US20040050074A1 - Apparatus for controlling a microtome and a cooling chamber provided therefor - Google Patents
Apparatus for controlling a microtome and a cooling chamber provided therefor Download PDFInfo
- Publication number
- US20040050074A1 US20040050074A1 US10/660,142 US66014203A US2004050074A1 US 20040050074 A1 US20040050074 A1 US 20040050074A1 US 66014203 A US66014203 A US 66014203A US 2004050074 A1 US2004050074 A1 US 2004050074A1
- Authority
- US
- United States
- Prior art keywords
- cooling chamber
- microtome
- control unit
- operating elements
- display
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L1/00—Enclosures; Chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2400/00—General features of, or devices for refrigerators, cold rooms, ice-boxes, or for cooling or freezing apparatus not covered by any other subclass
- F25D2400/36—Visual displays
- F25D2400/361—Interactive visual displays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/42—Low-temperature sample treatment, e.g. cryofixation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
- G01N2001/065—Drive details
- G01N2001/066—Drive details electric
Definitions
- the present invention concerns an apparatus for controlling a microtome and a cooling chamber provided therefor.
- U.S. Pat. No. 6,178,757 describes a control apparatus for a cooling chamber into which a microtome or ultramicrotome is placed.
- the control apparatus encompasses a microcontroller to which a first and a second control circuit for the sample and the knife are connected.
- An adjusting element is provided for adjusting and also correspondingly monitoring the desired temperature for the knife and sample.
- Control of a system that comprises a microtome and a cooling chamber is described in the brochure for the Leica Ultracut S/FCS.
- a first control unit is used for control purposes and for the input of cutting parameters for the microtome.
- the second control device serves exclusively for adjustment and temperature regulation of the cooling chamber around the region of the knife and the sample holder. Since the space available on laboratory benches is usually limited, a plurality of control units is not necessarily especially suitable.
- the RCM company proposes, in its company brochure, the variant of a small cooling chamber control unit.
- This control unit can be placed on the ultramicrotome control unit. Nevertheless, two separate control units are still provided, and the power supply and power electronics for the cooling chamber control unit are additionally housed in a “black box.” This additional black box need not be placed on the laboratory bench, since it contains no operating elements. An additional part of a system is created, however, which is not conducive to user-friendliness.
- the Leica CM 3600 discloses a sectioning device for large biological tissues. There is a programmable logic unit controller provided which allows input of study related data. The Leica CM 3600 does not disclose two separate units which are controlled by one control device.
- the Leica CM 3050 S shows a cryostat system which can produce slices at low temperatures.
- the difference to the present invention is that the whole system is covered with a temperature shielding housing and the housing itself includes control buttons.
- an apparatus for controlling a microtome and a cooling chamber, which is positioned on the microtome comprising:
- a single display is associated with the control unit, wherein the single display is, dependent from the specific configuration of microtome and cooling chamber, a user interface for the microtome and/or the cooling chamber.
- the apparatus for controlling a microtome and a cooling chamber provided therefor has the critical advantage that a single control unit is provided that integrates both operating elements for the microtome and operating elements for the cooling chamber.
- a user interface that is embodied in the form of a display or screen.
- the operating elements can be presented to a user on the display.
- the control unit is configured in such a way that a cooling chamber connected to the microtome can be detected.
- the control unit modifies or adds to the operating elements presented on the display in accordance with the operating elements for the cooling chamber.
- control unit is arranged and/or organized better.
- the power electronics and/or power supplies which are not housed in this control unit, can be assigned to the devices (microtome or cooling chamber).
- a black box or an external power supply is also conceivable. It is furthermore advantageous that the invention not only achieves the space reduction, but also makes possible a cost reduction. This is important principally for customers who do not originally possess a cooling chamber, since the control unit has cooling-chamber costs associated with it.
- FIG. 1 is a schematic side view of the microtome with a cooling chamber and control unit
- FIG. 2 is a schematic side view of another embodiment of the microtome with cooling chamber and control unit.
- FIG. 3 schematically depicts a user interface for the shared control unit.
- FIG. 1 is the a schematic side view of a microtome 2 that is equipped with a cooling chamber 4 .
- microtome is used in the foregoing description and in the description to follow, this term is also, of course, understood to mean an ultramicrotome.
- cooling chamber 4 is marked with dashed lines.
- Microtome 2 possesses a sample holder 6 that is movable up and down. Also provided on the microtome is a knife holder 8 which is arranged in such a way that it is located opposite a sample 10 mounted on sample holder 6 .
- a shared control unit 12 is provided.
- Control unit 12 , microtome 2 , and cooling chamber 4 are each connected using an electrical conductor 14 .
- a display 16 on which a user interface, for adjusting microtome 2 and cooling chamber 4 , is displayed.
- the user interface makes adjustment icons or buttons for microtome 2 and cooling chamber 4 available to the user. Since it often happens that customers first purchase microtome 2 and later opt for a cooling chamber 4 , control unit 12 is designed so that it detects, for example, a cooling chamber that has just been connected, and rearranges or adapts the user interface in accordance with the new configuration of the system. Operating elements that are connected to control unit 12 can assume various configurations.
- buttons can be embodied as buttons, rotary encoders, or joysticks, and can have various functions.
- display 16 is a touch screen on which, alongside the operating elements for microtome 2 , additional or different operating elements for cooling chamber 4 can be displayed. Actuation of the operating elements using external input devices such as a mouse, trackball, etc. is also possible.
- FIG. 2 depicts a different exemplary embodiment of the invention. Identical reference characters are used for identical elements.
- control unit 12 is provided in microtome 2 , and is hereinafter labeled with the reference character 18 .
- a detection device 20 which is connected to a control unit 18 via a conductor 22 , is provided between microtome 2 and cooling chamber 4 .
- Detection device 20 can be embodied as a plug connector, a transponder, a scanner, a barcode reader, etc. In the case of a scanner or barcode reader, a label or a barcode (not depicted) is advantageously provided on cooling chamber 4 .
- the label or barcode are applied on cooling chamber 4 in such a way that when a cooling chamber 4 is placed on a microtome 2 , it is located opposite detection device 20 .
- a trackball 24 for example, with which multiple actuation elements for microtome 2 and/or for cooling chamber 4 can be operated on display 16 by the user, is connected to control unit 18 .
- Display 16 itself is connected via a conductor 24 to control unit 18 .
- a wireless connection between display 16 and control unit 18 is also conceivable.
- FIG. 3 is a schematic depiction of a user interface for the shared control unit 12 or 18 .
- the description below refers to the embodiment depicted in FIG. 3, but it is self-evident that this is not to be construed as a limitation.
- Multiple operating elements 30 for microtome 2 , and multiple operating elements 32 for cooling chamber 4 if applicable, are displayed on display 16 .
- FIG. 3 depicts the situation in which a cooling chamber 4 is connected to microtome 2 .
- Control unit 12 or 18 detects the cooling chamber, so that display 16 is divided by means of a software program into a first part 16 a and a second part 16 b .
- Operating elements 32 for cooling chamber 4 are displayed in first part 16 a , and operating elements 30 for microtome 2 in second part 16 b .
- Operating elements 32 for cooling chamber 4 can encompass, for example, setpoint temperature, actual temperature, cooling rate, etc.
- Operating elements 30 for microtome 2 can encompass, for example, cutting speed, sample feed, etc.
- Operating elements 30 and 32 can be equipped with a pull-down menu 34 with which the user can select defined parameter increments or also make user-defined inputs.
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Description
- This application claims priority of the
German patent application 102 42 712.7 which is incorporated by reference herein. - The present invention concerns an apparatus for controlling a microtome and a cooling chamber provided therefor.
- U.S. Pat. No. 6,178,757 describes a control apparatus for a cooling chamber into which a microtome or ultramicrotome is placed. The control apparatus encompasses a microcontroller to which a first and a second control circuit for the sample and the knife are connected. An adjusting element is provided for adjusting and also correspondingly monitoring the desired temperature for the knife and sample.
- Control of a system that comprises a microtome and a cooling chamber is described in the brochure for the Leica Ultracut S/FCS. There are two separate control units for the overall system. A first control unit is used for control purposes and for the input of cutting parameters for the microtome. The second control device serves exclusively for adjustment and temperature regulation of the cooling chamber around the region of the knife and the sample holder. Since the space available on laboratory benches is usually limited, a plurality of control units is not necessarily especially suitable.
- In order to solve the problem of insufficient space, the RCM company proposes, in its company brochure, the variant of a small cooling chamber control unit. This control unit can be placed on the ultramicrotome control unit. Nevertheless, two separate control units are still provided, and the power supply and power electronics for the cooling chamber control unit are additionally housed in a “black box.” This additional black box need not be placed on the laboratory bench, since it contains no operating elements. An additional part of a system is created, however, which is not conducive to user-friendliness.
- The Leica CM 3600 discloses a sectioning device for large biological tissues. There is a programmable logic unit controller provided which allows input of study related data. The Leica CM 3600 does not disclose two separate units which are controlled by one control device.
- The Leica CM 3050 S shows a cryostat system which can produce slices at low temperatures. The difference to the present invention is that the whole system is covered with a temperature shielding housing and the housing itself includes control buttons.
- It is therefore the object of the invention to create a unified, space-saving, and user-friendly control system for a system made up of a microtome and a separate cooling chamber.
- The object is achieved, according to the present invention, with an apparatus for controlling a microtome and a cooling chamber, which is positioned on the microtome, comprising:
- a single control unit that integrates both operating elements for the microtome and operating elements for the cooling chamber; and
- a single display is associated with the control unit, wherein the single display is, dependent from the specific configuration of microtome and cooling chamber, a user interface for the microtome and/or the cooling chamber.
- The apparatus for controlling a microtome and a cooling chamber provided therefor has the critical advantage that a single control unit is provided that integrates both operating elements for the microtome and operating elements for the cooling chamber. Associated with the control unit is a user interface that is embodied in the form of a display or screen. The operating elements can be presented to a user on the display. The control unit is configured in such a way that a cooling chamber connected to the microtome can be detected. The control unit modifies or adds to the operating elements presented on the display in accordance with the operating elements for the cooling chamber.
- It is particularly advantageous that the invention results not only in space reduction on a laboratory bench, but also in simpler handling for the user. It is likewise advantageous and conceivable for functions that are not often used to be presented only in a submenu on the display. The result of this is that the control unit is arranged and/or organized better.
- The power electronics and/or power supplies, which are not housed in this control unit, can be assigned to the devices (microtome or cooling chamber). A black box or an external power supply is also conceivable. It is furthermore advantageous that the invention not only achieves the space reduction, but also makes possible a cost reduction. This is important principally for customers who do not originally possess a cooling chamber, since the control unit has cooling-chamber costs associated with it.
- The invention will be elucidated below with reference to the examples depicted schematically in the Figures, in which:
- FIG. 1 is a schematic side view of the microtome with a cooling chamber and control unit;
- FIG. 2 is a schematic side view of another embodiment of the microtome with cooling chamber and control unit; and
- FIG. 3 schematically depicts a user interface for the shared control unit.
- FIG. 1 is the a schematic side view of a
microtome 2 that is equipped with a cooling chamber 4. Although only the term “microtome” is used in the foregoing description and in the description to follow, this term is also, of course, understood to mean an ultramicrotome. In the depiction of FIGS. 1 and 2, cooling chamber 4 is marked with dashed lines. Microtome 2 possesses a sample holder 6 that is movable up and down. Also provided on the microtome is aknife holder 8 which is arranged in such a way that it is located opposite asample 10 mounted on sample holder 6. In the exemplary embodiment depicted in FIG. 1, a sharedcontrol unit 12 is provided.Control unit 12,microtome 2, and cooling chamber 4 are each connected using anelectrical conductor 14. Associated withcontrol unit 12 is adisplay 16 on which a user interface, for adjustingmicrotome 2 and cooling chamber 4, is displayed. The user interface makes adjustment icons or buttons formicrotome 2 and cooling chamber 4 available to the user. Since it often happens that customers first purchasemicrotome 2 and later opt for a cooling chamber 4,control unit 12 is designed so that it detects, for example, a cooling chamber that has just been connected, and rearranges or adapts the user interface in accordance with the new configuration of the system. Operating elements that are connected tocontrol unit 12 can assume various configurations. For example, they can be embodied as buttons, rotary encoders, or joysticks, and can have various functions. Also conceivable fordisplay 16 is a touch screen on which, alongside the operating elements formicrotome 2, additional or different operating elements for cooling chamber 4 can be displayed. Actuation of the operating elements using external input devices such as a mouse, trackball, etc. is also possible. - FIG. 2 depicts a different exemplary embodiment of the invention. Identical reference characters are used for identical elements. Here
control unit 12 is provided inmicrotome 2, and is hereinafter labeled with thereference character 18. Adetection device 20, which is connected to acontrol unit 18 via aconductor 22, is provided betweenmicrotome 2 and cooling chamber 4.Detection device 20 can be embodied as a plug connector, a transponder, a scanner, a barcode reader, etc. In the case of a scanner or barcode reader, a label or a barcode (not depicted) is advantageously provided on cooling chamber 4. The label or barcode are applied on cooling chamber 4 in such a way that when a cooling chamber 4 is placed on amicrotome 2, it is locatedopposite detection device 20. A trackball 24, for example, with which multiple actuation elements formicrotome 2 and/or for cooling chamber 4 can be operated ondisplay 16 by the user, is connected to controlunit 18.Display 16 itself is connected via a conductor 24 to controlunit 18. A wireless connection betweendisplay 16 andcontrol unit 18 is also conceivable. - FIG. 3 is a schematic depiction of a user interface for the shared
control unit Multiple operating elements 30 formicrotome 2, andmultiple operating elements 32 for cooling chamber 4 if applicable, are displayed ondisplay 16. FIG. 3 depicts the situation in which a cooling chamber 4 is connected tomicrotome 2.Control unit display 16 is divided by means of a software program into afirst part 16 a and asecond part 16 b.Operating elements 32 for cooling chamber 4 are displayed infirst part 16 a, and operatingelements 30 formicrotome 2 insecond part 16 b.Operating elements 32 for cooling chamber 4 can encompass, for example, setpoint temperature, actual temperature, cooling rate, etc.Operating elements 30 formicrotome 2 can encompass, for example, cutting speed, sample feed, etc.Operating elements down menu 34 with which the user can select defined parameter increments or also make user-defined inputs.
Claims (7)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEDE10242712.7-52 | 2002-09-13 | ||
DE10242712A DE10242712B4 (en) | 2002-09-13 | 2002-09-13 | Microtome with a control device |
Publications (2)
Publication Number | Publication Date |
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US20040050074A1 true US20040050074A1 (en) | 2004-03-18 |
US6860113B2 US6860113B2 (en) | 2005-03-01 |
Family
ID=31969128
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/660,142 Expired - Lifetime US6860113B2 (en) | 2002-09-13 | 2003-09-11 | Apparatus for controlling a microtome and a cooling chamber provided therefor |
Country Status (2)
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US (1) | US6860113B2 (en) |
DE (1) | DE10242712B4 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2419660A (en) * | 2004-09-16 | 2006-05-03 | Thermo Shandon Ltd | Cryostat and microtome |
WO2010081497A1 (en) * | 2009-01-16 | 2010-07-22 | Htl Handel, Logistik Und Technologie Gmbh | Microtome |
US20140090531A1 (en) * | 2008-09-16 | 2014-04-03 | Leica Biosystems Nussloch Gmbh | Microtome for producing sections of specimens |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004053073B3 (en) * | 2004-11-03 | 2006-05-04 | Leica Mikrosysteme Gmbh | High pressure freezing device, automatic loading device for preparations in a high pressure freezing device and method for feeding a high pressure freezing device |
US8869666B2 (en) | 2011-03-24 | 2014-10-28 | Sakura Finetek U.S.A., Inc. | Microtome with surface orientation sensor to sense orientation of surface of sample |
US9032854B2 (en) | 2011-12-21 | 2015-05-19 | Sakura Finetek U.S.A., Inc. | Reciprocating microtome drive system |
AT518720A1 (en) * | 2016-05-19 | 2017-12-15 | Luttenberger Herbert | microtome |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3204424A (en) * | 1962-10-23 | 1965-09-07 | Ames Atomium Inc | Microtome specimen-freezing apparatus |
US4979376A (en) * | 1988-10-10 | 1990-12-25 | Manfred Biehl | Microtomy device |
US5048300A (en) * | 1989-05-26 | 1991-09-17 | Reichert-Jung Optische Werke A.G. | Microtome cooling chamber and method of adjusting the cooling chamber temperature |
US5533342A (en) * | 1995-02-08 | 1996-07-09 | Gordon; Abe | Semi-automated cryostat |
US6178757B1 (en) * | 1998-09-01 | 2001-01-30 | Leica Microsysteme Ag | Cooling chamber temperature control device |
-
2002
- 2002-09-13 DE DE10242712A patent/DE10242712B4/en not_active Expired - Lifetime
-
2003
- 2003-09-11 US US10/660,142 patent/US6860113B2/en not_active Expired - Lifetime
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3204424A (en) * | 1962-10-23 | 1965-09-07 | Ames Atomium Inc | Microtome specimen-freezing apparatus |
US4979376A (en) * | 1988-10-10 | 1990-12-25 | Manfred Biehl | Microtomy device |
US5048300A (en) * | 1989-05-26 | 1991-09-17 | Reichert-Jung Optische Werke A.G. | Microtome cooling chamber and method of adjusting the cooling chamber temperature |
US5533342A (en) * | 1995-02-08 | 1996-07-09 | Gordon; Abe | Semi-automated cryostat |
US6178757B1 (en) * | 1998-09-01 | 2001-01-30 | Leica Microsysteme Ag | Cooling chamber temperature control device |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2419660A (en) * | 2004-09-16 | 2006-05-03 | Thermo Shandon Ltd | Cryostat and microtome |
US20080041069A1 (en) * | 2004-09-16 | 2008-02-21 | Thermo Shandon Ltd | Cryostat Having Separate Cooling Circuits for Cooling the Chamber and a Sample Holder |
GB2419660B (en) * | 2004-09-16 | 2009-10-28 | Thermo Shandon Ltd | Cryostat and microtome |
US20140090531A1 (en) * | 2008-09-16 | 2014-04-03 | Leica Biosystems Nussloch Gmbh | Microtome for producing sections of specimens |
WO2010081497A1 (en) * | 2009-01-16 | 2010-07-22 | Htl Handel, Logistik Und Technologie Gmbh | Microtome |
EP3848693A1 (en) * | 2009-01-16 | 2021-07-14 | HLT Handel, Logistik und Technologie AG | Microtome |
Also Published As
Publication number | Publication date |
---|---|
DE10242712B4 (en) | 2004-10-21 |
US6860113B2 (en) | 2005-03-01 |
DE10242712A1 (en) | 2004-04-01 |
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