P51522
    • TESTI20277300
    • TESTI20278280//Mus musculus p53 apoptosis-associated target (Perp) mRNA, complete cds.//3.40E-84//155aa//88%//AF249870
    • TESTI20282420//Mus musculus EPCS26 mRNA, complete cds.//2.40E-19//122aa//33%//AF250838
    • TESTI20282530//ZINC FINGER PROTEIN 135.//1.60E-56//271aa//39%//P52742
    • TESTI20282900
    • TESTI20284260//HISTONE H2B F (H2B 291A).//2.10E-22//120aa//43%//P10853
    • TESTI20285230//DOUBLE-STRANDED RNA-SPECIFIC EDITASE 1 (EC 3.5.-.-) (DSRNA ADENOSINE DEAMINASE) (RNA EDITING ENZYME 1).//2.10E-20//192aa//38%//P51400
    • TESTI20286590//Human type 3 inositol 1,4,5-trisphosphate receptor (ITPR3) mRNA, complete cds.//1.00E-93//185aa//100%//U01062
    • TESTI20287760
    • THYMU10004280//ZINC-FINGER PROTEIN HT2A (72 KDA TAT-INTERACTING PROTEIN).//7.90E-13//87aa//42%//Q13049
    • THYMU20006020//ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL PRECURSOR (EC 1.1.1.41) (ISOCITRIC DEHYDROGENASE) (NAD+-SPECIFIC ICDH).//2.60E-120//229aa//99%//P50213
    • THYMU20007020
    • THYMU20007750
    • THYMU20008000
    • THYMU20009460
    • THYMU20009500
    • THYMU20009710
    • THYMU20010180//MOB1 PROTEIN (MPS1 BINDER 1).//2.60E-31//136aa//50%//P40484
    • THYMU20010710
    • THYMU20012020
    • THYMU20012560
    • THYMU20013250//LIM DOMAIN KINASE 2 (EC 2.7.1.-) (LIMK-2).//3.50E-213//354aa//99%//P53671
    • THYMU20013810//Human SEC7 homolog Tic (TIC) mRNA, complete cds.//2.30E-88//138aa//96%//U63127
    • THYMU20014430
    • THYMU20017270
    • THYMU20018250
    • THYMU20018390
    • THYMU20019000
    • THYMU20019260//ZINC FINGER PROTEIN 85 (ZINC FINGER PROTEIN HPF4) (HTF1).//6.80E-49//137aa//68%//Q03923
    • THYMU20020370
    • THYMU20020800//LMBR1 long form [Mus musculus].//3.00E-69//198aa//55%//AAF91092
    • THYMU20021090//Homo sapiens Sex comb on midleg homolog 1 isoform 1 (SCMH1) mRNA, complete cds.//4.40E-80//149aa//63%//AF149045
    • THYMU20021540
    • THYMU20023560//DNA BINDING PROTEIN RFX2.//6.70E-25//59aa//94%//P48378
    • THYMU20024500//NEUROFILAMENT TRIPLET M PROTEIN (160 KDA NEUROFILAMENT PROTEIN) (NF-M).//6.20E-06//296aa//22%//P16053
    • THYMU20025480
    • THYMU20026950//Mus musculus ROSA 26 transcription AS ROSA26AS mRNA, complete cds.//2.20E-12//285aa//23%//U83176
    • THYMU20028150//AXONIN-1 PRECURSOR (AXONAL GLYCOPROTEIN TAG-1) (TRANSIENT AXONAL GLYCOPROTEIN 1).//2.20E-33//301aa//31%//Q02246
    • THYMU20028410//Mus musculus Pax transcription activation domain interacting protein PTIP mRNA, complete cds.//1.70E-144//345aa//81%//AF104261
    • THYMU20029830
    • THYMU20030460//Homo sapiens tumor endothelial marker 7 precursor (TEM7) mRNA, complete cds.//2.10E-123//230aa//99%//AF279144
    • THYMU20030690
    • THYMU20031330//Homo sapiens putative nucleotide binding protein mRNA, complete cds.//1.00E-18//64aa//82%//AF118394
    • THYMU20032820//ZINC FINGER PROTEIN 135.//1.40E-82//258aa//55%//P52742
    • THYMU20034400//26S proteasome subunit p44.5 [Homo sapiens]//8.80E-29//71aa//91%//AB003102
    • THYMU20034790
    • THYMU20036500
    • THYMU20039320//PUTATIVE SERINE/THREONINE-PROTEIN KINASE PKWA (EC 2.7.1.-).//1.40E-09//206aa//27%//P49695
    • THYMU20043440
    • THYMU20043560
    • THYMU20044100
    • THYMU20044520
    • THYMU20046350
    • THYMU20046770
    • THYMU20049060//SPLICING FACTOR, ARGININE/SERINE-RICH 2 (SPLICING FACTOR SC35) (SC-35) (SPLICING COMPONENT, 35 KDA) (PR264 PROTEIN).//6.00E-41//119aa//76%//P30352
    • THYMU20050010
    • THYMU20051340
    • THYMU20052460//PHORBOLIN I (FRAGMENTS).//5.80E-20//111aa//45%//P31941
    • THYMU20052830//Homo sapiens mRNA for immunoglobulin lambda heavy chain.//1.50E-237//477aa//90%//Y14737
    • THYMU20054800
    • THYMU20055450
    • THYMU20055460//ESTERASE D (EC 3.1.1.1).//7.60E-57//107aa//100%//P10768
    • THYMU20055740
    • THYMU20055760//Mus musculus group IIF secreted phospholipase A2 (Pla2g2f) mRNA, complete cds.//1.70E-73//165aa//75%//AF166099
    • THYMU20058550
    • THYMU20060480
    • THYMU20062520
    • THYMU20062610//DYNEIN GAMMA CHAIN, FLAGELLAR OUTER ARM.//1.70E-156//585aa//50%//Q39575
    • THYMU20062770//UROMODULIN PRECURSOR (TAMM-HORSFALL URINARY GLYCOPROTEIN) (THP).//4.20E-22//253aa//28%//P27590
    • THYMU20063650//Homo sapiens mRNA for putative ribulose-5-phosphate-epimerase, partial cds.//9.30E-57//116aa//97%//AJ224326
    • THYMU20064680
    • THYMU20066660//Homo sapiens putative ATP-dependent RNA helicase ROK1 mRNA, complete cds.//9.20E-153//361aa//85%//AF077033
    • THYMU20069130
    • THYMU20069460
    • THYMU20069650
    • THYMU20070250//TRANSKETOLASE (EC 2.2.1.1) (TK).//4.50E-288//513aa//96%//P29401
    • THYMU20071120//ZINC FINGER PROTEIN 85 (ZINC FINGER PROTEIN HPF4) (HTF1).//1.40E-229//536aa//74%//Q03923
    • THYMU20071460
    • THYMU20072580
    • THYMU20073070
    • THYMU20073080
    • THYMU20077250//T-CELL-SPECIFIC TRANSCRIPTION FACTOR 1 (TCF-1) (T-CELL FACTOR 1) (TRANSCRIPTION FACTOR-7).//4.10E-90//176aa//96%//Q00417
    • THYMU20078020
    • THYMU20078240
    • THYMU20079690
    • THYMU20080490
    • THYMU20081110//PINCH PROTEIN (PARTICULARY INTERESTING NEW CYS-HIS PROTEIN).//4.00E-28//60aa//86%//P48059
    • THYMU20083390
    • THYMU20083500
    • THYMU20083830//Homo sapiens angiostatin binding protein 1 mRNA, complete cds.//2.30E-09//230aa//28%//AF286598
    • THYMU20084520
    • THYMU20086430
    • THYMU20087270//POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE IIB (EC 3.6.1.-).//7.20E-154//235aa//88%//P98195
    • THYMU20089170
    • THYMU20089900
    • THYMU20090230//Homo sapiens ribonucleoprotein mRNA, complete cds.//9.30E-73//133aa//100%//L32610
    • THYMU20091040
    • THYMU20095920//Homo sapiens nuclear prelamin A recognition factor mRNA, complete cds.//2.90E-94//178aa//100%//AF128406
    • THYMU20096580//SERYL-TRNA SYNTHETASE (EC 6.1.1.11) (SERINE-TRNA LIGASE) (SERRS).//9.90E-20//45aa//97%//P49591
    • THYMU20097920//mitogen inducible gene mig-2—human//2.50E-197//477aa//55%//S69890
    • THYMU20098350//KERATIN, TYPE II CYTOSKELETAL 5 (CYTOKERATIN 5) (K5) (CK 5) (58 KDA CYTOKERATIN).//3.40E-267//577aa//89%//P13647
    • THYMU20099060//IG ALPHA-1 CHAIN C REGION.//1.70E-196//353aa//99%//P01876
    • THYMU20100940//POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE IR (EC 3.6.1.-) (FRAGMENT).//0//646aa//99%//Q9Y2G3
    • THYMU20104480//TRICHOHYALIN.//2.90E-21//300aa//28%//P37709
    • THYMU20106990//Mus musculus evectin-2 (Evt2) mRNA, complete cds.//2.20E-112//222aa//90%//AF189817
    • THYMU20110720//PROBABLE AMINOTRANSFERASE T01B11.2 (EC 2.6.1.-).//6.90E-40//211aa//41%//P91408
    • THYMU20112570
    • THYMU20112590//Homo sapiens AP-4 adaptor complex beta4 subunit mRNA, complete cds.//3.40E-306//534aa//99%//AF092094
    • THYMU20115380
    • THYMU20115730
    • THYMU20117850
    • THYMU20120240//Arabidopsis thaliana ubiquitin-specific protease (AtUBP4) mRNA, complete cds.//4.10E-18//179aa//28%//U76846
    • THYMU20120730//ALDEHYDE DEHYDROGENASE, DIMERIC NADP-PREFERRING (EC 1.2.1.5) (ALDH CLASS 3).//2.10E-203//379aa//99%//P30838
    • THYMU20121040//ELONGATION FACTOR 1-DELTA (EF-1-DELTA).//5.30E-149//281 aa//99%//P29692
    • THYMU20128910
    • THYMU20129020
    • THYMU20130470
    • THYMU20134260
    • THYMU20137050
    • THYMU20137570
    • THYMU20139160
    • THYMU20140510
    • THYMU20143230//Homo sapiens mRNA for stabilin-1 (stab1 gene).//1.70E-177//317aa//99%//AJ275213
    • THYMU20145990//nesca protein [Homo sapiens].//1.90E-152//282aa//98%//NP—055143
    • THYMU20148010
    • THYMU20149230
    • THYMU20150190
    • THYMU20151610//Homo sapiens antigen NY-CO-1 (NY-CO-1) mRNA, complete cds.//1.40E-181//344aa//100%//AF039687
    • THYMU20153210//Homo sapiens Diff33 protein homolog mRNA, complete cds.//4.00E-120//404aa//54%//AF164794
    • THYMU20154790
    • THYMU20157620
    • THYMU20163600
    • THYMU20170080//Homo sapiens SIT protein.//9.50E-48//78aa//98%//AJ010059
    • THYMU20170230//Homo sapiens sarcosine dehydrogenase (SARDH) mRNA, complete cds.//1.80E-183//260aa//99%//AF095735
    • THYMU20171580
    • THYMU20174490
    • THYMU20174790
    • THYMU20175260
    • THYMU20176010//VEGETATIBLE INCOMPATIBILITY PROTEIN HET-E-1.//1.80E-20//256aa//28%//Q00808
    • THYMU20177070
    • THYMU20178440//Homo sapiens mRNA for immunoglobulin lambda heavy chain.//2.20E-229//479aa//88%//Y14737
    • THYMU20181890
    • THYMU20184550
    • THYMU20185470
    • THYMU20185650//DIAPHANOUS PROTEIN HOMOLOG 1.//1.30E-20//85aa//44%//060610
    • THYMU20187210
    • THYMU20191970//Homo sapiens FLAMINGO 1 mRNA, partial cds.//1.80E-54//450aa//36%//AF234887
    • TKIDN10000620//Homo sapiens Tax interaction protein 2 mRNA, partial cds.//1.20E-56//114aa//100%//AF028824
    • TKIDN10001710
    • TKIDN10001920//ZINC FINGER PROTEIN 85 (ZINC FINGER PROTEIN HPF4) (HTF1).//3.20E-97//226aa//73%//Q03923
    • TRACH20011010//GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3) (GLUCAN 1,4-ALPHA-GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN GLUCOHYDROLASE).//4.30E-17//593aa//22%//P08640
    • TRACH20011540//TUMOR-ASSOCIATED ANTIGEN L6.//4.70E-57//113aa//97%//P30408
    • TRACH20012490
    • TRACH20021000
    • TRACH20021380//ADENYLATE CYCLASE, TYPE V (EC 4.6.1.1) (ATP PYROPHOSPHATE-LYASE) (CA(2+)-INHIBITABLE ADENYLYL CYCLASE).//1.20E-276//492aa//95%//P30803
    • TRACH20025370
    • TRACH20026640
    • TRACH20029880
    • TRACH20040390//MATERNAL PUMILIO PROTEIN.//1.20E-177//812aa//47%//P25822
    • TRACH20041090
    • TRACH20043360//PUTATIVE KINESIN-LIKE PROTEIN C2F12.13.//2.30E-55//333aa//39%//014343
    • TRACH20044990
    • TRACH20049500
    • TRACH20051590
    • TRACH20057200
    • TRACH20058000
    • TRACH20073990
    • TRACH20080810
    • TRACH20081270
    • TRACH20090060//SYNAPTOTAGMIN IV.//1.10E-12//301aa//25%//P40749
    • TRACH20091070//ALDEHYDE DEHYDROGENASE, DIMERIC NADP-PREFERRING (EC 1.2.1.5) (ALDH CLASS 3).//1.00E-173//328aa//98%//P30838
    • TRACH20093400//TRICHOHYALIN.//2.30E-13//701aa//20%//P37709
    • TRACH20093480
    • TRACH20098510//MYOSIN HEAVY CHAIN, GIZZARD SMOOTH MUSCLE.//1.10E-20//640aa//21%//P10587
    • TRACH20101590
    • TRACH20104510
    • TRACH20108240//ribonucleoprotein—African clawed frog//4.10E-118//223aa//96%//S40774
    • TRACH20113020//SELENIDE, WATER DIKINASE 2 (EC 2.7.9.3) (SELENOPHOSPHATE SYNTHETASE 2) (SELENIUM DONOR PROTEIN 2).//1.80E-207//364aa//96%//Q99611
    • TRACH20122980//HYPOTHETICAL PROTEIN MJ0798.//6.80E-13//211aa//22%//Q58208
    • TRACH20123870
    • TRACH20124970
    • TRACH20125620
    • TRACH20129180
    • TRACH20131230//Homo sapiens oxysterol binding protein-related protein 3 (ORP3) mRNA, complete cds.//7.50E-282//608aa//62%//AY008372
    • TRACH20139280
    • TRACH20140180
    • TRACH20143710//RAB GERANYLGERANYLTRANSFERASE ALPHA SUBUNIT (EC 2.5.1.-) (RAB GERANYL-GERANYLTRANSFERASE ALPHA SUBUNIT) (RAB GG TRANSFERASE) (RAB GGTASE).//9.70E-07//142aa//33%//Q92696
    • TRACH20149500//KERATIN, TYPE I CUTICULAR HA6 (HAIR KERATIN, TYPE I HA6).//1.10E-62//215aa//60%//076013
    • TRACH20149720
    • TRACH20149740//EXCITATORY AMINO ACID TRANSPORTER 5 (RETINAL GLUTAMATE TRANSPORTER).//5.00E-76//152aa//98%//000341
    • TRACH20158240
    • TRACH20159390
    • TRACH20160800
    • TRACH20163470//Mus musculus putative thymic stromal co-transporter TSCOT mRNA, complete cds.//3.20E-41//187aa//34%//AF148145
    • TRACH20164100//RETROVIRUS-RELATED PROTEASE (EC 3.4.23.-).//1.40E-32//113aa//56%//P10265
    • TRACH20164810
    • TRACH20165330
    • TRACH20165540//Human alpha-1 type I collagen gene surrounding osteogenesis imperfecta OI type II deletion.//4.00E-05//102aa//37%//M11162
    • TRACH20167090
    • TRACH20170860//IG DELTA CHAIN C REGION.//1.60E-212//383aa//100%//P01880
    • TRACH20173680//Homo sapiens mRNA for LAK-4p, complete cds.//3.50E-80//410aa//38%//AB002405
    • TRACH20174980
    • TRACH20182780
    • TRACH20185120
    • TRACH20188350//Homo sapiens mRNA for centaurin beta2.//3.80E-60//204aa//56%//AJ238248
    • TRACH20190460//MONO- AND DIACYLGLYCEROL LIPASE PRECURSOR (EC 3.1.1.-) (MDGL).//2.60E-11//195aa//28%//P25234
    • UMVEN10001380
    • UTERU10001060//ETS-DOMAIN PROTEIN ELK-1.//1.40E-39//88aa//93%//P19419
    • UTERU10001870
    • UTERU20000230
    • UTERU20000950//Homo sapiens PC326 protein (PC326) mRNA, complete cds.//2.80E-55//112aa//100%//AF150734
    • UTERU20011760
    • UTERU20013890
    • UTERU20016580//POTENTIAL TRANSCRIPTIONAL ADAPTOR.//1.90E-37//323aa//31%//Q02336
    • UTERU20026620//ZINC FINGER PROTEIN 75.//7.50E-82//174aa//82%//P51815
    • UTERU20027360
    • UTERU20029930
    • UTERU20031350
    • UTERU20035770
    • UTERU20040150
    • UTERU20040370
    • UTERU20040390
    • UTERU20040730
    • UTERU20041630//ZINC FINGER PROTEIN 184 (FRAGMENT).//3.30E-75//239aa//44%//Q99676
    • UTERU20041970
    • UTERU20045200
    • UTERU20051790//guanylate kinase-interacting protein 1 Maguin-1, membrane-associated—rat//8.20E-26//267aa//33%//T18293
    • UTERU20064120//MYELOID UPREGULATED PROTEIN.//1.30E-79//245aa//66%//035682
    • UTERU20065470
    • UTERU20079240
    • UTERU20083020
    • UTERU20086530//GLYCODELIN PRECURSOR (GD) (PREGNANCY-ASSOCIATED ENDOMETRIAL ALPHA-2 GLOBULIN) (PEG) (PAEG) (PLACENTAL PROTEIN 14) (PROGESTERONE-ASSOCIATED ENDOMETRIAL PROTEIN) (PROGESTAGEN-ASSOCIATED ENDOMETRIAL PROTEIN).//6.00E-73//140aa//99%//P09466
    • UTERU20087070//COMPLEMENT C1R COMPONENT PRECURSOR (EC 3.4.21.41).//4.80E-206//360aa//99%//P00736
    • UTERU20087850//Homo sapiens mRNA for mucolipidin (ML4 gene).//2.70E-34//184aa//42%//AJ293970
    • UTERU20089300
    • UTERU20089390//Plectonema boryanum kinesin light chain (KLC) gene, complete cds.//3.30E-38//216aa//43%//U78597
    • UTERU20089620//Homo sapiens radical fringe (RFNG) gene, partial cds.//1.50E-31//65aa//100%//AF108139
    • UTERU20090940
    • UTERU20091470
    • UTERU20094830//SINGLE-MINDED HOMOLOG 2 (SIM TRANSCRIPTION FACTOR) (MSIM).//8.70E-09//427aa//25%//Q61079
    • UTERU20095100
    • UTERU20099040//ZINC TRANSPORTER 2 (ZNT-2).//9.80E-96//242aa//76%//Q62941
    • UTERU20099510//ZINC FINGER PROTEIN 135.//2.20E-107//346aa//54%//P52742
    • UTERU20101150//NUCLEAR FACTOR NF-KAPPA-B P49 SUBUNIT.//2.20E-07//76aa//47%//Q04860
    • UTERU20102260
    • UTERU20103040
    • UTERU20103200
    • UTERU20104310//DNA-DIRECTED RNA POLYMERASE II 14.4 KDA POLYPEPTIDE (EC 2.7.7.6) (RPB6) (RPB14.4).//1.80E-48//97aa//100%//P41584
    • UTERU20106510
    • UTERU20121140
    • UTERU20122520//MOESIN (MEMBRANE-ORGANIZING EXTENSION SPIKE PROTEIN).//6.00E-37//399aa//28%//P26042
    • UTERU20125810
    • UTERU20127030//LAMININ BETA-2 CHAIN PRECURSOR(S-LAMININ).//6.80E-175//377aa//92%//P55268
    • UTERU20127150
    • UTERU20128560//26.4 KDA PROTEIN IN RUVC-ASPS INTERGENIC REGION.//2.60E-17//120aa//34%//P24237
    • UTERU20132620//AXONEME-ASSOCIATED PROTEIN MST101 (2).//1.40E-15//231aa//31%//Q08696
    • UTERU20134830//pellino (Drosophila) homolog 2 [Homo sapiens]//1.40E-153//361aa//72%//NP—067078
    • UTERU20139760//solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34 kD), member 17 [Homo sapiens]//5.40E-100//203aa//97%//XP—001136
    • UTERU20140010
    • UTERU20167570
    • UTERU20168960//Homo sapiens actin filament associated protein (AFAP) mRNA, complete cds.//2.60E-68//364aa//43%//AF188700
    • UTERU20169020//HOMEOBOX PROSPERO-LIKE PROTEIN PROX1 (PROX 1).//1.30E-54//117aa//74%//Q91018
    • UTERU20173030
    • UTERU20176230
    • UTERU20177150//Homo sapiens zinc finger protein dp mRNA, complete cds.//4.60E-10//104aa//40%//AF153201
    • UTERU20181270
    • UTERU20185220//Human mRNA for transcriptional activator hSNF2a, complete cds.//1.60E-125//246aa//98%//D26155
    • UTERU20188670//HFM1 PROTEIN.//5.10E-19//234aa//26%//P51979
    • UTERU20188840

Claims (5)

1. (canceled)
2. A polypeptide encoded by a polynucleotide selected from the group consisting of the following (a) to (g):
(a) a polynucleotide comprising a protein-coding region of the nucleotide sequence of any one of SEQ ID NOs: 1 to 1970:
(b) a polynucleotide encoding a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs: 1971 to 3940:
(c) a polynucleotide comprising a nucleotide sequence encoding a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs: 1971 to 3940, wherein in said amino acid sequence, one or more amino acids have been substituted, deleted, inserted and/or added, and wherein said nucleotide sequence encodes a polypeptide functionally equivalent to a polypeptide comprising the selected amino acid sequence;
(d) a polynucleotide hybridizing to a polynucleotide comprising the nucleotide sequence of any one of SEQ ID NOs: 1 to 1970, wherein said nucleotide sequence encodes a polypeptide functionally equivalent to a polypeptide encoded by the selected nucleotide sequence;
(e) a polynucleotide comprising a nucleotide sequence encoding a partial amino acid sequence of a polypeptide encoded by the polynucleotide according to any one of (a) to (d);
(f) a polynucleotide comprising a nucleotide sequence having at least 70% identity to the nucleotide sequence of any one of SEQ ID NOs: 1 to 1970; and
(g) a polynucleotide comprising a nucleotide sequence having at least 90% identity to the nucleotide sequence of any one of SEQ ID NOs: 1 to 1970, or a partial peptide thereof.
3-7. (canceled)
8. A method for producing the polypeptide or the partial peptide of claim 2, said method comprising the steps of culturing a transformant carrying a polynucleotide selected from the group consisting of the following (a) to (g):
(a) a polynucleotide comprising a protein-coding region of the nucleotide sequence of any one of SEQ ID NOs: 1 to 1970;
(b) a polynucleotide encoding a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs: 1971 to 3940;
(c) a polynucleotide comprising a nucleotide sequence encoding a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs: 1971 to 3940, wherein, in said amino acid sequence, one or more amino acids have been substituted, deleted, inserted and/or added, and wherein said nucleotide sequence encodes a polypeptide functionally equivalent to a polypeptide comprising the selected amino acid sequence;
(d) a polynucleotide hybridizing to a polynucleotide comprising the nucleotide sequence of any one of SEQ ID NOs: 1 to 1970, wherein said nucleotide sequence encodes a polypeptide functionally equivalent to a polypeptide encoded by the selected nucleotide sequence;
(e) a polynucleotide comprising a nucleotide sequence encoding a partial amino acid sequence of a polypeptide encoded by the polynucleotide according to any one of (a) to (d);
(f) a polynucleotide comprising a nucleotide sequence having at least 70% identity to the nucleotide sequence of any one of SEQ ID NOs: 1 to 1970; and
(g) a polynucleotide comprising a nucleotide sequence having at least 90% identity to the nucleotide sequence of any one of SEQ ID NOs: 1 to 1970, and recovering an expression product.
9-14. (canceled)
US11/072,512 2001-11-05 2005-03-07 Novel full length cDNA Abandoned US20060029945A1 (en)

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US11/072,512 US20060029945A1 (en) 2001-11-05 2005-03-07 Novel full length cDNA

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JP2001-379298 2001-11-05
JP2001379298A JP2003135075A (en) 2001-11-05 2001-11-05 NEW FULL-LENGTH cDNA
US35097802P 2002-01-25 2002-01-25
US10/104,047 US6943241B2 (en) 2001-11-05 2002-03-25 Full-length cDNA
US11/072,512 US20060029945A1 (en) 2001-11-05 2005-03-07 Novel full length cDNA

Related Parent Applications (1)

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US11/072,512 Abandoned US20060029945A1 (en) 2001-11-05 2005-03-07 Novel full length cDNA

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