US20050032806A1 - Method for treating anhedonia using dopamine agonists - Google Patents
Method for treating anhedonia using dopamine agonists Download PDFInfo
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- US20050032806A1 US20050032806A1 US10/941,524 US94152404A US2005032806A1 US 20050032806 A1 US20050032806 A1 US 20050032806A1 US 94152404 A US94152404 A US 94152404A US 2005032806 A1 US2005032806 A1 US 2005032806A1
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- Prior art keywords
- pramipexole
- dopamine agonist
- anhedonia
- enantiomer
- acid addition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the invention relates to the use of dopamine agonists for preparing a pharmaceutical composition for overcoming and/or alleviating anhedonia.
- anhedonia is used in the prior art to denote a series of symptomatic conditions.
- anhedonia is used, for example, to denote loss of pleasure in life as well as an inability to derive any enjoyment from experiences or stimulations which normally give pleasure.
- anhedonia is divided into social anhedonia (for example, the loss of pleasure in being with friends) and psychic anhedonia (for example, the loss of pleasure in observing the beauty of nature).
- social anhedonia for example, the loss of pleasure in being with friends
- psychic anhedonia for example, the loss of pleasure in observing the beauty of nature.
- a symptom anhedonia is found in psychiatric clinical pictures such as severe depression, schizophrenia, and dependency diseases. It may possibly also occur as a result of serious stress and extreme situations.
- dopamine agonists may usefully be used in therapeutically effective doses to overcome and/or alleviate anhedonia.
- the present invention relates to the use of dopamine agonists for preparing a pharmaceutical composition for overcoming and/or alleviating anhedonia.
- the present invention relates to the use of dopamine agonists for preparing a pharmaceutical composition for overcoming and/or alleviating anhedonia in diseases of dependency.
- dependency diseases are meant within the scope of the present invention diseases or disorders of the state of health, which result from the physical and/or psychological dependency of an individual on drugs and/or medication, for example.
- Dependency on medication may arise, for example, as a result of regularly taking active substances, such as opiates, for example.
- Drug dependency may arise, for example, as a result of regularly taking heroin, cocaine, marijuana, and the like.
- drug dependency is also meant within the scope of the present invention physical and/or psychological dependency on alcohol, caffeine, or nicotine by the regular consumption of alcoholic or caffeine-containing drinks and tobacco products.
- dependencies for the purposes of the present invention are also meant general, non-substance-related dependencies, such as may be observed, for example, in bulimia or addiction to exercise, etc.
- Preferred dopamine agonists which may be used within the scope of the present invention are selected from among pramipexole, talipexole, ropinirole, apomorphine, lisuride, terguride, pergolide, cabergoline, bromocriptine, ( ⁇ )-quinpirol, and (+)-7-OH-DPAT, optionally in the form of their enantiomers, optionally in the form of the pharmacologically acceptable acid addition salts thereof, and optionally in the form of the hydrates and solvates thereof.
- Particularly preferred dopamine agonists within the scope of their use according to the invention are selected from among pramipexole, talipexole, and ropinirole, optionally in the form of their enantiomers, optionally in the form of the pharmacologically acceptable acid addition salts thereof, and optionally in the form of the hydrates and solvates thereof.
- dopamine agonists selected from pramipexole and talipexole, optionally in the form of their enantiomers, optionally in the form of the pharmacologically acceptable acid addition salts thereof, and optionally in the form of the hydrates and solvates thereof.
- any reference to one of the abovementioned dopamine agonists includes a reference to any enantiomers of the compound in question which may exist.
- a reference to pramipexole also includes a reference to the (+)-enantiomer as well as the ( ⁇ )-enantiomer.
- the ( ⁇ )-enantiomer is of particular importance.
- the dopamine agonists which may be used according to the invention may optionally be used in the form of the pharmaceutically acceptable acid addition salts thereof as well as optionally in the form of its hydrates and/or solvates.
- pharmaceutically acceptable acid addition salts of the dopamine agonists are meant according to the invention the salts selected from the salts of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, methanesulfonic acid, acetic acid, fumaric acid, succinic acid, lactic acid, citric acid, tartaric acid, and maleic acid, of which the salts of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, and acetic acid are particularly preferred.
- the salts of hydrochloric acid are particularly important.
- the hydrochlorides are preferably used, pramipexole dihydrochloride being of particular significance.
- pramipexole dihydrochloride monohydrate is particularly preferred.
- the dopamine agonists which may be used according to the invention may optionally be used in combination with other active substances.
- Preferred partners in the combination are compounds selected from the categories of the antidepressants, tranquilizers and sedatives. Synergistic effects in the intended activity mean that when combinations containing one of the additional active substances mentioned above as well as the dopamine agonists are used the dosage of the individual components is reduced.
- the dosage of the dopamine agonists naturally depends to a great extent on the severity of the symptoms to be treated, on the one hand, and on the choice of active substance, on the other.
- some possible doses will now be given, particularly for the compound pramipexole which is particularly preferred according to the invention.
- This compound may be used in doses of about 0.05 mg to 3 mg, preferably 0.1 mg to 1.5 mg per day. These doses are based on pramipexole in the form of its free base.
- the doses mentioned above correspond to about 0.07 mg to 4.26 mg, preferably 0.14 mg to 2.13 mg of pramipexole dihydrochloride monohydrate per day.
- the dopamine agonists may be administered orally, transdermally, intrathecally, by inhalation, or parenterally.
- Suitable preparations include, for example, tablets, capsules, suppositories, solutions, syrups, emulsions, dispersible powders, or patches.
- transdermal preparation which may be used according to the invention, we now refer to the embodiments described by way of example in U.S. Pat. No. 5,112,842, which is hereby incorporated by reference in its entirety.
- Suitable tablets may be produced, for example, by mixing the active substance or substances with known excipients, for example, inert diluents, such as calcium carbonate, calcium phosphate or lactose, disintegrants such as corn starch or alginic acid, binders such as starch or gelatine, lubricants such as magnesium stearate or talc, and/or agents for achieving delayed release such as carboxymethylcellulose, cellulose acetate phthalate, or polyvinyl acetate.
- excipients for example, inert diluents, such as calcium carbonate, calcium phosphate or lactose, disintegrants such as corn starch or alginic acid, binders such as starch or gelatine, lubricants such as magnesium stearate or talc, and/or agents for achieving delayed release such as carboxymethylcellulose, cellulose acetate phthalate, or polyvinyl acetate.
- excipients for example, inert
- Tablet 1 Ingredient Amount (mg) pramipexole dihydrochloride monohydrate 1.00 mannitol 121.50 maize starch 79.85 highly dispersed silicon dioxide, anhydrous 2.30 Polyvidone K25 2.35 magnesium stearate 3.00 Total 210.00
- Tablet 2 Ingredient Amount (mg) pramipexole 0.5 mannitol 122.0 maize starch, dried 61.8 maize starch 18.0 highly dispersed silicon dioxide, anhydrous 2.4 Polyvidone K25 2.3 magnesium stearate 3.0 Total 210.0
- Tablet 3 Ingredient Amount (mg) pramipexole 0.25 mannitol 61.00 maize starch 39.90 highly dispersed silicon dioxide, anhydrous 1.20 Polyvidone K25 1.15 magnesium stearate 1.5 Total 105.00
- Tablet 4 Ingredient Amount (mg) pramipexole 0.125 mannitol 49.455 maize starch dried 25.010 maize starch 7.300 highly dispersed silicon dioxide, anhydrous 0.940 Polyvidone K25 0.940 magnesium stearate 1.230 Total 85.000 Solution for injection pramipexole dihydrochloride monohydrate 0.3 mg sodium chloride 0.8 mg benzalkonium chloride 0.01 mg water for injection ad 100 ml
Abstract
A method of treating anhedonia in a patient in need thereof, comprising administering to the patient an effective amount of a dopamine agonist
Description
- This is a Continuation of U.S. Ser. No. 10/213,296 filed Aug. 6, 2002 and benefit under 35 U.S.C. § 119(e) of prior provisional application Ser. No. 60/312,332, filed Aug. 14, 2001, is hereby claimed.
- The invention relates to the use of dopamine agonists for preparing a pharmaceutical composition for overcoming and/or alleviating anhedonia.
- The term anhedonia is used in the prior art to denote a series of symptomatic conditions. Thus, the word anhedonia is used, for example, to denote loss of pleasure in life as well as an inability to derive any enjoyment from experiences or stimulations which normally give pleasure. Occasionally, anhedonia is divided into social anhedonia (for example, the loss of pleasure in being with friends) and psychic anhedonia (for example, the loss of pleasure in observing the beauty of nature). As a symptom anhedonia is found in psychiatric clinical pictures such as severe depression, schizophrenia, and dependency diseases. It may possibly also occur as a result of serious stress and extreme situations.
- It has now been found that, surprisingly, dopamine agonists may usefully be used in therapeutically effective doses to overcome and/or alleviate anhedonia.
- Accordingly, the present invention relates to the use of dopamine agonists for preparing a pharmaceutical composition for overcoming and/or alleviating anhedonia.
- Preferably, the present invention relates to the use of dopamine agonists for preparing a pharmaceutical composition for overcoming and/or alleviating anhedonia in diseases of dependency.
- By dependency diseases are meant within the scope of the present invention diseases or disorders of the state of health, which result from the physical and/or psychological dependency of an individual on drugs and/or medication, for example. Dependency on medication may arise, for example, as a result of regularly taking active substances, such as opiates, for example. Drug dependency may arise, for example, as a result of regularly taking heroin, cocaine, marijuana, and the like. By drug dependency is also meant within the scope of the present invention physical and/or psychological dependency on alcohol, caffeine, or nicotine by the regular consumption of alcoholic or caffeine-containing drinks and tobacco products.
- By dependencies for the purposes of the present invention are also meant general, non-substance-related dependencies, such as may be observed, for example, in bulimia or addiction to exercise, etc.
- The withdrawal of accustomed, rewarding triggers generally leads to a number of pathological psychophysiological reactions. Therapeutic approaches are known in the prior art in which attempts are made to substitute the original addiction triggers with other, less harmful substances. These are intended to alleviate the withdrawal without themselves leading to dependency. A more targeted approach is to analyze the symptoms of the dependency more precisely and then specifically to eliminate these. Admittedly, this is only treating the symptoms to begin with, but as a result of being freed from the craving for more addiction-producing agents over and over again, the body is given the time it needs to recover in the longer term.
- During withdrawal, states of excitement and restlessness as well as marked anhedonia occur in particular. Whereas attempts have already been made to treat the former with corresponding preclinical approaches, until now there have been no suitable preclinical models for specifically treating anhedonia. This is where the present invention comes in. In a newly developed experiment it has been possible preclinically for the first time to make anhedonia probable in animals, and surprisingly the substances claimed have worked convincingly in this very model. They relieve the symptoms of anhedonia with a convincing degree of reproducibility at unusually low doses. Until now, such a convincing activity has not been detected with any other substance.
- Preferred dopamine agonists which may be used within the scope of the present invention are selected from among pramipexole, talipexole, ropinirole, apomorphine, lisuride, terguride, pergolide, cabergoline, bromocriptine, (−)-quinpirol, and (+)-7-OH-DPAT, optionally in the form of their enantiomers, optionally in the form of the pharmacologically acceptable acid addition salts thereof, and optionally in the form of the hydrates and solvates thereof.
- Particularly preferred dopamine agonists within the scope of their use according to the invention are selected from among pramipexole, talipexole, and ropinirole, optionally in the form of their enantiomers, optionally in the form of the pharmacologically acceptable acid addition salts thereof, and optionally in the form of the hydrates and solvates thereof.
- Of exceptional importance within the scope of their use according to the invention are the dopamine agonists selected from pramipexole and talipexole, optionally in the form of their enantiomers, optionally in the form of the pharmacologically acceptable acid addition salts thereof, and optionally in the form of the hydrates and solvates thereof.
- Any reference to one of the abovementioned dopamine agonists includes a reference to any enantiomers of the compound in question which may exist. For example, a reference to pramipexole also includes a reference to the (+)-enantiomer as well as the (−)-enantiomer. Within the scope of the present invention, however, the (−)-enantiomer is of particular importance.
- The dopamine agonists which may be used according to the invention may optionally be used in the form of the pharmaceutically acceptable acid addition salts thereof as well as optionally in the form of its hydrates and/or solvates. By pharmaceutically acceptable acid addition salts of the dopamine agonists are meant according to the invention the salts selected from the salts of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, methanesulfonic acid, acetic acid, fumaric acid, succinic acid, lactic acid, citric acid, tartaric acid, and maleic acid, of which the salts of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, and acetic acid are particularly preferred. The salts of hydrochloric acid are particularly important.
- In the case of pramipexole which is particularly preferably used according to the invention, the hydrochlorides are preferably used, pramipexole dihydrochloride being of particular significance. Of the hydrates of pramipexole, pramipexole dihydrochloride monohydrate is particularly preferred.
- The dopamine agonists which may be used according to the invention may optionally be used in combination with other active substances. Preferred partners in the combination are compounds selected from the categories of the antidepressants, tranquilizers and sedatives. Synergistic effects in the intended activity mean that when combinations containing one of the additional active substances mentioned above as well as the dopamine agonists are used the dosage of the individual components is reduced.
- The dosage of the dopamine agonists naturally depends to a great extent on the severity of the symptoms to be treated, on the one hand, and on the choice of active substance, on the other. For example, without restricting the present invention thereto, some possible doses will now be given, particularly for the compound pramipexole which is particularly preferred according to the invention. This compound may be used in doses of about 0.05 mg to 3 mg, preferably 0.1 mg to 1.5 mg per day. These doses are based on pramipexole in the form of its free base. Based on the salt form pramipexole dihydrochloride monohydrate which is preferably used, the doses mentioned above correspond to about 0.07 mg to 4.26 mg, preferably 0.14 mg to 2.13 mg of pramipexole dihydrochloride monohydrate per day.
- One possible dosing method, which is to be understood as being merely an illustrative example, is described below, based on pramipexole in the form of its free base: individual dosage titration at weekly intervals depending on activity and acceptability.
-
- 1st week: 1 tablet containing 0.088 mg of pramipexole 3 times a day;
- 2nd week: 1 tablet containing 0.18 mg of pramipexole 3 times a day; and
- 3rd week and thereafter: ½ tablet containing 0.7 mg of pramipexole 3 times a day.
- Within the scope of the use according to the invention, the dopamine agonists may be administered orally, transdermally, intrathecally, by inhalation, or parenterally. Suitable preparations include, for example, tablets, capsules, suppositories, solutions, syrups, emulsions, dispersible powders, or patches. Regarding possible embodiments of a transdermal preparation which may be used according to the invention, we now refer to the embodiments described by way of example in U.S. Pat. No. 5,112,842, which is hereby incorporated by reference in its entirety. Suitable tablets may be produced, for example, by mixing the active substance or substances with known excipients, for example, inert diluents, such as calcium carbonate, calcium phosphate or lactose, disintegrants such as corn starch or alginic acid, binders such as starch or gelatine, lubricants such as magnesium stearate or talc, and/or agents for achieving delayed release such as carboxymethylcellulose, cellulose acetate phthalate, or polyvinyl acetate. The tablets may also consist of several layers.
- The following are some examples of pharmaceutical preparations which may be used according to the invention. These are intended solely as an illustration without restricting the subject matter of the invention thereto.
Tablet 1 Ingredient Amount (mg) pramipexole dihydrochloride monohydrate 1.00 mannitol 121.50 maize starch 79.85 highly dispersed silicon dioxide, anhydrous 2.30 Polyvidone K25 2.35 magnesium stearate 3.00 Total 210.00 -
Tablet 2 Ingredient Amount (mg) pramipexole 0.5 mannitol 122.0 maize starch, dried 61.8 maize starch 18.0 highly dispersed silicon dioxide, anhydrous 2.4 Polyvidone K25 2.3 magnesium stearate 3.0 Total 210.0 -
Tablet 3 Ingredient Amount (mg) pramipexole 0.25 mannitol 61.00 maize starch 39.90 highly dispersed silicon dioxide, anhydrous 1.20 Polyvidone K25 1.15 magnesium stearate 1.5 Total 105.00 -
Tablet 4 Ingredient Amount (mg) pramipexole 0.125 mannitol 49.455 maize starch dried 25.010 maize starch 7.300 highly dispersed silicon dioxide, anhydrous 0.940 Polyvidone K25 0.940 magnesium stearate 1.230 Total 85.000 Solution for injection pramipexole dihydrochloride monohydrate 0.3 mg sodium chloride 0.8 mg benzalkonium chloride 0.01 mg water for injection ad 100 ml
Claims (12)
1. A method of treating anhedonia in a patient in need thereof, comprising administering to the patient an effective amount of a dopamine agonist.
2. The method of claim 1 , wherein the anhedonia is associated with a dependency disease.
3. The method of claim 1 , wherein the dopamine agonist is selected from pramipexole, talipexole, ropinirole, apomorphine, lisuride, terguride, pergolide, cabergoline, bromocriptine, (−)-quinpirol, and (+)-7-OH-DPAT, or an enantiomer, pharmacologically acceptable acid addition salt, hydrate, or solvate thereof.
4. The method of claim 2 , wherein the dopamine agonist is selected from pramipexole, talipexole, ropinirole, apomorphine, lisuride, terguride, pergolide, cabergoline, bromocriptine, (−)-quinpirol, and (+)-7-OH-DPAT, or an enantiomer, pharmacologically acceptable acid addition salt, hydrate, or solvate thereof.
5. The method of claim 1 , wherein the dopamine agonist is selected from pramipexole, talipexole, and ropinirole, or an enantiomer, pharmacologically acceptable acid addition salt, hydrate, or solvate thereof.
6. The method of claim 2 , wherein the dopamine agonist is selected from pramipexole, talipexole, and ropinirole, or an enantiomer, pharmacologically acceptable acid addition salt, hydrate, or solvate thereof.
7. The method of claim 1 , wherein the dopamine agonist is pramipexole, or an enantiomer, pharmacologically acceptable acid addition salt, hydrate, or solvate thereof.
8. The method of claim 2 , wherein the dopamine agonist is pramipexole, or an enantiomer, pharmacologically acceptable acid addition salt, hydrate, or solvate thereof.
9. The method of claim 1 , wherein the dopamine agonist is pramipexole dihydrochloride.
10. The method of claim 2 , wherein the dopamine agonist is pramipexole dihydrochloride.
11. The method of claim 1 , wherein the dopamine agonist is pramipexole dihydrochloride monohydrate.
12. The method of claim 2 , wherein the dopamine agonist is pramipexole dihydrochloride monohydrate.
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US10/941,524 US20050032806A1 (en) | 2001-08-10 | 2004-09-15 | Method for treating anhedonia using dopamine agonists |
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DE10138275A DE10138275A1 (en) | 2001-08-10 | 2001-08-10 | Connections to eliminate anhedonia |
DE10138275.8 | 2001-08-10 | ||
US31233201P | 2001-08-14 | 2001-08-14 | |
US10/213,296 US20030036548A1 (en) | 2001-08-10 | 2002-08-06 | Method for treating anhedonia using dopamine agonists |
US10/941,524 US20050032806A1 (en) | 2001-08-10 | 2004-09-15 | Method for treating anhedonia using dopamine agonists |
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US10/213,296 Continuation US20030036548A1 (en) | 2001-08-10 | 2002-08-06 | Method for treating anhedonia using dopamine agonists |
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US10/941,524 Abandoned US20050032806A1 (en) | 2001-08-10 | 2004-09-15 | Method for treating anhedonia using dopamine agonists |
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EP (1) | EP1418908B1 (en) |
JP (1) | JP2005525994A (en) |
AT (1) | ATE374025T1 (en) |
CA (1) | CA2455585A1 (en) |
DE (2) | DE10138275A1 (en) |
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EP2431026A1 (en) | 2004-08-13 | 2012-03-21 | Boehringer Ingelheim International GmbH | Extended release pellet formulation containing Pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof |
ES2355735T5 (en) | 2004-08-13 | 2014-06-27 | Boehringer Ingelheim International Gmbh | Formulation in extended-release tablets containing pramipexole or a pharmaceutically acceptable salt thereof, method of manufacture and use |
JPWO2007049626A1 (en) * | 2005-10-27 | 2009-04-30 | キッセイ薬品工業株式会社 | Cabergoline-containing oral solid preparation |
US20090098202A1 (en) * | 2006-02-10 | 2009-04-16 | Boehringer Ingelheim International Gmbh | Extended Release Formulation |
CN102836155A (en) * | 2012-08-30 | 2012-12-26 | 天津红日药业股份有限公司 | Medicinal composition containing pramipexole |
CN103961325B (en) * | 2013-02-03 | 2018-08-21 | 南京圣和药业股份有限公司 | The preparation method of Pramipexole tablet and thus obtained tablet and its application |
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-
2001
- 2001-08-10 DE DE10138275A patent/DE10138275A1/en not_active Withdrawn
-
2002
- 2002-08-03 EP EP02758431A patent/EP1418908B1/en not_active Expired - Lifetime
- 2002-08-03 ES ES02758431T patent/ES2292794T3/en not_active Expired - Lifetime
- 2002-08-03 WO PCT/EP2002/008691 patent/WO2003013521A1/en active IP Right Grant
- 2002-08-03 MX MXPA04001205A patent/MXPA04001205A/en not_active Application Discontinuation
- 2002-08-03 JP JP2003518530A patent/JP2005525994A/en active Pending
- 2002-08-03 AT AT02758431T patent/ATE374025T1/en active
- 2002-08-03 CA CA002455585A patent/CA2455585A1/en not_active Abandoned
- 2002-08-03 DE DE50210987T patent/DE50210987D1/en not_active Expired - Lifetime
- 2002-08-06 US US10/213,296 patent/US20030036548A1/en not_active Abandoned
-
2004
- 2004-09-15 US US10/941,524 patent/US20050032806A1/en not_active Abandoned
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US6410527B1 (en) * | 1998-03-02 | 2002-06-25 | Schering Corporation | Method of treating obsessive compulsive disorders, somatoform disorders, dissociative disorders, eating disorders, impulse control disorders, and autism |
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Also Published As
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WO2003013521A1 (en) | 2003-02-20 |
US20030036548A1 (en) | 2003-02-20 |
EP1418908A1 (en) | 2004-05-19 |
EP1418908B1 (en) | 2007-09-26 |
MXPA04001205A (en) | 2004-05-20 |
ATE374025T1 (en) | 2007-10-15 |
DE10138275A1 (en) | 2003-02-27 |
ES2292794T3 (en) | 2008-03-16 |
CA2455585A1 (en) | 2003-02-20 |
DE50210987D1 (en) | 2007-11-08 |
JP2005525994A (en) | 2005-09-02 |
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