US20020192699A1

US20020192699A1 - Genes and gene expression products that are differentially regulated in prostate cancer

Info

Publication number: US20020192699A1
Application number: US10/202,193
Authority: US
Inventors: Jimmy Zhang; Jon Astle; Eddie Carroll; Wilson Endege; Donna Ford; John Monahan; Robert Schlegel; Kathleen Steinmann
Original assignee: Chiron Corp
Current assignee: Novartis Vaccines and Diagnostics Inc
Priority date: 1998-06-11
Filing date: 2002-07-23
Publication date: 2002-12-19
Also published as: ES2402095T3; WO1999064594A2; JP2002517244A; US6476207B1; WO1999064594A3; EP1086218A2; WO1999064594A8; WO1999064594A9

Abstract

This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The invention further relates to polynucleotides differentially expressed in prostate cancer.

Description

FIELD OF THE INVENTION

This invention relates to the area of diagnosis, prognosis, and treatment of cancer, tumor progression, hyperproliferative cell growth, and accompanying physical and biological manifestations. More specifically, the invention includes polynucleotides that are differentially regulated in prostatic disorders, such as metastatic prostate cancer, localized prostate cancer, and benign prostate hyperplasia (BPH).

BACKGROUND OF THE INVENTION

Genes that are up- or down-regulated in cancer or tumor progression are useful for therapeutic and diagnostic purposes. For example, detection of genes or gene expression products up-regulated in hyperproliferative cells can be a predictive or diagnostic marker of the onset or the progression of cancer. Early diagnosis can be useful if the cancer, tumors, or hyperproliferating cells can be inhibited, removed, or terminated to prevent metastasis or recurrence of cancerous growth. Such early warning is of particular use to prostate cancer patients, where removal of the growth, tumor, or cells is beneficial if the disease is confined to the prostate. There is a need in the art for genes related to cancer and tumor progression.

SUMMARY OF THE INVENTION

The present invention provides methods and reagents for diagnosing cancer, tumor progression, hyperproliferative cell growth, and accompanying biological and physical manifestations. Reagents for such diagnostic kits include:

(a) polynucleotides comprising a sequence capable of hybridizing to one or more of SEQ ID NO:1-339 or complement thereof,

(b) polypeptides comprising the amino acid sequence encoded by any one of SEQ ID NO:1-339; and

(c) antibodies capable of binding polypeptides comprising the amino acid sequence of (b).

The methods of diagnosis of the present invention include both nucleic acid assays and immunoassays.

In another embodiment, the present invention provides both compositions and methods for treating or ameliorating cancer, tumor progression, hyperproliferative cell growth, and accompanying biological and physical manifestations. The compositions for treatment or amelioration include:

(a) polynucleotides comprising the sequence capable of hybridizing to one or more of the sequences shown in SEQ ID NO:1-339 and complement thereof, including antisense, ribozyme and gene therapy nucleic acid constructs;

(c) antibodies capable of binding polypeptides of polypeptides comprising the amino acid sequence (b).

Methods of treatment or amelioration include administering compositions of polynucleotides, polypeptides, antibodies, or combinations thereof and can be used

(a) to inhibit translation and/or transcription;

(b) to inhibit biological activity;

(c) as a vaccine antigen; and

(d) as an immune system inducer.

Such compositions can be administered systemically or locally to the desired site.

In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of

(a) any one of SEQ ID NOs:2, 5, 49, 50, 99, 100, 115, 116, 118, 130, 131, 140, 144, 145, 146, 157, 158, 159, 163, 164, 165, 166, 177, 178, 180, 211, 212, 213, 218, 219, 220, 221, 229, 232, 233, 242, 243, 248, 249, 254, 256, 257, 259, 272, 273, 277, 288, 289, 292, 293, 316, 317, and 330;

(b) a polynucleotide that encodes a variant of the polypeptide encoded by (a); and

(c) a polynucleotide encoding a protein expressed by a polynucleotide having the sequence of any one of the sequences of (a).

Preferably, the nucleic acid obtained from the biological material of part (b) above is genomic DNA or mRNA. The nucleic acid can also be cDNA complementary to the mRNA.

Another embodiment of the invention is the use of the isolated polynucleotides or parts thereof as diagnostic probes or as primers.

In another embodiment, the present invention provides a composition comprising a polypeptide, wherein said polypeptide is selected from the group consisting of

(a) a polypeptide encoded by any one of SEQ ID Nos:2, 5, 49, 50, 99, 100, 115, 116, 118, 130, 131, 140, 144, 145, 146, 157, 158, 159, 163, 164, 165, 166, 177, 178, 180, 211, 212, 213, 218, 219, 220, 221, 229, 232, 233, 242, 243, 248, 249, 254, 256, 257, 259, 272, 273, 277, 288, 289, 292, 293, 316, 317, and 330;

(b) a polypeptide encoded by full-length mRNA or cDNA corresponding to any one of SEQ ID NO:1-339, and

(c) a variant of the protein (a) or (b);

In certain preferred embodiments, the polynucleotide is operably linked to an expression control sequence. The invention further provides a host cell, including bacterial, yeast, insect and mammalian cells, transformed with the polynucleotide sequence. The invention also provides the full-length cDNA and the full length human gene corresponding to the polynucleotide.

Protein and polypeptide compositions of the invention may further comprise a pharmaceutically acceptable carrier. Compositions comprising an antibody that specifically reacts with such protein or polypeptide are also provided by the present invention.

The invention further relates to a polypeptide or nucleic acid obtained by transforming a host cell with nucleic acid comprising at least one of SEQ ID NO:1-339, culturing the host cell, and recovering the replicated nucleic acid, the expressed RNA, and/or the expressed polypeptide.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 provides the open reading frame for clone SL 195. [0031]
FIG. 2 provides the open reading frame for clone SL 197. [0032]
FIG. 3 provides the immunohistochemistry staining results for clone SL expression in a variety of normal and tumor tissues.[0033]

DETAILED DESCRIPTION OF THE INVENTION

Genes that are up- or down-regulated in cancer or tumor progression are useful for therapeutic and diagnostic purposes. For example, a diagnostic assay to determine the stage of the disease also is useful in tailoring treatment of aggressive versus more mild cancer or tumor progression. The polynucleotide sequences and encoded polypeptides of the present invention are useful for these diagnostic or prognostic purposes. [0034]
Further, modulation of genes or gene expression products that are misregulated can be used to treat or ameliorate cancer, tumor progression, hyperproliferative cell growth, and the accompanying physical and biological manifestations. For example, the polynucleotide sequences provided herein as SEQ ID NO:1-339, can be used to construct the following polynucleotide and polypeptide compositions that are useful for treatment: antisense; ribozymes; antibodies; vaccine antigens; and immune system inducers, to induce dendritic cells, for example. [0035]
Identified herein are polynucleotide sequences that are upregulated in a cancer cell line, more specifically in a prostate cancer cell line. Thus, the present invention relates to methods and reagents for diagnosis, and to methods and compositions for treatment. [0036]
I. Use of Polynucleotides Having a Sequence of One or More of SEQ ID NO:1-339 to Obtain Full-Length cDNA and Full-Length Human Gene and Promoter Region [0037]
Full-length cDNA molecules comprising the disclosed sequences are obtained as follows. The polynucleotide or a portion thereof comprising at least 12, 15, 18, or 20 nucleotides is used as a hybridization probe to detect hybridizing members of a cDNA library using probe design methods, cloning methods, and clone selection techniques as described in U.S. Pat. No. 5,654,173, “Secreted Proteins and Polynucleotides Encoding Them,” incorporated herein by reference. Libraries of cDNA are made from selected tissues, such as normal or tumor tissue, or from tissues of a mammal treated with, for example, a pharmaceutical agent. Preferably, the tissue is the same as that used to generate the polynucleotides, as both the polynucleotides and the cDNA represent expressed genes. Most preferably, the cDNA library is made from the biological material described herein in the Examples. Alternatively, many cDNA libraries are available commercially. (Sambrook et al., [0038] Molecular Cloning: A Laboratory Manual, 2nd Ed. (Cold Spring Harbor Press, Cold Spring Harbor, N.Y. 1989).
Members of the library that are larger than the polynucleotide, and preferably that contain the whole sequence of the native message, are obtained. In order to confirm that the entire cDNA has been obtained, RNA protection experiments are performed as follows. Hybridization of a full-length cDNA to an mRNA will protect the RNA from RNase degradation. If the cDNA is not full length, then the portions of the mRNA that are not hybridized will be subject to RNase degradation. This is assayed, as is known in the art, by changes in electrophoretic mobility on polyacrylamide gels, or by detection of released monoribonucleotides. Sambrook et al., [0039] Molecular Cloning: A Laboratory Manual, 2nd Ed. (Cold Spring Harbor Press, Cold Spring Harbor, N.Y. 1989). In order to obtain additional sequences 5′ to the end of a partial cDNA, 5′ RACE (PCR Protocols: A Guide to Methods and Applications (Academic Press, Inc. 1990)) is performed.
Genomic DNA is isolated using polynucleotides in a manner similar to the isolation of full-length cDNAs. Briefly, the polynucldotides, or portions thereof, are used as probes to libraries of genomic DNA. Preferably, the library is obtained from the cell type that was used to generate the polynucleotides, but this is not essential. Most preferably, the genomic DNA is obtained from the biological material described herein in the Examples. Such libraries may be in vectors suitable for carrying large segments of a genome, such as P1 or YAC, as described in detail in Sambrook et al., 9.4-9.30. In addition, genomic sequences can be isolated from human BAC libraries, which are commercially available from Research Genetics, Inc., Huntville, Ala., USA, for example. In order to obtain additional 5′ or 3′ sequences, chromosome walking is performed, as described in Sambrook et al., such that adjacent and overlapping fragments of genomic DNA are isolated. These are mapped and pieced together, as is known in the art, using restriction digestion enzymes and DNA ligase. [0040]
Using the polynucleotides sequences of the invention, corresponding full length genes can be isolated using both classical and PCR methods to construct and probe cDNA libraries. Using either method, Northern blots, preferably, are performed on a number of cell types to determine which cell lines express the gene of interest at the highest rate. [0041]
Classical methods of constructing cDNA libraries are taught in Sambrook et al., supra. With these methods, cDNA can be produced from mRNA and inserted into viral or expression vectors. Typically, libraries of mRNA comprising poly(A) tails can be produced with poly(T) primers. Similarly, cDNA libraries can be produced using the instant sequences as primers. [0042]
PCR methods are used to amplify the members of a cDNA library that comprise the desired insert. In this case, the desired insert will contain sequence from the full length cDNA that corresponds to the instant ESTs. Such PCR methods include gene trapping and RACE methods. Gruber et al., PCT WO 95/04745 and Gruber et al., U.S. Pat. No. 5,500,356. Kits are commercially available to perform gene trapping experiments from, for example, Life Technologies, Gaithersburg, Md., USA. PCT Pub. No. WO 97/19110. (Apte and Siebert, [0043] Biotechniques 15:890-893, 1993; Edwards et al., Nuc. Acids Res. 19:5227-5232, 1991).
The promoter region of a gene generally is located 5′ to the initiation site for RNA polymerase II, and can be obtained by performing 5′ RACE using a primer from the coding region of the gene. Alternatively, the cDNA can be used as a probe for the genomic sequence, and the [0044] region 5′ to the coding region is identified by “walking up.” If the gene is highly expressed or differentially expressed, the promoter from the gene may be of use in a regulatory construct for a heterologous gene.
Once the full-length cDNA or gene is obtained, DNA encoding variants can be prepared by site-directed mutagenesis, described in detail in Sambrook et al., 15.3-15.63. The choice of codon or nucleotide to be replaced can be based on disclosure herein on optional changes in amino acids to achieve altered protein structure and/or function. [0045]
As an alternative method to obtaining DNA or RNA from a biological material, nucleic acid comprising nucleotides having the sequence of one or more polynucleotides of the invention can be synthesized. Thus, the invention encompasses nucleic acid molecules ranging in length from 15 nucleotides (corresponding to at least 15 contiguous nucleotides of one of SEQ ID NO:1-339) up to a maximum length suitable for one or more biological manipulations, including replication and expression, of the nucleic acid molecule. The invention includes but is not limited to (a) nucleic acid having the size of a full gene, and comprising at least one of SEQ ID NO:1-339; (b) the nucleic acid of (a) also comprising at least one additional gene, operably linked to permit expression of a fusion protein; (c) an expression vector comprising (a) or (b); (d) a plasmid comprising (a) or (b); and (e) a recombinant viral particle comprising (a) or (b). [0046]
The sequence of a nucleic acid comprising at least 15 contiguous nucleotides of at least any one of SEQ ID NO 1-339, preferably the entire sequence of at least any one of SEQ ID NO:1-339, is not limited and can be any sequence of A, T, G, and/or C (for DNA) and A, U, G, and/or C (for RNA) or modified bases thereof, including inosine and pseudouridine. The choice of sequence will depend on the desired function and can be dictated by coding regions desired, the intron-like regions desired, and the regulatory regions desired. [0047]
Where the entire sequence of any one of SEQ ID NO:1-339 is within the nucleic acid, the nucleic acid obtained is referred to herein as a polynucleotide comprising the sequence of any one of SEQ ID NO:1-339. [0048]
II. Expression of Polypeptide Encoded by Full-Length cDNA or Full-Length Gene [0049]
The polynucleotide, the corresponding cDNA, or the full-length gene is used to express the partial or complete gene product. Appropriate polynucleotide constructs are purified using standard recombinant DNA techniques as described in, for example, Sambrook et al., (1989) [0050] Molecular Cloning: A Laboratory Manual, 2nd ed. (Cold Spring Harbor Press, Cold Spring Harbor, N.Y.). The polypeptides encoded by the polynucleotides are expressed in any expression system, including, for example, bacterial, yeast, insect, amphibian and mammalian systems. Suitable vectors and host cells are described in U.S. Pat. No. 5,654,173.
Bacteria [0051]
Expression systems in bacteria include those described in Chang et al., [0052] Nature (1978) 275:615, Goeddel et al., Nature (1979) 281:544, Goeddel et al., Nucleic Acids Res. (1980) 8:4057; EP 0 036,776, U.S. Pat. No. 4,551,433, DeBoer et al., Proc. Natl. Acad. Sci. (USA) (1983) 80:21-25, and Siebenlist et al., Cell (1980) 20:269.
Yeast. [0053]
Expression systems in yeast include those described in Hinnen et al, [0054] Proc. Natl. Acad. Sci. (USA) (1978) 75:1929; Ito et al., J. Bacteriol. (1983) 153:163; Kurtz et al., Mol. Cell. Biol. (1986) 6:142; Kunze et al, J. Basic Microbiol. (1985) 25:141; Gleeson et al., J. Gen. Microbiol. (1986) 132:3459, Roggenkamp et al., Mol. Gen. Genet. (1986) 202:302) Das et al., J. Bacteriol. (1984) 158:1165; De Louvencourt et al., J. Bacteriol. (1983) 154:737, Van den Berg et al., Bio/Technology (1990) 8:135; Kunze et al., J. Basic Microbiol. (1985) 25:141, Cregg et al., Mol. Cell. Biol. (1985) 5:3376, U.S. Pat. Nos. 4,837,148 and 4,929,555; Beach and Nurse, Nature (1981) 300:706; Davidow et al., Curr. Genet. (1985) 10:380, Gaillardin et al., Curr. Genet. (1985) 10:49, Ballance et al., Biochem. Biophys. Res. Commun. (1983) 112:284-289; Tilbum et al., Gene (1983) 26:205-221, Yelton et al., Proc. Natl. Acad. Sci. (USA) (1984) 81:1470-1474, Kelly and Hynes, EMBO J. (1985) 4:475479; EP 0 244,234, and WO 91/00357.
Insect Cells. [0055]
Expression of heterologous genes in insects is accomplished as described in U.S. Pat. No. 4,745,051, Friesen et al. (1986) “The Regulation of Baculovirus Gene Expression” in: The Molecular Biology Of Baculoviruses (W. Doerfler, ed.), EP 0 127,839, EP 0 155,476, and Vlak et al., J. Gen. Virol. (1988) 69:765-776, Miller et al., [0056] Ann. Rev. Microbiol. (1988) 42:177, Carbonell et al., Gene (1988) 73:409, Maeda et al., Nature (1985) 315:592-594, Lebacq-Verheyden et al, Mol. Cell Biol. (1988) 8:3129; Smith et al., Proc. Natl. Acad. Sci. (USA) (1985) 82:8404, Miyajima et al., Gene (1987) 58:273; and Martin et al., DNA (1988) 7:99. Numerous baculoviral strains and variants and corresponding permissive insect host cells from hosts are described in Luckow et al., Bio/Technology (1988) 6:47-55, Miller et al., Generic Engineering (Setlow, J. K. et al. eds.), Vol. 8 (Plenum Publishing, 1986), pp. 277-279, and Maeda et al., Nature, (1985) 315:592-594.
Mammalian Cells. [0057]
Mammalian expression is accomplished as described in Dijkema et al., [0058] EMBO J. (1985) 4:761, Gorman et al., Proc. Natl. Acad. Sci. (USA) (1982) 79:6777, Boshart et al., Cell (1985) 41:521 and U.S. Pat. No. 4,399,216. Other features of mammalian expression are facilitated as described in Ham and Wallace, Meth. Enz. (1979) 58:44, Barnes and Sato, Anal. Biochem. (1980) 102:255, U.S. Pat. Nos. 4,767,704, 4,657,866, 4,927,762, 4,560,655, WO 90/103430, WO 87/00195, and U.S. RE 30,985.
Polynucleotide molecules comprising the polynucleotide sequence are propagated by placing the molecule in a vector. Viral and non-viral vectors are used, including plasmids. The choice of plasmid will depend on the type of cell in which propagation is desired and the purpose of propagation. Certain vectors are useful for amplifying and making large amounts of the desired DNA sequence. Other vectors are suitable for expression in cells in culture. Still other vectors are suitable for transfer and expression in cells in a whole animal or person. The choice of appropriate vector is well within the skill of the art. Many such vectors are available commercially. The polynucleotide is inserted into a vector typically by means of DNA ligase attachment to a cleaved restriction enzyme site in the vector. Alternatively, the desired nucleotide sequence may be inserted by homologous recombination in vivo. Typically this is accomplished by attaching regions of homology to the vector on the flanks of the desired nucleotide sequence. Regions of homology are added by ligation of oligonucleotides, or by polymerase chain reaction using primers comprising both the region of homology and a portion of the desired nucleotide sequence, for example. [0059]
Polynucleotides are linked to regulatory sequences as appropriate to obtain the desired expression properties. These may include promoters (attached either at the 5′ end of the sense strand or at the 3′ end of the antisense strand), enhancers, terminators, operators, repressors, and inducers. The promoters may be regulated or constitutive. In some situations it may be desirable to use conditionally active promoters, such as tissue-specific or developmental stage-specific promoters. These are linked to the desired nucleotide sequence using the techniques described above for linkage to vectors. Any techniques known in the art may be used. [0060]
When any of the above host cells, or other appropriate host cells or organisms, are used to replicate and/or express the polynucleotides or nucleic acids of the invention, the resulting replicated nucleic acid, RNA, expressed protein or polypeptide, is within the scope of the invention as a product of the host cell or organism. The product is recovered by any appropriate means known in the art. [0061]
Once the gene corresponding to the polypeptide is identified, its expression can be regulated in the cell to which the gene is native. For example, an endogenous gene of a cell can be regulated by an exogenous regulatory sequence as disclosed in U.S. Pat. No. 5,641,670, “Protein Production and Protein Delivery.”[0062]
Ribozymes [0063]
Trans-cleaving catalytic RNAs (ribozymes) are RNA molecules possessing endoribonuclease activity. Ribozymes are specifically designed for a particular target, and the target message must contain a specific nucleotide sequence. They are engineered to cleave any RNA species site-specifically in the background of cellular RNA. The cleavage event renders the mRNA unstable and prevents protein expression. Importantly, ribozymes can be used to inhibit expression of a gene of unknown function for the purpose of determining its function in an in vitro or in vivo context, by detecting the phenotypic effect. [0064]
One commonly used ribozyme motif is the hammerhead, for which the substrate sequence requirements are minimal. Design of the hammerhead ribozyme is disclosed in Usman et al., [0065] Current Opin. Struct. Biol. (1996) 6:527-533. Usman also discusses the therapeutic uses of ribozymes. Ribozymes can also be prepared and used as described in Long et al., FASEB J. (1993) 7:25; Symons, Ann. Rev. Biochem. (1992) 61:641; Perrotta et al., Biochem. (1992) 31:16-17; Ojwang et al., Proc. Natl. Acad. Sci. (USA) (1992) 89:10802-10806; and U.S. Pat. No. 5,254,678. Ribozyme cleavage of HIV-1 RNA is described in U.S. Pat. No. 5,144,019; methods of cleaving RNA using ribozymes is described in U.S. Pat. No. 5,116,742; and methods for increasing the specificity of ribozymes are described in U.S. Pat. No. 5,225,337 and Koizumi et al., Nucleic Acid Res. (1989) 17:7059-7071. Preparation and use of ribozyme fragments in a hammerhead structure are also described by Koizumi et al., Nucleic Acids Res. (1989) 17:7059-7071. Preparation and use of ribozyme fragments in a hairpin structure are described by Chowrira and Burke, Nucleic Acids Res. (1992) 20:2835. Ribozymes can also be made by rolling transcription as described in Daubendiek and Kool, Nat. Biotechnol. (1997) 15(3):273-277.
The hybridizing region of the ribozyme may be modified or may be prepared as a branched structure as described in Horn and Urdea, [0066] Nucleic Acids Res. (1989) 17:6959-67. The basic structure of the ribozymes may also be chemically altered in ways familiar to those skilled in the art, and chemically synthesized ribozymes can be administered as synthetic oligonucleotide derivatives modified by monomeric units. In a therapeutic context, liposome mediated delivery of ribozymes improves cellular uptake, as described in Birikh et al., Eur. J. Biochem. (1997) 245:1-16.
Therapeutic and functional genomic applications of ribozymes proceed beginning with knowledge of a portion of the coding sequence of the gene to be inhibited. Thus, for many genes, a polynucleotide sequence as disclosed herein provides adequate sequence for constructing an effective ribozyme. A target cleavage site is selected in the target sequence, and a ribozyme is constructed based on the 5′ and 3′ nucleotide sequences that flank the cleavage site. Retroviral vectors are engineered to express monomeric and multimeric hammerhead ribozymes targeting the mRNA of the target coding sequence. These monomeric and multimeric ribozymes are tested in vitro for an ability to cleave the target mRNA. A cell line is stably transduced with the retroviral vectors expressing the ribozymes, and the transduction is confirmed by Northern blot analysis and reverse-transcription polymerase chain reaction (RT-PCR). The cells are screened for inactivation of the target mRNA by such indicators as reduction of expression of disease markers or reduction of the gene product of the target mRNA. [0067]
Antisense [0068]
Antisense nucleic acids are designed to specifically bind to RNA, resulting in the formation of RNA-DNA or RNA-RNA hybrids, with an arrest of DNA replication, reverse transcription or messenger RNA translation. Antisense polynucleotides based on a selected sequence can interfere with expression of the corresponding gene. Antisense polynucleotides are typically generated within the cell by expression from antisense constructs that contain the antisense EST strand as the transcribed strand. Antisense polynucleotides will bind and/or interfere with the translation of the corresponding mRNA. The expression products of control cells and cells treated with the antisense construct are compared to detect the protein product of the gene corresponding to the polynucleotide. The protein is isolated and identified using routine biochemical methods. [0069]
Antisense therapy for a variety of cancers is in clinical phase and has been discussed extensively in the literature. Reed reviewed antisense therapy directed at the Bc1-2 gene in tumors; gene transfer-mediated overexpression of Bc1-2 in tumor cell lines conferred resistance to many types of cancer drugs. (Reed, J. C., N. C. I. (1997) 89:988-990). The potential for clinical development of antisense inhibitors of ras is discussed by Cowsert, L. M., [0070] Anti-Cancer Drug Design (1997) 12:359-371. Additional important antisense targets include leukemia (Geurtz, A. M., Anti-Cancer Drug Design (1997) 12:341-358); human C-ref kinase (Monia, B. P., Anti-Cancer Drug Design (1997) 12:327-339); and protein kinase C (McGraw et al., Anti-Cancer Drug Design (1997) 12:315-326.
Given the extensive background literature and clinical experience in antisense therapy, one skilled in the art can use selected polynucleotides of the invention as additional potential therapeutics. The choice of polynucleotide can be narrowed by first testing them for binding to “hot spot” regions of the genome of cancerous cells. If a polynucleotide is identified as binding to a “hot spot”, testing the polynucleotide as an antisense compound in the corresponding cancer cells clearly is warranted. [0071]
Ogunbiyi et al., [0072] Gastroenterology (1997) 113(3):761-766 describe prognostic use of allelic loss in colon cancer; Barks et al., Genes, Chromosomes, and Cancer (1997) 19(4):278-285 describe increased chromosome copy number detected by FISH in malignant melanoma; Nishizake et al., Genes, Chromosomes, and Cancer (1997) 19(4):267-272 describe genetic alterations in primary breast cancer and their metastases and direct comparison using modified comparative genome hybridization; and Elo et al., Cancer Research (1997) 57(16):3356-3359 disclose that loss of heterozygosity at 16z24.1-q24.2 is significantly associated with metastatic and aggressive behavior of prostate cancer.
Dominant Negative Mutations [0073]
Dominant negative mutations are readily generated for corresponding proteins that are active as homomultimers. A mutant polypeptide will interact with wild-type polypeptides (made from the other allele) and form a non-functional multimer. Thus, a mutation is in a substrate-binding domain, a catalytic domain, or a cellular localization domain. Preferably, the mutant polypeptide will be overproduced. Point mutations are made that have such an effect. In addition, fusion of different polypeptides of various lengths to the terminus of a protein can yield dominant negative mutants. General strategies are available for making dominant negative mutants. See Herskowitz, [0074] Nature (1987) 329:219-222. Such a technique can be used for creating a loss of function mutation, which is useful for determining the function of a protein.
Identification of Secreted and Membrane-Bound Polypeptides [0075]
Both secreted and membrane-bound polypeptides of the present invention are of interest. For example, levels of secreted polypeptides can be assayed conveniently in body fluids, such as blood, urine, prostatic fluid and semen. Membrane-bound polypeptides are useful for constructing vaccine antigens or inducing an immune response. Such antigens would comprise all or part of the extracellular region of the membrane-bound polypeptides. [0076]
Because both secreted and membrane-bound polypeptides comprise a fragment of contiguous hydrophobic amino acids, hydrophobicity predicting algorithms can be used to identify such polypeptides. [0077]
A signal sequence is usually encoded by both secreted and membrane-bound polypeptide genes to direct a polypeptide to the surface of the cell. The signal sequence usually comprises a stretch of hydrophobic residues. Such signal sequences can fold into helical structures. [0078]
Membrane-bound polypeptides typically comprise at least one transmembrane region that possesses a stretch of hydrophobic amino acids that can transverse the membrane. Some transmembrane regions also exhibit a helical structure. [0079]
Hydrophobic fragments within a polypeptide can be identified by using computer algorithms. Such algorithms include Hopp & Woods, [0080] Proc. Natl. Acad. Sci. USA 78: 3824-3828 (1981); Kyte & Doolittle, J. Mol Biol. 157 105-132 (1982); and RAOAR algorithm, Degli Esposti et al., Eur. J. Biochem. 190: 207-219 (1990).
Another method of identifying secreted and membrane-bound polypeptides is to translate the present polynucleotides, SEQ ID NO:1-339, in all six frames and determine if at least 8 contiguous hydrophobic amino acids are present. Those translated polypeptides with at least 8; more typically, 10; even more typically, 12 contiguous hydrophobic amino acids are considered to be either a putative secreted or membrane bound polypeptide. Hydrophobic amino acids include alanine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, threonine, tryptophan, tyrosine, and valine. [0081]
Putative secreted and/or membrane-bound polypeptides are encoded by the sequences of the following clones: SL-5, SL-6, SL-9, SL-11, SL-13, SL-90, SL-100, SL-107, SL-124, SL-135, SL-139, SL-143, SL-152, SL-153, SL-173, and SL-177. [0082]
Construction of Polypeptides of the Invention and Variants Thereof [0083]
The polypeptides of the invention include those encoded by the disclosed polynucleotides. These polypeptides can also be encoded by nucleic acids that, by virtue of the degeneracy of the genetic code, are not identical in sequence to the disclosed polynucleotides. Thus, the invention includes within its scope nucleic acids comprising polynucleotides encoding a protein or polypeptide expressed by a polynucleotide having the sequence of any one of SEQ ID NO:1-339. Also within the scope of the invention are variants; variants of polypeptides include mutants, fragments, and fusions. Mutants can include amino acid substitutions, additions or deletions. The amino acid substitutions can be conservative amino acid substitutions or substitutions to eliminate non-essential amino acids, such as to alter a glycosylation site, a phosphorylation site or an acetylation site, or to minimize misfolding by substitution or deletion of one or more cysteine residues that are not necessary for function. Conservative amino acid substitutions are those that preserve the general charge, hydrophobicity/hydrophilicity, and/or steric bulk of the amino acid substituted. For example, substitutions between the following groups are conservative: Gly/Ala, Val/Ile/Leu, Asp/Glu, Lys/Arg, Asn/Gln, Ser/Cys,Thr, and Phe/Trp/Tyr. [0084]
Cysteine-depleted muteins are variants within the scope of the invention. These variants can be constructed according to methods disclosed in U.S. Pat. No. 4,959,314, “Cysteine-Depleted Muteins of Biologically Active Proteins.” The patent discloses how to substitute other amino acids for cysteines, and how to determine biological activity and effect of the substitution. Such methods are suitable for proteins according to this invention that have cysteine residues suitable for such substitutions, for example to eliminate disulfide bond formation. [0085]
The protein variants described herein are encoded by polynucleotides that are within the scope of the invention. The genetic code can be used to select the appropriate codons to construct the corresponding variants. [0086]
The invention encompasses polynucleotide sequences having at least 65% sequence identity to any one of SEQ ID NOs:1-339 as determined by the Smith-Waterman homology search algorithm as implemented in MSPRCH program (Oxford Molecular) using an affine gap search with the following search parameters: gap open penalty of 12, and gap extension penalty of 1. [0087]
Use of the Polynucleotides as Probes. in Mapping, and in Tissue Profiling [0088]
Probes [0089]
Polynucleotide probes comprising at least 12 contiguous nucleotides selected from the nucleotide sequence of a polynucleotide of SEQ ID NO:1-339 are used for a variety of purposes, including identification of human chromosomes and determining transcription levels. [0090]
The nucleotide probes are labeled, for example, with a radioactive, fluorescent, biotinylated, or chemiluminescent label, and detected by well known methods appropriate for the particular label selected. Protocols for hybridizing nucleotide probes to preparations of metaphase chromosomes are also well known in the art. A nucleotide probe will hybridize specifically to nucleotide sequences in the chromosome preparations which are complementary to the nucleotide sequence of the probe. A probe that hybridizes specifically to a polynucleotide should provide a detection signal at least 5-, 10-, or 20-fold higher than the background hybridization provided with other unrelated sequences. [0091]
In a non-limiting example, commercial programs are available for identifying regions of chromosomes commonly associated with disease, such as cancer. Polynucleotides of the invention can be used to probe these regions. For example, if through profile searching a polynucleotide is identified as corresponding to a gene encoding a kinase, its ability to bind to a cancer-related chromosomal region will suggest its role as a kinase in one or more stages of tumor cell development/growth. Although some experimentation would be required to elucidate the role, the polynucleotide constitutes a new material for isolating a specific protein that has potential for developing a cancer diagnostic or therapeutic. [0092]
Nucleotide probes are used to detect expression of a gene corresponding to the polynucleotide. For example, in Northern blots, mRNA is separated electrophoretically and contacted with a probe. A probe is detected as hybridizing to an mRNA species of a particular size. The amount of hybridization is quantitated to determine relative amounts of expression, for example under a particular condition. Probes are also used to detect products of amplification by polymerase chain reaction. The products of the reaction are hybridized to the probe and hybrids are detected. Probes are used for in situ hybridization to cells to detect expression. Probes can also be used in vivo for diagnostic detection of hybridizing sequences. Probes are typically labeled with a radioactive isotope. Other types of detectable labels may be used such as chromophores, fluors, and enzymes. [0093]
Expression of specific mRNA can vary in different cell types and can be tissue specific. This variation of mRNA levels in different cell types can be exploited with nucleic acid probe assays to determine tissue types. For example, PCR, branched DNA probe assays, or blotting techniques utilizing nucleic acid probes substantially identical or complementary to polynucleotides listed in the Sequence Listing can determine the presence or absence of cDNA or mRNA related to the polynucleotides of the invention. [0094]
Examples of a nucleotide hybridization assay are described in Urdea et al., PCT WO92/02526 and Urdea et al., U.S. Pat. No. 5,124,246, both incorporated herein by reference. The references describe an example of a sandwich nucleotide hybridization assay. [0095]
Alternatively, the Polymerase Chain Reaction (PCR) is another means for detecting small amounts of target nucleic acids, as described in Mullis et al., [0096] Meth. Enzymol. (1987) 155:335-350; U.S. Pat. No. 4,683,195; and U.S. Pat. No. 4,683,202, all incorporated herein by reference. Two primer polynucleotides nucleotides hybridize with the target nucleic acids and are used to prime the reaction. The primers may be composed of sequence within or 3′ and 5′ to the polynucleotides of the Sequence Listing. Alternatively, if the primers are 3′ and 5′ to these polynucleotides, they need not hybridize to them or the complements. A thermostable polymerase creates copies of target nucleic acids from the primers using the original target nucleic acids as a template. After a large amount of target nucleic acids is generated by the polymerase, it is detected by methods such as Southern blots. When using the Southern blot method, the labeled probe will hybridize to a polynucleotide of the Sequence Listing or complement.
Furthermore, mRNA or cDNA can be detected by traditional blotting techniques described in Sambrook et al., “Molecular Cloning: A Laboratory Manual” (New York, Cold Spring Harbor Laboratory, 1989). mRNA or cDNA generated from mRNA using a polymerase enzyme can be purified and separated using gel electrophoresis The nucleic acids on the gel are then blotted onto a solid support, such as nitrocellulose. The solid support is exposed to a labeled probe and then washed to remove any unhybridized probe. Next, the duplexes containing the labeled probe are detected. Typically, the probe is labeled with radioactivity. [0097]
Mapping [0098]
Polynucleotides of the present invention are used to identify a chromosome on which the corresponding gene resides. Using fluorescence in situ hybridization (FISH) on normal metaphase spreads, comparative genomic hybridization allows total genome assessment of changes in relative copy number of DNA sequences. See Schwartz and Samad, [0099] Current Opinions in Biotechnology (1994) 8:70-74; Kallioniemi et al., Seminars in Cancer Biology (1993) 4 41-46; Valdes and Tagle, Methods in Molecular Biology (1997) 68:1, Boultwood, ed., Human Press, Totowa, N.J.
Preparations of human metaphase chromosomes are prepared using standard cytogenetic techniques from human primary tissues or cell lines. Nucleotide probes comprising at least 12 contiguous nucleotides selected from the nucleotide sequence shown in the Sequence Listing are used to identify the corresponding chromosome. The nucleotide probes are labeled, for example, with a radioactive, fluorescent, biotinylated, or chemiluminescent label, and detected by well known methods appropriate for the particular label selected. Protocols for hybridizing nucleotide probes to preparations of metaphase chromosomes are also well known in the art. A nucleotide probe will hybridize specifically to nucleotide sequences in the chromosome preparations that are complementary to the nucleotide sequence of the probe. A probe that hybridizes specifically to a polynucleotide-related gene provides a detection signal at least 5-, 10-, or 20-fold higher than the background hybridization provided with non-EST coding sequences. [0100]
Polynucleotides are mapped to particular chromosomes using, for example, radiation hybrids or chromosome-specific hybrid panels. See Leach et al., [0101] Advances in Genetics, (1995) 33:63-99; Walter et al., Nature Genetics (1994) 7:22-28; Walter and Goodfellow, Trends in Genetics (1992) 9:352. Such mapping can be useful in identifying the function of the polynucleotide-related gene by its proximity to other genes with known function. Function can also be assigned to the related gene when particular syndromes or diseases map to the same chromosome.
Tissue Profiling [0102]
The polynucleotides of the present invention can be used to determine the tissue type from which a given sample is derived. For example, a metastatic lesion is identified by its developmental organ or tissue source by identifying the expression of a particular marker of that organ or tissue. If a polynucleotide is expressed only in a specific tissue type, and a metastatic lesion is found to express that polynucleotide, then the developmental source of the lesion has been identified. Expression of a particular polynucleotide is assayed by detection of either the corresponding mRNA or the protein product. Immunological methods, such as antibody staining, are used to detect a particular protein product. Hybridization methods may be used to detect particular mRNA species, including but not limited to in situ hybridization and Northern blotting. [0103]
Use of Polymorphisms [0104]
A polynucleotide will be useful in forensics, genetic analysis, mapping, and diagnostic applications if the corresponding region of a gene is polymorphic in the human population. A particular polymorphic form of the polynucleotide may be used to either identify a sample as deriving from a suspect or rule out the possibility that the sample derives from the suspect. Any means for detecting a polymorphism in a gene are used, including but not limited to electrophoresis of protein polymorphic variants, differential sensitivity to restriction enzyme cleavage, and hybridization to an allele-specific probe. [0105]
Use of Polynucleotides to Raise Antibodies [0106]
Expression products of a polynucleotide, the corresponding mRNA or cDNA, or the corresponding complete gene are prepared and used for raising antibodies for experimental, diagnostic, and therapeutic purposes. The polynucleotide or related cDNA is expressed as described above, and antibodies are prepared. These antibodies are specific to an epitope on the polynucleotide-encoded polypeptide, and can precipitate or bind to the corresponding native protein in a cell or tissue preparation or in a cell-free extract of an in vitro expression system. [0107]
Immunogens for raising antibodies are prepared by mixing the polypeptides encoded by the polynucleotide of the present invention with adjuvants. Alternatively, polypeptides are made as fusion proteins to larger immunogenic proteins. Polypeptides are also covalently linked to other larger immunogenic proteins, such as keyhole limpet hemocyanin. Immunogens are typically administered intradermally, subcutaneously, or intramuscularly. Immunogens are administered to experimental animals such as rabbits, sheep, and mice, to generate antibodies. Optionally, the animal spleen cells are isolated and fused with myeloma cells to form hybridomas which secrete monoclonal antibodies. Such methods are well known in the art. According to another method known in the art, the polynucleotide is administered directly, such as by intramuscular injection, and expressed in vivo. The expressed protein generates a variety of protein-specific immune responses, including production of antibodies, comparable to administration of the protein. [0108]
Preparations of polyclonal and monoclonal antibodies specific for polynucleotide-encoded proteins and polypeptides are made using standard methods known in the art. The antibodies specifically bind to epitopes present in the polypeptides encoded by polynucleotides disclosed in the Sequence Listing. Typically, at least 6, 8, 10, or 12 contiguous amino acids are required to form an epitope. However, epitopes which involve non-contiguous amino acids may require more, for example at least 15, 25, or 50 amino acids. A short sequence of a polynucleotide may then be unsuitable for use as an epitope to raise antibodies for identifying the corresponding novel protein, because of the potential for cross-reactivity with a known protein. However, the antibodies may be useful for other purposes, particularly if they identify common structural features of a known protein and a novel polypeptide encoded by a polynucleotide of the invention. [0109]
Antibodies that specifically bind to human polynucleotide-encoded polypeptides should provide a detection signal at least 5-, 10-, or 20-fold higher than a detection signal provided with other proteins when used in Western blots or other immunochemical assays. Preferably, antibodies that specifically bind polypeptides do not detect other proteins in immunochemical assays and can immunoprecipitate EST-encoded proteins from solution. For such immunoassays, any type of samples can be used, including tissue, organs, cells, urine, blood, prostatic fluid or semen. [0110]
Of interest are antibodies to the secreted polypeptides encoded by the present polynucleotide sequences, SEQ ID NO:1-339. Antibodies to secreted polypeptides can be used to test body fluids, such as blood, urine, prostatic fluid and semen. [0111]
To test for the presence of serum antibodies to the polypeptide in a human population, human antibodies are purified by methods well known in the art. Preferably, the antibodies are affinity purified by passing antiserum over a column to which a protein, polypeptide, or fusion protein is bound. The bound antibodies can then be eluted from the column, for example using a buffer with a high salt concentration. [0112]
In addition to the antibodies discussed above, genetically engineered antibody derivatives are made, such as single chain antibodies or humanized antibodies. [0113]
Antibodies to the polypeptides encoded by one or more of SEQ ID NO:1-339 also are contemplated for therapeutic compositions and uses. For example, antibodies directed to membrane-bound polypeptides that are up-regulated in cancer, tumor progression, hyperproliferative growth, and/or accompanying biological or physical manifestations can be constructed. Antibodies can provide a useful therapeutic in inhibiting cell growth or inducing an immune reaction to cancer, tumor, or hyperproliferating cells. Typically, such antibodies are directed the extracellular regions of the membrane-bound polypeptide. The borders of such regions can be determined by identifying the location of the hydrophobic transmembrane fragment(s) in the encoded polypeptides of the present invention. [0114]
Exemplary antibodies were prepared using two sequences from clone SL-5: H[0115] ₂N-CGPRLPSFPCPTHEPSTGQLSK-CONH₂and H₂N-CKDSQGLSDFKR-NSRTTRRSYKCCONH₂. Using polyclonal antibodies raised against a mixture of these polypeptides, immunohistochemistry was performed on a variety of tumor tissues and corresponding normal tissue. The results are shown in FIG. 3, and discussed in the Examples. These polypeptides are useful for detecting a higher level of expression of clone SL-5 in tumor tissues.
Use of Polynucleotides to Construct Arrays for Diagnostics [0116]
The present polynucleotide sequences and gene products are useful for determining the occurrence of cancer, tumor progression, hyperproliferative growth, and/or accompanying biological or physical manifestations. Specifically, the polynucleotides and encoded polypeptides of the instant invention can be utilized to determine the occurrence of prostatic disorders, such as BPH or localized prostate cancer. [0117]
A number of prostatic disorders exist, including adenocarcinoma, BPH, histologic prostate cancer, prostatic intraepithelial neoplasia, clinical prostate cancer, incidental prostate cancer, and localized prostate cancer. BPH is a common prostatic disorder in men which becomes clinically manifest usually after age fifty. In BPH, hyperplastic growth of prostatic cells in the periurethral glandular tissue in the central zone of the prostate gland cause an enlarged prostate which can compress or elongate the urethra and produce symptoms of urethral obstruction that may progress to urinary retention or to a constellation of symptoms known as prostatism. A host of physical manifestations can accompany prostatic disorders including: impotency, reduced urinary flow, hesitancy in initiating voiding, postvoid dribbling, a sensation of incomplete bladder emptying, and development of bladder or high urinary tract infections. [0118]
To determine the occurrence of cancer, tumor progression, hyperproliferative growth, and/or accompanying biological or physical manifestations, the levels of polynucleotides and/or encoded polypeptides of the present invention in a sample are compared to the levels in a normal control of body tissues, cells, organs, or fluids. The normal control can include a pool of cells from a particular organ or tissue or tissues and/or cells from throughout the body. Either the immunoassays described above or the nucleic acid assays described below can be used for such measurements. [0119]
Any observed difference between the sample and normal control can indicate the occurrence of disease or disorder. Typically, if the levels of the polynucleotides and the encoded polypeptides of the present invention are higher than those found in the normal control, the results indicate the occurrence of cancer, tumor progression, hyperproliferative growth, and/or accompanying biological or physical manifestations. [0120]
In addition, the present polynucleotides can be useful to diagnose the severity as well as the occurrence of cancer, tumor progression, hyperproliferative growth, and/or accompanying biological or physical manifestations, including prostatic disorders. For example, the greater the difference observed in the sample versus the normal control of the present polynucleotides or encoded polypeptides, the greater the severity of the disorder, in particular, when higher levels as compared to a normal control are observed. [0121]
The present polynucleotides, as shown in SEQ ID NO:1-339, were expressed at higher levels in a prostate cancer cell line versus a normal prostate epithelial cell line. [0122]
Polynucleotide arrays provide a high throughput technique that can assay a large number of polynucleotide sequences in a sample. This technology can be used as a diagnostic and as a tool to test for differential expression to determine function of an encoded protein. [0123]
To create arrays, polynucleotide probes are spotted onto a substrate in a two-dimensional matrix or array. Samples of polynucleotides can be labeled and then hybridized to the probes. Double stranded polynucleotides, comprising the labeled sample polynucleotides bound to probe polynucleotides, can be detected once the unbound portion of the sample is washed away. [0124]
The probe polynucleotides can be spotted on substrates including glass, nitrocellulose, etc. The probes can be bound to the substrate by either covalent bonds or by non-specific interactions, such as hydrophobic interactions. The sample polynucleotides can be labeled using radioactive labels, fluorophors, etc. [0125]
Techniques for constructing arrays and methods of using these arrays are described in EP No. 0 799 897; PCT No. WO 97/29212; PCT No WO 97/27317; EP No. 0 785 280; PCT No. WO 97/02357; U.S. Pat. No. 5,593,839; U.S. Pat. No. 5,578,832; EP No. 0 728 520; U.S. Pat. No. 5,599,695; EP No. 0 721 016; U.S. Pat, No. 5,556,752; PCT No. WO 95/22058; and U.S. Pat. No. 5,631,734. [0126]
Further, arrays can be used to examine differential expression of genes and can be used to determine gene function. For example, arrays of the instant polynucleotide sequences can be used to determine if any of the EST sequences are differentially expressed between normal cells and cancer cells, for example. High expression of a particular message in a cancer cell, which is not observed in a corresponding normal cell, can indicate a cancer specific protein. [0127]
Differential Expression [0128]
The present invention also provides a method to identify abnormal or diseased tissue in a human. For polynucleotides corresponding to profiles of protein families as described above, the choice of tissue may be dictated by the putative biological function. The expression of a gene corresponding to a specific polynucleotide is compared between a first tissue that is suspected of being diseased and a second, normal tissue of the human. The normal tissue is any tissue of the human, especially those that express the polynucleotide-related gene including, but not limited to, brain, thymus, testis, heart, prostate, placenta, spleen, small intestine, skeletal muscle, pancreas, and the mucosal lining of the colon. [0129]
The polynucleotide-related genes in the two tissues are compared by any means known in the art. For example, the two genes are sequenced, and the sequence of the gene in the tissue suspected of being diseased is compared with the gene sequence in the normal tissue. The polynucleotide-related genes, or portions thereof, in the two tissues are amplified, for example using nucleotide primers based on the nucleotide sequence shown in the Sequence Listing, using the polymerase chain reaction. The amplified genes or portions of genes are hybridized to nucleotide probes selected from the same nucleotide sequence shown in the Sequence Listing. A difference in the nucleotide sequence of the polynucleotide-related gene in the tissue suspected of being diseased compared with the normal nucleotide sequence suggests a role of the polynucleotide-encoded proteins in the disease, and provides a lead for preparing a therapeutic agent. The nucleotide probes are labeled by a variety of methods, such as radiolabeling, biotinylation, or labeling with fluorescent or chemiluminescent tags, and detected by standard methods known in the art. [0130]
Alternatively, polynucleotide-related mRNA in the two tissues is compared. PolyA[0131] ⁺ RNA is isolated- from the two tissues as is known in the art. For example, one of skill in the art can readily determine differences in the size or amount of polynucleotide-related mRNA transcripts between the two tissues using Northern blots and nucleotide probes selected from the nucleotide sequence shown in the Sequence Listing. Increased or decreased expression of an polynucleotide-related mRNA in a tissue sample suspected of being diseased, compared with the expression of the same polynucleotide-related mRNA in a normal tissue, suggests that the expressed protein has a role in the disease, and also provides a lead for preparing a therapeutic agent.
Any method for analyzing proteins is used to compare two polynucleotide-encoded proteins from matched samples. The sizes of the proteins in the two tissues are compared, for example, using antibodies of the present invention to detect polynucleotide-encoded proteins in Western blots of protein extracts from the two tissues. Other changes, such as expression levels and subcellular localization, can also be detected immunologically, using antibodies to the corresponding protein. A higher or lower level of polynucleotide-encoded protein expression in a tissue suspected of being diseased, compared with the same polynucleotide-encoded protein expression level in a normal tissue, is indicative that the expressed protein has a role in the disease, and provides another lead for preparing a therapeutic agent. [0132]
Similarly, comparison of polynucleotide gene sequences or of polynucleotide gene expression products, e.g., mRNA and protein, between a human tissue that is suspected of being diseased and a normal tissue of a human, are used to follow disease progression or remission in the human Such comparisons of polynucleotide-related genes, mRNA, or protein are made as described above. [0133]
For example, increased or decreased expression of the polynucleotide-related gene in the tissue suspected of being neoplastic can indicate the presence of neoplastic cells in the tissue. The degree of increased expression of the polynucleotide gene in the neoplastic tissue relative to expression of the gene in normal tissue, or differences in the amount of increased expression of the polynucleotide gene in the neoplastic tissue over time, is used to assess the progression of the neoplasia in that tissue or to monitor the response of the neoplastic tissue to a therapeutic protocol over time. The expression pattern of any two cell types can be compared, such as low and high metastatic tumor cell lines, or cells from tissue which have and have not been exposed to a therapeutic agent. [0134]
Screening for Peptide Analogs and Antagonists [0135]
Polypeptides encoded by the instant polynucleotides and corresponding full length genes can be used to screen peptide libraries to identify binding partners, such as receptors, from among the encoded polypeptides. [0136]
Such binding partners can be useful in treating cancer, tumor progression, hyperproliferative cell growth, and/or accompanying biological or physical manifestations. For example, peptides or other compounds that are capable of binding or interacting with membrane-bound polypeptides encoded by one or more of SEQ ID NO:1-339, can be useful as a therapeutic. Also, peptides or other compounds capable of altering the conformation of any of the encoded polypeptides by one or more of SEQ ID NO:1-339 can inhibit biological activity and be useful as a therapeutic. [0137]
A library of peptides may be synthesized following the methods disclosed in U.S. Pat. No. 5,010,175, and in PCT WO91/17823. [0138]
Peptide agonists or antagonists are screened using any available method, such as signal transduction, antibody binding, receptor binding, mitogenic assays, chemotaxis assays, etc The methods described herein are presently preferred. The assay conditions ideally should resemble the conditions under which the native activity is exhibited in vivo, that is, under physiologic pH, temperature, and ionic strength. Suitable agonists or antagonists will exhibit strong inhibition or enhancement of the native activity at concentrations that do not cause toxic side effects in the subject. Agonists or antagonists that compete for binding to the native polypeptide may require concentrations equal to or greater than the native concentration, while inhibitors capable of binding irreversibly to the polypeptide may be added in concentrations on the order of the native concentration. [0139]
The end results of such screening and experimentation will be at least one novel polypeptide binding partner, such as a receptor, encoded by a cDNA polynucleotide or gene of the invention, and at least one peptide agonist or antagonist of the novel binding partner. Such agonists and antagonists can be used to modulate, enhance, or inhibit receptor function in cells to which the receptor is native, or in cells that possess the receptor as a result of genetic engineering. Further, if the novel receptor shares biologically important characteristics with a known receptor, information about agonist/antagonist binding may help in developing improved agonists/antagonists of the known receptor. [0140]
Therapeutics, whether polynucleotide or polypeptide or small molecule, can be tested, for example, in the mouse tumor assay described in Pei et al., [0141] Mol. Endo. 11: 433-441 (1997).
Other models for testing polynucleotides, polypeptides, antibodies, or small molecules useful for treatment include: animal models and cell lines disclosed in Bosland, [0142] Encyclopedia of Cancer, Volume II, pages 1283 to 1296 (1997) by Academic Press. Other useful cell lines are described in Brothman, Encyclopedia of Cancer, Volume II, pages 1303 to 1313 (1997) by Academic Press
Pharmaceutical Compositions and Therapeutic Uses [0143]
Pharmaceutical compositions can comprise polypeptides, antibodies, or polynucleotides of the claimed invention. The pharmaceutical compositions will comprise a therapeutically effective amount of either polypeptides, antibodies, or polynucleotides of the claimed invention. [0144]
The term “therapeutically effective amount” as used herein refers to an amount of a therapeutic agent to treat, ameliorate, or prevent a desired disease or condition, or to exhibit a detectable therapeutic or preventative effect. The effect can be detected by, for example, chemical markers or antigen levels. Therapeutic effects also include reduction in physical symptoms, such as decreased body temperature. The precise effective amount for a subject will depend upon the subject's size and health, the nature and extent of the condition, and the therapeutics or combination of therapeutics selected for administration. Thus, it is not useful to specify an exact effective amount in advance. However, the effective amount for a given situation can be determined by routine experimentation and is within the judgment of the clinician. Specifically, the compositions of the present invention can be used to treat, ameliorate, modulate, or prevent cancer, tumor progression, hyperproliferative cell growth and/or accompanying biological or physical manifestations, including prostatic disorders. [0145]
For purposes of the present invention, an effective dose will be from about 0.01 mg/kg to 50 mg/kg or 0.05 mg/kg to about 10 mg/kg of the polynucleotide, polypeptide or antibody compositions in the individual to which it is administered. [0146]
A pharmaceutical composition can also contain a pharmaceutically acceptable carrier. The term “pharmaceutically acceptable carrier” refers to a carrier for administration of a therapeutic agent, such as antibodies or a polypeptide, genes, and other therapeutic agents. The term refers to any pharmaceutical carrier that does not itself induce the production of antibodies harmful to the individual receiving the composition, and which may be administered without undue toxicity. Suitable carriers may be large, slowly metabolized macromolecules such as proteins, polysaccharides, polylactic acids, polyglycolic acids, polymeric amino acids, amino acid copolymers, and inactive virus particles. Such carriers are well known to those of ordinary skill in the art. [0147]
Pharmaceutically acceptable salts can be used therein, for example, mineral acid salts such as hydrochlorides, hydrobromides, phosphates, sulfates, and the like; and the salts of organic acids such as acetates, propionates, malonates, benzoates, and the like. A thorough discussion of pharmaceutically acceptable excipients is available in [0148] Remington 's Pharmaceutical Sciences (Mack Pub. Co., N.J. 1991).
Pharmaceutically acceptable carriers in therapeutic compositions may contain liquids such as water, saline, glycerol and ethanol. Additionally, auxiliary substances, such as wetting or emulsifying agents, pH buffering substances, and the like, may be present in such vehicles. Typically, the therapeutic compositions are prepared as injectables, either as liquid solutions or suspensions; solid forms suitable for solution in, or suspension in, liquid vehicles prior to injection may also be prepared. Liposomes are included within the definition of a pharmaceutically acceptable carrier. [0149]
Delivery Methods [0150]
Once formulated, the polynucleotide compositions of the invention can be (1) administered directly to the subject; (2) delivered ex vivo, to cells derived from the subject; or (3) delivered in vitro for expression of recombinant proteins. [0151]
Direct delivery of the compositions will generally be accomplished by injection, either subcutaneously, intraperitoneally, intravenously or intramuscularly, or delivered to the interstitial space of a tissue. The compositions can also be administered into a tumor or lesion. Other modes of administration include oral and pulmonary administration, suppositories, and transdermal applications, needles, and gene guns or hyposprays. Dosage treatment may be a single dose schedule or a multiple dose schedule. [0152]
Methods for the ex vivo delivery and reimplantation of transformed cells into a subject are known in the art and described in e.g., International Publication No. WO 93/14778. Examples of cells useful in ex vivo applications include, for example, stem cells, particularly hematopoetic, lymph cells, macrophages, dendritic cells, or tumor cells. [0153]
Generally, delivery of nucleic acids for both ex vivo and in vitro applications can be accomplished by, for example, dextran-mediated transfection, calcium phosphate precipitation, polybrene mediated transfection, protoplast fusion, electroporation, encapsulation of the polynucleotide(s) in liposomes, and direct microinjection of the DNA into nuclei, all well known in the art. [0154]
If a polynucleotide-related gene correlates with a proliferative disorder, such as neoplasia, dysplasia, and hyperplasia, the disorder may be amenable to treatment by administration of a therapeutic agent based on the polynucleotide or corresponding polypeptide. [0155]
Preparation of antisense polypeptides is discussed above. Neoplasias that are treated with the antisense composition include, but are not limited to, cervical cancers, melanomas, colorectal adenocarcinomas, Wilms' tumor, retinoblastoma, sarcomas, myosarcomas, lung carcinomas, leukemias, such as chronic myelogenous leukemia, promyelocytic leukemia, monocytic leukemia, and myeloid leukemia, and lymphomas, such as histiocytic lymphoma. Proliferative disorders that are treated with the therapeutic composition include disorders such as anhydric hereditary ectodermal dysplasia, congenital alveolar dysplasia, epithelial dysplasia of the cervix, fibrous dysplasia of bone, and mammary dysplasia. Hyperplasias, for example, endometrial, adrenal, breast, prostate, or thyroid hyperplasias or pseudoepitheliomatous hyperpiasia of the skin, are treated with antisense therapeutic compositions. Even in disorders in which mutations in the corresponding gene are not implicated, downregulation or inhibition of gene expression can have therapeutic application. For example, decreasing gene expression can help to suppress tumors in which enhanced expression of the gene is implicated. [0156]
Both the dose of the antisense composition and the means of administration are determined based on the specific qualities of the therapeutic composition, the condition, age, and weight of the patient, the progression of the disease, and other relevant factors. Administration of the therapeutic antisense agents of the invention includes local or systemic administration, including injection, oral administration, particle gun or catheterized administration, and topical administration. Preferably, the therapeutic antisense composition contains an expression construct comprising a promoter and a polynucleotide segment of at least 12, 22, 25, 30, or 35 contiguous nucleotides of the antisense strand. Within the expression construct, the polynucleotide segment is located downstream from the promoter, and transcription of the polynucleotide segment initiates at the promoter. [0157]
Various methods are used to administer the therapeutic composition directly to a specific site in the body. For example, a small metastatic lesion is located and the therapeutic composition injected several times in several different locations within the body of tumor. Alternatively, arteries which serve a tumor are identified, and the therapeutic composition injected into such an artery, in order to deliver the composition directly into the tumor. A tumor that has a necrotic center is aspirated and the composition injected directly into the now empty center of the tumor. The antisense composition is directly administered to the surface of the tumor, for example, by topical application of the composition. X-ray imaging is used to assist in certain of the above delivery methods. [0158]
Receptor-mediated targeted delivery of therapeutic compositions containing an antisense polynucleotide, subgenomic polynucleotides, or antibodies to specific tissues is also used. Receptor-mediated DNA delivery techniques are described in, for example, Findeis et al., [0159] Trends in Biotechnol. (1993) 11:202-205; Chiou et al., (1994) Gene Therapeutics: Methods And Applications Of Direct Gene Transfer (J. A. Wolff, ed.); Wu & Wu, J. Biol. Chem. (1988) 263-621-24; Wu et al., J. Biol. Chem. (1994) 269:542-46; Zenke et al., Proc. Natl. Acad. Sci. (USA) (1990) 87:3655-59; Wu et al., J. Biol. Chem. (1991) 266:339-42. Preferably, receptor-mediated targeted delivery of therapeutic compositions containing antibodies of the invention is used to deliver the antibodies to specific tissue.
Therapeutic compositions containing antisense subgenomic polynucleotides are administered in a range of about 100 ng to about 200 mg of polynucleotides for local administration in a gene therapy protocol. Concentration ranges of about 500 ng to about 50 mg, about 1 μg to about 2 mg, about 5 μg to about 500 μg, and about 20 μg to about 100 μg of polynucleotides can also be used during a gene therapy protocol. Factors such as method of action and efficacy of transformation and expression are considerations which will affect the dosage required for ultimate efficacy of the antisense subgenomic polynucleotides. Where greater expression is desired over a larger area of tissue, larger amounts of EST antisense subgenomic polynucleotides or the same amounts readministered in a successive protocol of administrations, or several administrations to different adjacent or close tissue portions of, for example, a tumor site, may be required to effect a positive therapeutic outcome. In all cases, routine experimentation in clinical trials will determine specific ranges for optimal therapeutic effect. A more complete description of gene therapy vectors, especially retroviral vectors, is contained in U.S. Ser. No. 08/869,309, which is expressly incorporated herein, and in section G below. [0160]
For genes encoding polypeptides or proteins with anti-inflammatory activity, suitable use, doses, and administration are described in U.S. Pat. No. 5,654,173, incorporated herein by reference. Therapeutic agents also include antibodies to proteins and polypeptides, as described in U.S. Pat. No. 5,654,173. [0161]
Gene Therapy [0162]
The therapeutic polynucleotides and polypeptides of the present invention may be utilized in gene delivery vehicles. The gene delivery vehicle may be of viral or non-viral origin (see generally, Jolly, [0163] Cancer Gene Therapy (1994) 1:51-64; Kimura, Human Gene Therpay (1994) 5:845-852; Connelly, Human Gene Therapy (1995) 1:185-193; and Kaplitt, Nature Genetics (1994) 6:148-153). Gene therapy vehicles for delivery of constructs including a coding sequence of a therapeutic of the invention can be administered either locally or systemically These constructs can utilize viral or non-viral vector approaches. Expression of such coding sequences can be induced using endogenous mammalian or heterologous promoters. Expression of the coding sequence can be either constitutive or regulated.
The present invention can employ recombinant retroviruses which are constructed to carry or express a selected nucleic acid molecule of interest. Retrovirus vectors that can be employed include those described in EP 0 415 731; WO 90/07936; WO 94/03,622; WO 93/25698; WO 93/25234; U.S. Pat. No. 5,219,740; WO 93/11230; WO 93/10218; Vile and Hart, [0164] Cancer Res. (1993) 53:3860-3864; Vile and Hart, Cancer Res. (1993) 53:962-967; Ram et al., Cancer Res. (1993) 53:83-88; Takamiya et al., J. Neurosci. Res. (1992) 33:493-503; Baba et al., J. Neurosurg. (1993) 79:729-735; U.S. Pat. No. 4,777,127, GB Patent No. 2,200,651; and EP 0 345 242. Preferred recombinant retroviruses include those described in WO 91/02805.
Packaging cell lines suitable for use with the above-described retroviral vector constructs may be readily prepared (see PCT publications WO 95/30763 and WO 92/05266), and used to create producer cell lines (also termed vector cell lines) for the production of recombinant vector particles. Within particularly preferred embodiments of the invention, packaging cell lines are made from human (such as HT1080 cells) or mink parent cell lines, thereby allowing production of recombinant retroviruses that can survive inactivation in human serum. [0165]
The present invention also employs alphavirus-based vectors that can function as gene delivery vehicles. Such vectors can be constructed from a wide variety of alphaviruses, including, for example, Sindbis virus vectors, Semliki forest virus (ATCC VR-67; ATCC VR-1247), Ross River virus (ATCC VR-373; ATCC VR-1246) and Venezuelan equine encephalitis virus (ATCC VR-923; ATCC VR-1250; ATCC VR 1249; ATCC VR-532). Representative examples of such vector systems include those described in U.S. Pat. Nos. 5,091,309; 5,217,879; and 5,185,440; and PCT Publication Nos. WO 92/10578; WO 94/21792; WO 95/27069; WO 95/27044; and WO 95/07994. [0166]
Gene delivery vehicles of the present invention can also employ parvovirus such as adeno-associated virus (AAV) vectors. Representative examples include the AAV vectors disclosed by Srivastava in WO 93/09239, Samulski et al., [0167] J. Vir. (1989) 63:3822-3828; Mendelson et al., Virol. (1988) 166:154-165; and Flotte et al., PNAS (1993) 90:10613-10617.
Representative examples of adenoviral vectors include those described by Berkner, [0168] Biotechniques (1988) 6:616-627; Rosenfeld et al, Science (1991) 252:431-434; WO 93/19191; Kolls et al., PNAS (1994) 91:215-219; Kass-Eisler et al., PNAS (1993) 90:11498-11502; Guzman et al., Circulation (1993) 88:2838-2848; Guzman et al., Cir. Res. (1993) 73:1202-1207; Zabner et al., Cell (1993) 75:207-216; Li et al., Hum. Gene Ther. (1993) 4:403-409; Cailaud et al., Eur. J. Neurosci. (1993) 5:1287-1291; Vincent et al., Nat. Genet. (1993) 5:130-134; Jaffe et al., Nat. Genet. (1992) 1:372-378; and Levrero et al., Gene (1991) 101:195-202. Exemplary adenoviral gene therapy vectors employable in this invention also include those described in WO 94/12649, WO 93/03769; WO 93/19191; WO 94/28938; WO 95/11984 and WO 95/00655. Administration of DNA linked to killed adenovirus as described in Curiel, Hum. Gene Ther. (1992)3:147-154 may be employed.
Other gene delivery vehicles and methods may be employed, including polycationic condensed DNA linked or unlinked to killed adenovirus alone, for example Curiel, [0169] Hum. Gene Ther. (1992) 3:147-154; ligand linked DNA, for example see Wu, J. Biol. Chem. (1989) 264:16985-16987; eukaryotic cell delivery vehicles cells, for example see U.S. Ser. No. 08/240,030, filed May 9, 1994, and U.S. Ser. No. 08/404,796; deposition of photopolymerized hydrogel materials; hand-held gene transfer particle gun, as described in U.S. Pat. No. 5,149,655; ionizing radiation as described in U.S. Pat. No. 5,206,152 and in WO92/11033; nucleic charge neutralization or fusion with cell membranes. Additional approaches are described in Philip, Mol. Cell Biol. (1994) 14:2411-2418, and in Woffendin, Proc. Natl. Acad. Sci. (1994) 91:1581-1585.
Naked DNA may also be employed. Exemplary naked DNA introduction methods are described in WO 90/11092 and U.S. Pat. No. 5,580,859. [0170]
Further non-viral delivery suitable for use includes mechanical delivery systems such as the approach described in Woffendin et al., [0171] Proc. Natl. Acad. Sci. USA (1994) 91(24):11581-11585.
Computer-Related Embodiments [0172]
In general, a library of polynucleotides is a collection of sequence information, which information is provided in either biochemical form (e.g., as a collection of polynucleotide molecules), or in electronic form (e.g., as a collection of polynucleotide sequences stored in a computer-readable form, as in a computer system and/or as part of a computer program). The sequence information of the polynucleotides can be used in a variety of ways, e.g., as a resource for gene discovery, as a representation of sequences expressed in a selected cell type (e.g., cell type markers), and/or as markers of a given disease or disease state. In general, a disease marker is a representation of a gene product that is present in all cells affected by disease either at an increased or decreased level relative to a normal cell (e.g., a cell of the same or similar type that is not substantially affected by disease). [0173]
The nucleotide sequence information of the library can be embodied in any suitable form, e.g., electronic or biochemical forms. For example, a library of sequence information embodied in electronic form comprises an accessible computer data file (or, in biochemical form, a collection of nucleic acid molecules) that contains the representative nucleotide sequences of genes that are differentially expressed (e.g., overexpressed or underexpressed) as between, for example, a cancerous cell and a normal cell. Biochemical embodiments of the library include a collection of nucleic acids that have the sequences of the genes in the library, where the nucleic acids can correspond to the entire gene in the library or to a fragment thereof, as described in greater detail below. [0174]
The polynucleotide libraries of the subject invention generally comprise sequence information of a plurality of polynucleotide sequences, where at least one of the polynucleotides has a sequence of any of SEQ ID NOs:1-339. By plurality is meant at least 2, usually at least 3 and can include up to all of SEQ ID NOs:1-339. The length and number of polynucleotides in the library will vary with the nature of the library, e.g., if the library is an oligonucleotide array, a cDNA array, a computer database of the sequence information, etc. [0175]
Where the library is an electronic library, the nucleic acid sequence information can be present in a variety of media. “Media” refers to a manufacture, other than an isolated nucleic acid molecule, that contains the sequence information of the present invention. Such a manufacture provides the genome sequence or a subset thereof in a form that can be examined by means not directly applicable to the sequence as it exists in a nucleic acid. For example, the nucleotide sequence of the present invention, e.g., the nucleic acid sequences of any of the polynucleotides of SEQ ID NOs:1-339, can be recorded on computer readable media, e.g., any medium that can be read and accessed directly by a computer. Such media include, but are not limited to: magnetic storage media, such as a floppy disc, a hard disc storage medium, and a magnetic tape; optical storage media such as CD-ROM; electrical storage media such as RAM and ROM; and hybrids of these categories such as magnetic/optical storage media. One of skill in the art can readily appreciate how any of the presently known computer readable mediums can be used to create a manufacture comprising a recording of the present sequence information. “Recorded” refers to a process for storing information on computer readable medium, using any such methods as known in the art. Any convenient data storage structure can be chosen, based on the means used to access the stored information. A variety of data processor programs and formats can be used for storage, e.g., word processing text file, database format, etc. In addition to the sequence information, electronic versions of the libraries of the invention can be provided in conjunction or connection with other computer-readable information and/or other types of computer-readable files (e.g., searchable files, executable files, etc, including, but not limited to, for example, search program software, etc.). [0176]
By providing the nucleotide sequence in computer readable form, the information can be accessed for a variety of purposes. Computer software to access sequence information is publicly available. For example, the BLAST (Altschul et al., supra.) and BLAZE (Brutlag et al. [0177] Comp. Chem. (1993) 17:203) search algorithms on a Sybase system can be used to identify open reading frames (ORFs) within the genome that contain homology to ORFs from other organisms.
As used herein, “a computer-based system” refers to the hardware means, software means, and data storage means used to analyze the nucleotide sequence information of the present invention. The minimum hardware of the computer-based systems of the present invention comprises a central processing unit (CPU), input means, output means, and data storage means. A skilled artisan can readily appreciate that any one of the currently available computer-based system are suitable for use in the present invention. The data storage means can comprise any manufacture comprising a recording of the present sequence information as described above, or a memory access means that can access such a manufacture. [0178]
“Search means” refers to one or more programs implemented on the computer-based system, to compare a target sequence or target structural motif, or expression levels of a polynucleotide in a sample, with the stored sequence information. Search means can be used to identify fragments or regions of the genome that match a particular target sequence or target motif A variety of known algorithms are publicly known and commercially available, e.g., MacPattern (EMBL), BLASTN and BLASTX (NCBI). A “target sequence” can be any polynucleotide or amino acid sequence of six or more contiguous nucleotides or two or more amino acids, preferably from about 10 to 100 amino acids or from about 30 to 300 nt A variety of comparing means can be used to accomplish comparison of sequence information from a sample (e.g., to analyze target sequences, target motifs, or relative expression levels) with the data storage means. A skilled artisan can readily recognize that any one of the publicly available homology search programs can be used as the search means for the computer based systems of the present invention to accomplish comparison of target sequences and motifs. Computer programs to analyze expression levels in a sample and in controls are also known in the art. [0179]
A “target structural motif,” or “target motif,” refers to any rationally selected sequence or combination of sequences in which the sequence(s) are chosen based on a three-dimensional configuration that is formed upon the folding of the target motif, or on consensus sequences of regulatory or active sites. There are a variety of target motifs known in the art. Protein target motifs include, but arc not limited to, enzyme active sites and signal sequences. Nucleic acid target motifs include, but are not limited to, hairpin structures, promoter sequences and other expression elements such as binding sites for transcription factors. [0180]
A variety of structural formats for the input and output means can be used to input and output the information in the computer-based systems of the present invention. One format for an output means ranks the relative expression levels of different polynucleotides. Such presentation provides a skilled artisan with a ranking of relative expression levels to determine a gene expression profile. [0181]
As discussed above, the “library” of the invention also encompasses biochemical libraries of the polynucleotides of SEQ ID NOs:1-339, e.g., collections of nucleic acids representing the provided polynucleotides. The biochemical libraries can take a variety of forms, e.g., a solution of cDNAs, a pattern of probe nucleic acids stably associated with a surface of a solid support (i.e., an array) and the like. Of particular interest are nucleic acid arrays in which one or more of SEQ ID NOs:1-339 is represented on the array. By array is meant a an article of manufacture that has at least a substrate with at least two distinct nucleic acid targets on one of its surfaces, where the number of distinct nucleic acids can be considerably higher, typically being at least 10 nt, usually at least 20 nt and often at least 25 nt. A variety of different array formats have been developed and are known to those of skill in the art. The arrays of the subject invention find use in a variety of applications, including gene expression analysis, drug screening, mutation analysis and the like, as disclosed in the above-listed exemplary patent documents. [0182]
In addition to the above nucleic acid libraries, analogous libraries of polypeptides are also provided, where the where the polypeptides of the library will represent at least a portion of the polypeptides encoded by SEQ ID NOs:1-339. [0183]
The present invention will now be illustrated by reference to the following examples which set forth particularly advantageous embodiments. However, it should be noted that these embodiments are illustrative and are not to be construed as restricting the invention in any way. [0184]

EXAMPLES

Example 1

Isolation of the Polynucleotides

cDNA libraries were prepared from PrEC, normal human prostate epithelial cells, and LNCaP, a cell line derived from human lymph node metastasized prostate cancer. PrEC cells are available from Clonetics, San Diego, Calif., U.S.A. LNCaP cells are available from the ATCC, Manassas, Va., U.S.A. [0185]
Using a PCR technique and reagents available from Clontech, Palo Alto, Calif., USA (CLONTECH PCR-Select™), mRNA up-regulated in LNCaP was captured and amplified. The captured polynucleotide inserts were inserted in the pCR2.1 vector, available from Invitrogen, Carlsbad, Calif., U.S.A. The vectors with the inserts were transformed into [0186] E. coli cells.

Example 2

Confirmation of Differential Display

Ten clones were chosen at random, and up-regulation of the sequences of these clone inserts in LNCaP versus PrEC cells was confirmed by Northern blot. Dot blots were performed on 168 clones and up-regulation was confirmed. [0187]
Further, sequencing of the clones showed that prostate specific antigen (PSA) and prostate specific membrane antigen (PSMA) sequences were isolated by the process described in Example 1. A good correlation between increased serum PSA levels and prostate tumors has been observed. PSMA, a cell surface antigen, is another observed marker for prostate cancer. See Bosland, Encyclopedia of Cancer, Volume II, pages 1283-1296 (1997), Academic Press. Thus, the data confirm that up-regulated mRNA characteristic of gene expression in prostate cancer was cloned by the method of Example 1. [0188]

Example 3

Polynucleotide Sequences

The sequence results are shown in SEQ ID NO:1-339. For the sequencing experiments, each clone was named SL-1 to SL-209. Inserts from some of the clones were sequenced more than once. Each sequence was designated a unique combination of two names. This unique combination is shown in Table 1 in [0189] columns 2 and 3, denoted as “Sequence Name” and “Other Seq Name.”
Table 1 indicates all the sequences that correspond to each clone. Thus, all the sequences corresponding to clone SL-3, for example, are grouped together in Table 1. [0190]
Clones also were assigned cluster numbers. See [0191] column 4 of Table 1. Clones with the same cluster number generally comprise sequence derived from the same mRNA transcripts.
The last column of Table 1 indicates the nearest neighbor as determined by an alignment to sequences in a publicly available database. [0192]
A consensus for the sequence of each clone can be constructed by aligning the corresponding sequences or reverse complements thereof. Table 1 lists the names of all the sequences that correspond to each clone, and Table 2 shows the specific sequence that corresponds to each unique combination of Sequence Name and/or “Other Seq. Name.”[0193]
The entire insert of some clones may not be represented by the sequences presented in Table 2. For example, the 5′ and 3′ ends of a clone insert may have been sequenced, but the sequences do not overlap Additional sequence corresponding to the clone insert can be isolated and determined by constructing probes or primers from the sequences presented in Table 2 and a library of mRNA or cDNA from a prostate cell or prostate cancer cell line using the methods described above. [0194]

Example 4

Results of Public Database Search

Both the nucleotide sequence and translations of masked sequences shown in the Sequence Listing were aligned with individual sequences that were publicly available. Similarity with individual sequences is used to determine the activity of the polypeptides encoded by genes corresponding to the sequences referred to in Table 2. [0195]
The sequences in SEQ ID NO:1-333 first were masked to remove the pCR2.1 vector sequences. Masking was performed by aligning the pCR2.1 sequences with each of SEQ ID NO:1-333 using the BLASTN program. Any sequence that produced an alignment with a score of less that 0.1 was masked. [0196]
A BLASTN vs. Genbank search was performed using the masked sequences with search parameters of greater than 99% overlap, 99% identity, and a p value of less than 1×10[0197] ⁻⁴⁰and this resulted in discard of sequences. Sequences from this search also were discarded if the inclusive parameters were met, but the sequence was ribosomal or vector-derived.
The resulting sequences from the previous search were classified into three groups (1, 2 and 3 below) and searched in a BLASTX vs. NRP (non-redundant proteins) database search: (1) unknown (no hits in the Genbank search), (2) weak similarity (greater than 45% identity and p value of less than 1×10[0198] ⁻⁵), and (3) high similarity (greater than 60% overlap, greater than 80% identity, and p value less than 1×10⁻⁵). This search resulted in discard of sequences as having greater than 99% overlap, greater than 99% identity, and p value of less than 1×10⁻⁴⁰.
The remaining sequences were classified as unknown (no hits), weak similarity, and high similarity (parameters as above). Two searches were performed on this set of sequences. First, a BLAST vs. EST database search resulted in discard of sequences with greater than 99% overlap, greater than 99% similarity and a p value of less than 1×10[0199] ⁻⁴⁰; sequences with a p value of less than 1×10⁻⁶⁵when compared to a database sequence of human origin were also excluded. Second, a BLASTN vs. Patent GeneSeq database resulted in discard of sequences with greater than 99% identity; p value less than 1×10⁻⁴⁰; greater than 99% overlap.
The masked sequences were translated in all six reading frames to determine the best alignment with the individual sequences. These amino acid sequences and nucleotide sequences are referred, generally, as query sequences, which are aligned with the individual sequences. [0200]
Query and individual sequences were aligned using the BLAST programs, available over the world wide web. [0201]
Table 2 shows the results of the alignments. Table 2 refers to each sequence by its Sequence Name and/or “Other Seq. Name” and includes the accession numbers and descriptions of nearest neighbors from the Genbank and Non-Redundant Protein searches. [0202]
The activity of the polypeptide encoded by the sequences referred to in Table 2 is expected to be the same or similar to the nearest neighbor reported in Table 2. The accession number of the nearest neighbor is reported, providing a reference to the activities exhibited by the nearest neighbor. The search program and database used for the alignment also are indicated as well as a calculation of the p value. [0203]
Full length sequences or fragments of the polynucleotide sequences of the nearest neighbors can be used as probes and primers to identify and isolate the full length sequence corresponding to sequence referred to in Table 2. Although full length sequences can be obtained from the cell lines described above, the nearest neighbors can indicate a tissue or cell type to be used to construct a library for the full-length sequences of those referred to in Table 2. [0204]
The sequences referred to in Table 2 and the translations thereof may be human homologs of known genes of other species or novel allelic variants of known human genes. In such cases, these new human sequences may be suitable as diagnostics, prognostics, or therapeutics. As diagnostics, the human sequences exhibit greater specificity in detecting and differentiating human cell lines and types than homologs of other species. The human polypeptides are less likely to be immunogenic when administered to humans than homologs from other species. Further, on administration to humans, the encoded polypeptides can show greater specificity or can be better regulated by other human proteins than are homologs from other species. [0205]
In the preferred embodiments of the invention, the sequences shown in SEQ ID NO 1-339 consisting of the unmasked regions should be considered as the source of probes and primers, as these sequences are most representative of the distinguishing portions of these polynucleotides. [0206]
Generally, the masking itself does not influence the search results as shown in Table 2, except to eliminate multiple “hits” based on similarity to repetitive regions common to more than one polypeptide. [0207]

Example 5

Analysis of Clones SL-5, SL-9, SL-68, AND SL-173

Clone SL-5 (SEQ ID NO:14 and 334) [0208]
By Northern Blot, a 4.1 kb band was observed in expressed in normal prostate, testis, and lymphoblasic leukemia. It was also expressed in the cell lines LNCaP, and MDA PCa 2A and 2B (metastatic prostate cells into bone, androgen sensitive). Additional sequence corresponding to SEQ ID NO:14 is disclosed in SEQ ID NO:334. [0209]
Expression of SL-5 was investigated in normal and tumor tissues using immunohistochemistry. Antibody was prepared using two sequences from clone SL-5: H[0210] ₂N-CGPRLPSFPCPTHEPSTGQLSK-CONH₂and H₂N-CKDSQGLSDFKRNSRTTR-RSYKCCONH₂. Using polyclonal antibodies raised against a mixture of these polypeptides, immunohistochemistry (IHC) was performed on a variety of tumor tissues and corresponding normal tissue. The methods used were those described for the Manual IHC Protocol using BioGenex Reagents and Zymed AEC Solution, as known in the art. As shown in FIG. 3, SL-5 was detected in the following tumor tissue: adrenal, ovary, breast, colon, prostate, uterus, cervix, kidney, pancreas, liver, stomach, lymphoma, seminonia, thyroid, melanoma, basal cell carcinoma, and other tumor tissues. Where comparative normal tissue was available, expression in the corresponding normal tissue was lower than in the tumor tissue. Thus, SL-5 is a useful marker for cancer tissue including prostate.
Clone SL-9 (SEQ ID NO:18) [0211]
By Northern Blot, sequences from SL-9 were specifically expressed in normal spleen and normal peripheral blood leukocyte. Expression of the SL-9 sequences was observed also in promyelocytic leukemia HL-60, chronic mylogenous leukemia K-562, lymphoblastic leukemia MOLT-4, Burkitt's lymphoma, and Raji cancer cell lines by Northern Blot. [0212]
Clone SL-173 (SEQ ID NO:153 and 154) [0213]
By Northern Blot, SL173 was found in every cancer cell line tested. Sequence from SL-173 has similarity to and may be a human homologue of the rat tumor transforming gene, which was found in the pituitary and described in Pei et al., [0214] Mol. Endo. 11: 433-441 (1997) and Pei, J. Biol. Chem. 273(9): 5219-5225 (1998). When the rat tumor transforming gene was injected in NIH3T3cells, the cells became transformed and were able to form a tumor when injected into mice. (Pei et al., Mol. Endo. supra).
Clone SL-68 (SEQ ID NO:218 and 219) [0215]
Two transcripts, 2.6 kb and 4.3 kb, were observed in normal spleen, thymus and peripheral blood leukocytes, as well as in promyelocytic leukemia, chronic myelogenous leukemia and lymphoblastic leukemia. The 4.3 kb transcript was seen in normal testis, colon, Hela cell S3, colorectal adenocarcinoma and melanoma. The 2.6 kb band was found in the following prostate cell lines: PC-3 (metastatic to bone, androgen insensitive); DU-145 (metastatic to brain, androgen insensitive); FFpz (primary cells derived from normal prostate epithelium); Ffca (primary cells derived from [0216] Gleason Grade 3 prostate cancer epithelium); and WO-CA (primary cells derived from Gleason Grade 4 prostate cancer epithelium). However, higher expression was observed in LNCaP, MDA PCa 2A, HPV-7 and HPV-10. A 9.5 kb transcript was also observed in MDA PCa 2A and 2B. Additional sequence corresponding to this clone is disclosed in SEQ ID NO:335.
Clone SL69 (SEQ ID NO:220 and 221) [0217]
A weak 2.6 kb band was observed in normal testis as well as in chronic myelogenous leukemia and lymphoblastic leukemia. Additional sequence corresponding to this clone is disclosed in SEQ ID NO:336. [0218]
Clone SL86 (SEQ ID NO:242 and 243) [0219]
The sequence was expressed in normal prostate (2.7 kb and 1.1 kb) and testis (1.1 kb). Low expression was observed in a cancer cell line blot using the cell lines described above. 1.1 kb and 2.7 kb transcripts were observed in the cell lines LNCaP, and MDA PCa 2a and 2b (metastatic prostate cells into bone, androgen sensitive), and weak 1.1 kb transcript was seen in HPV-7 (immortalized normal prostate cells) and HPV-10 (immortalized prostate cancer cells). Additional sequence corresponding to this clone is disclosed in SEQ ID NO:337. [0220]
Clone SL195 (SEQ ID NO:288 and 289) [0221]
The sequence was expressed in normal prostate as a 1.9 kb transcript, and the same transcript also observed in all cell lines in the cancer cell line blot described above. It was more heavily expressed in HeLa cell S3 and chronic myelogenous leukemia, and was expressed in all prostate cell lines. Additional sequence corresponding to this clone is disclosed in SEQ ID NO:338. [0222]
Clone SL97 (SEQ ID NO:292 and 293) [0223]
Two transcripts, 2.4 kb and 4 kb, were observed in normal prostate and testis. Two very weak 2.4 kb signals were observed in Hela cell S3 and chronic myelogenous leukemia. The 2.4 kb transcript was expressed in all prostate cell lines. A 4 kb transcript was found in LNCaP, MDA PCa 2A and 2B. Additional sequence corresponding to this clone is disclosed in SEQ ID NO:339. [0224]
Those skilled in the art will recognize, or be able to ascertain, using not more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. Such specific embodiments and equivalents are intended to be encompassed by the following claims. [0225]
All patents, published patent applications and publications cited herein are incorporated by reference as if set forth fully herein. [0226]
1 341 1 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 1 accgcctcgn atccctagta acggccgcca gtgtgctgga attcgccctt tcatgcctat 60 aatcccagca cttggggagg ccgaggatct cctctctggt ggatcacttg agggcaggag 120 ttaagagacc atcctggcca acatgatgaa accctgtctc tactaaaaat acaaaaagta 180 gctgggcgtg gtggcatact cttacaatcc cagctacttg ggaggctgag gcaggagaat 240 cacttgaacc taggaagcag aggttgcagt gggccaagat cacaccacta tactctagcc 300 tgggcgacag aggtggggaa aaaagtagga cccctgtcct atattcaggt ttttctcaca 360 tatatgaacc catctaaatt ctacgttgtt aaaggtagct taggttaatt agtctatact 420 tatttaagac caatatgggg tgagatggat ttttttttta aaaatcctac agtaaggctt 480 tctactttcc ttctaatgag gaaaaaggtg acaaaaattc aagtgtcaat gtccccttcc 540 tgggaagagg tttagaaaaa caacagctca ccttctgaac tctaccagtt ccttttgaag 600 ttaacgaagc attaaaatca gatgtaaaaa aagaaaaaaa aaggcaggga aatatttaca 660 aaactggaca ttctttacag atatacaatc ttgctaatac tgggagaacc nttccaagga 720 tgtataaaga ggagacgnca ccttagtaat gccagggata gagaaaaccc nggatataat 780 atggggtttt taatgccgga acatggngga aactaggang agccgagatg ganctggtcc 840 ctgaagtgaa ctggttnagn tattctgggn accctcagga gggccttgca agtgtgtggg 900 taggnaaaaa actgggctgg gcaaactact tggntncaag tttttttatg ggagaccgaa 960 caacctggga aggcttaaan gcaagnggtt cgncntttaa ttaaaaggct gggccaaatt 1020 accc 1024 2 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 2 gccgtcnaga cctgctcgag cggacgtcng tgcgatggat ntactgcaga nntctccctn 60 ncatcctaan acgactcact atagggcagt gacgaaaggt acnncgngga ngnttnntgg 120 ntangcgatc agctattgna cggaatctct gtganantga nnagctnana tcntctccan 180 ggaanaacag ntccncaang ctntattnga gacagagcta tgacannnnc ntntntactc 240 ngacagtcct taggaaccnc gcaantgana nngnggngat gcnactagga nctgncncnn 300 ntagngagcg agcccggtgg ataactgccc tggtacncng nagctgnaaa gccgcctgca 360 gaccgaacct gagactgacg tcgcctcanc tatngacnnn nnnccnatnn tgagtgnaag 420 cgtnctnatg ngacactcgg ggnccacgat gcanancgct ancnncccnn ggngtgncan 480 tnagnnatcn ttgcncatat tncgnatntt gacatgtgta atgatngaga tctcatannt 540 gcactgtgct tctcatctat taacgctaaa ccatgacagt ttnctttcat tgccacntnc 600 tttcagtgac ccnanatntt atcgctanat attcnatcct tcaacngtag cattnttcct 660 gctnttcttt nccnaaagca tcttctttcc caactcactc cagggccaaa tactctcanc 720 cnnctcactn tangntctcn gntcacggtc tttcccgtga cacgtcattc aattcccctc 780 gnaagctanc ccaggcccaa ctttnntctt cttcaccggn nntaacttaa tcctggggga 840 aggnaangcn nggntcttta gccttgntcc agaaccttng gtagccccgg ncacaaatcc 900 naaaaacctt tgcaggtttg ggggttggac cccgggncct tttttcccgg gtngggttta 960 nggngggaac cgnattttta nnatngacca aggaaggctg gggtcctttg gaaagncccc 1020 cngg 1024 3 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 3 cttggtaccg agctcggatc cctagtaacg gccgccagtg tgctggaatt cgcccttcca 60 tcctaatacg actcactata gggctcgagc ggccgcccgg gcaggtcact gggtttttct 120 ccttttgtag ccttttcctt tagtctcctc ttcccggtgg ttggtaaaaa gaggtgaatt 180 gacagcctat gttgaagaca ctgtgctttt ctcaagaagg acatccaaac agcaagtcta 240 cttctttctc tttaacgatg tgctcattat caccaagaag aagagtgaag aaagttacaa 300 cgtcaatgat tattccttaa gagatcagct attggtggaa tcttgtgaca atgaagagct 360 taattcttct ccagggaaga acagctccac aatgctctat tcaagacaga gctctgccag 420 tcacctcttt actctgacag tccttagtaa ccacgcgaat gagaaagtgg agatgctact 480 aggagctgag acgcagagcg agcgagcccg ctggataact gccctgggac acagcagcgg 540 gaagccgcct gcagaccgaa cctcactgac ccaggtggaa atcgttaggt catttactgc 600 taagcagcca gatgaactct ccctgcaggt ggctgacgtc gtcctcatct atcaacgtgt 660 cagcgatggc tggtatgagg gggaacgact acgagatgga gaaagaagct ggtttcctat 720 ggaatgtgcc aaggagataa catgtcaagg ctacaattgn ttaagaatgt ggagagaatg 780 ggacgcttgc taggactgga gaanccacgt gagncttttn aangggcctt tggtactgca 840 agaattgcac cgacacttac cgggcttggt ggttctgggg ctagtttaat ggnaatttgg 900 cccagncttt ttaattaaag gaccggaaac cntggccttt aactttggcc agtggtncgg 960 tntntnatgg aaaaaacttt gggtaccccg gngttgccca ggttagtttt acctaacccc 1020 cccn 1024 4 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 4 accgnnctcg natccctagt aacggccgcc agtgtgctgg aattcgccct tgtatagtgg 60 tgtgatcttg gctcactgct acctccacct cccaggctca cacgatcctc cagcctcagc 120 ctcccaagta gctgcgacta caggtgcacg ccattgcagc tggctaattt ttgtattttc 180 agtagagatg gggtttcccc atgttggcca ggctggtctt gaactcctaa gctcaagcaa 240 ttcacctgcc tcagcctccc agagtgctgg gattactcct aagctcaagc aattcacctg 300 cctcagcctc ccagagtgct gggattactc ctaagctcaa gcaattcatc tgcctcagcc 360 tcccagagtg ctgggattac tcctaaactc aagcaattca cctgcctcag cctcccagag 420 tgctgggatt actcctaagc tcaagcaatt cacctgcctc agcctcccag agtgctggga 480 ttactcctaa gctcaagcaa ttcacctgcc tcagcctccc agagtgctgg gattactcct 540 aagctcaagc aattcacctg cctcagcctc ccagagtgct gggattacag gtgtgaagca 600 ctacacccag cccattcttc ccttttaacc aaggaagaaa ttacacaatg aaacaaatac 660 cccgaatctt aatatcactt ttcctttgnc ataattaaca attagcgaca cagaatcgag 720 gggaaaaaca caggatccgt ttacttctan gaanggcgtt tctgtgaatc taagaagggg 780 cttttctgng gtctcaaggn cacgggtcaa gccaggtggg ccgcttgcgg ggtgcgctgg 840 ctggggagaa acttntcggg gatnggaagt gaaannggtt ccgnctgggc ccccttnttt 900 tgggaaaccc caggngngtn tngcaaaggc caagggaaag gcctcaaggg ggggcatgaa 960 ctttgnagct tccaactttg gttccnttan acnngggggg gccctnatgg cccaaaaagg 1020 gctt 1024 5 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 5 gccgtcnaga cncntgcngn agcgnncgnc ngtgggatgg nnanntgcng annncgcccn 60 tccntcctaa tacnactcac tataggcgnn agnggccacn tcnagctngn gnnngaagtt 120 ggnntgcngt gnagtctgtn cctgnggcan cgcgtcatgc atgactttgg gtcattgctg 180 ctctccttgc ctttagggga gggtcctggt gctctgtgag cagattngac cctaggggtg 240 aagtcatctn gcccctgttc tgagccgaga gctggncagg gngcgtctca catcattcct 300 ctgcccctgt ngncgcatgg gaaatcctaa acaggctctg tggnaaangc tgnnccaagg 360 cgcctcctgg gcagncganc catcagnnga tcgnnagccn ngaancgatg gcccgggaaa 420 accaaaccag gaannaanca caccgtgcga aaggnattgg tgaacgaact gaaaaattgt 480 aaagctctta aggactttca tgcttgcnag nattnantga canaaaatca ctganncann 540 gaacataaag aaatagccat ggangattca cagtgtanct ngctgancng ctcatntggc 600 cncaagnnat gtttnactna cgnagncnca atganctggt ccttgntnng gctggctttc 660 ttttctgngc aaaacttggn ggncccttaa ttgggcttan cccaacnaca agacttcctg 720 ggaaaacngg gnanntagga antttgnaag gacaaccaaa ggaaactgga agggaacaaa 780 ttttttggtt cccaaaaccg ggccaagatt gggcttcaaa aancctttga accngggggn 840 ncaattnntn gggnttanat cccccgaaag gaanngggan ggtnttnaag gnaaaanccc 900 nnccaaggaa cccnggtttn gggccntgga agggnccctg gncnnggttt cgaggnnttg 960 ncttaactgg aaggncccna aagggaaaac cnnnnntttt tnaagggntc cccggaaccc 1020 aaag 1024 6 957 DNA Homo Sapien misc_feature (1)...(957) n = A,T,C or G 6 acgcggggac acacagaggc gggcatttcc ctgacgactc gtgtgtgccg tgggggagcg 60 gtagatggcc cagccccaag tgttccgatc ttcctgccca aacatattct gtgacggaaa 120 gcctatgttg acctcgtccg gcactcaagg cgtgggcagc ggcctaacgt ctgctgcggg 180 aacacagtcg cgttgaatgc tattctcaag acagacaaaa cagtgggaag acactacgcc 240 aagctgctaa ctccctggcc attgccggac tctttcaccc ccatggactt tccgctggca 300 ttttaaacaa catagtttct tttctctgtc tctttctctt tccctctctc tttctctttc 360 tctctctctc tctctctctc tctctctctc tctcaatctc ataatttctc tctctcgtgc 420 cacgttccca cccaacgctc tctcgcccac ttctactggg gcccacttcc tctcctgctc 480 tctctgtctc aacgtgattg actttcttgt gctgcncagg acttcttgcc cacgtgcgcc 540 ttcaanacgg taaagagctg caactgaacg tgtgagacat ggtgcanata aggctgagag 600 ggcggnggga gagatgccca tgaactcaag tacctgcccg ggcnggccgc tcgaaagggg 660 gaattccagc aaactggcgg ccgttactan tggattcgng ctccggtaca ngcttggggt 720 aatcatggtc aatanctggt ttcctgtggt naaattggtt ntccggctca nnaatttcaa 780 nannanatan naagcncggn aancataaan ttgttaaagc ccnggggttc cctnaatnan 840 tttgncctan tnnaacntta aattngngnt ttnncnncan anngncngnt ttttcaattc 900 cgggaaanct ngtcntnngn agctngcatt atcnanttcg ggccaaangc gcggggg 957 7 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 7 cttggcaccg ccctcggatc cctagtaacg gccgccagtg tgctggaatt cgccctttag 60 agtatagtgg tgtgatcttg gctcactgca acctccacct cctgggttca agcaatgctg 120 cctcagcctc cccagtagtt gggactacag gcgtgtgcca ccacacccgg ctaatttttg 180 tatttgcagt agagacgggg tttcatcatg ttggccaggc tggtctcgaa ctcctggcct 240 caagtgacac gcctgcctca acctcccaaa gtgctgggat tacaggcgtg agccaccgca 300 cctggcctct atgctcgaat ttctactctt agctaatctc tctaacacat atgcccttca 360 ttgggtaaag ctggctcagc agactaatta cacctgtcat gtaatacaag cctctccctg 420 gcctgtatta tctcatggtt gccttctatt tgtgacaagt gctatgaata ttccttttta 480 agaagtgata caaaatcttt ttttttttct tgaacaggat ttttaactca gacagtgtaa 540 acatcatgac aattctggaa tgtctgaagt ttgagataga agattgtcta agaaaagctg 600 agattgnctt agctgtttgt ggtatccgaa ttcctctgga acatgggcat caggaaccaa 660 gcgatgccac tgctactggg cagggttttt atattttacc taaacagaga ccaatgacgc 720 tgacctacct taatgaaaat ttcagaaaaa ccatctggaa tcagccccat catgtccaga 780 attggaangg aatctgggga tcaatggaac atacccggaa atacttttnt ttcccccaaa 840 ccaaggnaat ggaatgtcaa aagtattgga gcctaattta aaatggggnt tccntantaa 900 agntttgctt tcanttaatg ggancanttg gcnanntggt tttgggnacc cctgcataat 960 ttaaaccgng nggccagttg gccaaccaan atttcancng gaaagggggt attttaaaag 1020 cccg 1024 8 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 8 tagangcatg ctcgagcggn ccgtcngggt gntgganctn tgcgagactn ngcccttnca 60 tactangacg actnactata ggnnnngtnc agtgcgtcgc gatcgggtgt agggttatan 120 ngcngnnggn ntnctnttgg agagntnngn ngctnanctg ctatgntctc ntggatnnnc 180 tntgcccgca gaaaatnaat gcgttttgaa cagttttagn tttgtgcctc atanattgtg 240 tnantgctat ncattatnnn gnntgcatat ntantctnna nngccnncaa ggcatcgcng 300 atggnctaac atctcaaaac nccttancct acanntganc nntgtggnan actttgnngn 360 ggnantgtgg ntaaaagnac canggggnna atcntggntc agancnctan aaagcattgn 420 ttactacaac tggctcttga atatcccctt gcgctgatat ttgtggtcag ctgcctacag 480 ttgaatatgc agcgtnacac anncnaagct gccagtgcta caattaactg aagcatnact 540 tantntgtaa ncacnatcta anttngcatc agtnctcatg acatncatta catgggacag 600 gggcaagagc agtagctctg gtatgtgaca ttgatcccca gatgccttcc caatctggac 660 atgatggggc tgnnttccca atggttacnc tgaaaatgca ttaagggagg tcagcgtcat 720 ttgtctcatg gatacgnaaa aatctcttnc accctgncca tnaacaggng gcaatcgctt 780 gnggncctga tgnccatgtt ccaaaaggaa tccgatgcca nnagcngctg ggacagtctt 840 aagcttttct tcnccaccct tctatcttga acttncanac gtttccggaa acnccaanga 900 nngttaccac ttgccngacc taaaaaacnc tgttcacgaa nttnaacttn ggatttngga 960 acnctttctt tanaaagggt tatccattgc nctttgtgnc caaataggan ggccnccctt 1020 nnga 1024 9 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 9 accgccctcg natccctagt aacggccgcc agtgtgctgg aattcgccct ttagagtata 60 gtggtgtgat cttggcccac tgcaacctct gcttcctagg ttcaagtgat tctcctgcct 120 cagcctccca agtagctggg attgtaagag tatgccacca cgcccagcta ctttttgtat 180 ttttagtaga gacagggttt catcatgttg gccaggatgg tctcttaact cctgccctca 240 agtgatccac cagagaggag atcctcggcc tccccaagtg ctgggattat aggcatgagc 300 caccgtgccc agcctacttt ctaattaacc aaaaaaaaaa aaaaaaaaaa aaaaaaagcg 360 gccgctgaat tctattctag aattaagcgg ccgctgaatt ctagacctgc ccgggcggcc 420 gctcgagccc tatagtgagt cgtattagga tggaagggcg aattctgcag atatccatca 480 cactggcggc cgctcgagca tgcatntaga gggcccaatt cgccctatag tgagtcgtat 540 tacaattcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg cgttacccaa 600 cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga agaggcccga 660 ccgatcgncc ttccaacagt tgcgcagcct gaatggcgaa tggacgcgcc ctgtagcggc 720 gcattaancc gccggcgggt gtggtggtta cnccgcancg tgaaccgnta cacttggcan 780 ggncctacgg cccgnttcct ttcgctttct ttcctttcct ttnttggnca cgtttcggcc 840 gggttttccc cggtnaagct nttaaattng ggggcttccc ntttangggn tcccgaantt 900 anngccttta acgggaccnt gganccccaa aaaactttgg tttanggggg angggttcac 960 cgtaannggg nccatttgcc ctggntaaac nggttttttc ccccnttgac nttgggnanc 1020 cccg 1024 10 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 10 gccgtcnaga nccatgcnnn agcgngcggc ngtgtnatgg nnanntgcag aanacgncct 60 ncnatcctaa tacgactcac tatagggctn gagcggncga ccggacagng ntnnnggtgg 120 ctnatgccta naatcccagn acttggggag gccnaggatc tcctntntgg tggatcactt 180 gagggcagga gttaanagac catcctggcc aacatgatga aaccctgtct ctactaaaaa 240 tacanaangt agctgggcgt ggtggcatac tcttacaanc ccagctactt gggaggctga 300 ggcaggagaa tcacttgaac ctaggaagca gaggttgcag tgggccaaga tcacaccact 360 atactctaaa gggcgaattc cagcacactg gcgnccgtta ctagaggatc cgngctcggt 420 nccaagcttg gcgtaatcat ggacanagct gttncctgtg tgaaatgggt aancgctnac 480 aanntnacac aacatacnag ccggaagcat aaagngtnaa gcctggggng cctaatgagt 540 gagctaactc acattaattg cgttgcgctc actgcccgct ttncagntcg ggaaacctgc 600 cgtgccagct gcattaatga atcggccacg cncnggggag aggcggantg cgaatgggcg 660 cttcttncgn ttctcgctta ctgactngat gcggttcggc ccattgnntg cagcaaagcg 720 gnatcngctc acttnaaagg cnggnaatnc cggttntccc cntgaatccg ggggattacc 780 gcaggtnaag aaccatgggg anccaaaagg ccagctaaaa gggcccggga acccggaaaa 840 aaggcccngt tggttggcgt tttttcanaa ggttccgccc ccttgaccgn ngcnttacaa 900 aaattnggag gcnttaaggt cnnaantggg ggaaaccccc cgggaaattt caggntnccc 960 nggggtttcc cctgggaagt tncttngggg gctttccnnt tcnaaacctg gcgnttaccg 1020 gnaa 1024 11 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 11 gtncgtctag atgcatgctc gagcggccgc cagtgtgatg gatatctgca gaattcgccc 60 ttgagcggcc gcccgggcag gtacgcgggg gggcatttcc ctgacgactc gtgtgtgccg 120 tgggggagcg gtagatggcc cagccccaag tgttccgatc ttcctgccca aacatattct 180 gtgacggaaa gcctatgttg acctcgtccg gcactcaagg cgtgggcagc ggcctaacgt 240 ctgctgcggg aacacagtcg cgttgaatgc tattctcaag acagacaaaa cagtgggaag 300 acactacgcc aagctgctaa ctccctggcc attgccggac tctttcaccc ccatggactt 360 tccgctggca ttttaaacaa catagtttct tttctctgtc tctttctctt tctctctctc 420 tttctctttc tctctctctc tctctctctc tctctctctg tcaatctcat aatttctctc 480 tctcgtgcca cgttcccacc caacgctctc tcgcccactt ctactggggc ccacttcctc 540 tcctgctctc tctgtctcaa cgtgattgac tttcttgtgc tgcccaggac ttcttgccca 600 cgtgcgcctt caaaacggta agagctgcaa ctgaacgtgt ganacatggt gcagataggc 660 tgagaggcng cgggaaaaat gcccatgaaa ctcaaagtac tccngccggc gancacgcta 720 angggngant ttcaagcaca nntggcgggc cgttactaan tggattcgaa cctccggtac 780 caaaagcttg ggcgttaatc atgncaanaa gccgttttcc ngtnttaaat ttgttnancc 840 gctcananat tccanacaan cnattacnan gccgggaaan ccaanaaagt tgttaaaacc 900 ctgggggttg ccnnaatgan ttgangctaa ntccnnttta atttncnttg cnccnaangg 960 ccggtttttc cattcgggaa acctgtncgt nccaanctgn atttantgaa tcgggcaaac 1020 tccc 1024 12 957 DNA Homo Sapien misc_feature (1)...(957) n = A,T,C or G 12 actttttttt tttttttttt tttttttttt tttttagctt tatttttatt gttgacacta 60 ttacagatag aatgaccaca accatattaa caaaccaaaa acctgtgcac agaaacaaga 120 tgaagaaaat atatcaagat gttaaccaca ctctttggat ggtgaaaaca tgggtgagtt 180 tctcttctac atttctgtaa cttcaaagtt tctataatga acacatttca tatataatgg 240 aaatatatgt agtaaaggtg gactaccaaa acactagaat gatgaccttt caaggaaacc 300 gaaacaaaat aaccataatc ccacaacaac cacacaacta tttcttgttt ttcatctttc 360 ttcccatctt tgacatttat gcatacttat cactaacacc ctaataatca cagactagtg 420 cacagatcaa gatgttaaca gttaattgtt gttgggtgtt gggaatatgt gtgaattttc 480 tttactgaat ttccaaagtt ttgtatgagt atgtantata tttgtaatgg aaaatacata 540 cataagaatt tantaccaaa nacaccaaag attatttaag gaatttgaga caaaaatatt 600 tanccaaatt cccacaatga caacaccaan tttaggtant ttccacatct ntttcaaatt 660 taanggcttt angcacacat attttaacac tggtanccac aagcngtgtt gcnccggaan 720 caanngntng agggaaacca ggtncaagga tggtnancan taagttgtta anggggttgg 780 gaanannggn aattttttaa aacanattta cnttaanttt ccaagttttn ccnccgggga 840 anntttttng gccaccaatg ggggnncccc nttatanccn ngtnanccgg ggacattttt 900 tnnnggggaa atttnganaa atttagagtg ngaaangntt tttacccaan agtnccn 957 13 1020 DNA Homo Sapien misc_feature (1)...(1020) n = A,T,C or G 13 gtgngtctag atgcatgctc gagcggccgc cagtgtgatg gatatctgca gaattcgccc 60 ttcgagcggc cgcccgggca ggtacccagg attcaaaagt catcttcccc ggcgggaggc 120 aagggacgct tatggagaac ctcttaaaga tattgtgagc attctactca ttacttaggg 180 aaagagagcg ggtgttggtc caactctggc ttttgtgcca ggtaggagtt ggtcctgagg 240 ccgcccatct gaccatactg gacctgtttt aaggtttttc tctaaaaaaa ttttagattt 300 gtcaatctgt gctcctgcag gggatgctat gtccaaatgt cccaggattt gtttttttct 360 gtctttcctg agacattccc tgcccagcta cccaaggaat ccttcaaacg agcaaatctg 420 accatatctt ctatggtcag attaaaatct tccatggctc cctattgctt atgggacaaa 480 atcaaaattc ctgagtctgg tctaaaaggt gtttgatgat cttgacctgc tgactttgcc 540 agccttcttg tcagactctc gtgtcatgct ccgcctagac tatgagcctg ctatttcata 600 ctatgtagct ttgtaaagtc ccagaaaatg ctgggctctg actcttttat aactttacat 660 atactgttcc atctgcctgg aatgccttct acttgtctgt ccagcaaatt ctcaactcat 720 ctcttaaggg cccagcttca attgccgcct cctancataa gtcttccctt gatttcccan 780 gcagnaatta nntcccgcgt accccgggga ntcccaatca gtttgtgctt tcaaaactga 840 tggnnngact tccctgaaat ttgggttacc ncaaaacgaa atgggtgaat ccnnttcccc 900 cgggggggct gcaattgcac ccttttttaa aggggaaccc tgnaantccc aatggnttaa 960 atttgacncc cttaanggcn tnanttcnat tgagcaactt naaaaggggt tttttttttt 1020 14 1013 DNA Homo Sapien misc_feature (1)...(1013) n = A,T,C or G 14 gtgtcgatgc atgctcgagc ggccgccagt gtgatggata tctgcagaat tcgccctttc 60 gagcggccgc ccgggcaggt acctcattag taattgtttt gttgtttcat ttttttcnaa 120 ngtctcccct ctacnagctc acctgagata acagaatgaa aatggaagga cagccagatt 180 tctcctttgc tctcngctca ttctctctga ancctaggtt acccattttg gggacccatt 240 ataggcaata aacacagttc ccaaagcatt tggacagttt cttgttgtgt tttanaangg 300 ttttcctttt tctnancctt ttcctgcaaa aggctcactc agtcccttgc ttgctcantg 360 gactgggctc cccagggcct aggctgcctt cttttccatg tcccacccat gagccctcna 420 ctagacagct cantaagcct ggcccttcat tctgcgctgt gttcttcctc ngtgaaaatc 480 caatacctct tacctcctct gcatgcaaag attctcaagg attgtcagac ttcaaacgta 540 acagcagaac caccagaagg tccnataaat gcagtagtga ccttctcaag ctgtcaggtc 600 tttaaatagg atttgggatt taatgcnatg tatttttaaa ggaaagaaat aagagttgcn 660 agtttaaaaa tgcatgtctt ttagccaatt cagaatcctg cccccaaact tttttaaaaa 720 gtcaagacag ataaagcttt ggggganacg gaaaaaaann gnnnaaaaaa anaaagtact 780 tcgggcggna acnacgctaa gggnnaattc agcananggg gggccgttac aagngggttc 840 nanncccggt acnaancctt gggggtttaa caagggcnaa ancnggttnc cggggntnaa 900 aattgttacc cgcnaaaaat tccanaaaaa natncgaacc cggaaancca taaanttntn 960 aancccnggn ggccnaaggg agngnnnaac cccnaataaa tggnttggnc cnt 1013 15 951 DNA Homo Sapien misc_feature (1)...(951) n = A,T,C or G 15 accctagggc aaatactgag cagggtaaaa ttcccagaat acccactaga agcgtggaat 60 atatcaatat cctaggaaga agattcagca caccaaattt cccattactg ataacagctc 120 tgaaggcata ataagaaagt gagtgatcag aagagcagag aaatgacttg ttccagtcac 180 tgccatcttg tttacccttt cagtggttcc cttacccttt tccccactgg gcatacagct 240 catctctctc tgagtccttt tctgctttcc tcctttgctc taaacgttcg agtttcaaat 300 tcctcttacg accagactta tctcgaaata cggtttcagc atattgaaat tcagctgcaa 360 aggaaaatta tactcaaata tcaggatcaa aatcagaaat aacattctaa gagatcaaat 420 caaccgcttg ggattctaat gctagataag aacttctgca gccagaccaa agtagttcct 480 accaacatct tggtgcatat tggcactggg cccaagaaat ggcattttcc tttttttttt 540 ttttgagatg gagtctcact ctgttgccca ggttggagtg cantgggcgc gattttggct 600 cactgcaacc tccacctccc aaggttcaag cgattctcct gtctcaagcc tcctgagtna 660 gctggggaat acagggcata cnacancatg cctggctagt tttttttttg gaattttggn 720 tagagacagg ggtttcatca nggttngccc aggcctggtn cttggaactn anagaccctc 780 aggntggatt caacccaact tccgggctac caaaaggtng ncgngggatt acangcattt 840 anncaacngn gccctngggc naaaatggna anttttcang aagggaaagc agcnntgggg 900 atcccnggnn naantttcac caaggcctta aaccagggnc gtaaatttgt t 951 16 1008 DNA Homo Sapien misc_feature (1)...(1008) n = A,T,C or G 16 gtgcgatgca tgctcgagcg gccgccagtg tgatggatat ctgcagaatt cgccctttcg 60 agcggccgcc cgggcaggta cattacttgg tgttaacatt gttggcagtg gtagcccctt 120 ttcagaaagc aacttgctgt aagtcagggt gtccgttcca accttcagct agtgaaaagg 180 tagtaacaaa tggtaaacaa gagaatgatt gtttaaacct atctgtggac acttaatgca 240 actgtttaaa aatgataatc acgagttatg tagcaacgtg gaaatatatt tacagaacat 300 taagtggaga aagcaggaca cgaaagtata tttatactac agttataact caacagttca 360 tttatatgct gttcatttaa cagttcattt aaacagttca ttataactgt ttaaaaatat 420 atatgcttat agtcaaaagc tgttgtggtg ttgttgttgt aggcttatag ttgagcatta 480 ttttcttaaa tttcttgaat gttctttatg gtagtgttac taaaaagttt atgatcacat 540 tttcattgtg aacataattt gaactcatta tcacacactt ggaaaataca gaaaagtgga 600 ggaaaaaaaa tcatatcccc ancatccaaa gacatatact ctcctcttat cctgttcaat 660 cctggtttcc ggtgcacaag gtttatgatt ataactgtgt caaaatgtat aatcaaaata 720 gctgttacat taccttggtg gnantaaggg taaatacctt caccttaaat ttttcaaaan 780 gttcccaana ataaaggtcc ggataacagt ggtataagtg tgtcccaatt gggggtgcan 840 aatacattcc cangngggaa aatttnnaaa tnaagttaaa ttattttaaa aaatttccaa 900 aattcccaan anctaanaac taangggnaa aaacctngat cgggntnccc caaacnngtt 960 taantgnnac nccttgggaa aanaagnttt aaaaanggtg gcaaaaag 1008 17 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 17 gtgnctctag atgcatgctc gagcggccgc cagtgtgatg gatatctgca gaattcgccc 60 tttnnanagg ncgcncgggc angnantctt cccncctntg ccatnannca cggnnanaan 120 cngcagtggc actaantntg agacaatctt ncaaaccagc ttcatgtcgc tncacttntc 180 nnngtncaag angagggcca ggangggaaa catcacanct gcgctaagnc cngntccggg 240 nngtcagcat nngntctgtt ncaanncccn cgntcggtcc cctcatccta ctctgcctcc 300 natgactttg cncctcagac ntcntggaac naaggnttcc nggggggcac accgcgtccg 360 gccgnnnntg tctcggggcc acttggcgtg tgtgataaat caatcaagct gttnanntcg 420 nacgagtctc nggtngcctg cananntaag cctcatcatc agagcctttc ctcaaaactg 480 gantcccana tgtcatcagg ttntggttnt tttcagccan naggaagccc tcngcattga 540 atccnagaac ttgggcatgg tnnaagatct acaagntnga atacgctgcc cgcnanaanc 600 nttcaaccct aacaggaagg tnggattcaa ggaaggtgta anggnncatt annccacncg 660 ggggnaccaa gggagntana antanncatn nntttgggtt cgcccnccga agggnnttaa 720 cccccggaat tnnntttnng ntnaaggggg gnnnngggna aatcccngtt cnncatttgg 780 gaaagggann ccttnccttn cnntnggcct ntaaaagnnt tancaanacc cgnnatnntg 840 ttnanggccc cgnttttcaa nggggttaan nnnttngggn aacccccnnc cccaaagnng 900 gnnnaanggg ggnaattccc aanaaaacng gggggnncct tnnnnnangg gnttcngnnn 960 ccccnaaagg nnncntgggg ggnnannann gnncnaaaaa gggttcccnn nnnnaaattt 1020 tttc 1024 18 981 DNA Homo Sapien misc_feature (1)...(981) n = A,T,C or G 18 acgcgggaca gagagaaggt taagagcaac aagatgggag gcagctgcat ggaacctgtc 60 ccactgagga agtaaaacag agttttactc ttgttgccca ggctggagcg caatggtgcg 120 atctcggctc accgcaatct ctgcctcctg agttcaagcg aggagcaacc ctacctgatg 180 gactggactt ctgcctggat tggagtttga tcatgcctcc atatgggtgt ttaccaggcg 240 tatgcattga acctgagttt gtctcttcaa tacaaggaaa atctctgccg cttagtgatt 300 ttccaagaaa catgagcttc tgcctttcaa tgaggaagat actcagaagt catgttcgag 360 cactccggaa aatgtccttg gagtttcaac atttctttgg tcttccacat ttcattttgt 420 cctgattaaa gaggaagcca agttgctgtt tgtgtggcca tgtgagcagg canggagatg 480 gtggctgcct agaagccaag agaagtggcc tcaagatgaa atctaccttg ctggtactgc 540 ccggggcggc cgcccgggca aggtacnttt tttttttttt gttttttttt ggcaaaaagg 600 ctgtaaagct tttttgggga gaaattttaa tgggncaaan tttccaacac aggnagcanc 660 cctgaaacca attttaagcg ggtccttccc ttttaaggct gtnnaattgc cccttcaanc 720 ttcctcaagg ngtttttcac cctcccnccg ggattttggn aaaggcccaa aantccntgg 780 gnnaanaagg gacaatctcc cgggnttaaa aaccaattnt ncggggngna accnggttcc 840 ctgggctann cncctttaan ggntnccggg gcccttttgn gggggnaatt ttcaaacggn 900 ncctncattt tctnaggggg naanccncct tngggtcann gggncnannn cccaagnctt 960 caaanccnaa ntcttttggg g 981 19 980 DNA Homo Sapien misc_feature (1)...(980) n = A,T,C or G 19 acttttttct tttttttttt tttttccgtc tccccaaagc tttatctgtc ttgacttttt 60 aaaaaagttt gggggcagat tctgaattgg ctaaaagaca tgcattttta aaactagcaa 120 ctcttatttc tttcctttaa aaatacatag cattaaatcc caaatcctat ttaaagacct 180 gacagcttga gaaggtcact actgcattta taggaccttc tggtggttct gctgttacgt 240 ttgaagtctg acaatccttg agaatctttg catgcagagg aggtaagagg tattggattt 300 tcacagagga agaacacagc gcagaatgaa gggccaggct tactgagctg tccagtggag 360 ggctcatggg tgggacatgg aaaagaaggc agcctaggcc ctggggagcc cagtccactg 420 agcaagcaag ggactgagtg aagccttttg caggaaaagg ctaagaaaaa ggaaaaccat 480 tctaaaacac aacaagaaac tgtccaaatg ctttgggaac tgtgtttaat gcctataatg 540 ggtccccaaa atggggtaac ctagacttca gagagaatga gcanaganca nagggagaaa 600 tctggctgtc cttccaattt tcaatccgtn atcccaggtg aagctgggta ngagggggag 660 ancattngna naaaaatnga aacaacanaa nccagtttac taaatnaagg gaacctgccc 720 cngggcgggc cnccaanggg ccaaatttca ancaacanng ggcgggcccg ttaccaantg 780 gnattccgaa gccncgggta accaangcct nggngtnaat ccagngggnc aaanccngtt 840 tnccnggngt gnaaattggt tancccgccc naanaattcc acancaacga atcngaagnc 900 cgggcnagca tnnangnnta aancccgngg ggggcncaaa agggaatgnn nccanacccn 960 attaaatncg gttgcccctg 980 20 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 20 cttggtaccg ngctcggatc cctagtaacg gccgccagtg tgctggaatt cgcccttcca 60 tcctaatacg actcactata gggctcgagc ggccgccggg caggtattca gcggccgctt 120 tttttttttt tttttttttt tttttttttt attgntgaca ctattacaga tagaatgacc 180 acaaccatat taacaaacca aaaacctgtg cacagaaaca agatgaagaa aatatatcaa 240 gatgttaacc acactntttg gatggtgaaa acatgggtga gtttctcttc tacatttctg 300 taacttcaaa gtttctataa tgaacacatt tcatatataa tggaaatata tgtagtaaag 360 gnggactacc aaaacactag aatgatgacc tttcaaggaa accgaaacaa aataaccata 420 atcccacaac aaccacacaa ctatttcttg gttttcatct ttcttcccat ctttgacatt 480 tatgcatact tatcactaac accctaataa tcacagacta gtgcacagat caagatgtta 540 acagttaatt gttgttgggt gttgggaata tgtgtgaatt ttctttactg aatttccaaa 600 gttttgtatg agtatgtatt atatttgtaa tggaaaatac atacataaaa tttattacca 660 aaacaccaaa gattatttaa ggaatttgag acaaaatatt taaccaaatt cccacaatga 720 caacactatt ttaggtattt tccacatctt ttcatttaag actttatgcn cncatattta 780 acactggtat ccacaagcgt gtgccctgaa accaggatan nggggaaacn ngatcaagat 840 gttagccagt agtttggtag gnggttggga aatataggga attttttnaa aaaaatttac 900 tttatttncn aaattttccc cttgggnaag ggattatggc ncnccaangg gngccccctt 960 aaanacnctg gttttcngga cctttttttt nggggaccat ttggaaaaaa ttaangggga 1020 aggt 1024 21 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 21 nagnngcang cncgagcgcg cgccagtgtg atggatatct gcngaattcg cccttcntan 60 cngnngncac tnaatgcang ngcnnaacca tgataacccg agttatgctn agcanaggaa 120 ctatatgtac agaaacatta agtgnngaaa gccnnacncn anggnanntg aatactacng 180 tnataactna ncagaccatt nanatgctgc acatttaaca nnncntncan acagnanatt 240 ataanngnnt ananntatat atgctnatng accaaagctg tngaggggtn gccgttgaag 300 gcnnnnngnt nagcattanc atnttacnnc acttgcctgn cctntatggc agggttacta 360 tctttgttac tgatcacgac atcantgcga acntaanacn aacncnntat nacacactng 420 nnanagcccg aatcgngnng gaacagtatc ntntcnccnc canccnnaga catntncnnn 480 cctcttatcn tgancattcn agnttctgtg cacaggtnta tgatnntanc ngtgncaaan 540 tgnntcttna aantanttgc cacatnacct tngaggantt atggannaan actctcactt 600 taaanccnnc aancgacccc nanaanactg tnctgntaac agtgcanaat gtgtgatttc 660 atagttntgc acacacatnc ccacnggaan cacaggcgtg tgcactgaac attntagagg 720 ntacctatct gccgacacct aacactacng gtnacggcaa gatcggaacc tntaannggg 780 ttaacncaaa cnctagggat acccngggaa atatgtggcc caccgtttaa acccccgaag 840 tgcccngtac ccnggacatt gttttcgtgn cggtanttgg gttaaanntg ggntnaaaac 900 cctaattccc cctgggggtt tgccactaaa tttgaaggac cttttggccc tgccaaaatc 960 annaaccctg gcncanaact ttggggganc nggnnaggna gggtnnccct ttttttccga 1020 aggc 1024 22 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 22 gtgcgatgca tgcncgagcg gccgccagtg tgatggatat ctgcagaatt cgccctttcg 60 agcggccgcc cgggcaggta cttttttttt tttttttttt ttttttttag attccacata 120 tgagtaaaat catgtggtat ttgacttgcc ttttaaaaca cagtgaagaa tctgtcttac 180 tttattcagg gtaggagaag ctacctgggc tccccataaa tgaggtgctc catcccatca 240 tacagcccca tcatattcag tgcttcccag atgacctcct caggggtgca gtagccctct 300 atgaagatta tgcttaggat aagtatgaga atgccagtct tgggcatgct ctggacatca 360 ctcagcatcc catcataggt gaggcccagg gaggtgacaa ggacaaagga gtggccagtg 420 ggatccactt cctttacatc aatgccaaag accagcagca tgcactcgga ggcttcacta 480 aacaacaaag ggaagtggtc ttcataattt tttatgacac tctccaagta tttctgcctt 540 tgtgatcggc tccttcattt gatacttgaa gagcagaaac tgcaccaaat cagtcacctt 600 ttcatctatc tcacttctgg gtaaagactc actgtctggc aaggacctgg tagggtgctt 660 gggactcccc tccttttggc tgcnggagnc ctcancagat tgatctaatg gaagggaaac 720 aacgacccna ggggaaggag cagggctatc tngagcaacn ctggggaagg atttggggtc 780 nccatcatca ngcagnaaac tccctcccgg gggtnccttg ggnanttaaa gggatnccca 840 ggaaggagga nggagggaan agggaggang agggaaaaac naggntngga aaaagggacn 900 cggngggaaa ttggggntta tacaccgccn ncnnnaannn ggggngagnc ngnngnccng 960 tcgnggncnn gnttccnntt gggngaagnn ggnttctcnn angggncgnn nnnnnnnnnc 1020 cnnt 1024 23 948 DNA Homo Sapien misc_feature (1)...(948) n = A,T,C or G 23 acttttttct tttttttttt tttttccgtc tccccaaagc tttatctgtc ttgacttttt 60 aaaaaagttt gggggcagat tctgaattgg ctaaaagaca tgcattttta aaactagcaa 120 ctcttatttc tttcctttaa aaatacatag cattaaatcc caaatcctat ttaaagacct 180 gacagcttga gaaggtcact actgcattta taggaccttc tggtggttct gctgttacgt 240 ttgaagtctg acaatccttg agaatctttg catgcagagg aggtaagagg tattggattt 300 tcacagagga agaacacagc gcagaatgaa gggccaggct tactgagctg tccagtggag 360 ggctcatggg tgggacatgg aaaagaaggc agcctaggcc ctggggagcc cagtccactg 420 agcaagcaag ggactgagtg agccttttgc aggaaaaggc taagaaaaag gaaaaccatt 480 ctaaaacaca acaagaaact gtccaaatgc tttgggaact gtgtttattg cctataatgg 540 gtccccaaaa tgggtaacct agacttcaga gagaatgagc agagnagcaa aggagaaatc 600 tgggctgtcc ttccattttc attccgttaa cctcaaggtg anctggtaaa aggggagaca 660 ttagaaaaaa aatgaancaa caaancaatt actaatgang tacctgcccg gggcggccgc 720 aaagggcgaa ntccaagcac acngggcggg ccgttacaan tnggatttcg aacccggtac 780 caaancntgg gngtaaanca ngggncaana accggnttcc cgggggtgaa aantgtttat 840 ccgcccaaaa attccaaaaa ancaatanga aaccggaaan cataaagtnt taaaccctgg 900 ggggggccca aangantgag ccaaanccca attnaattgg gttggncc 948 24 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 24 taccgccctc gcatccctag taacggccnc cagtgtgctg gaattcgccc ttcctatctg 60 tggacactta atgcaactgt ttaaaaatga taatcacgag ttatgtagca acgtggaaat 120 atatttacag aacattaagt ggagaaagca ggacacgaaa gtatatttat actacagtta 180 taactcaaca gttcatttat atgctgttca tttaacagtt catttaaaca gttcattata 240 actgtttaaa aatatatatg cttatagtca aaagctgttg tggtgttgtt gttgtaggct 300 tatagttgag cattattttc ttaaatttct tgaatgttcc ttatggtagt gttactaaaa 360 agtttatgat cacattttca ttgtgaacat aatttgaact cattatcaca cacttggaaa 420 atacagaaaa gtggaggaaa aaaaatcata tccccaccat ccaaagacat atactctcct 480 cttatcttgt tcattcttgt ttctgtgcac aggtttatga ttataactgt gtcaaaatgt 540 atattcaaaa tagctgttac attacctttg tggaattatg gttaaatact ttcactttaa 600 ttttttcaaa tgttccctat aataatgtcc tgataacagt gtattatgtg tgtctccatt 660 ggtgtgcata atacataccc agaggaaaaa ttagaaaata aagtaaatta ttttaaaaaa 720 ttacctatat tcccaacacc taacaactac tgnttaacca tcttgatctg nttcctctat 780 cttggttcag tgcacacgct ttgngaataa cagtggttaa atatgtgtgc cataaaggcc 840 ttaaatggaa aagatgtggg aaaaataact taanaataag ggtggccttt ggggggaaat 900 ttggttaaaa aattttgggc tcnaaaattc cnttaanaaa acctttgggg ggtttgggna 960 ataaaaatnt taanggangg aatnttcccn ttccantttt nattccttcc tcttcccaaa 1020 actt 1024 25 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 25 gccgtcnaga cncatgcncn agcgnncgnc ngtgtgatgg atatntgcng aattcgncct 60 tccatcctaa tacgactcac tatagggctn nagngngcca ctattncnga tngaangacc 120 acngccatat taacaaacca aaaacctgtg cacagaaaca agatgaagaa aatatatcaa 180 gatgttaacc acactctttg gatggtgaaa acatgggtga gtttctcttc tacatttctg 240 taacttcaaa gnttctataa tgaacacatt tcatatataa tggaantata tgtagnaaag 300 gnggactacc aaaacactag aatgatgacc tttcaaggaa accgaaacaa aataaccata 360 atcccacaac aaccacacaa ctatttcttg gttntcatnt ttcttcccat ctttgacatt 420 tatgcatact tatcactaac accctaataa tccagactag tgcacagatc aagatgttaa 480 cagttaattg cngntgggtg ttgggaatgn gcgtgaattt tctttactga atttccaaag 540 ttttgtatga gnntgtatna natttgtaan ggaaaataca tacatnaaat ttattaccaa 600 aacaccaaag attatttaag gaatttgaga cnaaatattt aacccaaatt ccacaatgcc 660 aacactnttt taggnatttt ccacatcttt tcntttaaga ctttatgcnc cccataatgt 720 aacactggta tcacaaagcg tgtgcactga aaccagggat nnagggaacc gancaagatg 780 ttnncagnag ttggtangng gatnggaaaa taggnaattt ttaaannaat tnacttttat 840 ttccnanatn tccctttggg gatgncttat gcncccccat gggggncccc ctttanancc 900 ctggtaatca nggccntttt ttttggggaa cttttggaaa aaanttnaag gggaangttt 960 ttacccataa tttccccaaa ggnanggggn acncnttttt ggaanatcct ttnggcncct 1020 tttn 1024 26 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 26 gtgcgatgca tgcncgagcg gccgccagtg tgatggatat ctgcagaatt cgccctttcg 60 agcggccgcc cgggcaggta cttttttttt tttttttttt ttttttttag attccacata 120 tgagtaaaat catgtggtat ttgacttgcc ttttaaaaca cagtgaagaa tctgtcttac 180 tttattcagg gtaggagaag ctacctgggc tccccataaa tgaggtgctc catcccatca 240 tacagcccca tcatattcag tgcttcccag atgacctcct caggggtgca gtagccctct 300 atgaagatta tgcttaggat aagtatgaga atgccagtct tgggcatgct ctggacatca 360 ctcagcatcc catcataggt gaggcccagg gaggtgacaa ggacaaagga gtggccagtg 420 ggatccactt cctttacatc aatgccaaag accagcagca tgcactcgga ggcttcacta 480 aacaacaaag ggaagtggtc ttcataattt tttatgacac tctccagtat ttctgccttt 540 gtgatcggct ccttcatttg atacttgaag agcagaaact gcaccaaatc agtcaccttt 600 tcatctatct cacttctggg gtaaagactc actgtctggc aggacctgta gggtgcttgg 660 gactctcctc cttttggctg ctggagccct caacaagatt gatctaatgg gaagggaaac 720 caaccnaccg aanggggang gagcaggctn ttctgaagca ctctggggga aggattttgg 780 ngtncncnat catncagcan gnaaacctcc cnccgggggt gccttggnna ttananggtt 840 agcaaggang gaggacgnag gaananggan gnangnaggg aaaaagangg attggaaaan 900 agggancctn ggtgggaaat tggggttttn nagcaatccc ccnccaaaaa ncnaggggaa 960 ccctgttcaa cccncanggc cnggnttcca cttttggaat ttgaaanttt cctcaaggaa 1020 ngaa 1024 27 935 DNA Homo Sapien misc_feature (1)...(935) n = A,T,C or G 27 acgcggggtg gggggggtcc tggtctttgg cttctcgact cggtcctgtt tcgacagcga 60 acatgtcgcg gcctgtcaga aataggaagg ttgttgatta ctcacagttt caggaatctg 120 atgatgcaga tgaagattat ggaagagatt cgggccctcc cactaagaaa attcgatcat 180 ctccccgaga agctaaaaat aagaggcgat ctggaaagaa ttcacaggaa gatagtgagg 240 actcagaaga caaagatgtg aagaccaaga aggatgattc tcactcagca gaggatagtg 300 aagatgaaaa agaagatcat aaaaatgtgc gccaacaacg gcaggcggca tctaaagcag 360 cttctaaaca gagagagatg ctcatggaag atgtgggcag tgaggaagaa caagaagagg 420 aggatgaggc accattccag gagaattccg gcagcgatga agatttccta atggaagatg 480 atgacgatag tgactatggc agttcgaaaa agaaaaacaa aaagatggtt aagaagtcca 540 aacctgaaag aaaagaaaag aaaatgccca aacccagact aaaggctaca gtgacgccaa 600 gtccagtgaa aggcaaangg aaaattnggt cgccccacag cttcaaaggc atcaaanggg 660 aaagaatccn tctccaaaag aagaaagatg agggaaccgg aaaacccccc agaaaaggaa 720 aacatctana agccccccaa cccagaaatc tggggataaa ggggctgaaa aataaacccc 780 cntttgggga agntttaaaa ttatgaangg nctggggaaa aaattttttt aaaaaannnn 840 nnnnnnnnna aaaaaanttt cctgcccggg ggggcgccnc naaaggggga anttcaanaa 900 aaangggggc ggtttaaaaa ggggtttcca ccccn 935 28 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 28 cttggnaccg ccctcggatc cctagtaacg gccgccagtg tgctggaatt cgcccttcct 60 atctgtggac acttaatgca actgtttaaa aatgataatc acgagttatg tagcaacgtg 120 gaaatatatt tacagaacat taagtggaga aagcaggaca cgaaagtata tttatactac 180 agttataact caacagttca tttatatgct gttcatttaa cagttcattt aaacagttca 240 ttataactgt ttaaaaatat atatgcttat agtcaaaagc tgttgtggtg ttgttgttgt 300 aggcttatag ttgagcatta ttttcttaaa tttcttgaat gttctttatg gtagtgttac 360 taaaaagttt atgatcacat tttcattgtg aacataattt gaactcatta tcacacactt 420 ggaaaataca gaaaagtgga gaaaaaaaaa tcatatcccc accatccaaa gacatatact 480 ctcctcttat cttgttcatt cttgnttctg tgcacaggtt tatgattata actgtgtcaa 540 aatgtatatt caaaatagct gttacattac ctttgtggaa ttatggttaa atactttcac 600 tttaattttt tcaaatgttc cctataataa tgtcctgata acagtgtatt atgtgtgtct 660 ccattggtgt gcataataca tacccagagg aaaaattaga aaataaagta aattatttta 720 aaaaattacc tatattcccc aacacctaac aactactgnt aacatcttga nctggttcct 780 ctatcttggt tcaagtgcac accgcttgng aataacaagg gttaaaaatg ngngccataa 840 aggtcntaaa atggaaaagg atgtgggaaa aatnacctaa aaataggggt ggccattggg 900 gggnaatttg ggttaaaaaa tttgggctcn aaaatncctt aaaaaaaanc ctttgggggt 960 tttgggaaaa aaaaatttta ggggagggaa ttttccattt ccaaatntta ntccntactc 1020 ntta 1024 29 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 29 taggatncat gctcgagcgg ccgncagtgt gatggatatc tgcnagaata cgcccttcca 60 tcctaatacg actcactata gggctcgagc ggtcgcccag gcaggtgcta acaaaccaaa 120 aacctgtgca cagaaacang atgaagaaaa tatatcaaga tgtaaancac actctttggn 180 tggtgaaaac atgggtgagt ttctcttcta cntttctgcn antncanagn ttctataatg 240 aacacatttc atatgtaatg ganntntntg tagtgnaagg tggactaccg gaacactaga 300 atgatgacct ttcaaggaaa ccgaancaaa ntnaccntan tcccacaana accacannac 360 tattncntgg tnntnatgtt tcttcccatc tttgacattg atgcntactt aggactancg 420 ccctaataat cccagacttn ggcacagatc aaganggtaa cnggtgattg gaggtgggtn 480 gccggaantt ggggtgantg ttntttatgg anttnccann ttttggtang ngattgnnna 540 aaattngaan nggaaacnct tacttnaant tgnttaccnn aacnccnagg atnttttaag 600 gattnggggc cnaaattttt acccaaattc cnncaangcc ancnctgtnt aagtcatttt 660 caaanttttt tcncttaaag accttaaggc cccctaaggt aacctgggaa tanaaggggg 720 ggcacntggn accaggntcc nagggaacng nnccaagant tttccccntt ntttgtttgg 780 gggttgggaa atnnnngnaa attttttaaa ggtaatncac ttaatttgcc aaaggaattc 840 ccttnggggg nggnnttatt gcncacccat gggagacccc cntaaggccc cnggaataag 900 ggcctttttt tttngggacc atttgggaaa aatttaaang ggaaggcnnt ttgnaccctt 960 aatttcccca aggnaaangg aaccncccnt tttgganatt gcattttngg ccccgttttt 1020 aagg 1024 30 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 30 gtgcgctcta gatgcatgct cgagcggccg ccagtgtgat ggatatctgc agaattcgcc 60 ctttcgagcg gccgcccggg caggtacttt aattttgctt gttcaaatga tctacactta 120 cattttgcaa atcttttttt ttaaattttt taaattttat attttttttc cagccaactc 180 aaggccaaaa aaaatttctt aatatagtta ttatgcgagg ggaggggaag caaaggagca 240 caggtagtcc acagaataag acacaagaaa cctcaagctg tgaggtcaat ttgtaattaa 300 aagaatacta agattagatg aacacaacac tcagaaatac tctaggagag ctgaaaaaga 360 aggaacagat gttaacaaaa caaattaagg ctgctgggga acctgagtcc atgttaagct 420 tgggttgact gtaaagaatt tttttttttt taatgcaagt tagacatgga gttagagggt 480 cagataaata acgaagagaa ttaagttagc gatagaaaga tctaaggata ctagctcctg 540 ggcacctagg gtgcaaactg acttgtggca gcataagctg atgctgcaca ggggacccaa 600 gccatgttgc tacttgtcac ttaaggcang aagcgcacaa aggaagtgat gaaagggtat 660 tagcctgcaa cattatttac agcatganag cctctcctac gggtcccaac cttcattagg 720 cactactggt gattcaagtg aatgggttgt aacccantcc ttaaaaggca aaggatgtta 780 ggantttaca gggaaaaaag cttccggggt tttancaatt caccaatcan caaaccacat 840 attgaagttt ggttaaaaaa aaaaanannn anaaaaaagt nccctcggcc gngaaacanc 900 cctaaggggg naaattccag canactgggn gggccgntta caaaggggtt cgaaccncgg 960 taccaaacct tgggggttaa ncaaggggca aaancgggtt ncccgnnggg aaaattgttt 1020 nccg 1024 31 1019 DNA Homo Sapien misc_feature (1)...(1019) n = A,T,C or G 31 gtgngatgca tgctcgagcg gccgccagtg tgatggatat ctgcagaatt cgccctttcg 60 agcggccgcc cgggcaggta ccatgctgac ttcttggtat cttttaaggc ctaattttcc 120 cttccttgag attactgtag tgtgttccag ctaatttcta tttggaaacg agttggaaca 180 gctgaaaact aggtattatt gaaggcaaag cagcctcacg tcagtttttt atcagctcat 240 ttgggaagtt tttttttttt ttttttttta attaattaga aagtaggctg ggcacggtgg 300 ctcatgccta taatcccagc acttggggag gccgaggatc tcctctctgg tggatcactt 360 gagggcagga gttaagagac catcctggcc aacatgatga aaccctgtct ctactaaaaa 420 tacaaaaagt agctgggcgt ggtggcatac tcttacaatc ccagctactt gggaggctga 480 ggcaggagaa tcacttgaac ctaggaagca gaggttgcag tgggccaaga tcacaccact 540 atactctagc ctgggcgaca gaggtgggga aaaaagtagg acccctgtcc tatattcagg 600 tttttctcac atatatgaac ccatctaaat tctacgttgt taaaggtanc ttaggttaat 660 taagtccata cttatttaag accaatatgg ggtgaaatgg gatttttttt taaaaatcct 720 acagntnagg ctttccnact ttccttcnaa atgaggaaaa aaaggtgaca aaaattcaag 780 tgtcaatgtc ccctcctggg gaaanaggtt tanaaaaaca acaggctcaa ccttctgaac 840 tnctaacaan ttcccttnga aanttaacga anccattaaa atcnngattt taaaagagga 900 aaanaaaaaa gttcctcggn cggnnacaan cctaagggng aaattccaca aaaanngggg 960 ggcctttana aagnggttcc nacccggtac aaaaccttgg gnttaaccan gggccaant 1019 32 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 32 accgccctcg natccctagt aacggccgcc agtgtgctgg aattcgccct tgttgttggg 60 tgttgggaat atgtgtgaat tttctttact gaatttccaa agttttgtat gagtatgtat 120 tatatttgta atggaaaata catacataaa atttattacc aaaacaccaa agattattta 180 aggaatttga gacaaaatat ttaaccaaat tcccacaatg acaacactat tttagttatt 240 ttccacatct tttcatttaa gactttatgc acacatattt aacactgtta tcacaagcgt 300 gtgcactgaa acaagataga ggaaacagat caagatgtta gcagtagttg ttaggtgttg 360 ggaatatagg taatttttta aaataattta ctttattttc taatttttcc tctgggtatg 420 tattatgcac accaatggag acacacataa tacactgtta tcaggacatt attataggga 480 acatttgaaa aaattaaagt gaaagtattt aaccataatt ccacaaaggt aatgtaacag 540 ctattttgaa tatacatttt gacacagtta taatcataaa cctgtgcaca gaaacaagaa 600 tgaacaagat aagaggagag tatatgtctt tggatggtgg ggatatgatt ttttttcctc 660 cacttttctg nattttccaa gtgtgtgata atgagttcaa attatgttca caatgaaaat 720 gtgatcatta aactttttag taacactacc aataaaggaa ccatttcaag aaaatttaag 780 gaaaaataat gctcaactat taagcctacc acaaccaaca cccacaacag cttttggact 840 attaagcnta tatattttta acnggtatta atggaactgg ttaaatgaac tggtaaaagg 900 aaccgcatnt taaatggact ggtgnggtta taaccggtgg tataaaaana cctttggggc 960 ctggtttttc ccttaanggt ctgnaaanat attttcncgt ngtccanacc ncgggatatc 1020 aatt 1024 33 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 33 gccntcnaga cncatgctcg agcggncgnc agngtgatgg atatnnngca gagnncgccc 60 ttccanccna atacgacnca ctatagggcn nncnnnntng gcnnctttgn tgcccctccn 120 ctcgnataat anctatatta acgaaattgt nctggccttg agttggctgg agagaaatat 180 tnngagnnnn accngtnnnn ntnngnnatc ngtaaantgt aanagtagnt catttgaaca 240 agcaatnatt naantaccca ctggnggaaa ngngnctgaa tcttactctt ntggatctgc 300 aggantaggg cttgtnagta tgtcaaanat gcnnncagtg tcaangttta ngccnattgt 360 aganctngta gcaggaancn acnntgangg ancnncagaa nggagncctn anacatnncc 420 agatntacga ggngagagga gacanacnga gaaagacacc ntaggnncga nctgnagaag 480 gncaggattc tgagaatgaa ntgcncggnn agtccnganc agattggaaa aggagnttct 540 ganggnatgg tgcacnngag ggctgacngg tangaggnac tgntgttgga acgnacatag 600 cgaaagntgn tgngcagtga ggattactac atgnngaaag gactcttgaa acgaggaact 660 aactgtgatg ncanggctga agtttgggcn nccatacttt gnaggttaca attnttngca 720 gtggncgncc cgtttaaana gccnttttga tggaaantca agggtgnncg gtacnacctt 780 ccntttaggg nacaaggcnt tnccgantgg gtngccagga agaanganng ccnnanccct 840 annnggnggg ccccttaatn gcacngggtg aacaatgcna accctcgggt tattggaacn 900 accgnggana anatggttac cgaaccatta ngtggggnna aacccggacc ccggaaggct 960 tttttnncct cngggtaaaa acttaacaga ccnatttttt gcccgccntt taacangtct 1020 tttt 1024 34 982 DNA Homo Sapien misc_feature (1)...(982) n = A,T,C or G 34 acaacaatct aagcaaatct caaatacaac atacttgtaa ttagaacaca atgcaatgac 60 ttgattttag caagaactag acacttaatt tggtaaaaga aaccaaacaa tgcattatat 120 tgaatactaa gctaagttac cataattagt cttacaaatt ctcaaatttc acaactactt 180 ttgaacatct aaatttaaac ctaaattttt taattaaatg cctgttcaac aaagctaatt 240 ggaacaaaca catttatgta aatttacatt ctagaatacc agggtaaaca aggagacgtt 300 attcaaagat gaatgagaaa gttctattct ttttcatcat ttgtgtgatc aggttgcaaa 360 ggacatgctc tttcctcgat gaaactgatg tcgaattagt ggcagaggtg gaagaaccaa 420 gcacctttct gggggctcga gcagccacca cttttctgta agtgcctggg aacactgtct 480 gctttagtcc gcaccatgtt caaacaagaa gagaggagag gagagaacga actgacttcc 540 cagccgaagg tgtttcactg ggacaaggcc ccgcgttacc tgcccggggc gggccgctcg 600 aaanggcgaa ttccaagcaa cactgggcgg gccgtttacn nagtgggatt cggngctcgg 660 gtancaaggc ttgggggtaa tcaaggggca atagccggtt ttcccngggg tgaaaaatgg 720 tnttccgngc acaantccca nacaancatt ccgaagccgg gaancntnaa agtgttaaaa 780 ncctgggggt ngcccaaatg angtggngct naactcccat ttaaattngc gnttgcgccc 840 nannggccng cctttccaat tncggggaaa cctgttncgt gccaagtcgg cantaaagaa 900 atcncggcna antccccggg gnaaagggcg ggnttgccgt nttggggggc gncttccggn 960 tttcccgggc caaagggann ng 982 35 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 35 cttggcccgc cctcggatcc ctagtaacgg ccgccagtgt gctggaattc gcccttccat 60 cctaatacga ctcactatag ggctcgagcg gccgcccggg caggtataaa atttaaaaaa 120 tttaaaaaaa aagatttgca aaatgtaagt gtagatcatt tgaacaagca aaattaaagt 180 acccactggg ggaaatgtgt ctgaatctta ctcttctgga tctgcaggat tagggcttgg 240 aagtatgtca aagatgcagg gagtgtcaaa gtttaggaag attgtagagc tgagagcaag 300 aagcagaaat gagtgagtca aagaagggag tcctaataca tcaccagatc taggagggga 360 gaggagacag acagaagaaa acaccagagg caagaactgt agaaggccag gtttctgaga 420 atgaattgag cggggtgtcc tgagcagttt ggaaaaggag tttttgatgg tatggtgtag 480 gtgagggctg gctgcatagg aaggactgag gttggagcgg acatcgggaa agctgagggg 540 cagtgaggtt tactacatgg gaaaaggact cttgaaacga gaatcagtgt tgatgtcagg 600 gtgaactttg tgggtacatt acttggtgtt aacattggtg gcagtggtaa gccccttttc 660 agaaagcaac ttgcttgtaa gtcanggtgt ccggtccaac ctttaactag tgaaaaggta 720 gtaaccaatg gtaaaccagg agaatgattg gttnaaccct atctgnggac acttaaatgc 780 cactggttta aaaatggnaa tcacgagttt tgtancaacc ggggnaatat atttaccgga 840 acctttantg ggnnaaagcc ggncnccnaa ggntttttat tncttcnggt tttaacctta 900 acaggtncaa tttataatgc cgggccattt aacaggtcat ttttaacccg gtcnnttttt 960 acccnggtta aaaaanntnt atgcctttag gncaaaanct ttttnngggg gnttnttgtt 1020 nang 1024 36 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 36 taccgcctcg natccctagt aacggccgcc agtgtgctgg aattcgccct tccatcctaa 60 tacgactcac tatagggctc gagcggccgc ccggggcagg tagcaaatgt tgtggcattc 120 ctcctcctcc tcaagtcttt acccgaaact acttcccaag agaggttgct cttcccaaag 180 aatcacctgc cctgggacca tatggggcta ggctgagggt caggagccaa gagcctggtc 240 ccaactctgt ctgtggctta ctgtgagacc ctaggcaagt tgcttaccct ctctggggct 300 caaattcttc ctctttgaaa taggaataat aacttcatca ctagaattct tcacctggtt 360 gttgtgaagt taatcagaat aaatgtggag ataatacatg aatgagcgta cagaatatta 420 tttggctgtt ctgtggcatc gatataggtc atgatagtga caatagtgtc tgtcattgta 480 ttccacacca cttcttccct cagctaaagc aggaaaagaa aggaggtaag tctctctgtg 540 ttttttcttc ctttccccaa gcccactttg ttaccttcct tggttgctgg atgagaaatt 600 agtcagaggg tcagagagga cctcaacttc atatgcttta aatagagcat atgcaatttt 660 aaaccatcct cttaaccaat ttttcttttc ttttcagttt ttccccagtt atacttccac 720 atgatacacc agagaaggaa gatcctttct catactgaag aacacaagaa atttgaatag 780 ttcctgcttt ctgnaccttc caccaaaaca aacttttcaa tgatccaaaa aactggcttt 840 gnactgggga gtcacggaat gggccggctt ccangganca tggcggnngg gcctttgcgg 900 ngtcgggcct gtggtggcgg cggaaaggna accgggggca tggnttnccg agcctggtct 960 tgccccccng ggncatggtg tggaggcaaa gaancctgaa gtccccacng gcccccggga 1020 agna 1024 37 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 37 cttggcaccg cnctcggatc cctagtaacg gccgccagtg tgctggaatt cgcccttcca 60 tcctaatacg actcactata gggctcgagc ggccgcccgg gcaggtgaat tcagcggccg 120 cttttttttt tttttttttt tttttttttt acagggcggc tttttgtttt atttctgctt 180 ttttcccttt ttcttaaaaa aattaaataa agttctcatt atttccccaa tatacatcaa 240 atgagttttc atgcaaagca gcagtcacag aggcagaact gtccccagct cgtgcctntc 300 ggcttgaaga accaccttnt cccggccccg ggttctctgg ngttctcact gaggatggac 360 gacgcccact gtctntccca gctggaactg gctatgacga aacttggctg gcgtagggag 420 aggagtcctc ccctntcccc aggatggggt ctcaggggac agcaagctct ggggcctgat 480 ccccatcact tgnccttcca tctgagactc ccagtgtgac agcttggaca ggtccctctt 540 cccaggaatg cgaggctcct cctctcagct ctcaatggac atggcattaa tgagctgctc 600 caccttataa gccagccgnt gccgccgtgc ctgctcatcc tgctctaggg ccccgatgag 660 ctcctcacta tacttgctga cataggagta gatctcattg ggggcactca acatgttgaa 720 actccacggn gtgcaggcgg gactgctcgg cgagggtagg cattcatggc ctggtcactg 780 gatggctggg aaccttggcc aaggctgcgg nagnatcttt tccccccagc tnttggnaac 840 ttggggaagg cccttgggca taaaaagcaa cttggttgga anggggaggn ctttgcccaa 900 cccgggggct ttggacgttg gaacaagagt nccttgaagg gtttgggncc cccncaaaaa 960 ngcangcntc cgggaaagcc gcccttgggg gtgncaaaac cccnaactgg ggggttnttn 1020 aanc 1024 38 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 38 taccgccctc gcatccctag taacggccgc cagtgtgctg gaattcgccc ttccatccta 60 atacgactca ctatagggct cggcggccgc ccgggcaggt gccgcttttt tttttttttt 120 tttttttttt tttttgcttc acaactgttt attttaagct gaaacttcaa tattcattga 180 ttacctataa taatagttac tcataaatgt agttaataat taaatataaa aattattatt 240 tttacattta tataaatctc tgaaaaatac caagttttga gagatagagc aagaaattgc 300 ttanaaaatt gcaggaagcc tgaanaatct cagcatcagt caaagcaggt ncaacaaaaa 360 acaattttag acattcattt tttgctttaa gagtgcttaa aataaatgat cacagaatga 420 ataactgatg tatggcaaaa atgagtttaa aactatgtaa gctccaaggc cccaatgtgt 480 ataagaattc tttggaagga ttttgaagga ctgtaaatgt tgcaaataaa agtaaaaact 540 agtagttagg caatgngttt taaactatag ngtcacctac tgntcttctg gtgcctaact 600 gnattcttca acatcttctt ttcccttttg attagaaatc ctggtctacc tcaaaggttt 660 tgcattgntt tctagggaca tcagcaaact ggtagaccat atgagaaaca gaaataaaca 720 gtaatattat ctttagaaat taagcattat gtacncagtg agaaatggat tgacttgata 780 gaccttaaac ccctttcttc ctttcacacc ctttntagna ccacctaang gtatccggat 840 tggggatggg gccccnctnt ggtaatcccc ctnnagtcag gacaggggcc cctaagggcc 900 caattttntt tcgaattaga gaaatncccc attttttggg gggttggcaa gtnttanccc 960 anggcttgca aaggcttntt tttgaagana cncccaaacc cggggncttn tttttcngga 1020 atca 1024 39 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 39 tcgcccgagc agnangcncn agcggncnnc agtgtgatgg ttatngtgnn gnnttcgcnc 60 tnccatncta atnctactca ctatagggnn cntgngncnc nnggcnagtn ntnacnnntn 120 annggtgtaa ctgatatcat ntcncnnana ccatggttac atnnanntag gtctcnnang 180 nataccangc tntgagagnt ngaccnggaa ntcgnttnga aannttgngc gangccngat 240 caatatccnc atcngncaca gcggntccgc aagctgacaa tnctgnanat tnattnttgg 300 tttannganc nnttacangn atggnncccn gagatgcatg nnggagtatg gcaaagatgn 360 ntgtaaaact atgtaagctc naaggcccca atgtgnataa cagttcntgg nanggantnt 420 ganggantgt aagngntnaa nntnaangnn anannnaaga ggtangncat gagcccnaaa 480 ctgtagnnnt anctacagng cttanggcgc ctacctggga caggcnacgn cttcattaac 540 cttttgatta gaannacggg ggtaacncac nggttnngca tggtccagta ggngcattgn 600 ccngcngggc aaccatatgc tgngcncaaa taaacggtgc ttttanctca nnagattaaa 660 gctttttggc cacaggggna aaagnatggc ttganaggcc ttaaaccccc gtactcngtn 720 cacccctttn gagaaccncc taacgggatc tggaaatgng atggccccct nttgggaaac 780 nccctanaag anacctcngg ngaccccttg nggcccattt tgangtttag nacngcaatt 840 tncccatttt tgnggttttt gccaacccta agncatnggc tggcaatgga ntgnnttttc 900 caatagaanc aaaccccggn tnttttttgg ggggnatcag ggttaagggn nttggcaaaa 960 nnaaannggc ncnnggnaaa aatttttccc nggtntatcn aaanncccca aagcttttng 1020 caan 1024 40 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 40 nggacgcatg ctcgagcggc cgccagngng atggatntng tgcagaantc gccctttcat 60 gcctatgatc ccngcacttg gngaggccga ggatctcctc tctgggggat cacttgaggg 120 caggagttaa gagaccatcc tggccaccat gatgaaaccc tgtcnctact nnacatacag 180 gaagnagctg gncgngntgg catactctta caatcccagc tacttggnag gntgangcag 240 ganaatcact ngnacctang aagcagaggn tgcatntgnn ccaanancac accactatac 300 tntagcctgn acgacagagg tgntgataan agcnggaccc ctgactatat ncaggntttt 360 ctgacntnna nnancncatc taaatnctac gccgtntgag gtcgcntagg ttangtagnn 420 natnctnatt tatgaccaat atgntgtnan acggcntnnt gntnaaaant tntacagnan 480 ggcngnctac nttncttata atgnggaaaa cggtgnctga natncangtg nnnnngtccn 540 nttnntggna agaggnttng aaanncanca gtgcaccttn tgaactctac nagnagcttn 600 tgaagctaac naagcnttaa natnagatgg cntgntagga ctgtacnngc anggaaagat 660 tcacaaaact ggacattctt naccgagata ngntcttgct ttaccgggga ggacnnntcc 720 aaggntgtnt naagagggac agtcagctta gtnntgctng ggtagagaaa accangactt 780 natntgtgag cttgatnggc agaacctggn nanccttgga agagcntnga ttgnccngat 840 ccctgaaagg gcnnncttna ccctatcggg gaccttnnna acctcttang tggcacgcaa 900 ggcacnaacc nggcncnttt caagaatcnc nggaatcnag gcccctttct tgggntnanc 960 cngnnnnncc cgttnagncc cncgggnaaa anntcttggg nntttccaat cccngnggnn 1020 nttt 1024 41 1004 DNA Homo Sapien misc_feature (1)...(1004) n = A,T,C or G 41 ggtnnnntta atcatcgccn gcttggtacc gagctcggat ccctagtaac ggccgccagt 60 gtgctggaat tcgcccttag cggccgcccg ggcaggtact tcccaccact ggaaatgtta 120 gcataaaaga acttggagag gaaaaaagta ttaacaaaac tgcagtctgc actctttaaa 180 cctgtttaag gctcttcatc ctggttagca aaaggtgtga atgtaatgtg atggaattta 240 aaagttttat gagaccaggc acagtggctc acgactgtaa ttccagcagt ttaggaagcc 300 gaagtgtgca gatcacctga ggtccggaga ccagcctggc caacatggtg aaaccctgtc 360 tctactagaa atacaaaaat tagccaggtg tggtggcggg cgcctgtaat cccaactact 420 caggaggctg aggctagaga atcacttgaa cccagcaggc ggaggttgcg gtgagtcgag 480 atcacgccat tgcactccag cctgtgcgac aagagcgaaa ctctgtctca aaaagatttt 540 ataagaaagc agagcttttc cttgaagctc ttttgaagtg gtagcttaat tagtattttg 600 ntgaaaatac tttaaagatg cctagtgaaa agcctactaa agtgctgtga aaaatggggt 660 ttanaacatt ttattttcan gctttatggc ctattttcca ttgnggcaag tgcaaaacta 720 ccctggccca aangaagggc agagaacata attacctctt anggcacatt tcattctttg 780 cagctttgct taatccagtn gctaagttct ttacctnaac cctgnaggna ttgaacntta 840 ttnccatttn ngnaaaaggg tcaccctntt nnnacaatnt tncannanct ttttnggaag 900 ttanccnttg gccttaaaan ttnaaaantc cntntggnnt tccctttatn ccccnnangg 960 gnnnantang gnntggattt ttaanggncc ttggccngaa cccc 1004 42 1020 DNA Homo Sapien misc_feature (1)...(1020) n = A,T,C or G 42 nnnnnnnnnn nnnnngattg ggccctctag atgcatgctc gagcggccgc cagtgtgatg 60 gatatctgca gaattcgccc ttagcgtggt cgcggccgag gtacctttga taattcctag 120 acctctattt tcattctgtg tattaatgtg aataacagat ggatatttta atatttaagg 180 cagatggtaa actttcctat aggtcttgtg agacttcgtc ttataggctg aacaccattc 240 acaaaatgta ataatgcttc attccttcag gttgaggtaa agaacttgag caactggatt 300 agcaaagctg caaagaatga aatgtggcct aagatgtaat tatgttctct gcccttcctt 360 tgggccaggg tagttttgca cttgacacaa tggaaaatag gccataaagc ctgaaaataa 420 aatgttctaa accccaatct cacagcactt tagtaggctt ttcactaggc atctttaaag 480 tattttcaac aaaatactaa ttaagctacc acttcaaaag agcttcaagg aaaagctctg 540 ctttcttata aaatcttttt gagacagagt ttcgctcttg tcgcacaggc tggagtgcaa 600 tggcgtgatc tcgactcacc gcaacctccg cctgctgggt tcaagtgatt ctctagcctc 660 agccttctgg agtaagttng gaatacaggc gccccgncaa cacacctggc taaattttgn 720 atttctagta naanaccagg ttttnancat gttggncaag gctggtcttc cggaaccttn 780 angtgatctg gacacctttg gntttcctaa actgggtgga aattancagc gggaaccnct 840 ggggcctggc tcattaaacc tttaaaatnc cttnccattc anttcncacc ttttggtaac 900 cccgnatgaa aacccttnaa ccgggtttta agnangcnna nnngggnnat ttgtaaaact 960 ttttccccnt tccaagtcnt ttaagccaan nntttnccng gnnnngggan ccctnccggc 1020 43 1020 DNA Homo Sapien misc_feature (1)...(1020) n = A,T,C or G 43 ggagnnnntt aaacgccagc ttggtaccga gctcggatcc ctagtaacgg ccgccagtgt 60 gctggaattc gcccttagcg tggtcgcggc cgaggtactt tttactgctt tgtcttcaag 120 gcctagtgta ataattaaca tctagtatgt gtttgatgga tagccaattt ttgcttcatt 180 ggtatgttgt taccacagtc attggtagag tcaatatatg aatgaagaaa gtataacaaa 240 tttgccctct agtagagtac tttttttttt tttttttttt ttttgttttt tttttttttt 300 tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt 360 tttttttttt ngnnnttttn ncnttttttn aannaaaaan cggcccnann accnnccnnc 420 nnnttttttt nncnggccnn ccnggnttng gggnngggnn cnttnngggc cnnnnggncn 480 cttttttccn naagggtttt ggggttttng gggnaaantt tnggnncnan nnnggcccna 540 aaaaanttnn gnccnanaan cgcnntttcc nannnnttnn cnttggggcc caaaaanttn 600 cgnaaccccn tgggcnnaaa gggcnttgnt ttttttgggg nncccnaaac canggggggg 660 cnnaaaaaat gncccttgaa ntttttaaaa aaccctntgg naaaancccc nngggttccc 720 ccnnnnnccc ttanttttnn acanaanggn nnaaangggg ncccnnnaaa naccnttngg 780 ggccnttttt tnacaaattt ggggntttnn aaaggggttt tnnggggggc cctntatncc 840 ccnaaaaang aaagggnnnc cccccccnnn nnnnnnnncc cnaanccccc ggnnnttttn 900 ccnggggggg cccnnnaaaa gggggnaant ttnggnaaan nccnnnnncn ggggggnccn 960 ttnaaanntc nntttnanng gggcccnnnn nnccccnnnn annggggggn nnaaaaaccn 1020 44 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 44 nnngnnnnnn nngattgggc cctctagatg catgctcgag cggccgccag tgtgatggat 60 atctgcagaa ttcgcccttt cgagcggccg cccgggcagg tacgcggggc tcggcgctgc 120 ctacggaggt ggcagccatc tccttctcgg catcatggcc gccctcagac cccttgtgaa 180 gcccaagatc gtcaaaaaga gaaccaagaa gttcatccgg caccagtcag accgatatgt 240 caaaattaag cgtaactggc ggaaacccag aggcattgac aacagggttc gtagaagatt 300 caagggccag atcttgatgc ccaacattgg ttatggaagc aacaaaaaaa acaaagcaca 360 tgctgcccag tggcttccgg aagttcctgg tccacaacgt caaggagctg gaagtgctgc 420 tgatgtgcaa caaatcttac tgtgccgaga tcgctcacaa tgtttcctcc aagaaccgca 480 aagccatcgt ggaaagagct gcccaactgg ccatcagagt caccaacccc aatgccaggc 540 tgcgcagtga agaaaatgag taggcagctc atgtgcacgt tttctgttta aataaatgta 600 aaaactgcaa aaaaaaaann nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 660 nnnnnnnnnn nnnnnnnnnn nnnnnannna aancccnnnn aaaanannnn nnnnaaaaag 720 gcttntttta angggcaaat tgggaaacct ttttnattca aaaatggctt ttnccangga 780 ctggggacca nnttncccng gggnccaaaa ttgggntttc ctttaanccc nttncnnaan 840 gggaattttt ncccttgggc cttgaaaaac naagcnnnna aaaagnccct tgggnnggaa 900 acccctttng ggggaatttc cncnccnttg ggggggcnnt ntnnnnnggg acccnanttg 960 gncccaantt ttggggaaaa nnngggnnaa aaagggnnnc cctgggggaa aatgttnccc 1020 ccca 1024 45 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 45 ggagnnnntn aatcatacgc cagcttggta ccgagctcgg atccctagta acggccgcca 60 gtgtgctgga attcgccctt tcgagcggcc gcccgggcag gtacggcgca ttttgtgcac 120 acaaaatgtg cgcacacaca cacacacaca cacacagaca ctcctgcaca tggcctgtta 180 aagaactaca agggaggtgg gacgcgggaa agtgtatggt gtgggtttgc atcgtctcat 240 cattgattct tctcatattt ttctctgatt agagaaacta aagagaattt tgtgagaaag 300 gcttgaaagt taatgagtta cttctaccaa agtgattaca agcagaaatc ctcagatgct 360 gtagagatgc tgacccacac atccttagct caaggaagcc cctcgcatta gtcaccttca 420 gccatcagca gcctccacca ttaaccccag tgtgctgtat aaaaaatact ttctacatgt 480 gcccaaattt gaaaagttag gaagcactga tttcaaagca aatcattcac atttgaactg 540 tcttcagtgt acctcggccg cgaccacgct aagggcgaat tctgcagata tccatcacac 600 tggcggccgc tcgagcatgc atctagaggg cccaattcgc cctatagtga gtcgtattac 660 aattcacttg ccgtcggttt tacaacgtcg tgactgggaa aacccctgcg ttacccaact 720 taatcgncnt ggagcacatt ccccntttgg ccnactggcg taattaacca aaaaggnccg 780 gaccgaatcg gccntttcca acaagttggg ccaacctgaa tnggcnaaan ggcccccccc 840 tgtaaccggn gccattaaac ccccgncggg nnnntngggg tacccccaac ggggaccggt 900 taacttggcc anggccttaa ggcccggtcc ttttggtttn ttncctttcn tttttngccc 960 ntttnccngg nttttcccgn aaagntntaa aaaggggggg tccccnttta ggggtcccaa 1020 taaa 1024 46 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 46 nnngnnnnnn nnnnnnngaa ttgggccctc tagatgcatg ctcgagcggc cgccagtgtg 60 atggatatct gcagaattcg cccttagcgt ggtcgcggcc gaggtacact gaagacagtt 120 caaatgtgaa tgatttgctt tgaaatcagt gcttcctaac ttttcaaatt tgggcacatg 180 tagaaagtat tttttataca gcacactggg gttaatggtg gaggctgctg atggctgaag 240 gtgactaatg cgaggggctt ccttgagcta aggatgtgtg ggtcagcatc tctacagcat 300 ctgaggattt ctgcttgtaa tcactttggt agaagtaact cattaacttt caagcctttc 360 tcacaaaatt ctctttagtt tctctaatca gagaaaaata tgagaagaat caatgatgag 420 acgatgcaaa cccacaccat acactttccc gcgtcccacc tcccttgtag ttctttaaca 480 ggccatgtgc aggagtgtct gtgtgtgtgt gtgtgtgtgt gtgcgcacat tttgtgtgca 540 caaaatgcgc cgtacctgcc cgggcggccg ctcgaaaggg cgaattccag cacactggcg 600 gncgttacta agtggatccc gagctcggta ccaagcttgg cgtaatcatg gncatagctg 660 nttcctgtgt gaaattggta tccgctcaca attccacaca acatacgagc ccggaagccn 720 taagtgtaaa agccctgggg tgcctnatga gtgagctaac tccattaaat tgcgttgccg 780 ctcactggcc ggtttcagtc cggnaaanct gcggncnact gcantaatga atcggncaac 840 gcccccggga aaaaagcggt tgcgaattgg gccctntttc cctttcttgg ttaatggact 900 ccntnngnct tnggccnttc ggnttnggnn naacgggatt aanttnnntt naaagggggg 960 naanacgggt ttncccnana aatcnggggn aaacccccng gaaanaaacn ttggncccaa 1020 nggc 1024 47 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 47 ggngnnnnnn aaacgccagc ttggtaccga gctcggatcc ctagtaacgg ccgccagtgt 60 gctggaattc gcccttagcg tggtcgcggc cgaggtgcat ctgaacattg ccaagcccta 120 ggacattccg tagagcttgg ggattctgga ccaattggtt cagacaggac acgaaatgcc 180 tgtttgatgg gttctgcaat taaacaccca actactctct tttcatcaga tataaaaaga 240 aaagttttta ttttgtttgg acatttagga acaacttgct ggaagcccaa ttcattatca 300 acaagttctt ggacatcttc tacctttttg atagcaaagc ttggatcatg tggcagaacc 360 aacacgattt tcccatccca aaactctgct actacacgtt ctttcttcca acccacatat 420 ttgattcctt ccagaaacct gtggtgatgc tgtacctgcc cgggcggcaa gggcgaattc 480 tgcagatatc catcacactg gcggccgctc gagcatgcat ctagagggcc caattcgccc 540 tatagtgagt cgtattacaa ttcactggcc gtcgttttac aacgtcgtga ctgggaaaac 600 cctggccgtt acccaactta atcgccttgc agcacatccc cctttcgcca gctggcgtaa 660 taagcgaaga ggcccgnacc gatcgccctt tccaacagtt gccgcagcct gaatggcgaa 720 tggacgcccc ctgtanccgg cgcattaaac cgccggcggg tnnttggggt accccncacg 780 gggaccggta cactttgnca agggccctaa cggcccggtc cntttcgctt tcttnccttt 840 cntttnttgg ccacgttngn ccgggttttc cccgtnaagc ttttaaaatn gggggcttcc 900 cnttttaggg gttccnaatt aanggcttta cgggaccctt gaccccnaaa aaactttnnn 960 tttnnggggg gnggggntnc ccntaggggg ccattgnccc ttgnnaaaaa anggtttttn 1020 nncc 1024 48 1017 DNA Homo Sapien misc_feature (1)...(1017) n = A,T,C or G 48 gnnnnnnnga ntgggccctc tagatgcatg ctcgagcggc cgccagtgtg atggatatct 60 gcagaattcg cccttgccgc ccgggcaggt acagcatcac cacaggtttc tggaaggaat 120 caaatatgtg ggttggaaga aagaacgtgt agtagcagag ttttgggatg ggaaaatcgt 180 gttggttctg ccacatgatc caagctttgc tatcaaaaag gtagaagatg tccaagaact 240 tgttgataat gaattgggct tccagcaagt tgttcctaaa tgtccaaaca aaataaaaac 300 ttttcttttt atatctgatg aaaagagagt agttgggtgt ttaattgcag aacccatcaa 360 acaggcattt cgtgtcctgt ctgaaccaat tggtccagaa tccccaagct ctacggaatg 420 tcctagggct tggcaatgtt cagatgcacc tcggccgcga ccacgctaag ggcgaattcc 480 agcacactgg cggccgttac tagtggatcc gagctcggta ccaagcttgg cgtaatcatg 540 gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc 600 ccggaagcat aaagtgtaaa gccctggggt gcctaatgag tgagctaact cacattaant 660 gcgttgcgct cactggccgc tttccagtcn ggaaacctgt cgtgccagct gcattaatga 720 atcggncaac gcgccgggga aaaagcggtt gcgtaattgg gcgctctttc cgctttcttg 780 nttacttgac tccttgggct tcggccgttc ggntgcggnn aacggnattc aacttactca 840 aaaggcggna atacggtatt cccngnaatc nggggataac ccccggaaan aactttgacc 900 naaaggcccc caaaaggccc ngaacccgna aaaaagggcn cgnnnnnnnn ggggtttcct 960 aaggttccgg ccccctggnn aggtttccca aaaatngnnn cctttnannn nnnnngg 1017 49 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 49 ggngnnnnnn anatnaaacg ccagcttggt accgagctcg gatccctagt aacggccgcc 60 agtgtgctgg aattcgccct tgagctggcc gcccgggcag gtactgaaat tactctgaat 120 tcagaaatgt aagtatatgc agctaggtca taaagacact gctttagaga agacatgtat 180 tagtggaatg gaacaggtaa catctttgag aagtcaatga gttctgcatg cagggatttc 240 accatcggaa tgatggcaag aatgatgcct gcctgtgtgc ttctcagagg acgtataaag 300 ccactgagga tgagtgctac agtgcttgtg aattgtgggg ccacagacat ttaagttggc 360 attgcttttc tcctcctctg cttaatccac ctttataaat atggcagatg gcttaagaca 420 ggcatcatca gcatctctgg agatgtgggc tcagagggca agtgggggcc gtgggggttt 480 ccactagagg gagggaagtt tctgtttccc atgtgttagt tgtagttgtc tttgtgcttc 540 accagaaaag aggtagagtg cgcaccttca cactaagagc ccgaaattgt gggtcagtac 600 tttttttttt ttnnnttttt tggtnntttt tnnnnnnnnn nnnnntnnnn ngnnnnnnnt 660 tnnnttnnnn ngnnnnnnnn nnnnnnnnnn tttnntnngg nnnncncttn nnnnnnaann 720 nngnnnannn ncnnnnnnnn tngnnnnnnn nnnnncnttn ngggnnnang ncccnannnn 780 nccnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnccnannn nnnnnnntnn 840 nnnaanncnn tnnnnnnnnn nnnggnnnnn nnnnttnnan nnnnnnnnnn nngnnnaann 900 nnnnnnnnnn nnnnnnnnna annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 960 nnnnnnannn nnnanngggn nnnncccnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnntt 1020 nngg 1024 50 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 50 ggagnnnntn nntncngant gggccctcta gatgcatgct cgagcggccg ccagtgtgat 60 ggatatctgc agaattcgcc cttagcgtgg tcgcggccga ggtacactga cttgagacca 120 gttgaataaa agtgcacacc ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 180 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 240 aaaaanaana ntaaaaaaaa tttnaaggta aagntnncnn ntnaaaatct tttagggnna 300 tccntatann nnttttcgnn tntttnnngg ntngncctct nntnccnnnt tttttnggna 360 ancccnaann cccngnctta ccnnatgngn cananttaaa anggtncntt nttnngngga 420 nctcannncc cccgccnttt tnntnngggg ggnttnncca nnggnggnna aatgcncngc 480 tnatnaanan gggnttnntc cnaaatnngn naanccctga ggnggnaanc ntnntggnct 540 tnntncngat tnngnnaccc ccncnngcag anntcnttgn nnccttantn ccgggggnta 600 nacccttcct ttaaaancnc nntgntntna aaaannnttt ncctgancna tcgggntaaa 660 ncnnnttttt tgaaaaccnn ggctttttnn aanangctcc gntnggcnaa ctttggggaa 720 naaggnnttt tttaaggcct tgctttttag ggccanccta anggngannn ncngttgnct 780 tgnnngatgg tttttagggn ttcccgggtg ggaccnttnt tggggggaaa ttttggnccn 840 aggggntccc ctnnaagaaa tccnnnttcc nggncncnaa ttnccnnaaa aattnngggn 900 ccnaaanntt tnattgggaa ggncctttgg ttgccccnnt aaanggnccn naaaccttta 960 aanggggggn gcntttaatg gcncctttcn ggncccnaaa aaanggggnc cccccnnttt 1020 nagg 1024 51 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 51 gngnnnnntt aactcccgct tggtaccgag ctcggatccc tagtaacggc cgccagtgtg 60 ctggaattcg cccttagcgt ggtcgcggcc gaggtacttt ttttttcttt tctttctttt 120 tttttttttt tttaattttt gagatggagt tttgctcttg ttgcccacgc tggagtgcaa 180 tggcgcaatc ttggctcatt gcaacctcca cctcccggat tcaagcgatc cttctgcctt 240 agcttcccaa gtagctggga ttatagacgt gtgccaccat tcccagctga tttttgtatt 300 tttagtagag atggggtttc accacgttgg ccaggctagt ctcgaactcc cgacctcatg 360 tgatcctccc accgcagcct cccaaagtgc tgggattaca ggcgtgagcc accatacccg 420 gttgattgta gacttttgat tggtatttac aaggacccat gagaggcaac aaagagaagt 480 tgtcaagaga acagaccctg agaccaatag tttggctcaa gctctggctc cctaacttcc 540 taccagtttg accttgggca agttacctaa catctttgtg cctccatttt ctatttgtaa 600 aaggaaacta atagtagtgc ctactttata atagagttat tacaaatatt aaatgagtta 660 atatttgtaa agtaattaga aaaatgcctg gcacttcaaa agcagccttc atttattctt 720 tggaaataat tttaaatgaa ttcaagggtt atatgtagct tttaggcata tatncctaaa 780 tggcactgta aaactgcana aatatccgat ctttaaaaat ttttgggtaa atttatcata 840 atatggnaac caaatcccat ttaatggctt ttaggggtan ccgatnaaaa ccngaagttt 900 gcagtttaag ccncttatgg aangggaccc gaaattccaa ggancccann gggaaaaaac 960 cccnngagga atnttggccg ntttaantta aancctttgg gtnntttaag nncctaaaaa 1020 nttt 1024 52 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 52 gngnnnnnnt tnngnttcng antgggccct ctagatgcat gctcgagcgg ccgccagtgt 60 gatggatatc tgcagaattc gcccttcgag cggccgcccg ggcaggtact tcaaaactat 120 tcataagcaa aaatcagtgt caaaaatatt tagtaactta aaaaaaacaa aaagtataag 180 tagagacgga caagaactcc tcctgctttc tcccactggg ctcatcgtat ttctgttcca 240 ttacataaga gactaaaact gacaaactct gttttatcgc taacacctaa aagcaataaa 300 tgtgatttgt taccatatta tgataaaatt taaccaaaaa attttaaaga tcggatattc 360 tgcagtttac agtgacattt atgtatatat gcctaaaagc tacatataaa ccttgaattc 420 atttaaaatt atttccaaag aataaatgaa ggctgctttt gaagtgccag gcatttttct 480 aattacttta caaatattaa ctcatttaat atttgtaata actctattat aaagtaggca 540 ctactattag tttcctttta caaatagaaa atggaggcac aaagatgtta ggtaacttgc 600 ccaaggtcaa actggtagga agttagggag ccagagcttg agccaaacta ttggtctcag 660 gggtctgttc tcttgacaac ttctctttgn tgcctctcat gggtccttgt aaataccaat 720 caaaagtcta caatcaaacc gggtatgggg ctcacgcctg taatcccagc actttgggga 780 ggctgcggtg gggaggatcc ccatganggt ncggagttcg agactagcct gggccaacgt 840 ggnggaaacc ccatctntac taaaaattcc aaaatcanct ggggaaggng ggcacacgtc 900 tataatccca cttccttggg aagcttaagg ncnnaaggac gcttggaaac ccggaanggn 960 gnggttcaat ggancccaaa atgngccatt ggnctttcnc gngggccaac angagccaaa 1020 ntcc 1024 53 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 53 gggnnnnnnn tnncttaacg cccgnttggt accgagctcg gatccctagt aacggccgcc 60 agtgtgctgg aattcgccct tagcgtggtc gcggccgagg tacattactt ggtgttaaca 120 ttgttggcag tggtagcccc ttttcagaaa gcaacttgct gtaagtcagg gtgtccgttc 180 caaccttcag ctagtgaaaa ggtagtaaca aatggtaaac aagagaatga ttgtttaaac 240 ctatctgtgg acacttaatg caactgttta aaaatgataa tcacgagtta tgtagcaacg 300 tggaaatata tttacagaac attaagtgga gaaagcagga cacgaaagta tatttatact 360 acagttataa ctcaacagtt catttatatg ctgttcattt aacagttcat ttaaacagtt 420 cattataact gtttaaaaat atatatgctt atagtcaaaa gctgttgtgg tgttgttgtt 480 gtaggcttat agttgagcat tattttctta aatttcttga atgttcttta tggtagtgtt 540 actaaaaagt ttatgatcac attttcattg tgaacataat ttgaactcat tatcacacac 600 ttggaaaata cagaaaagtg gaggaaaaaa aatcatatcc ccaccatcca aagacatata 660 ctctcctctt atcttgntca ttcttggttc tgngcacagg tttatgatta taactgngtc 720 aaaatgtata ttcaaaatag ctggtacatt acctttgngg nattatgggt aaatctttca 780 ctttaatttt ttcaaaggtc cctatnataa tggcccggat aaccgnggga tttaaggggg 840 ctcccatggn gggcataatn catacccnga ggaaaaattn naaaattaag gnaantattt 900 ttaaaaaatt ncctatattt cccaaaacct aacaactact ggtaaaaatn ttggaccggn 960 tccccctatt ntnggttaan ggcccaccct ttgggnaaaa ccggggtnaa aaattggggc 1020 ctaa 1024 54 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 54 ggagnnnnnn ttnngtttgg gccctctaga tgcatgctcg agcggccgcc agtgtgatgg 60 atatctgcag aattcgccct ttcgagcggc cgcccgggca ggtacttttt tttttttttt 120 tttttttttt ttacatttat gcatacttat cactaacacc ctaataatca cagactagtg 180 cacagatcaa gatgttaaca gttaattgtt gttgggtgtt gggaatatgt gtgaattttc 240 tttactgaat ttccaaagtt ttgtatgagt atgtattata tttgtaatgg aaaatacata 300 cataaaattt attaccaaaa caccaaagat tatttaagga atttgagaca aaatatttaa 360 ccaaattccc acaatgacaa cactatttta gttattttcc acatcttttc atttaagact 420 ttatgcacac atatttaaca ctgttatcac aagcgtgtgc actgaaacaa gatagaggaa 480 acagatcaag atgttagcag tagttgttag gtgttgggaa tataggtaat tttttaaaat 540 aatttacttt attttctaat ttttcctctg ggtatgtatt atgcacacca atggagacac 600 acataataca ctgttatcag gacattatta tagggaacat ttgaaaaaat taaagtgaaa 660 gtatttaacc ataattccac aaaggtaatg taacagctat tttgaatata cattttgaca 720 cagttataat cataaacctg tgcacagaaa cnagaatgaa cnngattaga ngagagtata 780 tgtctttgga tggtggggat atgaattttt cctncacttt tctggatttt nccagtgtgn 840 gaaaaatgag ttccaaaata tggtcncaat ggnaaatgng ancntnaacc ttttagtanc 900 ccttnccttn aggaacattt caggaaantt tannaaaata anggctcaac ttttaggcct 960 acannancaa ccccncaaaa ggnttttgac tntttanccn tntatatttt taaccggttt 1020 taan 1024 55 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 55 gnngnnnnnn ttaactccag cttggtaccg agctcggatc cctagtaacg gccgccagtg 60 tgctggaatt cgcccttagc ggccgcccgg gcaggtacct cacatgggaa acatgggaag 120 taaaaccacc tgaggagcct cttgatggtg agtcaggctg ttcctcgaag agtaggctgt 180 gactgccaaa ctttgtaggt taaggagtat ttataatgat ctttgaggaa actgcaactg 240 acaattgagg gaaaaaaatg ttagttcatg actgcaaaat acatgacaga atcacaaaaa 300 ctattttaca agtttaaaaa acaaacctga tgctgatgca tggcaggcga accccaaagt 360 ggggcttagc ctgcaagggt tcttggcttc acccaggaaa ggattcaagg gcaagccagt 420 ggtaaggtgg aagaaaacac ctttatcaaa gcaacactgt tacagctcct gtggggtcac 480 agctcagtga ctgctcccag ggttgcccca taggcagggt gccgagagta gcagctgagc 540 ccagttttgc agtcatatgt atacctactt ttaattacat gcagattcag gggtggtttg 600 cgcagaaatt gttaggaaaa gggtggtaac ttttgggtca tcaggtcatt gccgcttaaa 660 gtggtggtaa tgcctgagtt ttgccatggc aatggtaaac tgacaaggca cgctgcttgg 720 tgtgtcttac agaaagctgc ttncgctctg nccttggtta nctagccctc gancntttgg 780 ttgtaaatga accaagagaa gtcaccggcc cttggcgttt tcttcccaga agtacccttg 840 ggccgggaan cacgcttaag ggccaaattc ttgcagatat ccatnacact tggcnggncc 900 gnttcancct tgcattttaa aagggcccaa tttgnccctt taaanggagt cgantaccaa 960 ttnnnntggg ccgcgtttta acaacgtnnn ggacttggga aaaanccctg ggttacccca 1020 antt 1024 56 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 56 gnagnnnnnn ttnngttnca gantgggccc tctagatgca tgctcgagcg gccgccagtg 60 tgatggatat ctgcagaatt cgcccttagc gtggtcgcgg ccgaggtact tctgggagaa 120 aacgccaagg ccgtgactct cttgctcatt tacaaacaaa agatcgaggg ctagctaaac 180 aaggacagag cggaagcagc tttctgtaag acacacccag cagcgtgcct tgtcagttta 240 ccattgccat ggcaaaactc aggcattacc accactttca gcggcaatga cctgatgacc 300 caaaagttac cacccttttc ctaacaattt ctgcgcaaac cacccctgaa tctgcatgta 360 attaaaagta ggtatacata tgactgcaaa actgggctca gctgctactc tcggcaccct 420 gcctatgggg caaccctggg agcagtcact gagctgtgac cccacaggag ctgtaacagt 480 gttgctttga taaaggtgtt ttcttccacc ttaccactgg cttgcccttg aatcctttcc 540 tgggtgaagc caagaaccct tgcaggctaa gccccacttt ggggttcgcc tgccatgcat 600 cagcatcagg tttgnttttt aaacttgtaa aatagttttt gtgattctgt catgtatttt 660 gcagtcatga actaacattt ttttccctca attgcaagtt gcagtttcct tcaaagatca 720 ttataaatac tccntaaccc tacaaagttt ggcaagtcac agnctactct ttgaggaaca 780 agcctgactt accatcaaga agcttccttn anggggntta cnttccatgg tttcccatgg 840 tgaaggancc tgncccgggc ggccgnttaa gggcgaaatt caacacactt gggnggccgn 900 tnnnttaang gatccnaact tggganccaa annnttgggg naaannatgg gnnnnnaact 960 ggnnnccggg ggggaaaatg gtatnccgnt tccaatttcc ccncnanntt tnnaancccg 1020 gaan 1024 57 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 57 gngnnnnntt nantnaacgc cagcttggta ccgagctcgg atccctagta acggccgcca 60 gtgtgctgga attcgccctt agcgtggtcg cggccgaggt actcatcact gacttgaagc 120 ttagtatctg gcttccttaa ggatgtaact ttcatgtaac agattaataa cttatatgaa 180 aaccaacaca accatatgtt tagggctgga aagggccatg acgcctggtc atttttcctg 240 ttttacctta ctcttatgtg tgtcacactt catcaattcc ggaaacagtt tctggagatc 300 tcctcattac ctcttttaca atcacctcac tccagcatgg tgtctgttac ctcttcccac 360 ttgtgacaat gtctagtaag gtccactctc cattctgtgt gatgaccact tattacaacc 420 ctcagaatag gggacagtgg tgtgccccct gcaatacaat ggtttctatc tcctgatact 480 tttattacac ctctagcagg atgtcttgtg atcctcctta ttgatttttc cctcacgatg 540 atgaacaatt atctcccgtt actcacctag cagtatctaa ctgtccctaa cacagcatgt 600 gggaatgccc tcaatacggt ggatgctgnt aactttcttc cttcccctca ggcaatggcg 660 gtgacttaca atgaaccata atggccacat ttcccaactg nattttggaa cctcttctgn 720 ccccttcttt ctagganccc agttaaaaaa aaaaaaccaa aactagcccc aatgnctgtg 780 atgcccatta atcacttacc cagggctgan ccctncatta aanttttgat gggatctctt 840 tggnttccca attggccgtt naacccaagn ctgntggatt cccaanttnc cccattgntt 900 taatgcgggt cccttaanca ncccttggnt actggacctg gccngggngg gcccttttaa 960 aaagggcaaa ttntggagaa aatnccttnc acttgggggg ccnttnnaac atggcntttt 1020 aang 1024 58 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 58 gngnnnnntt nngtttggcc ctctagatgc atgctcgagc ggccgccagt gtgatggata 60 tctgcagaat tcgccctttc gagcggccgc ccgggcaggt acagtagcca agggtgacta 120 aggaaccgca tgaagcaatg tgggaaattg ggaatcagca gacattgggt taacgggaca 180 atggggagcc aagagatacc atcaaaattt aatggagggg tcagacactg tgttagtgat 240 taatgggcat caacagacat tgggctagtt tttgtttttt ttttttaact ggggtcctag 300 aaagaagggg acagaagagg ttccaaaata cagttgggaa atgtggacat tatggttcat 360 tgtaagtcac cgccattgcc tgaggggaag gaagaaagtt aacagcatcc accgtattga 420 gggcattccc acatgctgtg ttagggacag ttagatactg ctaggtgagt aacgggagat 480 aattgttcat catcgtgagg gaaaaatcaa taaggaggat cacaagacat cctgctagag 540 gtgtaataaa agtatcagga gatagaaacc attgtattgc agggggcaca ccactgtccc 600 ctattctgag ggttgtaata agtggtcatc acacagaatg gagagtggac cttactagac 660 attgtcacaa gtgggaagag gtaacagaca ccatgctgga ntgaggtgat tgtaaaagag 720 gtaatgaaga gatcttccag aaactgtttc cggaattgat gantgtgacc cnccttaaga 780 ntaaggtaaa acaggaaaaa tggnccaggc gtnatnggcc cttttcagnc cttaaccttt 840 attggtgggg tggtttcata taagttantt aatctggtnc cctgaaagtt tccttccttt 900 anggaaaccc gantcctaan cctttnaagt ccnnggatga gacccttggn ccgggaaccc 960 cccttaaggg cgaaattccn ncccacttgg gngggccntt nncttaaggg acccaacttg 1020 ggcc 1024 59 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 59 gagnnnnnnt taactcccgc ttggtaccga gctcggatcc ctagtaacgg ccgccagtgt 60 gctggaattc gcccttagcg tggtcgcggc cgaggtacct ggttttcttt caactcttca 120 atttcccatc ttccatcgta tattgaaatt tcctcatcca tgtcatcttt ctttgctttt 180 gataagaccc atccagccaa ccttccacta tcaaaagttt ctgcaaaata tacttctcct 240 ataggttgag gtgtcttata tttaatctct gaggaaagtt cactttcatt aacatcaatt 300 tcttctgaat tttcttcaaa gtcttccgtc tcaacatcat catccataaa ttctgcatta 360 attgagatga acagaagacc caaacataac caaaaggctt ggaaatgcat attgattatc 420 tctcttgcgg cctgttttcg gcagtgacag ctcagatgtc caagtcgttg ccacttggtc 480 cccgcgtctc ttcagaccag tcccccccgc gtacctgccc gggcggccgc tcgaaagggc 540 gaattctgca gatatccatc acactggcgg ccgctcgagc atgcatctag agggcccaat 600 tcgccctata gtgagtcgta ttacaattca ctggccgtcg ttttacaacg tcgtgactgg 660 gaaaaccctg gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg 720 cgtaataacg aaaagcccgc accgatcgcc ctttccacag ttgcgcagct gaatggcgaa 780 atggaccccn ccctgtancg gcgcattaan ccnccngcng gttnntgggg tacccccaac 840 ggggaccggt acactttgnc aagggcctaa cgnccggttc ntttggtttc ttncctttcn 900 ttnttngcac gttngnccgg nttttcccgt naagctttaa aatngggggc ttcccctttt 960 angggtcccn aataaaggtt ttacggganc ttgaaccccc aaaaaacttt gnnttnaggg 1020 ggga 1024 60 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 60 gnnnnnnttn ngttncngaa ttgggccctc tagatgcatg ctcgagcggc cgccagtgtg 60 atggatatct gcagaattcg ccctttcgag cggccgcccg ggcaggtacg cgggggggac 120 tggtctgaag agacgcgggg accaagtggc aacgacttgg acatctgagc tgtcactgcc 180 gaaaacaggc cgcaagagag ataatcaata tgcatttcca agccttttgg ttatgtttgg 240 gtcttctgtt catctcaatt aatgcagaat ttatggatga tgatgttgag acggaagact 300 ttgaagaaaa ttcagaagaa attgatgtta atgaaagtga actttcctca gagattaaat 360 ataagacacc tcaacctata ggagaagtat attttgcaga aacttttgat agtggaaggt 420 tggctggatg ggtcttatca aaagcaaaga aagatgacat ggatgaggaa atttcaatat 480 acgatggaag atgggaaatt gaagagttga aagaaaacca ggtacctcgg ccgcgaccac 540 gctaagggcg aattccagca cactggcggc cgttactagt ggatccgagc tcggtaccaa 600 gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc 660 cacacaacat acgagcccgg aagcataaag tgtaaagccc tggggtgcct aatgagtgag 720 ctaactcaca ttaaatgcgt tgcgctcact ggccgctttc cagtcnggaa accctgtcgt 780 gccagctgca ttaatgaatc ggccaacgcc ccgggggaaa aagcggnttg cgtattgggc 840 gctcttccct ttcttgntta cttgactcgc ttgggcttcg tcgttcggct gcggcnaacg 900 gnatcagctt actcaaangc gggaaatacg gtantcccca gaatccnggg gattaccccn 960 ggaaaagaac ctgtgagccn aanggccccc aaanggcccn gaaccntaaa aaanggcccg 1020 tnnn 1024 61 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 61 gggnnnnnnt tncttacacg cccgcttggt accgagctcg gatccctagt aacggccgcc 60 agtgtgctgg aattcgccct ttcgagcggc cgcccgggca ggtacaaatg gttttatgtc 120 accaattttg ctgcaagaat gggaactgct tttaaatctg taaatagctc ttaacatttg 180 ttgtatgcac tcttttctta ctatggctgt caacacttgt gtagggttta atttctaaat 240 tgttggcatg ttctttttct caggctattc agaagtaaca acatttttca tttcagacat 300 gcaatcacct attaatgatg aaatatttta ccactttggg aatatttaat tagtttagtc 360 atggagaata cttcccacat tttaagattt ttcaaatatc actgtcattt ctattttagc 420 attttatcaa attattgctt ttttatttta taataaggct taagacagat tatagacctc 480 cttaagagat gagtttcttc ttctaaaaat gcatgttgat agaggactat ttaggctaat 540 cggaggaatc attaagaaag aaagttttaa cactgtttat ccctatctgc tttccttgca 600 ctttttctgt gaaaaatatt ttctgtttgc aaaatcttcc ctgagttctg aacccagcac 660 catcagtacc tcggccgcga ccacgctaag ggcgaattct gcagatatcc atcacactgg 720 cggccgctcg agcatgcatc tagagggccc aattcgccct atagtgagtc gtattacaat 780 tcactggccc gcgnttttac aacgtcgtga ctgggaaaac ccctgcgtta cccaacttaa 840 acgcccttgc agcacatccc ccttttgncc aantgcgtaa ttaccaaaaa ggcccgnacc 900 gaacggccnt ttcccaaagg tggcncaacc ctgaaatggc aaatgggccc cccccttgaa 960 ccggngccnt taancccccc nccgggnntt tnggggtccc cccacggnga nccgttaaac 1020 ttgc 1024 62 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 62 gnagnnnnnn ttnngnttgg gccctctaga tgcatgctcg agcggccgcc agtgtgatgg 60 atatctgcag aattcgccct tagcgtggtc gcggccgagg tactgatggt gctgggttca 120 gaactcaggg aagattttgc aaacagaaaa tatttttcac agaaaaagtg caaggaaagc 180 agatagggat aaacagtgtt aaaactttct ttcttaatga ttcctccgat tagcctaaat 240 agtcctctat caacatgcat ttttagaaga agaaactcat ctcttaagga ggtctataat 300 ctgtcttaag ccttattata aaataaaaaa gcaataattt gataaaatgc taaaatagaa 360 atgacagtga tatttgaaaa atcttaaaat gtgggaagta ttctccatga ctaaactaat 420 taaatattcc caaagtggta aaatatttca tcattaatag gtgattgcat gtctgaaatg 480 aaaaatgttg ttacttctga atagcctgag aaaaagaaca tgccaacaat ttagaaatta 540 aaccctacac aagtgttgac agccatagta agaaaagagt gcatacaaca aatgttaaga 600 gctatttaca gatttaaaag cagttcccat tcttgcagca aaattggtga cataaaacca 660 tttgtacctg ccccgggcgg ccgctcgaaa gggcgaattc cagcacactg gccgnccgtt 720 acttagtgga tccgagctcg gtccaagcct tgcgtaaatc atggnccata ntggttcctg 780 nggtgaaatt ggtatcccgg tcacaatttc nccccancat acgaanccgg aagccntnaa 840 gngtaaaanc cctgggtggc ctaatgagtg aactaactca catttaaatg cgtgcgctta 900 ctggcccgtt ttccaatcng ggaaanctgt cgngcccact ggntttaang aatcggccan 960 gcccccnggg gaaaaaagng gttgcnnatt gggccctttt tcggttcctt ggttantgga 1020 atcn 1024 63 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 63 gagnnnnnnt taacncccgc ttggtaccga gctcggatcc ctagtaacgg ccgccagtgt 60 gctggaattc gcccttagcg tggtcgcggc cgaggtacat tgacttcatt actaaagaac 120 aaaaatgttc atttttgtcc cagtaaattg agactgcttg tacttttttt tttttttttt 180 tttttttttt ttattaaaat actgagtttt atttcacatg tatatttttg tctccccacc 240 atttccatgt ctgaccaccg ctactactat gtcctatcat aacattccat acatacttaa 300 aaccaagcaa agggtggagt tccatcttta aaaactaaac ggcattttgg acaacacatt 360 cttggcaata naacctggac aacatttatc aaacacggta gggaaagttc tcactctgca 420 ttataaaaag gacagccaga tatcaactgt tacagaaatg aaataagacg gaaaattttt 480 taacaaattg tttaaactat tttcttaaag agacttcctc cattgccaga natcttgaat 540 agcctcttgg tcagtcatcc ggaagcaatt cttcacataa ttgatgaatt tggcttccac 600 tttgggaaga gaaccacctt tttctatact tgcttgcatt tttgctttaa tgncttctac 660 agaactaggt ccttttggng ttttaggagt tttttcctgn ttcttgaagg attcttggcc 720 ttttganctt ggggttgaaa ganggntttg agtcttttca ttctgaattg acttttgggc 780 atttttggct ggagnatctc ggatagattt cttcactggg gctttttctt nagntttcct 840 catatcaaaa tcntcatcat catcancttt atnaanatcc cctttaatna anatcggnat 900 tnatntttat tnagcngcaa ggtttacttt ttttctgggg gaanctttgt tanccccttt 960 cagggggcaa aaccggtttt ccaaaaatnc ccttaanaat ttnccaaanc cnccnccntt 1020 ttaa 1024 64 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 64 ggagnnnnnn ttnngtttcc gaattgggcc ctctagatgc atgctcgagc ggccgccagt 60 gtgatggata tctgcagaat tcgcccttag cggccgcccg ggcaggtaca gccaacggtt 120 tcccttgggg gctttgaaat aacaccacca gtggtcttaa ggttgaagtg tggttcaggg 180 ccagtgcata ttagtggaca gcacttagta gctgtggagg aagatgcaga gtcagaagat 240 gaagaggagg aggatgtgaa actcttaagt atatctggaa agcggtctgc ccctggaggt 300 ggtagcaagg ttccacagaa aaaagtaaaa cttgctgctg atgaagatga tgacgatgat 360 gatgaagagg atgatgatga agatgatgat gatgatgatt ttgatgatga ggaagctgaa 420 gaaaaagcgc cagtgaagaa atctatacga gatactccag ccaaaaatgc acaaaagtca 480 aatcagaatg gaaaagactc aaaaccatca tcaacaccaa gatcaaaagg acaagaatcc 540 ttcaagaaac aggaaaaaac tcctaaaaca ccaaaaggac ctagttctgt agaagacatt 600 aaagcaaaaa tgcaagcaag tatagaaaaa ggtggttctc ttcccaaagt ggaagccaaa 660 ttcatcaatt atgtgaagaa ttgcttccgg atgactgacc aagaggctat tcaagatctc 720 tggcaatggg agaagtctct ttaagaaaat agtttaaacc atttggtaaa aaattttccg 780 tcttatttca tttctgtacc agttgatatc ctgctgtcct ttttataatg cnaagtggag 840 aactttccct accggtttgg ataaatgttg gncaggttct attgcccaag aatgtgtgnc 900 ccaaaatgcc cgntagtttt tnaagatgga acttcacccn tttgcttggn tttaagtatg 960 nntngaangt ntgatnggac cntatnntna ccgnggncaa ccttggnaaa tggtggggag 1020 acaa 1024 65 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 65 gggnnnnnnt aactnnacgc ccgcttggta ccgagctcgg atccctagta acggccgcca 60 gtgtgctgga attcgccctt agcgtggtcg cggccgaggt actctgctga tctctgcctt 120 gtaatggaaa tgtttcattc attaatgtta ttgatatggt tgcactatgt ccgtaatttt 180 gctttttgtg tatctgtcta atgtttttta ttctcctttt tctcttttac tattttcttt 240 taaattaagt aaatagttcc taacgtagta ttttattttc ttaaaataaa tcaaactcac 300 ttataaaata tatttcatat tactttctta tcgattgctg tatgccttac aacatacatc 360 ttatcagact caacatttat agtaacataa atccattgag acatagtaac attaattctt 420 tataggtcta tttattctac ttattcaata attgttatat atatattaca tctacatgtt 480 acaaacacaa aaatatattg ttataatgct tgtttttatg taattttatg tcttttaaag 540 aacatgagag aagaaaggaa agcaaagtaa ctattagcat tgttatgtta acattattct 600 ttacaatttc tggttctctt catttttttc ctgttgattc aagttgtatc ttagtgtcat 660 ttcatttctt taatacaact ttgctccaat tatttctttt gtgctcttaa tgtcaaatat 720 attaagtttt gnttgcatta taggctcaac actattatac atatattggt ttatgcattt 780 attttgaatt aagagaaaat aaaaatatgc aatttaatgg cttatatact attcatataa 840 ttaccctcta tgagggtnca ttatatatgn attccaaccn tatttataaa ntccaaanta 900 cctggtangt gccnaaaggc tcctaagcct attagcccgg aaaaaaaatc cctgggtant 960 tccttggnaa gggaggtttg attgccacca acctntttta natngggttg ggttttaata 1020 aacc 1024 66 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 66 ggagnnnnnn ttgngtnngg gccctctaga tgcatgctcg agcggccgcc agtgtgatgg 60 atatctgcag aattcgccct ttcgagcggc cgcccgggca ggtactccag cctgggtaac 120 agagggagac tctatgccaa acaaacaaac aaacaaacaa acaaacaatg gagaccagaa 180 agcaatgaga tgaaatgttc aaagtgctga aagaaaaaaa aaggtcaacc aaaagtctta 240 tatccagaat atttttcaaa gtataaaagc aaaatacatt ctcagataat aaaaacaaaa 300 caaactaaaa gagtttgttg ctatcatacc taccttacaa gaaatactca gtgatttttt 360 tcaggctaat aggctaggag catttggcac ctaacagtaa tttgaattta tatatatgtt 420 tgtatacata tatatggaac actcatagag gtaattatat gaatagttat ataagacatt 480 aaattgcata tttttatttt ctcttaattc aaaataaatg cataaaacaa tatatgtata 540 atagtgttga gcctataatg caaacaaaac taatatattt gacattaaga gcacaaaaga 600 aataattgga gcaaagttgt attaaagaaa tgaaatgaca ctaagataca acttgaatca 660 acaggaaaaa aatgaagaga accagaaatt gtaaagaata atgntaacat aacaatgcta 720 atagttactt tgctttcctt tcttctctca tgntctttaa aagacataaa attacataaa 780 aaccaagcat tataacaata taattttggg tttggaacat ggtagatgta tatatatata 840 ccattattgg ataagtagaa taaataggac tattaaggaa ataatggtac tatggctcaa 900 tgggantaag gtacctataa nggtgagcct gganaggaag natgttgnaa ggcttccggc 960 aatcggttta gaaagtantt tggaaatata ttttnatnaa gngggttgga ttaatttagg 1020 aaaa 1024 67 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 67 gagnnnnnnt taactccagc ttggtaccga gctcggatcc ctagtaacgg ccgccagtgt 60 gctggaattc gccctttcga gcggccgccc gggcaggtac tttttttttt tttttttttt 120 ttttggaaaa tgagattttt gactttaaca aaacaaatac agattgaatt taccaaatat 180 tgataattca tgtanaacgg gtgccacaga ttttaaagta tcaaaaccaa gagggcatca 240 caaaataaac tttggtgaaa aatatcttca tcaaagaaga aaatatgaga agagtagtcc 300 ttatgcagtg aggagaaata tatttggtaa agtaaatatg ggtagtagat actgaatcta 360 tagatagcat atattccaaa tgttttttag ggaatatcaa atcagatgat gcttanatgt 420 tatagtaata tcacttatct catttggaat gaaatttaat gttttttaat aaatagcaaa 480 ttttcatttt ttcactacct ttataaaaca aattaaatat ttagagtata actgatcata 540 actaacatca ccttgcattt actaataaat actctaaata catttggttt attattggaa 600 tttatatcct tataatttta cctgctagaa attagtgacc ttgtggcatt atgtttaaag 660 tttacatttt cccagtgatg tgaacagtat ttatacntaa aatggatatc tgnccaatga 720 atagtaacca tgtttggtgg tttaaaaacc gnacatggtt tagtttgaca ttggcatgtc 780 tcttcagaaa ttnaaaaggt atcntttaag ggatggcttt tnggaaatca ttaataaact 840 accntctggg aaaangaatn ccaatttcaa gaagctacct aantagaact cagacccccn 900 gggcagggtn ttggnanaaa angctttcaa ttncaaattn nttntccgnn gnaaaccgaa 960 ngggaccctt annngnntgg accncctttc cngnaaactg gttttaaaat aaaaatttcc 1020 gnnc 1024 68 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 68 gnngnnnnnn ntnnnttcga attgggccct ctagatgcat gctcgagcgg ccgccagtgt 60 gatggatatc tgcagaattc gcccttagcg tggtcgcggc cgaggtacct agtagatcta 120 ctgagattaa acgggacctg tttggagcag aaccttttga cccatttaac tgtggagcag 180 cagatttccc tccagatatt caatcaaaat tagatgagat acaggagggg ttcaaaatgg 240 gactaactct tgaaggcaca gtattttgtc tcgacccgtt agacagtagg tgctgacatc 300 aagaacaaga aatcctgatt catgttaaat gtgtttgtat acacatgtca tttattatta 360 ttactttaag ataggtatta ttcatgtgtc aatgttttta aatattttaa tattttgaaa 420 attttctcag ttaaatttcc tcaccttcac tattgatctg taatttttat tttaaaaaca 480 gcttactgta aagtagatca tacttttatg ttcctttctg tttctactgt agatgaattt 540 gtaattgaaa gacatattat acaaatacct gccttgtgtc tgagttctat ttagttagca 600 tcttgaaatt tgtattcatt ttccagatgg ctagtttatt aatgatttcc caaaagccat 660 accttaaaga taacttttta aattctgaag agacatgcca atggcaaact aaacatggtc 720 tggttttaaa ccaaccaaca tgttactatt cattgggaca gatatcattt tatggataaa 780 tctggtcaca tactggggaa atggaaactt taaacataat ggccccangg cactaatttc 840 ttaccggtaa aaatnttang ggtttaaant nccatattna acccnatggt tttaaaggat 900 ttattntaaa ngcnngggga ngtanntttg acagtntncn ctaaaanttt aaatgggttn 960 ttaaaggtnt gaaaaaanga aaaattgctt ttttttnaaa acctttaant cntttccnag 1020 gggn 1024 69 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 69 gggnnnnnnn tnncttanac gccnngcttg gtaccgagct cggatcccta gtaacggccg 60 ccagtgtgct ggaattcgcc ctttcgagcg gccgcccggg caggtactcc ggtcggtgtc 120 agcagcacgt ggcattgaac attgcaatgt ggagcccaaa ccacagaaaa tggggtgaaa 180 ttggccaact ttctattaac ttatgttggc aattttgcca ccaacagtaa gctggccctt 240 ctaataaaag aaaattgaaa ggtttctcac taaacggaat taagtagtgg agtcaagaga 300 ctcccaggcc tcagcgtacc tcggccgcga ccacgctaag ggcgaattct gcagatatcc 360 atcacactgg cggccgctcg agcatgcatc tagagggccc aattcgccct atagtgagtc 420 gtattacaat tcactggccg tcgttttaca acgtcgtgac tgggaaaacc ctggcgttac 480 ccaacttaat cgccttgcag cacatccccc tttcgccagc tggcgtaata gcgaagaggc 540 ccgcaccgat cgcccttccc aacagttgcg cagcctgaat ggcgaatgga cgcgccctgt 600 agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcngtgaccg ctacacttgc 660 cagcgcccta cgcccgtcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct 720 ttccccgtca agctctaaat cgggggctcc cttttagggt tccgaattan tgctttacgg 780 accttgaccc caaaaaactt gantanggtg atgggtcacg taatgggccc atnggccttg 840 anaagacggt ttttcgccct ttgacngttg gagtccacgt tctttaaaag gggactcttg 900 gttccaaact ggaacaaccn nttaancctt atttngggct aatcctttgg aattaatnag 960 ggattttgcc caatttgggc ccttnggtta aaaaaagggg cttgntttaa ccaaaaattt 1020 aacc 1024 70 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 70 ggagnnnnnn ttnngtttgg gccctctaga tgcatgctcg agcggccgcc agtgtgatgg 60 atatctgcag aattcgccct tagcgtggtc gcggccgagg tacgctgagg cctgggagtc 120 tcttgactcc actacttaat tccgtttagt gagaaacctt tcaattttct tttattagaa 180 gggccagctt actgttggtg gcaaaattgc caacataagt taatagaaag ttggccaatt 240 tcaccccatt ttctgtggtt tgggctccac attgcaatgt tcaatgccac gtgctgctga 300 caccgaccgg agtacctgcc cgggcggccg ctcgaaaggg cgaattccag cacactggcg 360 gccgttacta gtggatccga gctcggtacc aagcttggcg taatcatggt catagctgtt 420 tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg gaagcataaa 480 gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt tgcgctcact 540 gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc 600 ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg 660 ctcggtcgtt cggctgcggc gagcggtatc aagctcactc aaaggcggta atacngttat 720 ccacagaatc aaggggatac gcaggaaaga acatgtgaac caaaaggcca caaaaggcca 780 ggaacccgta aaaaaggccg cgttggctgg cgttttttcc atangcttcc ggcccccttg 840 acgagcatta ccaaaaatcg acgctcaagt tcaaaggtgg cgaaancccg accggactnt 900 taagaatccc agcgtttncc cctggaactt ccttgggcgc ttttctggtt ccaaccttgc 960 cgttaccgga tacctggncc gcntttttcc ctttngggaa accngggcnt tntcaaaant 1020 taac 1024 71 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 71 gagnnnnnnt taactcccgc ttggtaccga gctcggatcc ctagtaacgg ccgccagtgt 60 gctggaattc gcccttagcg tggtcgcggc cgaggtactt tttttttttc tttttttaca 120 tctgatttta atgcttcgtt aacttcaaaa ggaactggta gagttcagaa ggtgagctgt 180 tgtttttcta aacctcttcc caggaagggg acattgacac ttgaattttt gtcacctttt 240 tcctcattag aaggaaagta gaaagcctta ctgtaggatt tttaaaaaaa aatccatctc 300 accccatatt ggtcttaaat aagtatagac taattaacct aagctacctt taacaacgta 360 gaatttagat gggttcatat atgtgagaaa aacctgaata taggacaggg gtcctacttt 420 tttccccacc tctgtcgccc aggctagagt atagtggtgt gatcttggcc cactgcaacc 480 tctgcttcct aggttcaagt gattctcctg cctcagcctc ccaagtagct gggattgtaa 540 gagtatgcca ccacgcccag ctactttttg tatttttagt agagacaggg tttcatcatg 600 ttggccagga tggtctctta actcctgccc tcaagtgatc caccagagag gagatcctcg 660 gcctccccaa gtgctgggat tataggcatg agccaccgtg cccagcctac tttctaatta 720 attaaaaaaa aaaaaaaaac ttcccaaatg agctgataaa aaactgacgt gaggctgctt 780 tgccttcaat aatacctagt tttcagctgt tccaactcgt ttccaaattg gaaattanct 840 ggaacnccac tacagtaatc ttcanggaan gggaaaatta ggccttaaaa gaatccccag 900 aaagttcanc atnggnancc tgnccnggcc ggnccgttca aaangggcna aatttgcaga 960 aattccatna cacttggcgg gccgttcgan catggctttt aangggccca attgnccctt 1020 aaag 1024 72 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 72 gnagnnnnnn ttnnnttccg aattgggccc tctagatgca tgctcgagcg gccgccagtg 60 tgatggatat ctgcagaatt cgccctttcg agcggccgcc cgggcaggta ccatgctgac 120 ttcttggtat cttttaaggc ctaattttcc cttccttgag attactgtag tgtgttccag 180 ctaatttcta tttggaaacg agttggaaca gctgaaaact aggtattatt gaaggcaaag 240 cagcctcacg tcagtttttt atcagctcat ttgggaagtt tttttttttt ttttaattaa 300 ttagaaagta ggctgggcac ggtggctcat gcctataatc ccagcacttg gggaggccga 360 ggatctcctc tctggtggat cacttgaggg caggagttaa gagaccatcc tggccaacat 420 gatgaaaccc tgtctctact aaaaatacaa aaagtagctg ggcgtggtgg catactctta 480 caatcccagc tacttgggag gctgaggcag gagaatcact tgaacctagg aagcagaggt 540 tgcagtgggc caagatcaca ccactatact ctagcctggg cgacagaggt ggggaaaaaa 600 gtaggacccc tgtcctatat tcaggttttt ctcacatata tgaacccatc taaattctac 660 gttgttaaag gtagcttagg ttaattaagt ctatacttat ttaagaccaa tatggggtga 720 naatggattt ttttttaaaa atcctacagt aaggctttct actttccttc taatgaggaa 780 aaaggtgacc aaaantcaag tggcaatggc ccctttctgg ggaaaagttt anaaaaacca 840 ccggttanct tntggaactt ttacccagtt cccttttgaa gttaccgaag cctttaaaan 900 cagatgttaa aaaaggaaan nnnaaaaagt ncctttggcc gggaacccnc ttaagggcca 960 aattccacac acttgggggg ccgntnccnt anggatccca ncttgggncc aaannttggg 1020 gnaa 1024 73 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 73 gagnnnnnnt tnacttacac gccngcttgg taccgagctc ggatccctag taacggccgc 60 cagtgtgctg gaattcgccc ttagcgtggt cgcggccgag gtactgtgtt atggcacaga 120 caatgcttgc ttagcggtgc cttgttacat aggtggatgc agagtgcgca cacgggatga 180 tggcaataaa gacctcactc agtcgttgga atgaaggaac taggtaactg cttcaacaag 240 gacggtctca gctctacctt atctctcaac agagtgcaaa cactgagtgt gagctcagat 300 gtcatcttgt tcctctttaa aattcaccaa attcttttgc acatttttct gttatagaga 360 cacggatatc ttcttcttca tagtcatcaa agttgctggt atctccagag cctctaaact 420 ttggtatgaa tggagcttca accttcctct ggtaaatagc aatccaatct gtcgtggcaa 480 accacttgtg agtttttata tcactgacac cattctttag atttccaaat ctcttgatca 540 aatccacctg cagcaggttc cgtagaaggt ccttgagatc tgaactgaag tgggatggga 600 atcggacctt tccagaaaca atcttttcat aaatctgaat tggttggtct gcaaagaatg 660 ggggatagcc agctgccatt tcatagatta gcactcctaa tgcccaccaa tccactgcct 720 tattgnagcc cttgctgaga attatttctg gagccaaata cctctggagt tccacataat 780 ggccaagttc tgcctttaac tcttttggca aaccccaaaa gtctgtgacc cgggatatag 840 ccctgatggn ccaatttaag aagaattttc angggtttaa aaactctggt aaatgaaggc 900 taanggaaat ggaggnacct tttttttttt nnnnnnnttt tttttttnaa acnttgtaaa 960 aggccaaaat tttggctana anttantttc aaagnttnaa accntttcca aatttttttt 1020 taat 1024 74 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 74 ggagnnnnnn nttgagttcc ggccctctag atgcatgctc gagcggccgc cagtgtgatg 60 gatatctgca gaattcgccc tttcgagcgg ccgcccgggc aggtacagtc aactgcattt 120 ttctctggtg accaagcttc cactgacaag gaagaggatt atattcgtta tgcccatggt 180 ctgatatctg actacatccc taaagaatta agtgatgact tatctaaata cttaaagcct 240 ccagaacctt cagcctcatt gccaaatcct ccatcaaaga aaataaagtt atcagatgag 300 cctgtagaag caaaagaaga ttacactaag tttaatacta aagatttgaa gactgaaaag 360 aaaaatagca aaatgactgc agctcagaag gctttggcta aagttgacaa gagtgggatg 420 aaaagtattg ataccttttt tggggtaaaa aataaaaaaa aaattggaaa ggtttgaaac 480 tttgaaaata aaatctagca aaaatatttg ctttttacat gttttaaaaa aaaaaaaaaa 540 aaaaaaaaaa aagtacctcc attcactaga cctcatctac agagatctaa aacctgaaaa 600 tctcttaatt gaccatcaag gctatatcca ggtcacagac tttgggtttg ccaaaagagt 660 taaaggcaga acttggacat tatgtggaac tccagagtat ttggctccag aaataattct 720 cagcaagggc tacaataagg cagtgggatt ggtgggcatt aggagtgcta atctatgaaa 780 tggcactggc tatccccatt cnttgcagac ccacccattc agaatttatt gaaaaagatg 840 gttcttggaa ngnccgaatt cccattcccc ttcagntcna actcaagggc ccttttacgg 900 aancctggtt gcanggggga ttgatccagg anaatttgga aatcttaaag aaaaggggnc 960 cggggtttta aaaacctcnc aagngggttt gcccccancg naatgggatt ggtttttccc 1020 ccna 1024 75 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 75 gagnnnnnnt taactcccgc ttggtaccga gctcggatcc ctagtaacgg ccgccagtgt 60 gctggaattc gcccttagcg tggtcgcggc cgaggtacta tatgtatttt attaaaaatg 120 tggaagatta atctgtttct ctctgaatgt agattttcac caaaacatct cttaaaacag 180 cagggactca acacttaaaa atgaactaga agagctgggc acagtggctc acgcctgtaa 240 tcccagcact ttgggaggcc gaggcgggca aatcacttga ggtcaggagt tcgagaccag 300 cctggccaac atggtgaaac cctgtctcta ctaaaaacac aaaaattaac tgggcatggc 360 ggcacacgcc tttaatccca gctactcaag aggctgaggc aggagaatcg ctttgaacct 420 gggaggcaga ggttgcagtg tgctgagatc ataccactgc attccagcct gggcgacaga 480 gcaagactcc acctcaaaaa aaaaaagaag aaaagaaaat agtagtctca gccaggcgtg 540 atggctcaca cctgtaatcc cagcactttg ggaggccaag gtgggcagat cacctgaggt 600 caggagttcg agaccagcct ggcctacgtg gcaaaacctc atctctaata aaaatacaaa 660 aattagcttg ggcgtggtgg catgcacctg tcatcccagc tatttgggag gctgagacag 720 gagaagtcgc tttgaacctg ggangcagaa aattgcggtg aagctaagat cgcacgactt 780 cacttccacc tgggcaaaag anggaactct atctcaaaaa aaaaaaangg aaaaagtagt 840 ctntaagaca ctgggcaaac cttgaaagga attgagcagt cctcactttn ctgnagtcan 900 tttgntnaat gccacatggc tcttttgnaa gaaatttgag agcttttttc taatcccaat 960 ttttntaatt tgggaattcc tttttccgga ttttttcntt gccnggnggt gttcccaang 1020 gcct 1024 76 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 76 gnngnnnnnn ttnnnttgng antngggccc tctagatgca tgctcgagcg gccgccagtg 60 tgatggatat ctgcagaatt cgccctttcg agcggccgcc cgggcaggta ctctttgtgg 120 ctggcttctt tttctgcaca caatgcctat gagaccataa ctaaagtcaa attccatggt 180 cactaaccaa taatggcatc tcaaagaaat tccaacctag agaaattctg atgatgtggt 240 tagaacacca atcaggacac tcacttcatg gttgataatt cccgacatgc actgattcag 300 acccagctta ttgaattcat tgagtccaca ggccagcact ttgcctgact gggtcaacag 360 aaatgtccca tcacagccac attgaactgc aacaataatc aaggccttgg gaacatccac 420 ctgcaagaaa aaaatcagaa aaagaaatcc caaatatata attcgtatta gaaaaaaagc 480 tctcaaattc tttcaaaaga gacatgctgc atttagcaga atgactacag gaaagtgagg 540 actgctctat tcttttcagg tttgcccagt gtcttagaga ctactttttc tttttttttt 600 tttgagatag agtttccctc ttttgcccag gctggagtga agtccgtgcg atcttagctc 660 accgcaatct ctgcctccca ggttcaagcg acttctcctg tctcagcctc ccaaatagct 720 gggatgacag gtgcatgcca ccacgcccag ctaatttttg gatttttatt agagnatgag 780 gttttgccac gtaggccaag ctggncttga acttctgacc ctcaagtgac tggccaccct 840 tgggccttcc aaagtgctgg gaattacagg gngagccatt acgcctggnn tgaaactcca 900 atttcttttc ttcntttttt ttttggnggg gagcttgctn tgcncccaag ctgggaaagc 960 cangggatga cttnnnncac tggaaccttg gcttcaggtt taaagggatt tctggcttaa 1020 nccc 1024 77 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 77 gagnnnnnnt aacttacacg cccgcttggt accgagctcg gatccactag taacggccgc 60 cagtgtgctg gaattcgccc ttagcgtggt cgcggccgag gtactttttt tttttttttt 120 ttttttttac agaaggctgt aaagctttat tgggagaatt ttaatgaaca aatttccaac 180 ataggagcag cctgcatcat ttcaacgtgc cttcttttaa cactgtgatt gcttttcacc 240 ttcttcaggc gttttcacct cctctggatt tggcgggtcc atctcctgcc catcaggacc 300 atcttcacac tcacacccag tctgtgggtg accctgttcc tggctatgag cttcaggctt 360 cggcccttga cctgcanatg ctccctcatc ctctccctcc tgagcagctg caggatcctg 420 acgttgagtt gctggttccc cttcttcagg tgttgctggt tccgcttcat cactgaactg 480 ctcgggccgc ataggcccaa tcatttcagg aggctgnacc tgcccgggcg gccgntcgaa 540 agggcgaatt ctgcagatat ccatcacact ggcggccgnt cgagcatgca tctagagggc 600 ccaattcgcc ctatagtgag tcgtattaca attcactggc cgtcgtttta caacgtcgtg 660 actgggaaaa ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca 720 gctggcgtaa taacgaaaag ccccgcaccg atcgcccttt ccaacagttg cgcancctga 780 aagggcnaaa tggacncccc tggaacggcc attaaccccc gcnggnnnnn gggtaccccn 840 caangngacc ggtacacttg gcaangccct aacgcccggt ccntttgntt ttctttcctt 900 tcnttttngc acgttnnncc gggttttccc ggnaagctnt naaatngggg ggtccccntt 960 tngggtccna ataaggcntt tagggncctt ggnccccnaa aaatttgntt ttnnggggan 1020 ggtc 1024 78 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 78 gnagnnnnnn ttgagtttgg gccctctaga tgcatgctcg agcggccgcc agtgtgatgg 60 atatctgcag aattcgccct ttcgagcggc cgcccgggca ggtacagcct cctgaaatga 120 ttgggcctat gcggcccgag cagttcagtg atgaagcgga accagcaaca cctgaagaag 180 gggaaccagc aactcaacgt caggatcctg cagctgctca ggagggagag gatgagggag 240 catctgcagg tcaagggccg aagcctgaag ctcatagcca ggaacagggt cacccacaga 300 ctgggtgtga gtgtgaagat ggtcctgatg ggcaggagat ggacccgcca aatccagagg 360 aggtgaaaac gcctgaagaa ggtgaaaagc aatcacagtg ttaaaagaag gcacgttgaa 420 atgatgcagg ctgctcctat gttggaaatt tgttcattaa aattctccca ataaagcttt 480 acagccttct gtaaaaaaaa aaaaaaaaaa aaaaaagtac ctcggccgcg accacgctaa 540 gggcgaattc cagcacactg gcggccgtta ctagtggatc cgagctcggt accaagcttg 600 gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac 660 aacatacgag cccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact 720 cacattaatt gcgttgccgc tcactgcccg ctttncagtc gggaaacctg tcgtgccagc 780 tgcattaatg aatcggncaa cgccccgggg aaaaagcggt ttgcgtattg ggcgctcttc 840 gctttcttgg ttacttgact cnttgngcct tggccgttcg gttgcggnna acggtttcag 900 cttacttcaa angcgggaaa tccggttttc cncggaaatc aggggaatac cccnggaaaa 960 gaacttgtga accnaaaggc ccnccaaaag gcccngnaac cgtaaaaaan ggccccntnn 1020 nntn 1024 79 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 79 gngnnnnnnt taacnccagc ttggtaccga gctcggatcc ctagtaacgg ccgccagtgt 60 gctggaattc gccctttcga gcggccgccc gggcaggtac tgtttttgtc atttgcacca 120 gcttctttct ccaggaaaga tcaaaacgat gcactgcaag gttaacatcc aatttttaat 180 acattgtgat tggtccagat agctgcctta tccaactgcc tcctttggac cacttcatca 240 tgggacagct tgatgcaatc tacttgacaa gaccctggaa ccccacaccc ctcatggaac 300 cagtgtccac ctcccagtca cagtgtgacc ccagggaact cttgcctgct tgctttaaac 360 ccaccactta aaagtctcca cagaaaacct gtttgaatag tacctcggcc gcgaccacgc 420 taagggcgaa ttctgcagat atccatcaca ctggcggccg ctcgagcatg catctagagg 480 gcccaattcg ccctatagtg agtcgtatta caattcactg gccgtcgttt tacaacgtcg 540 tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc cccctttcgc 600 cagctggcgt aataagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc 660 tgaatgggcg aaatggacgc gccctgtagc ggcgcattaa gcgcgggcgg gtggtggtgg 720 ttacgccgca gcgtgaccgc tacacttgcc agcgccctta cgcccgctcc tttcgctttc 780 ttcccttcct ttttngcacg ttcggccggc ttttcccgtc agctctaaat cgggggctcc 840 cctttagggt tccgaattan tgctttacgg gaccttganc cccaaaaact tggnttaggg 900 gtgagggtca cgtatgggcc attggccctg aaaanacggt ttttcgcccc tttgaccctt 960 ggaatcncgt nnttttaaaa ggggactttg gtcccaactg ggacaacnnt taacccctta 1020 ttng 1024 80 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 80 gnagnnnnnn ttnnnttgng aattgggccc tctagatgca tgctcgagcg gccgccagtg 60 tgatggatat ctgcagaatt cgcccttagc gtggtcgcgg ccgaggtact attcaaacag 120 gttttctgtg gagactttta agtggtgggt ttaaagcaag caggcaagag ttccctgggg 180 tcacactgtg actgggaggt ggacactggt tccatgaggg gtgtggggtt ccagggtctt 240 gtcaagtaga ttgcatcaag ctgtcccatg atgaagtggt ccaaaggagg cagttggata 300 aggcagctat ctggaccaat cacaatgtat taaaaattgg atgttaacct tgcagtgcat 360 cgttttgatc tttcctggag aaagaagctg gtgcaaatga caaaaacagt acctgcccgg 420 gcggccgctc gaaagggcga attccagcac actggcggcc gttactagtg gatccgagct 480 cggtaccaag cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc 540 tcacaattcc acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat 600 gagtgagcta actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc 660 tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gaaaagcggn ttgcgtattg 720 ggccgctctt ncgcttnctn gcttacttga ctcgcttgcg cttcgnccgt tcggcttgcg 780 gcnaagcggt attcagctta cttcaaaggc ggtaaatacn ggtattcccc agaaatcagg 840 gggatnaccc cnggaaaaga acatgtgaan ccaaaaggcc accaaaaagg ncnnggaacc 900 gtnaaaaang gccncnttnn nnctgngttt ttccattaag gttcccgccc ccttgacagc 960 ctttccaaaa attcganncc ttcaaantnc aaagggggcn aaaaccccnc cggggctttt 1020 taag 1024 81 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 81 gngnnnnnnt taacttacac gccagcttgg taccgagctc ggatccctag taacggccgc 60 cagtgtgctg gaattcgccc tttcgagcgg ccgcccgggc aggtacctca ttagtaattg 120 ttttgttgtt tcattttttt ctaatgtctc ccctctacca gctcacctga gataacagaa 180 tgaaaatgga aggacagcca gatttctcct ttgctctctg ctcattctct ctgaagtcta 240 ggttacccat tttggggacc cattataggc aataaacaca gttcccaaag catttggaca 300 gtttcttgtt gtgttttaga atggttttcc tttttcttag ccttttcctg caaaaggctc 360 actcagtccc ttgcttgctc agtggactgg gctccccagg gcctaggctg ccttcttttc 420 catgtcccac ccatgagccc tccactggac agctcagtaa gcctggccct tcattctgcg 480 ctgtgttctt cctctgtgaa aatccaatac ctcttacctc ctctgcatgc aaagattctc 540 aaggattgtc agacttcaaa cgtaacagca gaaccaccag aaggtcctat aaatgcagta 600 gtgaccttct caagctgtca ggtctttaaa taggatttgg gatttaatgc tatgtatttt 660 taaaggaaag aaataagaag ttgctagttt taaaaatgca tgtcttttaa ccaattcaga 720 atctgccccc aaactttttt naaaagtcaa gacagataaa gctttggggg agacngaaaa 780 aaaaaannnn nnnaaagagt accttnggcc gggaacacgc taangggcaa attctggcan 840 aaatncatta cactgggcgg gcggtttgag cattgcntnt anangggccc aattngncct 900 ataanggggg cgattacaat tncctgggcc gcgttttaaa acgtnngaac tgggaaaanc 960 ctggggtncc cacnttaatg gccttggnga naatccccct tttncccnan tggngnannn 1020 nncn 1024 82 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 82 gnagnnnnnn ttnngtttgg gccctctaga tgcatgctcg agcggccgcc agtgtgatgg 60 atatctgcag aattcgccct tagcgtggtc gcggccgagg tactcttttt tttttttttt 120 ttttccgtct ccccaaagct ttatctgtct tgacttttta aaaaagtttg ggggcagatt 180 ctgaattggc taaaagacat gcatttttaa aactagcaac tcttatttct ttcctttaaa 240 aatacatagc attaaatccc aaatcctatt taaagacctg acagcttgag aaggtcacta 300 ctgcatttat aggaccttct ggtggttctg ctgttacgtt tgaagtctga caatccttga 360 gaatctttgc atgcagagga ggtaagaggt attggatttt cacagaggaa gaacacagcg 420 cagaatgaag ggccaggctt actgagctgt ccagtggagg gctcatgggt gggacatgga 480 aaagaaggca gcctaggccc tggggagccc agtccactga gcaagcaagg gactgagtga 540 gccttttgca ggaaaaggct aagaaaaagg aaaaccattc taaaacacaa caagaaactg 600 tccaaatgct ttgggaactg tgtttattgc ctataatggg tccccaaaat gggtaaccta 660 gacttcagag agaatgagca gagagcaaag gagaaatctg gctgtccttc cattttcatt 720 ctggtatctc aggtgaactg gtaaaaggga gacatttgaa aaaaatgaaa cnaccaaaac 780 cattactaat gaggtacctg cccnggcngg ccgttcnaaa gggccaattc cacacactgg 840 gcggccgtta cttaatggat ccnaactcgg taccaancnt tgcgtaaatc atgggccnnt 900 actgggttnc ctgggggnaa atggtatncg gttaccaatt ccccccaann ttcgancccg 960 gaanccctta agggtaaanc cctgggggcc ctnaagaggg gctaacttcc catttaaatg 1020 ggtt 1024 83 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 83 gggnnnnnnt taanttanac gccnnncttg gtaccgagct cggatcccta gtaacggccg 60 ccagtgtgct ggaattcgcc ctttcgagcg gccgcccggg caggtacact taaaattggt 120 gccgagcagg gatataacct gcagttaagt gaaaagaaaa tccagcctcc ccctccaaaa 180 aaaaaaaaaa atttaatttt taaaaattag tggtatggca ataagacact tcagaggcta 240 tcttaacctc tgaataccca tcttctagtt taaagacaga gacatcccat ctggaaaatg 300 ttaacttgtg ttgtcatctc gttgccggag taagtagaca taagacagag tttaagaagt 360 aaaaatatag aaaaattttg atggtcacaa tgagataaat attagaatat tactattcca 420 atgattaaat gaggatcttg aaataaattc tgaagtcttc caatttttac atttattgga 480 ggggtccctg agttctgtca acttttttat ttaagtctct tgctcttatt ttgtgcataa 540 atgttaaacc ttccaaaaat gaaatgttag ctttctttct tttacttttt attaaattta 600 atagaaaata tgacctgagt agttaaaaag tattttgcat tatttgcagt aagatgtctc 660 tagcactgct caaagggcaa attttaaaac ttcagtctgg gtgaaagatt ttgctagttt 720 tacagaaaga tttgctatct taaactcaaa gctggttttt cttttctcaa tgtaagtgac 780 tgggatgctg gcttaagaat tctttccaag gncatgtttg tgaaataaac cttacatgag 840 agctttcctg ncatctacnc ctatatgtgg cctngaggtt gaccaaattt antttagntt 900 ctaagtgtaa nctatcccaa atgggctatc caaatttgaa tggngccctt catactgnga 960 aggaaaaang tggncctngg ccgggaacac ccttangggc caattttgcg anttccntac 1020 aatt 1024 84 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 84 gnagnnnnnn ttgagntngg ccctctagat gcatgctcga gcggccgcca gtgtgatgga 60 tatctgcaga attcgccctt agcgtggtcg cggccgaggt acagcattat catctcagta 120 tgtagtggca cacattcaaa atcgtataga ccatatgagg atagattaca acttagaaac 180 taaaataaat ttgttcaaca ctccagacaa catatagtgt agatgacagg aaagctctca 240 tgtaatgttt atttcacaaa catgaccttg gaagaattca taagacagca tcccagtcac 300 ttacatgaga aaagaaaaac cagcttgagt ttaagatagc aaatctttct gtaaaactag 360 caaatctttc acccagactg aagttttaaa atttgccctt tgagcagtgc tagagacatc 420 ttactgcaaa taatgcaaaa tactttttaa ctactcaggt catattttct attaaattta 480 ataaaaagta aaagaaagaa agctaacatt tcatttttgg aaggtttaac atttatgcac 540 aaaataagag caagagactt aaataaaaaa gttgacagaa ctcagggacc cctccaataa 600 atgtaaaaat tggaagactt cagaatttat ttcaagatcc tcatttaatc attggaatag 660 taatattcta atatttatct cattgtgacc atcaaaattt ttctatattt ttacttctta 720 aactctgnct tatgnctact tactccggca acgagatgac caccacaagt taacattttc 780 cagaanggat gtctctgnct ttaaactaga aagatgggta tttcagaggg taagaatacc 840 ctctgaagtg gtcttaatgg cataccccta atttttaaaa antaaaattt tttttttttt 900 tgggangggg aaggctggat ttcctttcnc ttaacctnga gggtatatcc cctgnttggg 960 acccaatttt aagngnacct ggcccgggcn ggccgttcaa aagggcgaat ttccgcncct 1020 gggc 1024 85 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 85 gngnnnnnnt taacnccagc ttggtaccga gctcggatcc ctagtaacgg ccgccagtgt 60 gctggaattc gccctttcga gcggccgccc gggcaggtac gcggggagag agaagcgagg 120 ttctcgttct gagggacagg cttgagatcg gctgaagaga gcgggcccag gctctgtgag 180 gaggcaagac acagtgggtc gcaggatctg acaagagtcc aggttctcag gggacaggga 240 gagcaagagg tcaagagctg tgggacacca cagagcagca ctgaaggaga agacctgcct 300 gtgggtcccc atcgcccaag tcctgcccac actcccacct gctaccctga tcagagtcat 360 catgcctcga gctccaaagc gtcagcgctg catgcctgaa gaagatcttc aatcccaaag 420 tgagacacag ggcctcgagg gtgcacaggc tcccctggct gtggaggagg atgcttcatc 480 atccacttcc accagctcct cttttccatc ctcttttccc tcctcctctt ttcctcctcc 540 tcctcctgct atcctctaat accaagcacc ccagaggagg tttctgctga tgatgagaca 600 ccaaatcctc cccagagtgc tcagatagcc tgctcctccc ctcggtcgtt gcttcccttc 660 cattagatca atctgatgag ggctccagca gccaaaagga agagaagtcc cagcacccta 720 caggtcctgc cagacagtga gtctttaccc agaagtgaga tgatgaaaag gngactggat 780 tnggtgcagt ttctgntntt taagtntcaa atgaanggaa ccgatcncaa anggccgaaa 840 tncttggaaa agtgncntna aaaaattatg aagaacnntt tcccttggng gttaangaaa 900 cccctccaan gcnngcnngn nggnctttgg gcnttgangn nnaanggnaa gggatccccn 960 ttgggccnnt tcntttggcc ttggnnncct ncctngggcc ctancttnng aaggggaanc 1020 cnnn 1024 86 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 86 gnagnnnnnn ttnngtttcn gaattgggcc ctctagatgc atgctcgagc ggccgccagt 60 gtgatggata tctgcagaat tcgcccttag cgtggtcgcg gccgaggtac tccaggtagt 120 tttcctgcac ccaatcttgg gtgagcagct tcctgggctc cccataaatg aggtgctcca 180 tcccatcata cagccccatc atattcagtg cttcccagat gacctcctca ggggtgcagt 240 agccctctat gaagattatg cttaggataa gtatgagaat gccagtcttg ggcatgctct 300 ggacatcact cagcatccca tcataggtga ggcccaggga ggtgacaagg acaaaggagt 360 ggccagtggg atccacttcc tttacatcaa tgccaaagac cagcagcatg cactcggagg 420 cttcactaaa caacaaaggg aagtggtctt cataattttt tatgacactc tccagtattt 480 ctgcctttgt gatcggctcc ttcatttgat acttgaagag cagaaactgc accaaatcag 540 tcaccttttc atctatctca cttctgggta aagactcact gtctggcagg acctgtaggg 600 tgcttggact ctcctccttt tggctgctgg agccctcatc agattgatct aatggaaggg 660 aagcaacgac cgagggggag gagcaggcta tctgagcact ctgggggagg aattggtgtc 720 tcatcatcag cagaaacctt ctctggggtg cttggtatta gangatacag gaggaggagg 780 angaagaaga ngaagaagga aaagaggatg gaaaagaagg actgggtgga aatggatgat 840 gaagcatnct tcttcacagc ccaggggaac ctgtgcaccc ttnaagggcc tggggcttac 900 ttttgggaat tgaagaactt ntttaggcnt gccanngntt tacccttttg ganccttnag 960 ggcctnaagn acctttganc angggnnncn nnnnnnngga attgggcncg gaaatttggg 1020 ccna 1024 87 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 87 gggnnnnnnt taactcatac gccagcttgg taccgagctc ggatccctag taacggccgc 60 cagtgtgctg gaattcgccc ttagcgtggt cgcggccgag gtacattgag accagcaata 120 gttccagcat ctttggtagc ctgacgctga gagtcattaa agtaagctgg cactgtgacc 180 acagcattgg taacagtctt cccaaggtag gcttctgcaa tttccttcat ctttgtcaga 240 accatagaag acacctcctc tggatagaag cttttggtct ctcccttgta ttctacttgg 300 accttgggcc tgccagcatc attcaccacc ataaagggcc aatgtttcat atcagactgg 360 acaacagcat catcaaatct gcgtccaatc agacgtttgg catcaaaaac tgtgtcggtg 420 gggttcattg caacttgatt ctttgcggca tcaccgatca accgttcagt gtccgtaaag 480 gcgacatagc ttggagtggt tcggtttccc tgatcattgg caattatctc gacttttccg 540 tgctggaaaa cacccacaca agagtaggtg gtgccaagat caataccaac tgcaggtccc 600 ttggacatgg ttgctgggat gtaggcctgg ctccaataac gaaggaagcc acaaaaaccc 660 aagagctgca ggcgaagtcc aatgagaccc cccgcggacc tgcccgggcg gccgctcgaa 720 agggcgaatt ctgcagatat ccatcacact ggcggccgnt cgagcatgca tctaganggc 780 ccaattcgcc ctataagnga gtcgnattac aatcacttgg ccgcgtttta caacgtcgtg 840 acttgggaaa accctggggt acccaactta atcgncttgn agcacaatcc ccntttnncc 900 anctggcgga antnaccnaa aaggcccgna ccgaacggcc ntttccaaaa gttgcncaan 960 cctgaaangg caaaaggacc ccccccttta acggggccat taaacccccn ncngggnnnn 1020 nngg 1024 88 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 88 gnnnnnnttn ngattgggcc ctctagatgc atgctcgagc ggccgccagt gtgatggata 60 tctgcagaat tcgcccttcg agcggccgcc cgggcaggtc cgcggggggt ctcattggac 120 tcgcctgcag ctcttgggtt tttgtggctt ccttcgttat tggagccagg cctacatccc 180 agcaaccatg tccaagggac ctgcagttgg tattgatctt ggcaccacct actcttgtgt 240 gggtgttttc cagcacggaa aagtcgagat aattgccaat gatcagggaa accgaaccac 300 tccaagctat gtcgccttta cggacactga acggttgatc ggtgatgccg caaagaatca 360 agttgcaatg aaccccaccg acacagtttt tgatgccaaa cgtctgattg gacgcagatt 420 tgatgatgct gttgtccagt ctgatatgaa acattggccc tttatggtgg tgaatgatgc 480 tggcaggccc aaggtccaag tagaatacaa gggagagacc aaaagcttct atccagagga 540 ggtgtcttct atggttctga caaagatgaa ggaaattgca gaagcctacc ttgggaagac 600 tgttaccaat gctgtggtca cagtgccagc ttactttaat gactcttcag cgtcaggcta 660 ccaaagatgc tggaactatt gctggtctca atgtacctcg gcccgngacc acgctaaggg 720 cgaattncag cacactggcc ggccgntact taatggatcc gaactcggta ccaagccttg 780 cgtaatcatg gnccatactg gttnctgngg tgnaattggt attccggtca caattncnca 840 caacattcca anccggaagc cttnagtgta aagccctggg tgcccttaag agtgagctta 900 ctnncantta aatgcgttgc gcttnnttgg ccgttttcca tcgggnaaan ctgcngccaa 960 ctggatttaa ggaattggnc aannccccgg ggaaaaaagn gtttggtatg gcgcttttnc 1020 gttt 1024 89 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 89 gggnnnnnnt taaactccag cttggtaccg agctcggatc cctagtaacg gccgccagtg 60 tgctggaatt cgcccttgag cggccgcccg ggcaggtaca gttcagtaat gttaagtgta 120 ttcacagtgc tgtgcaaaac atttctatct tgcaaaaccg aagttctata tccactaaac 180 aactccgcat tttccctctc cccagcccct gccaactgcc attctacttt ctgtttctct 240 atatttgact acactagaca cctcatacaa gttaaatcag agagtatttg tttttttgtg 300 actggtttct ttaaacttag cataacatcc tcaagatcca tcaatagtct atcatgtatc 360 atgtattact tcttttttaa ggttgaacaa tattccactg tgtgtgtgtg tgtgcacgtg 420 tataccacgt tttgtttagc cattcgtcca tcaatggaac ttgggttgct tcgacccttt 480 ggctactgta ttacgttgtt ctagcattgc tataaagacc tgaggttggg taatttataa 540 agaaaagaag ttctgcaggc tatacaagca tggtgctggc atctgcctgg cttctgggga 600 ggcctcaggg accttttact catggtggaa ggtgaggcag gagcaggcat gccacatggt 660 gaaagcagga gcaagaaaga gtggggaggg tgccatcact taaaaaacca gatcccatga 720 gtattcatta ttgcaagaac agcatcaaac catgaggctt cancccgtgg cccaaacacc 780 ttccaacang ccccaactcg cattaaggat acctttcnaa nntaagggtt gggggggacc 840 aaatntccca actatatcan tgnttttgaa cagggnctcc agttctttta aatcccgaaa 900 aaatttttaa aggantccca acccttttaa ngaactaaag gtttcccgna nnnngaaaag 960 tttttnnccc ngggggnaaa attnaatgnn tttncccnaa aaantaantt ttnaaagaaa 1020 nttt 1024 90 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 90 gnagnnnnnn ttnngttncg aattgggccc tctagatgca tgctcgagcg gccgccagtg 60 tgatggatat ctgcagaatt cgcccttagc gtggtcgcgg ccgcggtaca tctcctaaag 120 actaatggtc atttacaaat tcaaacatga gataaagtat ttggtgatat gtccatcaag 180 tataactcag aaatcagtaa acaagtcttt tcccaaagta agttccttct aaatgtagct 240 aaaaagagcc actttgtcat taaagtgaat gagtatgcat ttttagaaca gacttgatgt 300 ttggattgtg ttaaacatat gtctgttagt gaaagtgtta gtcacaaaga taaaatttca 360 tctaaaaata atatatagag aaaaatgcaa taaatataca catggtaaaa tacttctctt 420 ttctgtaaac ttttagttct ttataagggt tgtgatatca tttaaaaatt tttctgtatt 480 gaaagaaact ggagacactg ttcatagcag ctgatatagt ttggatattt gtccccaccc 540 aaaccttata ttgaaatgta atccttaatg cggaggtggg gcctggtggg aggtgtttgg 600 gccacggggg tggagcctca tggtttgatg ctgttcttgc aataatgaat actcatggga 660 tctggttttt aaagtggatg gcaccctttc ccactctctc ttgctcctgc tttcaccatg 720 tggcatgcct gctcctgcct caccttcacc atgagtnaaa ggncctgang cctcccagaa 780 gccangcaga tgccancanc attgcttgga tagcctgcan aacttctttt ctttataaaa 840 taccccaacc tnaggcntta tgccatgctt gaacaaccgt aatncntanc ccaanggtcn 900 aaccaaccca ggtccattgg nngggcnaag gnttaacnaa acgnggnntc ccntgcncna 960 nnnncccccn ggggnaaatg gcaacccttn aaaanaagnn tncctgganc cngnnnnncc 1020 nttt 1024 91 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 91 gggnnnnnnt aattancgcc ngcttggtac cgagctcgga tccctagtaa cggccgccag 60 tgtgctggaa ttcgccctta gcgtggtcgc ggccgaggta ccttggaagt tatgtcatta 120 atataggctg gttcatcaaa taaagcaaaa ccttgcaata tcagctagat ttacactccg 180 ggacgttgcc caaaggtagg aagaaagcag agggaaatat ttcagtcatc atttccaaag 240 tcattatcaa aatctgtgag gaagtttaat cttccaaaga gtcaatgtca gacatcaggc 300 ctctgttgcc tgcttctctc gaggcactag attaggagtc ttcaataaga gacttaacat 360 gaggtatatg gaagatgagg caccgagata agttcatcat taggtgtgag cactgctcac 420 ccttgctggc aagttctcct taagggcctg aagcacaggt gtccaaagaa aagcgttaag 480 tccatcttaa tagaatctat gtggtatatg atgtggtcag cccctggtct gtgatcagca 540 agaacctaca gcacagatta tgccctgccc acttcaatga atacctactc tcctccattc 600 tccatcactt tttttgctat caagaactcc ggaccttgcc catgggagaa gtttagagag 660 gaactcttgt ggagaactgg tttattttct gccctgtgcc gacgagtttc agctggccaa 720 gaaaggagtc aagttattaa aaagcatcac aatggagatc ttccaggctg ggttttttgg 780 tttttggtgg taaaactggg ggaaangggg actatttatt ctggccttaa atcaatnggc 840 aaattaagtc aagaagaccn ttttgggaat gtngactatg gatnccctcc taatngaatg 900 gagnagcctt aaaaaggggg caangtaang gttttcnggt atggaagcca aaanttttnc 960 cggctnaatg ggntggntnn ccaatattnn taccggcccn aaangggnnt tttncnnngg 1020 gtcc 1024 92 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 92 nngnnnnnnt tnngantggg ccctctagat gcatgctcga gcggccgccc gggcaggtac 60 tgcatccata atttatcgcc atgtgcaaca gctttgcgtt ttctaaggca caatttttaa 120 tgaaatgatg tgtagatttc aatctaataa cagctcatcc aaatgacaaa tatggtcgaa 180 atccctccag tggctgagga aatttctgca cctatatgga acccacatgc aaagaaccca 240 tctagcatgt aataaataat cgctagccat actcaataag acacggaaaa attattgctt 300 acataacaga aaaacatcta cttgaccccc ttttatgact acatcaatct attaggagtg 360 tatccatagt ctacattcac aaaatgtcat cttgacttat ttgccattga tttaaggcag 420 aataaatagt ccccctttcc ccagtcttaa caacaaaaaa caaaaaacca gcctggagat 480 ctacattgtg atgcttttta ataacttgac tcctttcttg gccagctgaa actcgtcgca 540 cagggcagaa aataaaccag ctctccacaa gagttcctct ctaaacttct ccatgggcaa 600 ggtccggagt tcttgatagc aaaaaaagtg atgggagaat ggaggagaag taggtattca 660 ttgaagtggg cagggcataa tctgtgctgn aggttcttgc tgatcacaga ccaagggctg 720 accacatcat ataccacata gattctatta agaatggact taacgctttt ctttggacac 780 ctgtgcttta ngccctttaa ggagaacttg ncanccangg gtgagcagtg cttcacacct 840 taaggatgaa ccttaatctc ggggcctcat cttccatata nccctaaggg taagnctctt 900 taatggaaga ctcctnaatt agnggccttg aaaagaagca ggcacccgaa gggcctgagg 960 ctgacattgg ctcttttnga agaataaact ttccttaccg naatttggaa aaggaccttt 1020 ggaa 1024 93 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 93 gngnnnnnnt taactccagc ttggtaccga gctcggatcc ctagtaacgg ccgccagtgt 60 gctggaattc gcccttagcg tggtcgcggc cgaggtactt tttcaaatgt cactgaaaga 120 attgtttttg taacagtatg caaaatgata ctgtattgtt agaacaaaaa tctgtggagt 180 gttaatactt tgtaagccaa attaaagttt ctaagcagta taaaatgaga atgacatcat 240 cctttcctag tatttccaag tcttagagta ctctacaccc tgttggctat ttatctgggg 300 ttagacttct ggagactttt cagatagact tgaagtctct ggccttgcct gggaattact 360 ggctgcccaa ggaagcactg gagaaggcgg tggtctcctt gcccttgtgg tcctgctgtg 420 gcgcattttg attgagttcc tggttcggct ggtcagagtg gctggatagt gttggcccac 480 tccattcctc aggttttttt gaagcggtgg tcttttaggg agagcctttt gttcctggaa 540 cttccttgac gggtcccttt tcccttctgg gttgtcttgg gaacctcttt ggtgttgatg 600 ggttgttgtt ggaaaatggg ctggaggctc gtggtttcct ggacatcttc accagaccag 660 tgtctctcaa cagtctactc cagtccacct ggtctncccg agcttcccca ggacagtgaa 720 ngcaggccac aggctanaaa ctgtagtcnc ccgacattac aagccaattt gggnctgtgg 780 gctctgnttt ccaaatcaac cctttcanct tcatttggaa ncccattcag gaaanccccg 840 cgtaccttgc ccgggcgggc cgttcnaaag ggcgaattct gcanaaatcc cttanacttg 900 ggnggnccgt ttnaacctgc cttttaaagg gcccaattnn nccctntnna nnggagcgan 960 taccaattnn ntnggnccgc gttttnaaaa cgnnnnnann tnggnaaaan ccctggggtn 1020 cccc 1024 94 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 94 ttnngaattg ggccctctag atgcatgctc gagcggccgc cagtgtgatg gatatctgca 60 gaattcgccc ttcgagcggc cgcccgggca ggtacgcggg gcttcctgga tggggatcca 120 gatggaggtg gagggttgat ttgggaagca gagcacagca gcacaaattt gcttgtaatg 180 tcggcgacta cagtttctag cctgctggcc tgccttcact gtcctggggg aagctcgggg 240 agaccaggtg gactggagta gactgttgag agacactggt ctggtgaaga tgtccaggaa 300 accacgagcc tccagcccat tttccaacaa ccacccatca acaccaaaga ggttcccaag 360 acaacccaga agggaaaagg gacccgtcaa ggaagttcca ggaacaaaag gctctcccta 420 aaagaccacc gcttcaaaaa aacctgagga atggagtggg ccaacactat ccagccactc 480 tgaccagccg aaccaggaac tcaatcaaaa tgcgccacag caggaccaca agggcaagga 540 gaccaccgcc ttctccagtg cttccttggg cagccagtaa ttcccaggca aggccagaga 600 cttaagtcta tctgaaaagt cttccagaag tctaacccca gataaatagc cnaacagggt 660 ggagagtact tctaagactt ggaaatctta ggaaagggat gatgtcantc tcattttata 720 ctgnttaaaa actttaantt ggcttacaag tattaaccct tcacagaant ttgtctacca 780 tncagnatca atttggcatc tggtccaaaa ccattttttt agggcanttt gaaaagtcct 840 tnggccggga acaccttaag ggcgantcca gncacttggg nggncgtnan nnnaaggtcc 900 caactcgnnc caaannttgn gnaaacatgg gnnnanatgg gntcctgggg ggaaatgtat 960 ccgnttacaa nttcccncaa nntncnaanc cggannncnt taagggtaaa nnccctgggg 1020 gccc 1024 95 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 95 gggnnnnnnt taactccagc ttggtaccga gctcggatcc ctagtaacgg ccgccagtgt 60 gctggaattc gccctttcga gcggccgccc gggcaggtac tttttttttt tttttttttc 120 cgtctcccca aagctttatc tgtcttgact ttttaaaaaa gtttgggggc agattctgaa 180 ttggctaaaa gacatgcatt tttaaaacta gcaactctta tttctttcct ttaaaaatac 240 atagcattaa atcccaaatc ctatttaaag acctgacagc ttgagaaggt cactactgca 300 tttataggac cttctggtgg ttctgctgtt acgtttgaag tctgacaatc cttgagaatc 360 tttgcatgca gaggaggtaa gaggtattgg attttcacag aggaagaaca cagcgcagaa 420 tgaagggcca ggcttactga gctgtccagt ggagggctca tgggtgggac atggaaaaga 480 aggcagccta ggccctgggg agcccagtcc actgagcaag caagggactg agtgagcctt 540 ttgcaggaaa aggctaagaa aaaggaaaac cattctaaaa aacaacaaga aactgtccaa 600 atgctttggg aactgtgttt attgcctata atgggtcccc aaaatgggta acctagactt 660 cagagagaat gagcagagag caaaggagaa atctggctgc cttccatttt cattctgnta 720 tctcaggtga actggtanan gggagacatt ngaaaaaaat gaaacnacca aaaccattac 780 taatgaggta ccttnggncc gggaacacgc ttaaggcgaa ttttgcagaa atncattaca 840 ctggcggncc gttcagcatg cttttaaagg gcccaattnc cctttaaggg agtcgnatta 900 caatttnant gggccgcgtt ttacaacgtn nggaactggn aaaacccctg gggtnnccca 960 cttnaannnc cttggnnnan aatccccttt tnccnaantg gggnnnnnnn ccaaaggccc 1020 cnna 1024 96 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 96 gngnnnnnnn tnngttncga ntgggccctc tagatgcatg ctcgagcggc cgccagtgtg 60 atggatatct gcagaattcg cccttagcgt ggtcgcggcc gaggtacctc attagtaatt 120 gttttgttgt ttcatttttt tctaatgtct cccctctacc agctcacctg agataacaga 180 atgaaaatgg aaggacagcc agatttctcc tttgctctct gctcattctc tctgaagtct 240 aggttaccca ttttggggac ccattatagg caataaacac agttcccaaa gcatttggac 300 agtttcttgt tgttttttag aatggttttc ctttttctta gccttttcct gcaaaaggct 360 cactcagtcc cttgcttgct cagtggactg ggctccccag ggcctaggct gccttctttt 420 ccatgtccca cccatgagcc ctccactgga cagctcagta agcctggccc ttcattctgc 480 gctgtgttct tcctctgtga aaatccaata cctcttacct cctctgcatg caaagattct 540 caaggattgt cagacttcaa acgtaacagc agaaccacca gaaggtccta taaatgcagt 600 agtgaccttc tcaagctgtc aggtctttaa ataggatttg ggatttaatg ctatgtattt 660 ttaaaggaaa gaaataagaa ttgctagttt taaaaatgca tgtcttttaa ccaattcaga 720 atctgccccc aaactttttt naaaagtcaa ggaccgataa agctttgggg agacngaaaa 780 aaaaaannnn aaaaagtacc tgcccgggcn ggccgttcna aagggcgaaa ttcaacacac 840 tgggcggccg gtacttaatg gatcccaact cggncccaac cttggggaaa ncatgggccn 900 taactgggtt cccggggggn aaatggtatt ccggttacaa attccccccc annttccana 960 cccggaaanc cnttaagggt aaaanccctg ggnggcccna anggggggct nacctcccct 1020 tnaa 1024 97 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 97 gnngnnnnnn nttnnnttat acgccangct tggtaccgag ctcggatccc tagtaacggc 60 cgccagtgtg ctggaattcg cccttagcgt ggtcgcggcc gaggtacatc tgattttata 120 tgttgtccaa actggtcaat ccagttgctt aacacagaaa gcggacagat gatcagtgtt 180 gttcttggtc tctcctcaac atcagttttc tttgacccct ccactgcaca agctcccttt 240 ttcaacattt tcttttttgt tgtaggaaca gatgaagtta atgcacatgc aaatgccaca 300 tcttctataa ccttagaaga tcctttcgcc ctgcctttag tttcagactg tacagaggga 360 gagagagaga gaaagagagc acgccagtga gaaagcgagc gcgagcgcga gcgcaagggg 420 aggagagggt gggagagggc ggaaggggga aagctgtccg tgggagattg tgtcttcatg 480 tccacggggc tgcatctctt gatggtgcac tgaaaaagca gagctcacca gacagagtgg 540 aaaggcaggg ggaggggcag ggagcaacag aaggaagaga caacaagccc aagacagctt 600 ccatctcaga cggaaggccc ccagaagata gaattccagc cgactgaaaa accacccaat 660 gaacaaagaa gattctagaa aatagaagtg ttgggattac aaagttgngc gtttcatcgg 720 tacctgcccg ggcggncgnt caangggcga attctgcaga tatccatcac actggcggnc 780 gntcgagcat gcatntagan ggcccaantc gncctataag ggagtcgnan tacaattcac 840 ttgggccgcg ttttacaacg tctgacttgg naaaanccct gnggttnccc aacnttaaac 900 ggcnttggag nacaattccc ctttttncca anntggggna antnaccaaa agggccccnn 960 accgatggnc cttttncaaa aagttgggcc aaccttgaaa gggcaaaagg gcccccccct 1020 ttaa 1024 98 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 98 gnngnnnnnn ttnngaatgg gccctctaga tgcatgctcg agcggccgcc agtgtgatgg 60 atatctgcag aattcgccct tgagcggccg cccgggcagg taccgatgaa acgcgcaact 120 ttgtaatccc aacactttct attttctaga atcttctttg ttcattgggt ggtttttcag 180 tcggctggaa ttctatcttc tgggggcctt ccgtctgaga tggaagctgt cttgggcttg 240 ttgtctcttc cttctgttgc tccctgcccc tccccctgcc tttccactct gtctggtgag 300 ctctgctttt tcagtgcacc atcaagagat gcagccccgt ggacatgaag acacaatctc 360 ccacggacag ctttccccct tccgccctct cccaccctct cctccccttg cgctcgcgct 420 cgcgctcgct ttctcactgg cgtgctctct ttctctctct ctctccctct gtacagtctg 480 aaactaaagg cagggcgaaa ggatcttcta aggttataga agatgtggca tttgcatgtg 540 cattaacttc atctgttcct acaacaaaaa agaaaatgtt gaaaaaggga gcttgtgcag 600 tggaggggtc aaagaaaact gatgttgagg agagaccaag aacaacactg atcatctgtc 660 cgctttctgt gttaagcaac tggattgaca gtttggacaa catataaaaa tcagatgtac 720 ctcggncgcg accacgctta gggcgaattn cagcacactg ggcggccgtt acttaatgga 780 tccgaactcg naccaagcct tgcgtaaaca tgggcaatac tggnttcctg nggggaaatg 840 gtaatccggt tacaaattcc ccacaacntt acaanccgga agcccttaag ngtaaaaccc 900 ctgggngccc caaagagtga gctaacttnc catttaaatg cgttngctca atggcccgtt 960 ttccatcggg naaaacctgn ngccantgga ttaangaatc ggncaaancc cccggggnaa 1020 aaan 1024 99 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 99 aacgccagct tggtaccgag ctcggatccc tagtaacggc cgccagtgtg ctggaattcg 60 ccctttcgag cggccgcccg ggcaggtaca gataaatccg tgcatgcatt gagggagact 120 agagggtaaa atgaaatctg ccccatcctt cttacataca cagtgatagc attttgaatt 180 gttcttctac atttgaaatc ttagctgaaa gatcatcagc caccgacctt ttgtgaagct 240 agttctctag aacatacaat gttttttaaa aaattaaaaa cacagaagga aaaaagcaag 300 aaccaacgat aaatggagct tgtgcagaat ctggcagtgc tgtggacctg cccatctgtt 360 ctcccccgcg tactgactga acacactccc cgctttggtt cctgtaggac gggtgagata 420 ccacaccttg gcaaccacca gtaaaggctc atagtctagc ccttgggagg ccccgatttt 480 agggctgtgc tcggaggcga cctacgttag ggactgggag aagcgggtac ctcggccgcg 540 accacgctaa gggcgaattc tgcagatatc catcacactg gcggccgctc gagcatgcat 600 ctagagggcc caattcgccc tatagtgagt cgtattacaa ttcacttggc ccgtcgtttt 660 acaacgtcgt gactgggaaa accctgccgt tacccaactt aatcgccttg cagcacatcc 720 ccctttcgcc agctgcgtaa taacgaaaag cccgnaccga tcgccctttc cacagttgcg 780 caacctgaat ggcnaatgga cccccccttg taccggcgca ttaaccnccn gccggntnnt 840 ggggtacccc cacgtggacc ggttcacttg gccagggccc taangnccgg ttcntttggt 900 ttcttncctt ccntttttng cccgttngcc nggtttttcc cgtaagcttt taaanngggg 960 gcttcccctt ttangggtcc aaataangct ttacgggncc tttaaccccc aaaaaaattt 1020 nnnt 1024 100 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 100 gggnnnnnnn ttnngttcng aattgggccc tctagatgca tgctcgagcg gccgccagtg 60 tgatggatat ctgcagaatt cgcccttagc gtggtcgcgg ccgaggtacc cgcttctccc 120 agtccctaac gtaggtcgcc tccgagcaca gccctaaaat cggggcctcc caagggctag 180 actatgagcc tttactggtg gttgccaagg tgtggtatct cacccgtcct acaggaacca 240 aagcggggag tgtgttcagt cagtacgcgg gggagaacag atgggcaggt ccacagcact 300 gccagattct gcacaagctc catttatcgt tggttcttgc ttttttcctt ctgtgttttt 360 aattttttaa aaaacattgt atgttctaga gaactagctt cacaaaaggt cggtggctga 420 tgatctttca gctaagattt caaatgtaga agaacaattc aaaatgctat cactgtgtat 480 gtaagaagga tggggcagat ttcattttac cctctagtct ccctcaatgc atgcacggat 540 ttatctgtac ctgcccgggc ggccgctcga aagggcgaat tccagcacac tggcggccgt 600 tactagtgga tccgagctcg gtaccaagct tggcgtaatc atggtcatag ctgnttcctg 660 tgtgaaattg ntatccgctc acaattccac acaacatacg agcccggaag ccataaagtg 720 tnaaagccct ggggtgcctn atgagtgagc taactcacat ttaattgcgt tgcgctcact 780 ggcccgnttt cagtcgggaa aactgcntgc cactgcttaa tgaatcggcc acgccccggg 840 gaaaaagcgn ttgcgtantg ggcgctnttc cgctttcttg gttaactgac tcnttgggct 900 ttggccttng gnttnnggnn aacgggttna acttncnttn aaangggggn naatccggtn 960 tnccccgaaa nncggggata acccccggaa anaactttgn ccnaaaggcc cccnaaangg 1020 cccn 1024 101 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 101 gggnnnnnnt tgaatnacac gccagcttgg taccgagctc ggatccctag taacggccgc 60 cagtgtgctg gaattcgccc ttagcgtggt cgcggccgag gtacgcgggt attttcttaa 120 atttcttgaa tgttctttat ggtagtgtta ctaaaaagtt tatgatcaca ttttcattgt 180 gaacataatt tgaactcatt atcacacact tggaaaatac agaaaagtgg aggaaaaaaa 240 atcatatccc caccatccaa agacatatac tctcctctta tcttgttcat tcttgtttct 300 gtgcacaggt ttatgattat aactgtgtca aaatgtatat tcaaaatagc tgttacatta 360 cctttgtgga attatggtta aatactttca ctttaatttt ttcaaatgtt ccctataata 420 atgttctgat aacagtgtat tatgtgtgtc tccattggtg tgcataatac atacccagag 480 gaaaaattag aaaataaagt aaattatttt aaaaaattac ctatattccc aacacctaac 540 aactactgct aacatcttga tctgtttcct ctatcttgtt tcagtgcaca cgcttgtgat 600 aacagtgtta aatatgtgtg cataaagtct taaatgaaaa gatgtggaaa ataactaaaa 660 tagtgttgtc attgtgggaa tttggttaaa tattttgtct caaattcctt aaataatctt 720 tggtgttttg gtaataaatt ttaatgatgt attttccatt acaaatataa tacatactca 780 tacaaaactt tggaaaatta gtaaagaaaa ttcacacata ttcccacacc caacaccaat 840 ttaactggtn accatctgga ctgngcncta agctgggatt antttaggng tagtggataa 900 gtatgcctaa aggccaaaaa tgggaagaag gatgaaaanc cngaaaatan ttnccctggt 960 gtnnggggaa taaggggaat ttgggttcgg ttcctttgaa agggcatnnn tttcaagggg 1020 tttg 1024 102 1020 DNA Homo Sapien misc_feature (1)...(1020) n = A,T,C or G 102 ggagnnnntt aaacgccagc ttggtaccga gctcggatcc ctagtaacgg ccgccagtgt 60 gctggaattc gccctttcga gcggccgccc gggcaggtac tctttctctc ccctcctctg 120 aatttaattc tttcaacttg caatttgcaa ggattacaca tttcactgtg atgtatattg 180 tgttgcaaaa aaaaaagtgt ctttgtttaa aattacttgg tttgtgaatc catcttgctt 240 tttccccatt ggaactagtc attaacccat ctctgaactg gtagaaaaac atctgaagag 300 ctagtctatc agcatctgac aggtgaattg gatggttctc agaaccattt cacccagaca 360 gcctgtttct atcctgttta ataaattagt ttgggttctc tacatgcata acaaaccctg 420 ctccaatctg tcacataaaa gtctgtgact tgaagtttag tcagcacccc caccaaactt 480 tatttttcta tgtgtttttt gcaacatatg agtgttttga aaataaagta cctcggccgc 540 gaccacgcta agggcgaatt ctgcagatat ccatcacact ggcggccgct cgagcatgca 600 tctagagggc ccaattcgcc ctatagtgag tcgtattaca attcactgcc cgtcgtttta 660 caacgtcgtg actgggaaaa ccctgcgtta cccaacttaa tcgccttgca gcacatcccc 720 ctttcgccag ctggcgtaat aacgaaaagc cccggaccga tcgccctttc caacaggtgc 780 gcaacctgaa tggcgaaatg gaccccccct ggaaccggcg cantaaaccc ccgncgggnn 840 nntngggtac cccccacggg ganccgttca cttggccann gccctaangn cccgttcctt 900 tnggtttctt tccttccttt ttgcccgttt gnccgggttt tcccggnaag ctttaaaaac 960 gggggcctcc ccctttangg gtccnaataa nggcttttac gggnccttng aaccccaaan 1020 103 1021 DNA Homo Sapien misc_feature (1)...(1021) n = A,T,C or G 103 ggagnnnttn ngnngggccc tctagatgca tgctcgagcg gccgccagtg tgatggatat 60 ctgcagaatt cgcccttagc gtggtcgcgg ccgaggtact ttattttcaa aacactcata 120 tgttgcaaaa aacacataga aaaataaagt ttggtggggg tgctgactaa acttcaagtc 180 acagactttt atgtgacaga ttggagcagg gtttgttatg catgtagaga acccaaacta 240 atttattaaa caggatagaa acaggctgtc tgggtgaaat ggttctgaga accatccaat 300 tcacctgtca gatgctgata gactagctct tcagatgttt ttctaccagt tcagagatgg 360 gttaatgact agttccaatg gggaaaaagc aagatggatt cacaaaccaa gtaattttaa 420 acaaagacac tttttttttt gcaacacaat atacatcaca gtgaaatgtg taatccttgc 480 aaattgcaag ttgaaagaat taaattcaga ggaggggaga gaaagagtac ctgcccgggc 540 ggccgctcga aagggcgaat tccagcacac tggcggccgt tactagtgga tccgagctcg 600 gtaccaagct tggcgtaatc atggtcatag ctgnttcctg tgtgaaattg gtatccgctc 660 acaattccac acaacatacg agcccggaag cataaagtgt aaagccctgg ggtgcctaat 720 gagtgagcta actcacatta aatgcgttgc gctcactggc cgctttncag tccgggaaac 780 ctgtcgtgcc agctgcatta atgaatccgg ncaacgcccc ggggaaaaag cggttgcgta 840 ttgggcgctc ttncgctttc ttggttactg gctccttgng cctcggccgt tccggnttcg 900 gnnaaccggt atcagcttac ttcaaangcg gnaaatccgg tttncccnga aatccggggg 960 ttaacnccag gaaaanaacc tttgaaccna aagggccccn aaaagggccc ggaaccctaa 1020 a 1021 104 1017 DNA Homo Sapien misc_feature (1)...(1017) n = A,T,C or G 104 ggagnnntta atcnacgccn gcttggtacc gagctcggat ccctagtaac ggccgccagt 60 gtgctggaat tcgcccttag cgtggtcgcg gccgaggtac tcagctgtct taataggatg 120 aagccttaag cagtggaaat ttcagttatt ttccacagta ttccattttg gaggatttgg 180 ggtgtttact ttttaaattc ttgaacaact taacctccat gaggctttgt gaagtcagct 240 gtgaccaccc tcctcttact gtgttctcag tattcattca cttccaggga agaatgacag 300 ccacagggag atggtggtgg gcaagaatga gagtcccagg atccagattt agcctcagat 360 cttccccatt caggaagggt tttccattta acaagagcac tagtatgaaa acattaggga 420 caaatctccc atgtctttga aattcggatt ctcctcttga gatccccttc ctcacctgcc 480 aatcaacttt ataaggccac aagtggtcac tggttttcct tccacaggtt tgaggttctc 540 agctttcctt aagcgaccca gcagctccgc tgttttcaga gtgaatatgt taagctttga 600 tgagattcta ttttcagtaa gttagtgctt ctgggacact tggagaaagc tgtgagagtc 660 attggctacg caaagaacaa cgaaagctga tcctaaaagt gatccaatct aagaaaatgg 720 taaaacgagc tctggccaca gcacagaatt ttatgtgang aactcagatt tttgaagact 780 taacaattgc agaaaaaggn tgcagcctgn acacccatag cccaactttt ntgagccana 840 ctttgggttt tgggngggga cntggcacca tgtttgnacc tggccggccg gnccgttcna 900 aagggccaaa ttntggcnga aatnccttac actggggggc cgtttgagca tgcctntaaa 960 ngggcccaan tngnccctta aaggggggcn nnttccaatt nnctgggccc ggttttn 1017 105 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 105 ggagnnnntt nnntnnngan tgggccctct agatgcatgc tcgagcggcc gccagtgtga 60 tggatatctg cagaattcgc cctttcgagc ggccgcccgg caggtacaaa catgtgccac 120 gtcaccacac aaaaccaaag tctgctcaga gaggtgggct atggtgtgca ggctgcaacc 180 tttctctgca attgttaagt cttcaaaaat ctgagttcct cacataaaat tctgtgctgt 240 ggccagagct cgttttacca ttttcttaga ttggatcact tttaggatca gcttcgttgt 300 tctttgcgta gacaatgact ctcacagctt tctccaagtg tcccagaagc actaacttac 360 tgaaaataga atctcatcaa agcttaacat attcactctg aaaacagcgg agctgctggg 420 tcgcttaagg aaagctgaga acctcaaacc tgtggaagga aaaccagtga ccacttgtgg 480 ccttataaag ttgattggca ggtgaggaag gggatctcaa gaggagaatc cgaatttcaa 540 agacatggga gatttgtccc taatgttttc atactagtgc tcttgttaaa tggaaaaccc 600 ttcctgaatg gggaagatct gaggctaaat ctggatcctg ggactctcat tcttgcccac 660 caccatctcc ctgtggctgt cattcttccc ctgaagtgaa tgaatactga gaacacagta 720 aggaaggagg gtggtcacaa gctgacttca caaagcccta atgganggtt aagttggtca 780 agaatttnaa aagtaacccc cccaaatcct ccaaaaatgg gaatactggt ggaaaataac 840 ctggaaattn ccctggttta aggcttcatt ctattaagac cgcttgagta cccttggccg 900 ngaaccccct taagggcgaa ntncaacaca ctgggngggc cggtacctaa nggatcccaa 960 ctnggnaccc aancnttggg gaaancatng ggccataact gggttcccgg ggggaaatgg 1020 taat 1024 106 1007 DNA Homo Sapien misc_feature (1)...(1007) n = A,T,C or G 106 ggagnnnntt aaacgccagc ttggtaccga gctcggatcc ctagtaacgg ccgccagtgt 60 gctggaattc gcccttagcg tggtcgcggc cgaggtacac agaatagctg agcagttcac 120 ttcagggatc aggtcatctc tgctcctcct agtttcacca tgttctggca ataaaaaaca 180 catattatat cctggttttc tctatccttg cattactaag gtgactgtct ctctttatac 240 atccttgtat ggttctccca gtattagcaa gattgtatat ctgtaaagaa tgtccagttt 300 tgtaaatatt tccctgcctt tttttttctt tttttacatc tgattttaat gcttcgttaa 360 cttcaaaagg aactggtaga gttcagaagg tgagctgttg tttttctaaa cctcttccca 420 ggaaggggac attgacactt gaatttttgt cacctttttc ctcattagaa ggaaagtaga 480 aagccttact gtaggatttt taaaaaaaaa tccatctcac cccatattgg tcttaaataa 540 gtatagacta attaacctaa gctaccttta acaacgtaga atttaanatg ggttcatata 600 tgtgagaaaa acctgaatat aggacagggg tcctactttt ttccccacct ctgtcgccca 660 ggctagagta ntaantggtg gatcttggcc cactgcaacc tctgcttcta gggtcaagtg 720 attctcctgc tcagcctncc aagtancccg ggaattggaa gagtatgcca ccacgcccag 780 ctactttttg gaattttagt nnaaaacagg ttcatcatgn tggncccnga agggcnctta 840 antcctgncc ttnagngatc cccccnnana ngaaaccntg gncnncccaa nnnncnggnn 900 tntagcnnnn ccnccgngcc cannctactt tnnnaannnn nnnnnnnnnn nnnnnnnnnn 960 nnnnnnnnaa nnngnncnnn nccngnnngn ccnnnnnngg gnaantc 1007 107 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 107 gnagnnnnnn nngattgggc cctctagatg catgctcgag cggccgccag tgtgatggat 60 atctgcagaa ttcgccctta gcggccgccc gggcaggtac tttttttttt tttttttttt 120 tttttttttt aattaattag aaagtaggct gggcacggng gctcatgcct ataatcccag 180 cacttgggga ggccgaggat ctcctctctg gnggatcact tgagggcagg agttaagaga 240 ccatcctggc caacatgatg aaaccctgtc tctactaaaa atacaaaaag tagctgggcg 300 tggtggcata ctcttacaat cccggctact tgggaggctg aggcaggana atcacttgaa 360 cctaggaagc agaggttgca gtgggccaag atcacaccac tatactctag cctgggcgac 420 agaggtgggg aaaaaagtag gacccctgtc ctatattcag gtttttctca catatatgaa 480 cccatctaaa ttctacgttg ttaaaggtag cttaggttaa ttagtctata cttatttaag 540 accaatatgg ggtganatgg attttttttt aaaaatccta cagtaaggct ttctactttc 600 cttctaatga ggaaaaaggt gacaaaaatt caagtgtcaa tgccccttcc ttggggaaga 660 ggtttagaaa aacaacagct caccttntga acttttacca gttccttttt gagttaaccg 720 aagcnttaaa aatcagatgt aaaaaangaa aaaaaaaggc cgggaaattt ttaccaaact 780 nggacattct ttacagatat acaatcttgc taaaacctgg gaaaaccctt cccngggtgt 840 ttaaagggga aacagtcccc cttataatgc ccggggttna gaaaancccg gattttnnaa 900 aaaggggttt tattgcccaa aactggggga accttngggg ggncccaaaa nnaacctgan 960 cccctgaagg naccgggtnn annnnntttt tgggaccttg gccgggaacc ccctttnggg 1020 ggna 1024 108 470 DNA Homo Sapien misc_feature (1)...(470) n = A,T,C or G 108 actatgacca tgattacgcc aagcttggta ccgagctcgg atccactagt aacggccgcc 60 agtgtgctgg aattcgccct ttcgagcggc cgcccgggca ggtactattt tttttttttt 120 ttttcgtgtn tttgacattc cttgaatctg ttttttattc cccttccaca gaacaggcct 180 gggactttcc aacaccctgc taaggaagtt ctgtgtccaa gtcccaccca ggctgggttg 240 tccccacctn ctncagccca cacagcccag gcagcatccg ggccagtgcc ctgcatgaca 300 nagggtcttt gttgtgtaat gnttgttccc aagttgcatt ttctaaccga atcagtgtgt 360 tttcatgaaa ctgagtgtta ctgtggacca gtaagttnct ctgttgtctt cagtggtctt 420 cctgtgtggc tcaagggttc tctgtgagag tctggatttt catttctggg 470 109 808 DNA Homo Sapien misc_feature (1)...(808) n = A,T,C or G 109 gggcctctag angcatgctc gacggccgcc atgtgatgga tatctgcaga attcgccctt 60 agcgtggtcg cggccgaggt acaagtctgc ctaagagaca gaagtgagtn ttataatcta 120 cttggccatt cctcccagca gagaagcagc aggtagatat ggcatgcact gtgcctgctg 180 ctgctgctct tgtggcgaac actcagatgt ggaaccatag agggaccttg aggagctggg 240 acatgattct ttagagaaga gaagagacgg ggagcacagc atgagaatgg ccagtcaacc 300 catttcaaat tcttttatta aagtgccccc cgaggggcct tgcacaaaga tgatggggag 360 agcagaactg ctgctccttg acagaactct gatccttaca ctttgtttgg agtgggcttg 420 gggacagtca caagccatga aacatgaatc caaaatggtc cccagatgag ccatggtgaa 480 ccaacagatg caagcaactt cttaaactgc tctattaaac actgctttat atgtgtcccc 540 atgatacaga aaagtgggat ggggccagcc attccagaaa tgaaaatcca gactctcaca 600 gagaaccctt gagccacaca ggaagaccac tgaagacaac agaggaacta ctggtccaca 660 gaaacactca gtttcatgaa aacacactga ttcgggtaga aaatgcaact tgggaacaaa 720 cattacacaa caaagaccct ctgtcatgca gggcactggc ccggatgctg ctgggctgtg 780 tgggctggaa gangtgggga caacccac 808 110 471 DNA Homo Sapien misc_feature (1)...(471) n = A,T,C or G 110 actatgacca tgattacgcc aagcttggta ccgagctcgg atccactagt aacggcccgc 60 cagtgtgctg gaattcgccc tttcgagcgg ccgcccgggc aggtacagcg acgtgatgat 120 gtagaggcgc ttcccatcca ggctgagctg gatcatctga gggcctncag ccacccgttt 180 tcccttgacc actaggggct ctggctggga ctttagttcc tcgtcctcca gcacttgcac 240 agggcctccc ttaacaatgc tgcctccgag gaagagctgt cctgtgaggc ggggtctctg 300 tgggtcagag atgtcatact gcctcaggtc cccatgcagc cagttgctga agtagaggaa 360 gcggtcgtcc agggagagca ggatgtcggt gatcaggcct ggcatttcgg gcagcagcca 420 gcccttcact ttcttggggg gcacctggat caccttctcc actgaccatg t 471 111 468 DNA Homo Sapien misc_feature (1)...(468) n = A,T,C or G 111 actatgacca tgattacgcc aagcttggta ccgagctcgg atccctagta acggccgcca 60 gtgtgctgga attcgccctt agcgtggtcg cggccgaggt acttnnttnc tttntttaca 120 tctgatttta atgcttcgtt aacttcaaaa ggaactggta gagttcanaa ggtgagctgt 180 tgttttncta aacctnttcc caggaagggg acattgacac ttgaattttt gtcacctttt 240 tcctcattag aaggaaagta naaagcctta ctgtaggatt tttaaaaaaa aatccatctc 300 accccatatt ggtcttaaat aagtatagac taattaacct aagctacctt taacaacgta 360 gaatttagat gggttcatat atgtgagaaa agcctgaata tangacaggg gtcctacttt 420 tttccccacc tctgtcgccc aggctggagt atagtggtgt gatcttng 468 112 813 DNA Homo Sapien misc_feature (1)...(813) n = A,T,C or G 112 attgggcctc tnnagcatgc tcgacggccg ccatgtgatg gatatctgca gaattcgccc 60 tttcgagcgg ccgcccgggc aggtaccatg ctgacttctt ggtatctttt anggcctaat 120 tttcccttcc ttgagattac tgtagtgtgt tccagctaat ttctatttgg aaacgagttg 180 gaacagctga aaactaggta ttattgaagg caaagcagcc tcacgtcagt tttttatcag 240 ctcatttggg aagttttnnt tttttttntn ttaattaatt agaaagtagg ctgggcacgg 300 nggctcatgc ctataatccc agcacttggg gaggccgagg atctcctctc tggtggatca 360 cttgagggca ggagttaaga gaccatcctg gccaacatga tgaaaccctg tctctactaa 420 aaatacaaaa agtagctggg cgtggtggca tactcttaca atcccagcta cttgggaggc 480 tgaggcagga gaatcacttg aacccaggaa gcagaggttg cagtgggcca agatcacacc 540 actatactcc agcctgggcg acagaggtgg ggaaaaaagt nagacccctg tcctatattc 600 aggctttgct cacatatatg aacccatcta aattctacgt tgttaaaggt agcttaggtt 660 aattagncta tacttattta agaccaatat ggggtganat ggattttttt ttaaaaatnc 720 tacagtaagg ctttctactt tccttctaat gaggaaaang gtgacaaaaa ttcaagtgtc 780 natgcccctt cctggggaag aggtttaaaa aat 813 113 506 DNA Homo Sapien misc_feature (1)...(506) n = A,T,C or G 113 nccaacttgg taccganctc ggatccctag taacggcana cattganctg atacgccaag 60 cttggtaccg agctcggatc cactagtaac ggncgccagt gtgctggaat tcgcccttcg 120 agcggccgcc cgggcaggta cgcggggcct ctggcgctac catggcgttt ggcaagagtc 180 accgggatcc ctacgcgacc tccgtgggcc acctcataga aaaggctaca tttgctggag 240 ttcagactga agattggggc cagttcatgc acatctgtga cataattaac actacccagg 300 atgggccaaa agatgcagtg aaagctttga agaaaangat ttncaaaaac tacaatcata 360 aagaaatcca acttaccttg tcacttattg acatgtgtgt gcagaactgt ggtccaagtt 420 tccagtctct gattgtgaag aaggaatttg ttaaagagaa tttagttaag ctactgaatc 480 ccagatacaa cttgccatta gacatt 506 114 813 DNA Homo Sapien misc_feature (1)...(813) n = A,T,C or G 114 gggcccntnn agctgctcga gcggccgcca gtgtgatgga tatctgcaga attcgccctt 60 agcgtggtcg cggccgaggt acaacttatt ctaaatattt tcattttctg tgttctaaat 120 agaaatatta agttgcagta aaaagagaaa aaaaggctat ttagcattac aaagaatcat 180 atttaaaggc tgcccaatgt agagtctagt gacctgttca ggacacctga aatataatta 240 aatgacaatt atcaaggttt taacaattta taattctaaa ccagaggatt ataaagaagt 300 gcaaattgac ttttacattc aactttagtt aaatgaaggc actcagtatt cttcctgaat 360 aatacattca gtttctcaca ttttatgctt tcatctattc agaattattt catagtaaaa 420 taatctactc ttatcacagc tgtgtgacga tttctaaatg taggaaggcc tgtgaaacat 480 gacactgcag ttaaattggt tggcctaagg actaagtaat ttttcttctg ctgaagtttt 540 aagtgagtat ttgttccaaa caagttctgt tgaaatctca cgctgttgtc aggaatcagt 600 gttatcctgg aactgttatt ctatttaatc ttcattatag cagaaatgtg ccaccatggc 660 tttgacatgt tggtaggtat tgtcttccag gcttcaaagc tgcacagagt ctacgtttta 720 gagagttggc acctttgatg tggtagtgag ctgatcatnc actttcttct cagtcaccat 780 cattttgagc tcctttgtgc tggtgagcat can 813 115 471 DNA Homo Sapien 115 accagctatg acctgattac gccaagcttg gtaccgagct cggatccact agtaacggcc 60 gccagtgtgc tggaattcgc ccttagcgtg gtcgcggccg aggtaccatg attttgtgtt 120 caggaaacaa agaacatgaa atattacatt cttcagaatg tttttcttgt gccattaaat 180 gaatcaagta aatgaggcaa tgaggcacaa ataaggaatt tagatttcag caatattttg 240 atccactgta gctttcagtt tctgaaactt tggaagggcc tacatacttt gtaagaattt 300 ttggcttata ttgttaataa tcaacagagc caagaaaaca tttcttagaa tgttcaaaga 360 caccacctta gccttccttc cctgcagcta taacattatt tttctaagag aaaaggcaga 420 gagtcttcac aaagccatac cagacttaaa attaccagag aacattttgg t 471 116 818 DNA Homo Sapien misc_feature (1)...(818) n = A,T,C or G 116 ttncannggg cccctagagc atgctcgacg gccgccatgt gatggatatc tgcagaattc 60 gccctttcga gcggccgccc gggcaggtac tttttttttt tttttttttt tttttttgtg 120 tgtggtcttg aactcctggc ctcaaatgat cttcctgcct cagcctccca aagtcctggg 180 attactggca tgagtcacca cacctggctc attctttttc ttaatatggc tctaaatggc 240 tttttatttt ttttgctttg gcaatttatt tctaggaaat taaataattc tttcattata 300 atcaagggaa tgaaagactt caggaggtcc atagtggagt tcaaaaccat atggagttca 360 ctattctaca agattataca ggcaataata taagtattct aaggtgtttt aggtagattt 420 atagatgtta gatttcaaaa tgggttaata agtgtttatg aatttccaag gtgtatcact 480 aacttctcaa gatgaaatca tatatagaaa ctatcaaaat tttccttgtt ctgctgtcaa 540 gaaatgaata atatacactg atataactgt aactcacatc taaagggata gtgcttgaat 600 aagctaattt acaatgagtt caaggtatta ttttaaaatt cttattgncc ttagacaata 660 attatgccaa caaatgtgaa aaatattaaa tctccttctg ntaatttttc cagttttatt 720 acccaaaagt cacacaggta atgcaagtca tgaaataaat caaatgagcc cttcctggag 780 agcctacttt atttaccttg ggaaaatgga tgacatnt 818 117 467 DNA Homo Sapien misc_feature (1)...(467) n = A,T,C or G 117 accactatga cctgattacg ccaagcttgg taccgagctc ggatccacta gtaacggccg 60 ccagtgtgct ggaattcgcc ctttcgagcg gccgcccggg caggtactac tggttttctc 120 cctggcttca cgtgtctctg tgttccccta tgctggggtg tcctcccagt gctttcaggc 180 ttcatctcct tcctaacctc tcctttctat tttttttttt ttttttgaga tggagtcttg 240 ctcagtcgcc cangctggag tgctaacctc tcctttcatg tggagatgga cagggatggc 300 aggagcactg agtgctcttg acaacaccat tgaagatgat gctgacgatc agctaccctg 360 tggagaaggc aggccaggct gggtgagagg ggagctcctt ggaagtcagg gggtctgtaa 420 ggacagcaag gatctctttg tcccaacctc cagcagcctt tatgggt 467 118 815 DNA Homo Sapien misc_feature (1)...(815) n = A,T,C or G 118 gggcctctna agcatgctcg acggccgcca tgtgatggat atctgcagaa ttcgccctta 60 gcgtggtcgc ggccgaggta cctggggtct cagggttgct ctgggcctga tcatccactc 120 agatctgtaa ggaggatttg caggatccat ttagaaagat cctcccttac ttccacaagc 180 atggcctttg gctcttaaat acctgtgctg gggttttgta attatagaaa caacaggaac 240 caaaactcat taatgttgag ctacaaacca gagggaagct tctttctcaa aacagggctc 300 aggcctagaa aaatctagtt ttctgaaatc gctagccagc aacagcactg agatggccat 360 cccagaaaca aggccaacac agaagcaccc ataaaggctg ctggaggttg ggacaaagag 420 atccttgctg tccttacaga ccccctgact tccaaggagc tcccctctca cccagcctgg 480 cctgccttct ccacagggta gctgatcgtc agcatcatct tcaatggtgt tgtcaagagc 540 actcagtgct cctgccatcc ctgtccatct ccacatgaaa ggagaggtta gcactccagc 600 ctgggcgact gagcaagact ccatctcaaa aaaaaaaaaa aaaatagaaa ggagaggtta 660 ggaaggagat gaagcctgaa agcactggga ggacacccca gcatagggga acacagagac 720 acgtgaagcc agggagaaaa ccagtagtac ctgcccggcg gccgntcgaa agggcgaatt 780 ccagcacact ggcgggccgt tactagtgga tccct 815 119 811 DNA Homo Sapien misc_feature (1)...(811) n = A,T,C or G 119 gggcctctnn agctgctcga cggccgccat gtgatggata tctgcagaat tcgcccttag 60 cgtggtcgcg gccgaggtac tctatttttt gcttgtatga ttgatgggtc tttcattatc 120 tgtgattgac attctatgag taggtgcttt tgctttgcct ataagtcgtt attatgaagg 180 aggaatggtg aataagaagg taatttagaa aagcctatat taaatatacc atgaacattg 240 aatatagcaa gatcttattc tctagttgtt atcttagttg ataaattctg tatgtgttat 300 gtgtttgtgt atacatatgt acttaatctg atcggtatct aaaagaagga aaggatggtc 360 aggaaacatt tatcataaat gtagccaagg atatcaatta gggtagacaa gaataggaca 420 aaaataggcc agagctcctg aggaggtgat atgggtccct tgatttgcag aaaatgacag 480 cctatccaag tggcccagtg tatgcctccc agtagcagtg ggcatgtaaa ctgcagcgac 540 cttattttta aaaccaaaaa cctagtatgt ggacaaagaa catgacaata tttggtacct 600 gcccgggcgg ccgctcgaaa gggcgaattc cagcacactg gcggccgtta ctagtggatc 660 cgagctcggt ccaagcttgg cgtaatcatg gtcatagctg gttcctgtgt gaaattggta 720 tcccgctcac aattnccaca cacatacgaa cccggaagca ttaaagtgta aaagcctggg 780 gtgcctaatg aagtgagcta ctcacattaa a 811 120 466 DNA Homo Sapien misc_feature (1)...(466) n = A,T,C or G 120 anttgacctg attacgccaa gcttggtacc gagctcggat ccactagtaa cggccgccag 60 tgtgctggaa ttcgcccttt cgagcggccg cccgggcagg tacccacgtt ttgctccaca 120 ctccttgacc acaggggctc ggacacaaac ccctgtcacc aggagagtca gtcagcacta 180 cttgggaggg ctaaagggaa atttggaaat aaaattccaa agtttggagt aaaaaaattc 240 aagtgttgat tttatattct ttccctttct gacacagcct aaagcgtagg gggaacatgt 300 gtttatctgt gggagataaa caagatggag tcccaaagac tttaacaaaa tattttttta 360 aaaatccact agaatagaaa atacattatt tagatatact ttatgctgag agtgagtata 420 tatgcttgtc ctatttaaac ttgtgagaaa aagtggtatc ccttng 466 121 812 DNA Homo Sapien misc_feature (1)...(812) n = A,T,C or G 121 ttgggcccnt nnagcatgct cgagcggccg ccagtgtgat ggatatctgc agaattcgcc 60 cttagcgtgg tcgcggccga ggtacaactc tccagggcac aatacgttta cagctgcctt 120 tccttcacat acttttctaa ttcagaacta ctcacaattc taagcaaatt cccattcacg 180 aagtctgtcc ataatgcgac cttctctttt tttaacatat acatcttaaa aaacaaatat 240 ataaaaaatt cttattttgc tggaatgctt tcaatttttc acattttaca tgatcatcac 300 atttatttct tatattgaaa ggcatggttt ctgttgacat gtcgtgcaaa gccaaaaaaa 360 aaaaaaaaaa aaagggctgg attgcttttc aattggtcta acacttttcc ttgtctaggc 420 tttggatttt aaagttcatg acagccccac caccagtaga aaccccaagg cttgcatttc 480 ctggtaatcg actggaaacg tcccctgttg gccatgctaa gattccttca acagggtcat 540 cctgcattta ttctccttct gccccacccc cacaatgaaa caagatagcc cccatatttc 600 taaatgtatc aagggatacc actttttctc acaagtttaa ataggacaag catatatact 660 cactctcagc ataaagtata tctaaataat gtattttcta ttctagngga tttttaaaaa 720 aatattttgg taaagtcttt ggggactcca tcttggttat cttccacaga taaaccatgt 780 tccccctacg ctttaggctg tggtcagaaa gg 812 122 467 DNA Homo Sapien 122 actatgacca tgattacgcc aagcttggta ccgagctcgg atccactagt aacggccgcc 60 agtgtgctgg aattcgccct tagcgtggtc gcggccgagg taccatgctg acttcttggt 120 atcttttaag gcctaatttt cccttccttg agattactgt agtgtgttcc agctaatttc 180 tatttggaaa cgagttggaa cagctgaaaa ctaggtatta ttgaaggcaa agcagcctca 240 cgtcagtttt ttatcagctc atttgggaag tttttttttt tttttttttt ttttaattaa 300 ttagaaagta ggctgggcac ggtggctcat gcctataatc ccagcacttg gggaggccga 360 ggatctcctc tctggtggat cacttgaggg caggagttaa gagaccatcc tggccaacat 420 gatgaaaccc tgtctctact aaaaatacaa aaagtagctg ggcgtgg 467 123 864 DNA Homo Sapien misc_feature (1)...(864) n = A,T,C or G 123 gggcctctng agcatgctcg agcggccgcc atgtgatgga tatctgcaga attcgccctt 60 tcgagcggcc gcccgggcag gtactttttt tttttttttt tcttttttta catctgattt 120 taatgcttcg ttaacttcaa aaggaactgg tagagttcag aaggtgagct gttgtttttc 180 taaacctctt cccaggaagg ggacattgac acttgaattt ttgtcacctt tttcctcatt 240 agaaggaaag tagaaagcct tactgtagga tttttaaaaa aaaaatccat ctcaccccat 300 attggtctta aataagtata gactaattaa cctaagctac ctttaacaac gtagaattta 360 gatgggttca tatatgtgag aaaaacctga atataggaca ggggtcctac ttttttcccc 420 acctctgtcg cccaggctag agtatagtgg tgtgatcttg gcccactgca acctctgctt 480 cctaggttca agtgattctc ctgcctcagc ctcccaagta gctgggattg taagagtatg 540 ccaccacgcc cagctacttt ttgnattttt agtagagaca gggtttcatc atgttggcca 600 ggatggnctc ttaactcctg ccctcaagtg gatccaccag agaaggagat cccttggnct 660 tccccaagtg cctggggatt attaggcatt gaagcccacc cgtggcccca agccctacnt 720 tttcttaaat taaatttaaa aaaaaanaan nnnnnnnnnn nnaaaaaaaa ccttttcccc 780 aaattgganc ctgggtttaa aaaaacctgg acccttnaan gggcntggnt tttggccctt 840 tnaaataaat tncccctaag gnnt 864 124 467 DNA Homo Sapien misc_feature (1)...(467) n = A,T,C or G 124 antatgacct gattacgcca agcttggtac cgagctcgga tccactagta acggccgcca 60 gtgtgctgga attcgccctt tcgagcggcc gcccgggcag gtacatgcac acacacacac 120 acacacacac acgtgtctac tgggctcctt ttggattttt tagttcaatc agaaatcacc 180 aaacagatca ataaagaggc aatgttaaat gaccgggaaa ttggtaatgt gacatcacaa 240 cactgccttt aaggtgccat atctaaatcc aggtagcact gctgctagca gaatctgttg 300 ttttaggaga caagggtggg ctgggtatgc tggctcgtgc ctataattcc agcactttga 360 gagggcaagg caggagaacc acattaggct aggagtttan gaccagcctg ggcaacatag 420 tgagatccca tctctacaaa aataaaaaaa ttagctttcc agctgct 467 125 833 DNA Homo Sapien misc_feature (1)...(833) n = A,T,C or G 125 gnnnnnnnnn ngnnttnnnn ntttaataga tgagcgtacg gngcctgtaa agcatgctcg 60 agcggccgcc atgtgatgga tatctgcaga attcgccctt agcgtggtcg cggccgaggt 120 acctgatatc gtttaacttt cctctttatc tttcttagag atacttcaca tgtgggacag 180 attatatttt ggaaagatgt ccacaacaat attgcccatc ccacattgct catcttacaa 240 tgtgatctca agactcctcc cactgagtgg gtgagaaggg acttatacca ctttcatttg 300 aatctaggca gatctgtgtg acagccttga ccaatagagt atggttaaag tgatgccccc 360 aggcatggtg gcccatacct ggaatcctgg tttttccggg aggcccaggt gggggtagag 420 gtgaggggga tgattgtttg aacacacgag tttgagacta ccctgagcaa cacaatgaga 480 ccctattttt ttttaatgat ttctgaagca gaatcacaaa tagccgtgcg tttttttctt 540 gcgcttttag gatacttact tttaaaaccc agtcaccata ttgttaggaa gcccaaacag 600 cacacataga gagacatacg gagaagccaa ccatagaggt tcctgttgac agctcantcg 660 aggtcttaac caacagtcat acttagctgc cagccatatg agtgaagggc ttncagatga 720 ttctaacgcc cagcagttgg gtccccccag cctgtaagcc ttcccagctg aggcctnaca 780 atgatggagc anagaaaagt gtccctgtcc aaattctgac ccatgataaa atg 833 126 788 DNA Homo Sapien misc_feature (1)...(788) n = A,T,C or G 126 nnnnnnntnn nnacanttga ctgataccca acttggtacc gactcggatc cactagtaac 60 ggccgccagt gtgctggaat tcgcccttag cgtggtcgcg gccgaggtac gcgggggatc 120 agagagaagc gaggttctcg ttctgaggga caggctcgag atcggctgaa gagagcgggc 180 ccaggctctg tgaggaggca agggaggtga gaaccttgct ctcagagggt gactcaagtc 240 aacacaggga acccctcttt tctacagaca cagtgggtcg caggatctga caagagtcca 300 ggttctcagg ggacagggag agcaagaggt caagagctgt gggacaccac agagcagcac 360 tgaaggagaa gacctgcctg tgggtcccca tcgcccaagt cctgcccaca ctcccacctg 420 ctaccctgat cagagtcatc atgcctcgag ctccaaagcg tcagcgctgc atgcctgaag 480 aagatcttca atcccaaagt gagacacagg gcctcgaggg tgcacaggct cccctggctg 540 tggaggagga tgcttcatca tccactttca ccagctcctc ttttccatcc tcttttcctt 600 ctccttcntt ttctnctnct nctnctgcat ctntaatacc aagcacccca naggaggttt 660 ctgctgatga tgagacaccc aaatncttcc anagtgctna anatagcctg ntncttcccc 720 cttnggncnt gctttccctt ncnttanatt naatnctgat taaggggttc cancanncca 780 aaaggaat 788 127 766 DNA Homo Sapien misc_feature (1)...(766) n = A,T,C or G 127 gggcctctna agcatgctcg acggccgcca tgtgatggat atctgcagaa ttcgcccttt 60 cgagcggccg cccgggcagg tactccaggt agttttcctg cacccaatct tgggtgagca 120 gcttcctggg ctccccataa atgaggtgct ccatcccatc atacagcccc atcatattca 180 gtgcttccca gatgacctcc tcaggggtgc agtagccctc tatgaagatt atgcttagga 240 taagtatgag aatgccagtc ttgggcatgc tctggacatc actcagcatc ccatcatagg 300 tgaggcccag ggaggtgaca aggacaaagg agtggccagt gggatccact tcctttacat 360 caatgccaaa gaccagcagc atgcactcgg aggcttcact aaacaacaaa gggaagtggt 420 cttcataatt ttttatgaca ctctccagta tttctgcctt tgtgatcggc tccttcattt 480 gatacttgaa gagcagaaac tgcaccaaat cagtcacctt ttcatctatc tcacttctgg 540 gtaaagactc actgtctggc aggacctgta gggtgcttgg actctcctcc ttttggctgc 600 tggagccctc atcagattga tctaatggaa gggaagcaac gaccganggg gaggagcagg 660 ctatctgagc actctgggga ggatttggtg tctcatcatc agcagaaacc tnctctgggg 720 tgcttgggta ttagangatg gcaggaagaa gaagangaag aggaag 766 128 779 DNA Homo Sapien misc_feature (1)...(779) n = A,T,C or G 128 gnnnnntnnn nacactantt tnngacccgn canctggtac cgactcggac cactagtaac 60 ggccgccagt gtgctggaat tcgccctttc gagcggcccg cccgggcagg tactcctcat 120 cctgcgtttg gtctccaggt gtcgcctttc tgccgtgttc ctaatatttt gattcctgtc 180 ttgaaaaaag cacctgctgc acagtaagcc cagggatgtg gcagctgcag cgggcttggc 240 tttgtgagga accgggtgtg tccacgttgg gggaacatca tacttgatac acacgttttt 300 atttgcacaa agaaaatgct atttttggag ccagaatttt catgtctgat ttatggtgat 360 tttcttaaga accagaactg ctggcagaaa gggggcaccc acacgcttag atagccgatg 420 tcttattaga gggcagtttg tggttcctga tttggaaatt aatattctcc aaacattcca 480 gtccaatgaa agttttatcc gctttcccat gtaaaaattc ttcccatgag agtgacttga 540 tcctcacaat cccgttgaag tcgtgtgtga gtcctacagt attaggttca gcattgccgt 600 ctncaagtgc tctttgtagg gaaacagttt ctggtcatga caagcttcca cttccatctg 660 atcctggcct ggcctggaaa cagagcacat gtgtttgagg atggcngtgt ttggggacag 720 gacatgancg tattgtgtgg ggctgctagg acangcgtgg tgtggtgggg gantgtccn 779 129 774 DNA Homo Sapien misc_feature (1)...(774) n = A,T,C or G 129 ttnnnantgg gcccntngag catgctcgac ggccgccatg tgatggatat ctgcagaatt 60 cgcccttagc gtggtcgcgg ccgaggtacc tgggtgggac tgggaaactg tgaaacaagt 120 agactgactt ggacactccc ccaccacacc acgcctgtcc tagcagcccc acacaatacg 180 ctcatgtcct gtccccaaac accgccatcc tcaaacacat gtgctctgtt tccaggccag 240 gccaggatca gatgggaagt ggaagcttgt catgaccaga aactgtttcc ctacaaagag 300 cacttggaga cggcaatgct gaacctaata ctgtaggact cacacacgac ttcaacggga 360 ttgtgaggat caagtcactc tcatgggaag aatttttaca tgggaaagcg gataaaactt 420 tcattggact ggaatgtttg gagaatatta atttccaaat caggaaccac aaactgccct 480 ctaataagac atcggctatc taagcgtgtg ggtgccccct ttctgccagc agttctggtt 540 cttaagaaaa tcaccataaa tcagacatga aaattctggc tccaaaaata gcattttctt 600 tgtgcaaata aaaacgtgtg tatcaagtat gatgttcccc caacgtggac acaccccggt 660 tcctnacaaa gccaagcccg ctgcagctgc cacattcctg ggcttactgt gcacangtgc 720 tttttttaag acaggatcaa atnttaggac ccngnanaan gcaacacctg gaga 774 130 803 DNA Homo Sapien misc_feature (1)...(803) n = A,T,C or G 130 ggnnnnttnn anacgnatcn gacctganta cgccaacttg gtaccgagct cggatccact 60 agtaacggcc cgccagtgtg ctggaattcg cccttagcgt ggtcgcggcc cgaggtacct 120 tggaagttat gtcattaata taggctggtt cgtcaaataa agcaaaacct tgcaatatca 180 gctagattta cactccggga cgttgcccaa aggtaggaag aaagcagagg gaaatatttc 240 agtcatcatt tccaaagtca ttatcaaaat ctgtgaggaa gtttaatctt ccaaagagtc 300 aatgtcagac atcaggcctc tgttgcctgc ttctctcgag gcactagatt aggagtcttc 360 aataagagac ttaacatgag gtatatggaa gatgaggcac cgagataagt tcatcattag 420 gtgtgagcac tgctcaccct tgctggcaag ttctccttaa gggcctgaag cacaggtgtc 480 caaagaaaag cgttaagtcc atcttaatag aatctatgtg gtatatgatg tggtcagccc 540 ccggtctgtg atcagcaaga acctacagca cagattatgc cctgcccact tcaatgaata 600 cctactctcc tncattctcc atcacttttt ttgctatcaa gactccggac cttgcccatg 660 gagaagttta gagaggaact cttgtggaga gctggtttat tttctgccct gtgcgacgag 720 tttcagcttg gccaaagaaa ggagtcaagg ttattaaaaa gcatcacaat ggtagatctt 780 ccaggcttgg ntttttttgt ttt 803 131 818 DNA Homo Sapien misc_feature (1)...(818) n = A,T,C or G 131 antgggcctc tnnagcatgc tcgacggccg ccatgtgatg gatatctgca gaattcgccc 60 ttngcccgct ttccagncgg gaaacctgtc ntgccagntg cattaatgaa tcngccaacg 120 cgcggngaga ggcggnttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct 180 gcgctcggcc gttcngctgc ggcgagcggt atcagctcac tcaaaggcgg taatacngtt 240 atccacagat caggggatan cggcaggaaa gaacatgtga ncaaaaggcc agcaaaaggc 300 caggaaccga aaaaaggccg ctttgttggc gtntnaccat aggctcnncc cccttgacna 360 gcttcacaaa aatctacgct cagntcccag gtgcnaaatc ccganaggac tntaangatt 420 cnnggnnttt ccccctgaan nctncctant gcgctctcct gtnccaacct tgccgtttac 480 cggatacctg nccgcctnna tnccttcgng aagcntggct tttnaatngg ctcacttttt 540 gggnatctaa aancggnnta ggcngnncgt tnnaaantng nntttttgcn caaaccccct 600 gtttaaactn acccatgngc attatcccgg aaacttttgg tnttngaatc caaccnggna 660 aanacacnan ttaatnngcc nttggcntga aacccacttg ggtnaaccat ggattttggc 720 ncnaccnagg gtnnttttnn nggcnggtnc ntacccggag ttctttnaaa acngggtggg 780 cncttanacc tatcnggnnt tcccctttan aaaaaaat 818 132 777 DNA Homo Sapien misc_feature (1)...(777) n = A,T,C or G 132 acnntatgac ntgantaccc aacttggtac cgactcggac cactagtaac ggccgccagt 60 gtgctggaat tcgcccttcg gcccgcccgg gcaggtacct ggaaaataac ttctttcttt 120 tcctctagat tttcgaagaa gcaaataaat caagaataga aacctatata taggaggttg 180 ggcctcctgc aaagaatgaa gcactttttg ttaaatacag gagaggctac ttggctgcac 240 taatatgtgc tttttggaat cttatagagt gtcaccaagt tgaactttgg aatggcttga 300 atcatccctg gagcatctgt gccgggcagt caggagtgag tgcaccgcct cccacccagc 360 cccattgggc ctcacaccct cttcattcct ttccccatga ggcaggcaaa cacggtcatg 420 accattttgg ggttcacttc aaccaggtct tctggcaggg catacactct tgctccaatt 480 tttcgggcca tagagatggc atattttgca ttgttgagtt tctcatcatc attcagattt 540 tctgtcttca gaaggtcata gttaatggaa cctggttgga tggcatcgat gangtccaga 600 acaggcagac ttgtacctcg gccgcgacca cgctaagggc gaattctgca gatatncatc 660 acactggcgg gccgntcgag catgcatcta ganggcccaa ttcgccctat agtgagtcgt 720 attacaattc actgggccgt cgttttacaa cgtcgtgact gggaaaaccc tgcgttn 777 133 775 DNA Homo Sapien misc_feature (1)...(775) n = A,T,C or G 133 ntgggcctct nnagcatgct cgacggccgc catgtgatgg atatctgcag aattcgccct 60 tagcgtggtc gcggccgagg tacaagtctg cctgttctgg acctcatcga tgccatccaa 120 ccaggttcca ttaactatga ccttctgaag acagaaaatc tgaatgatga tgagaaactc 180 aacaatgcaa aatatgccat ctctatggcc cgaaaaattg gagcaagagt gtatgccctg 240 ccagaagacc tggttgaagt gaaccccaaa atggtcatga ccgtgtttgc ctgcctcatg 300 gggaaaggaa tgaagagggt gtgaggccca atggggctgg gtgggaggcg gtgcactcac 360 tcctgactgc ccggcacaga tgctccaggg atgattcaag ccattccaaa gttcaacttg 420 gtgacactct ataagattcc aaaaagcaca tattagtgca gccaagtagc ctctcctgta 480 tttaacaaaa agtgcttcat tctttgcagg aggcccaacc tnctatatat aggtttctat 540 tcttgattta tttgcttctt cgaaaatcta gaggaaaaga aagaagttat tttccaggta 600 cctgcccggg cggccgaang gcgaattcca gcacactggc ggccgttact agtggatccg 660 agctcggtac caagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgntat 720 ccggtcacaa ttcccacaca tacgaacccg gaagcataaa gtgtaaagcc tgggg 775 134 772 DNA Homo Sapien misc_feature (1)...(772) n = A,T,C or G 134 acnnttgacc tgatacccag ctggtccgac tcggacccta gtaacggccg ccatgtgctg 60 gaattcgccc ttgagcggcc gccggggcag gtctataagt ctttaaattg ggtcgtgttt 120 ttagcaggta agactaattt atctcttctc cagtgaattg atgctggtgg gattcgattt 180 cacatcacaa cttatattga tagggatttc cttcccaaga gtaataaatt gtttggtttg 240 atataaactt gggggcatat tcaatatcaa ggtacttttt tttttttttt aagttttagt 300 tcagaataac attaattttg agagattgag gtaaagaacc ttaactaatg ctaaggagtt 360 tattttgatt aacataggtt attctgacca ccacctcttc cttccttaat ctccttagaa 420 tctgacagtc tcaaagctgt cacacaaatt agactaattt tgacactttg aaatgaaaac 480 ttcaaggaag aagtagccac ggacagttat gtttataatc agtaggtggc actctttcct 540 caggtagccc cccattttca catgatgtgt ttgaaggtta aatgccccaa aagtgctgag 600 tcagctataa aactaagtcc ctgaattcca tggccctttt aaatatgtaa tcattcaaga 660 ttgaaaaaaa aaattaagca ttttttgntt gnttgcttgg ttggttttga gacngagttt 720 cactcttgnt ggccaggctg gagtgcaatg gcgccatctn actcactgna ag 772 135 784 DNA Homo Sapien misc_feature (1)...(784) n = A,T,C or G 135 ntgggcctct nnagcatgct cgacggccgc catgtgatgg atatctgcag aattcgccct 60 tagcgtggtc gcggcccgag gtacttcttt tgaataattc agtattttaa aaatgcaagc 120 caggcacagt ggctcacgcc tgtaatccag cactttggaa ggccgaggtg gggggatcac 180 gaggtcagga gttcaagacc agcctggcca acatggtgaa acctcatctc tactaaaaat 240 acaaaaacta gctgggcatg gtggcgggca cctgtaaccc cagctacttg gagggctgaa 300 ggagaattgc ttgaatccgg gaggcagagg ttgcagtgag ctgagatggc gccattgcac 360 tccagcctgg ccaacaagag tgaaactccg tctcaaaaac aaacaagcaa acaaacaaaa 420 aatgcttaat tttttttttc aatcttgaat gattacatat ttaaaagggc catggaattc 480 agggacttag ttttatagct gactcagcac ttttggtggc atttaacctt caaacacatc 540 atgtgaaaat ggggggctac ctgaggaaag agtgccacct actgattata aacataactg 600 tccgtggcta cttcttcctt gaagttttca tttcaaagtg tcaaaattag tctaatttgt 660 gtgacagctt tgagactgtc agattctaag gagattaaag gaanggaaga ggtggtggtc 720 agaataacct atgttaatca aaaataaact tccttagcat taagttaang gtctttacct 780 caan 784 136 768 DNA Homo Sapien misc_feature (1)...(768) n = A,T,C or G 136 acnttgantg nacccacttg tccgactcgg atccctagta acggcgcagt gtgctggaat 60 tcgccctttg agcggccgcc gggcaggtac tttttttttt ctttttttac atctgatttt 120 aatgcttcgt taacttcaaa agggaactgg gtagagttca gaaggtgagc tgttgttttt 180 ctaaacctct tcccaggaag gagacattga cacttgaatt tttgccacct ttttcctcat 240 tagaaggaaa gtagaaagcc ttactgtagg atttttaaaa aaaaatccat ctcaccccat 300 attggtctta aataagtata gactaattaa cctaagctac ctttaacaac gtagaattta 360 gatgggttca tatatgtgag aaaaacctga atataggaca ggggtcctac ttttttcccc 420 acctctgccg cccaggctag agtatagtgg tgtgatcttg gcccactgca acctctgctt 480 cctaggttca agtgattctc ctgcctcagc ctcccaagta gctgggattg taagagtatg 540 ccaccacgcc cagctacttt ttgtattttt agtagagaca gggtttcatc atgttggcca 600 ggatggtctc ttaactcctg ccctcaagtg atccaccaga gaggagatcc tcggccttcc 660 caagtgctgg gattataggc atgagccacc gtacccagcc tactttctaa ttaattaaaa 720 aaaaannnnn nnnnaaaaaa acttnccaaa tgactgataa aaaactgc 768 137 777 DNA Homo Sapien misc_feature (1)...(777) n = A,T,C or G 137 ttgggcctct ngagcatgct cgacggccgc catgtgatgg atatctgcag aattcgccct 60 tagcgtggtc gcggccgagg taccatgctg acttcttggt atcttttaag gcctaatttt 120 cccttccttg agattactgt agtgtgttcc agctaatttc tatttggaaa cgagttggaa 180 cagctgaaaa ctaggtatta ttgaaggcaa agtagcctca cgtcagtttt ttatcagctc 240 atttgggaag tttttttttt tttttttttt ttttttaatt aattagaaag taggctgggt 300 acggtggctc atgcctataa tcccagcact tggggaggcc gaggatctcc tctctggtgg 360 atcacttgag ggcaggagtt aagagaccat cctggccaac atgatgaaac cctgtctcta 420 ctaaaaatac aaaaagtagc tgggcgtggt ggcatactct tacaatccca gctacttggg 480 aggctgaggc aggagaatca cttgaaccta ggaagcagag gttgcagtgg gccaagatca 540 caccactata ctctagcctg ggcggcagag gtggggaaaa aagtaggacc cctgtcctat 600 attcaggttt ttctcacata tatgaaccca tctaaattct acgttgttaa aggtagctta 660 ngttaattag tctatactta tttaagacca atatggggtg agatggattt ttttttaaaa 720 atcctacant aaggctttct actttccttc taatgaggaa aaaagtggca aaaattt 777 138 950 DNA Homo Sapien misc_feature (1)...(950) n = A,T,C or G 138 nnnnnnnnnn nnnnnnnnnn nttnnnnnnn nnnnnaaanc cnnnnnttna nnngnnaaac 60 cccattggna aanttaaccn ncccccaaaa gccctttngg ggtttaaccc ccgaaagcct 120 tccgggggna atccccaact ttaagttaaa acnggggccc cgggcccaag ttggttggcc 180 tttgggggaa aatttccgcc ccctttccga agccgggccc ggccccgggg gccaagggta 240 ccatgggaat ggttaccttt tggcaagaac tggtcaaacc ctggaaattt tggtattttt 300 gctttggaca ttggccctaa attaattaag tttcaaggtg gtcaggcttt acccactttt 360 tggtctggca acatgcagaa gagacagtgc cctttttagt gtatcatatc aggaatcatc 420 tcacattggt ttgtgccatt actggtgcag tgactttcag ccacttgggt aaggtggagt 480 tggccatatg tctccactgc aaaattgctg attttccttt tgtaattaat aagtgtgtgt 540 gaagattctt tgagatgagg tatatatctc actcttcatc aaactataag tttttttaag 600 taaaagaaaa tttattatga aactaaagga ataaaagaat gaccactcca taggcagaga 660 aacgtcactt taaggttttg acgtcaattg atttttgtcc aaatcaataa ttactgcaat 720 gattgaaaaa tgattattac taagtttgtt ttcattgtct caaggtctgc tgaactctgg 780 atccaggctg tgtcaacagg gtagtgtggt gcctcctgta cctcggccgc gaccacgcta 840 agggcgaatt ctgcagatat ccatcacact ggcggccgtt cgagcatgca tctagagggc 900 ccaattcgcc tatagtgagt cgtattacaa ttcactggcc cgcgttttag 950 139 779 DNA Homo Sapien misc_feature (1)...(779) n = A,T,C or G 139 ttgggcccnt agagctgctc gagcggccgc catgtgatgg atatctgcag aattcgccct 60 tagcgtggtc gcggccgagg tacaggaggc accacactac cctgttgaca cagcctggat 120 ccagagttca gcagaccttg agacaatgaa aacaaactta gtaataatca tttttcaatc 180 attgcagtaa ttattgattt ggacaaaaat caattgacgt caaaacctta aagtgacgtt 240 tctctgccta tggagtggtc attcttttat tcctttagtt tcataataaa ttttctttta 300 cttaaaaaaa cttatagttt gatgaagagt gagatatata cctcatctca aagaatcttc 360 acacacactt attaattaca aaaggaaaat cagcaatttt gcagtggaga catatggcca 420 actccacctt acccaagtgg ctgaaagtca ctgcaccagt aatggcacaa accaatgtga 480 gatgattcct gatatgatac actaaaaagg gcactgtctc ttctgcatgt tgcagacaaa 540 aagtgggtaa gctgacactg aaactaataa ttaggcaatg tcaagcaaat acaaattcag 600 gttgacagtc tgcaaagtaa catccatgta cctgcccggg cngnccgctc gaagggcgaa 660 ttccagcaca ctggcggccg ttactagtgg atccgagctc ggtaccaagc ttggcgtaat 720 catgggcata gctggttcct gtgtgaaatt ggtatncgct cacaattncc acaacatag 779 140 779 DNA Homo Sapien misc_feature (1)...(779) n = A,T,C or G 140 gcccntagag catgctcgac ggccgccagt gtgatggata tctgcagaat tcgcccttag 60 cgtggtcgcg gccgaggtac caggtgggct gacgcacatc ccctaaacat tctggatctc 120 ttactcatcg tgaaaggcag acgctctaag tctaaagtct agggtaggag tttccattct 180 ttggaaaacc aaagatggtt actcttctta atgaaactga gaagaaggta tctacagaaa 240 acactgaatt taaacaaatt atgaccttgt ttgttgaagc catcaaggac ccaagatata 300 tcaaagaaca acatctctgt attggcctac aggttcagag tgttttgagg tctgtttaag 360 cactaatagg attttaggcc agcatccagt cagaagagat agttcacaga ctcagagttg 420 gaaacagatt aaaaaaaaaa agatgtcaac atagaaaatg atgatagagt ttagttaaaa 480 aaattcacac ataaaattac agttaaaaaa attcacacat aaaatagagt gtttgcatag 540 caagacatta ttgcccttca gcctggcaga aaaacataaa ctcaggtgta tattttataa 600 taaacattgt attgaatgct aagaatgata cactgttgaa catctcctga atggtttgcc 660 ttcttgtaaa tcataccaat tgtttagaca attgaaattc caagctcttt ctcttctccc 720 atataaaaac caacagaaac anggaggctg ttagtagcaa gctcctcatg ggaaanggt 779 141 986 DNA Homo Sapien misc_feature (1)...(986) n = A,T,C or G 141 aanccnnnnn ntttatttgg gnaaacccaa ttgggnaaaa ttnaacccgn ccccccnaaa 60 ngcccttttn gggggttnaa ccccccggaa aaccctttcc ggggggaaat tccccaacct 120 ttaaagnttt aaaaacccgg gggccccggg cccccaaagt ttgggttggc cnttggggga 180 aaaatttttt ccgggccccc cnttttaaag cccggttggg gtttccggcc ngggggcccc 240 gggaaagggt tnaccctttt ttttttaact tttttnnntt tccttttttn nttccttttt 300 tttctttttt tttttctttg gtntnnnttt ttttttcaat tttttggttt ttggtttttg 360 gttatggttt ttttagaaca ggggtcccac tctgtcaccc aggctggagt gcagtggtgc 420 aatcacaggt cactgaaacc tcccacctag ctgggactag aggtgcaggc caccacacca 480 gctaatttat gtaatttttg tagagacgag tttcaccacg ttacctaggc ttgtcttgaa 540 cacctgggct caagcaatct tccagcccca gcctcccaaa gtgctgggat tacaggtata 600 aaccacaatg cccccgtttt tactctttac tgcatccttc ccatcagtat taattcctca 660 gaaatttagt acccctgtgc ttcattcagt atcagtaacc ctgcaatgat ttttacaaat 720 atctttttct agtgggtttt ttacttagag gaaagaactt tgtaatagct cttaatgttt 780 atatataaga gaagacagaa tggaaaatgt tttttgaagt caaatattgc atgatgtaaa 840 gaaaaaactt taaacttaaa tgagtanggt tgtcctgaat tacactggta actctctact 900 tctttattaa agaagttata gtaagatgcc tttggntacc tgatttcagt gtacctgccc 960 gggccggccg ntcaaaaggg cgaant 986 142 780 DNA Homo Sapien misc_feature (1)...(780) n = A,T,C or G 142 gggcccgtan agcatgctcg agcggccgcc atgtgatgga tatctgcaga attcgccctt 60 tcgagcggcc gcccgggcag gtacactgaa atcaggtaac aaaggcatct tactataact 120 tctttaataa agaagtagag agttaccagt gtaattcagg acaacctact catttaagtt 180 taaagttttt tctttacatc atgcaatatt tgacttcaaa aaacattttc cattctgtct 240 tctcttatat ataaacatta agagctatta caaagttctt tcctctaagt aaaaaaccca 300 ctagaaaaag atatttgtaa aaatcattgc agggttactg atactgaatg aagcacaggg 360 gtactaaatt tctgaggaat taatactgat gggaaggatg cagtaaagag taaaaacggg 420 ggcattgtgg tttatacctg taatcccagc actttgggag gctggggctg gaagattgct 480 tgagcccagg tgttcaagac aagcctaggt aacgtggtga aactcgtctc tacaaaaatt 540 cataaattag ctggtgtggt ggcctgcacc tctagtccca gctaggtggg aggtttcagt 600 gacctgtgat tgcaccactg cactccagcc tgggtgacag agtgggaccc tgtctaaaaa 660 aaacataaca naacanaacn naatgaaaaa aaaaacaaga aaaaagaata gaaaaagaaa 720 aaagtnaaaa gtncctcggn cgcgaccacg ctaagggcga attccagcac actgcggccn 780 143 794 DNA Homo Sapien misc_feature (1)...(794) n = A,T,C or G 143 nnnnnnnnnn nnnacnnttg actgataccc aacttggtac cgactcggac cactagtaac 60 ggccgccagt gtgctggaat tcgccctttc gagcggccgc ccgggcaggt acagaaagaa 120 gagccaggat attctttgtt ttcctaagcg tagctgtgag caacattatc tctcctactg 180 gcttctttga ggtatgagag tcatcattac atctgtgtgc tttgtcaagt tatatgtcac 240 aattccacct gtgggtagag aacaagcaca agagtcacat caactgtgtg ctgggccagg 300 gttatgtcac aatcttccct gagagcatgc accaggcaga agagtcacat cacagggttc 360 tcaaccagag atgttacaat cctctcctga aagcaggaca caggaaaaag agtaagatca 420 cctgcatgct gggctcagat atatgtcaca agactcactg tgggcaaagt ccagaaggac 480 agacagaaca gctggttgct tgacccagca atatgtcaca atcttctcta tgggcagaat 540 gcaggcagaa gtagagggct tcatcttcca ggtgatggat taaaaaaata catcccaagg 600 ctctctgtgg gaaagggctc angcagaaac tttccaaccc ctangtgttt gcttcagtga 660 tatgtcacaa ttaaccaaaa tatgcaggtt tcaagcaagt gagtnaagtc atatcaccta 720 nggtgcttgg tccanaaatc tgncacaatc tttttttttt ttttggcatg cccagcngaa 780 ttgaaaagtc ncan 794 144 782 DNA Homo Sapien misc_feature (1)...(782) n = A,T,C or G 144 cnanngggcc cntagagcat gctcgacggc cgccagtgtg atggatatct gcagaattcg 60 cccttagcgt ggtcgcggcc gaggtacaat cttggctcac tgcaacctcc acctcccggg 120 ttcaagcaat tctcctggct cagcctcctg agtgctggga ctacaggcat gcaccaccac 180 tcccacctaa ttttgtattt ttgatagaga cggggcttct ccatgttggt caggctgttc 240 tcaaactcct gacctcaggt gatttgactg tcttagcctc ccacagtgct gagcttatag 300 gcaggtgcca cgacacctgg ctggaatcat ttatttcaac atatctctgg gtccaacaac 360 atggtgatgc aactttcctg catgggccct cccacagaaa tactctaata catcttttca 420 ttcattatct tggtgatgtg acttttctat tctgcttggg cactgccaaa aaaaaaaaaa 480 aagattgtga cagatttctg gaccaagcac ctaggtgata tgactttact cacttgcctg 540 aaacctgcat attttggtta ttgtgacata tcactgaagc aaacacctag gggttggaaa 600 gtttctgcct gagcccttcc acagagagcc ttgggatgta tttttttaat ccatcacctg 660 ggagatgaaa ccctctactt ttgcctgcat tctgcccata gagaagattg tgacatattg 720 ctgggtcaag caacccagct ggtctgctgt ccttntggac tttgcccaca agtgagtttt 780 gn 782 145 780 DNA Homo Sapien misc_feature (1)...(780) n = A,T,C or G 145 annnttgacc tgatacccag cttggtaccg agctcggatc cactagtaac ggccgccagt 60 gtgctggaat tcgccctttc gagcggccgc ccgggcaggt acttttttta cttttttttt 120 cttttttttt ttggacatct gttttcactc ttaggctttt aaacaatagt tattgctttt 180 atccctctca gattctaata actgagagcg atggggctat attgaatctc tgtatgcact 240 gagaactgag ctatgaagag gatcttatta aactgctggt ctgactttat ggattgacac 300 tgttcctttc ttttattgtg aaaaaaaaaa aaaaccctga aagtcttggg aaccccctaa 360 agtcttttgg gaatcctcaa aaagcatggg aagttaagta tttagctaca taaatgttgt 420 aagatcatat cttatgtata gaagtaataa gaccatttgg aattactgga ctaattgaat 480 agttaagggt tctattcggg acaataaaat gtattttgaa agtgctgcta actattgatg 540 ctgacagtgt ttcactccta tgagtgaccc aaacatatta taaatatgtg gtaaagggaa 600 tggagcctgt ggggttgagc agaatgttgg actttttttt tnnnnnnnnn nttttttngc 660 ttnctattng atngataacg atttcnggat tncctttaaa nncncngang gtttggaaac 720 tttggactgg attctggttc ccngaaacag gttcactggg nnccggggga cacttttaan 780 146 778 DNA Homo Sapien misc_feature (1)...(778) n = A,T,C or G 146 ttgggcccnt agagcatgct cgacggccgc catgtgatgg atatctgcag aattcgccct 60 tagcgtggtc gcggccgagg tacatggagg cctggactgt aaagagacta cggaaggggc 120 agcatgtgtg ttttgcttct cagattcatt gtcactcacg ttgcataaag tcctcagttg 180 tttttaagta attgttttac tatggatata ttaaacatac agaataaaaa agggaataaa 240 catacaattt ggcaaacccc ctactgagcc tttaaaaata ttagaaggtt ggtattaaac 300 caggtaactt acggatttgg aaaaaaaaaa aaaaagaaag cattgaatat ggctgggcgg 360 ttctctgggg atccttgggc agacccagtt tgccccgatt tctcactgta gttttcaaga 420 ataactgtag gaggcggtgg gagtgcagca tcctgagata agggagacga gccagaacag 480 cgcgggcact gttccagccc ccctagaaat gggttgatct tcagtgcttc agctcagtgt 540 gtcatgcttc acccacgatg taaaagccta ggatcggagg cttccccagg gttcgtcagc 600 tgtggcacaa tagggcccgt tgcaaataag attctattcc tgtcagacag tttcgtgagt 660 ttgtggggga acactcaccc tagcttctgn tgnctcttca tgcctgtgtg ttcctaatca 720 acttttttgn gtaacttggt gttttgaaag tgtcaccagc acacaatgga acctgtcn 778 147 784 DNA Homo Sapien misc_feature (1)...(784) n = A,T,C or G 147 acnntatgac ctgattacgc caacttggta ccgactcgga ccactagtaa cggccgccag 60 tgtgctggaa ttcgcccttt cgagcggccg cccgggcagg tacttttttt tttttttttt 120 tttttttttg ggattgaatc aacatgcttt aataggaaaa gatgtatggg ctatatatgn 180 atcaatctgg ngaancctcg ntctaataaa gggtcttttt cttttctatg atacacacag 240 ncacgctgat aatatgcnaa tgaacatttt cctttatgnc tctncanata atggttattg 300 gctgaggnaa attaaattcc caccanggnt tgctgncagt attttaacac ccacattagt 360 atatgcntnc agggtcataa ccccctaaaa tccatnatgc aaccttatta atctggcttg 420 ggantccngg ttaatgcttg gatttanttc ctgattacac tncntngaaa agtgagacat 480 ttgncattcc caactttggg aaaaccaact tatattcaac cntntnaatg aaggccatct 540 tgatggnctc aacactaatt tttatgatgc aaatttatac acngattttt gtaaagggca 600 aagttttaaa agcgtattta acttgatggt ttctatcagc attaatnaaa tggncatgaa 660 taggcattaa aaacagttgc cagtgatnat ctgcatgaaa ggaaaaagaa ccctgcaaat 720 ggctattgaa nttggaaata ttggntttga natgtaagaa aatntttaga aagctcncnc 780 tgng 784 148 775 DNA Homo Sapien misc_feature (1)...(775) n = A,T,C or G 148 gggcccntan agcatgctcg acggccgcca gtgtgatgga tatctgcaga attcgccctt 60 agcgtggtcg cggccgaggt acaaagcact gtttaaaacc agtccaagat acttaatcca 120 aactgtatca tgattcttca ttagaaatct agacaccact catggtggtt tcttacactt 180 taaaaagttg aggcattttc agtgtgagca ttctgaatat ctcttacata tcaaaaacaa 240 tacttccaac tcaatagcca tttgcagggt tctttttcct tcatgcagat tatcactggc 300 aactgttttt aatgactatt catgaccatt ttatttatgc tgatagaaaa catcaagtta 360 aatacgcttt taaaactttg tcctttacaa aaatcagtgt ataaatttgc atcataaaaa 420 ttagtgttga gaccatcaag atggccttca tttatatggt tgtatattag ttggttttcc 480 cagagttggg aatggcagat gtctcacttt tctatgtagt gtaatcagga aataaatcca 540 agcactaaac aggaatccca agacagatta ataaggttgc atgatggatt ttagggggtt 600 atgaccctgg acgcatatac taatgtgggt gttaaaatac tgacagcaag ccctggtggg 660 aattaattta cctcagacaa taaacattat ctggagagac ataaaggaaa atgttcattt 720 gcatattatc agcgtggctg ggtgtatcat agaaaaagaa aaagaacctt tttan 775 149 783 DNA Homo Sapien misc_feature (1)...(783) n = A,T,C or G 149 acnntatgac ctgatacgcc aagcttggta ccgagctcgg atccactagt aacggccgcc 60 agtgtgctgg aattcgccct tagcgtggtc gcggccgagg tacccgatta aaccagagca 120 aaaactacct tctgcaggtc agggagctaa tgacatggca ttggccaaac gttcccgcag 180 tcgaactgct acagaatgtg acgttcgtat gagcaagtct aagtcagaca atcagatcag 240 tgacagagct gctttggagg ccaaagtgaa ggatcttctc acgctggcaa aaaccaaaga 300 cgtagaaatt ttacatttga gaaatgaact gcgagacatg cgtgcccagc tgggcattaa 360 tgaggatcat tctgagggtg atgaaaaatc tgagaaggaa actattatgg ctcaccagcc 420 gactgatgtg gagtccactt tattgcagtt gcaggaacag aatactgcca tccgtgaaga 480 actcaaccag ctgaaaaatg aaaacagaat gttaaaggac aggttgaatg cattgggctt 540 ttccctagag cagaggttag acaattctga aaaactgttt ggctatcagt ccctgagccc 600 agaaatcacc cctggtaacc agagcgatgg aggaggaact ctgacttctt cagtggaang 660 ctctgcccct ggctcantgg gaggatctct tgagtcagga tgaaaataca ctaatggacc 720 attagcacag tacttcatgg caatttagac agtgagtgca atgaggtcta ccagcccctt 780 ann 783 150 771 DNA Homo Sapien misc_feature (1)...(771) n = A,T,C or G 150 gggcccntan agcatgctcg acggccgcca tgtgatggat atctgcagaa ttcgcccttt 60 cgagcggccg cccgggcagg tactgtgttg gttctcttcc atctggtgta tccgttcagt 120 caggcaagcc acggacactt cactggcatt cccgctgctc cccttccggg agcgctctat 180 gctggggatg ccttccgact ctgaggagga tggtgcatcc agcgcatcat cgctcgatgt 240 gaggggctgg tagacctcac tgcactcact gtctaaattg tccatggagt tactgtgctg 300 atggtccatt agtgtatttt catcctgact caagagatcc tccactgagc caggggcaga 360 gccttccact gaagaagtca gagttcctcc tccatcgctc tggttaccag gggtgatttc 420 tgggctcagg gactgatagc caaacagttt ttcagaattg tctaacctct gctctaggga 480 aaagcccaat gcattcaacc tgtcctttaa cattctgttt tcatttttca gctggttgag 540 ttcttcacgg atggcagtat tctgttcctg caactgcaat aaagtggact ccacatcaag 600 tcggctggtg agccataata gtttccttct cagatttttc atcaccctca gaatgatcct 660 cattaatgcc cagctgggca cgcatgtctc gcagttcatt tctcaaatgt aaaatttcta 720 cgtctttggt ttttggcagc gtgagaagat ccttncttgg nctcnaagcn g 771 151 778 DNA Homo Sapien misc_feature (1)...(778) n = A,T,C or G 151 acnntatgac ctgatacgcc agcttggtac cgactcggat ccactagtaa cggccgccag 60 tgtgctggaa ttcgcccttt gagcggccgc ccgggcaggt actttttttt ttcttttttt 120 acatctgatt ttaatgcttc gttaacttca aaaggaactg gtagagttca gaaggtgagc 180 tgttgttttt ctaaacctct tcccaggaag gagacattga cacttgaatt tttgccacct 240 ttttcctcat tagaaggaaa gtagaaagcc ttactgtagg atttttaaaa aaaaatccat 300 ctcaccccat attggtctta aataagtata gactaattaa cctaagctac ctttaacaac 360 gtagaattta gatgggttca tatatgtgag aaaaacctga atataggaca ggggtcctac 420 ttttttcccc acctctgccg cccaggctag agtatagtgg tgtgatcttg gcccactgca 480 acctctgctt cctaggttca agtgattctc ctgcctcagc ctcccaagta gctgggattg 540 taagagtatg ccaccacgcc cagctacttt ttgtattttt agtagagaca gggtttcatc 600 atgttggcca ggatggtctc ttaactcctg ccctcaaagt gatccaccag agaggagatc 660 ctcggcctnc ccaagtgctg ggattatagg catgagccac cgtacccagc ctactttcta 720 attaattaaa aaaaaannnn nnnnaaaaaa aacttnccaa atgagctgat aaaaacng 778 152 772 DNA Homo Sapien misc_feature (1)...(772) n = A,T,C or G 152 gggcccntag agctgctcga cggccgccat gtgatggata tctgcagaat tcgcccttag 60 cgtggtcgcg gccgaggtac catgctgact tcttggtatc ttttaaggcc taattttccc 120 ttccttgaga ttactgtagt gtgttccagc taatttctat ttggaaacga gttggaacag 180 ctgaaaacta ggtattattg aaggcaaagt agcctcacgt cagtttttta tcagctcatt 240 tgggaagttt tttttttttt tttttttttt tttaattaat tagaaagtag gctgggtacg 300 gtggctcatg cctataatcc cagcacttgg ggaggccgag gatctcctct ctggtggatc 360 acttgagggc aggagttaag agaccatcct ggccaacatg atgaaaccct gtctctacta 420 aaaatacaaa aagtagctgg gcgtggtggc atactcttac aatcccagct acttgggagg 480 ctgaggcagg agaatcactt gaacctagga agcagaggtt gcagtgggcc aagatcacac 540 cactatactc tagcctgggc ggcagaggtg gggaaaaaag taggacccct gtcctatatt 600 caggtttttc tcacatatat gaacccatct aaattctacg ttgttaaagg tagcttaagt 660 taattagtct atacttattt aagaccaata tggggtgaga tggatttttt tttaaaaaat 720 cctacagtaa ggntttctac tttccttcta atgaggaaaa angnggcaaa at 772 153 780 DNA Homo Sapien misc_feature (1)...(780) n = A,T,C or G 153 acnntatgac ntgaatacgn ccaagcttgg taccgagctc ggatccacta gtaacggccg 60 ccagtgtgct ggaattcgcc cttagcgtgg tcgcggccga ggtacttttt tttttttttt 120 tttttttttt tttagttaaa gaatgcttta ttaatacaaa tacacacaaa ctctgaagca 180 ctaagaaatt taaatatcta tgtcacagca aacaggtggc aattcaacat ccagggtcga 240 cagaatgctt gaaggagact gcaacagatt ggattcccat ggtggagagg gcatnttcac 300 aggtgaaggg gggcccagct gaaacagctt ttcaagctct ctctcctcgt caaggatcat 360 gagaggcact ccactcaagg ggaggtgcgc aatctggtgc tcttcaggca ggtcaaaact 420 ctcaaagtct agaggattga agggaaagaa tttttctatt tctggatagg catcatctga 480 ggcaggaaca gagctttttg ctttaacagt cttctcagtc atctttttgg cagaaaagct 540 tggctgtttt tgtttgaggg gtcccttggt ctttacagac ttttctgtag ctctgttgac 600 agttcccaaa gcctttctag tagctttagg taaggctggt ggggcatcga acgttttgcc 660 aaaacgtggt gttgaaactt gagatctccc atctaangct ttgattgaan gtccagaccc 720 cagcttcagc ccatccttag caaccacacn ggtgcctggg tctncatttt ccttatnang 780 154 770 DNA Homo Sapien misc_feature (1)...(770) n = A,T,C or G 154 gncctgtnna gctgctcgag cggccgccat gtgatggata tctgcagaat tcgccctttc 60 gagcggccgc ccgggcaggt acgcggggac cgcggcctca gatgaatgcg gctgttaaga 120 cctgcaataa tccagaatgg ctactctgat ctatgttgat aaggaaaatg gagaaccagg 180 cacccgtgtg gttgctaagg atgggctgaa gctggggtct ggaccttcaa tcaaagcctt 240 agatgggaga tctcaagttt caacaccacg ttttggcaaa acgttcgatg ccccaccagc 300 cttacctaaa gctactagaa aggctttggg aactgtcaac agagctacag aaaagtctgt 360 aaagaccaag ggacccctca aacaaaaaca gccaagcttt tctgccaaaa agatgactga 420 gaagactgtt aaagcaaaaa gctctgttcc tgcctcagat gatgcctatc cagaaataga 480 aaaattcttt cccttcaatc ctctagactt tgagagtttt gacctgcctg aagagcacca 540 gattgcgcac ctccccttga gtggagtgcc tctcatgatc cttgacgagg agagagagct 600 tgaaaagctg tttcagctgg gccccccttc acctgtgaag atgccctctt caccatggga 660 atccaatctg gtgcagtctc ttcaagcatt ctgtcgaccc tggatgttga attgccacct 720 gtttgctgtg acatagatat ttaaatttct tagtgcttca gagtttgngg 770 155 767 DNA Homo Sapien misc_feature (1)...(767) n = A,T,C or G 155 acattatgac tgatacgcca gcttggtacc gactcggatc cactagtaac ggccgccagt 60 gtgctggaat tcgcccttag cgtggtcgcg gccgaggtac gcgggcccgc tggataactg 120 ccctgggaca cagcagcggg aagccgcctg cagactgaac ctcactgacc caggtggaaa 180 tcgttaggtc atttactgct aagcagccag atgaactctc cctgcaggtg gctgacgtcg 240 tcctcatcta tcaacgtgtc agcgatggct ggtatgaggg ggaacgacta cgagatggag 300 aaagaggctg gtttcctatg gaatgtgcca aggagataac atgtcaagct acaattgata 360 agaatgtgga gagaatggga cgcttgctag gactggagac caacgtgtag tctctcagat 420 ggtcttttgt tactgcaaga tttgcacgac acttaccggg ctggttggtt ctgggctagt 480 tttattgnta attttgtcac agcctattta attaaaagaa cgaaaacact tgcctttaag 540 cttgccaggt tgttctgctc tctcatgaga agagcttgga tacagtgagt ttgcacagct 600 cagtttttac ctaaccacac acttgcagac ctnctgaggt acctgcccgg gcggccgctc 660 gaaanggcga attctgcaga tatccatcac acttggcggn cgctcgaaca tgcatctaga 720 nggcccaatt cgncctatag tgagtcgtat tacaattcac tggncgc 767 156 827 DNA Homo Sapien misc_feature (1)...(827) n = A,T,C or G 156 attgggcccc tagatgcatg ctcgacggcc gccagtgtga tggatatctg cagaattcgc 60 cctttcgagc ggccgcccgg gcaggtacct caggaggtct gcaagtgtgt ggttaggtaa 120 aaactgagct gtgcaaactc actgtatcca agctcttctc atgagagagc agaacaacct 180 ggcaagctta aaggcaagtg ttttcgttct tttaattaaa taggctgtga caaaattaac 240 aataaaacta gcccagaacc aaccagcccg gtaagtgtcg tgcaaatctt gcagtaacaa 300 aagaccatct gagagactac acgttggtct ccagtcctag caagcgtccc attctctcca 360 cattcttatc aattgtagct tgacatgtta tctccttggc acattccata ggaaaccagc 420 ctctttctcc atctcgtagt cgttccccct cataccagcc attggctgac acnttgattg 480 gatgaaggcc ancttanncc nactngcagg gagaagtcaa tttgnttgnt taaccnntna 540 atggancctt accnanttnc acctggggtc aagtgagggt tcaagtctgc angcggcttc 600 ccgctgctgt ggtcccaagg gcaagttatn cagcggggcc cgcgttacct tgggccgggg 660 accaacgcct taangggccg aaatttccaa gcacacttgg ccggcccgtt acctagtggg 720 atnccgaact tcgggtaccc aaagccttgg gcgttaatca atgggtcaat aggcttggtt 780 tcctggtgtg naaaattggt aatccggttc acaanttccc cacaaca 827 157 818 DNA Homo Sapien misc_feature (1)...(818) n = A,T,C or G 157 aacactatga cctgatacgc cancttggta ccgnctcgga tccctagtaa cggccgccag 60 tgtgctggaa ttcgcccttt cgagcggccg ccgggcaggt acataatctg gaaatttatg 120 ttacaggtat gcatatttgt atatgaaaaa tattaactga gaaattactg agcttcttag 180 caaaaaatat aattatttca gagatatgat acagtttaat atctgccttc ctcaaaaagt 240 cagaaaataa aaagttttaa attgcatata ttttcatttc ttacatatgt cagaacactc 300 agaattttta ataaaatgtt ttaaaacata attataagtt gttactttta tttctatggt 360 tagtggaacc cacagggtcc tgtatctgat taaatggagg atatattagg agaatttttt 420 agaagaatga cacatgtgac ataccaccat atttgcaaga aaatataact tgatagtaga 480 gtaagttagc tgctttatat gatgaattaa aggcactagc tcttagaaaa aaaaggatta 540 aaatgctgac ttcagtaata atgtaaggag ctctgctctt taacatttcc taattaggta 600 taaactatga tggaagggaa aggtggaatg gaagtntcta cntnttacca ttggctttcn 660 ttcatgaaat tggcagnnag cctnccattt cnnnaggnct ttaatnaaaa antttttccc 720 aacttttnct tttcnaaaaa nttnttnncc nnatngnnaa ctggnggtna aaacccggct 780 tttttggggg gaaancctac ctggntnggg naaaaant 818 158 772 DNA Homo Sapien misc_feature (1)...(772) n = A,T,C or G 158 ntgggcccnt nnagcatgct cgacggccgc cagtgtgatg gatatctgca gaattcgccc 60 ttagcgtggt cgcggccgag gtacttcaac cacccctcct acaaaactct atacccttgt 120 catattaaaa ttgtatgtta tgccaggctt ccctaataca acaaaatctc tgaataaaac 180 ctattaaata tacaatttct atcaacatgc ctgccacaca tgcttaataa ttgcttagtg 240 aatacaagat taatgcatga gtgcctaagt tacttcatct agtataacaa atgacaatat 300 ctcatttgtt tcccgaagta tccttattcc attcaagctc tgaagaaagt attaatgata 360 ttcgtcctta agtaattttt tctgcattca aatctcacca ttcaaatgat tttccaacag 420 tagtttcccc aaaagcagtt tacacagtta catttgttat aatttttgaa agaaaagttg 480 ggaaaatttt attaagactc tgaatgtagc ttactgccaa ttcatgaaga aagcaatgta 540 atacgtagat acttcattcc acctttccct tcatcatagt ttataactaa ttaggaaatg 600 ttaaagagca gagctcctta cattattact gaagtcagca tttatacttt tttttctaag 660 agctagtgcc tttaattcat catataaagc agctaactta ctctactatc aagttatatt 720 ttcttgcaaa tatggtggta tgtcacatgt gtcattcttc taaaaaattc tg 772 159 1024 DNA Homo Sapien misc_feature (1)...(1024) n = A,T,C or G 159 ttgggnaaaa ttttaaaccg gcccccccaa angncccttt ttgggggntt aaaccccccg 60 gnaangcccc tttccggggg gggaaattcc ccccaaccct ttaaaggttt aaaaacccgg 120 gggccnccgg gccccccaaa ggtttgggtt tgggcccttt ggggggaaaa aattttttcc 180 gggccccccc ntttttaaag gccgggttgg ggggtttccc gggcccgggg gccccccgga 240 aaaggggttt aacccccttn aatttttttn gggtttttcc cccccaaatn gggtttccaa 300 tttttttttt tttaaaaaac ccaaaanggg aaaaaaaggg gttggcccaa aatttaaggg 360 cctttctttc aaaagggttt cctttgggaa aaaaaaacct tgggttgggg gaaaaggttt 420 ncccaaaaat ttaaacctgg gaaaaccttc tttgggnaac ccactttaaa aatttaaant 480 taaanttaaa tttaaattta aanttaagga atgggnttgg aaaaaaaaag gaatattccn 540 ttaatttggc cttaattttt taatttgntn atttgactgg tnatgnnttt acttttnaaa 600 aacntnctnn ccaaaaacca attttacntg gncnngtggg atttaccntn ttcnattacc 660 ngggagttaa cccaactnga acntttngga gggnccagtc ctccataggg acctccntca 720 nttntgatnc caactgcaag ttcagggaaa ttctcacatc ccccttgggc natatatctc 780 tttaaaagcn cctcacagca ctcactgaan tctattatat tatagatang gtntattatg 840 ggaaangggt nacanntcaa natnncccaa cgcggggana cacanngngc agngcccgat 900 gatnttccna nacacagant ttggtgttct ctggagncgt ttcccccnta gnaaaatgtt 960 gacacntgga cagagttttt acccccaggg gaacgtnaat caatctttgg aagtttcaaa 1020 tcag 1024 160 771 DNA Homo Sapien misc_feature (1)...(771) n = A,T,C or G 160 gggcctctnn agcatgctcg agcggccgcc agtgtgatgg atatctgcag aattcgccct 60 ttcgagcggc cgcccgggca ggtactgtaa gttattttct tccttatctc ccaatgacac 120 tgttttctac atgaaaaata ccattttggc tttatcaaca tgttattaat tcataatatg 180 agagatctat cagcactatt tgtaaaaata ttcaattaaa aaaattaaga tgatttatag 240 ttgtgtggta aagaatttga ccttacccaa aggaggtcag gcttttgccc tcagccttaa 300 ggagataatc ttgtcatacc caataaaagt gttattttaa agtgaggctg actacacctg 360 ataatccagc ttgagggaca gttatgccag tttgaccaac tagatgattt agggagcttt 420 ctctcccaac ttcaaagctg tgatgaatca aacaggtaat taatcgatca tgcttatgta 480 atgaagcctt gattgaaact tcaaagattg attgacgttc cttggttggt aatactctgt 540 catgtgtcaa ttctagaagg gtaatacgtc ctgaggataa cagaagctct gtgtttggaa 600 tcatcctgga ctctgcactt tgnttctcct gctttggctg attttgatct gtaaccttta 660 cctataataa accataacta taatataata gatttcagtg agtgctgtga ngctttctag 720 tgatttattg aacctaaggg tggatgtgag aatttnctga acttgcagtt g 771 161 771 DNA Homo Sapien misc_feature (1)...(771) n = A,T,C or G 161 acncttgacc tgatcgccag cttggtaccg actcggaccc tagtaacggc cgccagtgtg 60 ctggaattcg cccttagcgt ggtcgcggcc cgaggtacag aatttattat gaaatagctt 120 aatggcaagt ggtaatttag aagaattaag ttatcagata ggagatatat taaaatattt 180 aaaaattgga tatattcttg aagccctttt acacaagtaa tttctataat ttgattgtaa 240 tgaaagtata atataccttg ttactattat cagattaatt tttgaaagta gaattcctta 300 atcaagccaa ggttatgctg ctttataaga aattaatcag gtagtttaac actagagctc 360 attagccaac ctgtatgtag cacaaaataa tcatctctga taaataccta taaatatatt 420 ttattcatac ttttaaatat tttacaattc aaataaaaac cttatatgta gacaatctgg 480 gctaaatttc catgtatgtt ttgaaaaata atgttagcat gaatagattc atatttaaat 540 atgattttaa atactcttaa tagaggagac ataagaaata tttacataaa agctaagtag 600 catgatacag ctcatggtta ttttcctcat aggaaaacaa ttacttgatt tttttttgca 660 taggattaaa gactgagtat cttttctaca ttcttttaac tttctaangg gcacttctca 720 aaacacagac caggtagtaa atctncactg ntctaaggtc tcaccccact t 771 162 768 DNA Homo Sapien misc_feature (1)...(768) n = A,T,C or G 162 gggcccctnn agctgctcgn cggccgccag tgtgatggat atctgcagaa ttcgccctta 60 gcggccgccc gggcaggtac tacaaaaaca gaataatttt gaagttttag aataaatgta 120 atatatttac tataattcta aatgtttaaa tgcttttcta aaaatgcaaa actatgatgt 180 ttagttgctt tattttacct ctatgtgatt atttttctta attgttattt tttataatca 240 ttatttttct gaaccattct tctggcctca gaagtaggac tgaattctac tattgctagg 300 tgtgagaaag tggtggtgag aaccttagag cagtggagat ttactacctg gtctgtgttt 360 tgagaagtgc cccttagaaa gttaaaagaa tgtagaaaag atactcagtc ttaatcctat 420 gcaaaaaaaa atcaagtaat tgttttccta tgaggaaaat aaccatgagc tgtatcatgc 480 tacttagctt ttatgtaaat atttcttatg tctcctctat taagagtatt taaaatcata 540 tttaaatatg aatctattca tgctaacatt atttttcaaa acatacatgg aaatttagcc 600 cagattgtct acatataagg tttttatttg aattgtaaaa tatttaaaag tatgaataaa 660 atatatttat aggtatttat cagagatgat tattttgtgc tacatacagg ttgggctaat 720 gagctctagt ggtaaactac ctgataattt cttataaagc agcatacc 768 163 776 DNA Homo Sapien misc_feature (1)...(776) n = A,T,C or G 163 nantatgacc tgatacgcca acttggtacc gactcggatc cactagtaac ggccgccagt 60 gtgctggaat tcgcccttag cgtggtcgcg gccgaggtac tcttccgcag agggaaggct 120 gtagaagtct ttgcaagctt catacagaga aatacaaaag gtgtgatgcc attaactggt 180 cctttctaaa gcattaggaa tttagtgaaa ctctcaaaca caaaactgaa aagccatttg 240 aacaaatctc atatacttgt agataagctt ttttttattt aaagcataca aattcaaatc 300 tttcaagcag aaaattcagt caagtgagat ccattggtgg tttgagttca aagtcagtga 360 gcaaatggaa atcattgcgg catctctctc atttccctag tggacattag accactcaaa 420 atgtgtcaca taatttacag ccccttggta gtaattgaat atacacgttg agagtgcact 480 ggcagaacac ttaagaaaga ttgaatgcag gaggaccagc ttacgttatt tttggctcta 540 ctctggtttt tgcttttaat gttttttctt gagattaatt tcaattgggt tgttccatcc 600 tattcaaaca aatgctttga gagaagagat gaacagcagc atcaaataaa attgtgatat 660 ttagtttnag agacatcang tgttgtaatc aaataagaca gaanggccaa gttaaaatct 720 gtgattngca taaatgaatt taactgttag aatagcanaa ttgagaggtn gattan 776 164 773 DNA Homo Sapien misc_feature (1)...(773) n = A,T,C or G 164 cgggcctcta gatgctgctc gacggccgcc atgtgatgga tatctgcaga attcgccctt 60 tcgagcgccg cccgggcagg tacacagtgg ataccacata ctcgctctga ggaagaagga 120 ggaggagaaa gaggagaagg aaggaaattt tcaaatgaca atttctatca ggactcattt 180 tcctattata agttcagaat acttggacgt ctttataaaa tcaagttgaa atctctacta 240 ttttgatctg tattctctta aatattaaag gttataccta gggagattcc atgttgactg 300 gcaaacaaag cataccattt taagaataac tcttcataaa atatgtgtct aagaattaaa 360 agtgtctagt aacagataca caaaagagag atttagaata attaatattt aaagacagat 420 aattttaatg tttcacactt ttaactacaa aattctttgt tttcctaaat attagcaaaa 480 atgttatata ttaaaataaa tcttgaaaat ctcaccctac atttagataa tagttcaaaa 540 gtcatattgc taatctacct ctcaattctg ctattcttac agcttaaatt catttatggc 600 aaatcacaga ttttactttg tccttctgtc ttatttgatt acaacacctg atgtctctga 660 aactaaatat ccaatttatt tgatgctgct gttcatctct tctctcaaag cattngtttg 720 aatangatgg aacaacccaa ttgaaattaa tctcaaggaa aaacattaaa ant 773 165 783 DNA Homo Sapien misc_feature (1)...(783) n = A,T,C or G 165 tnnnnnacac tatgacctga ttacgccanc ttggtaccga ctcggatcca ctagtaacgg 60 ccgccagtgt gctggaattc gcccttagcg tggtcgcggc cgaggtacag taggaaaata 120 agaataacaa cgggcaaaat ctttttagaa catttatgct ttatctgttt tagcttctaa 180 aacaatcctg aaggatgaat aattatcatg agtatagcag aatttaattt tccctgttgc 240 tccaaaattt taatgaaaac tttacggttg agagaaatag gtaaataaaa aaacttccta 300 aaattctaaa gacaattgtt gaataaaatt taagtgaatg agtttgtgct tcatatttaa 360 cttttaactt tccaataggc tttattaaat ggaaaactga aatttacaaa gtcttagagt 420 agaagcattt ttatcctggc tagggattct ctaagagaac cagtagcacc aagatgcact 480 ggaacagtgc aacgagagag ttcatgcctt agggtttaga agcatacaag caaagggaat 540 ggtgcccact tcttactaga aaaatttcac aggctggagt ctgggcggag gagcctggga 600 tgacagtaga agtgtgcagg aagcactaag tctagcctgt acctgcccgg gcggccgctc 660 gaaaggcgaa ttctgcagat atncatcaca ctggccggcc gntcgagcat gcatntagag 720 ggcccaattc gcctatagtg ancgtattac aattcactgg ccgcgtttta caacgtnnng 780 cnn 783 166 775 DNA Homo Sapien misc_feature (1)...(775) n = A,T,C or G 166 attgggcctc tnnagcatgc tcgagcggcc gccagtgtga tggatatctg cagaattcgc 60 ccttcgagcg gccgcccggg caggtacagg ctagacttag tgcttcctgc acacttctac 120 tgtcatccca ggctcctccg cccagactcc agcctgtgaa atttttctag taagaagtgg 180 gcaccattcc ctttgcttgt atgcttctaa accctaaggc atgaactctc tcgttgcact 240 gttccagtgc atcttggtgc tactggttct cttagagaat ccctagccag gataaaaatg 300 cttctactct aagactttgt aaatttcagt tttccattta ataaagccta ttggaaagtt 360 aaaagttaaa tatgaagcac aaactcattc acttaaattt tattcaacaa ttgtctttag 420 aattttagga agttttttta tttacctatt tctctcaacc gtaaagtttt cattaaaatt 480 ttggagcaac agggaaaatt aaattctgct atactcatga taattattca tccttcagga 540 ttgttttaga agctaaaaca gataaagcat aaatgttcta aaaagatttt gcccgttgtt 600 attcttattt tcctactgna cctcggccgc gaccacgcta agggcgaatt ccagcacact 660 ggcggccgtt actagtggat ccgagctcgg taccaanctt ggcgtaatca tggtcatagc 720 tggttcctgt gtgaaantgt atccgntcac aattcacaca acatacganc cggag 775 167 797 DNA Homo Sapien misc_feature (1)...(797) n = A,T,C or G 167 ttgnaacnat tntgacctga ttacgccaac ttggtaccga gctcggatcc actagtaacg 60 gccgccagtg tgctggaatt cgcccttagc gtggtcgcgg ccgaggtact ttcagaaggt 120 aaatcagtag atcacccatg tgtatctgca ccttctcaac tgagagaaga accacagttg 180 aaacctgctt ttatcatttt caagatggtt atttgtagaa ggcgaggaac caattatgct 240 tgtattcata agtattactc taaatgtttt gtttttgtaa ttctgactaa gaccttttaa 300 ccatggttag ttgctagtac ccttccttgt ccgaaggagc tgaccagtat tgatgagaga 360 gtccaggcag ctcctgaagt tcagctggta gtttgttctc tgaacatttg gtctcttgaa 420 ggcacagtat atctggggct tcttccttta cccaatctaa tcctttcttc ttaatccagg 480 ctcgaagccc atncacattc caagagcaga tcttgagtgt ggcaggtttg ccactgggtg 540 aggttttctg atctgggggg tcctcataca gggctggggc cctntcctgc tgcctctttg 600 tcattttctt tgcgggccgt cttactcttc ttggcctctg gcttctgtcc tgagctcatc 660 cccgtctttc ggccaccngt tccccttttt tacacgcctt cggcatttcc cgttaccgaa 720 cgccctttgg gcagctgtac ctgccccngg cggccgttcg aaaaggccna attcttgcag 780 aatttccatc ncaccnn 797 168 780 DNA Homo Sapien misc_feature (1)...(780) n = A,T,C or G 168 acantatgac ctgatacgcc aacttggtac cgactcggat ccactagtaa cggccgccag 60 tgtgctggaa ttcgccctta gcgtggtcgc ggccgaggta ctccggtcgg tgtcagcagc 120 acgcggcatt gaacattgca atgtggagcc caaaccacag aaaatggggt gaaattggcc 180 aactttctat taacttatgt tggcaatttt gccaccaaca gtaagctggc ccttctaata 240 aaagaaaatt gaaaggtttc tcactaaacg gaattaagta gtggagtcaa gagactccca 300 ggcctcagcg tacctgcccg ggcggccgct cgaaagggcg aattctgcag atatccatca 360 cactggcggc cgctcgagca tgcatctaga gggcccaatt cgccctatag tgagtcgtat 420 tacaattcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg cgttacccaa 480 cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga agaggcccgc 540 accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatggacgcg ccctgtaacg 600 gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gacccgtaca cttgccagcg 660 ccctancgcc cgctnctttc gctttcttcc ctttctttct tngcacgttc gccggctttt 720 cccgtcaagc tctaaatcgg gggctccttt tanggttccg atttantgct ttacngnacn 780 169 771 DNA Homo Sapien misc_feature (1)...(771) n = A,T,C or G 169 gggccnctng agcatgctcg acggccgcca tgtgatggat atctgcagaa ttcgcccttt 60 cgagcggccg cccgggcagg tacgctgagg cctgggagtc tcttgactcc actacttaat 120 tccgtttagt gagaaacctt tcaattttct tttattagaa gggccagctt actgttggtg 180 gcaaaattgc caacataagt taatagaaag ttggccaatt tcaccccatt ttctgtggtt 240 tgggctccac attgcaatgt tcaatgccgc gtgctgctga caccgaccgg agtacctcgg 300 ccgcgaccac gctaagggcg aattccagca cactggcggc cgttactagt ggatccgagc 360 tcggtaccaa gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg 420 ctcacaattc cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa 480 tgagtgagct aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac 540 ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt 600 gggcgctctt ccgcttnctc gctcactgac tcgctgcgct cggtcgttcn gctgcggcga 660 gcggtatcaa gctactcaaa ggcngtaata ccgntatcca cagaatcagg ggataacgca 720 ggaaagaaca ttgtgagcaa aaggcancaa aagggcagga accgtaaaaa n 771 170 777 DNA Homo Sapien misc_feature (1)...(777) n = A,T,C or G 170 acacttgacc tgatacgcca acttggtacc gagctcggac cactagtaac ggccgccagt 60 gtgctggaat tcgcccttag cgtggtcgcg gccgaggtac acagaatagc tgagcagttc 120 acttcaggga tcaggtcatc tctgctcctc ctagtttcac catgttctgg caataaaaaa 180 cacatattat atcctggttt tctctatcct tgcattacta aggtgactgt ctctctttat 240 acatccttgt atggttctcc cagtattagc aagattgtat atctgtaaag aatgtccagt 300 tttgtaaata tttccctgcc tttttttttc tttttttaca tctgatttta atgcttcgtt 360 aacttcaaaa ggaactggta gagttcagaa ggtgagctgt tgtttttcta aacctcttcc 420 caggaagggg acattgacac ttgaattttt gtcacctttt tcctcattag aaggaaagta 480 gaaagcctta ctgtaggatt tttaaaaaaa aatccatctc accccatatt ggtcttaaat 540 aagtatagac taattaacct aagctacctt taacaacgta gaatttagat gggttcatat 600 atgtgagaaa aacctgaata taggacaggg gtcctacttt tttccccacc tctgtcgccc 660 aggctagagt atagtggtgt gatcttggcc cactgnaacc tctgcttcct anggtcaagt 720 gattcttcct gcctcacctt ccaagtagct gggattggaa gaatatgccn ccccccg 777 171 782 DNA Homo Sapien misc_feature (1)...(782) n = A,T,C or G 171 nngggcccnt agagcatgct cgacggccgc cagtgtgatg gatatctgca gaattcgccc 60 tttcgagcgg ccgcccgggc aggtactttt tttttttttt tttttttttt tttaattaat 120 tagaaagtag gctgggcacg gtggctcatg cctataatcc cagcacttgg ggaggccgag 180 gatctcctct ctggtggatc acttgagggc aggagttaag agaccatcct ggccaacatg 240 atgaaaccct gtctctacta aaaatacaaa aagtagctgg gcgtggtggc atactcttac 300 aatcccagct acttgggagg ctgaggcagg agaatcactt gaacctagga agcagaggtt 360 gcagtgggcc aagatcacac cactatactc tagcctgggc gacagaggtg gggaaaaaag 420 taggacccct gtcctatatt caggtttttc tcacatatat gaacccatct aaattctacg 480 ttgttaaagg tagcttaggt taattagtct atacttattt aagaccaata tggggtgaga 540 tggatttttt tttaaaaatc ctacagtaag gctttctact ttccttctaa tgaggaaaaa 600 ggtgacaaaa attcaagtgt caatgtcccc ttcctgggaa gaggtttaga aaaacaacag 660 ctcaccttct gaactctacc agttcctttt tgaaagttaa ccgaagcatt aaaatcagat 720 gttaaaaaag aaaaaaaaaa ggcngggaaa atatttacaa aactgggaca ttctttacag 780 an 782 172 773 DNA Homo Sapien misc_feature (1)...(773) n = A,T,C or G 172 canttgacct gatacgccaa cttggtaccg actcggacca ctagtaacgg ccgccagtgt 60 gctggaattc gccctttcga gcggccgccc gggcaggtac catcctgtgg ctccttaagg 120 aggcttctct ctttaattct ccatgaggca tccagggtgg tctgggctat gggaagaacc 180 cttcaacttg ggagtagaca ggtgctccaa ttcatagtgc ccattctcag aggccttgtg 240 tgtgagtttc tccttcatgc cttccttctg gctcttcttg tgctccataa tctgctggag 300 ctggtgccca gcatagtctg gcttggtggt cagcgggcca gccggcacag ctacaccaag 360 gacatctgac accatgtagg ggcgcagcca gcccaccaag ggagtgcttc cggggctgta 420 gtgggtctgt ttgtggtaga agagaagtcc atctacctca aaagggaaat ccatagatag 480 cacatcacac aggctttcgg gagtgcaagg gaagttcttt agccccacaa atttaaaagg 540 attaagcttg gttttctctc ccagtccttc ttcttctggt aactttgaat gcatccagta 600 gaatcggaaa tcaagtctgg caatcataaa aagggtgtcc ccgccagcac atcacattca 660 gaacgtagta ggtctggttt acctcattgt aaatgcaatc tagaatggtg taagcttttg 720 ctgntgaagt ttccctgtgc ctctggcaga atgaagaaan ctgttgacac aac 773 173 772 DNA Homo Sapien misc_feature (1)...(772) n = A,T,C or G 173 ntgggcctct nnagctgctc gacggccgcc atgtgatgga tatctgcaga attcgccctt 60 agcgtggtcg cggccgaggt acagttcctt ggagcagagt gagcgccgcc ggaggttact 120 ggaactgcag aaatccaagc ggctggatta tgtgaaccat gccagaagac tggctgaaga 180 tgactggaca gggatggaga gtgaggaaga aaaataagaa agatgatgaa gaaatggaca 240 ttgacactgt caagaagtta ccaaaacact atgctaatca attgatgctt tctgagtggt 300 taattgacgt tccttcagat ttggggcagg aatggattgt ggtcgtgtgc cctgttggaa 360 aaagagccct tatcgtggcc tccaggggtt ctaccagtgc ctacaccaag agtggctact 420 gtgtcaacag gttttcttca cttctgccag gaggcaacag gcgaaactca acagcaaaag 480 actacaccat tctagattgc atttacaatg aggtaaacca gacctactac gttctggatg 540 tgatgtgctg gcggggacac cctttttatg attgccagac tgatttccga ttctactgga 600 tgcattcaaa gttaccagaa gaagaaggac tgggagagaa aaccaagctt aatcctttta 660 aatttgtggg gctaaagaac ttcccttgca ctcccgaaag cctgtgtgat gtgctatcta 720 tggatttcct tttgaggtag atggacttct cttctaccac aaacagaccc ac 772 174 780 DNA Homo Sapien misc_feature (1)...(780) n = A,T,C or G 174 acactatgac ctgatacgcc aagcttggta ccgagctcgg atccactagt aacggccgcc 60 agtgtgctgg aattcgccct tagcgtggtc gcggccgagg tacaaaaata catttttcca 120 catacaaaag agagaaaaaa acaaagacat gtggcgggtg gcgaggggag gcccaatccc 180 aacaccctac aaggttccat ggaatggaga aggaacaaaa aaatccccaa ttattttggg 240 gtaagatgtg ccccagaaaa ggtgaaatct atgcaataaa acccaggttt tcttcaaatc 300 tagcatctag gatttctatc agagtttcaa ataatcagaa tttctatcag aatttctacc 360 ctgaggtgac acctactaac tgtaggttct ttcattaaaa atgaagacat ctttcaccag 420 aatgtatcaa gctataaaac tggcttcaga gcctacactt agccagagtg gaaaaaaaat 480 agtgcatatt ttcgacagca attttgaatt gatgcttgag gtctcaatcc accagcaccc 540 agatatcatg ttacctccct cagttgaata caagttaaaa tgatgatctt atcgagatct 600 caatagagca cagtgccctt catgtttcgg gtaagaaggt gggaggagga atgaagccgg 660 gtattacacc cagcccaatg acagcttaag ccttaacatg cnggcatctt acaatgacca 720 taaacaaggg angggccaag canggctngc gatcattact ttgcgcacag aatgccatgt 780 175 771 DNA Homo Sapien misc_feature (1)...(771) n = A,T,C or G 175 gggcctctag agcatgctcg agcggccgcc atgtgatgga tatctgcaga attcgccctt 60 tcgagcggcc gccgggcagg tactaaaaca gctttgctta tgttggccag gggaaaacat 120 ggcattctgt gcgcaaagct aatgatcgcc agccctgcct tggcccctcc cttgtttatg 180 gtcattgtaa gatgcccgca tgttaaggct taagctgtca ctgggctggg tgtaataccc 240 gcttcattcc tcctcccacc ctcttacccg aaacatgaag ggcactgtgc tctattgaga 300 tctcgataag atcatcattt taacttgtat tcaactgagg gaggtaacat gatatctggg 360 tgctggtgga ttgagacctc aagcatcaat tcaaaattgc tgtcgaaaat atgcactatt 420 ttttttccac tctggctaag tgtaggctct gaagccagtt ttatagcttg atacattctg 480 gtgaaagatg tcttcatttt taatgaaaga acctacagtt agtaggtgtc acctcagggt 540 agaaattctg atagaaattc tgattatttg aaactctgat agaaatccta gatgctagat 600 ttgaagaaaa cctgggtttt attgcataga tttcaccttt tctggggcac atcttacccc 660 aaaataattg gggatttttt tgntccttct ccattccatg gaaccttgta gggtgtttgg 720 gattgggcct tccctngcca cccgccacat gtctttggtt ttttctctct t 771 176 773 DNA Homo Sapien misc_feature (1)...(773) n = A,T,C or G 176 atngggcctc tagagcatgc tcgagcggcc gccatgtgat ggatatctgc agaattcgcc 60 cttagcgtgg tcgcggccga ggtactcatg tatttttttt tttttccaga tctctttccc 120 caagttgcta ttgtaagagt attctgctgc gtgtggatgc agttatacac attaaagcag 180 atctggagtc tgaagtagct ataaagcagc tataaaacag aaatacatgc atagctgcag 240 aaaccatgat aggtagagga cttttctttt ggttttgttt tgttttgttt tgttttgttt 300 ttggttttac agagaagaga tttttattac aaagaaaaaa attccagtga attgtgcaga 360 aatgctggtt tttacaccat cctaaagaaa aactttacaa gggtgttttg gagtagaaaa 420 aaggttataa agttggaatc ttaaattgta aaattaacca ttgagtgtca aagttctaaa 480 agcagaactc attttgtgca atgaacataa ggaaagacta ctgtataggt tttttttttc 540 tccttttaaa tgaagaaaag ctttgcttaa gggttgcata cttttattgg agtaaatctg 600 aatgatccta ctcctttgga gtaaaactag tgcttaccag tttccaattg tatttagctt 660 ctggttggaa tttgaaaaaa aaagaaaaaa agaaaaagaa aacctaaata aaataggtga 720 aagttccctg actattcagg tgaatacnca aaaanaaaan nnnnnnaann nnt 773 177 772 DNA Homo Sapien misc_feature (1)...(772) n = A,T,C or G 177 acattngacc tgatacgcca gcttggtacc gagctcggat ccactagtaa cggccgccag 60 tgtgctggaa ttcgccctta gcgtggtcgc ggccgaggta cagtaggaaa ataagaataa 120 caacgggcaa aatcttttta gaacatttat gctttatctg ttttagcttc taaaacaatc 180 ctgaaggatg aataattatc atgagtatag cagaatttaa ttttccctgt tgctccaaaa 240 ttttaatgaa aactttacgg ttgagagaaa taggtaaata aaaaaacttc ctaaaattct 300 aaagacaatt gttgaataaa atttaagtga atgagtttgt gcttcatatt taacttttaa 360 ctttccaata ggctttatta aatggaaaac tgaaatttac aaagtcttag agtagaagca 420 tttttatcct ggctagggat tctctaagag aaccagtagc accaagatgc actggaacag 480 tgcaacgaga gagttcatgc cttanggttt agaagcatac aagcaaaggg aatggtgccc 540 acttcttact agaaaaattt cacaggctgg agtctgggcg gaggagcctg ggatgacagt 600 agaagtgtgc aggaagcact aagtctagcc tgtacctgcc cgggcggncg ctcgaagggc 660 gaattctgca gatatccatc acactggcgg ccgctcgagc atgctctana gggcccaatt 720 cgccctatag tgagtcggat tacanttnaa tggccgncgt tttacaacgt cc 772 178 770 DNA Homo Sapien misc_feature (1)...(770) n = A,T,C or G 178 attgggcccc tnnagcatgc tcgngcggcc gccagtgtga tggatatctg cagaattcgc 60 ccttcgagcg gccgcccggg caggtacagg ctagacttag tgcttcctgc acacttctac 120 tgtcatccca ggctcctccg cccagactcc agcctgtgaa atttttctag taagaagtgg 180 gcaccattcc ctttgcttgt atgcttctaa accctaaggc atgaactctc tcgttgcact 240 gttccagtgc atcttggtgc tactggttct cttagagaat ccctagccag gataaaaatg 300 cttctactct aagactttgt aaatttcagt tttccattta ataaagccta ttggaaagtt 360 aaaagttaaa tatgaagcac aaactcattc acttaaattt tattcaacaa ttgtctttag 420 aattttagga agttttttta tttacctatt tctctcaacc gtaaagtttt cattaaaatt 480 ttggagcaac agggaaaatt aaattctgct atactcatga taattattca tccttcanga 540 ttgttttaga agctaaaaca gataaagcat aaatgttcta aaaagatttt gcccgttggt 600 attcttattt tcctactgta cctcggccgn gaccacgcta agggcgaatt ccagcacact 660 ggcggccgnt actagtggat ccgagctcgg tacccaanct tggcgtaatc atggncatag 720 ctgttcctgn gngaaatngn natncgntna caattnccac acatacnann 770 179 502 DNA Homo Sapien misc_feature (1)...(502) n = A,T,C or G 179 cnnnttgacn tgattcgcca acttggtacc gagctcggat ccctagtaac ggccgccagt 60 gtgctggaat tcgcccttag cgtggtcgcg gccgaggtac ctggccccca acttctcgaa 120 taaaatgaaa ctatgattct tggcctcact cactaccatg tgacattgat caaatcactt 180 cacctctcca aacctcagag tctttatctg taagatggaa aaagtaacac ctacttcagg 240 ggctgtcatg aggattaaat aaatgtgccc agcaggtagt aagtatacaa cacaaagcat 300 ctaatggttc attcatacat ttgcttattt tgcaattatt ggccacctgc caatgttggg 360 cactgttcta ggcacagggg atacagcaag ggcaaacacc taactactgg tggagggaag 420 acgataaaca aatacgtaaa gatttgtgcc aggtagtgat aaaagcaaag aatgactcat 480 ggagagggtc agctggggag ac 502 180 823 DNA Homo Sapien misc_feature (1)...(823) n = A,T,C or G 180 gggccttnna gcatgctcga cggccgccat gtgatggata tctgcagaat tcgccctttc 60 gagcggccgc ccgggcaggt actgcgtggt ctccccagct gaccctctcc atgagtcatt 120 ctttgctttt atcactacct ggcacaaatc tttacgtatt tgtttatcgt cttccctcca 180 ccagtagtta ggtgtttgcc cttgctgtat cccctgtgcc tagaacagtg cccaacattg 240 gcaggtggcc aataattgca aaataagcaa atgtatgaat gaaccattag atgctttgtg 300 ttgtatactt actacctgct gggcacattt atttaatcct catgacagcc cctgaagtag 360 gtgttacttt ttccatctta cagataaaga ctctgaggtt tggagaggtg aagtgatttg 420 atcaatgtca catggtagtg agtgaggcca agaatcatag tttcatttta ttcgagaagt 480 tgggggccag gtacctcggc cgcgaccacg ctaagggcga attccagcac actggcggcc 540 gttactagtg gatccgagct cggtaccaag cttggcgtaa tcatggtcat agctgtttcc 600 tgtgtgaaat tgttatccgc tcacaattcc acacaacata cgagccggaa gcataaagtg 660 taaagcctgg ggtgcctaat gagtgagcta actcacatta attgcgttgc gctcactgcc 720 cgcttttcag tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc aacgcgccgg 780 gaaaagcngn ttgcgtattg gggcgctctt ncgctttctt gcn 823 181 501 DNA Homo Sapien misc_feature (1)...(501) n = A,T,C or G 181 cantatgacn tgattcgcca acttggtacc ngctcggatc cctagtaacg gncgccattg 60 tnctggaatn cgnccttagc gtggtcgcgg ccgaggtact ttcttcnttt nctnnaattt 120 tccataacct agtgccngnt tgatnccctc acatggntgg ttcacatncn cngtacagan 180 gcncggncac catggganag ggcagcactc ntnccttctn angggatctt ggcctaangg 240 tgtacnaagg gagangatgg antntcttct gncctcncta nggcctaggg aacccagnag 300 canatcccac nacnccttcn atntttnagc caaggagaag ccccttggtg acnttnagtt 360 ccaaccatta tacncagtgn gagaatggat nntcctggtc ccaaccatta cagggtgaag 420 atatnaacag ttaaggaaga tacagtttng atgaggcctc anganggagc agntnacacc 480 atcatannca tatgcaggga a 501 182 830 DNA Homo Sapien misc_feature (1)...(830) n = A,T,C or G 182 ggcccttnga ngcatgctcg acggccgcca tgtgatggat atctgcagaa ttcgcccttt 60 cgagcggccg cccgggcagg tacacgagaa gctccgagga tggctgaagt ccaacgtctc 120 tgatgcggtg gctcagagca cccgtatcat ttatggaggc tctgtgactg gggcaacctg 180 caaggagctg gccagccagc ctgatgtgga tggcttcctt gtgggtggtg cttccctcaa 240 gcccgaattc gtggacatca tcaatgccaa acaatgagcc ccatccatct tccctaccct 300 tcctgccaag ccagggacta agcagcccag aagcccagta actgcccttt ccctgcatat 360 gcttctgatg gtgtcatctg ctccttcctg tggcctcatc caaactgtat cttcctttac 420 tgtttatatc ttcaccctgt aatggttggg accaggccaa tcccttctcc acttactata 480 atggttggaa ctaaacgtca ccaaggtggc ttctccttgg ctgagagatg gaaggcgtgg 540 tgggatttgc tcctgggttc cctaggccct agtgagggca gaagagaaac catcctctcc 600 cttcttacac cgtgaggcca agatcccctc agaangcang agtgcttgcc cttcccatgg 660 tgcccgtgcc tcttgtgctg ngtatgtgaa ccaccccatg tgagggaata aacctggcac 720 tangtctttg aaaaaaanaa aaacntnaaa aaaantccct tcggccgnga ccacgctaag 780 gnccaattcc ancacaatgg gcgnncgtna ctantggatc caaccttnct 830 183 484 DNA Homo Sapien misc_feature (1)...(484) n = A,T,C or G 183 ttgacatgat acccaacttg taccgagctc ggatccacta gtaacggccg ccagtgtgct 60 ggaattcgcc ctttcnagcg gccgcccggg caggtacccc agcccgcccc actgagtttg 120 ccttctatcc gggatatccg ggaacctacc agcctatggc cagttacctg gacgtgtctg 180 tggtgcagac tctgggtgct cctggagaac cgcgacatga ctccctgttg cctgtgggca 240 gttaccagtc ttgggctctc gctggtggct ggaacagcca gatgtgttgc cagggagaac 300 agaacccacc angtcccttt ttggaaggca gcatttgcag acttcaacgg gcaaaacctc 360 tgacgcctgc gcctttcgtc gcggncgcag aaaccatttc gnactttaan attgaatctt 420 ctctaaggtt ganaatttct ggatcccttg anaactttta canntgnnct ttantccntt 480 taaa 484 184 824 DNA Homo Sapien misc_feature (1)...(824) n = A,T,C or G 184 ggccttagag ctgctcgacg gccgccatgt gatggatatc tgcagaattc gcccttagcg 60 tggtcgcggc cgaggtacca gattggccac tctagggtag aacaccaggt agattcctaa 120 ggttcctgac tccaggccct ggctcccagt tggcatctct ggacctactt ggggtcacag 180 tgaactcact gccctgaagg gaagatgcct ggctggatat gccacctgct gattggagag 240 tccttggacc ttgagtgaac acaggtggta gccaggcagt gatcatcata ggccttgggt 300 gagccccagt gctgtgttgg cttcaggtct gacacagagc tgtcccagtg gtagtcgcca 360 caggggtgct tgtgtcatca tcccttctcc agctccaggc agctcagcac agagacatag 420 tgtccatttg tttgagtgaa agtaaaagaa gagaacaaga gtctccacct agtaatccag 480 ggaattctcc cagatcttac ccaagacaac caaggcaaga gacacagcat tactgggctg 540 gaggtgcccc ctaatgcagg tatggctgca gtgaacaaag acttagatca caacacccaa 600 atcccttcta atagttggaa agccttncca agaaggatgc cggacaaaca agcccaaact 660 gtgaagacta caacaaatac ctaactcttt caatgcccag acactgaaga atatcccaaa 720 ctttaagacc atccatgaaa acatgacctt accaacaagc taaataagac accagtgacc 780 aatcccagag agatagagat atgtgtcctt tcnnacagag aatt 824 185 499 DNA Homo Sapien misc_feature (1)...(499) n = A,T,C or G 185 cacttgacnt gatacgccaa cttgtaccga ctcggatcca ctagtaacgg ccgccagtgt 60 gctggaattc gcccttagcg tggtcgcggc cgaggtactt tttctttttt nttntatttt 120 tttttttcgt ctccccaaag ctttatctgt cttgactttt taaaaaagtt tgggggcaga 180 ttctgaattg gctaaaagac atgcattttt aaaactagca actcttattt ctttccttta 240 aaaatacata gcattaaatc ccaaatccta tttaaagccc tgacagcttg agaaggtcac 300 tactgcattt ataggacctt ctggtggttc tgctgttacg tttgaagtct gacaatcctt 360 gagaatcttt gcatgcagag gaggtaagag gtattggatt ttcacagagg aagaacacag 420 ccgcanaatg aagggccagg cttactgagc tgccaatgga gggctcatgg gtgggacatg 480 gnaaagaagg cacctagcc 499 186 504 DNA Homo Sapien misc_feature (1)...(504) n = A,T,C or G 186 cacttgacnt gatacgccaa cttggtaccg agctcggatc cctagtaacg gccgccagtg 60 tgctggaatt cgcccttagc gtggtcgcgg ccgaggtacc tcaggaggtc tgcaagtgtg 120 tggttaggta aaaactganc tgtgcaaact cactgtatcc aagctcttct catgagagag 180 cggaacaacc tggcaagctt aaaggcaagt gttttcgttc ttttaattaa ataggctgtg 240 acaaaattaa caataaaact agcccagaac caaccagccc ggtaagtgtc gtgcaaatct 300 tgcagtaaca aaagaccatc tgagagacta cacgttggtc tccagtccta gcaagcgtcc 360 cattctctnc acattcttat caattgtagc ttgacatgtt atctccttgg cacattccat 420 aggaaaccag cctctttctn catctcgtag tcgntccccc ttataccagc catcgctgac 480 acgtttgata gatgaagacg acgt 504 187 822 DNA Homo Sapien misc_feature (1)...(822) n = A,T,C or G 187 gggcctctna gctgctcgnc ggccgccatg tgatggatat ctgcagaatt cgccctttcg 60 agcggccgcc cgggcaggta cgcggggact gggtttttct ccttttgtag ccttttcctt 120 tagtctcctc ttcccggtgg ttggtaaaaa gaggtgaatt gacagcctat gttgaagaca 180 ctgtgctttt ctcaagaagg acatccaaac agcaagtcta cttctttctc tttaacgatg 240 tgctcattat caccaagaag aagagtgaag aaagttacaa cgtcaatgat tattccttaa 300 gagatcagct attggtggaa tcttgtgaca atgaagagct taattcttct ccagggaaga 360 acagctccac aatgctctat tcaagacaga gctctgccag tcacctcttt actctgacag 420 tccttagtaa ccacgcgaat gagaaagtgg agatgctact aggagctgag acgcagagcg 480 agcgagcccg ctggataact gccctgggac acagcagcgg gaagccgcct gcagaccgaa 540 cctcactgac ccaggtggaa atcgttaggt catttactgc taagcagcca gatgaactct 600 ccctgcaggt ggctgacgtc gtcctcatct atcaacgtgt cagcgatggc tggtatgagg 660 gggaacgact acgagatgga gaaagaagct ggtttcctat ggaatgtgcc aaggagataa 720 catgtcaagc tacaattgat aagaatgtgg agagaatggg accttgctag gactggagac 780 caacgtgtag tctctcaaan gncttttggt actgcaagat tg 822 188 504 DNA Homo Sapien misc_feature (1)...(504) n = A,T,C or G 188 tatgancatg atacgccaac ttggtaccga gctcggatcc actagtaacg gcccgccagt 60 gtgctggaat tcgcccttag cgtggtcgcg gccgaggtac caaaaaagta aacattgata 120 atatggcctg acaacaatca gatatgctaa gctctagaag caaaagcaag gtaggattgc 180 ctccaaatgt tgacaggtat tagccatacc acagtaacta gatctaatgt gagggctaaa 240 tgcctggaga ggcagaaccc taaaggatgc ttagttatag ctccatgctg ccgccgagtg 300 gcttgatgct ccattacacc ctccttggat ccaaccttcc attaaggctg aaggctctag 360 agggcagagt attcaagatg ttagatctgg tccaagccca aattctagag ttaaaagcag 420 aggggttctt agtggctgaa aaaaaacaaa acctgatgac atttgggact ccagttttga 480 ggaaaggctc tgatgatgag gctt 504 189 842 DNA Homo Sapien misc_feature (1)...(842) n = A,T,C or G 189 nnnnnnnntt tttgaaccgg ccctntnang catgctcgac ggccgccatg tgatggatat 60 ctgcagaatt cgccctttcg agcggccgcc cgggcaggta cccttctcgc ttttgccatt 120 agccaaggat agaagctgca gtggtattaa ttttgatata atctttcaaa ccagcttcat 180 gtggcttccc ttttctttgt tcaagatgag ggccaggagg ggaaacatca cacctgccct 240 aaaccctgtt cctggaggtc agcatttgat ctgttgcaag cccctctttc tgtcccctct 300 tcctaccctg cctcccatga ctttgctcct cacacttttg gaaccatgcc ttccgggggg 360 gcccatctct tctggccgtc cttgtctctg ggccacttgg agtgtgtgat aaatcagtca 420 agctgttgaa gtctcaggag tctctggtag cctgcagaag taagcctcat catcagagcc 480 tttcctcaaa actggagtcc caaatgtcat caggttttgt tttttttcag ccactaagaa 540 cccctctgct tttaactcta gaatttgggc ttggaccaga tctaacatct tgaatactct 600 gccctctaga gccttcagcc ttaatggaag gttggatcca aggagggtgt aatggagcat 660 caagccactc ggcggcagca tggagctata actaagcatc ctttagggtt ctgcctctcc 720 aggcatttag cccctacatt agatctagtt actgtggtat ggctaatacc tgtcaacatt 780 tggaggcaat cctaccttgc ttttgcttct agagcttagc atatctgatg gttgcaggcc 840 cg 842 190 503 DNA Homo Sapien misc_feature (1)...(503) n = A,T,C or G 190 actatgacct gattacgcca agcttggtac cgagctcgga tccctagtaa cggccgccag 60 tgtgctggaa ttcgcccttt cgagcggccg cccgggcagg taccatgctg acttcttggt 120 atcttttaag gcctaatttt cccttccttg agattactgt agtgtgttcc agctaatttc 180 tatttggaaa cgagttggaa cagctgaaaa ctaggtatta ttgaaggcaa agcagcctca 240 cgtcagtttt ttatcagctc atttgggaag tttttttttt ttttttttaa ttaattagaa 300 agtaggctgg acacggtggc tcatgcctat aatcccagca cttggggagg ccgaggatct 360 cctctctggt ggatcacttg agggcaggag ttaagagacc atcctggcca acatgatgaa 420 accctgtctc tactaaaaat acaaaaagta nctgggcgtg gtggcatact cttacaatcc 480 cagctacttg ggaggctgag gca 503 191 829 DNA Homo Sapien misc_feature (1)...(829) n = A,T,C or G 191 gggcctctga gcatgctcga cggccgccat gtgatggata tctgcagaat tcgcccttag 60 cgtggtcgcg gccgaggtac tttttttttt tcttttttta catctgattt taatgcttcg 120 ttaacttcaa aaggaactgg tagagttcag aaggtgagct gttgtttttc taaacctctt 180 cccaggaagg ggacattgac acttgaattt ttgtcacctt tttcctcatt agaaggaaag 240 tagaaagcct tactgtagga tttttaaaaa aaaatccatc tcaccccata ttggtcttaa 300 ataagtatag actaattaac ctaagctacc tttaacaacg tagaatttag atgggttcat 360 atatgtgaga aaaacctgaa tataggacag gggtcctact tttttcccca cctctgtcgc 420 ccaggctaga gtatagtggt gtgatcttgg cccactgcaa cctctgcttc ctaggttcaa 480 gtgattctcc tgcctcagcc tcccaagtag ctgggattgt aagagtatgc caccacgccc 540 agctactttt tgtattttta gtagagacag ggtttcatca tgttggccag gatggtctct 600 taactcctgc cctcaagtga tccaccagag aggagatcct cggcctnccc aagtgctggg 660 attataggca tgagccaccg tgtccagcct actttctaat taattaaaaa aaaaaaaaaa 720 aaactttcca aatgagctga taaaaaactg acgtgaggct gctttgcctt caataatacc 780 tagttttcag ctgtccaact cgtttccaaa tagaaattaa gctgggang 829 192 503 DNA Homo Sapien misc_feature (1)...(503) n = A,T,C or G 192 ntatgaccat gattacgcca agcttggtac ccgagctcgg atccactagt aacggccgcc 60 agtgtgctgg aattcgccct ttcgagcggc cgcccgggca ggtactgcct ttgggcttct 120 tctctctcct gttttctcct ctcgaattct ttactgtttt aatacattgt tcttctggct 180 gaggctggtc aaagctacac tgatcttcaa ataaaggctc gtcaatgcta cactgttctt 240 caagcaacgg ctggtgaact tgttctgaca aaggatggtc gacttttctt gcttgcttcc 300 tatgtctttc ctcttcagct aaatagagat gtttcagatt atctgggtat cgatctgtga 360 attgagattc cagtgacgtt tgagccttct tttccttccg tagcaatttc ttgtaacttt 420 gctgtatttt cagttttctt cgaaaagcaa agccttgtcc ctcgcgaacg ctccccacga 480 agcttgcggg tggttaggcc gca 503 193 834 DNA Homo Sapien misc_feature (1)...(834) n = A,T,C or G 193 ancggctctc tagagctgct cgacggccgc catgtgatgg atatctgcag aattcgccct 60 tagcgtggtc gcggcncgag gtacaattca ttatgtgttt cattaattac ctttattaaa 120 aacaacacaa ttatattaca atagggacaa aaaatgttta agcaaatgaa aacgaaacca 180 tgacataccc aaactcagga ggaggcaaca aaggcagtgc taaagggaag cttacagctc 240 cagatgctta aattaaaaag aagaaagatc tcaaacccat gctaaaggga agcttacagc 300 tacagatcct taaattaaaa agaagaaaga tctcaaaccc atgctaaagg gaagcttaca 360 gctgcagatg cttaaattaa aaagaagaaa gatctgaaac ccttgctaaa gggaagctta 420 tagctgcagg tgcttaaatt aaaaagaaga aagatctcaa atcaataacc taacattaca 480 cctgaagggg gggaaaaaaa ctaatgacaa accaagcaaa aggaagaaaa taacagatta 540 gagcagagat aagcagaata agaccagaaa aaaggaaaaa aacactgagt ttgttttttt 600 aaagatcaat aaaaatttta aaactcacag ctatattaag aaaaaagaga aatctcaaat 660 actaaaatca taagtaaaag angtgacagt acaggaataa gaatgtgaga cagaagacat 720 ggcggcctac cacccgcaag ccttcgtggg gagcgttcgc ganggacaag gctttgcttt 780 tcgaagaaaa ctgaaaatnc cgcaaagttc cagaaattgt tcngaagaaa agaa 834 194 502 DNA Homo Sapien 194 cacttgacct gattcgccaa gcttggtacc gagctcggat ccctagtaac ggccgccagt 60 gtgctggaat tcgccctttc gagcggccgc ccgggcagga cgctgaggcc tgggagtctc 120 ttgactccac tacttaattc cgtttagtga gaaacctttc aattttcttt tattagaagg 180 gccagcttac tgttggtggc aaaattgcca acataagtta atagaaagtt ggccaatttc 240 accccatttt ctgtggtttg ggctccacat tgcaatgttc aatgccacgt gctgctgaca 300 ccgaccggag tacctcggcc gcgaccacgc taagggcgaa ttctgcagat atccatcaca 360 ctggcggccg ctcgagcatg catctagagg gcccaattcg ccctatagtg agtcgtatta 420 caattcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg ttacccaact 480 taatcgcctt gcagcacatc cc 502 195 848 DNA Homo Sapien misc_feature (1)...(848) n = A,T,C or G 195 gnnnnnnntt tnnaatgggc ctctnnagca tgctcgagcg gccgccatgt gatggatatc 60 tgcagaattc gcccttagcg tggtcgcggc cgaggtactc cggtcggtgt cagcagcacg 120 tggcattgaa cattgcaatg tggagcccaa accacagaaa atggggtgaa attggccaac 180 tttctattaa cttatgttgg caattttgcc accaacagta agctggccct tctaataaaa 240 gaaaattgaa aggtttctca ctaaacggaa ttaagtagtg gagtcaagag actcccaggc 300 ctcagcgtcc tgcccgggcg gccgctcgaa agggcgaatt ccagcacact ggcggccgtt 360 actagtggat ccgagctcgg taccaagctt ggcgtaatca tggtcatagc tgtttcctgt 420 gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca taaagtgtaa 480 agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct cactgcccgc 540 tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag 600 aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt 660 cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaataccgg tattcacaga 720 attcagggga taacgcagga aagaacatgt gagcaaaagg ncagccaaag gccaggaacc 780 cgtnaaaagg ccgcgttgct ggcgttnttc cataggctcc gcccccttga cgagcatnac 840 aaaaatct 848 196 511 DNA Homo Sapien misc_feature (1)...(511) n = A,T,C or G 196 canntatgac ctgattacgc caagcttggt accgagctcg gatccactag taacggccgc 60 cagtgtgctg gaattcgccc ttagcgtggt cgcggccgag gtactttttt tttttttttt 120 tttttttttt ttttagggtt ataaaagccc ttttataaag ccatttttaa acaaaacaaa 180 aaaaaagttt acaaaagaaa aaaagatnca gaaaaagaat aacttgcttc atatgtccca 240 aaaagagaaa aaaataaagg ggacaatgcc aacatgctca acaataaagg cttctttttc 300 ttattttttt aatacaaaat ncaagcaaag gatacacata cttaaaacag agctcaggag 360 canacacgca ntcctggaaa cccttcaata aaancaaagc aggagtttgn tttttctttg 420 tctatgcana tacatacaga gactgggata tgtaaaaatt aagtatnaca aaagaccatt 480 acacgattct accaatgcat gttgcatctn g 511 197 816 DNA Homo Sapien misc_feature (1)...(816) n = A,T,C or G 197 gggcctctag agcatgctcg acggccgcca tgtgatggat atctgcagaa ttcgcccttt 60 cgagcggccg cccgggcagg tactaaggaa gttaaagttt gaatgtaacc actttattta 120 aaaggttttt ttctttaatt taaatgaaat ggggttgaag tgaacatgat tttgttgacc 180 atgttcgtga attacagatg caacatgcat tggtagaatc gtgtgatggt cttttgtgat 240 acttaatttt tacatatccc agtctctgta tgtatctgca tagacaaaga aaaaacaaac 300 tcctgctttg cttttattga agggtttcca ggactgcgtg tctgctcctg agctctgttt 360 taagtatgtg tatcctttgc ttgtattttg tattaaaaaa ataagaaaaa gaagccttta 420 ttgttgagca tgttggcatt gtccccttta tttttttctc tttttgggac atatgaagca 480 agttattctt tttctgtatc tttttttctt ttgtaaactt tttttttgtt ttgtttaaaa 540 atggctttat aaaagggctt ttataaccct aaaaaaaaaa aannnnnnna aaaaaaaaaa 600 gtcctcggcc gcgaccacgc taagggcgaa ttccagcaca ctggcggncg ttactagtgg 660 atccgagctc ggaccaagct tggcgtaatc atggncatag ctgttcctgt gtgaaatgtt 720 atccgctcac aattcccaca catacaaccc ggagcataaa gtgtaaacct ggggtgccta 780 atgagtgagc tactcaataa ttgcgttgcg ctcang 816 198 498 DNA Homo Sapien misc_feature (1)...(498) n = A,T,C or G 198 tgattcgcca agcttggtac cgagctcgga tccactagta acggcccgcc agtgtgctgg 60 aattcgccct tcgagcggnc gnccgggcag gtacaattca gagcaggtgt ccatagaaac 120 aactaggntt gaaaaaactg taagacaatt cacagttgaa atcaaaccaa cactgtgaat 180 gtgttaaata cttgccatat aacaacactt taacattgat cttgctaaat aaggctatga 240 ttcataagat gcatggattt ccaaagctgn ttaacattct tataaattaa ttcacaggat 300 tcaaatagtt gctttttagc ttcaactggg tattagcaaa aatnatacaa aatgatcccc 360 gtgcaagcac aaatttacct tccttctaaa taaaacatga cagattatat tacaacttga 420 tagcctctct tttaaaaagt ctgtgacatt attaaagagg tgacggaatg cttgntttgc 480 aaaccccaac acatcttt 498 199 837 DNA Homo Sapien misc_feature (1)...(837) n = A,T,C or G 199 nnnnnnntnn cantgggcct ctagagctgc tcgacggccg ccatgtgatg gatatctgca 60 gaattcgccc ttagcctggt cgcggccgag gtaccttgag atctgagcaa ctgtgttaat 120 gaagtaatag caatggtcca cagtgaaaga tgtgttgggg tttgcaaaac aagcattccg 180 tcacctcttt aataatgtca cagacttttt aaaagagagg ctatcaagtt gtaatataat 240 ctgtcatgtt ttatttagga aggaaggtaa atttgtgctt gcacggggat cattttgtat 300 tatttttgct aatacccagt tgaagctaaa aagcaactat ttgaatcctg tgaattaatt 360 tataagaatg ttaaacagct ttggaaatac atgcatctta tgaatcatag ccttatttag 420 caagatcaat gttaaagtgt tgttatatgg caagtattta acacattcac agtgtttgtt 480 tgatttcaac tgtgaattgt cttacagttt tttcaaacct agttgtttct atggacacct 540 gctctgaatt gtacctgccc gggcggccgc tcgaagggcg aattccagca cactggcggc 600 cgttactagt ggatccgagc tcggtaccaa gcttggcgta atcatggtca tagctgnttc 660 ctgtgtgaaa ttggtatccc gctcacaatt ccacacaaca tacgagccgg aagcataaag 720 tgtaaagcct ggggtgccta atgagtgagc taactccatt aattgcgttg cgctcactgg 780 cccgctttnc agtcnggaaa cctgtctgcc anctgcatta atgaatcggc caccccg 837 200 506 DNA Homo Sapien misc_feature (1)...(506) n = A,T,C or G 200 nnnnttgacc tgattacgcc aagcttggta ccgagctcgg atccactagt aacggccgcc 60 agtgtgctgg aattcgccct tagcgtggtc gcggccgagg tactgcatcc ataatttatc 120 gccatgtgca acagctttgc gttttctaag gcacaatttt taatgaaatg atgtgtagat 180 ttcaatctaa taacagctca tccaaatgac aaatatggtc gaaatccctc cagtggctga 240 ggaaatttct gcacctatat ggaacccaca tgcaaagaac ccatctagca tgtaataaat 300 aatcgctagc catactcaat aagacacgga aaaattattg cttacataac agaaaaacat 360 ctacttgacc cccttttatg actacatcaa tctattagga gtgtatccat agtctacatt 420 cacaaaatgt catcttgact tatttgccat tgatttaagg cagaataaat agtccccctt 480 tccccagtct taacaacaaa aaacaa 506 201 864 DNA Homo Sapien misc_feature (1)...(864) n = A,T,C or G 201 ccnntanagc atgctcgacg gccgcccggg caggtacctt ggaagttatg tcattaatat 60 aggctggttc atcaaataaa gcaaaacctt gcaatatcag ctagatttac actccgggac 120 gttgcccaaa ggtaggaaga aagcaggggg aaatatttca gtcatcattt ccaaagtcat 180 tatcaaaatc tgtgaggaag tttaatcttc caaagagtca atgtcagaca tcaggcctct 240 gttgcctgct tctctcgagg cactagatta ggagtcttca ataagagact taacatgagg 300 tatatggaag atgaggcacc gagataagtt catcattagg tgtgagcact gctcaccctt 360 gctggcaagt tctccttaag ggcctgaagc acaggtgtcc aaagaaaagc gttaagtcca 420 tcttaataga atctatgtgg tatatgatgt ggtcagcccc tggtctgtga tcagcaagaa 480 cctacagcac agattatgcc ctgcccactt caatgaatac ctactctcct ncattctcca 540 tcactttttt gctatcaaga ctccggacct tgcccatgga gaagtttaga gaggaactct 600 tgtggagagc tggttaattt tctgccctgt gcgacaagtt tcaacttggc caagaaangg 660 agtcaagtta ttaaaaagca tcacaatgta gaatcttcca ggctgggttt tttggntttt 720 tnggtggttn aanactgggg gnaaaagggg ggacctattt aaattccngg cctttaaaat 780 caaatgggcc aaaattaagt tcaaggaatg gaccattttt nggggnaaat ggttngaacc 840 ttntngggan ttcccncctt ccct 864 202 505 DNA Homo Sapien misc_feature (1)...(505) n = A,T,C or G 202 gnntnanacn nttnactaat antganttag tnccgactcg atccctctna ctncantnan 60 ancgntngaa ttgcccttnn tagcggccnt ccngncaggt acaaccagtt tggaaaacag 120 tntcacagtt tttttaaaaa ttacatatac aaccancaac tgacccagcc atttcactcc 180 taggtattta cccaagatna actgaagtgt agatacaagc anagacttgn gcacaagtgt 140 tcatggtaag ctttactngc antagctcca aactanggac aactcaaata gccaacangg 100 aaatggacaa attatgttac tttcatacag tggaatattc tcttgtgata aaaataantg 160 aacanttgat acatggatga atctcaaaat aattatgctg agtaaaagaa gccagacaaa 120 atgtacagtg catacagcta ttcatgtggg tgccagctcc atcccccagt gacctcttca 180 tacggncaga gggtggcatg gcanc 105 203 819 DNA Homo Sapien misc_feature (1)...(819) n = A,T,C or G 203 ggcctcngca gcatgctcga ncggccgcca tgtgatggat atctgcagaa ttcgccctta 60 gcgtggtcgc ggccgaggta cgcgggagag caggaccgga gcgcgggcca agctggagat 120 ggatgatgct gaccctgagg aaagaaacta tgacaacatg ctgaaaatgc tgtcagatct 180 gaataaggac ttggaaaagc tattagaaga gatggagaaa atctcagtgc aggcgacctg 240 gatggcctat gacatggtgg tgatgcgcac caaccctacg ctggccgatt ccatgcgtcg 300 gctggaggat gccttcgtca actgcaagga ggagatggag aagaactggc aagagctgct 360 gcatgagacc aagcaaaggc tgtaggcccc actggcccac cacagctgcc atgccaccct 420 ctgcccgtat gaagaggtca ctgggggatg gagctggcac ccacatgaat agctgtatgc 480 actgtacatt ttgtctggct tcttttactc agcataatta ttttgagatt catccatgta 540 tcaattgttc acttattttt atcacaagag aatattccac tgtatgaaag taacataatt 600 tgtccatttc cctgttggct atttgagttg tccctagttt ggagctattg cgagtaaagc 660 taccatgaac atttgtgcac aagtctttgc ttgtatctac acttcagttt atcttgggta 720 aatacctang agtgaaatgg cttgggtcaa tntgttggtt ggatatgtaa ttttttaaaa 780 aaaactgnga tactgttttc caaactgggt tgtccctct 819 204 840 DNA Homo Sapien misc_feature (1)...(840) n = A,T,C or G 204 gnnnnntttn nnctnntgga acccgttttg nnaagctgct cgacggccgc catgtgatgg 60 atatctgcag aattcgccct tagcgtggtc gcggccgagg taccttnaga tctgagcaac 120 tgtgttaatg aagtaatagc aatggtccac agtgaaagat gtgttggggt ttgcaaaaca 180 agcattccgt cacctcttta ataatgtcac agactttttt aaaagagagg ctatcaagtt 240 gtaatataat ctgtcatgtt ttatttagga aggaaggtaa atttgtgctt gcacggggat 300 cattttgtat tatttttgct aatacccagt tgaagctaaa aagcaactat ttgaatcctg 360 tgaattaatt tataagaatg ttaaacagct ttggaaatac atgcatctta tgaatcatag 420 ccttatttag caagatcaat gttaaagtgt tgttatatgg caagtattta acacattcac 480 agtgtttgtt tgatttcaac tgtgaattgt cttacagttt tttcaaacct agttgtttct 540 atggacacct gctctgaatt gtacccctca gtcaccagca aaagcatttc cacccctttc 600 aacccccaat cagaccactg cattcagtgg tattggagga ctttcatcac agcttccagt 660 aggtgggtct tggcacaggc agnctgactg gtatangaac tggtgctctt ggactccctg 720 cagtgaataa cgaccctttt gtacctgccc gggcggccgc taagggcgaa ttccacacac 780 tggccggccg ttactagtng gatccnaact cggtccaaan cttggcgtat tcatggtcnt 840 205 497 DNA Homo Sapien misc_feature (1)...(497) n = A,T,C or G 205 nnnnttgacc tgattacgcc aagcttggta ccgagctcgg atccactagt aacggccgcc 60 agtgtgctgg aattcgccct tagcgtggtc gcggccgagg tacatttact ataaaagctg 120 ttgcatttta gacaacttgt tgtttttatt ttttactgtt tctcagaggc attttagaat 180 aaatacttta aatgaaagtt agtataaccg atatagaaca ctggcccacc cagagcagta 240 acatcttttg gacggactca catatgaggt ggatcatttc agtttgttaa atcttacact 300 gtgtatagat aactataata tgtattgcat taatcacact acatagaaag gaaatgtcat 360 ggaagttcgc tagtgaaaaa caaaaagtta cccattattt ttattaaaga gtagggacta 420 gcttttggag tatgagaaaa aaaatcagat atacttcctc aggaacaata aatcactcac 480 ttgcctcacc tgttttt 497 206 820 DNA Homo Sapien misc_feature (1)...(820) n = A,T,C or G 206 gggcctntag aagcatgctc gagcggccgc cagtgtgatg gatatctgca gaattcgccc 60 tttcgagcgg ccgcccgggc aggtacatgt attgaagcta gaatcgagtc aagaaaaata 120 aagccccatt ctccaactgc aaaatgtgct ttcccataat gaacactagt caccagcaca 180 gaataatctc caacattttc taaattctaa ttgccaactg tttctattta tatttgattt 240 atatttcatt tggagtctgt tacatggcag cttaggcaga ctagatcttg ttttttccaa 300 tgcagcataa tgagtatgat ctatttcttt tcaaataatc tttgagatcc caggaaaaaa 360 aatgctctgc tccattgagc tataatgtaa atgtgtttgt ttaaaaaaca ggtgaggcaa 420 gtgagtgatt tattgttcct gaggaagtat atctgatttt ttttctcata ctccaaaagc 480 tagtccctac tctttaataa aaataatggg taactttttg tttttcacta gcgaacttcc 540 atgacatttc ctttctatgt agtgtgatta atgcaataca tattatagtt atctatacac 600 agtgtaagat ttaacaaact gaaatgatcc acctcatatg tgagtccgtc caaaagatgt 660 tactgctctg ggtgggccag tgttctatat cgggtatact aactttcatt taaagtattt 720 attctaaaat gcctctgaga aacagtaaaa ataaaaacca caagttgcta aaatgcaaca 780 gcttttatag taaatgtcct tgggccgcga ccacgcttag 820 207 496 DNA Homo Sapien misc_feature (1)...(496) n = A,T,C or G 207 cnnttgacct gattacgcca agcttggtac cgagctcgga tccactagta acggccgcca 60 gtgtgctgga attcgccctt agcgtggtcg cggcccgagg tacaaaagac aaaatcagag 120 ttcaatttca gcagcaagac ttatcaagaa tttaatcact atttgacatc aatggttggt 180 tgcctgtgga cgtccaaacc ctttgggaaa ggaatatata ttgaccctga aatcctagaa 240 aaaactggag tggctgaata taaaaacagt ttaaatgtag tccatcatcc ttctttcttg 300 agttacgctg tttccttttt gctacaggaa agcccagaag aaaggacagt aaatgtgagc 360 tctattcngg gaaagaaatg gagctggtat ttggactatt tattttcaca ngggttacaa 420 ggcttgaaac tttttataag aagtagtggt catcattctt ncattcccag agcagaaggc 480 ataaactgca caatca 496 208 810 DNA Homo Sapien misc_feature (1)...(810) n = A,T,C or G 208 gcatgctcga cggcccgcca gtgtgatgga tatctgcaga aattcgccct ttcgagcggc 60 cgcccgggca ggtactcctt gaggatggca gtctgtcagt gaaatgaaaa tgggaactca 120 agatgagcca ctttgctcta gcaatgagga gtgagtttag tccagtgtgt tcagtttatg 180 tcaacattca tttaatattg attgttgcag tttatgccct ctgctctggg aatggaagaa 240 tgatgaacac tacttcttat aaaaagtttc aagccttgta acccctgtga aaataaatag 300 tccaaatacc agctccattt ctttccccga atagagctca catttactgt cctttcttct 360 gggctttcct gtagcaaaaa ggaaacagcg taactcaaga aagaaggatg atggactaca 420 tttaaactgt ttttatattc agccactcca gttttttcta ggatttcagg gtcaatatat 480 attcctttcc caaagggttt ggacgtccac aggcaaccaa ccattgatgt caaatagtga 540 ttaaattctt gataagtctt gctgctgaaa ttgaactctg attttgtctt ttgtacctcg 600 gccgcgacca cgctaagggc gaattccagc acactggcgg ccggtactag tggatccgag 660 ctcggtccaa gcttggcgta atcatgggca tagctgtttc ctggtgtgaa attgntatcc 720 gctcacaatt ccacacaaca tacgaaccgg aagcattaag tgtaaagcct ggggtgccta 780 atgagtgagc taacttacat taattgcgnt 810 209 495 DNA Homo Sapien misc_feature (1)...(495) n = A,T,C or G 209 cnnttgacct gattacgcca agcttggtac cgagctcgga tccctagtaa cggccgccag 60 tgtgctggaa ttcgccctta gcgtggtcgc ggccgaggta caactctcca gggcacaata 120 cgtttacagc tgcctttcct tcacatactt ttctaattca gaactactca caattctaag 180 caaattccca ttcacgaagt ctgtccataa tgcgaccttc tcttttttta acatatacat 240 cttaaaaaac aaatatataa aaaattctta ttttgctgga atgctttcaa tttttcacat 300 tttacatgat catcacattt atttcttata ttgaaaggca tggtttctgt tgacatgtcg 360 tgcaaagcca aaaaaaaaaa anaaaaaaaa aagggctgga ttgcttttca attggtctaa 420 cacttttcct tgtctaggct ttggatttta aagttcatga cagccccacc accagtagaa 480 accccaaggc ttgca 495 210 820 DNA Homo Sapien misc_feature (1)...(820) n = A,T,C or G 210 gggcctcaga gctgctcgan cggccgccat gtgatggata tctgcagaat tcgccctttc 60 gagcggccgc ccgggcaggt acccacgttt tgctccacac tccttgaccg caggggctcg 120 gacacaaacc cctgtcacca ggagagtcag tcagcactac ttgggagggc taaagggaaa 180 tttggaaata aaattccaaa gtttggagta aaaaaattca agtgttgatt ttatattctt 240 tccctttctg acacagccta aagcgtaggg ggaacatgtg tttatctgtg ggagataaac 300 aagatggagt cccaaagact ttaacaaaat atttttttaa aaatccacta gaatagaaaa 360 tacattattt agatatactt tatgctgaga gtgagtatat atgcttgtcc tatttaaact 420 tgtgagaaaa agtggtatcc cttgatacat ttagaaatat gggggctatc ttgtttcatt 480 gtgggggtgg ggcagaagga gaataaatgc aggatgaccc tgttgaagga atcttancat 540 ggccaacagg ggacgtttcc agtcgattac caggaaatgc aagccttggg gtttctactg 600 gtggtggggc tgtcatgaac tttaaaatcc aaagcctaga caaggaaaag tgttagacca 660 attgaaaagc aatccagccc tttttttttt nnnntttttt tttggctttg cacgacatgt 720 caacagaaac catgcctttc aatntaagga aataaatgtg atgatcatgt aaaatgtgaa 780 aaattgaaag cattncacca aataaggaat tttttatttn 820 211 499 DNA Homo Sapien misc_feature (1)...(499) n = A,T,C or G 211 canttgactg attacgccaa gcttggtacc gagctcggat ccactagtaa cggccgccag 60 tgtgctggaa ttcgccctta gcgtggtcgc ggcccgaggt acaactctcc agggcacaat 120 acgtttacag ctgcctttcc ttcacatact tttctaattc agaactactc acaattctaa 180 gcaaattccc attcacgaag tctgtccata atgcgacctt ctcttttttt aacatataca 240 tcttaaaaaa caaatatata aaaaattctt attttgctgg aatgctttca atttttcaca 300 ttttacatga tcatcacatt tatttcttat attgaaaggc atggtttctg ttgacatgtc 360 gtgcaaagcc aaaaaaaaaa aaaaaaaaaa aagggctgga ttgcttttca atngggtcta 420 acacttttcc ttgtctaggc tttggatttt aaagttcatg acagccccac caccagtaga 480 aaccccaagg cttgcattt 499 212 821 DNA Homo Sapien misc_feature (1)...(821) n = A,T,C or G 212 gggcccntan agcatgctcg agcggccgcc atgtgatgga tatctgcaga attcgccctt 60 tcgagcggcc gcccgggcag gtacccacgt tttgctccac actccttgac cgcaggggct 120 cggacacaaa cccctgtcac caggagagtc agtcagcact acttgggagg gctaaaggga 180 aatttggaaa taaaattcca aagtttggag taaaaaaatt caagtgttga ttttatattc 240 tttccctttc tgacacagcc taaagcgtag ggggaacatg tgtttatctg tgggagataa 300 acaagatgga gtcccaaaga ctttaacaaa atattttttt aaaaatccac tagaatagaa 360 aatacattat ttagatatac tttatgctga gagtgagtat atatgcttgt cctatttaaa 420 cttgtgagaa aaagtggtat cccttgatac atttagaaat atgggggcta tcttgtttca 480 ttgtgggggt ggggcagaag gagaataaat gcaggatgac cctgttgaag gaatcttagc 540 atggccaaca ggggacgttt ccagtcgatt accaggaaat gcaagccttg gggtttctac 600 tggtggtggg gctgtcatga actttaaaat ccaaagccta gacaaggaaa agtgttagac 660 caattgaaaa gcaatccagc cctttttttt tttttttttt ttggctttgc acgacattgt 720 taacagaaac catgcctttc aatattagaa ataaatgtga tgatcatgtt aaatgtgaaa 780 aattggaagc cttcagcaaa ataagaattt ttatttnttt n 821 213 497 DNA Homo Sapien 213 acttgacctg attacgccaa gcttggtacc gagctcggat ccactagtaa cggccgccag 60 tgtgctggaa ttcgccctta gcgtggtcgc ggccgaggta caaaacaata gtctaaacta 120 acacgaactg ttacctggtc tattaaagga tacacggtat ccactaaaca gacagatcct 180 tatttccctg cttgatgttg caaagccctt ggcaaccagg ggcaaaggtc actggggttt 240 gactaactgg ggctgagtgg cagctatgac tgtccttcag atttttgagt tgtttttgaa 300 attaaaagct tctaaaagtt gcatcaacat cctcctaagc ccccatagga ttgtaacacc 360 accacaaaag gccaccaaca ctttttaaac aaagtgaaaa ctgtctgaca ccaatcatct 420 tgaaaactcc atggcaagtg cattagctat gatttcatca cttacaggta gagaagctta 480 ctgtctactg gtgtggg 497 214 817 DNA Homo Sapien misc_feature (1)...(817) n = A,T,C or G 214 ggccttanag ctgctcgncg gccgccatgt gatggatatc tgcagaattc gccctttcga 60 gcggccgccc gggcaggtac tctcagtcat atgcagaaat actttttttt taattaatag 120 ttacaggctt gttggtccag tgggatttgg gtagggggag aaagatacct tctaaaatgg 180 atcaatagaa ccaaaataat acagcatgtt ctataaccac aaggaaatca aatgatcctg 240 tcatgattcc agttagtcat aaccatgtta gcagtgctaa atgcatttta gaaatggtga 300 cttctgtggt tttcctagca tttgtctcta acaaatggtg aaataattac tcatggccct 360 ctctgccatt gtctttcatt ttttcacagt gaaattagac ccctttactt caccattctg 420 ccactgcaaa ttaagtataa agaaaatagc aagagtgtcc acaccagtag acagtaagct 480 tctctacctg taagtgatga aatcatagct aatgcacttg ccatggagtt ttcaagatga 540 ttggtgtcag acagttttca ctttgtttaa aaagtgttgg tggccttttg tggtggtgtt 600 acaatcctat gggggcttan gaggatgttg atgcaacttt tagaagcttt taatttcaaa 660 aacaactcaa aaatctgaag gacagtcata gctgccactc agccccagtt agtcaaaccc 720 cagtgacctt tgcccctggt tgccaagggc tttgcaacat caagcangga aataaggatc 780 tgnctgttag tgggataccg ggtatccttt aatagac 817 215 495 DNA Homo Sapien misc_feature (1)...(495) n = A,T,C or G 215 acttgacctg attacgccaa gcttggtacc gagctcggat ccactagtaa cggccgccag 60 tgtgctggaa ttcgccctta gcgtggtccg gccgaggtac catgctgact tcttggtatc 120 ttttaaggcc taattttccc ttccttgaga ttactgtagt gtgttccagc taatttctat 180 ttggaaacga gttggaacag ctgaaaacta ggtattattg aaggcaaagc agcctcacgt 240 cagtttttta tcagctcatt tgggaagttt tttttttttt ttttttaatt aattagaaag 300 taggctgggc acggtggctc atgcctataa tcccagcact tggggaggcc gaggatctcc 360 tctctggtgg atcacttgag ggcaggagtt aagagaccat cctggccaac atgatgaaac 420 cctgtctcta ctaaaaatac aaaaagtagc tgggcgtggt ggcatactct tacaatccca 480 gctacttggg aggcn 495 216 823 DNA Homo Sapien misc_feature (1)...(823) n = A,T,C or G 216 gggcctcaga gcatgctcgn cggccgccag tgtgatggat atctgcagaa ttcgcccttt 60 cgagcggccg cccgggcagg tacttttttt tcttttttta catctgattt taatgcttcg 120 ttaacttcaa aaggaactgg tagagttcag aaggtgagct gttgtttttc taaacctctt 180 cccaggaagg ggacattgac acttgaattt ttgtcacctt tttcctcatt agaaggaaag 240 tagaaagcct tactgtagga tttttaaaaa aaaatccatc tcaccccata ttggtcttaa 300 ataagtatag actaattaac ctaagctacc tttaacaacg tagaatttag atgggttcat 360 atatgtgaga aaaacctgaa tataggacag gggtcctact tttttcccca cctctgtcgc 420 ccaggctaga gtatagtggt gtgatcttgg cccactgcaa cctctgcttc ctaggttcaa 480 gtgattctcc tgcctcagcc tcccaagtag ctgggattgt aagagtatgc caccacgccc 540 agctactttt tgtattttta gtagagacag ggtttcatca tgttggccag gatggtctct 600 taactcctgc cctcaagtga tccaccagag aggagatcct cggcctnccc aagtgctggg 660 attataggca tgagccaccc gtgcccagcc tactttctaa ttaattaaaa aaaaaaaaaa 720 aaaaacttnc caaatgagct gatnaaaaac tgacgtgang ctgctttgcc ttcaataata 780 cctagttttc actggtccaa ctcgtttcca aatagaaatt acg 823 217 827 DNA Homo Sapien misc_feature (1)...(827) n = A,T,C or G 217 nnnnnnnggc ctntnnagca tgctcgacgg ccgccatgtg atggatatct gcagaattcg 60 ccctttcgag cggccgcccg ggcaggtact gtatcattgg cagatgtgac gtcaccgaca 120 accagagtga agtggcggac aaaactgagg attacctgtg gctgaagttg aaccaagtgt 180 gttttgacga cgatggcacc agctccccac aagacaggct cactctctca cagttccaga 240 agcagttgtt ggaagactat ggcgagtccc actttacggt gaaccagcaa cccttcctct 300 acttccaagt cctgttcctg acagcgcagt ttgaagcagc agttgccttt cttttccgca 360 tggagcggct gcgctgccat gctgtccatg tagcactggt gctgtttgag ctgaagctgc 420 ttttaaagtc ctctggacag agtgctcagc tcctcagcca cgagcctggt gaccctcctt 480 gcttgcggcg gctgaacttc gtgcggctcc tcatgctgta cctcggccgc gaccacgcta 540 agggcgaatt ccagcacact ggcggccgtt actagtggat ccgagctcgg taccaagctt 600 ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca 660 caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact 720 cacattaatt gcgttgcgct cactgcccgc ttttcaatcg ggaaacctgt cgtgccagct 780 gcattaatga atcggncaac gccccgggan aagcggtttg cgtattt 827 218 498 DNA Homo Sapien 218 cacttgacct gattacgcca agcttggtac cgagctcgga tccactagta acggccgcca 60 gtgtgctgga attcgccctt tcgagcggcc gcccgggcag gtactttttt tttttttttt 120 taattcccac aacaacccat ttcaaaatga gaaaactagg ttgagtgact tgtccacagt 180 tccaaagcta ataaaaatga tgaggcatat ttctcttctg ggcccactgt attcagttct 240 ttgttcttta cactgagtgc cgaaaaaaaa aaatcagact attttgattc tagaaagtga 300 gataattgaa aatgttaaca tatttctcca aaactgatca gactgtggag tctgtcactt 360 ttttggtata ataaaggagt ttgaagaaac aaatgacatc attcctgatg atggtagccc 420 actccaacaa aggcgtatat atgtaggcaa gtttgaagat atctataaga gcattaaaag 480 gcaagtgcac cattgtgg 498 219 818 DNA Homo Sapien misc_feature (1)...(818) n = A,T,C or G 219 ggcctntnga gctgctcgac ggccgccatg tgatggatat ctgcagaatt cgcccttagc 60 gtggcgcggc cgaggtacct agaaaacaga aacttgagta gacatggtaa tgaccagaaa 120 aggctatctt tatacatttc ttttgctacg cttcaaattc atgtcaccta aaagttgtga 180 agtgcacaaa acaaatctac ttaactgaaa attattttca atgaatggga tgtttagaac 240 tctgtgaggg tttttaaggt cttttcgaat agcaaattct aatgaggctt ttttaagttg 300 gcaatttaaa ctcatacaag aaataaaaac tcaccagtgt ggctgggcag aatatatata 360 ttttctcaaa tattgtttgt ttgttttttc cctgcactgt atccatggtc ccatgatgaa 420 actgttatat tgctgatata tttattggaa tatgtgggcc aacttccttt ccactcaaca 480 tatggattgg tagtttaaaa taattccttt ctattaagca aatgtgtggc taaggcacat 540 ttaaatagcc cattaaacca atgagatgac aatgtgttac cctcagagaa agcttaattt 600 ttggagtaat caattacaca tatcacagaa tgtctcatga gaacattttt ggctaggtct 660 accaatttat catgcaaata attatagatt ttcatttgag gcaaagatgc tgattcatca 720 ttagtaacat ggtcacaaat aatcatttat tttattttgg taacatctgt ctttcctgtg 780 gggaaactta ctatatgctc tacgttaatt aaattaaa 818 220 497 DNA Homo Sapien 220 cacttgacct gattacgcca agcttggtac cgagctcgga tccactagta acggccgcca 60 gtgtgctgga attcgccctt tcgagcggcc gcccgggcag gtacagccat gaaattgttg 120 ctactcatag aaagtcttag tatagtttgg tttaaacatt ttaaaattgc aaataaatat 180 agatagataa tatcatgatg agaaggtcac gggaagcctg gagatttcag ggtgctcttt 240 cataattgga gcgagaatca tgtaacagtt aagaaactaa actcttgagc cttcatagtc 300 tttgctttct ccccatttat ttatctgata ttatataccc tctttaatta tagactggac 360 tgaaatattt tatttttgtt ttattataaa aaatcctact cgtctttaac atgttctctt 420 aaagagtgtt tcatatataa atactttccc cccaaaatat aaagaggcta accactatag 480 tattgaaaga ttgaaag 497 221 831 DNA Homo Sapien misc_feature (1)...(831) n = A,T,C or G 221 cnnnannggg cctntanagc atgctcgacg gccgccatgt gatggatatc tgcagaattc 60 gcccttagcg tggtcgcggc cgaggtacaa tgaaagtatg agctacctct ctgaagtctg 120 gaaaccttga gagtattaag gttacatgca taaaatcttt aaaatggaag tgtcattaca 180 tggtaaacca attcaaatta aaaataatct catgctgtga aagcaaaata tataactggt 240 ttacccattc ataggtaatt gcacgtcttt gttacatctc aatagtttct ttgtatttgt 300 tgcaatcacc ctccttcttc tcaacactct tttctacctc catgtaactg ctgttgtgaa 360 ttctttataa tattctcatc aatgtttaaa gatgaagttt aaagtgctta caaaggaagc 420 attttaactc ctcttagaac tgagccttta aatttggttt tagacaccct aggtctttct 480 ttcaatcttt caatactata gtggttagcc tctttatatt ttggggggaa agtatttata 540 tatgaaacac tctttaagag aacatgttaa agacgagtag gattttttat aataaaacaa 600 aaataaaata tttcagtcca gtctataatt aaagagggta tataatatca gataaataaa 660 tggggagaaa gcaaagacta tgaaggctca agagtttagt ttcttaactg gtacatgatt 720 ctcgctncaa ttatgaaaga gcaccctgaa atctncangc ttnccgtgac cttctcatca 780 tgatattatc tatctatatt tattgcaatt ttaaaatggt taaaccaaac n 831 222 497 DNA Homo Sapien 222 cacttgacct gattacgcca agcttggtac cgagctcgga tccactagta acggccgcca 60 gtgtgctgga attcgccctt agcgtggtcg cggccgaggt actctttctc tcccctcctc 120 tgaatttaat tctttcaact tgcaatttgc aaggattaca catttcactg tgatgtatat 180 tgtgttgcaa aaaaaaagtg tctttgttta aaattacttg gtttgtgaat ccatcttgct 240 ttttccccat tggaactagt cattaaccca tctctgaact ggtagaaaaa catctgaaga 300 gctagtctat cggcatctga caggtgaatt ggatggttct cagaaccatt tcacccagac 360 agcctgtttc catcctgttt aataaattag tttgggttct ctacatgcat aacaaaccct 420 gctccaatct gtcacataaa agtctgtgac ttgaagttta gtcagcaccc ccaccaaact 480 ttatttttct atgtgtt 497 223 822 DNA Homo Sapien misc_feature (1)...(822) n = A,T,C or G 223 gggcctnaga gctgctcgnc ggccgccatg tgatggatat ctgcagaatt cgcccttcga 60 gcggccgccc gggcaggtac tttattttca aaaaactcat atgtcgcaaa aaacacatag 120 aaaaataaag tttggtgggg gtgctgacta aacttcaagt cacagacttt tatgtgacag 180 attggagcag ggtttgttat gcatgtagag aacccaaact aatttattaa acaggatgga 240 aacaggctgt ctgggtgaaa tggttctgag aaccatccaa ttcacctgtc agatgccgat 300 agactagctc ttcagatgtt tttctaccag ttcagagatg ggttaatgac tagttccaat 360 ggggaaaaag caagatggat tcacaaacca agtaatttta aacaaagaca cttttttttt 420 gcaacacaat atacatcaca gtgaaatgtg taatccttgc aaattgcaag ttgaaagaat 480 taaattcaga ggaggggaga gaaagagtac ctcggccgcg accacgctaa gggcgaattc 540 cagcacactg gcggccgtta ctagtggatc cgagctcggt accaagcttg gcgtaatcat 600 ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac aacatacgag 660 ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc acattaattg 720 cgttgcgctc actggccgct tttcagtcng gaaacctgtc gtgccagctg cattaatgaa 780 tcggccaacg cgccgggaga ngcngnttgc gtattgggcc cn 822 224 494 DNA Homo Sapien misc_feature (1)...(494) n = A,T,C or G 224 cncttgacnt gattacgcca agcttggtac cgagctcgga tccctagtaa cggccgccag 60 tgtgctggaa ttcgccctta gcgtggtcgc ggccgaggta cttttttttt tttttttaac 120 caactcaata tgtgtttgat gatagtgaat tgataaaacc cgaagctttt ccctgtaaat 180 cttacatctt tgcctttaaa gaatgggtta caaccatcac tagatcacag tagtgcctaa 240 tgaaggttga gaaccgtagg agaggctctc atgctgtaaa taatgttgca ggctaataac 300 ctttcatcac ttcctttgtg cgcttcctgc cttaagtgac aagtagcaac atggcttggg 360 tcccctgtgc agcatcagct tatgctgcca caagtcagtt tgcaccctag gtgcccagga 420 gctagtatcc ttagatcttt ctatcgctaa cttaattctc ttcgttattt atctgaccct 480 ctaactccat gtct 494 225 822 DNA Homo Sapien misc_feature (1)...(822) n = A,T,C or G 225 gggccttnga gctgctcgnc ggccgccagt gtgatggata tctgcagaat tcgcccttcg 60 agcggccgcc cgggcaggta ctttaatttt gcttgttcaa atgatctaca cttacatttt 120 gcaaatcttt ttttttaaat tttttaaatt ttatattttt tttccagcca actcaaggcc 180 aaaaaaaatt tcttaatata gttattatgc gaggggaggg gaagcaaagg agcacaggta 240 gtccacagaa taagacacaa gaaacctcaa gctgtgaggt caatttgtaa ttaaaagaat 300 actaagatta gatgaacaca acactcagaa atactctagg agagctgaaa aagaaggaac 360 agatgttaac aaaacaaatt aaggctgctg gggaacctga gtccatgtta agcttgggtt 420 gactgtaaag aatttttttt tttaatgcaa gttagacatg gagttagagg gtcagataaa 480 taacgaagag aattaagtta gcgatagaaa gatctaagga tactagctcc tgggcaccta 540 gggtgcaaac tgacttgtgg cagcataagc tgatgctgca caggggaccc aagccatgtt 600 gctacttgtc acttaaggca ggaagcgcac aaaggaagtg atgaaaggtt attagcctgc 660 acattattta cagcatgaga gcctctccta cggttctcaa ccttcattag gcctactgtg 720 atctantgat ggntgtaccc attctttaaa ggcaaagatg taaggattta cagggaaaag 780 cttcgggttt tatcaattca ctatcatcaa acacatattg ng 822 226 498 DNA Homo Sapien misc_feature (1)...(498) n = A,T,C or G 226 anntaaacta tgacctgatt acgccaactt ggtaccgagc tcggatccac tagtaacggc 60 cgccagtgtg ctggaattcg ccctttcgag cggccgcccg ggcaggtacc ctctcatata 120 tgcaaacaaa tgcagactag gcctcaggca gagactaaag gacatctctt ggggtgtcct 180 gaagtgattt ggacccctga gggcagacac ctaagtagga atcccagtgg gaagcaaagc 240 cataaggaag cccaggattc cttgtgatca ggaagtgggc caggaaggtc tgttccagct 300 cacatctnat ctgcatgcag cacggaccgg atgcgcccac tgggtcttgg cttccctccc 360 atcttctcaa gcagtgtcct tgttgagcca tttgcatcct tggctccagg tggctccctc 420 agtctggact ctaccacttg ggtctccaga ttttctgtta cgtccttgtg ggtcaggata 480 tttctggaag tcactccg 498 227 815 DNA Homo Sapien misc_feature (1)...(815) n = A,T,C or G 227 gggcctctna agctgctcga cggccgccat gtgatggata tctgcagaat tcgcccttag 60 cgtggtcgcg gccgaggtac attgatgggc tggagagcag ggtggcagcc tgttctgcac 120 agaaccaaga attacagaaa aaagtccagg agctggagag gcacaacatc tccttggtag 180 ctcagctccg ccagctgcag acgctaattg ctcaaacttc caacaaagct gcccagacca 240 gcacttgtgt tttgattctt cttttttccc tggctctcat catcctgccc agcttcagtc 300 cattccagag tcgaccagaa gctgggtctg aggattacca gcctcacgga gtgacttcca 360 gaaatatcct gacccacaag gacgtaacag aaaatctgga gacccaagtg gtagagtcca 420 gactgaggga gccacctgga gccaaggatg caaatggctc aacaaggaca ctgcttgaga 480 agatgggagg gaagccaaga cccagtgggc gcatccggtc cgtgctgcat gcagatgaga 540 tgtgagctgg aacagacctt cctggcccac ttctgatcac aaggaatcct gggcttcctt 600 atggctttgc ttccactggg attcctactt aggtgtctgc cctcaggggt ccaaatcact 660 tcaggacacc ccaagagatg tcctttagtc tctgctgagg cctantctgc atttggttgc 720 atatatgaaa aggtacctgc ccgggccggc cgttcnaang gcgaatttca gcacactggc 780 ggncgntact agtggatccc aactcggtac caagc 815 228 512 DNA Homo Sapien misc_feature (1)...(512) n = A,T,C or G 228 annnnntttn acctannact atgacctgat tacgccaact tggtaccgag ctcggatcca 60 ctagtaacgg ccgccagtgt gctggaattc gccctttcga gcggccgccc gggcaggtac 120 taggtttgca aaaccaatag catgcacatg tgttgggctg aggttcatgt gtcagagact 180 cagttgtaga aggaactttg aatctggcag gcacttaact gtggctgctc agaactaatg 240 tatctggggc tgcttgagca ggggctgagg tcagaggcag ggagtgagct ctccatcatc 300 cttgactcag acccagctcc gcaggagctc catggtcatc cctggagctc atgtggagtg 360 caaggtccgg gagtgggggc gctgacagaa acaaatctgg ggggatcagc cagggtcagc 420 aggggacaga gatcatgtct tttagaagaa tgtgggcttc ctgacctata gaagggcagc 480 tgttcacccc ctgcagatga tagcagggat ng 512 229 815 DNA Homo Sapien misc_feature (1)...(815) n = A,T,C or G 229 gggcctnaga gcatgctcga cggccgccat gtgatggata tctgcagaat tcgcccttag 60 cgtggtcgcg gccgaggtac tttttttttt tttttttttt ttcagagata ggttcttact 120 atgctgccct ggctggagtg cagtggcttt cttaggggca atcacagctc actgcagcct 180 ggaactcctg ggctcagcct cctaagtagt tgagactacc aatgcacgcc accatacctg 240 gccttagata ccccctgtat cctggaactc actccttata agagacactg aatgtggaag 300 tcttcgcaga tattaagggc actgcccagt tcctgtcttt gaattattgg gccaacaaca 360 gaaaggcgct cctgaggccc cagatcatcc ctgctatcat ctgcaggggg tgaacagctg 420 cccttctata ggtcaggaag cccacattct tctaaaagac atgatctctg tcccctgctg 480 accctggctg atccccccag atttgtttct gtcagcgccc ccactcccgg accttgcact 540 ccacatgagc tccagggatg accatggagc tcctgcggag ctgggtctga gtcaaggatg 600 atggagagct cactccctgc ctntgacctc agcccctgct caagcagccc cagatacatt 660 agttctgagc agcccagtta agtgcctgcc agattcaaag ttccttctac aactgagtct 720 ctgacacatg aaccttaagc ccaacacatg tgcatgctat tgggttttgc aaacctagta 780 cctgnccggg cgggccgttc gaaanggcga attct 815 230 502 DNA Homo Sapien misc_feature (1)...(502) n = A,T,C or G 230 tnnanctana cttgacctga ttacgccaac ttggtaccga gctcggatcc actagtaacg 60 gccgccagtg tgctggaatt cgccctttcg agcggccgcc cgggcaggta cacagagatg 120 cggtccagct gcaggtcgct gtccccgtgg taggtgccgg tggggtcgat gccatgttca 180 tcactgatca cctcccagaa cttggcaccg atctggtagc cacactgacc agcctggatg 240 tgcacgattt ccctcatggt taaaatttaa tttttttgct cgcctcaagg tatgtatggg 300 gcaagaaaat aagtaatttt ttttctccgc aggtcgcagg ctggaaggtt ggaatgcgcc 360 ccagaggctg gagcagcgag gtgcaaacgc gacggcagga aggttctgag agccccgcgt 420 acctcggccg cgaccacgct aagggcgaat tctgcagata tccatcacac tgcggccgct 480 cgagcatgca tctagagggc cc 502 231 817 DNA Homo Sapien misc_feature (1)...(817) n = A,T,C or G 231 nngggcctct nnagctgctc gacggccgcc atgtgatgga tatctgcaga attcgccctt 60 agcgtggtcg cggccgaggt acgcggggct ctcagaacct tcctgccgtc gcgtttgcac 120 ctcgctgctc cagcctctgg ggcgcattcc aaccttccag cctgcgacct gcggagaaaa 180 aaaattactt attttcttgc cccatacata ccttgaggcg agcaaaaaaa ttaaatttta 240 accatgaggg aaatcgtgca catccaggct ggtcagtgtg gctaccagat cggtgccaag 300 ttctgggagg tgatcagtga tgaacatggc atcgacccca ccggcaccta ccacggggac 360 agcgacctgc agctggaccg catctctgtg tacctgcccg ggcggccgct cgaaagggcg 420 aattccagca cactggcggc cgttactagt ggatccgagc tcggtaccaa gcttggcgta 480 atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat 540 acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct aactcacatt 600 aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta 660 atgaatcggc caacgcgcgg ggagaggcng nttgcgtatt gggcgctctt ccgcttnctc 720 gctcacttga ctcgcttgcg ctcggtcgtt cngcttgcgg cnanccggat tcagcttact 780 taaaggcggt aataccggtt atccaccaga attangg 817 232 481 DNA Homo Sapien 232 actatgacct gattacgcca agcttggtac cgagctcgga tccactagta acggccgcca 60 gtgtgctgga attcgccctt tcgagcggcc gcccgggcag gtacaaattt gttgtgtttt 120 ttatgttcta ataatactga gacttctagg tcttaggtta atttttagga agatcttgca 180 tgccatcagg agtaaatttt attgtggttc ttaatctgaa gttttcaagc tctgaaattc 240 ataatccgca gtgtcagatt acgtagagga agatcttaca acattccatg tcaaatctgt 300 taccatttat tggcatttag ttttcattta agaattgaac ataattattt ttattgtagc 360 tatatagcat gtcagattaa atcatttaca acaaaagggg tgtgaaccta agactattta 420 aatgtcttat gagaaaattt cataaagcca ttctcttgtc attcaggtcc agaaacaaat 480 t 481 233 809 DNA Homo Sapien misc_feature (1)...(809) n = A,T,C or G 233 gggcctctnn agcatgctcg acggccgcca tgtgatggat atctgcagaa ttcgccctta 60 gcgtggtcgc ggccgaggta caaaagatac tgttcacccc attagagaac tgatttgaag 120 ttactcttcc ctgtgagggc tctgtcatct taactgtatt cacatacttt caactgttcc 180 ccttgctgct aacctcaggt tctttagttc atctatctgg cagagctgat ttggggaaaa 240 caagacaaac cttgtcaggt tttcttaata aataagcagt tgtcatgttt caagagtttt 300 agaaatgagc aataatcaag gaagaggaca acgattgcat acgtttataa tatttagaac 360 atcttttgcc acaataaaca ctggaaacca cccacttgtg gacaccaaac atttggattt 420 gtatattttg tggcattccc tcactctaat cctctcatcc ttaaaaattt tcagaaattt 480 ttgcagcaac aaacactgat tgcaacatat gatttagggt agatttatga accatttttt 540 cactgaaata catcaacagg agtgagtagt ctgagtgacc accccagcat ggagaaaact 600 gtagtttaca gattcttctg gagcattttt atttctagat tgcagtggaa gtctaacccc 660 ccttggagat gtctgcctta aagggtcttt ggccagggtc ctctgtagag ccatagtcca 720 gatctactct atttgngtgc tccttacaac atcagaacag caactctcaa tccggatcat 780 cccagaatgc cgctgagtca cagcgtggg 809 234 482 DNA Homo Sapien misc_feature (1)...(482) n = A,T,C or G 234 actatgacca tgattacgcc aagcttggta ccgagctcgg atccactagt aacggccgcc 60 agtgtgctgg aattcgccct tcgagcggcc gcccgggcag gtactgaaaa gaagatagtg 120 ccatttgaaa caacagatgc atcttttata cattttcaca agttngtttt tcatattttt 180 aaaggcccca tttatctgta acagtggtat ttttatttag agtatcggct acttaatata 240 tacatgcaac aatatatgct ttaatagtca tttaactttt angaatattt catnacatta 300 agtggttaag catagcgtta aaagagtgga atataaggaa tannaanntn tngaaaatac 360 gctgctannt tcattngcan actatagtag aatggagatg cccataaaag tgatcattgc 420 ccaactgaat tcctacccng aactaacatg tgattctcaa gtgggganaa atattattaa 480 aa 482 235 474 DNA Homo Sapien misc_feature (1)...(474) n = A,T,C or G 235 acttgacctg attacgccaa gcttggtacc gagctcggat ccactagtaa cggccgccag 60 tgtgctggaa ttcgccctta gcgtggtcgc ggccgaggta cattacttgg tgttaacatt 120 gttggcagtg gtagcccctt ttcagaaagc aacttgctgt aagtcagggt gtccgttcca 180 accttcagct agtgaaaagg tagtaacaaa tggtaaacaa gagaatgatt gtttaaacct 240 atctgtggac acttaatgca actgtttaaa aatgataatc acgagttatg tagcaacgtg 300 gaaatatatt tacagaacat taatggagaa gcagggacac gaagtatatt atactacagt 360 tataactcaa cagtcattat atgccggtca tttaccagtc atttaaccag ttcattataa 420 ctgtttaaaa atatatatgc ttatagtcaa aagctgttgt ggtgttgttg ttgn 474 236 819 DNA Homo Sapien misc_feature (1)...(819) n = A,T,C or G 236 gggccttnna gctgctcgnc ggccgccagt gtgatggata tctgcagaat tcgccctttc 60 gagcggccgc ccgggcaggt actttttttt tttttttttt tttttatttt taactttatt 120 tttattgntg acactattac agatagaatg accacaacca tattaacaaa ccaaaaacct 180 gtgcacagaa acaagatgaa gaaaatatat caagatgtta aacacactct ttggatggtg 240 aaaacatggg tgagtttctc ttctacattt ctgtaacttc aaagtttcta taatgaacac 300 atttcatata taatggaaat atatgtagta aaggtggact accaaaacac tagaatgatg 360 acctttcaag gaaaccgaaa caaaataacc ataatcccac aacaaccaca caactatttc 420 ttgnttttca tctttcttcc catctttgac atttatgcat acttatcact aacaccctaa 480 taatcacaga ctagtgcaca gatcaagatg ttaacagtta attgttgttg ggtgttggga 540 atatgtgtga attttcttta ctgaatttcc aaagttttgt atgagtatgt attatatttg 600 taatggaaaa tacatacata aaatttatta ccaaaacacc aaagattatt taagggaatt 660 tgagacaaaa tatttaacca aattcccaca atgacaacac tattttagtt attttccaca 720 tcttttcatt taagacttta tgcacacata tttaacactg gtatcacaag cgtgggcact 780 gaaacaagga tnganggaac nggatcagga tgttagccg 819 237 483 DNA Homo Sapien misc_feature (1)...(483) n = A,T,C or G 237 agcttgacct gattacgcca agcttggtac cgagctcgga tccactagta acggccgcca 60 gtgtgctgga attcgccctt agcgtggtcg cggccgaggt actaagctca gcatgtctca 120 tggtcaatta ctgcgtattt ccaaaaaatg tgttgtttgg tcttgagaaa attctttagc 180 cccttgacac cagaattatc tccactgtag aaaaaataga caattatagt ctaacaggta 240 aatcacaaaa attcttcagc cacacttcct gggttcaaat gtggtttttc tactcagtaa 300 tattgtaacc ctgggcaagt tatttaactt gtctaagtct cagtttctcc atctgtaaaa 360 tgaggataat cacaatatct actacataat gttcttctga agatgtaatg agataatcca 420 tgtnaaatat tcanacagca cataggaatg ggtcatttaa tgtttatcat tacttgccta 480 ttt 483 238 815 DNA Homo Sapien misc_feature (1)...(815) n = A,T,C or G 238 gggcccntnn agctgctcgn cggccgccag tgtgatggat atctgcagaa ttcgcccttt 60 cgagcggccg cccgggcagg taccattatt tttcattcaa taccatatgt ctgaaaaata 120 ggcaagtaat gataaacatt aaatgaccca ttcctatgtg ctgtctgaat attttacatg 180 gattatctca ttacatcttc agaagaacat tatgtagtag atattgtgat tatcctcatt 240 ttacagatgg agaaactgag acttagacaa gttaaataac ttgcccaggg ttacaatatt 300 actgagtaga aaaaccacat ttgaacccag gaagtgtggc tgaagaattt ttgtgattta 360 cctgttagac tataattgtc tattttttct acagtggaga taattctggt gtcaaggggc 420 taaagaattt tctcaagacc aaacaacaca ttttttggaa atacgcagta attgaccatg 480 agacatgctg agcttagtac ctcggccgcg accacgctaa gggcgaattc cagcacactg 540 gcggccgtta ctagtggatc cgagctcggt accaagcttg gcgtaatcat ggtcatagct 600 gtttcctgtg tgaaattgtt atccgctcac aattccacac aacatacgag ccggaagcat 660 aaagtgtaaa gcctggggtg cctaatgagt gagctaactc acattaattg cgttgcgctc 720 actgnccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa tcggncaacg 780 cgccggggag aggcngnttg cgtattgggc gctct 815 239 483 DNA Homo Sapien misc_feature (1)...(483) n = A,T,C or G 239 actatgacct gattacgcca agcttggtac cgagctcgga tccactagta acggccgcca 60 gtgtgctgga attcgccctt agcgtggtcg cggccgaggt actttttttt tttttttttt 120 ttttttttta gcgagcaagt atggnttatt acggacaaat ggtagaaaaa tgttactaat 180 atccatagat aagttcctta agtcatgtag agagactgtt attaaaagtt tgctgcattt 240 ttctattgaa tcaagaacta gctaccagtt acagtgcctt ctaaacacac agttagcttt 300 gctttatcaa taaccaaata ataaactagg tcccaatggt tttgtccaca tntagattgt 360 tcaggtgatc aggaactctt ttatttgtgt gctttagctt ttagttcttg gttatatctc 420 caaatacgaa aaagctgaga ggctcctact gcccccacaa agaaattaac agcaaacaga 480 ctt 483 240 815 DNA Homo Sapien misc_feature (1)...(815) n = A,T,C or G 240 gggcctntna gctgctcgac ggccgccatg tgatggatat ctgcagaatt cgccctttcg 60 agcggccgcc cgggcaggta caaccatcca gcaggtccca gaacagtttt cttctgggct 120 ccaattatga aatgggggtt ggtgtgtgct ggattggctg atatggccag acctgcagaa 180 aaacttagca cagctcaatc tgctgttttg atggctacag ggtttatttg gtcaagatac 240 tcacttgtaa ttattccaaa aaattggagt ctgtttgctg ttaatttctt tgtgggggca 300 gtaggagcct ctcagctttt tcgtatttgg agatataacc aagaactaaa agctaaagca 360 cacaaataaa agagttcctg atcacctgaa caatctagat gtggacaaaa ccattgggac 420 ctagtttatt atttggttat tgataaagca aagctaactg tgtgtttaga aggcactgta 480 actggtagct agttcttgat tcaatagaaa aatgcagcaa acttttaata acagtctctc 540 tacatgactt aaggaactta tctatggata ttagtaacat ttttctacca tttgtccgta 600 ataaaccata cttgctcgct aaaaaaaaaa aannnnnaaa aaaaaaagta cctcggccgc 660 gaccacgcta agggcgaatt ccagcacact ggcggccgtt actagtggat ccgagctcgg 720 taccaagctt ggcgtaatca tgggtcatag ctggttcctg tgtgaaatgg tatccgntca 780 caattncaca caacatacga accggaagcc ttaag 815 241 486 DNA Homo Sapien misc_feature (1)...(486) n = A,T,C or G 241 agctatgacc atgattacgc caagcttggt accgagctcg gatccactag taacggccgc 60 cagtgtgctg gaattcgccc ttagcggccg cccgggcagg tacttcccac cactggaaat 120 gttagcataa aagaacttgg agaggaaaaa agtattaaca aaactgcagt ctgcactctt 180 taaacctgtt taaggctctt catcctggtt agcaaaaggt gtgaatgtaa tgtgatggaa 240 tttaaaagtt ttatgagacc aggcacagtg gctcacgact gtaattccag cagtttagga 300 agccgaagtg tgcagatcac ctgaggtccg gagaccagcc tggccaacat ggtgaaaccc 360 tgtctctact agaaatacaa aaattagcca ggtgtggtgg cgggcgcctg taatcccaac 420 tactcaggag gctgaggcta gagaatcact tgaacccagc angcggaggt tgcggtgagt 480 cganat 486 242 481 DNA Homo Sapien misc_feature (1)...(481) n = A,T,C or G 242 anttgacctg attacgccaa gcttggtacc gagctcggat ccctagtaac ggccgccagt 60 gtgctggaat tcgcccttcg agcggccgcc cgggcaggta catcagtgtt cattttatta 120 tttcttacac tgtcttcatg acttacacat aatattttgc tagttttaaa acataagatg 180 tgataataat ctaaacagac caaaggaaat aaatgaatat gattaaaaaa agacagagaa 240 taagccctgt ctgatggaaa gcataacaaa gcaggtagaa caactgtcag gaatgcttga 300 tccaataaag ctaggtttgt gatccacaac acttcagcat tttaatgtga tttttgatgt 360 tngctttttg caatggtgat tctcagttgc ctccctcctg tgtctttaca agctgaaatc 420 aagtgaagct acttctgact ttttctaaaa cttaaaccca acatgaaggt ctgcgtattc 480 t 481 243 824 DNA Homo Sapien misc_feature (1)...(824) n = A,T,C or G 243 cnanngggcc tntnnagcat gctcgacggc cgccatgtga tggatatctg cagaattcgc 60 ccttagcgtg gtcgcggccg aggtacataa tactttagat aaacattttt agaataactt 120 tattataact cgataagcaa aataatccaa acctttatac atttctacaa ggatagtcac 180 atatgtcaat ttttcggttt cctctcgtgc ctattttgtc tcctgagccg gcccctttcc 240 agctgacacg tgtgctccgt gttctcccac aatagtgtga cctggcctga gtccatgccg 300 ccgtgagcct cctttctgtg cttacaacag cagcctgcct gatgtcagtt atggactatt 360 ctttctttca gcctcatttc agggtcctct gcctcttaga gctgctgctg tagcttagct 420 agagacccgc tgctgttgca tcatggaaaa gtgccacata cgtgcacatg tgaaagaata 480 cgcagacctt catgttgggt ttaagtttta gaaaaagtca gaagtagctt cacttgattt 540 cagcttgtaa agacacagga gggaggcaac tgagaatcac cattgcaaaa agcaaacatc 600 aaaaatcaca ttaaaatgct gaagtgttgt ggatcacaaa cctagcttta ttggatcaag 660 cattcctgac agttgttcta cctgcttttg ttatgctttc catcagacag ggcttattct 720 ctgtcttttt taatcatatt catttatttc ctttggtctg tttagattat tatcacatct 780 tatgttttaa aactagcaaa atattatgtg taagtcatga agnt 824 244 483 DNA Homo Sapien misc_feature (1)...(483) n = A,T,C or G 244 actatgacct gattacgcca agcttggtac cgagctcgga tccactagta acggcccgcc 60 agtgtgctgg aattcgccct ttcgagcggc cgcccgggca ggtacgcggg ggcagggtgt 120 ttaatcgtcg ccaagcggga cttactgcaa gctatcaaat ctgaggtctt attttgttga 180 gtcgaaagtg aaattttcct ttggccaacg tgacagggct ttgtttggtg gtaaaaaggg 240 ttactagaca cccctcattc cactgccact ggagggcgca tttctcagct cttgctcttc 300 aaacctgctg aaaggaattc ctagatctaa acaccagcat ttgacattgt gcagcaaana 360 aatggttatg ganaagccca gtccgctgct tgtanggcgg gagtttgtga ggcaatatta 420 tactttgctg aataaagctc cggaatattt acacaggttt tatggcagga attcttccta 480 tgt 483 245 822 DNA Homo Sapien misc_feature (1)...(822) n = A,T,C or G 245 ttgggcccnt nnagcatgct cgacggccgc catgtgatgg atatctgcag aattcgccct 60 tagcgtggtc gcggccgagg tacttcccct cgaaacataa tcggttttgc aattaagatt 120 ctctgaactg gttcagagtc atcaaaaacc acaaaaccaa aatttggaag ctttccccca 180 acacccttgg tattgatgcg aagttccaca acgtttccaa aactcatgaa gaattccttt 240 agctcatttt catcaatatc atgtggcaag ttaccaacaa aaagttgatg actatctgga 300 tagcgaatta ttctacggtt gtcagagtca ttctgttcca tatctcctct gcctggtctt 360 ggtcctctag gaggaaaacc aggtcgttct ctaggtcgtt gttcacgcac acgaggtggc 420 tgagattgaa cttctggttt agcttcgact cttggctttg gtggttcttg tggcagagaa 480 acaggttctg ccggaggagg agtagtagat ttctcctcta gttcttctaa gttcttctcc 540 tccacttgtg gtttcagctc ttcagtcttt gtttcagatt ctggctcagg ttcaggttca 600 tgagaggatt cttccaaagg ctcctctatg ccattagtca cagggtgagc ttcatagtaa 660 ccactgttag cattttcttg cacaggttca ggagatggtt gnctttcttc ttggtcctct 720 tctacttcat cttctgattc ttcatcaaag ttcangctca gaatcaccaa acacttnatc 780 ttcataacga aacatatcat tgtgaacata aaatttattt gg 822 246 482 DNA Homo Sapien 246 actatgacct gattacgcca agcttggtac cgagctcgga tccactagta acggccgcca 60 gtgtgctgga attcgccctt agcgtggtcg cggccgaggt actttttttt tttttttttt 120 aaccaactca atatgtgttt gatgatagtg aattgataaa acccgaagct tttccctgta 180 aatcttacat ctttgccttt aaagaatggg ttacaaccat cactagatca cagtagtgcc 240 taatgaaggt tgagaaccgt aggagaggct ctcatgctgt aaataatgtt gcaggctaat 300 aacctttcat cacttccttt gtgcgcttcc tgccttaagt gacaagtagc aacatggctt 360 gggtcccctg tgcagcatca gcttatgctg ccacaagtca gtttgcaccc taggtgccca 420 ggagctagta tccttagatc tttctatcgc taacttaatt ctcttcgtta tttatctgac 480 cc 482 247 816 DNA Homo Sapien misc_feature (1)...(816) n = A,T,C or G 247 gggccttnga gctgctcgan cggccgccat gtgatggata tctgcagaat tcgccctttc 60 gagcggccgc ccgggcaggt actttaattt tgcttgttca aatgatctac acttacattt 120 tgcaaatctt ttttttaaat tttttaaatt ttatattttt tttccagcca actcaaggcc 180 aaaaaaaatt tcttaatata gttattatgc gaggggaggg gaagcaaagg agcacaggta 240 gtccacagaa taagacacaa gaaacctcaa gctgtgaggt caatttgtaa ttaaaagaat 300 actaagatta gatgaacaca acactcagaa atactctagg agggctgaaa aagaaggaac 360 agatgttaac aaaacaaatt aaggctgctg gggaacctga gtccatgtta agcttgggtt 420 gactgtaaag aatttttttt tttttaatgc aagttagaca tggagttaga gggtcagata 480 aataacgaag agaattaagt tagcgataga aagatctaag gatactagct cctgggcacc 540 tagggtgcaa actgacttgt ggcagcataa gctgatgctg cacaggggac ccaagccatg 600 ttgctacttg tcacttaagg caggaagcgc acaaaggaag tgatgaaagg ttattagcct 660 gcaacattat ttacagcatg agagcctctc ctacgggtct caaccttcat taggcactac 720 tgngatctag tgatggttgt acccattctt taaaggcaaa gatgtaagat ttacagggaa 780 aagcttcggg ttttatcaat cctatcatca acacng 816 248 482 DNA Homo Sapien 248 actatgacct gattacgcca agcttggtac cgagctcgga tccactagta acggccgcca 60 gtgtgctgga attcgccctt tcgagcggcc gcccgggcag gtactctttg ggcattaatg 120 ccttctctgt aattatatct cgtttttgct tggcagtgac ctacccagta attgcatcgt 180 gtattgccat gaaaggtaaa cacattgtga actgaactta ccaagcagat tctgtgagaa 240 agcactggtt ggggctgaac actgttgaca catcattttt attggaagag tattaactgg 300 tgcctcttct gaaacacacc aacccatatt cctctgctcc cccaaagctg tttctgatcc 360 tgctgggagc aactaactag ttattatgca catctgctcc agacccagct ctttaacttc 420 atggttttac agcttgtttt ttctttttct tttcttttct ttttttttaa aaaagcacct 480 tt 482 249 821 DNA Homo Sapien misc_feature (1)...(821) n = A,T,C or G 249 ggcctctnag ctgctcgacg gccgccatgt gatggatatc tgcagaattc gcccttagcg 60 tggtcgcggc cgaggtactt tatgaatttg gggtaggtaa agtttgtatt ttatcttaaa 120 catgttttct atgatgaaaa ggaacaaaat tgtaaaaaat gaggatcttc cctctaaagg 180 tttcaaagcg ttagaggaca tgcaattaaa tgttgttaca ccttgaacaa tgagcctctt 240 gagtttgtag gaagggcaga ccggctccat taccaacaac tttggggtag aaagcacagc 300 tctcctcttt tacccagcac aaatgcaatc ctgattataa aactatttgt gtttctaaat 360 acaaccaaag gaaatcttag agaaacataa attagaaacc tcttttatta aggggaaaca 420 acaaaaaaag gtgctttttt aaaaaaaaag aaaagaaaag aaaaagaaaa aacaagctgt 480 aaaaccatga agttaaagag ctgggtctgg agcagatgtg cataataact agttagttgc 540 tcccagcagg atcagaaaca gctttggggg agcagaggaa tatgggttgg tgtgtttcag 600 aagaggcacc agttaatact cttccaataa aaatgatgtg tcaacagtgt tcagccccaa 660 ccagtgcttt ctcacagaat ctgcttggta agttcagttc acaatgtgtt tacctttcat 720 ggcaatacac gatgcaatta ctgggtaggt cactgccaag caaaaaccga agatntaatt 780 tcccgagaag gcattaatgc ccaaagagta cctgccccgg n 821 250 481 DNA Homo Sapien 250 acttgacctg attacgccaa gcttggtacc gagctcggat ccactagtaa cggccgccag 60 tgtgctggaa ttcgccctta gcgtggtcgc ggccgaggta caacattgat gttttaatat 120 agaatgaagt gcttgctaca cagtcaagta aatcaacata tccattacca cacacacttt 180 tcttttctga ggagcggtaa gagtacttta attttgcagt tattgattaa ttaaaaaaca 240 cagttgtttt cagcatttcc tagttacagt agtgcatagg aaattccatt ctaaacaaag 300 aagtaattaa tgaaataaca acacacctta acattttaca ttgataggtt acagtttaca 360 aggtgctttc acatacatta tttcatttga ttcttacaac aagcagaaaa aacagtggga 420 aagatttttt ttttcaggct tacaatgagt attttcaggc caatgggcag ttaacacaag 480 g 481 251 803 DNA Homo Sapien misc_feature (1)...(803) n = A,T,C or G 251 gggccttnna gctgctcgnc ggccgccagt gtgatggata tctgcagaat tcgccctttc 60 gagcggccgc ccggcaggta cactaaatta gaatattttt aaagtatgta acattcccag 120 tttcagccac aatttagcca agaataagat aaaaacttga ataagaagta agtagcataa 180 atcagtattt aacctaaaat tacatatttg aaacagaaga tattatgtta tgctcagtaa 240 ataattaaga gatggcattg tgtaagaagg agccctagac tgaaagtcaa gacatctgaa 300 tttcaggctg gaaaactatc agtatgatct cagcctcagt tctcttgtct gtaaaatgga 360 agaactggat taggcagttt gtaagattcc tcctaacttt cacagtcgat gacaagattg 420 tctttttatc tgatattttg aagggtatat tgctttgaag taagtctcaa taaggcaata 480 tattttaggg catctttctt cttatctctg acagtgttct taaaattatt tgaatatcat 540 aagagccttg gtgtctgtcc taattccttt ctcactcacc gatgctgaat acccagttga 600 atcaaactgt caacctacca aaaacgatat tgtggcttat gggtattgct gtctcattct 660 tggtatattc ttgtgttaac tgcccatggc ctgaaaatac tcattgtaag cctgaaaaaa 720 aaaatctttc ccactggttt ttctgcttgg tgtaagaatc aaatgaaata tggatgtgaa 780 agcccttgta actgtaccta tcn 803 252 500 DNA Homo Sapien misc_feature (1)...(500) n = A,T,C or G 252 tacnccaann tttgacctga ttacgccaag cttggtaccg agctcggatc cactagtaac 60 ggccgccagt gtgctggaat tcgcccttag cgtggtcgcg gccgaggtac agatgaaaag 120 aagtggtgtt aatgacctac ctgcaccgat aataaagcaa atagaatgat tatatacatt 180 aagatcagct tgattaaaaa taaattttat atgcaggtaa attgatcatt aaaatgaacc 240 cagtttaact cttctcgtgt gttgttttaa ggtaggccac tgaaacgcag agataaaatc 300 anatggggaa aattaaaagc naagaaaaaa attacaaaac aagtgggtta agccatggat 360 tcttaaccaa accctggact aaatgtgcca aagtgctttg aaaatttcca ctgccagcna 420 tggntggtaa agtcantttg gcaaaaaaaa ggtggttnga aaaaaaactn accttttaaa 480 ttcccacctt ggatctggcn 500 253 831 DNA Homo Sapien misc_feature (1)...(831) n = A,T,C or G 253 gnnnnnnnnn gnnnnnnnnn ntttnnantg ggcctctnna gcatgctcga cggccgccat 60 gtgatggata tctgcagaat tcgccctttc gagcggccgc ccgggcaggt actatatttg 120 tgagcctagg gtaggggcac tgctgcaact tctgctttca tcccatgcct catcaatgag 180 gaaagggaac aaagtgtata aaactgccac aattgtattt taattttgag gtatgatatt 240 ttcagatatt tcataatttc taacctctgt tctctcagta aacagaatgt ctgatcgatc 300 atgcagatac aatgttggta tttgagaggt tagttttttt tcctacactt ttttttgcca 360 actgacttaa caacattgct gtcaggtgga aatttcaagc acttttgcac atttagttca 420 gtgtttgttg agaatccatg gcttaaccca cttgttttgc tatttttttc tttgctttta 480 attttcccca tctgatttta tctctgcgtt tcagtggcct accttaaaac aacacacgag 540 aagagttaaa ctgggttcat tttaatgatc aatttacctg catataaaat ttatttttaa 600 tcaagctgat cttaatgtat ataatcattc tatttgcttt attatcggtg caggtaggtc 660 attaacacca cttcttttca tctgtacctc ggccgcgacc acgctaaggg cgaattccag 720 cacactggcg gcccgttact agtggatccg agctcggtac caagcttggc gtaatcatgg 780 gtcatagctg tttcctgtgt gaaattggta tccgntcaca attcccacan g 831 254 514 DNA Homo Sapien misc_feature (1)...(514) n = A,T,C or G 254 cacttgacnt gatcgccaac ttggtaccga cntcgnntcc attattaccg gacacttgac 60 tgatacgcca ncttggtacc gactcggacc actagtaacg gncgccagtg tgctggaatt 120 cgcccttgag cggccgcccg ggcaggtacc tctaatgcag gctaataaat ttaagctaat 180 tatttatgct acctgtgctg tggtggtttc ctatcagcag ccaaatataa cctcacagtt 240 gttttgctgt ttttgctttc acaaaagagc tattaaccaa cttaaaaatg ttttttgatt 300 gaaggatgct taggggatga gaggatatca acaatataag cccatgccaa atccccattt 360 cttatcatta aaactgacct gacattaaag caatgcttaa ttttttacca taagagtgaa 420 attttgagat tataatttta aagtgtaaaa tatttacact taaattacac ttataatttt 480 aaagtgtata atatttacac agattaaaat aaaa 514 255 830 DNA Homo Sapien misc_feature (1)...(830) n = A,T,C or G 255 nnnnnngncn nnnnnnannn nnnnnnnant gggcctctnn agcntgctcg acggccgcca 60 tgtgatggat atctgcagaa ttcgccctta gcgtggtcgc ggccgaggta cttttttttt 120 ttttccagat gaagtcttgc tctgttgccc aggctggagc gcagtggcac aatctcagct 180 cactgaaacc ttcgccccct gggctcaagc tagccagtct tttagtaaac atttagtcaa 240 caaatctgca attataacgg aggtttgatt tttgttgttt ttgtttgttt ttaagtcact 300 ctgtgtttgt aatatcaatt tacttttcaa gtttagaatg ttttgcttca ttgtttccca 360 tattttattt taatctgtgt aaatattata cactttaaaa ttataagtgt aatttaagtg 420 taaatatttt acactttaaa attataatct caaaatttca ctcttatggt aaaaaattaa 480 gcattgcttt aatgtcaggt cagttttaat gataagaaat ggggatttgg catgggctta 540 tattgttgat atcctctcat cccctaagca tccttcaatc aaaaaacatt tttaagttgg 600 ttaatagctc ttttgtgaaa gcaaaaacag caaaacaact gtgaggttat atttggctgc 660 tgataggaaa ccaccacagc acaggtagca taaataatta gcttaaattt attagcctgc 720 attagaggta cctgcccggg cnggccgtca agggcgaatt ccagcacact ggcggccgtt 780 ctagtggatc cgactcggtc cagcttgcgt aatcatggtc atagctgttg 830 256 524 DNA Homo Sapien misc_feature (1)...(524) n = A,T,C or G 256 cnnnnnnnna ncntnanacn nnnnnntngn nnnnnagnnn nnnnnnnnnn nnnnnnnnan 60 actatgactg attacgccan cttggtaccg actcggatcc actagtaacg gccgccagtg 120 tgctggaatt cgcccttagc gtggtcgcgg ccgaggtaca ttacttggtg ttaacattgt 180 tggcagtggt agcccctttt cagaaagcaa cttgctgtaa gtcagggtgt ccgttccaac 240 cttcagccag tgaaaaggta gtaacaaatg gtaaacaaga gaatgattgt ttaaacctat 300 ctgtggacac ttaatgcaac tgtttaaaaa tgataatcac gagttatgta gcaacgtgga 360 aatatattta cagaacatta agtggagaaa gcaggacacg aaagtatatt tatactacag 420 ttataactca acagttcatt tatatgctgn tcatttaaca gttcatttaa acagttcatt 480 ataactgttt aaaaatatat atgcttatag tcaaaagctg ttgg 524 257 814 DNA Homo Sapien misc_feature (1)...(814) n = A,T,C or G 257 ntgggcctct agaagcatgc tcgagcggcc gccagtgtga tggatatctg cagaattcgc 60 ccttgagcgg ccgcccgggc aggtactttt tttttttttt tttttttttt tttgatattt 120 atttttaact ttatttttat tgntgacact attacagata gaatgaccac aaccatatta 180 acaaaccaaa aacctgtgca cagaaacaag atgaagaaaa tatatcaaga tgttaaccac 240 actctttgga tggtgaaaac atgggtgagt ttctcttcta catttctgta acttcaaagt 300 ttctataatg aacacatttc atatataatg gaaatatatg tagtaaaggt ggactaccaa 360 aacactagaa tgatgacctt tcaaggaaac cgaaacaaaa taaccataat cccacaacaa 420 ccacacaact atttcttgct tttcatcttt cttcccatct ttgacattta tgcatactta 480 tcactaacac cctaataatc acagactagt gcacagatca agatgttaac agttaattgt 540 tgttgggtgt tgggaatatg tgtgaatttt ctttactgaa tttccaaagt tttgtatgag 600 tatgtattat atttgtaatg gaaaatacat acataaaatt tattaccaaa acaccaaaga 660 ttatttaagg aatttgagac aaaatattta accaaattcc cacaatgaca acactatttt 720 agttattttc cacatctttt catttaaaga ctttatgcac acatatttaa cactgntatc 780 acaagcgtgt gcactgnaac aggattgagg aaan 814 258 474 DNA Homo Sapien misc_feature (1)...(474) n = A,T,C or G 258 acagctatga cctgattacg ccaagcttgg taccgagctc ggatccacta gtaacggccg 60 ccagtgtgct ggaattcgcc cttagcgtgg tcgcggncga ngtacattat ttggaggact 120 taaaatctgn atgtggacat ggtcccaact tantgtccgt taactagtta tccaaattgt 180 aanagctaca gaaagcccag ttgaggggta antgtgcctg gntcacacag cctgcaccct 240 gtcacctcgg caatgagcca gtgtggggca ctggggactt ctaacccttg gattgctctt 300 tttgacctgt gcataccttc taattgnaaa atatatttca gaccgagagt acntgcccgg 360 gcggccnctc aaaagggcga attctgcaaa tatccatcac atggcggccg ntngagcatg 420 catctaggag ggcncaattc ccctatagng agtngtatta caattcactg gcnc 474 259 809 DNA Homo Sapien misc_feature (1)...(809) n = A,T,C or G 259 ntgggcccnt agangcatgc tcgncggccg ccatgtgatg gatatctgca gaattcgccc 60 tttcgagcgg ccgcccgggc aggtactcac ggtctgaaat atattttaca attagaaggt 120 atgcacaggt caaaaagagc aatccaaggg ttagaagtcc ccagtgcccc acactggctc 180 attgccgagg tgacagggtg caggctgtgt gagccaggca cacttacccc tcaactgggc 240 ttctgtagct ttacaatttg gataactagt tagcggacag tagttgggac atgtcacata 300 cagatttgag tcctccaata atgtacctcg gccgcgacca cgctaagggc gaattccagc 360 acactggcgg ccgttactag tggatccgag ctcggtacca agcttggcgt aatcatggtc 420 atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg 480 aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt 540 gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg 600 ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct cgctcactga 660 ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctactcaaa ggcggtaata 720 ccgttatnca cagaatcang ggatacgcag gaaagaacat gtgagcaaaa ngccacaaaa 780 ggccaggaac cgtaaaaagg ccgcgtttg 809 260 713 DNA Homo Sapien misc_feature (1)...(713) n = A,T,C or G 260 ctctttaaac gccagctcga ntccganntc tatccntgac aannnnngtn ccggnctgga 60 attcgncctt tcgagcggcc gcccgggcag gtacttgagt tcatgggcat ctctcccgcc 120 gcctctcagc ctatctgcac catgtctcac acgttcagtt gcagctctta ccgttttgaa 180 ggcgcacgtg ggcaagaagt cctgggcagc acaagaaagt caatcacgtt gagacagaga 240 gagcaggaga ggaagtgggc cccagtagaa gtgggcgaga gagcgttggg tgggaacgtg 300 gcacgagaga gagaaattat gagattgaga gagagagaga gagagagaga gagagagaga 360 gaaagagana ganagaggga aaganaaaga gacagagaaa agaaactatt gttggttaaa 420 atgccagcgg aaagtccatg ggggtgaatg agtccggcaa tggncangga gttagcagct 480 tggcgtagtg tctttcactg ntttggctgt cttgagaata gcattcnacn ccgactgtgg 540 ttccccanca gactttagnc ngttgcccng ncttgaattg ccggaccaag gttaacatag 600 gcttttcggn tctnaatatt tttggggctn gaatantcgg aaccntttgg gctgggccat 660 ttacccgntn cnncntgggt nnnacatttt tnctggntaa tcccgccttt tng 713 261 722 DNA Homo Sapien misc_feature (1)...(722) n = A,T,C or G 261 acgcanttag gtaccgagct cggatcccta gtaacggccg ccagtgtgct ggaattcgcc 60 cttagcgtgg tcgcggcccg aggtactcct cagccatgcc gaaggtcctc ttccgggact 120 cttcgatggc agacagcagg gcattgtcct tctcattctt caggaagccc tgcagctctt 180 aaatttaagg agttacagaa cggtcgatgc tgncgatcac tgcagctctt ccaaaccttc 240 ttatatgaga tgagctctgt cggaaccagt gctcaagttt ttcccacccc aaactgcctg 300 aattgaggga tgggggtggg gagaaggaca gagagaagag aaaaagagag aaagaagana 360 aaggaaaaga acaacccctc tgcaagtgct gatgtgactg aagcactaaa gagtcaaatt 420 aaacaatgaa gattgcaggg tccctttaaa aagggtgcac tgcagncccc ngagcacanc 480 natcccattc gnttgngccg ctncacanat tctagagaan tcnnccatca tgtttgaaan 540 gcncaaaant gatgggannt cccgnntacg cggggactta attctgcctt gggaaatcaa 600 ggaanacttt gnttggangc ggcanttnaa anntggcctt aagaangnng tgngaatttg 660 ttggccaaac nantngaaag gtnttccggc cgatnggtcc ctgattttta aggattnnaa 720 ng 722 262 705 DNA Homo Sapien misc_feature (1)...(705) n = A,T,C or G 262 acgctttaaa cnccagcttg gtaccgagct cggatcccta gtaacggccg ccagtgtgct 60 ggaattcgcc cttgccgccc gggcaggtac ctgatatttt gaacttttaa ttgctatcaa 120 atttcagctc tggttttatg cattgttgta atttctcagt gaatcccagt gcttctttcc 180 ttcttgaaaa atgccatttc gcccaggcgc ggtggctcat gcttgtaatc ccagcacttt 240 ggtaggccga ggtgggtgga tcagctgagg tctgtagttc aagaccagcc tggctaacat 300 gatgaaaccc tgtctctacc aaaaatacaa aaaaaaacta gccaggcatg gtgttgtatg 360 cctgtaatcc cagctactca ggaggctgag acaggagaat cgcttgaacc tgggaggtgg 420 aggttgcagt gagccaagat cgcgccactg cactncaacc tgggcaacag agtgagactc 480 catctcaaaa naannaaaaa ggaaaatgcc atttcttggg cccantgcca atatgcacca 540 agaatgttng taggaactac tttggtctgg ctgcagaagt tcttaatcta gcattaaaaa 600 tccaacggtt gatttgatct cttaaaatgg ttttcnnant ttgganctga aattgagnat 660 aaattacctt tgcnnntnaa ttcaaaangt tnaacctnnt tnann 705 263 656 DNA Homo Sapien misc_feature (1)...(656) n = A,T,C or G 263 acncgcttgt accgagctcg gatccctagt aacggccgcc agtgtgctgg aattcgccct 60 tagcgtggtc gcggcccgag gtaccgcggg ggagaacgcc agggagctgt gagagtgtgc 120 agtcgcgttc ctgctgtccg gacacttttt tcctctactg agactcatct ggtagatccg 180 caggccagtc ctcccagggg ctgaagttgt gaaatatggg ttttctaaga agattaatct 240 atcggcgtag accaatgatc tatgtagaat cttctgagga gtccagtgat gagcaacctg 300 acgaagtgga atcaccaact caaagtcagg attctacacc tgctgaagag agagaggatg 360 agggagcatc tgcagctcaa gggcaggagc ctgaagctga tagccaggaa ctggttcagc 420 caaagactgg gtgtgagctt ggagatggtc ctgataccaa gagggtntgc ctgcgaaatg 480 aagagcagat gaaactgccc gnagaaggcc agacctgann cgatagcagg acagttcccc 540 gaaactggtg tagcgcgaat gtctgtgtca gagtggcctg ccaatcaagg agtgaaccct 600 gggaataagc atccagctta aagannccct ganggttagt gtctngtgaa ttncct 656 264 752 DNA Homo Sapien misc_feature (1)...(752) n = A,T,C or G 264 ggnttgaang tatacgactc nctanggcga attgggccct ctagatgcat gctcgagcgg 60 cccgccagtg tgatggatat ctgcagaatt cgcccttagc gtggtcgcgg ccgaggtacc 120 tttgataatt cctagacctc tattttcatt ctgtgtatta atgtgaataa cagatggata 180 ttttaatatt taaggcagat ggtaaacttt cctataggtc ttgtgagact tcgtcttata 240 ggctgaacac cattcacaaa atgtaataat gcttcattcc ttcaggttga ggtaaagaac 300 ttgagcaact ggattagcaa agctgcaaag aatgaaatgt ggcctaagat gtaattatgt 360 tctctgccct tcctttgggc cagggtagtt ttgcacttga cacaatggaa aataggccat 420 aaagcctgaa aataaaatgt tctaaacccc aatctcacag cactttagta ggcttttcac 480 taggcatctt taaagtattt tcaacaaaat actaattaag ctaccacttc aaaagagctt 540 caaggaaaag ctctgctttc ttataaaatc tttttgagac agagtttccg ctcttgtcag 600 cacaggctgg agtgcaatgg ccgtgatctc gactnaaccg naaccttcgg cctgctgggt 660 tcaagtgatt ctctagncct caagcttctg agtaggttgg gattacaggc gcccggncaa 720 ccacacctgg gctaaatttt ggatttctan gn 752 265 747 DNA Homo Sapien misc_feature (1)...(747) n = A,T,C or G 265 gngntttcnc nnngcgctct anagcatgct cgagcggccg ccagtgtgat ggatatctgc 60 agaattcgcc cttagcgtgg tcgcggccga ggtacctttg atnattccta gacctctatt 120 ttcattctgt gtattaatgt gaataacaga tggatattgt aatatttaag gcagatggta 180 aactttccta taggtcttgt gagactncnt cttataggct gaacaccatt nacnanntgt 240 antaatgctt nattccttca ggcngaggtn nanaacttga gcacctggat tagcagcagc 300 tgcgaagaat gaaatgcngc ctaacatgta attatgnatc tctgnccttc ctttgggcca 360 gggtagtnat gcnctagaca cantggatga tangccatna agcctgannn tgnaatgatc 420 taaacccnaa tctnncagca ctttattagg ctantcacta ggcatcttta agagtnggtt 480 cccnttaata ctagncaacc nnccactcca aaanancttc aagganaagc tntgntntnt 540 tanaaaatct tttcgnnaca cantttnacn cttggcgcnc angctggant gcaatggccg 600 tgatctctac tcacccgaan cctcngactg ctgagttcaa gtgattgtct gnccttanct 660 ctccgggacc angnttnggg attancaagc ctcgcgggca annacaggtg nctaattgnt 720 tgcattngcn taaaatnagg acaccng 747 266 738 DNA Homo Sapien misc_feature (1)...(738) n = A,T,C or G 266 cgnnnntgaa ggntacgact cactataggg cgaattgggc cctctagatg catgctcgag 60 cggccgccag tgtgatggat atctgcagaa ttcgcccttt cgagcggccg cccgggcagg 120 tacagctgaa gtttgataac aaagaaatat atataagaca aaaatagaca agagttaaca 180 ataaaaacac aactatctgt tgacataaca tatggaaact ttttgtcaga aagctacatc 240 ttcttaatct gattgtccaa atcattaaaa tatggatgat tcagtgccat tttgccagaa 300 attcgtttgg ctggatcata gattaacatt ttcgagagca aatccaagcc attttcatcc 360 aagtttttga catgggatgc taggcttctg gtttccattt gggaaatgta ttcttatagt 420 cctgtaaaga ttccacttct ggccacactt cattattggg agtgcccaaa gctctgaaat 480 cctgaagagt tgatcaattc tgaatcccat ggaaaagtgg ttcttagtgc tagtcaacaa 540 atatnggngc ctatactcca aaggtcactt ggagttgagt natggagctg accccagcat 600 acttttggaa aactggacca agtggttgca ccaccnttaa aaaatttaaa accggnngta 660 ttttaaataa ggtggaagaa accttttcct tttttattta aggaattcac ttagcnctta 720 ctaaattcat ggtggggg 738 267 731 DNA Homo Sapien misc_feature (1)...(731) n = A,T,C or G 267 gngnntttgn aagggccctc tagatgcatg ctcgagcggc cgccagtgtg atggatatct 60 gcagaattcg ccctttcgag cggccgcccg ggcaggtaca gctgaagttt gataacaaag 120 aaatatatat aagacaaaaa tagacaagag ttaacaataa aaacacaact atctgttgac 180 ataacatatg gaaacttttt gtcagaaagc tacatcttct taatctgatt gtccaaatca 240 ttaaaatatg gatgattcag tgccattttg ccagaaattc gtttggctgg atcatagatt 300 aacattttcg agagcaaatc caagccattt tcatccaagt ttttgacatg ggatgctagg 360 cttcctggtt tccatttggg aaatgtattc ttatagtcct gtaaagattc cacttctggc 420 cacacttcat tattgggagt gcccaaagct ctgaaaatcc tgaagagttg atcaatttct 480 gaatccccat ggaaaagtgg tttcttagtt gctagttcag caaatatggt gcctatactc 540 caaatgtcaa ctggagttga gtaatgagct gaccccagca atacttctgg agatctgtca 600 agtggttgca acaccattaa aaaatataaa agcagtagtt atattaaaat aatgttgaag 660 aaaacatatn cctatatatt tnaaggaatt tcactaagca ctactaaatt tcatgttgtt 720 gggangngtt a 731 268 745 DNA Homo Sapien misc_feature (1)...(745) n = A,T,C or G 268 gnnnnnntaa agnanacntc actatanngc gaattgggcc ctctagatgc atgctcgagc 60 ggccgccagt gtgatggata tctgcagaat tcgccctttg agcggccgcc cgggcaggta 120 cttcccacac aggtttgttg taaaaattaa gtgagctaat gtgtataaaa tacttcagtg 180 ctgaataaat gttggctttt attatatatt gttaaaaaac aacacaggct gggtatgata 240 gctcacgcct ataatcctag catttaggga ggccaaggca ggaggattgc ttgagtccag 300 gggtttgaga ccagcctggg caacatagtg agaccctatc tctacaaaat aaaataaatt 360 agttgggcat ggtggcacat gcctgtagtc ccagctactc aggaggctga ggtgggagga 420 ttgcttgagc ccaggaggta gaggttgcag tgagctgtga tcacaccact gcactccagc 480 gtcggtgacg gagtgagaac ctatctcaaa caaacaaaca aaaaaaccca aaacaaacaa 540 aaaaatccag taaagacaga gattcctaaa attctacaat tctaaaaacc agtagggctc 600 actgaatata agagaggcaa gcaaaaaatt actccaatat tttgagtttg ggtaacctgg 660 aatatgggtc atttattgag taaatagtta ctgagtccta actatgtgcc acacactggg 720 ttaacacttg gcactgtctc ttatg 745 269 730 DNA Homo Sapien misc_feature (1)...(730) n = A,T,C or G 269 gntnnnnttt tnaanccggt cctnntgcat gctcgagcgg cccgccagtg tgatggatat 60 ctgcagaatt cgccctttga gcggccgccc gggcaggtac ttcccacaca ggtttgttgt 120 aaaaattaag tgagctaatg tgtataaaat acttcagtgc tgaataaatg ttggctttta 180 ttatatattg ttaaaaaaca acacaggctg ggtatgatag ctcacgccta taatcctagc 240 atttagggag gccaaggcag gaggattgct tgagtccagg ggtttgagac cagcctgggc 300 aacatagtga gaccctatct ctacaaaata aaataaatta gttgggcatg gtggcacatg 360 cctgtagtcc cagctactca ggaggctgag gtgggaggat tgcttgagcc caggaggtag 420 aggttgcagt gagctgtgat cacaccactg cactccagcg tcggtgacgg agtgagaacc 480 tatctcaaac aaacaaacaa aaaaacccaa aacaaacaaa aaaatccagt aaagacagag 540 attcctaaaa ttctacaatt ctaaaaacca gtagggctca ctgaatataa gagaggcaag 600 caaaaaatta ctccaatatt ttgagtttgg gtaacctgga atatggtcat tattgagtna 660 atagttactg agtcctacta tgtgcccaca ctgggtnaac acttgcactg tctcttatga 720 aatcttccan 730 270 713 DNA Homo Sapien misc_feature (1)...(713) n = A,T,C or G 270 aattgggccc tctagatgca tgctcgagcg gccgccagtg tgatggatat ctgcagaatt 60 cgccctttcg agcggccgcc cgggcaggta caaaccaata gctcctattc tggaaggttt 120 tctttttatt taaaaaaaat tcaaacaagg ttaaaagtca agcaagaagg gaagagagaa 180 actgggttct gagaaaaaaa tgtgccagta taaaataaac tcctaaatgc gtgcttgtca 240 tcctctagtt ttttttttaa gttgaatttc ttttccactg taacttaaga tttgagattg 300 aggtttgcgg tccagaacat accctcagca gatacagtga ctaactggaa agtgcagttg 360 ttcaaggtct gtcatgctca atcacctaaa gctataattt gnttgatata ttaagcatgt 420 agacctagtg cagcatggga gccactcagg aagtttatgc aattaataaa ctttcagcat 480 aatttactat gaagtatgca gaatttcacc ctcttctcca cacttaacat ttagttgtat 540 atgtgaactc tcctttctta attggggaat gtagcattat atagaatgtt gntaaaggta 600 attttaatcc tttttgacat taaccttttt tttttttggn aaaccaagtg atctgccttt 660 cagcaactgg cttattttgg gtctttgaaa ctgngatttt tatttcattn gnc 713 271 702 DNA Homo Sapien misc_feature (1)...(702) n = A,T,C or G 271 gnctcgagcg gccgccagtg tgatggatat ctgcagaatt cgccctttcg agcggccgcc 60 cgggcaggta caaaccaata gctcctattc tggaaggttt tctttttatt taaaaaaaat 120 tcaaacaagg ttaaaagtca agcaagaagg gaagagagaa actgggttct gagaaaaaaa 180 tgtgccagta taaaataaac tcctaaatgc gtgcttgtca tcctctagtt ttttttttaa 240 gttgaatttc ttttccactg taacttaaga tttgagattg aggtttgcgg tccagaacat 300 accctcagca gatacagtga ctaactggaa agtgcagttg ttcaaggtct gtcatgctca 360 atcaccctaa agctataatt tgtttgatat attaagcatg tagacctagt gcagcatggg 420 agccactcag gaagtttatg caattaataa actttcagca taatttacta tgaagtatgc 480 agaatttcac cctcttctcc acacttaaca tttagttgta tatgtgaact ctcctttctt 540 aattggggaa tgtncattat atagaatgtt ggtaaaggta attttaatcc tttttgacat 600 taaccttttt ttttttttgg taaaccaagt gatctgnctt ttaacaactg gcttatttgg 660 gtcctttgna actgggaatt ttatttcatt tgnncctcgg cc 702 272 736 DNA Homo Sapien misc_feature (1)...(736) n = A,T,C or G 272 gnnntttgan nnnnnnnnnn ntatagggcg aattgggccc tctagatgca tgctcgagcg 60 gccgccagtg tgatggatat ctgcagaatt cgccctttcg agcggccgcc cgggcaggta 120 ctttttttta ttcctcagtt aaaacatgcc tgttattctt tttgtaatac ttaagcaatt 180 ttattttaaa gatatactac ttagttcatc cgtctccact tgtttttttt ttttgnnant 240 anngggttgg ttccnttaan nccacnggtt ttaaanccat nntngtcnnn ggnaaattan 300 nnttantnat taaanntnnn tnncntngca aanntccagn taaaatttta gtgggggggg 360 ggggttantt acnggnaann aattaantnc nggnnaatan tttaannntt ggnaangnac 420 nntngnnnta annattattt nnttnanntt tttaataann annaatttta ntttgnaacn 480 ntggtnttta ntaannggaa annccaatta attggttggt tgnatttttc ccagnaaccn 540 ntccntgggc nggaacnncc ntangggnaa nttcnagnnn ntngngggcn gtncnnaggg 600 nnnccaacnt nggcccancn tggnggaann nnnggcnnna nnggttcccn ggggnaaatg 660 gtattcngtt cnaatccnnc aanttccaac ccggagnctt aangggtaan nccngggggg 720 cntanngagn gcctaa 736 273 715 DNA Homo Sapien misc_feature (1)...(715) n = A,T,C or G 273 gngntttnac ganngnnnnn nnnnnctgct cgagcggccg ccagtgtgat ggatatctgc 60 agaattcgcc ctttcgagcg gccgcccggg caggtacttt tttttattcc tcagttaaaa 120 catgcctgtt attctttttg taatacttaa gcaattttat tttaaagata tactacttag 180 ttcatccgtc tccacttgtt tttttttttt gnnantanng ggttggttcc nttaanncna 240 cnggtnttaa anccannnnn gtcnnnggna aattannntt antcnntaaa nntnnnnnnc 300 ntggnaannn tccagntaaa atttnagtgg gggggggggg ttaattancg gnaannantt 360 aantnccgga naatanttta annnttggna angnacnttn gnnntaagna ttatttnntt 420 cannttttta atnantanna attttaattt gnaancntgg nntttannaa nnggaaannc 480 caattaattg gttggttgna tttttcccag naaccnnncc ntgggcngga acanccntaa 540 ggncaaatcn accaantgnc ggccgtacna aggggatcca acntnggccc ancctggnng 600 naataatggc cnaantggtt nccngggnna aatggnattc cgttcaaatt ccnccanntc 660 cnacccggag ccttaagngg taaacctggg ggcctaangg ggggcctaac tcaat 715 274 746 DNA Homo Sapien misc_feature (1)...(746) n = A,T,C or G 274 gnnnntnnan gnntacgact cactataggg cgaattgggc cctctagatg catgctcgag 60 cggccgccag tgtgatggat atctgcagaa ttcgccctta gcgtggtcgc ggccgaggta 120 ccaggtgggc tgacgcacat cccctaaaca ttctggatct cttactcatc gtgaaaggca 180 gacgctctaa gtctaaagtc tagggtagga gtttccattc tttggaaaac caaagatggt 240 tactcttctt aatgaaactg agaagaaggt atctacagaa aacactgaat ttaaacaaat 300 tatgaccttg tttgttgaag ccatcaagga cccaagatat atcaaagaac aacatctctg 360 tattggccta caggttcaga gtgttttgag gtctgtttaa gcactaatag gattttaggc 420 cagcatccag tcagaagaga tagttcacag actcagagtt ggaaacagat taaaaaaaaa 480 aagatgtcaa catagaaaat gatgatagag tttagttaaa aaaattcaca cataaaatta 540 cagttaaaaa aattcacaca taaaatagag tgtttgcata gcaagacatt attgcccttc 600 agcctggcag aaaaacataa actcaggtgt atattttata ataaacattg nattgaatgc 660 taagaatgat acactggtga acatctnctg aatggttgcc ttcttgtaaa tcataccaat 720 tggttagaca attgaaattn ccagct 746 275 725 DNA Homo Sapien misc_feature (1)...(725) n = A,T,C or G 275 gnnnttaann ccttccctnt anatgcatgc tcgagcggcc gccagtgtga tggatatctg 60 cagaattcgc ccttagcgtg gtcgcggccg aggtaccagg tgggctgacg cacatcccct 120 aaacattctg gatctcttac tcatcgtgaa aggcagacgc tctaagtcta aagtctaggg 180 taggagtttc cattctttgg aaaaccaaag atggttactc ttcttaatga aactgagaag 240 aaggtatcta cagaaaacac tgaatttaaa caaattatga ccttgtttgt tgaagccatc 300 aaggacccaa gatatatcaa agaacaacat ctctgtattg gcctacaggt tcagagtgtt 360 ttgaggtctg tttaagcact aataggattt taggccagca tccagtcaga agagatagtt 420 cacagactca gagttggaaa cagattaaaa aaaaaaagat gtcaacatag aaaatgatga 480 tagagtttag ttaaaaaaat tcacacataa aattacagtt aaaaaaattc acacataaaa 540 tagagtgttt gcatagcaag acattattgc ccttcagcct ggcagaaaaa cataaactca 600 ggtgtatatt ttataataaa cattgnattg aatgctaaga atgatcactg ttgaacatct 660 cctgaatggt ttgccttctt gtaaatcata ccaatggtta gacaattgaa attccagctc 720 tttct 725 276 744 DNA Homo Sapien misc_feature (1)...(744) n = A,T,C or G 276 nnnnntgann gtatacgact cactataggg cgaattgggc cctctagatg catgctcgag 60 cggccgccag tgtgatggat atctgcagaa ttcgccctta gcgtggtcgc ggccgaggta 120 cttctgctgt ggtaactcaa gtaaccctcc gtttaaacca ggacagacct atgctgacaa 180 ccatttttat cactcttagt ggtattttct ttctttgaac atgaatgcat atttctgctc 240 tttaatggcc tttggtattt aagattacat tcagctagtc tccttattgc atgttgtttt 300 attccagtcc caccagcact cagaacaaca gcaagtgtgt gtaacagcgg gcacaggcgc 360 tccagacgga aggacctcac tgacgcagtt agctcaggta gagcttattt ctgtgttcaa 420 ttttcttgtc atgagaagca gtgaccccta agaatttgta tccctttgtt cacttctttg 480 ttttaggaga gaaacttcta aagcattact ctaaaaggtg atagagacag agacgggcca 540 ttttcatcta ccccttgcag agttaagttt tattacagta agttgtgagg tgagacatga 600 tggctgcagg cacatagtca agatctaccc ttctaaggaa ataaaacggg gaaaagtggt 660 tgaatgtcca atatagaaaa tttaatcacc actttcccaa aaaagaataa atggaggact 720 ncattggaat tatggaaatg aaan 744 277 724 DNA Homo Sapien misc_feature (1)...(724) n = A,T,C or G 277 gnnnnttncg antgggccct ctagatgcat gctcgagcgg ccgccagtgt gatggatatc 60 tgcagaattc gcccttagcg tggtcgcggc cgaggtactt ctgctgtggt aactcaagta 120 accctccgtt taaaccagga cagacctatg ctgacaacca tttttatcac tcttagtggt 180 attttctttc tttgaacatg aatgcatatt tctgctcttt aatggccttt ggtatttaag 240 attacattca gctagtctcc ttattgcatg ttgttttatt ccagtcccac cagcactcag 300 aacaacagca agtgtgtgta acagcgggca caggcgctcc agacggaagg acctcactga 360 cgcagttagc tcaggtagag cttatttctg tgttcaattt tcttgtcatg agaagcagtg 420 acccctaaga atttgtatcc ctttgttcac ttctttgttt taggagagaa acttctaaag 480 cattactcta aaaggtgata gagacagaga cgggccattt tcatctaccc cttgcagagt 540 taagttttat tacagtaagt tgtgaggtga gacatgatgg ctgcaggcac atagtcaaga 600 tctacccttc taaggaaata aaacggggaa aagtggttga atgtccaata tagaaaattt 660 aatcaccact ttccaaaaaa gaataaatgg aggactncat tgtaattatg gaaatgaaat 720 ttgg 724 278 748 DNA Homo Sapien misc_feature (1)...(748) n = A,T,C or G 278 gnnnntgaaa gtatacgact cactataggg cgaattgggc cctctagatg catgctcgag 60 cggcccgcca gtgtgatgga tatctgcaga attcgccctt tcgagcggcc gcccgggcag 120 gtacagctgc ccaagggcgt tcgtaacggg aatgccgaag cgtgtgaaaa agggagcggt 180 ggcggaagac ggggatgagc tcaggacaga gccagaggcc aagaagagta agacggccgc 240 aaagaaaaat gacaaagagg cagcaggaga gggcccagcc ctgtatgagg accccccaga 300 tcagaaaacc tcacccagtg gcaaacctgc cacactcaag atctgctctt ggaatgtgga 360 tgggcttcga gcctggatta agaagaaagg attagattgg gtaaaggaag aagccccaga 420 tatactgtgc cttcaagaga ccaaatgttc agagaacaaa ctaccagctg aacttcagga 480 gctgcctgga ctctctcatc aatactggtc agctccttcg gacaaggaag ggtactagca 540 actaaccatg gttaaaaggt cttagtcaga attacaaaaa caaaacattt agagtaatac 600 ttatgaatac aagcataatt ggttcctcgc cttctacaaa taaccatctt gaaaatgata 660 aaagcaggtt tcaactgtgg tcttctctca ttgagaaggt gcagatacac atgggtgatc 720 tactgattta ccttcttgaa agtnctcg 748 279 727 DNA Homo Sapien misc_feature (1)...(727) n = A,T,C or G 279 gnnnnttcga ntgggccctc tngngcatgc tcgagcggca cgccagtgtg atggatatct 60 gcagaattcg ccctttcgag cggccgcccg ggcaggtaca gctgcccaag ggcgttcgta 120 acgggaatgc cgaagcgtgt gaaaaaggga gcggtggcgg aagacgggga tgagctcagg 180 acagagccag aggccaagaa gagtaagacg gccgcaaaga aaaatgacaa agaggcagca 240 ggagagggcc cagccctgta tgaggacccc ccagatcaga aaacctcacc cagtggcaaa 300 cctgccacac tcaagatctg ctcttggaat gtggatgggc ttcgagcctg gattaagaag 360 aaaggattag attgggtaaa ggaagaagcc ccagatatac tgtgccttca agagaccaaa 420 tgttcagaga acaaactacc agctgaactt caggagctgc ctggactctc tcatcaatac 480 tggtcagctc cttcggacaa ggaagggtac tagcaactaa ccatggttaa aaggtcttag 540 tcagaattac aaaaacaaaa catttagagt aatacttatg aatcaagcat aattggttcc 600 tcgccttcta caaataccat ctttgaaaat gatnaaaagc aggtttcaac tgtggttctt 660 ctctcanttg aaaaggtcag atcccatggg tgatctactg atttaccttc tgaaaagtac 720 ttggccg 727 280 751 DNA Homo Sapien misc_feature (1)...(751) n = A,T,C or G 280 gnnnntgann gtatacgact cactataggg cgaattgggc cctctagatg catgctcgag 60 cggccgccag tgtgatggat atctgcagaa ttcgccctta gcgtggtcgc ggccgaggta 120 ctcatgtatt tttttttttt tccagatctc tttccccaag ttgctattgt aagagtattc 180 tgctgcgtgt ggatgcagtt atacacatta aagcagatct ggagtctgaa gtagctataa 240 agcagctata aaacagaaat acatgcatag ctgcagaaac catgataggt agaggacttt 300 tcttttggtt ttgttttgtt ttgttttgtt ttgtttttgg ttttacagag aagagatttt 360 tattacaaag aaaaaaattc cagtgaattg tgcagaaatg ctggttttta caccatccta 420 aagaaaaact ttacaagggt gttttggagt agaaaaaagg ttataaagtt ggaatcttaa 480 attgtaaaat taaccattga gtgtcaaagt tctaaaagca gaactcattt tgtgcaatga 540 acataaggaa agactactgn ataggttttt tttttctcct tttaaatgaa gaaaagcttt 600 gcttaagggt tgcatacttt tattggagta aatctgaatg atcctactcc tttggagtaa 660 aactagtgct taccagtttc caattggatt taacttctgg ggtggaattt ggaaaaaaaa 720 agaannnngg aaaaagaaaa cctaanttaa n 751 281 727 DNA Homo Sapien misc_feature (1)...(727) n = A,T,C or G 281 gnnnttcgan tgggccctct agatgcatgc tcgagcggcc gccagtgtga tggatatctg 60 cagaattcgc ccttagcgtg gtcgcggccg aggtactcat gtattttttt ttttttccag 120 atctctttcc ccaagttgct attgtaagag tattctgctg cgtgtggatg cagttataca 180 cattaaagca gatctggagt ctgaagtagc tataaagcag ctataaaaca gaaatacatg 240 catagctgca gaaaccatga taggtagagg acttttcttt tggttttgtt ttgttttgtt 300 ttgttttgtt tttggtttta cagagaagag atttttatta caaagaaaaa aattccagtg 360 aattgtgcag aaatgctggt ttttacacca tcctaaagaa aaactttaca agggtgtttt 420 ggagtagaaa aaaggttata aagttggaat cttaaattgt aaaattaacc attgagtgtc 480 aaagttctaa aagcagaact cattttgtgc aatgaacata aggaaagact actgnatagg 540 tttttttttt ctccttttaa atgaagaaaa gctttgctta agggttgcat acttttattg 600 gagtaaatct gaatgatcct actcctttgg agtaaaacta gngcttccag tttccaattg 660 gatttaactt ctggntggaa tttgnaaaaa aaagaanaaa aggaaaanga aaccctaant 720 naaatag 727 282 749 DNA Homo Sapien misc_feature (1)...(749) n = A,T,C or G 282 tnnaaagnaa gctctttact cactatnngg gcgaattggg ccctctagat gcatgctcga 60 gcggccgcca gtgtgatgga tatctgcaga attctncctt cgagcggccg cccgggcagg 120 tacttttttt tttttttttt tttttttttt tttttnaaac tactaggatt tactgtagga 180 taaaagctnt acatggccct gcntacaaac tttctgcata cttctgcaaa tttttatgcn 240 ttactnaatc cattaaaaat caccttggaa naaactgcaa acncantana aactaaatga 300 natagtcaca gagaacanca aaaatagtaa ttnaagttcc catacaacat caagtgtgtn 360 cagtctattt tnggttcttc gggttctctt taaaattgaa ttgagtttgn atatgcatat 420 gtatgtagga gtggaggatg gaattaatta tcccaaacat cctacantca ctcctctaat 480 atttctttng ttaacatgca aatctgttct cttcattacg gngatactgc atttacatta 540 caacacantt agagatcatt aactttctcc tttataatca gccattttca caggcctttg 600 atatacaagc acctataata tattcttact catctcacac tttcatttac caaagtgtca 660 aaacaacatt tttacatcat tgatatttgg ttnantttct gcaanctggc tgttanaaaa 720 tgattacttc tnttaaatta ccttttanc 749 283 730 DNA Homo Sapien misc_feature (1)...(730) n = A,T,C or G 283 gtctntgaan cnggncctct ngatgcatgc tcgagcggcc gccagtgtga tggatatctg 60 cagaattcgc ccttcgagcg gccgcccggg caggtacttt tttttttttt tttttttttt 120 tttttttttc aaactactag gatttactgt aggataaaag ctntacatgg ccctgcatac 180 aaactttntg catacttntg caaattttta tgcattactc aatccattaa aaatcacctt 240 ggaanaaact gcaaacncaa tagaaactaa atganatagt cacagagaac aacaaaaata 300 gtaatttaag ttcccataca acatcaagtg tgttcagtct atttttggtt cttcgggttc 360 tctttaaaat tgaattgagt ttgtatatgc atatgtatgt aggantggag gatggaatta 420 attatcccaa acatcctaca ctcactcctc taatatttct tttgttaaca tgcaaatctg 480 ttctcttcat tacggngata ctgcatttac attacaacac aattagagat cattaacttt 540 ctcctttata atcagccatt ttcacaggcc tttgatatac aagcacctat aatatattct 600 tactcatctt acactttcat ttaccaaagt gtcaaaaaca acatttttac atcattggat 660 atttggttta gtttctgcaa nctggctttt anaaaaatga ttacttctct taaattacct 720 tttaccctca 730 284 739 DNA Homo Sapien misc_feature (1)...(739) n = A,T,C or G 284 gnnntnaaag tatacgactc actatagggc gaattgggcc ctctagatgc atgctcgagc 60 ggccgccagt gtgatggata tctgcagaat tcgcccttag cgtggtcgcg gccgaggtac 120 aacataaagc aacagagagg tcttcatgtt tgggaagtgg ctgggcagga tgccaaaccc 180 caaatgactt attgagcaat ttctaaacca aacagagagg taggaaaaga ggatgggggt 240 caggggtgga ggctgtggaa aggggagagc gagggctgaa gagaatggca gccatacagg 300 tgttttgttt ttatttccac atctgaggac tgagagtctg atttgctgcc tgtccatttc 360 cgccactcat tgactgtcca tagttcatca tgccattggc tccatagaag ttcatcccag 420 ccatctgctg ggtcatctga gtaaggttcc attgcagctg ctgagctggc tggaccccat 480 acacagtctg gggcatagct gccatgcctg ccatgtagcc agcctgctgg gtggtcatca 540 ttccattcgg cacacccatc attgatgcct gcatgccacc catatagcct gcaggcatgg 600 ccatgggggc aaccatccca gaactnctgc tgagcaacca tgcctactgg tggaagcatc 660 atgcttccca ttatgctgtt angangtgta ccccngggaa actggggtag ctgtgggata 720 tccatctgan ccggaccat 739 285 721 DNA Homo Sapien misc_feature (1)...(721) n = A,T,C or G 285 gnnnttcgan tgggccctct ngatgcatgc tcgagcggcc gccagtgtga tggatatctg 60 cagaattcgc ccttagcgtg gtcgcggcac gaggtacaac ataaagcaac agagaggtct 120 tcatgtttgg gaagtggctg ggcaggatgc caaaccccaa atgacttatt gagcaatttc 180 taaaccaaac agagaggtag gaaaagagga tgggggtcag gggtggaggc tgtggaaagg 240 ggagagcgag ggctgaagag aatggcagcc atacaggtgt tttgttttta tttccacatc 300 tgaggactga gagtctgatt tgctgcctgt ccatttccgc cactcattga ctgtccatag 360 ttcatcatgc cattggctcc atagaagttc atcccagcca tctgctgggt catctgagta 420 aggttccatt gcagctgctg agctggctgg accccataca cagtctgggg catagctgcc 480 atgcctgcca tgtagccagc ctgctgggtg gtcatcattc cattcggcac acccatcatt 540 gatgcctgca tgccacccat atagcctgca ngcatggcca tgggggcaac catcccagaa 600 ctcctggctg agcaaccatg cctactggtg gangcatcat gcttcccatt atgctgttag 660 gangtgtacc ccggggaanc tggggtagct gtgggatatc catttaaccg gagccatgaa 720 c 721 286 757 DNA Homo Sapien misc_feature (1)...(757) n = A,T,C or G 286 gnnnnttaaa gnntacgact cactataggg cgaattgggc cctctagatg catgctcgag 60 cggcccgcca gtgtgatgga tatctgcaga attcgccctt tcgagcggcc gcccgggcag 120 gacgcggggg ttgcaccatg gcgtccatgg ggaccctcgc cttcgatgaa tatgggcgcc 180 ctttcctcat catcaaggat caggaccgca agtcccgtct tatgggactt gaggccctca 240 agtctcatat aatggcagca aaggctgtag caaatacaat gagaacatca cttggaccaa 300 atgggcttga taagatgatg gtggataagg atggggatgt gactgtaact aatgatgggg 360 ccaccatctt aagcatgatg gatgttgatc atcagattgc caagctgatg gtggaactgt 420 ccaagtctca ggatgatgaa attggagatg gaaccacagg agtggttgtc ctggctggtg 480 ccttgttaga agaagcggag caattgctag accgaggcat tcacccaatc agaatagccc 540 gatggctatg agcaggctgc tcgcgttgct attgaacacc tggacaagat cagcgatagc 600 gtccttgttg acataaagga caccgaaccc ctgattcaga cagcaaaaaa ccacgctggg 660 cttncaaaag tggtcaacag ttgtcaccga cagatggctt gaaaattgct gtgaaatgcc 720 cgtccttact gtaaccagat atngaaccgg aaaagac 757 287 726 DNA Homo Sapien misc_feature (1)...(726) n = A,T,C or G 287 gnnnnactga tttctggctc gaagttgnat ntgcggncgc cagtgtgatg gatatctgca 60 gaattcgccc tttcgagcgg ccgcccgggc aggacgcggg ggttgcacca tggcgtccat 120 ggggaccctc gccttcgatg aatatgggcg ccctttcctc atcatcaagg atcaggaccg 180 caagtcccgt cttatgggac ttgaggccct caagtctcat ataatggcag caaaggctgt 240 agcaaataca atgagaacat cacttggacc aaatgggctt gataagatga tggtggataa 300 ggatggggat gtgactgtaa ctaatgatgg ggccaccatc ttaagcatga tggatgttga 360 tcatcagatt gccaagctga tggtggaact gtccaagtct caggatgatg aaattggaga 420 tggaaccaca ggagtggttg tcctggctgg tgccttgtta gaagaagcgg agcaattgct 480 agaccgaggc attcacccaa tcagaatagc ccgatggcta tgagcaggct gctcgcgttg 540 ctattgaaca cctggacaag atcagcgata gcgtccttgn tgacataaag gacaccgaac 600 ccctgattca gacagcaaaa accacgctgg gctccaaaag tggtcaacag ttgtcaccga 660 cagatggctg aaaatgctgt gaatgccgtc ctnctgtanc agatatngaa ccggaaaaga 720 ccttga 726 288 743 DNA Homo Sapien misc_feature (1)...(743) n = A,T,C or G 288 gnnntganng tatacgactc actatagggc gaattgggcc ctctagatgc atgctcgagc 60 ggccgccagt gtgatggata tctgcagaat tcgcccttcg gccgcccggg caggtacctt 120 ttacctaaaa ttctagccac tttaatttgg agagtttcca gagcaaaggg cacagatccc 180 aggcataaca acgctttgcg tatacagcaa ccaatatctt gtcaacccaa gaaagttcct 240 ccattgatac ctagtagaaa tagcccagtt tttaaagtcc tcaaaactgt aacaaattac 300 ttgtttttaa aatttaactt aaattaatac aatcagattt ttgtgttatt tgggtattag 360 agtatgttaa agcacatata tcccagagac atagagtttc cgtttcaaaa agtcatgcat 420 tcatgtgtgc taatgacaat cctatcctga cccgctatgt gacttgtatc tctaaaccat 480 aggctttcct gaattttatc tgttaattta accctgattt ctcagcagca gcttctcttt 540 gtaaatagac ttgcctcttc tgtgtctgac ctctgctcct cataatcaga ttaactcaga 600 taaagctgct tcagggaaga ggtcaaaacc gttgccaaaa atagtagttg ccctacttca 660 gtctattttc aacagagtag cccaggagat ctgtcacacc aaagtccaat cagccctact 720 ggtagcactc tgntcacaag ccn 743 289 726 DNA Homo Sapien misc_feature (1)...(726) n = A,T,C or G 289 gnnnnnactc gcagtccgtc tagatgcatg ctcgagcggc cgccagtgtg atggatatct 60 gcagaattcg cccttcggcc gcccgggcag gtacctttta cctaaaattc tagccacttt 120 aatttggaga gtttccagag caaagggcac agatcccagg cataacaacg ctttgcgtat 180 acagcaacca atatcttgtc aacccaagaa agttcctcca ttgataccta gtagaaatag 240 cccagttttt aaagtcctca aaactgtaac aaattacttg tttttaaaat ttaacttaaa 300 ttaatacaat cagatttttg tgttatttgg gtattagagt atgttaaagc acatatatcc 360 cagagacata gagtttccgt ttcaaaaagt catgcattca tgtgtgctaa tgacaatcct 420 atcctgaccc gctatgtgac ttgtatctct aaaccatagg ctttcctgaa ttttatctgt 480 taatttaacc ctgatttctc agcagcagct tctctttgta aatagacttg cctcttctgt 540 gtctgacctc tgctcctcat aatcagatta actcagataa agctgcttca gggaagaggt 600 caaaaccgtt gccaaaaata gtagttgccc tacttcagtc tattttcaac agagtagcca 660 ggagatctgt tcacaccaaa gtccaatcag ccctactggt agcactctgc tcacaagcct 720 ncagtg 726 290 740 DNA Homo Sapien misc_feature (1)...(740) n = A,T,C or G 290 gnnnngaaag tatacgactc actatagggc gaattgggcc ctctagatgc atgctcgagc 60 ggccgccagt gtgatggata tctgcagaat tcgcccttag cgtggtcgcg gccgaggtac 120 ccagatgtct ttctcggtca ccttcccgag accatttaag acctccctag ctgctcgttc 180 tccagcctca actgcccctt ccatgtagcc gctccacttt gtggcagtct ctgtgcccgc 240 aaagaaaatc ctgcccacgg gttgacgaat cacccttcca tattgagtca tgatcccagg 300 agggaagtag gccgtgtagc agcccccaga gtacctgccc gggcggccgc tcgaaagggc 360 gaattccagc acactggcgg ccgttactag tggatccgag ctcggtacca agcttggcgt 420 aatcatggtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca 480 tacgagccgg aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat 540 taattgcgtt gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt 600 aatgaatcgg ccaacgcgcc ggggagaggc ggnttgcgta ttgggcgctc ttncgctttc 660 tngctcactg actcgctgcg ctcggtcgtt cggctgcggc nagcggtatc agctcattaa 720 angcggtaat acggtatccn 740 291 724 DNA Homo Sapien misc_feature (1)...(724) n = A,T,C or G 291 gnnnnnncna ntgggccctc tngngcatgc tcgagcggcc gccagtgtga tggatatctg 60 cagaattcgc ccttagcgtg gtcgcggccg aggtacccag atgtctttct cggtcacctt 120 cccgagacca tttaagacct ccctagctgc tcgttctcca gcctcaactg ccccttccat 180 gtagccgctc cactttgtgg cagtctctgt gcccgcaaag aaaatcctgc ccacgggttg 240 acgaatcacc cttccatatt gagtcatgat cccaggaggg aagtaggccg tgtagcagcc 300 cccagagtac ctgcccgggc ggccgctcga aagggcgaat tccagcacac tggcggccgt 360 tactagtgga tccgagctcg gtaccaagct tggcgtaatc atggtcatag ctgtttcctg 420 tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta 480 aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg 540 ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga 600 gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgcttng 660 nccgtccggt tgcggcagcg gtataactna ctcaaaggcg gtaataccgg tatncacaga 720 atca 724 292 740 DNA Homo Sapien misc_feature (1)...(740) n = A,T,C or G 292 gnnnngnang tatacgactc actatagggc gaattgggcc ctctagatgc atgctcgagc 60 ggcccgccag tgtgatggat atctgcagaa ttcgccctta gcgtggtcgc ggccgaggta 120 cagaaagaat caaagaacat atatatatat taagtttcat tccaacctac aaagagcctg 180 cacttaaaag tcttaaaggt ttcctgaatc atggaatctc aacttacctg ccaattaatc 240 cagttctctc tttttaaatg cagactccaa ccttaaacag aaggcatatt ctagctgact 300 tctaagtgtg tccaaagcat acctcagaga gccaagtggt ctgtgttcaa tacctattct 360 ttctatagaa tctcaaaagt ggcagtatga tgaaaagaaa agctactttt tctcctaaaa 420 atacccccct tcatcatcag tgtgttgtca tttttgcatc acaaagaata gacattctaa 480 atgttccctt ccacacagaa agacataaga gagaatgtga gtatgagtga gagtgtgtag 540 gtaagttgag ggatagtttg ctatccaaaa tgaatcattt tgaagatgac tttgtaaaga 600 agtaatatag ttaaaaatct caagacatga gattgangan ggcagggaaa taaaggacct 660 angaatggaa aagagttaca gcccatgtga atacatacac aaacctacca ggttatttct 720 gngaattctc acacaggttg 740 293 723 DNA Homo Sapien misc_feature (1)...(723) n = A,T,C or G 293 gnnnnnnncn annggccctc tagatgcatg ctcgagcggc cgccagtgtg atggatatct 60 gcagaattcg cccttagcgt ggtcgcggcc gaggtacaga aagaatcaaa gaacatatat 120 atatattaag tttcattcca acctacaaag agcctgcact taaaagtctt aaaggtttcc 180 tgaatcatgg aatctcaact tacctgccaa ttaatccagt tctctctttt taaatgcaga 240 ctccaacctt aaacagaagg catattctag ctgacttcta agtgtgtcca aagcatacct 300 cagagagcca agtggtctgt gttcaatacc tattctttct atagaatctc aaaagtggca 360 gtatgatgaa aagaaaagct actttttctc ctaaaaatac cccccttcat catcagtgtg 420 ttgtcatttt tgcatcacaa agaatagaca ttctaaatgt tcccttccac acagaaagac 480 ataagagaga atgtgagtat gagtgagagt gtgtaggtaa gttgagggat agtttgctat 540 ccaaaatgaa tcattttgaa gatgactttg taaagaagta atatagttaa aaatctcaag 600 agcatgagat tganganggc agggaaataa angcctagga atggaaaaga gttaacagcc 660 catgtgaata catagcacaa acctaccagg ttatttctgg gaatctnacc agtttgctgg 720 aaa 723 294 736 DNA Homo Sapien misc_feature (1)...(736) n = A,T,C or G 294 gnnnnnnnna gaccgactca ctatagggcg aattgggccc tctagatgca tgctcgagcg 60 gccgccagtg tgatggatat ctgcagaatt cgccctttcg agcggccgcc cgggcaggta 120 cctgggatta caggcaccca ccaccacgcc tggctaattt ttttttgtat ctttagtagg 180 gttttgccat gttggccagg ctggtcttta actcctacct cgtgatccac ccgcctcggc 240 cccccaaagt gctaggacca caggcgtgag ccaccacgcc cagccccctg tctctttttt 300 taaaacacaa tttaaaagca gaaagaaaaa atctgtgctg tttagactca gattcttaat 360 tagctagtat ttcttaattc aatcaataaa ttattaagac cttttcactg ctcccttttt 420 aaagtcttct ttggagtgat ttaagtgctt cttattacca agctctcaaa gagaagataa 480 aattaaaatc tgatgggtaa ccatttaaat aagacaactg gggtaaccca tttctccagg 540 acccctctct gcaacagaga gctattctct ttctttggcc tagtaaacct ctgctcttaa 600 cctttaaaaa aaaaaaaaaa gtacctcggc cgcgaccacg ctaanggcga attccagcac 660 actggcggcc gttactagtg gatccgaact cggtccaact tggcgtaatc atggcatagt 720 ggttcctgng tgaaan 736 295 725 DNA Homo Sapien misc_feature (1)...(725) n = A,T,C or G 295 gnnnnnnnnn anngngccct ctagatgcat gctcgagcgg ccgccagtgt gatggatatc 60 tgcagaattc gccctttcga gcggccgccc gggcaggtac ctgggattac aggcacccac 120 caccacgcct ggctaatttt tttttgtatc tttagtaggg ttttgccatg ttggccaggc 180 tggtctttaa ctcctacctc gtgatccacc cgcctcggcc ccccaaagtg ctaggaccac 240 aggcgtgagc caccacgccc agccccctgt ctcttttttt aaaacacaat ttaaaagcag 300 aaagaaaaaa tctgtgctgt ttagactcag attcttaatt agctagtatt tcttaattca 360 atcaataaat tattaagacc ttttcactgc tcccttttta aagtcttctt tggagtgatt 420 taagtgcttc ttattaccaa gctctcaaag agaagataaa attaaaatct gatgggtaac 480 catttaaata agacaactgg ggtaacccat ttctccagga cccctctctg caacagagag 540 ctattctctt tctttggcct agtaaacctc tgctcttaac ctttaaaaaa aaaaaaaaag 600 tacctcggcc gcgaccacgc taagggcgaa ttccagcaca ctggcggccg ttactagtgg 660 atccgaactc ggtaccaagc ttgcgtaatc atggcatagc tggttcctgt gtgaaatggt 720 atccg 725 296 742 DNA Homo Sapien misc_feature (1)...(742) n = A,T,C or G 296 gnnnnnnnnn nnacaaanct gggtagggcg aattgggccc tctagatgca tgctcgagcg 60 gccgccagtg tgatggatat ctgcagaatt cgccctttcg agcggccgcc cgggcaggta 120 ccatgctgac ttcttggtat cttttaaggc ctaattttcc cttccttgag attactgtag 180 tgtgttccag ctaatttcta tttggaaacg agttggaaca gctgaaaact aggtattatt 240 gaaggcaaag cagcctcacg tcagtttttt atcagctcat ttgggaagtt tttttttttt 300 ttttttttta attaattaga aagtaggctg ggcacggtgg ctcatgccta taatcccagc 360 acttggggag gccgaggatc tcctctctgg tggatcactt gagggcagga gttaagagac 420 catcctggcc aacatgatga aaccctgtct ctactaaaaa tacaaaaagt agctgggcgt 480 ggtggcatac tcttacaatc ccagctactt gggaggctga ggcaggagaa tcacttgaac 540 ctaggaagca gaggttgcag tgggccaaga tcacaccact atactctagc ctgggcgaca 600 gaagtgggga aaaaagtagg acccctgtcc tatattcang gttttctcac atatatgaac 660 ccatctaaat tctacgttgg taaaaggaac ctaaggttaa ttagnctata cttatttaag 720 aaccattntg gggnggagat gg 742 297 728 DNA Homo Sapien misc_feature (1)...(728) n = A,T,C or G 297 tnnnntttga anncnacnct ctagngcatg ctcgagcggc cgccagtgtg atggatatct 60 gcagaattcg ccctttcgag cggccgcccg ggcaggtacc atgctgactt cttggtatct 120 tttaaggcct aattttccct tccttgagat tactgtagtg tgttccagct aatttctatt 180 tggaaacgag ttggaacagc tgaaaactag gtattattga aggcaaagca gcctcacgtc 240 agttttttat cagctcattt gggaagtttt tttttttttt tttttttaat taattagaaa 300 gtaggctggg cacggtggct catgcctata atcccagcac ttggggaggc cgaggatctc 360 ctctctggtg gatcacttga gggcaggagt taagagacca tcctggccaa catgatgaaa 420 ccctgtctct actaaaaata caaaaagtag ctgggcgtgg tggcatactc ttacaatccc 480 agctacttgg gaggctgagg caggagaatc acttgaacct aggaagcaga ggttgcagtg 540 ggccaagatc acaccactat actctagcct gggcgacaga agtggggaaa aaagtaggac 600 ccctgtccta tattcangtt tttctcacat atatgaaccc atctaaattc tacgttggta 660 aaggtanctt aagttaatta gnctatactt atttaaganc aatatggggt gaaaatggat 720 tttttttn 728 298 745 DNA Homo Sapien misc_feature (1)...(745) n = A,T,C or G 298 gnnnnnttna nnnnatacga ctcactatat agggcgaatt gggccctcta gatgcatgct 60 cgagcggccg ccagtgtgat ggatatctgc agaattcgcc cttagcgtgg tcgcggccga 120 ggtacccacg ttttgctcca cactccttga ccgcaggggc tcggacacaa acccctgtca 180 ccaggagagt cagtcagcac tacttgggag ggctaaaggg aaatttggaa ataaaattcc 240 aaagtttgga gtaaaaaaat tcaagtgttg attttatatt ctttcccttt ctgacacagc 300 ctaaagcgta gggggaacat gtgtttatct gtgggagata aacaagatgg agtcccaaag 360 actttaacaa aatatttttt taaaaatcca ctagaataga aaatacatta tttagatata 420 ctttatgctg agagtgagta tatatgcttg tcctatttaa acttgtgaga aaaagtggta 480 tcccttgata catttagaaa tatgggggct atcttgtttc attgtggggg tggggcagaa 540 ggagaataaa tgcaggatga ccctgttgaa ggaatcttag catggccaac aggggacgtt 600 tccagtcgat taccaggaaa tgcaagcctt ggggtttcta ctggtggtgg ggctgtcatg 660 aactttaaaa tccaaagcct agacaaggaa aagtgttaga ccaattgaaa agcaatccac 720 cctttttttt tttttttttt ggctt 745 299 733 DNA Homo Sapien misc_feature (1)...(733) n = A,T,C or G 299 gnnnnnnnnn nnnnnnncct ctagatgctg ctcgaacggc cgccagtgtg atggatatct 60 gcagaattcg cccttagcgt ggtcgcggcc gaggtaccca cgttttgctc cacactcctt 120 gaccgcaggg gctcggacac aaacccctgt caccaggaga gtcagtcagc actacttggg 180 agggctaaag ggaaatttgg aaataaaatt ccaaagtttg gagtaaaaaa attcaagtgt 240 tgattttata ttctttccct ttctgacaca gcctaaagcg tagggggaac atgtgtttat 300 ctgtgggaga taaacaagat ggagtcccaa agactttaac aaaatatttt tttaaaaatc 360 cactagaata gaaaatacat tatttagata tactttatgc tgagagtgag tatatatgct 420 tgtcctattt aaacttgtga gaaaaagtgg tatcccttga tacatttaga aatatggggg 480 ctatcttgtt tcattgtggg ggtggggcag aaggagaata aatgccagga tgaccctgtt 540 gaaggaatct tancatggcc aacaggggac gtttccagtc gattaccagg aaatgcaagc 600 cttggggttt ctactggtgg tggggctgtc atgaacnttt aaaatccaaa gcctagacca 660 aggaaaagtg ttaganccan tggaaaagcc attccagccc tttttttttn nnnntttttg 720 gcttttcacc aca 733 300 741 DNA Homo Sapien misc_feature (1)...(741) n = A,T,C or G 300 gnnnntgann gtatacgaac tcactatagg gcgaattggg ccctctagat gcatgctcga 60 gcggccgcca gtgtgatgga tatctgcaga attcgccctt tcgagcggcc gcccgggcag 120 gtacgtagtc taggccatat gtgttggaga ttgagactag tagggctagg cccaccgctg 180 cttcgcaggc ggcaaagact agtatggcaa taggcacaat attggctaag agggagtggg 240 tgttgagggt tatgagagta gctataatga acagcgatag tattattcct tctaggcaca 300 gtagggagga tatgaggtgt gagcgatata ctagtattcc tagaagtgag atggtaaatg 360 ctagtataat atttatgtaa atgaggggcc ccgcgtactc aagtgggtct ctgcctctca 420 gtggtggcct tggtcttcaa gtttcagcaa ttctgggaag ccaaggacac ctccatctcc 480 tcctccctga tctgcaactc atctaagagc agctttctca ctggaatgtc ttgtgtttaa 540 ggaacaagaa tccctgtttc cggtttgggt gcccaagtgc acctactgga tccaacccag 600 gattggagat actttgcaga acacaacatc atctggcaca tgaccagcca tggtgtttca 660 ctttcacaat ttcagcttnc ttcactgatt gcagcataat cgnggtcaac accttcaaga 720 ccaaggctga tgtgggccgc t 741 301 724 DNA Homo Sapien misc_feature (1)...(724) n = A,T,C or G 301 gnnnnntncn antgggccct ctngngcatn gctcgagcgg cacgccagtg tgatggatat 60 ctgcagaatt cgccctttcg agcggccgcc cgggcaggta cgtagtctag gccatatgtg 120 ttggagattg agactagtag ggctaggccc accgctgctt cgcaggcggc aaagactagt 180 atggcaatag gcacaatatt ggctaagagg gagtgggtgt tgagggttat gagagtagct 240 ataatgaaca gcgatagtat tattccttct aggcacagta gggaggatat gaggtgtgag 300 cgatatacta gtattcctag aagtgagatg gtaaatgcta gtataatatt tatgtaaatg 360 aggggccccg cgtactcaag tgggtctctg cctctcagtg gtggccttgg tcttcaagtt 420 tcagcaattc tgggaagcca aggacacctc catctcctcc tccctgatct gcaactcatc 480 taagagcagc tttctcactg gaatgtcttg tgtttaagga acaagaatcc ctgtttccgg 540 tttgggtgcc caagtgcacc tactggatcc aacccaggat tggagatact ttgcagaaca 600 caacatcatc tggcacatga ccagccatgg tgtttcactt tcacaatttc agcttncttc 660 actgattgca cataatcgtg gtcaacacct tcaagaccan ggctgatgtn ggccgntaca 720 ngga 724 302 745 DNA Homo Sapien misc_feature (1)...(745) n = A,T,C or G 302 gnnnntgaaa gtntanacga ctcactatag ggcgaattgg gccctctaga tgcatgctcg 60 agcggccgcc agtgtgatgg atatctgcag aattcgccct ttcgagcggc cgcccgggca 120 ggtactattc cggatataca agatcactgg gagatgttga tgatggagac acagtgacag 180 atttcatggc ccaagagcga gaaagaggca ttactattca atcagctgct gttacatttg 240 attggaaagg ttatagagtc aatctaattg atacaccagg tcatgtggac tttaccttgg 300 aggttgagcg gtgcctaaga gtgttggatg gtgcagtggc tgtatttgat gcctctgctg 360 gtgtagaggc ccagactctc acagtatgga ggcaagctga taaacacaat atacctcgaa 420 tctgtttttt aaacaagatg gacaaaactg gagcaagctt taagtatgca gttgaaagca 480 tcagagagaa gttaaaggca aagcctttgc ttttacagtt accaattggt gaagccaaaa 540 ctttcaaagg agtggtggat gtagtaatga aagaaaaact tctttggaat tgcaattcaa 600 atgatggaaa agactttgag agaaagcccc tcttggaaat gaatgatcct gaattgctga 660 aggaaacaac tgaagcaagg aatgccttaa ttgaacaagt tgcagaattt ggatgatgaa 720 ttgctgactt gggtttanaa naaat 745 303 724 DNA Homo Sapien misc_feature (1)...(724) n = A,T,C or G 303 gnnnttcgan tgggcccttc tagatgcatg ctcgagcggc cgccagtgtg atggatatct 60 gcagaattcg ccctttcgag cggccgcccg ggcaggtact attccggata tacaagatca 120 ctgggagatg ttgatgatgg agacacagtg acagatttca tggcccaaga gcgagaaaga 180 ggcattacta ttcaatcagc tgctgttaca tttgattgga aaggttatag agtcaatcta 240 attgatacac caggtcatgt ggactttacc ttggaggttg agcggtgcct aagagtgttg 300 gatggtgcag tggctgtatt tgatgcctct gctggtgtag aggcccagac tctcacagta 360 tggaggcaag ctgataaaca caatatacct cgaatctgtt ttttaaacaa gatggacaaa 420 actggagcaa gctttaagta tgcagttgaa agcatcagag agaagttaaa ggcaaagcct 480 ttgcttttac agttaccaat tggtgaagcc aaaactttca aaggagtggt ggatgtagta 540 atgaaagaaa aacttctttg gaattgcaat tcaaatgatg gaaaagactt tgagagaaag 600 cccctcttgg aaatgaatga tcctgaattg ctgaaggaaa caactgaagc aaggaatgcc 660 ttaattgaca agttgcagat ttggatgatg aatttgctga cttggtttta gaagaattan 720 tgag 724 304 741 DNA Homo Sapien misc_feature (1)...(741) n = A,T,C or G 304 gnnnnnngaa agtntacgac tcactatagg gcgaattggg ccctctagat gcatgctcga 60 gcggccgcca gtgtgatgga tatctgcaga attcgccctt agcgtggtcg cggccgaggt 120 actttataaa tggaattttc ttctacttgt atccatttcc cggggcttat ggacccattc 180 atactctcca tatttagaat caaaggttcc tttctgaaga gaccttaatt ttaaggtaaa 240 acgtggtcca agttcctgaa ttcccacttt cttttcactc ctgaatatgt atctgtgaaa 300 tctgaagaat atgtaatccc gttgattgtg gaatgtggca acctgccttc cgataaattg 360 aggattatga ggaaagagag atgcaaacat acgtccaatt gaatgaccca gccgtgttgt 420 aaaattattc agaattattt caggtatgtg ttctgtgggg tccttgcctc ttctcttaat 480 ttctttacga agacgaacac tgctcatttt aaaatgagca gttgggccat ttggcaagtg 540 actcaaaata agtccatttg gggttttacg atcttcatta ataacaatca ggtctgtgaa 600 atctcttgcg atgcactgtg gaataatttt tttcagaacc agcctcttct gtaataaaca 660 tgtgagtttg gtataactgt gganagctgt cacagagtcg taccagtata ccaaccatac 720 caactntgtt gtagagcaaa a 741 305 719 DNA Homo Sapien misc_feature (1)...(719) n = A,T,C or G 305 gnnnttncaa ntgggccctc tngatgcatg ctcgagcggc cgccagtgtg atggatatct 60 gcagaattcg cccttagcgt ggtcgcggcc gaggtacttt ataaatggaa ttttcttcta 120 cttgtatcca tttcccgggg cttatggacc cattcatact ctccatattt agaatcaaag 180 gttcctttct gaagagacct taattttaag gtaaaacgtg gtccaagttc ctgaattccc 240 actttctttt cactcctgaa tatgtatctg tgaaatctga agaatatgta atcccgttga 300 ttgtggaatg tggcaacctg ccttccgata aattgaggat tatgaggaaa gagagatgca 360 aacatacgtc caattgaatg acccagccgt gttgtaaaat tattcagaat tatttcaggt 420 atgtgttctg tggggtcctt gcctcttctc ttaatttctt tacgaagacg aacactgctc 480 attttaaaat gagcagttgg gccatttggc aagtgactca aaataagtcc atttggggtt 540 ttacgatctt cattaataac aatcaggtct gtgaaatctc ttgcgatgca ctgtggaata 600 attttttcag agccagtcct cttctgtaat aaacatgtga agtttggtat actgtggana 660 gctgtcacag agtcgacagt ataccaacca taccaactct gttgnagaac anaacccat 719 306 746 DNA Homo Sapien misc_feature (1)...(746) n = A,T,C or G 306 gnnnnntgaa agtatacgac tcactatagg gcgaattggg ccctctagat gcatgctcga 60 gcggccgcca gtgtgatgga tatctgcaga attcgccctt tcgagcggcc gcccgggcag 120 gtactccagc ccaggcgaca gagtgagact cagtctcaaa aaaaaaaaaa atttgggcaa 180 gttatagtcc atctcatagt gttgttagga ctaatttctt catgtgctta gaaaaatgcc 240 tggcagatag gaaatggtca atattattat tattgataag atgaccattt tggagtttag 300 aaaaccattt tcaatgccta tgaaataaca actccataag ccattccctt aaatccagta 360 gactgaattc tcacaagtcc tcatcactca tcatttctac atcctgctga tttacaaata 420 cttcttcata ccatggttta tgtctttgct taatatcaag gaggatggat tccatggtag 480 agccaaactc aatgatacta cgagtctcat tttggtaagt ataagcaaag ccagcagcat 540 gcatggccac caatgaacct tttgaatcaa acacagggga gcccggaagc cccaaagaaa 600 aattcagtgt cataggtaat cacatcangg ttgtgaacta ttttctggaa acttctttga 660 gtatacatat ggacatactc tggactttct gcttttttag actgaacacg ttcctgacat 720 ttctttgctc gctgaccctg anggat 746 307 725 DNA Homo Sapien misc_feature (1)...(725) n = A,T,C or G 307 gnnnnntncn antggccctc tagatgcatg ctcgagcggc cgccagtgtg atggatatct 60 gcagaattcg ccctttcgag cggccgcccg ggcaggtact ccagcccagg cgacagagtg 120 agactcagtc tcaaaaaaaa aaaaaatttg ggcaagttat agtccatctc atagtgttgt 180 taggactaat ttcttcatgt gcttagaaaa atgcctggca gataggaaat ggtcaatatt 240 attattattg ataagatgac cattttggag tttagaaaac cattttcaat gcctatgaaa 300 taacaactcc ataagccatt cccttaaatc cagtagactg aattctcaca agtcctcatc 360 actcatcatt tctacatcct gctgatttac aaatacttct tcataccatg gtttatgtct 420 ttgcttaata tcaaggagga tggattccat ggtagagcca aactcaatga tactacgagt 480 ctcattttgg taagtataag caaagccagc agcatgcatg gccaccaatg aaccttttga 540 atcaaacaca ggggagccgg aagccccaaa gaaaaattca gtgtcatagg taatcacatc 600 anggttgtga actattttct ggaaacttct ttgagtatac atatggacat actctggact 660 ttctgctttt ttagactgac acgttcctga catttctttg ctcgctgacc ctgagggatc 720 acang 725 308 744 DNA Homo Sapien misc_feature (1)...(744) n = A,T,C or G 308 gnnnntgaaa gtaatacgac tcactatagg gcgaattggg ccctctagat gcatgctcga 60 gcggccgcca gtgtgatgga tatctgcaga attcgccctt tcgagcggcc gcccgggcag 120 gtacgcgggg tgacaagtag caacatggct tgggtcccct gtgcagcatc agcttatgct 180 gccacaagtc agtttgcacc ctaggtaccc aggagctagt atccttagat ctttctatcg 240 ctaacttaat tctcttcgtt atttatctga ccctctaact ccatgtctaa cttgcattaa 300 aaaaaaaaaa attctttaca gtcaacccaa gcttaacatg gactcaggtt ccccagcagc 360 cttaatttgt tttgttaaca tctgttcctt ctttttcagc tctcctagag tatttctgag 420 tgttgtgttc atctaatctt agtattcttt taattacaaa ttgacctcac agcttgaggt 480 ttcctgtgtc ttattctgtg gactacctgt gctcctttgc ttcccctccc ctcgcataat 540 aactatatta agaaattttt tttggccttg agttggctgg aaaaaaaata taaaatttaa 600 aaaaaaaaan nnnnnnnnaa aaaaaaaaag tacctnggcc gggaccacgc taanggcgaa 660 ttccagcaca ctggcggccg ttactaagtg gatccgaact cggtaccaac ttggcgtaat 720 catggcatag ctggttcctg ngga 744 309 746 DNA Homo Sapien misc_feature (1)...(746) n = A,T,C or G 309 gnnnntncga ntgggccctc tagatgcatg ctcgagcggc cgccagtgtg atggatatct 60 gcagaattcg ccctttcgag cggccgcccg ggcaggtacg cggggtgaca agtagcaaca 120 tggcttgggt cccctgtgca gcatcagctt atgctgccac aagtcagttt gcaccctagg 180 tacccaggag ctagtatcct tagatctttc tatcgctaac ttaattctct tcgttattta 240 tctgaccctc taactccatg tctaacttgc attaaaaaaa aaaaaattct ttacagtcaa 300 cccaagctta acatggactc aggttcccca gcagccttaa tttgttttgt taacatctgt 360 tccttctttt tcagctctcc tagagtattt ctgagtgttg tgttcatcta atcttagtat 420 tcttttaatt acaaattgac ctcacagctt gaggtttcct gtgtcttatt ctgtggacta 480 cctgtgctcc tttgcttccc ctcccctcgc ataataacta tattaagaaa ttttttttgg 540 ccttgagttg gctggaaaaa aaatataaaa tttaaaaaaa aaannnnnnn nnnnaaaaaa 600 aaaagtcctt ggccgggacc acnctaangg cgaaattcca gcacaactgg gcggnccgtt 660 actaagggga atcccnaact tnggnacccn aaacttgggc gtaaaacaat gggncaataa 720 gctggnnncc ctggnggtga aaaatt 746 310 751 DNA Homo Sapien misc_feature (1)...(751) n = A,T,C or G 310 gnnnntgana gtaatacgac tcactatagg gcgaattggg ccctctagat gcatgctcga 60 gcggccgcca gtgtgatgga tatctgcaga attcgccctt tcgagcggcc gcccgggcag 120 gtacttaatg cctttctcct cctggacatc agagagaaca cctgggtatt ctggcagaag 180 tttatatttc tccaaatcaa tttctggaaa aaacgtgtca ctttcaaagt cttgcatgat 240 ccttgtcaca aatagtttaa gatggcctgg gtgattcatg gcttccttat aaacagaact 300 gccaccaact atccagacca tgtctacttt atttgctaat tctggttgtt cagtaagttt 360 taaggcatca tctagacttc tggaaagaaa atgagctcct tgtggaggtt ccttgagttc 420 tctgctgaga actaaattaa ttctaccctt taaaggtcga ttcttctcag gaatggagaa 480 ccaggtcttc ttacccataa tcaccagatt ctgnttacct tctactgaag aagttgtggt 540 cattctctgg aaatatctga attcattcct gagcggtggc caaggcangt ncccgttctt 600 gccgatgccc atgttctggg acacagcgac gatgcagttt agcgaaccaa ccatgacagc 660 aaccgggang accttcgagc cccgttcgnt acaagccccc gcgtaccttn gggccgngaa 720 cacgcttaag ggcgaattnc aacacactgg c 751 311 724 DNA Homo Sapien misc_feature (1)...(724) n = A,T,C or G 311 gnnttncnan tgggccctct agatgcatgc tcgagcggcc gccagtgtga tggatatctg 60 cagaattcgc cctttcgagc ggccgcccgg gcaggtactt aatgcctttc tcctcctgga 120 catcagagag aacacctggg tattctggca gaagtttata tttctccaaa tcaatttctg 180 gaaaaaacgt gtcactttca aagtcttgca tgatccttgt cacaaatagt ttaagatggc 240 ctgggtgatt catggcttcc ttataaacag aactgccacc aactatccag accatgtcta 300 ctttatttgc taattctggt tgttcagtaa gttttaaggc atcatctaga cttctggaaa 360 gaaaatgagc tccttgtgga ggttccttga gttctctgct gagaactaaa ttaattctac 420 cctttaaagg tcgattcttc tcaggaatgg agaaccaggt cttcttaccc ataatcacca 480 gattctgttt accttctact gaagaggttg tggtcattct ctggaaatat ctgaattcat 540 tcctgagcgg tggccaaggc angtccccgt tcttgccgat gcccatgttc tgggacacag 600 cgacgatgca gtttancgaa ccacccatga cagcagcggg aggaccttcg agcccgctcg 660 ttacaagccc ccgcgtacct tnggccgcga acaccttang gcgaaattca acacactggc 720 ggcc 724 312 738 DNA Homo Sapien misc_feature (1)...(738) n = A,T,C or G 312 nnnntttgaa gnctacnact cactataggg cgaattgggc cctctagatg catgctcgag 60 cggccgccag tgtgatggat atctgcagaa ttcgcccttt gagcggccgc ccgggcaggt 120 acgcgggggg cagacatggc gacattgaca gtggtccagc cgctcaccct ggacagagat 180 gttgcaagag caattgaatt actggaaaaa ctacaggaat ctggagaagt acgttcacta 240 attatctaca aggacaaaat cagttgtatt tacaaaactc tacttcagtg tttgttttag 300 tttttttttt actgaaactt gtttttgtga atactctgtg cttagaatta aatatcactt 360 tcttatgaac aacataactt cttcagattg tgtatatgaa aacattagca agtcttgttt 420 tttctatgaa gcaaacacaa ttggtgacaa aggttgtcaa tcatttcttc aaaattataa 480 tgcagttcta atggtcagca tattttgata ttaaatttaa agatcacctc tctgcatttg 540 tttttaaatt atgctaatac accacacatt atgttggtat gttttggtct gtcctcggcc 600 gcgaccacgc ttanggcgaa ttccagcaca ctggcgggcc gttactagtg gatccgagct 660 cggtccaagc tggcgtaatc atggtcatag ctggttcctg tgtgaaatgg tatccgttac 720 aattcccaca catacgan 738 313 720 DNA Homo Sapien misc_feature (1)...(720) n = A,T,C or G 313 gnnttncaan tgggccctct agatgcatgc tcgagcggcc gccagtgtga tggatatctg 60 cagaattcgc cctttgagcg gccgcccggg caggtacgcg gggggcagac atggcgacat 120 tgacagtggt ccagccgctc accctggaca gagatgttgc aagagcaatt gaattactgg 180 aaaaactaca ggaatctgga gaagtacgtt cactaattat ctacaaggac aaaatcagtt 240 gtatttacaa aactctactt cagtgtttgt tttagttttt tttttactga aacttgtttt 300 tgtgaatact ctgtgcttag aattaaatat cactttctta tgaacaacat aacttcttca 360 gattgtgtat atgaaaacat tagcaagtct tgttttttct atgaagcaaa cacaattggt 420 gacaaaggtt gtcaatcatt tcttcaaaat tataatgcag ttctaatggt cagcatattt 480 tgatattaaa tttaaagatc acctctctgc atttgttttt aaattatgct aatacaccac 540 acattatgtt ggtatgtttt gntctgtacc tcggccgcga ccacgctaan ggcgaattca 600 ncacactggc ngncgttact agtggatccg agctcggacc aaacttggcg taatcatngn 660 catagctggt tcctgtgtga aaatggtatc cgttacaatt tcacacacat acgagccgga 720 314 740 DNA Homo Sapien misc_feature (1)...(740) n = A,T,C or G 314 gnnnnttnaa gnctacgact cactataggg cgaattgggc cctctagatg catgctcgag 60 cggccgccag tgtgatggat atctgcagaa ttcgccctta gcgtggtcgc ggccgaggta 120 cttttttttt tttttttttt ttagtgcttt ctactttatt aaacatcaaa gcccaaatag 180 atgttccctg tggaggagga cttaaggaca ctaggggagg agaaagggac acctgggaag 240 agaatcacac cacagagacc aatcttcaca aaaagggtcc aatattgatt tctagggagg 300 agcagggcat ggtcagctca aatttggtga taacgtcagg atgaaggacc ccaagcttcc 360 cgacgctttg acccctggca aagatctctg cacatcgccc ggggaagaaa gcaggccctt 420 ctgatgcttt gatcacatat ccccccttgt cttcaccagg aggcacatcg agcaactgca 480 taattctgtc cagcagccca tgaatgatct caaacccagg attcttgntg taataaacag 540 cactgagatg tctgtagttt tttgcaccta catctgnatt agaatctttt attacaatgt 600 cagagatttc aaacagtttc agtggaaggg gcatcttacg attgctgcta tggcttcagg 660 angccaggaa gaagggtagt gcgtgccacc tgaaattcac tggtttagga tacttatgtg 720 gactggcttt gttgcaaaan 740 315 722 DNA Homo Sapien misc_feature (1)...(722) n = A,T,C or G 315 gnnnnnnnnn nnnnnnntnn atgctgctcg agcggccgcc agtgtgatgg atatctgcag 60 aattcgccct tagcgtggtc gcggccgagg tacttttttt tttttttttt ttttagtgct 120 ttctacttta ttaaacatca aagcccaaat agatgttccc tgtggaggag gacttaagga 180 cactagggga ggagaaaggg acacctggga agagaatcac accacagaga ccaatcttca 240 caaaaagggt ccaatattga tttctaggga ggagcagggc atggtcagct caaatttggt 300 gataacgtca ggatgaagga ccccaagctt cccgacgctt tgacccctgg caaagatctc 360 tgcacatcgc ccggggaaga aagcaggccc ttctgatgct ttgatcacat atcccccctt 420 gtcttcacca ggaggcacat cgagcaactg cataattctg tccagcagcc catgaatgat 480 ctcaaaccca ggattcttgt tgtaataaac agcactgaga tgtctgtagt tttttgcacc 540 tacatctgna ttagaatctt ttattacaat gtcagagatt tcaaacagtt tcagtggaaa 600 ggggcatctt acgatttgct gctatggnct tcangaggnc angaaaaagg gtantgcntg 660 cccctgaaat tcanctggtt taggattacc tatgtggact ggctttgntg caaaaaaatn 720 cn 722 316 753 DNA Homo Sapien misc_feature (1)...(753) n = A,T,C or G 316 gnnnnnttna nagtnnnnac gactcactat aggggcgaac nctctncatg catgctcnan 60 cggncnncan ngtgatggat atntgctgan ttcgccctta ccntngcntn ggccgaggcg 120 cagntcccac gtntngctcc ncactncnnn accgcagggg cncngacncn gaccngngnn 180 ncnnngngag tnccncagca ctacttggga nggctanagg gaagnttgga aataaaattc 240 caaannttgg agtaaaagca atncangcgn ngattatata tgntnnccct ttctgacacn 300 ncctagagcg tagggggaac atgngtntat ctgtgggana tnaacaagat ggagtcccaa 360 agactttaac aaagntattt cttaannatc cnctacaatn nanaatncat tattcatatn 420 tactntatgc tgnnagtgag tatntatgct ngtcctattt aaacttgnga gaanaagtgg 480 tntcccttga tacattnaga aatatggggg ctatcttgnt ncattgtggg ggtggggcan 540 aagganaatn aatgcangat gaccctgttg aangaatctt aacatggcca acanggggac 600 ngtttacagt cgattaccag gaaangcaag ccttggggtt tctactgcng gtgggggctg 660 tcatgaactt naaaatccan agnctatacc aggaaaaagt gttangaccc aattgaaang 720 ctntccaccc tttcttttnn tttgttccng cnc 753 317 893 DNA Homo Sapien misc_feature (1)...(893) n = A,T,C or G 317 gtgnnntntn cnaaatggnc cntttnaatg cctncctcga gcgggccgcc agtgtgatgg 60 atntntaatt cgnccttagc gtggtcgcgg ccgnngtacn aangaaataa aantnacagt 120 ntcaaagaac caaantaagt cggacacaaa cccctgtcac cannagagtc ccatanacat 180 aannnggntg ntgtcaagna ggattnaaat taactttaac aacnttntat ataatgctac 240 attccccaat taataaagga nagttcacat atacanctaa ntgntaattg tggaaanaag 300 ggtgaaantn tgcatantta atannaaana atgctgaang cttttncata nnattnnctt 360 aaaaatncac ttncnatgca gcantangtn tacatgctta atntatcntg cnagtgattn 420 ntatgcttgt cctacatgac ntaccttgaa caactggnac tncccagatt catactgaaa 480 tatggggncg ntaantatnt tgggancggn annacntgaa tcctcaaagg atannnnntn 540 tccagntgga tgaaaccnat nattnaaang gatatnntna accatnggan cgaatgnncg 600 nngntctttt tcaatnntnc gngaagntnc cnnttnnata ncccgngggc cncattgngg 660 ggnntatntn ncaatcaann ccnngagntg tntnntcntt cntcnaccgc ataacctttt 720 gccataggga accttntttn aacccctttg gnttatnggg aaanaannnn nnttttaaat 780 tcnccaaaat ngggaaaaan aacccttntc actctaaaaa nttanccnta gacctanttn 840 tngngncata tttgntaaac nctatggncc ctcnagnggg gnnctgggnc nnc 893 318 744 DNA Homo Sapien misc_feature (1)...(744) n = A,T,C or G 318 gnnnngattg tatacgactc actatagggc gaattgggcc ctctagatgc atgctcgagc 60 ggccgccagt gtgatggata tctgcagaat tcgccctttc gagcggccgc ccgggcaggt 120 acctcattag taattgtttt gttgtttcat ttttttctaa tgtctcccct ctaccagctc 180 acctgagata acagaatgaa aatggaagga cagccagatt tctcctttgc tctctgctca 240 ttctctctga agtctaggtt acccattttg gggacccatt ataggcaata aacacagttc 300 ccaaagcatt tggacagttt cttgttgtgt tttagaatgg ttttcctttt tcttagcctt 360 ttcctgcaaa aggctcactc agtcccttgc ttgctcagtg gactgggctc cccagggcct 420 aggctgcctt cttttccatg tcccacccat gagccctcca ctggacagct cagtaagcct 480 ggcccttcat tctgcgctgt gttcttcctc tgtgaaaatc caatacctct tacctcctct 540 gcatgcaaag attctcaagg attgtcagac ttcaaacgta acagcagaac caccagaagg 600 tcctataaat gcagtagtga ccttctcaag ctgtcanggc tttaaatagg atttgggatt 660 taatgctatg tatttttaaa ggaaagaaat aagagttgct agttttaaaa atgcatgtct 720 tttaccaatt canaatctgg cccc 744 319 720 DNA Homo Sapien misc_feature (1)...(720) n = A,T,C or G 319 gngtttaaac cttcttanng ctgctcgagc ggccgccagt gtgatggata tctgcagaat 60 tcgccctttc gagcggccgc ccgggcaggt acctcattag taattgtttt gttgtttcat 120 ttttttctaa tgtctcccct ctaccagctc acctgagata acagaatgaa aatggaagga 180 cagccagatt tctcctttgc tctctgctca ttctctctga agtctaggtt acccattttg 240 gggacccatt ataggcaata aacacagttc ccaaagcatt tggacagttt cttgttgtgt 300 tttagaatgg ttttcctttt tcttagcctt ttcctgcaaa aggctcactc agtcccttgc 360 ttgctcagtg gactgggctc cccagggcct aggctgcctt cttttccatg tcccacccat 420 gagccctcca ctggacagct cagtaagcct ggcccttcat tctgcgctgt gttcttcctc 480 tgtgaaaatc caatacctct tacctcctct gcatgcaaag attctcaagg attgtcagac 540 ttcaaacgta acagcagaac caccagaagg tcctataaat gcagtagtga ccttctcaag 600 ctgtcanggc tttaaatagg atttgggatt taatgctatg tatttttaaa ggaaagaaat 660 agagttgcta gttttaaaaa tgcatgtctt ttaaccaatt cagaatctgg ccccnaactt 720 320 694 DNA Homo Sapien misc_feature (1)...(694) n = A,T,C or G 320 atgctcgagc ggncggcant gtgatggatn tctgcagaat tcgccctttc gagcggccgc 60 ccgggcaggt actattccgg atatacaaga tcactgggag atgttgatga tggagacaca 120 gtgacagatt tcatggccca agagcgagaa agaggcntta ctattcaatc agctgctgtt 180 acatttgatt ggaaaggtta tagagtcaat ctaattgata caccaggtca tgtggacttt 240 accttggagg ttgagcggtg cctaagagtg ttggatggtg cantggctgt atttgatgcc 300 tctgctggtg tagaggccca gactntcaca gtatggaggc aagctgataa acacaatata 360 cctcgaatct gttttttaaa caagatggac aaaactggag caagctttaa gtatgcagtt 420 gaaagcatca gagagaagtt aaaggcaaag cctttgcttt tacagttacc aattggtgaa 480 gccaaaactt tcaaaggagt ggtggatgta gtaatgaang aaaaacttct ttgggaattg 540 caattcaana tgatggaaaa gactttgaga gaaagcccct cttggaaatg aatgatcctg 600 aattgctgaa ggaaacaact gaacaaggaa tgccttaatt gaacaaagtt gcagatttgg 660 atgatgaatt tgctgacttg gttttaagaa gaat 694 321 781 DNA Homo Sapien misc_feature (1)...(781) n = A,T,C or G 321 gngttnacna ntgggccctc tngatgctgc tcgagcggcc gncagtgtga tggatntctg 60 cagaatncgc cctncgggcg gccgnccggg caggtactat nccggatata caagatcact 120 gggagatgtt gatgatggag acncagngac agatttcatg gcccaagagc gagaaagagg 180 cnttactatn caatcagctg ctgttacatt cgattggaaa ggttatngag tcaatctaat 240 tgatncacca ngtnatgtgg actttacctt ggaggttgag cggtgcctaa nagtgttgga 300 tggtgcanng gctgtatttg atgcctctgc tggtgtagag gcccagactc tcacagtatg 360 gatgcaagct gataaacaca atatacctng aatctgtgtt ttaaacaaga tggacaaaac 420 tggagcaagc tttaaagtnt gcagttgaaa gcatcagaga gangttnaag gcanagcctt 480 tgcttttaca gtttcccaat tgggtgaaac ccaaaacttt tcaaagggag ttggttggat 540 tgtaagtaat gaaaggaaaa acttctttgg gaaantggca atttcaanat gattggaaaa 600 ngacttttgg gagaaaagcc ccttcttggg aaaatngaaa tgatncctga aatttgcngt 660 aaanngaaaa cnaacntgna atccaangga attncccttt aanttggaac aaaggnttgc 720 naanttttng attgaatnga atttgncnga cntttnggtt ttangaaaga aattaaagng 780 g 781 322 744 DNA Homo Sapien misc_feature (1)...(744) n = A,T,C or G 322 gnnntganag tatcgactca ctatagggcg aattgggccc tctagatgca tgctcgagcg 60 gcccgccagt gtgatggata tctgcagaat tcgccctttc gagcggccgc ccgggcaggt 120 acgcggggac tgggtttttc tccttttgta gccttttcct ttagtctcct cttcccggtg 180 gttggtaaaa agaggtgaat tgacagccta tgttgaagac actgtgcttt tctcaagaag 240 gacatccaaa cagcaagtct acttctttct ctttaacgat gtgctcatta tcaccaagaa 300 gaagagtgaa gaaagttaca acgtcaatga ttattcctta agagatcagc tattggtgga 360 atcttgtgac aatgaagagc ttaattcttc tccagggaag aacagctcca caatgctcta 420 ttcaagacag agctctgcca gtcacctctt tactctgaca gtccttagta accacgcgaa 480 tgagaaagtg gagatgctac taggagctga gacgcagagc gagcgagccc gctggataac 540 tgccctggga cacagcagcg ggaagccgcc tgcagaccga acctnactga cccaggtgga 600 aatcgttagg tcatttactg ctaagcagcc agatgaactc ttcctgcagt ggctgacgtc 660 gtcctcatct atcaacgtgt cagcgatggc tggtatgaag gggaacgact tcgagatgga 720 gaaagaagnt gggttcctat ggaa 744 323 723 DNA Homo Sapien misc_feature (1)...(723) n = A,T,C or G 323 gtgtttcaan cggtcctcta gatgctgctc gagcggccgc cagtgtgatg gatatctgca 60 gaattcgccc tttcgagcgg ccgcccgggc aggtacgcgg ggactgggtt tttctccttt 120 tgtagccttt tcctttagtc tcctcttccc ggtggttggt aaaaagaggt gaattgacag 180 cctatgttga agacactgtg cttttctcaa gaaggacatc caaacagcaa gtctacttct 240 ttctctttaa cgatgtgctc attatcacca agaagaagag tgaagaaagt tacaacgtca 300 atgattattc cttaagagat cagctattgg tggaatcttg tgacaatgaa gagcttaatt 360 cttctccagg gaagaacagc tccacaatgc tctattcaag acagagctct gccagtcacc 420 tctttactct gacagtcctt agtaaccacg cgaatgagaa agtggagatg ctactaggag 480 ctgagacgca gagcgagcga gcccgctgga taactgccct gggacacagc agcgggaagc 540 cgctgcagac cgaacctcac tgacccaggt ggaaatcgtt aggtcattta ctgctaagca 600 gccagatgaa ctcttcctgc angtggctga cgtcgtcctc atctatcaac gtgtcancga 660 tggtggtatg aaggggaacg actacnagat ggagaaagaa gctggtttcc tatggaatgt 720 gcc 723 324 746 DNA Homo Sapien misc_feature (1)...(746) n = A,T,C or G 324 gggnttgaag ncncgactca ctatagggcg aattgggccc tctagatgca tgctcgagcg 60 gcccgccagt gtgatggata tctgcagaat tcgcccttag cgtggtcgcg gccgaggtac 120 cttgagatct gagcaactgt gttaatgaag taatagcaat ggtccacagt gaaagatgtg 180 ttggggtttg caaaacaagc attccgtcac ctctttaata atgtcacaga cttttttaaa 240 agagaggcta tcaagttgta atataatctg tcatgtttta tttaggaagg aaggtaaatt 300 tgtgcttgca cggggatcat tttgtattat ttntgctaat acccagttga agctaaaaag 360 caactatttg aatcctgtga attaatttat aagaatgtta aacagctntg gaaatacatg 420 catcttatga atcatagcct tatttagcaa gatcaatgtt aaagtgttga tatatggcaa 480 gtatttaaca cattcacagt gntagtttga tttcaactgt gaattgtctt acagtttttt 540 caaacctagt gtntctatgg acacctgctc tgaattgtac ccctcagtca ccaccaaagc 600 atttncaccc ctttcaaccc ccaatcagac cantgctttc agtggtattg gaggacttnt 660 atcacagctt catnangtgg tcttggcaca ggcagnctga ctngcttngg aactggtgct 720 tttggactcc cttcaanngn aatant 746 325 742 DNA Homo Sapien misc_feature (1)...(742) n = A,T,C or G 325 gtgtttcann cggccctcta gatgcatgct cgagcggccc gccagtgtga tggatatctg 60 cagaattcgc ccttagcgtg gtcgcggccg aggtaccttg agatctgagc aactgtgtta 120 atgaagtaat agcaatggtc cacagtgaaa gatgtgttgg ggtttgcaaa acatgcattc 180 cgtcacctct ttaataatgt cacagacttt tttaanagag aggctatcaa gttgtnatat 240 aatctgtcat gtattattta agaaggaagg taaatntgtg cttgcacggg gatcattttg 300 nattattnct gctnataccc agctgaagct nanaancnac tntttgnatc ctgtgantta 360 atncatanna atgttanaca gctntggaaa tccatgcctc ttatgaatca tngccttatt 420 tancangatc aatgttaaag ntgttgatat nnggcaagtn tntaacacat tnacantgct 480 agtntgattt caactgngaa ttgncttacc gtntttnnaa acctananga atntatngac 540 acctnctctn aatngnnncc ctcaancacc acnaaanctt ttncnnccct tncaaccccc 600 natcngaccn cngcattcag tngnaancng aangactttc atcacaactg gncaanatnt 660 nggactttgg cgccatgcnn accctcttgg nctttngaac nnggttgcct tttnggactt 720 tncncctgng ngataaccac cn 742 326 747 DNA Homo Sapien misc_feature (1)...(747) n = A,T,C or G 326 atgntttaag tatacgactc actatagggc gaattgggcc ctctagatgc atgctcgagc 60 ggccgccagt gtgatggata tctgcagaat tcgccctttc gagcggccgc ccgggcaggt 120 actgtatcat tggcagatgt gacgtcaccg acaaccagag tgaagtggcg gacaaaactg 180 aggattacct gtggctgaag ttgaaccaag tgtgttttga cgacgatggc accagctccc 240 cacaagacag gctcactctc tcacagttcc agaagcagtt gttggaagac tatggcgagt 300 cccactttac ggtgaaccag caacccttcc tctacttcca agtcctgttc ctgacagcgc 360 agtttgaagc agcagttgcc tttcttttcc gcatggagcg gctgcgctgc catgctgtcc 420 atgtagcact ggtgctgttt gagctgaagc tgcttttaaa gtcctctgga cagagtgctc 480 aactcctcag ccacgaacct ggtgaccctt cttgcttgcg gcggctgaac ttcgtgcggc 540 tcctcatgct gtacctcggc cgngaccacg ctaagggcga attccagcac actggcggnc 600 gttactagtg gatccgagct cggtaccaaa cttggcgtaa tcatggncat agctggttcc 660 tgtgtgaaat ggtatccgtt acaatttcac acaacatacg agccgggaag catnaagtgt 720 naaacctggg gtgcctnatg agtgacn 747 327 724 DNA Homo Sapien misc_feature (1)...(724) n = A,T,C or G 327 gtnatgaaac cnttctntng ngcatgctcg agcggccgcc agtgtgatgg atatctgcag 60 aattcgccct ttcgagcggc cgcccgggca ggtactgtat cattggcaga tgtgacgtca 120 ccgacaacca gagtgaagtg gcggacaaaa ctgaggatta cctgtggctg aagttgaacc 180 aagtgtgttt tgacgacgat ggcaccagct ccccacaaga caggctcact ctctcacagt 240 tccagaagca gttgttggaa gactatggcg agtcccactt tacggtgaac cagcaaccct 300 tcctctactt ccaagtcctg ttcctgacag cgcagtttga agcagcagtt gcctttcttt 360 tccgcatgga gcggctgcgc tgccatgctg tccatgtagc actggtgctg tttgagctga 420 agctgctttt aaagtcctct ggacagagtg ctcagctcct cagccacgag cctggtgacc 480 ctccttgctt gcggcggctg aacttcgtgc ggctcctcat gctgtacctc ggccgcgacc 540 acgctaaggg cgaattccag cacactggcg gccgttacta gtggatccga gctcggtacc 600 aagcttggcg taatcatggt catagctgtt tcctgtgtga aattgtatcc gctcacaatt 660 ncacacaaca tacgagccgg aagcataaag tgtaaaacct ggggtgccta atgagtgaac 720 taan 724 328 747 DNA Homo Sapien misc_feature (1)...(747) n = A,T,C or G 328 tgnntgttag atacgactca ctatagggcg aattgggccc tctagatgca tgctcgagcg 60 gcccgccagt gtgatggata tctgcagaat tcgcccttag cgtggtcgcg gccgaggtac 120 tttttttttt ttttttaaag acagagtctt gctctgtcac ccaggctgga gtgcagtggc 180 acgatctcgg ctcactgcaa gctctgcctc ccgggttcac gccattctcc tgcctcagcc 240 tcccgagtag ctgggactac aggtgcccgc caccatgccc ggctgatttc tttttgtatt 300 tttagtagag acggagtttc accgtgttag ccaggatggt ctcgatctcc tgacctcgtg 360 atccgcccgc cttggcctcc aaagtgctgg gattacaggt gtgagctacc gcgcccggcc 420 tattatcttg tactttctaa ctgagccctc tattttcttt attttaataa tatttctccc 480 cacttgagaa tcacttgtta gttcttggta ggaattcagt tgggcaatga taacttttat 540 gggcaaaaac attctattat agtgaacaaa tgaaaataac agcgtatttt caatattttc 600 ttattcctta aattccactc ttttaacact atgcttaacc acttaatgtg atgaaatatt 660 cctaaaagtt aaatgactat taaagcatat attggtgcat gnatatatta aagtacccga 720 tactctaaat aaaaatccac tggtccn 747 329 725 DNA Homo Sapien misc_feature (1)...(725) n = A,T,C or G 329 gcgtttcaan tgggccctct ngngcatgct cgagcggccg ccagtgtgat ggatatctgc 60 agaattcgcc cttagcgtgg tcgcggccga ggtacttttt tttttttttt taaagacaga 120 gtcttgctct gtcacccagg ctggagtgca gtggcacgat ctcggctcac tgcaagctct 180 gcctcccggg ttcacgccat tctcctgcct cagcctcccg agtagctggg actacaggtg 240 cccgccacca tgcccggctg atttcttttt gtatttttag tagagacgga gtttcaccgt 300 gttagccagg atggtctcga tctcctgacc tcgtgatccg cccgccttgg cctccaaagt 360 gctgggatta caggtgtgag ctaccgcgcc cggcctatta tcttgtactt tctaactgag 420 ccctctattt tctttatttt aataatattt ctccccactt gagaatcact tgttagttct 480 tggtaggaat tcagttgggc aatgataact tttatgggca aaaacattct attatagtga 540 acaaatgaaa ataacagcgt attttcaata ttttcttatt ccttaaattc cactctttta 600 acactatgct taaccactta atgtgatgaa atattcctaa aagttaaatg actattaaag 660 catatattgg tgcatgtata tattaagtag cccgatctct naataaaaat ccactggtac 720 agata 725 330 741 DNA Homo Sapien misc_feature (1)...(741) n = A,T,C or G 330 gnnntganag atacgactca ctatagggcg aattgggccc tctagatgca tgctcgagcg 60 gcccgccagt gtgatggata tctgcagaat tcgcccttag cgtggtcgcg gccgaggtac 120 tttttttttt tttttttttt tttttttttt ggaagtttaa tttactcaca gttcaacatg 180 gctggggagg cctcaggaaa tttacaatta taacagaagg caaaggggaa gccagatacc 240 ttcttcacaa ggtggcagga aggagaagag ccgagagaag gcggaagaat cccttataaa 300 accatcagat ctcgtgagaa ctcacttgct atcaggagaa cagcatgggg gaaccgcccc 360 caggattcaa tgacctncac ctggtctctc ccttgacacg tgaggattat ggggattaca 420 attccagatg agatttgggt ggggacacaa agccaaacca tatcaactgt gactaccttg 480 ggtaagggcc atccaggcag aggcaggggg aacattctgg gcaaaggcct tggggcaggg 540 gcctggtatg ttcagatagc ancaagtagg ccagantggc cggaggggag taagtgtggg 600 gaggccagtg ganagatgag ggtagggaag ggatggatca gatcatgcag ggccccgggg 660 gccacaggaa ngacctnagc atttactgca agtaangtgg gaaccatcga atgtctaagc 720 naggaggaat ccctgtgact c 741 331 727 DNA Homo Sapien misc_feature (1)...(727) n = A,T,C or G 331 gtnnnncgan ngggccctct agatgcatgc tcgagcggcc gccagtgtga tggatatctg 60 cagaattcgc ccttagcgtg gtcgcggccg aggtactttt tttttttttt tttttttttt 120 ttttttggaa gtttaattta ctcacagttc aacatggctg gggaggcctc aggaaattta 180 caattataac agaaggcaaa ggggaagcca gataccttct tcacaaggtg gcaggaagga 240 gaagagccga gagaaggcgg aagaatccct tataaaacca tcagatctcg tgagaactca 300 cttgctatca ggagaacagc atgggggaac cgcccccagg attcaatgac ctccacctgg 360 tctctccctt gacacgtgag gattatgggg attacaattc cagatgagat ttgggtgggg 420 acacaaagcc aaaccatatc aactgtgact accttgggta agggccatcc aggcagaggc 480 agggggaaca ttctgggcaa aggccttggg gcaggggcct ggtatgttca gatagcagca 540 agtaggccag antggccgga ggggagtaag tgtggggagg ccagtggaaa aatganggta 600 gggaaaggga tggatcagat catgcagggc cccgggggcc acangaagga cctnacattt 660 actgcaagta angtgggagc catcgaatgt tctaagcana ngangaatcc ctgngactca 720 ngtgttn 727 332 734 DNA Homo Sapien misc_feature (1)...(734) n = A,T,C or G 332 gnntganagt atacgactca ctatagggcg aattgggccc tctagatgca tgctcgagcg 60 gcccgccagt gtgatggata tctgcagaat tcgccctttc gagcggccgc ccgggcaggt 120 acccttctcg cttttgccat tagccaagga tagaagctgc agtggtatta attttgatat 180 aatctttcaa accagcttca tgtggcttcc cttttctttg ttcaagatga gggccaggag 240 gggaaacatc acacctgccc taaaccctgt tcctggaggt cagcatttga tctgttgcaa 300 gcccctcttt ctgtcccctc ttcctaccct gcctcccatg actttgctcc tcacactttt 360 ggaaccatgc cttccggggg ggcccatctc ttctggccgt ccttgtctct gggccacttg 420 gagtgtgtga taaatcagtc aagctgttga agtctcagga gtctctggta gcctgcagaa 480 gtaagcctca tcatcagagc ctttcctcaa aactggagtc ccaaatgtca tcaggttttg 540 nttttttttc aaccactaag aacccctctg cttttaactc tagaatttgg gcttggacca 600 gatctaacat cttgaatact ctgccctcta gaccttcacc ttaatggaan gtggatccca 660 nganggtgta atggacatca agccactcgc ggcagcatgg agctatacta agcatcctta 720 nggtctgcct ctcn 734 333 710 DNA Homo Sapien misc_feature (1)...(710) n = A,T,C or G 333 ntgggccctc tngngctgct cgagcggccg ccagtgtgat ggatatctgc agaattcgcc 60 ctttcgagcg gccgcccggg caggtaccct tctcgctttt gccattagcc aaggatagaa 120 gctgcagtgg tattaatttt gatataatct ttcaaaccag cttcatgtgg cttccctttt 180 ctttgttcaa gatgagggcc aggaggggaa acatcacacc tgccctaaac cctgttcctg 240 gaggtcagca tttgatctgt tgcaagcccc tctttctgtc ccctcttcct accctgcctc 300 ccatgacttt gctcctcaca cttttggaac catgccttcc gggggggccc atctcttctg 360 gccgtccttg tctctgggcc acttggagtg tgtgataaat cagtcaagct gttgaagtct 420 caggagtctc tggtagcctg cagaagtaag cctcatcatc agagcctttc ctcaaaactg 480 gagtcccaaa tgtcatcagg ttttgttttt ttttcagcca ctaagaaccc ctctgctttt 540 aactctagaa tttgggcttg gaccagatct aacatcttga atactctgcc ctctagagcc 600 ttcagcctta atggaagggt ggatccaang anggtgtaat ggaacatcaa gccactcgcg 660 gcagcatgga gctatactaa gcatccttta nggtctgcct cttcagcatt 710 334 2051 DNA Homo sapien misc_feature (1)...(2051) n = A,T,C or G 334 gcccttgcct cagcctaccc agtagctggt gatggccatc cttttataaa tgcaacgtcc 60 ttcgttcctg ttaagtcatg ggggaggaag gccttttctc tcttcagtct aataatcaac 120 tgttcactat tcacaatagc aacatcatgg gctgaaccta tgtgtccatc aacagatgat 180 tagattttaa aatgtgcata tataccatgg aatacatacg caaccatcaa aaataatgaa 240 atcacatctt ttgcagcaat atggatggaa ctggaagccc ttatcgtaag tgaaatgact 300 cagagacaga aagtcagaaa ctgcatgttc tcatttggaa actgaaaatc acacacacat 360 aaatctaata aagacatggg tactttattt tcaaaacact catatgttgc aaaaaacaca 420 tagaaaaata aagtttggtg ggggtgctga ctaaacttca agtcacagac ttttatgtga 480 cagattggag cagggtttgt tatgcatgta gagaacccaa actaatttat taaacaggat 540 agaaacaggc tgtctgggtg aaatggttct gagaaccatc caattcacct gtcagatgct 600 gatagactag ctcttcagat gtttttctac cagttcagag atgggttaat gactagttcc 660 aatggggaaa aagcaagatg gattcacaaa ccaagtaatt ttaaacaaag acactttttt 720 ttttttttgc aacacaatat acatcacagt gaaatgtgta atccttgcaa attgcaagtt 780 gaaagaatta aattcagagg aggggagaga aagagtactc agtagggact gagcactaaa 840 tgcttatttt aaaagaaatg taaagagcag aaagcaattc aggctaccct gccttttgtg 900 ctggctagta ctccggtcgg tgtcagcagc acgtggcatt gaacattgca atgtggagcc 960 caaaccacag aaaatggggt gaaattggcc aactttctat taacttatgt tggcaatttt 1020 gccaccaaca gtaagctggc ccttctaata aaagaaaatt gaaaggtttc tcactaaacg 1080 gaattaagta gtggagtcaa gagactccca ggcctcagcg tacctcatta gtaattgttt 1140 tgttgtttca tttttttcta atgtctcccc tctaccagct cacctgagat aacagaatga 1200 aaatggaagg acagccagat ttctcctttg ctctctgctc attctctctg aagtctaggt 1260 tacccatttt ggggacccat tataggcaat aaacacagtt cccaaagcat ttggacagtt 1320 tcttgttgtg ttttagaatg gttttccttt ttcttagcct tttcctgcaa aaggctcact 1380 cagtcccttg cttgctcagt ggactgggct ccccagggcc taggctgcct tcttttccat 1440 gtcccaccca tgagccctcc actggacagc tcagtaagcc tggcccttca ttctgcgctg 1500 tgttcttcct ctgtgaaaat ccaatacctc ttacctcctc tgcatgcaaa gattctcaag 1560 gattgtcaga cttcaaacgt aacagcagaa ccaccagaag gtcctataaa tgcagtagtg 1620 accttctcaa gctgtcaggt ctttaaatag gatttgggat ttaatgctat gtatttttaa 1680 aggaaagaaa taagagttgc tagtwttaaa aatgcatgtc ttttagccaa ttcagaatct 1740 gcccccaaac ttttttaaaa agtcaagaca gataaagctt tggggagacg gaaaaaaaaa 1800 aaaaaaaaaa aacaagtacc tcggccgcga ccacgctaag ggcgaattcc agcacactgg 1860 cggccgttac tagtgggttc nanncccggt acnaancctt gggggtttaa caagggcnaa 1920 ancnggttnc cggggntnaa aattgttacc cgcnaaaaat tccanaaaaa natncgaacc 1980 cggaaancca taaanttntn aancccnggn ggccnaaggg agngnnnaac cccnaataaa 2040 tggnttggnc c 2051 335 1312 DNA Homo sapien 335 acctagaaaa cagaaacttg agtagacatg gtaatgacca gaaaaggcta tctttataca 60 tttcttttgc tacgcttcaa attcatgtca cctaaaagtt gtgaagtgca caaaacaaat 120 ctacttaact gaaaattatt ttcaatgaat gggatgttta gaactctgtg agggttttta 180 aggtcttttc gaatagcaaa ttctaatgag gcttttttaa gttggcaatt taaactcata 240 caagaaataa aaactcacca gtgtggctgg gcagaatata tatattttct caaatattgt 300 ttgtttgttt tttccctgca ctgtatccat ggtcccatga tgaaactgtt atattgctga 360 tatatttatt ggaatatgtg ggccaacttc ctttccactc aacatatgga ttggtagttt 420 aaaataattc ctttctatta agcaaatgtg tggctaaggc acatttaaat agcccattaa 480 accaatgaga tgacaatgtg ttaccctcag agaaagctta atttttggag taatcaatta 540 cacatatcac agaatgtctc atgagaacat ttttggctag gtctaccaat ttatcatgca 600 aataattata gattttcatt tgaggcaaag atgctgattc atcattagta acatggtcac 660 aaataatcat ttattttatt tttgttaaca tctgtctttc ctgtggggaa acttactata 720 tgctctacgt ttatttaatt taaaaagtca attggttatt ctgaattttt aaaaataaca 780 taaaactgtt gttctaaatc acagcacctg cttttctttt tttagtgaaa ttatataagc 840 atttagagaa tgaaagtgta agacttgtgg tttctggtct ctttttactg tttgtaagcc 900 tactcgtcat gatattccac aatggtgcac ttgcctttta atgctcttat agatatcttc 960 aaacttgcct acatatatac gcctttgttg gagtgggcta ccatcatcag gaatgatgtc 1020 atttgtttct tcaaactcct ttattatacc aaaaaagtga cagactccac agtctgatca 1080 gttttggaga aatatgttaa cattttcaat tatctcactt tctagaatca aaatagtctg 1140 attttttttt ttcggcactc agtgtaaaga acaaagaact gaatacagtg ggcccagaag 1200 agaaatatgc ctcatcattt ttattagctt tggaactgtg gacaagtcac tcaacctagt 1260 tttctcattt tgaaatgggt tgttgtggga attaaaaaaa aaaaaaaaaa gt 1312 336 787 DNA Homo sapien 336 acagccatga aattgttgct actcatagaa agtcttagta tagtttggtt taaacatttt 60 aaaattgcaa ataaatatag atagataata tcatgatgag aaggtcacgg gaagcctgga 120 gatttcaggg tgctctttca taattggagc gagaatcatg taacagttaa gaaactaaac 180 tcttgagcct tcatagtctt tgctttctcc ccatttattt atctgatatt atataccctc 240 tttaattata gactggactg aaatatttta tttttgtttt attataaaaa atcctactcg 300 tctttaacat gttctcttaa agagtgtttc atatataaat actttccccc caaaatataa 360 agaggctaac cactatagta ttgaaagatt gaaagaaaga cctagggtgt ctaaaaccaa 420 atttaaaggc tcagttctaa gaggagttaa aatgcttcct ttgtaagcac tttaaacttc 480 atctttaaac attgatgaga atattataaa gaattcacaa cagcagttac atggaggtag 540 aaaagagtgt tgagaagaag gagggtgatt gcaacaaata caaagaaact attgagatgt 600 aacaaagacg tgcaattacc tatgaatggg taaaccagtt atatattttg ctttcacagc 660 atgagattat ttttaatttg aattggttta ccatgtaatg acacttccat tttaaagatt 720 ttatgcatgt aaccttaata ctctcaaggt ttccagactt cagagaggta gctcatactt 780 tcattgt 787 337 772 DNA Homo sapien 337 acatcagtgt tcattttatt atttcttaca ctgtcttcat gacttacaca taatattttg 60 ctagttttaa aacataagat gtgataataa tctaaacaga ccaaaggaaa taaatgaata 120 tgattaaaaa aagacagaga ataagccctg tctgatggaa agcataacaa agcaggtaga 180 acaactgtca ggaatgcttg atccaataaa gctaggtttg tgatccacaa cacttcagca 240 ttttaatgtg atttttgatg tttgcttttt gcaatggtga ttctcagttg cctccctcct 300 gtgtctttac aagctgaaat caagtgaagc tacttctgac tttttctaaa acttaaaccc 360 aacatgaagg tctgcgtatt ctttcacatg tgcacgtatg tggcactttt ccatgatgca 420 acagcagcgg gtctctagct aagctacagc agcagctcta agaggcagag gaccctgaaa 480 tgaggctgaa agaaagaata gtccataact gacatcaggc aggctgctgt tgtaagcaca 540 gaaaggaggc tcacggcggc atggactcag gccaggtcac actattgtgg gagaacacgg 600 agcacacgtg tcagctggaa aggggccggc tcaggagaca aaataggcac gagaggaaac 660 cgaaaaattg acatatgtga ctatccttgt agaaatgtat aaaggtttgg attattttgc 720 ttatcgagtt ataataaagt tattctaaaa atgtttatct aaagtattat gt 772 338 1383 DNA Homo sapien 338 ttactcacta tagggctcga gcggccgccc gggcaggtgt aaaaataaaa tgacagtttg 60 aacatacaaa acccacccca ttcctataga gcctagtact acactacccc ctcccaactt 120 tagcctccac atatagtaat gtgcttggaa cacaaaaaac acttcataaa ttgtgctgaa 180 tgaaatcatt tccatgagtg tttatggatt ttgagttcat ttgtaccttt tacctaaaat 240 tctagccact ttaatttgga gagtttccag agcaaaggac cttttaccta aaattctagc 300 cactttaatt tggagagttt ccagagcaaa gggcacagat cccaggcata acaacgcttt 360 gcgtatacag caaccaatat cttgtcaacc caagaaagtt cctccattga tacctagtag 420 aaatagccca gtttttaaag tcctcaaaac tgtaacaaat tacttgtttt taaaatttaa 480 cttaaattaa tacaatcaga tttttgtgtt atttgggtat tagagtatgt taaagcacat 540 atatcccaga gacatagagt ttccgtttca aaaagtcatg cattcatgtg tgctaatgac 600 aatcctatcc tgacccgcta tgtgacttgt atctctaaac cataggcttt cctgaatttt 660 atctgttaat ttaaccctga tttctcagca gcagcttctc tttgtaaata gacttgcctc 720 ttctgtgtct gacctctgct cctcataatc agattaactc agataaagct gcttcaggga 780 agaggtcaaa accgttgcca aaaatagtag ttgccctact tcagtctatt ttcaacagag 840 tagccaggag atcctgttca caccaaagtc caatcagccc tactgttagc actctgctca 900 caagcctcca gtggcttccg acctcactca cagtaaaagc caagtcatcc tttagcctat 960 gatgtcctac atgatttgaa ttcccttcca ttgatttttg tcactgattt ttaaaaatcc 1020 aaattcattc tcatacagct gaattgtcct ctttgcttta agtatgccag gattatttct 1080 acctcagggc ctttgcactt gatattccct tcaccttttc caagatagtt attccctcac 1140 ctcagtcaag cctttattta gatgccccct tctcatcaag gcattctctg atctccttat 1200 ttaaatgtat gacacccctt ctttgcttta catttaatca gaacatgtgt cactatctag 1260 catataatac atttgcttga cctcttttgt ttactgtcta tgcctcctga atactgtgta 1320 agctccacga tacaggcact tttctctatt tcgagcactg ttgtattaca gagccttaaa 1380 agt 1383 339 1815 DNA Homo sapien 339 actttttgtt cattttgatt tttggataat gcaaaattat agatttttta aaaattatat 60 tcaaagaata ctgagtgcaa gacaatcttt ctaggttaaa aaatatctta taaacctgaa 120 ttgtcaatta ttattgtatc ccagatgtat ggaagttaat ggatagtcag taacatacag 180 gactagcaga aggtttgttg ttataggtaa tctggagaga agccaggtaa gtggaatttg 240 ggatttgctg ctgttgccag aaagcagcac agagacatgg taagtggcaa gacccaggta 300 actaaaacaa ccatgtctta gtccttttat gctgctgtaa cagaatatca cagactgagt 360 aatttataat gaacagaact ttatttgtct tctggttctg gagactggga aatctaagag 420 cgtggcattg acatatggtg agggcatttg tgcctcatca tcccatgaca gaagatggaa 480 atgcaagaga gctcaaaagc aagagagcaa atggggccaa acttgctttt tataacaagc 540 cactcttgtg ataatgaacc aactcaaaca ataaagacat aaatccattc atgagggcag 600 agccctcaag gatgaatcac ttcacttctt aatggcctca gcttctaata ccatcacaat 660 agtaattcag tttcaacatg ggttttatag ggacgttgga accacagcaa actgtaacca 720 ttttgatttc cttatttgca ccattttaaa aaaacctatt tatttaacga ctgtttattc 780 agtgcctatt ctgttgtgtt ggggactaga ggtaattaca aagggaataa gacaaacagt 840 cacccactct ggtgatgctt cccttatctt cataatgcat ttgatcctgt gattctttgg 900 cacatgagtc cattgcatct tgcatattag tgtccagtaa gtttttcctg accaattgat 960 aatatagata tacattggta gcagttttgt gtatattttt atagttagat gttgttggca 1020 catgtgactt gtgtctcaga aaaatacaga aaatggttaa agacaggagg atactaccct 1080 gatttctctg ttcattaaag aacagctatt tggggggaaa acctgataca attatttgag 1140 catgtggctt aaagattaga cctataaaca attcaggagc atcttccagc aaactgtgtg 1200 agaattcaca gaaataaacc tggtaggttt gtgctatgtt attcacatgg gctgttaact 1260 cttttccatt cctaggtcct ttatttccct gccctcctca atctcatgct cttgagattt 1320 ttaactatat tacttcttta caaagtcatc ttcaaaatga ttcattttgg atagcaaact 1380 atccctcaac ttacctacac actctcactc atactcacat tctctcttat gtctttctgt 1440 gtggaaggga acatttagaa tgtctattct ttgtgatgca aaaatgacaa cacactgatg 1500 atgaaggggg gtatttttag gagaaaaagt agcttttctt ttcatcatac tgccactttt 1560 gagattctat agaaagaata ggtattgaac acagaccact tggctctctg aggtatgctt 1620 tggacacact tagaagtcag ctagaatatg ccttctgttt aaggttggag tctgcattta 1680 aaaagagaga actggattaa ttggcaggta agttgagatt ccatgattca ggaaaccttt 1740 aagactttta agtgcaggct ctttgtaggt tggaatgaaa cttaatatat atatatgttc 1800 tttgattctt tctgt 1815 340 22 PRT Homo sapiens 340 Cys Gly Pro Arg Leu Pro Ser Phe Pro Cys Pro Thr His Glu Pro Ser 1 5 10 15 Thr Gly Gln Leu Ser Lys 20 341 23 PRT Homo sapiens 341 Cys Lys Asp Ser Gln Gly Leu Ser Asp Phe Lys Arg Asn Ser Arg Thr 1 5 10 15 Thr Arg Arg Ser Tyr Lys Cys 20

Claims

We claim:

1. A method of diagnosing cancer, tumor progression, hyperproliferative cell growth or accompanying biological and physical manifestations comprising:

(a) providing a polynucleotide probe that comprises a sequence capable of hybridizing to any one of the sequences shown in SEQ ID NO:1-339 or complement thereof;

(b) contacting a biological sample for diagnosis with said probe under hybridizing conditions that permit formation of a duplex; and

(c) determining the presence of said duplex.

2. The method of claim 1, wherein said polynucleotide probe comprises at least eight contiguous nucleotides of any of SEQ ID NO:1-339 or complement thereof.

3. The method of claim 2, wherein said polynucleotide probe comprises 8 contiguous nucleotides of the sequences of the clones selected from the group consisting of SL-5, SL-6, SL-9, SL-11, SL-13, SL-68, SL-69, SL-86, SL-90, SL-10O, SL-107, SL-124, SL-135, SL-139, SL-143, SL-152, SL-153, SL-173, SL-177, SL-195, and SL-197.

4. A method of diagnosing cancer, tumor progression, or hyper-proliferative cell growth comprising.

(a) providing an antibody capable of binding to a polypeptide encoded by any one of SEQ ID NO:1-339 or complement thereof;

(b) contacting a biological sample for diagnosis with said antibody under binding conditions that permit formation of an antibody-polypeptide complex; and

(c) determining the presence of said complex.

5. The method of claim 4, wherein said antibody is capable of binding to a polypeptide comprising at least six contiguous amino acid of a polypeptide encoded by any one of SEQ ID NO:1-339 or complement thereof.

6. The method of claim 5, wherein said polypeptide comprises at least six contiguous amino acids of a polypeptide encoded by any one the sequences of the clones selected from the group consisting of SL-5, SL-6, SL-9, SL-1 1, SL-13, SL-68, SL-69, SL-86, SL-90, SL-100, SL-107, SL-124, SL-135, SL-139, SL-143, SL-152, SL-153, SL-173, SL-177, SL-195, and SL-197.

7. A diagnostic kit comprising:

(a) a diagnostic reagent comprising a polynucleotide probe that comprises a sequence capable of hybridizing to any one of SEQ ID NO:339 or complement thereof when said sequence is present in a test biological sample;

(b) a normal biological sample; and

(c) instructions for detecting differences that exist between the levels of duplexes in said test biological sample as compared to said normal biological sample.

8. A method of treating a mammal with cancer, tumor progression, hyperproliferative cell growth or accompanying biological and physical manifestations, said method comprising administering to said mammal a composition that comprises a therapeutically effective amount of a polynucleotide comprising a sequence capable of hybridizing under stringent conditions to any one of SEQ ID NO:1-339 or complement thereof.

9. The method of claim 8, wherein said polynucleotide comprises at least eight contiguous nucleotides of any of SEQ ID NO:1-339 or complement thereof.

10. The method of claim 9, wherein said polynucleotide is an antisense construct.

11. The method of claim 9, wherein said polynucleotide is a ribozyme construct.

12. An isolated polynucleotide selected from the group consisting of

(a) a polynucleotide comprising the nucleotide sequence of any one of SEQ ID NO:2, 5, 49, 50, 99, 100, 115, 116, 118, 130, 131, 140, 144, 145, 146, 157, 158, 159, 163, 164, 165, 166, 177, 178, 180, 211, 212, 213, 218, 219, 220, 221, 229, 232, 233, 242, 243, 248, 249, 254, 256, 257, 259, 272, 273, 277, 288, 289, 292, 293, 316, 317, and 330;

(b) a polynucleotide encoding a variant of the polypeptide encoded by (a); and

(c) a polynucleotide encoding a protein expressed by a polynucleotide having the sequence of at least one of sequences of (a).

13. A vector comprising the polynucleotide of claim 12.

14. A host cell comprising the vector of claim 13.

15. A composition comprising a polypeptide, wherein the polypeptide is selected from the group consisting of:

(a) a polypeptide encoded by any one of the polynucleotides of claim 12, and

(b) a variant of the polypeptide of (a).