US20030135052A1 - Process for the preparation of tertiary amines from primary amines and nitriles - Google Patents
Process for the preparation of tertiary amines from primary amines and nitriles Download PDFInfo
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- US20030135052A1 US20030135052A1 US10/053,073 US5307301A US2003135052A1 US 20030135052 A1 US20030135052 A1 US 20030135052A1 US 5307301 A US5307301 A US 5307301A US 2003135052 A1 US2003135052 A1 US 2003135052A1
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- 0 **CN(CC)C** Chemical compound **CN(CC)C** 0.000 description 3
- HRDIGEBCGNMFGG-UHFFFAOYSA-N CCCCN(C)CCCO Chemical compound CCCCN(C)CCCO HRDIGEBCGNMFGG-UHFFFAOYSA-N 0.000 description 1
- MALJJOCUWNNURG-UHFFFAOYSA-N CN(CCCO)CCCO.[C-]#[N+]CCCCCN(CCO)CCCCCC#N.[C-]#[N+]CCCCN(C)CCCCCC#N Chemical compound CN(CCCO)CCCO.[C-]#[N+]CCCCCN(CCO)CCCCCC#N.[C-]#[N+]CCCCN(C)CCCCCC#N MALJJOCUWNNURG-UHFFFAOYSA-N 0.000 description 1
- VHGKZEMWTAJZRD-UHFFFAOYSA-N CN(CCCO)CCCO.[V] Chemical compound CN(CCCO)CCCO.[V] VHGKZEMWTAJZRD-UHFFFAOYSA-N 0.000 description 1
- OLMBVPYKDZSACA-UHFFFAOYSA-L I[V]I.[C-]#[N+]CCCCN(C)CCCCCC#N Chemical compound I[V]I.[C-]#[N+]CCCCN(C)CCCCCC#N OLMBVPYKDZSACA-UHFFFAOYSA-L 0.000 description 1
- VOROTZCOMXRVDP-UHFFFAOYSA-N [C-]#[N+]CCCCCN(C)CCCCCC Chemical compound [C-]#[N+]CCCCCN(C)CCCCCC VOROTZCOMXRVDP-UHFFFAOYSA-N 0.000 description 1
- YCSRFGKAEBBRLC-UHFFFAOYSA-N [C-]#[N+]CCCCCN(C)CCCCCC#N Chemical compound [C-]#[N+]CCCCCN(C)CCCCCC#N YCSRFGKAEBBRLC-UHFFFAOYSA-N 0.000 description 1
- LIULJHJRDVHVDM-UHFFFAOYSA-N [C-]#[N+]CCCCCN(CCO)CCCCCC Chemical compound [C-]#[N+]CCCCCN(CCO)CCCCCC LIULJHJRDVHVDM-UHFFFAOYSA-N 0.000 description 1
- PTRSSFTWKRDNCO-UHFFFAOYSA-M [C-]#[N+]CCCCCN(CCO)CCCCCC#N.[V]I Chemical compound [C-]#[N+]CCCCCN(CCO)CCCCCC#N.[V]I PTRSSFTWKRDNCO-UHFFFAOYSA-M 0.000 description 1
- TXSBKICCWURNCY-UHFFFAOYSA-N [C-]#[N+]CCCCN(C)CCCCCC Chemical compound [C-]#[N+]CCCCN(C)CCCCCC TXSBKICCWURNCY-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
- C07C209/48—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/82—Purification; Separation; Stabilisation; Use of additives
- C07C209/90—Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Definitions
- the present invention relates to a method for the preparation of tertiary amines from primary amines and nitrile moieties under reductive conditions, and products made by such method.
- 3,673,251 discloses the formation of secondary amines by the reaction of primary amines with a nitrile.
- 1,1′-di-(N-methylaminomethyl)biphenyl-3,3′ can be obtained from the reaction of methylamine and 1,1′-dicyanobiphenyl-3,3′.
- R and R′ independently are C1-C12 substituents selected from the group consisting of straight or branched aliphatic, cycloaliphatic, and heterocyclic moieties;
- A is selected from the group consisting of hydrogen, cyano, amide, straight or branched aliphatic, cycloaliphatic, aromatic, heterocyclic, alkoxy, aryloxy, hydroxy, alkylamino, dialkylamino, arylamino, diarylamino, haloaryl, fluorinated alkyl, and silyl moieties;
- A′ is selected from the group consisting of hydrogen, amino, amide, straight or branched aliphatic, cycloaliphatic, aromatic, heterocyclic, alkoxy, aryloxy, hydroxy, alkylamino, dialkylamino, arylamino, diarylamino, haloaryl, fluorinated alkyl, and silyl;
- R′ is a C1-C12 substituent selected from the group consisting of straight or branched aliphatic, cycloaliphatic, and heterocyclic moieties;
- A′ is selected from the group consisting of hydrogen, amino, amide, straight or branched aliphatic, cycloaliphatic, aromatic, heterocyclic, alkoxy, aryloxy, hydroxy, alkylamino, dialkylamino, arylamino, diarylamino, haloaryl, fluorinated alkyl, and silyl moieties;
- R is a C1-C12 substituent selected from the group consisting of straight or branched aliphatic, cycloaliphatic, and heterocyclic moieties;
- A is selected from the group consisting of hydrogen, cyano, amide, straight or branched aliphatic, cycloaliphatic, aromatic, heterocyclic, alkoxy, aryloxy, hydroxy, alkylamino, dialkylamino, arylamino, diarylamino, haloaryl, fluorinated alkyl, and silyl moieties;
- tertiary amine compounds prepared by the method described above.
- the present invention discloses a method for preparing tertiary amines from a primary amine and a nitrile moiety under reductive conditions.
- the method is carried out by contacting at least one nitrile compound with at least one primary amine compound. It is preferred that the nitrile is used in molar excess of the primary amine.
- the method can be described generally by equation A.
- R and R′ independently are C1-C12 straight or branched aliphatic, cycloaliphatic, or heterocyclic;
- A is selected from the group consisting of hydrogen, cyano, amide, straight or branched aliphatic, cycloaliphatic, aromatic, heterocyclic, alkoxy, aryloxy, hydroxy, alkylamino, dialkylamino, arylamino, diarylamino, haloaryl, fluorinated alkyl, and silyl;
- A′ is selected from the group consisting of hydrogen, amino, amide, straight or branched aliphatic, cycloaliphatic, aromatic, heterocyclic, alkoxy, aryloxy, hydroxy, alkylamino, dialkylamino, arylamino, diarylamino, haloaryl, fluorinated alkyl, and silyl.
- a few of the many types of compounds that can be prepared by this process include simple trialkyl amines, where one can vary the identity of the alkyl chains around the nitrogen center, making, in the simplest of cases, diethylmethylamine from acetonitrile and methylamine.
- a diamine such as 1,3-diaminopropane, can also be reacted in the same manner with acetronitrile to obtain N,N,N′,N′-tetraethyl-1,3-propanediamine.
- Diols with an internal tertiary amine can be formed by reacting cyano-alkanols with primary amines, under the conditions described herein.
- Another class of compounds afforded efficiently by this invention is bis(cyanoalkyl)aminoalkanes, which are formed by the reaction of dinitriles with primary amines.
- bis(cyanoalkyl)aminoalkanes which are formed by the reaction of dinitriles with primary amines.
- Suitable starting nitriles that can be used in the method of the present invention are depicted in structure (II) below. These compounds can be mono- or bi- or multi-functional. That is, they may contain one or more nitrile groups, and may have one or more other functional groups.
- the R group is a C1 to C12 straight or branched aliphatic, cycloaliphatic, or heterocyclic moiety.
- the A group is hydrogen, cyano, amide, straight or branched aliphatic, cycloaliphatic, aromatic, heterocyclic, alkoxy, aryloxy, hydroxy, alkylamino, dialkylamino, arylamino, diarylamino, haloaryl, fluorinated alkyl, or silyl moiety.
- Suitable starting amines for the present invention can be monoprimary amines or diprimary amines of the structure (III) below, where R′ is a C1-C12 straight or branched aliphatic, cycloaliphatic, or heterocyclic moiety; and where A′ is hydrogen, amino, amide, straight or branched aliphatic, cycloaliphatic, aromatic, heterocyclic, alkoxy, aryloxy, hydroxy, alkylamino, dialkylamino, arylamino, diarylamino, haloaryl, fluorinated alkyl, or a silyl moiety.
- R′ is a C1-C12 straight or branched aliphatic, cycloaliphatic, or heterocyclic moiety
- A′ is hydrogen, amino, amide, straight or branched aliphatic, cycloaliphatic, aromatic, heterocyclic, alkoxy, aryloxy, hydroxy, alkylamino, dialkylamino
- the present invention can be carried out using a 1:1 molar ratio of nitrile to amine. Preferred is an excess of the nitrile to the amine, from about 2:1 to about 5:1. Most preferred is a nitrile to amine ratio of about 2:1 to about 4:1.
- Primary amines that may be used in the present invention can be diamines (having two amine groups, for example, 1,2-diaminocyclohexane).
- the nitrile of the present invention may be a dinitrile (having two nitrile groups, for example, adiponitrile).
- the combinations of starting amines and starting nitrites may be varied.
- either a monoamine or a diamine may be used in the method of the present invention with either a mononitrile or a dinitrile.
- one or more primary amines may be used with a combination of nitrites; or one or more nitrites with a combination of amines.
- Table 1 below, but is not intended to limit the scope of the invention described herein.
- Suitable catalysts for the present invention comprise the metal elements selected from the group consisting of palladium, rhodium, platinum, and iridium.
- Preferred catalysts are catalysts comprising palladium.
- Examples of catalysts comprising palladium include, but are not limited to, palladium black or palladium on a support, wherein the palladium content on the support is between about 0.1 and 10 wt. % loading.
- the catalyst also can be comprised of mixed metal compositions.
- the catalyst may comprise palladium with between about 0.1 and 10% of at least one additional metal.
- the preferred elements for the mixed metal compositions to be used with palladium are selected from the group consisting of rhodium, platinum, iridium and ruthenium.
- a support material can be used with the catayst of the present invention.
- Suitable supports include, but are not limited to, activated carbon, silicon carbide and oxidic supports, (for example, alumina, silica, titania, zirconia, magnesia, copper oxide).
- the catalyst can be used in any desired form, including but not limited to extrudate, large granules, pellet, sphere, slurry or dry powder.
- the method of the present invention is carried out under hydrogen pressure of between about 100 and about 1500 psig. Hydrogen pressures between about 500 and 1000 psig are most preferred.
- the temperature should be maintained between about 50° C. and about 200° C., with about 80° C. to about 130° C. being preferred.
- Solvents are not necessary to carry out the method. However solvents such as water, methanol, ethanol, tertiary-butyl ether, tetrahydrofuran, and N-methylpyrrolidinone and other solvents known to dissolve the starting amine and nitrile compounds are suitable. Also, the present invention may be carried out batchwise or in a continuous reactor. The final alkylated amine product can be purified in a conventional manner.
- BCPAM means bis(5-cyanopentyl)aminomethane
- ADN means adiponitrile
- Examples 4-8 in Table 1 demonstrate the disclosed method using different or a combination of nitriles with various amines.
- the examples were carried out in batch mode, using 1 part 5 wt. % Pd/Al 2 O 3 catalyst to 20 parts of starting nitrile; and a hydrogen pressure of 500 psig and a temperature of 100° C. were maintained for 3 hours.
- the unique tertiary amine products of Examples 4, 6 and 8 were analyzed by IR using a Perkin Elmer 1600 Series Fourier Transform Infrared Instrument and a Hewlett Packard 5971 Series Mass Selective Detector in conjunction with a Hewlett Packard 5890 Series Gas Chromatograph.
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Abstract
Description
- The present invention relates to a method for the preparation of tertiary amines from primary amines and nitrile moieties under reductive conditions, and products made by such method.
- New techniques for efficiently preparing common or novel chemicals are continuously sought after by the chemical industry. In particular, any improvements in the synthesis of tertiary amines would be highly valuable, as there are many applications. These applications include use as bioactives, buffers, precursors for surfactants, corrosion inhibitors, and polyurethane catalysts. The ability to incorporate additional functionality, such as nitrites, alcohols, ethers, amides, additional tertiary amine centers, aryl groups, and fluorinated alkyl groups would also be desirable. The additional functionality would allow for the incorporation of a highly functionalized substrate into a polymer backbone, affording the polymer unique properties.
- It is known in the art that under reductive conditions nitrites react with amines to form alkylated amine products. For example, excess dimethylamine, when reacted with adiponitrile under catalytic reductive conditions, undergoes a single reductive amination onto each nitrile to give N,N,N′,N′-tetramethylhexamethylenediamine (U.S. Pat. No. 5,463,130, U.S. Pat. No. 5,557,011 and U.S. Pat. No. 5,894,074). In addition to tertiary amine formation from the reaction of a secondary amine with a nitrile, U.S. Pat. No. 3,673,251 discloses the formation of secondary amines by the reaction of primary amines with a nitrile. For example, 1,1′-di-(N-methylaminomethyl)biphenyl-3,3′ can be obtained from the reaction of methylamine and 1,1′-dicyanobiphenyl-3,3′. However, there has been no disclosure of a method for preparing a tertiary amine directly from a primary amine and a nitrile.
- There is also need for a method that will efficiently provide bis(cyanoalkyl)aminoalkanes, as these compounds are useful precursors for natural products, for substrates that exhibit antitumor activity, and for polymer dye-site additives. To date, these targets have been synthesized by multi-step processes that require the use of an expensive halo-alkylnitrile as an intermediate. For example, Russian researchers (Vasil'eva, E. I.; Freidlina, R. Kh.Izvestiya Akademii Nauk SSR, Seriya Khimicheskaya, No.2, pp. 263-267, February, 1966) disclose the synthesis of bis(5-cyanopentyl)aminomethane, where methylamine reacts with two equivalents of chlorovaleronitrile.
- Since there has been no disclosure of the preparation of tertiary amines directly from primary amines and nitrites, tertiary amines that would be useful in similar applications are unavailable because there are no commercially viable routes to these compounds. A novel route to known tertiary amines and novel tertiary amines prepared from primary amines and nitrites is needed to increase the availability of these types of compounds.
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- wherein R and R′ independently are C1-C12 substituents selected from the group consisting of straight or branched aliphatic, cycloaliphatic, and heterocyclic moieties; and
- wherein A is selected from the group consisting of hydrogen, cyano, amide, straight or branched aliphatic, cycloaliphatic, aromatic, heterocyclic, alkoxy, aryloxy, hydroxy, alkylamino, dialkylamino, arylamino, diarylamino, haloaryl, fluorinated alkyl, and silyl moieties;
- wherein A′ is selected from the group consisting of hydrogen, amino, amide, straight or branched aliphatic, cycloaliphatic, aromatic, heterocyclic, alkoxy, aryloxy, hydroxy, alkylamino, dialkylamino, arylamino, diarylamino, haloaryl, fluorinated alkyl, and silyl;
- said method comprising contacting a primary amine having the general formula
- H2N—R′—A′ (III)
- wherein R′ is a C1-C12 substituent selected from the group consisting of straight or branched aliphatic, cycloaliphatic, and heterocyclic moieties;
- wherein A′ is selected from the group consisting of hydrogen, amino, amide, straight or branched aliphatic, cycloaliphatic, aromatic, heterocyclic, alkoxy, aryloxy, hydroxy, alkylamino, dialkylamino, arylamino, diarylamino, haloaryl, fluorinated alkyl, and silyl moieties;
- with at least one nitrile having the general formula
- A—R—CN (II)
- wherein R is a C1-C12 substituent selected from the group consisting of straight or branched aliphatic, cycloaliphatic, and heterocyclic moieties;
- wherein A is selected from the group consisting of hydrogen, cyano, amide, straight or branched aliphatic, cycloaliphatic, aromatic, heterocyclic, alkoxy, aryloxy, hydroxy, alkylamino, dialkylamino, arylamino, diarylamino, haloaryl, fluorinated alkyl, and silyl moieties;
- in the presence of hydrogen gas and a catalyst at a temperature from about 50° C. to about 200° C. and at a pressure from about 100 psig to 1500 psig.
- Also disclosed are tertiary amine compounds prepared by the method described above.
-
- The present invention discloses a method for preparing tertiary amines from a primary amine and a nitrile moiety under reductive conditions. The method is carried out by contacting at least one nitrile compound with at least one primary amine compound. It is preferred that the nitrile is used in molar excess of the primary amine. The method can be described generally by equation A.
- wherein R and R′ independently are C1-C12 straight or branched aliphatic, cycloaliphatic, or heterocyclic; and
- wherein A is selected from the group consisting of hydrogen, cyano, amide, straight or branched aliphatic, cycloaliphatic, aromatic, heterocyclic, alkoxy, aryloxy, hydroxy, alkylamino, dialkylamino, arylamino, diarylamino, haloaryl, fluorinated alkyl, and silyl;
- wherein A′ is selected from the group consisting of hydrogen, amino, amide, straight or branched aliphatic, cycloaliphatic, aromatic, heterocyclic, alkoxy, aryloxy, hydroxy, alkylamino, dialkylamino, arylamino, diarylamino, haloaryl, fluorinated alkyl, and silyl.
- A few of the many types of compounds that can be prepared by this process include simple trialkyl amines, where one can vary the identity of the alkyl chains around the nitrogen center, making, in the simplest of cases, diethylmethylamine from acetonitrile and methylamine. A diamine, such as 1,3-diaminopropane, can also be reacted in the same manner with acetronitrile to obtain N,N,N′,N′-tetraethyl-1,3-propanediamine. Diols with an internal tertiary amine can be formed by reacting cyano-alkanols with primary amines, under the conditions described herein. Another class of compounds afforded efficiently by this invention is bis(cyanoalkyl)aminoalkanes, which are formed by the reaction of dinitriles with primary amines. By varying the functionality on the primary amine and subsequent hydrogenation of the resulting nitrites, one can produce unique monomers that have a tertiary amine and two primary amines. These unique monomers can then be incorporated into polymers to give the polymers unique physical properties.
- Some of the suitable starting nitriles that can be used in the method of the present invention are depicted in structure (II) below. These compounds can be mono- or bi- or multi-functional. That is, they may contain one or more nitrile groups, and may have one or more other functional groups. The R group is a C1 to C12 straight or branched aliphatic, cycloaliphatic, or heterocyclic moiety. The A group is hydrogen, cyano, amide, straight or branched aliphatic, cycloaliphatic, aromatic, heterocyclic, alkoxy, aryloxy, hydroxy, alkylamino, dialkylamino, arylamino, diarylamino, haloaryl, fluorinated alkyl, or silyl moiety.
- A—R—CN (II)
- Suitable starting amines for the present invention can be monoprimary amines or diprimary amines of the structure (III) below, where R′ is a C1-C12 straight or branched aliphatic, cycloaliphatic, or heterocyclic moiety; and where A′ is hydrogen, amino, amide, straight or branched aliphatic, cycloaliphatic, aromatic, heterocyclic, alkoxy, aryloxy, hydroxy, alkylamino, dialkylamino, arylamino, diarylamino, haloaryl, fluorinated alkyl, or a silyl moiety.
- A′—R′—NH2 (III)
- The present invention can be carried out using a 1:1 molar ratio of nitrile to amine. Preferred is an excess of the nitrile to the amine, from about 2:1 to about 5:1. Most preferred is a nitrile to amine ratio of about 2:1 to about 4:1.
- Primary amines that may be used in the present invention can be diamines (having two amine groups, for example, 1,2-diaminocyclohexane). Similarly, the nitrile of the present invention may be a dinitrile (having two nitrile groups, for example, adiponitrile). Also, the combinations of starting amines and starting nitrites may be varied. For example, either a monoamine or a diamine may be used in the method of the present invention with either a mononitrile or a dinitrile. Additionally, one or more primary amines may be used with a combination of nitrites; or one or more nitrites with a combination of amines. The use of a combination of nitriles is exemplified in Table 1 below, but is not intended to limit the scope of the invention described herein.
- Suitable catalysts for the present invention comprise the metal elements selected from the group consisting of palladium, rhodium, platinum, and iridium. Preferred catalysts are catalysts comprising palladium. Examples of catalysts comprising palladium include, but are not limited to, palladium black or palladium on a support, wherein the palladium content on the support is between about 0.1 and 10 wt. % loading. The catalyst also can be comprised of mixed metal compositions. For example the catalyst may comprise palladium with between about 0.1 and 10% of at least one additional metal. The preferred elements for the mixed metal compositions to be used with palladium are selected from the group consisting of rhodium, platinum, iridium and ruthenium.
- Other catalyst systems, such as copper oxide-zirconium oxide, which are known to promote single reductive amination reactions can be used also.
- A support material can be used with the catayst of the present invention. Suitable supports include, but are not limited to, activated carbon, silicon carbide and oxidic supports, (for example, alumina, silica, titania, zirconia, magnesia, copper oxide).
- The catalyst can be used in any desired form, including but not limited to extrudate, large granules, pellet, sphere, slurry or dry powder.
- The method of the present invention is carried out under hydrogen pressure of between about 100 and about 1500 psig. Hydrogen pressures between about 500 and 1000 psig are most preferred. The temperature should be maintained between about 50° C. and about 200° C., with about 80° C. to about 130° C. being preferred.
- Solvents are not necessary to carry out the method. However solvents such as water, methanol, ethanol, tertiary-butyl ether, tetrahydrofuran, and N-methylpyrrolidinone and other solvents known to dissolve the starting amine and nitrile compounds are suitable. Also, the present invention may be carried out batchwise or in a continuous reactor. The final alkylated amine product can be purified in a conventional manner.
- The following examples were carried out in batch mode.
- Legend:
- BCPAM means bis(5-cyanopentyl)aminomethane
- ADN means adiponitrile
- To a 300 cc pressure autoclave reactor were charged 2.77 g of 5% Pd/alumina powder catalyst (2.3% or 42:1 nitrile to catalyst), 20.8 g of 40% (w/w) aqueous methylamine (0.27 mol), and 116.0 g of ADN (1.1 mol). The reactor was sealed and purged with nitrogen and hydrogen to remove oxygen. The reaction was conducted at 110° C. under 500 psig of hydrogen. The consumed hydrogen was constantly replenished from a 1-liter vessel. After 120 min the reaction mixture comprised 47% ADN, 41% BCPAM and other products. The selectivity to BCPAM was 79%.
- To a 300 cc pressure autoclave reactor were charged 5.46 g of 5% Pd/alumina powder catalyst, 41.6 g of 40% (w/w) aqueous methylamine (0.54 mol), and 116.0 g of ADN (1.1 mol). The reactor was sealed and purged with nitrogen and hydrogen to remove oxygen. The reaction was conducted at 110° C. under 500 psig of hydrogen. The consumed hydrogen was constantly replenished from a 1-liter vessel. After 575 min the reaction mixture comprised 6% ADN, 67% BCPAM and other products. The selectivity to BCPAM was 72%.
- 116.0 g of adiponitrile and 15.7 mL of propylamine, (4 to 1 ratio of dinitrile to primary amine) were charged to a 300 cc autoclave along with 2.8 grams of catalyst (5 wt. % Pd on alumina powder). After purging with nitrogen, the reaction was pressurized to 50 psig with hydrogen and heating was commenced. Hydrogen was continuously replenished. After the temperature reached 110° C., stirring was increased to 1000 rpm and the hydrogen pressure was increased to 500 psig. The temperature and pressure were maintained for 1.5 hours. The product mixture comprised of 39% bis(cyanopentyl)aminopropane and 36% unconverted adiponitrile.
- Examples 4-8 in Table 1 demonstrate the disclosed method using different or a combination of nitriles with various amines. The examples were carried out in batch mode, using 1 part 5 wt. % Pd/Al2O3 catalyst to 20 parts of starting nitrile; and a hydrogen pressure of 500 psig and a temperature of 100° C. were maintained for 3 hours. The unique tertiary amine products of Examples 4, 6 and 8 were analyzed by IR using a Perkin Elmer 1600 Series Fourier Transform Infrared Instrument and a Hewlett Packard 5971 Series Mass Selective Detector in conjunction with a Hewlett Packard 5890 Series Gas Chromatograph.
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TABLE 1 Ex. No./ Nitrile to Tertiary Tertiary Amine Starting Starting Amine Product Amine Molar Ratio Conv Nitrile Amine IUPAC name Yield 4 86% Hydroxy Methyl- bis(3-hydroxypropyl) 31% 2 to 1 Propionitrile amine aminomethane 5 >99% Acetonitrile Propane- N,N,N′,N′-tetraethyl- 74% 4 to 1 diamine 1,3-propanediamine 6 2% Adiponitrile 2-amino- 3-bis(cyanopentyl) 51% 2 to 1 ethanol amino-ethanol 7 >99% Acetonitrile 1,2-diamino- N,N,N′-triethyl-1,2- 40% 4 to 1 cyclohexane diaminocyclo- hexane 8 95% 1:1 mixture of Methyl- mixture of tertiary 58% 2 to 1 adiponitrile and amine amines, including glutaronitrile cyanobutyl- cyanopentylamino- methane - The examples in Table 2 demonstrate the use of different catalysts in the disclosed method. The following examples were carried out in batch mode, using 1 part catalyst to 20 parts of adiponitrile. The molar ratio of methylamine (40 wt. % aq.) to adiponitrile was 1 to 4 in each case. Hydrogen pressure of 500 psig and temperature of 100° C. were maintained for 3 hours.
TABLE 2 Ex. Catalyst Used Conversions Tertiary Amine Yield 9 5% Pd/Carbon >99% 71% 10 4% Pd/ >99% 58% 1% Pt on Carbon 11 4.5% Pd/ >99% 63% 0.5% Ru on Carbon 12 5% Pd/Titania >99% 75% 13 5% Pt/Carbon 86% 19% 14 5% Rh/Carbon >99% 6% - To a 300 cc pressure autoclave reactor were charged 3.66 g of 5% Pd/alumina powder catalyst, 55.8 g of 40% (w/w) aqueous methylamine (0.72 mol), 77.7 g of adiponitrile (0.72 mol) and 2.3 g biphenyl (internal standard for gas chromatography analysis). The reactor was sealed and purged with nitrogen and hydrogen to remove oxygen. The reaction was conducted at 110° C. under 500 psig of hydrogen. The consumed hydrogen was constantly replenished from a 1-liter vessel. After 240 min an analysis of the crude product mixture comprised 13% adiponitrile, 46% BCPAM. The selectivity was 65%.
- After 300 min the crude product mixture comprised 4% adiponitrile, 52% BCPAM, and other products. The selectivity to BCPAM was 62%.
- To a 300 cc pressure autoclave reactor were charged 2.74 g of 5% Pd/alumina powder catalyst, 83.71 g of 40% (w/w) aqueous methylamine (1.1 mol), 58.3 g of adiponitrile (0.54 mol) and 1.7 g biphenyl (internal standard for gas chromatography analysis). The reactor was sealed and purged with nitrogen and hydrogen to remove oxygen. The reaction was conducted at 110° C. under 500 psig of hydrogen. The consumed hydrogen was constantly replenished from a 1-liter vessel. After 360 min the reaction mixture comprised 12% ADN, 29% BCPAM. The selectivity was 49%. After 410 min the reaction mixture comprised 5% ADN, 31% BCPAM. The selectivity was 44%.
Claims (18)
Priority Applications (17)
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US10/053,073 US6600075B1 (en) | 2001-11-13 | 2001-11-13 | Process for the preparation of tertiaŕy amines from primary amines and nitriles |
EP10179198A EP2264006A1 (en) | 2001-11-13 | 2002-11-05 | Process for the preparation of tertiary amines from primary amines and nitriles |
PCT/US2002/035495 WO2003042134A2 (en) | 2001-11-13 | 2002-11-05 | Process for the preparation of tertiary amines from primary amines and nitriles |
DE60229282T DE60229282D1 (en) | 2001-11-13 | 2002-11-05 | PROCESS FOR THE PREPARATION OF TERTIARY AMINES FROM PRIMARY AMINES AND NITRILES |
CNB028223829A CN100352799C (en) | 2001-11-13 | 2002-11-05 | Process for the preparation of tertiary amines from primary amines and nitriles |
EP07076053.3A EP1900724B1 (en) | 2001-11-13 | 2002-11-05 | Process for the preparation of tertiary amines from primary amines and nitriles |
EP02797064A EP1444193B1 (en) | 2001-11-13 | 2002-11-05 | Process for the preparation of tertiary amines from primary amines and nitriles |
BR0214193-0A BR0214193A (en) | 2001-11-13 | 2002-11-05 | Method for the preparation of tertiary amine, tertiary amine compounds and products |
ES02797064T ES2312656T3 (en) | 2001-11-13 | 2002-11-05 | PROCEDURE FOR THE PREPARATION OF TERTIARY AMINES FROM PRIMARY ANIMAS AND NITRILS. |
CA002466442A CA2466442A1 (en) | 2001-11-13 | 2002-11-05 | Process for the preparation of tertiary amines from primary amines and nitriles |
AU2002361587A AU2002361587A1 (en) | 2001-11-13 | 2002-11-05 | Process for the preparation of tertiary amines from primary amines and nitriles |
ES07076053.3T ES2532673T3 (en) | 2001-11-13 | 2002-11-05 | Process for the preparation of tertiary amines from primary amines and nitriles |
KR1020047007181A KR100943123B1 (en) | 2001-11-13 | 2002-11-05 | Process for the Preparation of Tertiary Amines from Primary Amines and Nitriles |
MXPA04004494A MXPA04004494A (en) | 2001-11-13 | 2002-11-05 | Process for the preparation of tertiary amines from primary amines and nitriles. |
JP2003543974A JP4275533B2 (en) | 2001-11-13 | 2002-11-05 | Process for preparing tertiary amines from primary amines and nitriles |
AT02797064T ATE410405T1 (en) | 2001-11-13 | 2002-11-05 | METHOD FOR PRODUCING TERTIARY AMINES FROM PRIMARY AMINES AND NITRILES |
TW091132887A TWI255262B (en) | 2001-11-13 | 2002-11-08 | Process for the preparation of tertiary amines from primary amines and nitriles |
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US10/053,073 US6600075B1 (en) | 2001-11-13 | 2001-11-13 | Process for the preparation of tertiaŕy amines from primary amines and nitriles |
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US20030135052A1 true US20030135052A1 (en) | 2003-07-17 |
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US (1) | US6600075B1 (en) |
EP (3) | EP2264006A1 (en) |
JP (1) | JP4275533B2 (en) |
KR (1) | KR100943123B1 (en) |
CN (1) | CN100352799C (en) |
AT (1) | ATE410405T1 (en) |
AU (1) | AU2002361587A1 (en) |
BR (1) | BR0214193A (en) |
CA (1) | CA2466442A1 (en) |
DE (1) | DE60229282D1 (en) |
ES (2) | ES2532673T3 (en) |
MX (1) | MXPA04004494A (en) |
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CN115028537A (en) * | 2022-05-26 | 2022-09-09 | 万华化学集团股份有限公司 | Preparation method of aminopropyl alicyclic secondary amine |
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JP4524365B2 (en) * | 2004-02-25 | 2010-08-18 | 財団法人名古屋産業科学研究所 | Method for producing asymmetric aliphatic tertiary amine |
CN102976950A (en) * | 2012-12-18 | 2013-03-20 | 天津天智精细化工有限公司 | Improved process for preparing tertiary amine |
CN104888800B (en) * | 2015-05-12 | 2018-04-27 | 常州鑫邦再生资源利用有限公司 | A kind of preparation method of the Pd/carbon catalyst of composition metal |
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DE3403778A1 (en) * | 1984-02-03 | 1985-08-08 | Degussa Ag, 6000 Frankfurt | CYANOMETHYL- (2-CYANO-ETHYL) - (3-HYDROXY-PROPYL) -AMINE HIS USE FOR PRODUCING 1- (3-HYDROXY-PROPYL) -1,4-DIAZEPANE AND 1,4-BIS (3- (3rd , 4,5-TRIMETHOXYBENZOYLOXY) -PROPYL) -DIAZEPAN |
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JPH0241338A (en) * | 1988-08-01 | 1990-02-09 | Lion Corp | Antifoaming agent for polymer latex |
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US6723799B2 (en) * | 2001-08-24 | 2004-04-20 | E I. Du Pont De Nemours And Company | Acid-dyeable polymer compositions |
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CN115028537A (en) * | 2022-05-26 | 2022-09-09 | 万华化学集团股份有限公司 | Preparation method of aminopropyl alicyclic secondary amine |
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ES2312656T3 (en) | 2009-03-01 |
JP4275533B2 (en) | 2009-06-10 |
EP2264006A1 (en) | 2010-12-22 |
US6600075B1 (en) | 2003-07-29 |
KR20050043787A (en) | 2005-05-11 |
KR100943123B1 (en) | 2010-02-18 |
MXPA04004494A (en) | 2004-08-11 |
WO2003042134A2 (en) | 2003-05-22 |
EP1900724A3 (en) | 2008-03-26 |
EP1900724A2 (en) | 2008-03-19 |
CA2466442A1 (en) | 2003-05-22 |
JP2005511620A (en) | 2005-04-28 |
EP1900724B1 (en) | 2014-12-17 |
EP1444193A4 (en) | 2006-02-15 |
AU2002361587A1 (en) | 2003-05-26 |
TWI255262B (en) | 2006-05-21 |
ATE410405T1 (en) | 2008-10-15 |
EP1444193A2 (en) | 2004-08-11 |
EP1444193B1 (en) | 2008-10-08 |
WO2003042134A3 (en) | 2003-11-20 |
BR0214193A (en) | 2004-08-31 |
CN100352799C (en) | 2007-12-05 |
TW200300135A (en) | 2003-05-16 |
CN1639108A (en) | 2005-07-13 |
ES2532673T3 (en) | 2015-03-30 |
DE60229282D1 (en) | 2008-11-20 |
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