US20020142378A1

US20020142378A1 - Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof

Info

Publication number: US20020142378A1
Application number: US09/813,320
Authority: US
Inventors: Hongyu Zhang; Chunhua Yan; Valentina Di Francesco; Ellen Beasley
Original assignee: Applera Corp
Current assignee: Applied Biosystems LLC
Priority date: 2001-03-21
Filing date: 2001-03-21
Publication date: 2002-10-03
Also published as: WO2002077261A3; AU2002252428A1; EP1381623A4; CA2441721A1; WO2002077261A2; EP1381623A2; US20050130218A1

Abstract

The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.

Description

FIELD OF THE INVENTION

The present invention is in the field of transporter proteins that are related to the Erg potassium channel subfamily, recombinant DNA molecules, and protein production. The present invention specifically provides a novel alternative splice form of an Erg potassium channel protein that effects ligand transport and nucleic acid molecules encoding the alternative splice form, all of which are useful in the development of human therapeutics and diagnostic compositions and methods.

BACKGROUND OF THE INVENTION

Transporters

Transporter proteins regulate many different functions of a cell, including cell proliferation, differentiation, and signaling processes, by regulating the flow of molecules such as ions and macromolecules, into and out of cells. Transporters are found in the plasma membranes of virtually every cell in eukaryotic organisms. Transporters mediate a variety of cellular functions including regulation of membrane potentials and absorption and secretion of molecules and ion across cell membranes. When present in intracellular membranes of the Golgi apparatus and endocytic vesicles, transporters, such as chloride channels, also regulate organelle pH. For a review, see Greger, R. (1988) Annu. Rev. Physiol. 50:111-122.

Transporters are generally classified by structure and the type of mode of action. In addition, transporters are sometimes classified by the molecule type that is transported, for example, sugar transporters, chlorine channels, potassium channels, etc. There may be many classes of channels for transporting a single type of molecule (a detailed review of channel types can be found at Alexander, S. P. H. and J. A. Peters: Receptor and transporter nomenclature supplement. Trends Pharmacol. Sci., Elsevier, pp. 65-68 (1997) and http://www-biology.ucsd.edu/˜msaier/transport/titlepage2.html.

The following general classification scheme is known in the art and is followed in the present discoveries.

Channel-Type Transporters.

Transmembrane channel proteins of this class are ubiquitously found in the membranes of all types of organisms from bacteria to higher eukaryotes. Transport systems of this type catalyze facilitated diffusion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. These channel proteins usually consist largely of a-helical spanners, although b-strands may also be present and may even comprise the channel. However, outer membrane porin-type channel proteins are excluded from this class and are instead included in class 9.

Carrier-Type Transporters.

Transport systems are included in this class if they utilize a carrier-mediated process to catalyze uniport (a single species is transported by facilitated diffusion), antiport (two or more species are transported in opposite directions in a tightly coupled process, not coupled to a direct form of energy other than chemiosmotic energy) and/or symport (two or more species are transported together in the same direction in a tightly coupled process, not coupled to a direct form of energy other than chemiosmotic energy).

Pyrophosphate Bond Hydrolysis-Driven Active Transporters.

Transport systems are included in this class if they hydrolyze pyrophosphate or the terminal pyrophosphate bond in ATP or another nucleoside triphosphate to drive the active uptake and/or extrusion of a solute or solutes. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated.

Pep-Dependent, Phosphoryl Transfer-Driven Group Translocators.

Transport systems of the bacterial phosphoenolpyruvate:sugar phosphotransferase system are included in this class. The product of the reaction, derived from extracellular sugar, is a cytoplasmic sugar-phosphate.

Decarboxylation-Driven Active Transporters.

Transport systems that drive solute (e.g., ion) uptake or extrusion by decarboxylation of a cytoplasmic substrate are included in this class.

Oxidoreduction-Driven Active Transporters.

Transport systems that drive transport of a solute (e.g., an ion) energized by the flow of electrons from a reduced substrate to an oxidized substrate are included in this class.

Light-Driven Active Transporters.

Transport systems that utilize light energy to drive transport of a solute (e.g., an ion) are included in this class.

Mechanically-Driven Active Transporters.

Transport systems are included in this class if they drive movement of a cell or organelle by allowing the flow of ions (or other solutes) through the membrane down their electrochemical gradients.

Outer-Membrane Porins (of B-Structure).

These proteins form transmembrane pores or channels that usually allow the energy independent passage of solutes across a membrane. The transmembrane portions of these proteins consist exclusively of b-strands that form a b-barrel. These porin-type proteins are found in the outer membranes of Gram-negative bacteria, mitochondria and eukaryotic plastids.

Methyltransferase-Driven Active Transporters.

A single characterized protein currently falls into this category, the Na+-transporting methyltetrahydromethanopterin:coenzyme M methyltransferase.

Non-ribosome-synthesized channel-forming peptides or peptide-like molecules. These molecules, usually chains of L- and D-amino acids as well as other small molecular building blocks such as lactate, form oligomeric transmembrane ion channels. Voltage may induce channel formation by promoting assembly of the transmembrane channel. These peptides are often made by bacteria and fungi as agents of biological warfare.

Non-Proteinaceous Transport Complexes.

Ion conducting substances in biological membranes that do not consist of or are not derived from proteins or peptides fall into this category.

Functionally Characterized Transporters for which Sequence Data are Lacking.

Transporters of particular physiological significance will be included in this category even though a family assignment cannot be made.

Putative Transporters in which no Family Member is an Established Transporter.

Putative transport protein families are grouped under this number and will either be classified elsewhere when the transport function of a member becomes established, or will be eliminated from the TC classification system if the proposed transport function is disproven. These families include a member or members for which a transport function has been suggested, but evidence for such a function is not yet compelling.

Auxiliary Transport Proteins.

Proteins that in some way facilitate transport across one or more biological membranes but do not themselves participate directly in transport are included in this class. These proteins always function in conjunction with one or more transport proteins. They may provide a function connected with energy coupling to transport, play a structural role in complex formation or serve a regulatory function.

Transporters of Unknown Classification.

Transport protein families of unknown classification are grouped under this number and will be classified elsewhere when the transport process and energy coupling mechanism are characterized. These families include at least one member for which a transport function has been established, but either the mode of transport or the energy coupling mechanism is not known.

Ion channels

An important type of transporter is the ion channel. Ion channels regulate many different cell proliferation, differentiation, and signaling processes by regulating the flow of ions into and out of cells. Ion channels are found in the plasma membranes of virtually every cell in eukaryotic organisms. Ion channels mediate a variety of cellular functions including regulation of membrane potentials and absorption and secretion of ion across epithelial membranes. When present in intracellular membranes of the Golgi apparatus and endocytic vesicles, ion channels, such as chloride channels, also regulate organelle pH. For a review, see Greger, R. (1988) Annu. Rev. Physiol. 50:111-122.

Ion channels are generally classified by structure and the type of mode of action. For example, extracellular ligand gated channels (ELGs) are comprised of five polypeptide subunits, with each subunit having 4 membrane spanning domains, and are activated by the binding of an extracellular ligand to the channel. In addition, channels are sometimes classified by the ion type that is transported, for example, chlorine channels, potassium channels, etc. There may be many classes of channels for transporting a single type of ion (a detailed review of channel types can be found at Alexander, S. P. H. and J. A. Peters (1997). Receptor and ion channel nomenclature supplement. Trends Pharmacol. Sci., Elsevier, pp. 65-68 and http://www-biology.ucsd.edu/˜msaier/transport/toc.html.

There are many types of ion channels based on structure. For example, many ion channels fall within one of the following groups: extracellular ligand-gated channels (ELG), intracellular ligand-gated channels (ILG), inward rectifying channels (INR), intercellular (gap junction) channels, and voltage gated channels (VIC). There are additionally recognized other channel families based on ion-type transported, cellular location and drug sensitivity. Detailed information on each of these, their activity, ligand type, ion type, disease association, drugability, and other information pertinent to the present invention, is well known in the art.

Extracellular ligand-gated channels, ELGs, are generally comprised of five polypeptide subunits, Unwin, N. (1993), Cell 72: 31-41; Unwin, N. (1995), Nature 373: 37-43; Hucho, F., et al., (1996) J. Neurochem. 66: 1781-1792; Hucho, F., et al., (1996) Eur. J. Biochem. 239: 539-557; Alexander, S. P. H. and J. A. Peters (1997), Trends Pharmacol. Sci., Elsevier, pp. 4-6; 36-40; 42-44; and Xue, H. (1998) J. Mol. Evol. 47: 323-333. Each subunit has 4 membrane spanning regions: this serves as a means of identifying other members of the ELG family of proteins. ELG bind a ligand and in response modulate the flow of ions. Examples of ELG include most members of the neurotransmitter-receptor family of proteins, e.g., GABAI receptors. Other members of this family of ion channels include glycine receptors, ryandyne receptors, and ligand gated calcium channels.

The Voltage-Gated Ion Channel (VIC) Superfamily

Proteins of the VIC family are ion-selective channel proteins found in a wide range of bacteria, archaea and eukaryotes Hille, B. (1992), Chapter 9: Structure of channel proteins; Chapter 20: Evolution and diversity. In: Ionic Channels of Excitable Membranes, 2nd Ed., Sinaur Assoc. Inc., Pubs., Sunderland, Massachusetts; Sigworth, F. J. (1993), Quart. Rev. Biophys. 27: 1-40; Salkoff, L. and T. Jegla (1995), Neuron 15: 489-492; Alexander, S. P. H. et al., (1997), Trends Pharmacol. Sci., Elsevier, pp. 76-84; Jan, L. Y. et al., (1997), Annu. Rev. Neurosci. 20: 91-123; Doyle, D. A, et al., (1998) Science 280: 69-77; Terlau, H. and W. Stühmer (1998), Naturwissenschaften 85: 437-444. They are often homo- or heterooligomeric structures with several dissimilar subunits (e.g., a1-a2-d-b Ca ²⁺ channels, ab₁b₂Na⁺ channels or (a)₄-b K⁺ channels), but the channel and the primary receptor is usually associated with the a (or al) subunit. Functionally characterized members are specific for K⁺, Na⁺ or Ca²⁺. The K⁺ channels usually consist of homotetrameric structures with each a-subunit possessing six transmembrane spanners (TMSs). The a1 and a subunits of the Ca²⁺ and Na⁺ channels, respectively, are about four times as large and possess 4 units, each with 6 TMSs separated by a hydrophilic loop, for a total of 24 TMSs. These large channel proteins form heterotetra-unit structures equivalent to the homotetrameric structures of most K⁺ channels. All four units of the Ca²⁺ and Na⁺ channels are homologous to the single unit in the homotetrameric K⁺ channels. Ion flux via the eukaryotic channels is generally controlled by the transmembrane electrical potential (hence the designation, voltage-sensitive) although some are controlled by ligand or receptor binding.

Several putative K+-selective channel proteins of the VIC family have been identified in prokaryotes. The structure of one of them, the KcsA K ⁺ channel of Streptomyces lividans, has been solved to 3.2 Å resolution. The protein possesses four identical subunits, each with two transmembrane helices, arranged in the shape of an inverted teepee or cone. The cone cradles the “selectivity filter” P domain in its outer end. The narrow selectivity filter is only 12 Å long, whereas the remainder of the channel is wider and lined with hydrophobic residues. A large water-filled cavity and helix dipoles stabilize K⁺ in the pore. The selectivity filter has two bound K⁺ ions about 7.5 Å apart from each other. Ion conduction is proposed to result from a balance of electrostatic attractive and repulsive forces.

In eukaryotes, each VIC family channel type has several subtypes based on pharmacological and electrophysiological data. Thus, there are five types of Ca ²⁺ channels (L, N, P, Q and T). There are at least ten types of K⁺ channels, each responding in different ways to different stimuli: voltage-sensitive [Ka, Kv, Kvr, Kvs and Ksr], Ca²⁺-sensitive [BK_Ca, IK_Caand SK_ca] and receptor-coupled [K_Mand K_ACh]. There are at least six types of Na⁺ channels (I, II, III, μ1, H1 and PN3). Tetrameric channels from both prokaryotic and eukaryotic organisms are known in which each a-subunit possesses 2 TMSs rather than 6, and these two TMSs are homologous to TMSs 5 and 6 of the six TMS unit found in the voltage-sensitive channel proteins. KcsA of S. lividans is an example of such a 2 TMS channel protein. These channels may include the K_Na(Na⁺-activated) and K_vo1(cell volume-sensitive) K⁺ channels, as well as distantly related channels such as the Tok1 K⁺ channel of yeast, the TWIK-1 inward rectifier K⁺ channel of the mouse and the TREK-1 K⁺ channel of the mouse. Because of insufficient sequence similarity with proteins of the VIC family, inward rectifier K⁺ IRK channels (ATP-regulated; G-protein-activated) which possess a P domain and two flanking TMSs are placed in a distinct family. However, substantial sequence similarity in the P region suggests that they are homologous. The b, g and d subunits of VIC family members, when present, frequently play regulatory roles in channel activation/deactivation.

Animal Inward Rectifier K ₊ Channel (IRK-C) Family

IRK channels possess the “minimal channel-forming structure” with only a P domain, characteristic of the channel proteins of the VIC family, and two flanking transmembrane spanners (Shuck, M. E., et al., (1994), J. Biol. Chem. 269: 24261-24270; Ashen, M. D., et al., (1 995), Am. J. Physiol. 268: H506-HS11; Salkoff, L. and T. Jegla (1995), Neuron 15: 489-492; Aguilar-Bryan, L., et al., (1998), Physiol. Rev. 78: 227-245; Ruknudin, A., et al., (1998), J. Biol. Chem. 273: 14165-14171). They may exist in the membrane as homo- or heterooligomers. They have a greater tendency to let K ⁺ flow into the cell than out. Voltage-dependence may be regulated by external K⁺, by internal Mg²⁺, by internal ATP and/or by G-proteins. The P domains of IRK channels exhibit limited sequence similarity to those of the VIC family, but this sequence similarity is insufficient to establish homology. Inward rectifiers play a role in setting cellular membrane potentials, and the closing of these channels upon depolarization permits the occurrence of long duration action potentials with a plateau phase. Inward rectifiers lack the intrinsic voltage sensing helices found in VIC family channels. In a few cases, those of Kir1.1a and Kir6.2, for example, direct interaction with a member of the ABC superfamily has been proposed to confer unique functional and regulatory properties to the heteromeric complex, including sensitivity to ATP. The SUR1 sulfonylurea receptor (spQ09428) is the ABC protein that regulates the Kir6.2 channel in response to ATP, and CFTR may regulate Kir1.1a. Mutations in SUR1 are the cause of familial persistent hyperinsulinemic hypoglycemia in infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion in the pancreas.

Erg Potassium Channels

The novel human protein, and encoding gene, provided by the present invention is a novel alternative splice form of human Erg ion channel proteins, which are inwardly rectifying potassium channels. Specifically, the protein of the present invention is an alternative splice form of the Erg3 protein provided in Genbank gi11121258. The protein of the present invention differs from the art-known protein of gi11121258 in exon 6 and in being of shorter overall length.

A family of genes that encode potassium ion channel proteins have been identified in and isolated from various organisms including C. elegans, Drosophila, mouse, rat, and humans. The members of the gene family are classified into subfamilies (eag, elk, and erg) on the basis of sequence similarity. The Eag family is named for the original isolate from Drosophila (ether-a go-go or eag). The Elk family includes genes that encode eag-like potassium ion channels. The Erg family includes eag-related genes.

Typically there is about 40-50% amino acid identity among proteins in the different subfamilies. Within a subfamily, the amino acid identity is about 60-70% even for proteins from different species. The human Erg ion-channel gene (Herg) corresponds to the LQT-2 genetic locus and maps to chromosome 7 q-35-36. Mutations in Herg can cause long-QT (LQT) syndrome, a relatively rare disorder that causes syncope and sudden death due to ventricular arrhythmia. The characteristic increased electrocardiographic Q-T interval evidences delayed repolarization of the cardiac action potential. At a molecular level, the delayed repolarization is linked with abnormal ion channel behavior. The Herg gene, in particular, is altered or defective in both acquired and inherited forms of LQT syndrome.

Herg ion channels are inwardly rectifying potassium channels. Herg channels have properties consistent with the gating properties of eag, and other, outwardly-rectifying, S4-containing potassium channels, but with the addition of an inactivation mechanism that attenuates potassium efflux during depolarization. It is thought that these properties of Herg channel function are critical to maintaining normal cardiac rhythmicity. The molecular mechanism by which Herg ion channels protect the heart against inappropriate rhythmicity is described in Smith, P. L., et al., “The Inward Rectification Mechanism of the HERG Cardiac Potassium Channel,” 379 Nature 33 (1996) and in Miller, C. “The Inconstancy of the Human Heart,” 379 Nature 767 (1996).

The Herg gene that encodes the Herg potassium ion channel subunits was described by Warmke, J. W. and B. Ganetzky, “A Family of Potassium Channel Genes Related to eag in Drosophila and Mammals,” 91 PNAS USA 3438-3442 (1994), incorporated herein by reference. The Herg DNA sequence is found at Genbank Accession Number U04270. A Drosophila erg gene was described by Titus, S. A., et al., “The Drosophila erg K.sup.+ Channel Polypeptide Is Encoded by the Seizure Locus,” 17 J. Neuroscience 875-881 (1997) and is reported at Genbank Accession Number U42204. A C. elegans erg gene is found at Accession Numbers U02425 and U02453 of the Genbank database. The two 10 kb pieces of genomic DNA therein disclosed encode amino acid sequences that align respectively to the N-and C-terminal halves of the Drosophila erg polypeptide.

Because of the critical role played by the Herg gene in a well known human disease, and its use in the development of pharmacological therapies, it is important to determine whether additional Herg-like genes exist in humans that could also play an important role in LQT syndrome or in other diseases characteristic of abnormal ion channel function. Herg channels are also an important target for the development of new pharmaceuticals. For a further review of Erg potassium channels, see Shi et al., J Neurosci 1997 Dec 15;17(24):9423-32.

Transporter proteins, particularly members of the Erg potassium channel subfamily, are a major target for drug action and development. Accordingly, it is valuable to the field of pharmaceutical development to identify and characterize previously unknown transport proteins. The present invention advances the state of the art by providing previously unidentified human transport proteins.

SUMMARY OF THE INVENTION

The present invention is based in part on the identification of amino acid sequences of a novel human Erg potassium channel alternative splice form, as well as allelic variants and other mammalian orthologs thereof. These unique amino acid sequences, and nucleic acid sequences that encode these amino acids, can be used as models for the development of human therapeutic targets, aid in the identification of therapeutic proteins, and serve as targets for the development of human therapeutic agents that modulate transporter activity in cells and tissues that express the transporter. Experimental data as provided in FIG. 1 indicates expression in humans in the testis and brain.

DESCRIPTION OF THE FIGURE SHEETS

FIG. 1 provides the nucleotide sequence of a cDNA molecule that encodes the transporter protein of the present invention. (SEQ ID NO:1) In addition structure and functional information is provided, such as ATG start, stop and tissue distribution, where available, that allows one to readily determine specific uses of inventions based on this molecular sequence. Experimental data as provided in FIG. 1 indicates expression in humans in the testis and brain. [0057]
FIG. 2 provides the predicted amino acid sequence of the transporter of the present invention. (SEQ ID NO:2) In addition structure and functional information such as protein family, function, and modification sites is provided where available, allowing one to readily determine specific uses of inventions based on this molecular sequence. [0058]
FIG. 3 provides genomic sequences that span the gene encoding the transporter protein of the present invention. (SEQ ID NO:3) In addition structure and functional information, such as intron/exon structure, promoter location, etc., is provided where available, allowing one to readily determine specific uses of inventions based on this molecular sequence. As illustrated in FIG. 3, SNPs were identified at 220 different nucleotide positions.[0059]

DETAILED DESCRIPTION OF THE INVENTION

General Description [0060]
The present invention is based on the sequencing of the human genome. During the sequencing and assembly of the human genome, analysis of the sequence information revealed previously unidentified fragments of the human genome that encode peptides that share structural and/or sequence homology to protein/peptide/domains identified and characterized within the art as being a transporter protein or part of a transporter protein and are related to the Erg potassium channel subfamily. Utilizing these sequences, additional genomic sequences were assembled and transcript and/or cDNA sequences were isolated and characterized. Based on this analysis, the present invention provides amino acid sequences of a novel human Erg potassium channel alternative splice form, nucleic acid sequences in the form of transcript sequences, cDNA sequences and/or genomic sequences that encode this novel alternative splice form, nucleic acid variation (allelic information), tissue distribution of expression, and information about the closest art known protein/peptide/domain that has structural or sequence homology to the transporter of the present invention. [0061]
In addition to being previously unknown, the peptides that are provided in the present invention are selected based on their ability to be used for the development of commercially important products and services. Specifically, the present peptides are selected based on homology and/or structural relatedness to known transporter proteins of the Erg potassium channel subfamily and the expression pattern observed. Experimental data as provided in FIG. 1 indicates expression in humans in the testis and brain. The art has clearly established the commercial importance of members of this family of proteins and proteins that have expression patterns similar to that of the present gene. Some of the more specific features of the peptides of the present invention, and the uses thereof, are described herein, particularly in the Background of the Invention and in the annotation provided in the Figures, and/or are known within the art for each of the known Erg potassium channel family or subfamily of transporter proteins. [0062]
Specific Embodiments [0063]
Peptide Molecules [0064]
The present invention provides nucleic acid sequences that encode protein molecules that have been identified as being members of the transporter family of proteins and are related to the Erg potassium channel subfamily (protein sequences are provided in FIG. 2, transcript/cDNA sequences are provided in FIG. 1 and genomic sequences are provided in FIG. 3). The peptide sequences provided in FIG. 2, as well as the obvious variants described herein, particularly allelic variants as identified herein and using the information in FIG. 3, will be referred herein as the transporter peptides of the present invention, transporter peptides, or peptides/proteins of the present invention. [0065]
The present invention provides isolated peptide and protein molecules that consist of, consist essentially of, or comprising the amino acid sequences of the transporter peptides disclosed in the FIG. 2, (encoded by the nucleic acid molecule shown in FIG. 1, transcript/cDNA or FIG. 3, genomic sequence), as well as all obvious variants of these peptides that are within the art to make and use. Some of these variants are described in detail below. [0066]
As used herein, a peptide is said to be “isolated” or “purified” when it is substantially free of cellular material or free of chemical precursors or other chemicals. The peptides of the present invention can be purified to homogeneity or other degrees of purity. The level of purification will be based on the intended use. The critical feature is that the preparation allows for the desired function of the peptide, even if in the presence of considerable amounts of other components (the features of an isolated nucleic acid molecule is discussed below). [0067]
In some uses, “substantially free of cellular material” includes preparations of the peptide having less than about 30% (by dry weight) other proteins (i.e., contaminating protein), less than about 20% other proteins, less than about 10% other proteins, or less than about 5% other proteins. When the peptide is recombinantly produced, it can also be substantially free of culture medium, i.e., culture medium represents less than about 20% of the volume of the protein preparation. [0068]
The language “substantially free of chemical precursors or other chemicals” includes preparations of the peptide in which it is separated from chemical precursors or other chemicals that are involved in its synthesis. In one embodiment, the language “substantially free of chemical precursors or other chemicals” includes preparations of the transporter peptide having less than about 30% (by dry weight) chemical precursors or other chemicals, less than about 20% chemical precursors or other chemicals, less than about 10% chemical precursors or other chemicals, or less than about 5% chemical precursors or other chemicals. [0069]
The isolated transporter peptide can be purified from cells that naturally express it, purified from cells that have been altered to express it (recombinant), or synthesized using known protein synthesis methods. Experimental data as provided in FIG. 1 indicates expression in humans in the testis and brain. For example, a nucleic acid molecule encoding the transporter peptide is cloned into an expression vector, the expression vector introduced into a host cell and the protein expressed in the host cell. The protein can then be isolated from the cells by an appropriate purification scheme using standard protein purification techniques. Many of these techniques are described in detail below. [0070]
Accordingly, the present invention provides proteins that consist of the amino acid sequences provided in FIG. 2 (SEQ ID NO:2), for example, proteins encoded by the transcript/cDNA nucleic acid sequences shown in FIG. 1 (SEQ ID NO:1) and the genomic sequences provided in FIG. 3 (SEQ ID NO:3). The amino acid sequence of such a protein is provided in FIG. 2. A protein consists of an amino acid sequence when the amino acid sequence is the final amino acid sequence of the protein. [0071]
The present invention further provides proteins that consist essentially of the amino acid sequences provided in FIG. 2 (SEQ ID NO:2), for example, proteins encoded by the transcript/cDNA nucleic acid sequences shown in FIG. 1 (SEQ ID NO:1) and the genomic sequences provided in FIG. 3 (SEQ ID NO:3). A protein consists essentially of an amino acid sequence when such an amino acid sequence is present with only a few additional amino acid residues, for example from about 1 to about 100 or so additional residues, typically from 1 to about 20 additional residues in the final protein. [0072]
The present invention further provides proteins that comprise the amino acid sequences provided in FIG. 2 (SEQ ID NO:2), for example, proteins encoded by the transcript/cDNA nucleic acid sequences shown in FIG. 1 (SEQ ID NO:1) and the genomic sequences provided in FIG. 3 (SEQ ID NO:3). A protein comprises an amino acid sequence when the amino acid sequence is at least part of the final amino acid sequence of the protein. In such a fashion, the protein can be only the peptide or have additional amino acid molecules, such as amino acid residues (contiguous encoded sequence) that are naturally associated with it or heterologous amino acid residues/peptide sequences. Such a protein can have a few additional amino acid residues or can comprise several hundred or more additional amino acids. The preferred classes of proteins that are comprised of the transporter peptides of the present invention are the naturally occurring mature proteins. A brief description of how various types of these proteins can be made/isolated is provided below. [0073]
The transporter peptides of the present invention can be attached to heterologous sequences to form chimeric or fusion proteins. Such chimeric and fusion proteins comprise a transporter peptide operatively linked to a heterologous protein having an amino acid sequence not substantially homologous to the transporter peptide. “Operatively linked” indicates that the transporter peptide and the heterologous protein are fused in-frame. The heterologous protein can be fused to the N-terminus or C-terminus of the transporter peptide. [0074]
In some uses, the fusion protein does not affect the activity of the transporter peptide per se. For example, the fusion protein can include, but is not limited to, enzymatic fusion proteins, for example beta-galactosidase fusions, yeast two-hybrid GAL fusions, poly-His fusions, MYC-tagged, HI-tagged and Ig fusions. Such fusion proteins, particularly poly-His fusions, can facilitate the purification of recombinant transporter peptide. In certain host cells (e.g., mammalian host cells), expression and/or secretion of a protein can be increased by using a heterologous signal sequence. [0075]
A chimeric or fusion protein can be produced by standard recombinant DNA techniques. For example, DNA fragments coding for the different protein sequences are ligated together in-frame in accordance with conventional techniques. In another embodiment, the fusion gene can be synthesized by conventional techniques including automated DNA synthesizers. Alternatively, PCR amplification of gene fragments can be carried out using anchor primers which give rise to complementary overhangs between two consecutive gene fragments which can subsequently be annealed and re-amplified to generate a chimeric gene sequence (see Ausubel et al., [0076] Current Protocols in Molecular Biology, 1992). Moreover, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST protein). A transporter peptide-encoding nucleic acid can be cloned into such an expression vector such that the fusion moiety is linked in-frame to the transporter peptide.
As mentioned above, the present invention also provides and enables obvious variants of the amino acid sequence of the proteins of the present invention, such as naturally occurring mature forms of the peptide, allelic/sequence variants of the peptides, non-naturally occurring recombinantly derived variants of the peptides, and orthologs and paralogs of the peptides. Such variants can readily be generated using art-known techniques in the fields of recombinant nucleic acid technology and protein biochemistry. It is understood, however, that variants exclude any amino acid sequences disclosed prior to the invention. [0077]
Such variants can readily be identified/made using molecular techniques and the sequence information disclosed herein. Further, such variants can readily be distinguished from other peptides based on sequence and/or structural homology to the transporter peptides of the present invention. The degree of homology/identity present will be based primarily on whether the peptide is a functional variant or non-functional variant, the amount of divergence present in the paralog family and the evolutionary distance between the orthologs. [0078]
To determine the percent identity of two amino acid sequences or two nucleic acid sequences, the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second amino acid or nucleic acid sequence for optimal alignment and non-homologous sequences can be disregarded for comparison purposes). In a preferred embodiment, at least 30%, 40%, 50%, 60%, 70%, 80%, or 90% or more of a reference sequence is aligned for comparison purposes. The amino acid residues or nucleotides at corresponding amino acid positions or nucleotide positions are then compared. When a position in the first sequence is occupied by the same amino acid residue or nucleotide as the corresponding position in the second sequence, then the molecules are identical at that position (as used herein amino acid or nucleic acid “identity” is equivalent to amino acid or nucleic acid “homology”). The percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, which need to be introduced for optimal alignment of the two sequences. [0079]
The comparison of sequences and determination of percent identity and similarity between two sequences can be accomplished using a mathematical algorithm. ([0080] Computational Molecular Biology, Lesk, A. M., ed., Oxford University Press, New York, 1988; Biocomputing: Informatics and Genome Projects, Smith, D. W., ed., Academic Press, New York, 1993; Computer Analysis of Sequence Data, Part 1, Griffin, A. M., and Griffin, H. G., eds., Humana Press, New Jersey, 1994; Sequence Analysis in Molecular Biology, von Heinje, G., Academic Press, 1987; and Sequence Analysis Primer, Gribskov, M. and Devereux, J., eds., M Stockton Press, New York, 1991). In a preferred embodiment, the percent identity between two amino acid sequences is determined using the Needleman and Wunsch (J. Mol. Biol. (48):444-453 (1970)) algorithm which has been incorporated into the GAP program in the GCG software package (available at http://www.gcg.com), using either a Blossom 62 matrix or a PAM250 matrix, and a gap weight of 16, 14, 12, 10, 8, 6, or 4 and a length weight of 1, 2, 3, 4, 5, or 6. In yet another preferred embodiment, the percent identity between two nucleotide sequences is determined using the GAP program in the GCG software package (Devereux, J., et al., Nucleic Acids Res. 12(1):387 (1984)) (available at http://www.gcg.com), using a NWSgapdna.CMP matrix and a gap weight of 40, 50, 60, 70, or 80 and a length weight of 1, 2, 3, 4, 5, or 6. In another embodiment, the percent identity between two amino acid or nucleotide sequences is determined using the algorithm of E. Myers and W. Miller (CABIOS, 4:11-17 (1989)) which has been incorporated into the ALIGN program (version 2.0), using a PAM120 weight residue table, a gap length penalty of 12 and a gap penalty of 4.
The nucleic acid and protein sequences of the present invention can further be used as a “query sequence” to perform a search against sequence databases to, for example, identify other family members or related sequences. Such searches can be performed using the NBLAST and XBLAST programs (version 2.0) of Altschul, et al. ([0081] J. Mol. Biol. 215:403-10 (1990)). BLAST nucleotide searches can be performed with the NBLAST program, score=100, wordlength=12 to obtain nucleotide sequences homologous to the nucleic acid molecules of the invention. BLAST protein searches can be performed with the XBLAST program, score=50, wordlength=3 to obtain amino acid sequences homologous to the proteins of the invention. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized as described in Altschul et al. (Nucleic Acids Res. 25(17):3389-3402 (1997)). When utilizing BLAST and gapped BLAST programs, the default parameters of the respective programs (e.g., XBLAST and NBLAST) can be used.
Full-length pre-processed forms, as well as mature processed forms, of proteins that comprise one of the peptides of the present invention can readily be identified as having complete sequence identity to one of the transporter peptides of the present invention as well as being encoded by the same genetic locus as the transporter peptide provided herein. The gene encoding the novel transporter protein of the present invention is located on a genome component that has been mapped to human chromosome 2 (as indicated in FIG. 3), which is supported by multiple lines of evidence, such as STS and BAC map data. [0082]
Allelic variants of a transporter peptide can readily be identified as being a human protein having a high degree (significant) of sequence homology/identity to at least a portion of the transporter peptide as well as being encoded by the same genetic locus as the transporter peptide provided herein. Genetic locus can readily be determined based on the genomic information provided in FIG. 3, such as the genomic sequence mapped to the reference human. The gene encoding the novel transporter protein of the present invention is located on a genome component that has been mapped to human chromosome 2 (as indicated in FIG. 3), which is supported by multiple lines of evidence, such as STS and BAC map data. As used herein, two proteins (or a region of the proteins) have significant homology when the amino acid sequences are typically at least about 70-80%, 80-90%, and more typically at least about 90-95% or more homologous. A significantly homologous amino acid sequence, according to the present invention, will be encoded by a nucleic acid sequence that will hybridize to a transporter peptide encoding nucleic acid molecule under stringent conditions as more fully described below. [0083]
FIG. 3 provides information on SNPs that have been found in the gene encoding the transporter protein of the present invention. SNPs were identified at 220 different nucleotide positions. Some of these SNPs may affect control/regulatory elements. [0084]
Paralogs of a transporter peptide can readily be identified as having some degree of significant sequence homology/identity to at least a portion of the transporter peptide, as being encoded by a gene from humans, and as having similar activity or function. Two proteins will typically be considered paralogs when the amino acid sequences are typically at least about 60% or greater, and more typically at least about 70% or greater homology through a given region or domain. Such paralogs will be encoded by a nucleic acid sequence that will hybridize to a transporter peptide encoding nucleic acid molecule under moderate to stringent conditions as more fully described below. [0085]
Orthologs of a transporter peptide can readily be identified as having some degree of significant sequence homology/identity to at least a portion of the transporter peptide as well as being encoded by a gene from another organism. Preferred orthologs will be isolated from mammals, preferably primates, for the development of human therapeutic targets and agents. Such orthologs will be encoded by a nucleic acid sequence that will hybridize to a transporter peptide encoding nucleic acid molecule under moderate to stringent conditions, as more fully described below, depending on the degree of relatedness of the two organisms yielding the proteins. [0086]
Non-naturally occurring variants of the transporter peptides of the present invention can readily be generated using recombinant techniques. Such variants include, but are not limited to deletions, additions and substitutions in the amino acid sequence of the transporter peptide. For example, one class of substitutions are conserved amino acid substitution. Such substitutions are those that substitute a given amino acid in a transporter peptide by another amino acid of like characteristics. Typically seen as conservative substitutions are the replacements, one for another, among the aliphatic amino acids Ala, Val, Leu, and Ile; interchange of the hydroxyl residues Ser and Thr; exchange of the acidic residues Asp and Glu; substitution between the amide residues Asn and Gln; exchange of the basic residues Lys and Arg; and replacements among the aromatic residues Phe and Tyr. Guidance concerning which amino acid changes are likely to be phenotypically silent are found in Bowie et al., [0087] Science 247:1306-1310 (1990).
Variant transporter peptides can be fully functional or can lack function in one or more activities, e.g. ability to bind ligand, ability to transport ligand, ability to mediate signaling, etc. Fully functional variants typically contain only conservative variation or variation in non-critical residues or in non-critical regions. FIG. 2 provides the result of protein analysis and can be used to identify critical domains/regions. Functional variants can also contain substitution of similar amino acids that result in no change or an insignificant change in function. Alternatively, such substitutions may positively or negatively affect function to some degree. [0088]
Non-functional variants typically contain one or more non-conservative amino acid substitutions, deletions, insertions, inversions, or truncation or a substitution, insertion, inversion, or deletion in a critical residue or critical region. [0089]
Amino acids that are essential for function can be identified by methods known in the art, such as site-directed mutagenesis or alanine-scanning mutagenesis (Cunningham et al., [0090] Science 244:1081-1085 (1989)), particularly using the results provided in FIG. 2. The latter procedure introduces single alanine mutations at every residue in the molecule. The resulting mutant molecules are then tested for biological activity such as transporter activity or in assays such as an in vitro proliferative activity. Sites that are critical for binding partner/substrate binding can also be determined by structural analysis such as crystallization, nuclear magnetic resonance or photoaffinity labeling (Smith et al., J. Mol. Biol. 224:899-904 (1992); de Vos et al. Science 255:306-312 (1992)).
The present invention further provides fragments of the transporter peptides, in addition to proteins and peptides that comprise and consist of such fragments, particularly those comprising the residues identified in FIG. 2. The fragments to which the invention pertains, however, are not to be construed as encompassing fragments that may be disclosed publicly prior to the present invention. [0091]
As used herein, a fragment comprises at least 8, 10, 12, 14, 16, or more contiguous amino acid residues from a transporter peptide. Such fragments can be chosen based on the ability to retain one or more of the biological activities of the transporter peptide or could be chosen for the ability to perform a function, e.g. bind a substrate or act as an immunogen. Particularly important fragments are biologically active fragments, peptides that are, for example, about 8 or more amino acids in length. Such fragments will typically comprise a domain or motif of the transporter peptide, e.g., active site, a transmembrane domain or a substrate-binding domain. Further, possible fragments include, but are not limited to, domain or motif containing fragments, soluble peptide fragments, and fragments containing immunogenic structures. Predicted domains and functional sites are readily identifiable by computer programs well known and readily available to those of skill in the art (e.g., PROSITE analysis). The results of one such analysis are provided in FIG. 2. [0092]
Polypeptides often contain amino acids other than the 20 amino acids commonly referred to as the 20 naturally occurring amino acids. Further, many amino acids, including the terminal amino acids, may be modified by natural processes, such as processing and other post-translational modifications, or by chemical modification techniques well known in the art. Common modifications that occur naturally in transporter peptides are described in basic texts, detailed monographs, and the research literature, and they are well known to those of skill in the art (some of these features are identified in FIG. 2). [0093]
Known modifications include, but are not limited to, acetylation, acylation, ADP-ribosylation, amidation, covalent attachment of flavin, covalent attachment of a heme moiety, covalent attachment of a nucleotide or nucleotide derivative, covalent attachment of a lipid or lipid derivative, covalent attachment of phosphotidylinositol, cross-linking, cyclization, disulfide bond formation, demethylation, formation of covalent crosslinks, formation of cystine, formation of pyroglutamate, formylation, gamma carboxylation, glycosylation, GPI anchor formation, hydroxylation, iodination, methylation, myristoylation, oxidation, proteolytic processing, phosphorylation, prenylation, racemization, selenoylation, sulfation, transfer-RNA mediated addition of amino acids to proteins such as arginylation, and ubiquitination. [0094]
Such modifications are well known to those of skill in the art and have been described in great detail in the scientific literature. Several particularly common modifications, glycosylation, lipid attachment, sulfation, gamma-carboxylation of glutamic acid residues, hydroxylation and ADP-ribosylation, for instance, are described in most basic texts, such as [0095] Proteins—Structure and Molecular Properties, 2nd Ed., T. E. Creighton, W. H. Freeman and Company, New York (1993). Many detailed reviews are available on this subject, such as by Wold, F., Posttranslational Covalent Modification of Proteins, B. C. Johnson, Ed., Academic Press, New York 1-12 (1983); Seifter et al (Meth. Enzymol. 182: 626-646 (1990)) and Rattan et al. (Ann. N.Y. Acad. Sci. 663:48-62 (1992)).
Accordingly, the transporter peptides of the present invention also encompass derivatives or analogs in which a substituted amino acid residue is not one encoded by the genetic code, in which a substituent group is included, in which the mature transporter peptide is fused with another compound, such as a compound to increase the half-life of the transporter peptide (for example, polyethylene glycol), or in which the additional amino acids are fused to the mature transporter peptide, such as a leader or secretory sequence or a sequence for purification of the mature transporter peptide or a pro-protein sequence. [0096]
Protein/Peptide Uses [0097]
The proteins of the present invention can be used in substantial and specific assays related to the functional information provided in the Figures; to raise antibodies or to elicit another immune response; as a reagent (including the labeled reagent) in assays designed to quantitatively determine levels of the protein (or its binding partner or ligand) in biological fluids; and as markers for tissues in which the corresponding protein is preferentially expressed (either constitutively or at a particular stage of tissue differentiation or development or in a disease state). Where the protein binds or potentially binds to another protein or ligand (such as, for example, in a transporter-effector protein interaction or transporter-ligand interaction), the protein can be used to identify the binding partner/ligand so as to develop a system to identify inhibitors of the binding interaction. Any or all of these uses are capable of being developed into reagent grade or kit format for commercialization as commercial products. [0098]
Methods for performing the uses listed above are well known to those skilled in the art. References disclosing such methods include “Molecular Cloning: A Laboratory Manual”, 2d ed., Cold Spring Harbor Laboratory Press, Sambrook, J., E. F. Fritsch and T. Maniatis eds., 1989, and “Methods in Enzymology: Guide to Molecular Cloning Techniques”, Academic Press, Berger, S. L. and A. R. Kimmel eds., 1987. [0099]
The potential uses of the peptides of the present invention are based primarily on the source of the protein as well as the class/action of the protein. For example, transporters isolated from humans and their human/mammalian orthologs serve as targets for identifying agents for use in mammalian therapeutic applications, e.g. a human drug, particularly in modulating a biological or pathological response in a cell or tissue that expresses the transporter. Experimental data as provided in FIG. 1 indicates that the transporter proteins of the present invention are expressed in humans in the testis (indicated by virtual northern blot analysis) and brain (indicated by PCR-based tissue screening panels). A large percentage of pharmaceutical agents are being developed that modulate the activity of transporter proteins, particularly members of the Erg potassium channel subfamily (see Background of the Invention). The structural and functional information provided in the Background and Figures provide specific and substantial uses for the molecules of the present invention, particularly in combination with the expression information provided in FIG. 1. Experimental data as provided in FIG. 1 indicates expression in humans in the testis and brain. Such uses can readily be determined using the information provided herein, that known in the art and routine experimentation. [0100]
The proteins of the present invention (including variants and fragments that may have been disclosed prior to the present invention) are useful for biological assays related to transporters that are related to members of the Erg potassium channel subfamily. Such assays involve any of the known transporter functions or activities or properties useful for diagnosis and treatment of transporter-related conditions that are specific for the subfamily of transporters that the one of the present invention belongs to, particularly in cells and tissues that express the transporter. Experimental data as provided in FIG. 1 indicates that the transporter proteins of the present invention are expressed in humans in the testis (indicated by virtual northern blot analysis) and brain (indicated by PCR-based tissue screening panels). The proteins of the present invention are also useful in drug screening assays, in cell-based or cell-free systems ((Hodgson, Bio/technology, September 1992, 10(9);973-80). Cell-based systems can be native, i.e., cells that normally express the transporter, as a biopsy or expanded in cell culture. Experimental data as provided in FIG. 1 indicates expression in humans in the testis and brain. In an alternate embodiment, cell-based assays involve recombinant host cells expressing the transporter protein. [0101]
The polypeptides can be used to identify compounds that modulate transporter activity of the protein in its natural state or an altered form that causes a specific disease or pathology associated with the transporter. Both the transporters of the present invention and appropriate variants and fragments can be used in high-throughput screens to assay candidate compounds for the ability to bind to the transporter. These compounds can be further screened against a functional transporter to determine the effect of the compound on the transporter activity. Further, these compounds can be tested in animal or invertebrate systems to determine activity/effectiveness. Compounds can be identified that activate (agonist) or inactivate (antagonist) the transporter to a desired degree. [0102]
Further, the proteins of the present invention can be used to screen a compound for the ability to stimulate or inhibit interaction between the transporter protein and a molecule that normally interacts with the transporter protein, e.g. a substrate or a component of the signal pathway that the transporter protein normally interacts (for example, another transporter). Such assays typically include the steps of combining the transporter protein with a candidate compound under conditions that allow the transporter protein, or fragment, to interact with the target molecule, and to detect the formation of a complex between the protein and the target or to detect the biochemical consequence of the interaction with the transporter protein and the target, such as any of the associated effects of signal transduction such as changes in membrane potential, protein phosphorylation, cAMP turnover, and adenylate cyclase activation, etc. [0103]
Candidate compounds include, for example, 1) peptides such as soluble peptides, including Ig-tailed fusion peptides and members of random peptide libraries (see, e.g., Lam et al., [0104] Nature 354:82-84 (1991); Houghten et al., Nature 354:84-86 (1991)) and combinatorial chemistry-derived molecular libraries made of D- and/or L-configuration amino acids; 2) phosphopeptides (e.g., members of random and partially degenerate, directed phosphopeptide libraries, see, e.g., Songyang et al., Cell 72:767-778 (1993)); 3) antibodies (e.g., polyclonal, monoclonal, humanized, anti-idiotypic, chimeric, and single chain antibodies as well as Fab, F(ab′)₂, Fab expression library fragments, and epitope-binding fragments of antibodies); and 4) small organic and inorganic molecules (e.g., molecules obtained from combinatorial and natural product libraries).
One candidate compound is a soluble fragment of the receptor that competes for ligand binding. Other candidate compounds include mutant transporters or appropriate fragments containing mutations that affect transporter function and thus compete for ligand. Accordingly, a fragment that competes for ligand, for example with a higher affinity, or a fragment that binds ligand but does not allow release, is encompassed by the invention. [0105]
The invention further includes other end point assays to identify compounds that modulate (stimulate or inhibit) transporter activity. The assays typically involve an assay of events in the signal transduction pathway that indicate transporter activity. Thus, the transport of a ligand, change in cell membrane potential, activation of a protein, a change in the expression of genes that are up- or down-regulated in response to the transporter protein dependent signal cascade can be assayed. [0106]
Any of the biological or biochemical functions mediated by the transporter can be used as an endpoint assay. These include all of the biochemical or biochemical/biological events described herein, in the references cited herein, incorporated by reference for these endpoint assay targets, and other functions known to those of ordinary skill in the art or that can be readily identified using the information provided in the Figures, particularly FIG. 2. Specifically, a biological function of a cell or tissues that expresses the transporter can be assayed. Experimental data as provided in FIG. 1 indicates that the transporter proteins of the present invention are expressed in humans in the testis (indicated by virtual northern blot analysis) and brain (indicated by PCR-based tissue screening panels). [0107]
Binding and/or activating compounds can also be screened by using chimeric transporter proteins in which the amino terminal extracellular domain, or parts thereof, the entire transmembrane domain or subregions, such as any of the seven transmembrane segments or any of the intracellular or extracellular loops and the carboxy terminal intracellular domain, or parts thereof, can be replaced by heterologous domains or subregions. For example, a ligand-binding region can be used that interacts with a different ligand then that which is recognized by the native transporter. Accordingly, a different set of signal transduction components is available as an end-point assay for activation. This allows for assays to be performed in other than the specific host cell from which the transporter is derived. [0108]
The proteins of the present invention are also useful in competition binding assays in methods designed to discover compounds that interact with the transporter (e.g. binding partners and/or ligands). Thus, a compound is exposed to a transporter polypeptide under conditions that allow the compound to bind or to otherwise interact with the polypeptide. Soluble transporter polypeptide is also added to the mixture. If the test compound interacts with the soluble transporter polypeptide, it decreases the amount of complex formed or activity from the transporter target. This type of assay is particularly useful in cases in which compounds are sought that interact with specific regions of the transporter. Thus, the soluble polypeptide that competes with the target transporter region is designed to contain peptide sequences corresponding to the region of interest. [0109]
To perform cell free drug screening assays, it is sometimes desirable to immobilize either the transporter protein, or fragment, or its target molecule to facilitate separation of complexes from uncomplexed forms of one or both of the proteins, as well as to accommodate automation of the assay. [0110]
Techniques for immobilizing proteins on matrices can be used in the drug screening assays. In one embodiment, a fusion protein can be provided which adds a domain that allows the protein to be bound to a matrix. For example, glutathione-S-transferase fusion proteins can be adsorbed onto glutathione sepharose beads (Sigma Chemical, St. Louis, Mo.) or glutathione derivatized microtitre plates, which are then combined with the cell lysates (e.g., [0111] ³⁵S-labeled) and the candidate compound, and the mixture incubated under conditions conducive to complex formation (e.g., at physiological conditions for salt and pH). Following incubation, the beads are washed to remove any unbound label, and the matrix immobilized and radiolabel determined directly, or in the supernatant after the complexes are dissociated. Alternatively, the complexes can be dissociated from the matrix, separated by SDS-PAGE, and the level of transporter-binding protein found in the bead fraction quantitated from the gel using standard electrophoretic techniques. For example, either the polypeptide or its target molecule can be immobilized utilizing conjugation of biotin and streptavidin using techniques well known in the art. Alternatively, antibodies reactive with the protein but which do not interfere with binding of the protein to its target molecule can be derivatized to the wells of the plate, and the protein trapped in the wells by antibody conjugation. Preparations of a transporter-binding protein and a candidate compound are incubated in the transporter protein-presenting wells and the amount of complex trapped in the well can be quantitated. Methods for detecting such complexes, in addition to those described above for the GST-immobilized complexes, include immunodetection of complexes using antibodies reactive with the transporter protein target molecule, or which are reactive with transporter protein and compete with the target molecule, as well as enzyme-linked assays which rely on detecting an enzymatic activity associated with the target molecule.
Agents that modulate one of the transporters of the present invention can be identified using one or more of the above assays, alone or in combination. It is generally preferable to use a cell-based or cell free system first and then confirm activity in an animal or other model system. Such model systems are well known in the art and can readily be employed in this context. [0112]
Modulators of transporter protein activity identified according to these drug screening assays can be used to treat a subject with a disorder mediated by the transporter pathway, by treating cells or tissues that express the transporter. Experimental data as provided in FIG. 1 indicates expression in humans in the testis and brain. These methods of treatment include the steps of administering a modulator of transporter activity in a pharmaceutical composition to a subject in need of such treatment, the modulator being identified as described herein. [0113]
In yet another aspect of the invention, the transporter proteins can be used as “bait proteins” in a two-hybrid assay or three-hybrid assay (see, e.g., U.S. Pat. No. 5,283,317; Zervos et al. (1993) [0114] Cell 72:223-232; Madura et al. (1993) J. Biol. Chem. 268:12046-12054; Bartel et al. (1993) Biotechniques 14:920-924; Iwabuchi et al. (1993) Oncogene 8:1693-1696; and Brent WO94/10300), to identify other proteins, which bind to or interact with the transporter and are involved in transporter activity. Such transporter-binding proteins are also likely to be involved in the propagation of signals by the transporter proteins or transporter targets as, for example, downstream elements of a transporter-mediated signaling pathway. Alternatively, such transporter-binding proteins are likely to be transporter inhibitors.
The two-hybrid system is based on the modular nature of most transcription factors, which consist of separable DNA-binding and activation domains. Briefly, the assay utilizes two different DNA constructs. In one construct, the gene that codes for a transporter protein is fused to a gene encoding the DNA binding domain of a known transcription factor (e.g., GAL-4). In the other construct, a DNA sequence, from a library of DNA sequences, that encodes an unidentified protein (“prey” or “sample”) is fused to a gene that codes for the activation domain of the known transcription factor. If the “bait” and the “prey” proteins are able to interact, in vivo, forming a transporter-dependent complex, the DNA-binding and activation domains of the transcription factor are brought into close proximity. This proximity allows transcription of a reporter gene (e.g., LacZ) which is operably linked to a transcriptional regulatory site responsive to the transcription factor. Expression of the reporter gene can be detected and cell colonies containing the functional transcription factor can be isolated and used to obtain the cloned gene which encodes the protein which interacts with the transporter protein. [0115]
This invention further pertains to novel agents identified by the above-described screening assays. Accordingly, it is within the scope of this invention to further use an agent identified as described herein in an appropriate animal model. For example, an agent identified as described herein (e.g., a transporter-modulating agent, an antisense transporter nucleic acid molecule, a transporter-specific antibody, or a transporter-binding partner) can be used in an animal or other model to determine the efficacy, toxicity, or side effects of treatment with such an agent. Alternatively, an agent identified as described herein can be used in an animal or other model to determine the mechanism of action of such an agent. Furthermore, this invention pertains to uses of novel agents identified by the above-described screening assays for treatments as described herein. [0116]
The transporter proteins of the present invention are also useful to provide a target for diagnosing a disease or predisposition to disease mediated by the peptide. Accordingly, the invention provides methods for detecting the presence, or levels of, the protein (or encoding mRNA) in a cell, tissue, or organism. Experimental data as provided in FIG. 1 indicates expression in humans in the testis and brain. The method involves contacting a biological sample with a compound capable of interacting with the transporter protein such that the interaction can be detected. Such an assay can be provided in a single detection format or a multi-detection format such as an antibody chip array. [0117]
One agent for detecting a protein in a sample is an antibody capable of selectively binding to protein. A biological sample includes tissues, cells and biological fluids isolated from a subject, as well as tissues, cells and fluids present within a subject. [0118]
The peptides of the present invention also provide targets for diagnosing active protein activity, disease, or predisposition to disease, in a patient having a variant peptide, particularly activities and conditions that are known for other members of the family of proteins to which the present one belongs. Thus, the peptide can be isolated from a biological sample and assayed for the presence of a genetic mutation that results in aberrant peptide. This includes amino acid substitution, deletion, insertion, rearrangement, (as the result of aberrant splicing events), and inappropriate post-translational modification. Analytic methods include altered electrophoretic mobility, altered tryptic peptide digest, altered transporter activity in cell-based or cell-free assay, alteration in ligand or antibody-binding pattern, altered isoelectric point, direct amino acid sequencing, and any other of the known assay techniques useful for detecting mutations in a protein. Such an assay can be provided in a single detection format or a multi-detection format such as an antibody chip array. [0119]
In vitro techniques for detection of peptide include enzyme linked immunosorbent assays (ELISAs), Western blots, immunoprecipitations and immunofluorescence using a detection reagent, such as an antibody or protein binding agent. Alternatively, the peptide can be detected in vivo in a subject by introducing into the subject a labeled anti-peptide antibody or other types of detection agent. For example, the antibody can be labeled with a radioactive marker whose presence and location in a subject can be detected by standard imaging techniques. Particularly useful are methods that detect the allelic variant of a peptide expressed in a subject and methods which detect fragments of a peptide in a sample. [0120]
The peptides are also useful in pharmacogenomic analysis. Pharmacogenomics deal with clinically significant hereditary variations in the response to drugs due to altered drug disposition and abnormal action in affected persons. See, e.g., Eichelbaum, M. ([0121] Clin. Exp. Pharmacol. Physiol. 23(10-11):983-985 (1996)), and Linder, M. W. (Clin. Chem. 43(2):254-266 (1997)). The clinical outcomes of these variations result in severe toxicity of therapeutic drugs in certain individuals or therapeutic failure of drugs in certain individuals as a result of individual variation in metabolism. Thus, the genotype of the individual can determine the way a therapeutic compound acts on the body or the way the body metabolizes the compound. Further, the activity of drug metabolizing enzymes effects both the intensity and duration of drug action. Thus, the pharmacogenomics of the individual permit the selection of effective compounds and effective dosages of such compounds for prophylactic or therapeutic treatment based on the individual's genotype. The discovery of genetic polymorphisms in some drug metabolizing enzymes has explained why some patients do not obtain the expected drug effects, show an exaggerated drug effect, or experience serious toxicity from standard drug dosages. Polymorphisms can be expressed in the phenotype of the extensive metabolizer and the phenotype of the poor metabolizer. Accordingly, genetic polymorphism may lead to allelic protein variants of the transporter protein in which one or more of the transporter functions in one population is different from those in another population. The peptides thus allow a target to ascertain a genetic predisposition that can affect treatment modality. Thus, in a ligand-based treatment, polymorphism may give rise to amino terminal extracellular domains and/or other ligand-binding regions that are more or less active in ligand binding, and transporter activation. Accordingly, ligand dosage would necessarily be modified to maximize the therapeutic effect within a given population containing a polymorphism. As an alternative to genotyping, specific polymorphic peptides could be identified.
The peptides are also useful for treating a disorder characterized by an absence of, inappropriate, or unwanted expression of the protein. Experimental data as provided in FIG. 1 indicates expression in humans in the testis and brain. Accordingly, methods for treatment include the use of the transporter protein or fragments. [0122]
Antibodies [0123]
The invention also provides antibodies that selectively bind to one of the peptides of the present invention, a protein comprising such a peptide, as well as variants and fragments thereof. As used herein, an antibody selectively binds a target peptide when it binds the target peptide and does not significantly bind to unrelated proteins. An antibody is still considered to selectively bind a peptide even if it also binds to other proteins that are not substantially homologous with the target peptide so long as such proteins share homology with a fragment or domain of the peptide target of the antibody. In this case, it would be understood that antibody binding to the peptide is still selective despite some degree of cross-reactivity. [0124]
As used herein, an antibody is defined in terms consistent with that recognized within the art: they are multi-subunit proteins produced by a mammalian organism in response to an antigen challenge. The antibodies of the present invention include polyclonal antibodies and monoclonal antibodies, as well as fragments of such antibodies, including, but not limited to, Fab or F(ab′)[0125] ₂, and Fv fragments.
Many methods are known for generating and/or identifying antibodies to a given target peptide. Several such methods are described by Harlow, Antibodies, Cold Spring Harbor Press, (1989). [0126]
In general, to generate antibodies, an isolated peptide is used as an immunogen and is administered to a mammalian organism, such as a rat, rabbit or mouse. The full-length protein, an antigenic peptide fragment or a fusion protein can be used. Particularly important fragments are those covering functional domains, such as the domains identified in FIG. 2, and domain of sequence homology or divergence amongst the family, such as those that can readily be identified using protein alignment methods and as presented in the Figures. [0127]
Antibodies are preferably prepared from regions or discrete fragments of the transporter proteins. Antibodies can be prepared from any region of the peptide as described herein. However, preferred regions will include those involved in function/activity and/or transporter/binding partner interaction. FIG. 2 can be used to identify particularly important regions while sequence alignment can be used to identify conserved and unique sequence fragments. [0128]
An antigenic fragment will typically comprise at least 8 contiguous amino acid residues. The antigenic peptide can comprise, however, at least 10, 12, 14, 16 or more amino acid residues. Such fragments can be selected on a physical property, such as fragments correspond to regions that are located on the surface of the protein, e.g., hydrophilic regions or can be selected based on sequence uniqueness (see FIG. 2). [0129]
Detection on an antibody of the present invention can be facilitated by coupling (i.e., physically linking) the antibody to a detectable substance. Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, β-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include [0130] ¹²⁵I, ¹³¹I, ³⁵S or ³H.
Antibody Uses [0131]
The antibodies can be used to isolate one of the proteins of the present invention by standard techniques, such as affinity chromatography or immunoprecipitation. The antibodies can facilitate the purification of the natural protein from cells and recombinantly produced protein expressed in host cells. In addition, such antibodies are useful to detect the presence of one of the proteins of the present invention in cells or tissues to determine the pattern of expression of the protein among various tissues in an organism and over the course of normal development. Experimental data as provided in FIG. 1 indicates that the transporter proteins of the present invention are expressed in humans in the testis (indicated by virtual northern blot analysis) and brain (indicated by PCR-based tissue screening panels). Further, such antibodies can be used to detect protein in situ, in vitro, or in a cell lysate or supernatant in order to evaluate the abundance and pattern of expression. Also, such antibodies can be used to assess abnormal tissue distribution or abnormal expression during development or progression of a biological condition. Antibody detection of circulating fragments of the full length protein can be used to identify turnover. [0132]
Further, the antibodies can be used to assess expression in disease states such as in active stages of the disease or in an individual with a predisposition toward disease related to the protein's function. When a disorder is caused by an inappropriate tissue distribution, developmental expression, level of expression of the protein, or expressed/processed form, the antibody can be prepared against the normal protein. Experimental data as provided in FIG. 1 indicates expression in humans in the testis and brain. If a disorder is characterized by a specific mutation in the protein, antibodies specific for this mutant protein can be used to assay for the presence of the specific mutant protein. [0133]
The antibodies can also be used to assess normal and aberrant subcellular localization of cells in the various tissues in an organism. Experimental data as provided in FIG. 1 indicates expression in humans in the testis and brain. The diagnostic uses can be applied, not only in genetic testing, but also in monitoring a treatment modality. Accordingly, where treatment is ultimately aimed at correcting expression level or the presence of aberrant sequence and aberrant tissue distribution or developmental expression, antibodies directed against the protein or relevant fragments can be used to monitor therapeutic efficacy. [0134]
Additionally, antibodies are useful in pharmacogenomic analysis. Thus, antibodies prepared against polymorphic proteins can be used to identify individuals that require modified treatment modalities. The antibodies are also useful as diagnostic tools as an immunological marker for aberrant protein analyzed by electrophoretic mobility, isoelectric point, tryptic peptide digest, and other physical assays known to those in the art. [0135]
The antibodies are also useful for tissue typing. Experimental data as provided in FIG. 1 indicates expression in humans in the testis and brain. Thus, where a specific protein has been correlated with expression in a specific tissue, antibodies that are specific for this protein can be used to identify a tissue type. [0136]
The antibodies are also useful for inhibiting protein function, for example, blocking the binding of the transporter peptide to a binding partner such as a ligand or protein binding partner. These uses can also be applied in a therapeutic context in which treatment involves inhibiting the protein's function. An antibody can be used, for example, to block binding, thus modulating (agonizing or antagonizing) the peptides activity. Antibodies can be prepared against specific fragments containing sites required for function or against intact protein that is associated with a cell or cell membrane. See FIG. 2 for structural information relating to the proteins of the present invention. [0137]
The invention also encompasses kits for using antibodies to detect the presence of a protein in a biological sample. The kit can comprise antibodies such as a labeled or labelable antibody and a compound or agent for detecting protein in a biological sample; means for determining the amount of protein in the sample; means for comparing the amount of protein in the sample with a standard; and instructions for use. Such a kit can be supplied to detect a single protein or epitope or can be configured to detect one of a multitude of epitopes, such as in an antibody detection array. Arrays are described in detail below for nucleic acid arrays and similar methods have been developed for antibody arrays. [0138]
Nucleic Acid Molecules [0139]
The present invention further provides isolated nucleic acid molecules that encode a transporter peptide or protein of the present invention (cDNA, transcript and genomic sequence). Such nucleic acid molecules will consist of, consist essentially of, or comprise a nucleotide sequence that encodes one of the transporter peptides of the present invention, an allelic variant thereof, or an ortholog or paralog thereof [0140]
As used herein, an “isolated” nucleic acid molecule is one that is separated from other nucleic acid present in the natural source of the nucleic acid. Preferably, an “isolated” nucleic acid is free of sequences that naturally flank the nucleic acid (i.e., sequences located at the 5′ and 3′ ends of the nucleic acid) in the genomic DNA of the organism from which the nucleic acid is derived. However, there can be some flanking nucleotide sequences, for example up to about 5 KB, 4 KB, 3 KB, 2 KB, or 1 KB or less, particularly contiguous peptide encoding sequences and peptide encoding sequences within the same gene but separated by introns in the genomic sequence. The important point is that the nucleic acid is isolated from remote and unimportant flanking sequences such that it can be subjected to the specific manipulations described herein such as recombinant expression, preparation of probes and primers, and other uses specific to the nucleic acid sequences. [0141]
Moreover, an “isolated” nucleic acid molecule, such as a transcript/cDNA molecule, can be substantially free of other cellular material, or culture medium when produced by recombinant techniques, or chemical precursors or other chemicals when chemically synthesized. However, the nucleic acid molecule can be fused to other coding or regulatory sequences and still be considered isolated. [0142]
For example, recombinant DNA molecules contained in a vector are considered isolated. Further examples of isolated DNA molecules include recombinant DNA molecules maintained in heterologous host cells or purified (partially or substantially) DNA molecules in solution. Isolated RNA molecules include in vivo or in vitro RNA transcripts of the isolated DNA molecules of the present invention. Isolated nucleic acid molecules according to the present invention further include such molecules produced synthetically. [0143]
Accordingly, the present invention provides nucleic acid molecules that consist of the nucleotide sequence shown in FIG. 1 or [0144] 3 (SEQ ID NO:1, transcript sequence and SEQ ID NO:3, genomic sequence), or any nucleic acid molecule that encodes the protein provided in FIG. 2, SEQ ID NO:2. A nucleic acid molecule consists of a nucleotide sequence when the nucleotide sequence is the complete nucleotide sequence of the nucleic acid molecule.
The present invention further provides nucleic acid molecules that consist essentially of the nucleotide sequence shown in FIG. 1 or [0145] 3 (SEQ ID NO:1, transcript sequence and SEQ ID NO:3, genomic sequence), or any nucleic acid molecule that encodes the protein provided in FIG. 2, SEQ ID NO:2. A nucleic acid molecule consists essentially of a nucleotide sequence when such a nucleotide sequence is present with only a few additional nucleic acid residues in the final nucleic acid molecule.
The present invention further provides nucleic acid molecules that comprise the nucleotide sequences shown in FIG. 1 or [0146] 3 (SEQ ID NO:1, transcript sequence and SEQ ID NO:3, genomic sequence), or any nucleic acid molecule that encodes the protein provided in FIG. 2, SEQ ID NO:2. A nucleic acid molecule comprises a nucleotide sequence when the nucleotide sequence is at least part of the final nucleotide sequence of the nucleic acid molecule. In such a fashion, the nucleic acid molecule can be only the nucleotide sequence or have additional nucleic acid residues, such as nucleic acid residues that are naturally associated with it or heterologous nucleotide sequences. Such a nucleic acid molecule can have a few additional nucleotides or can comprise several hundred or more additional nucleotides. A brief description of how various types of these nucleic acid molecules can be readily made/isolated is provided below.
In FIGS. 1 and 3, both coding and non-coding sequences are provided. Because of the source of the present invention, humans genomic sequence (FIG. 3) and cDNA/transcript sequences (FIG. 1), the nucleic acid molecules in the Figures will contain genomic intronic sequences, 5′ and 3′ non-coding sequences, gene regulatory regions and non-coding intergenic sequences. In general such sequence features are either noted in FIGS. 1 and 3 or can readily be identified using computational tools known in the art. As discussed below, some of the non-coding regions, particularly gene regulatory elements such as promoters, are useful for a variety of purposes, e.g. control of heterologous gene expression, target for identifying gene activity modulating compounds, and are particularly claimed as fragments of the genomic sequence provided herein. [0147]
The isolated nucleic acid molecules can encode the mature protein plus additional amino or carboxyl-terminal amino acids, or amino acids interior to the mature peptide (when the mature form has more than one peptide chain, for instance). Such sequences may play a role in processing of a protein from precursor to a mature form, facilitate protein trafficking, prolong or shorten protein half-life or facilitate manipulation of a protein for assay or production, among other things. As generally is the case in situ, the additional amino acids may be processed away from the mature protein by cellular enzymes. [0148]
As mentioned above, the isolated nucleic acid molecules include, but are not limited to, the sequence encoding the transporter peptide alone, the sequence encoding the mature peptide and additional coding sequences, such as a leader or secretory sequence (e.g., a pre-pro or pro-protein sequence), the sequence encoding the mature peptide, with or without the additional coding sequences, plus additional non-coding sequences, for example introns and non-coding 5′ and 3′ sequences such as transcribed but non-translated sequences that play a role in transcription, mRNA processing (including splicing and polyadenylation signals), ribosome binding and stability of mRNA. In addition, the nucleic acid molecule may be fused to a marker sequence encoding, for example, a peptide that facilitates purification. [0149]
Isolated nucleic acid molecules can be in the form of RNA, such as mRNA, or in the form DNA, including cDNA and genomic DNA obtained by cloning or produced by chemical synthetic techniques or by a combination thereof. The nucleic acid, especially DNA, can be double-stranded or single-stranded. Single-stranded nucleic acid can be the coding strand (sense strand) or the non-coding strand (anti-sense strand). [0150]
The invention further provides nucleic acid molecules that encode fragments of the peptides of the present invention as well as nucleic acid molecules that encode obvious variants of the transporter proteins of the present invention that are described above. Such nucleic acid molecules may be naturally occurring, such as allelic variants (same locus), paralogs (different locus), and orthologs (different organism), or may be constructed by recombinant DNA methods or by chemical synthesis. Such non-naturally occurring variants may be made by mutagenesis techniques, including those applied to nucleic acid molecules, cells, or organisms. Accordingly, as discussed above, the variants can contain nucleotide substitutions, deletions, inversions and insertions. Variation can occur in either or both the coding and non-coding regions. The variations can produce both conservative and non-conservative amino acid substitutions. [0151]
The present invention further provides non-coding fragments of the nucleic acid molecules provided in FIGS. 1 and 3. Preferred non-coding fragments include, but are not limited to, promoter sequences, enhancer sequences, gene modulating sequences and gene termination sequences. Such fragments are useful in controlling heterologous gene expression and in developing screens to identify gene-modulating agents. A promoter can readily be identified as being 5′ to the ATG start site in the genomic sequence provided in FIG. 3. [0152]
A fragment comprises a contiguous nucleotide sequence greater than 12 or more nucleotides. Further, a fragment could at least 30, 40, 50, 100, 250 or 500 nucleotides in length. The length of the fragment will be based on its intended use. For example, the fragment can encode epitope bearing regions of the peptide, or can be useful as DNA probes and primers. Such fragments can be isolated using the known nucleotide sequence to synthesize an oligonucleotide probe. A labeled probe can then be used to screen a cDNA library, genomic DNA library, or mRNA to isolate nucleic acid corresponding to the coding region. Further, primers can be used in PCR reactions to clone specific regions of gene. [0153]
A probe/primer typically comprises substantially a purified oligonucleotide or oligonucleotide pair. The oligonucleotide typically comprises a region of nucleotide sequence that hybridizes under stringent conditions to at least about 12, 20, 25, 40, 50 or more consecutive nucleotides. [0154]
Orthologs, homologs, and allelic variants can be identified using methods well known in the art. As described in the Peptide Section, these variants comprise a nucleotide sequence encoding a peptide that is typically 60-70%, 70-80%, 80-90%, and more typically at least about 90-95% or more homologous to the nucleotide sequence shown in the Figure sheets or a fragment of this sequence. Such nucleic acid molecules can readily be identified as being able to hybridize under moderate to stringent conditions, to the nucleotide sequence shown in the Figure sheets or a fragment of the sequence. Allelic variants can readily be determined by genetic locus of the encoding gene. The gene encoding the novel transporter protein of the present invention is located on a genome component that has been mapped to human chromosome 2 (as indicated in FIG. 3), which is supported by multiple lines of evidence, such as STS and BAC map data. [0155]
FIG. 3 provides information on SNPs that have been found in the gene encoding the transporter protein of the present invention. SNPs were identified at 220 different nucleotide positions. Some of these SNPs may affect control/regulatory elements. [0156]
As used herein, the term “hybridizes under stringent conditions” is intended to describe conditions for hybridization and washing under which nucleotide sequences encoding a peptide at least 60-70% homologous to each other typically remain hybridized to each other. The conditions can be such that sequences at least about 60%, at least about 70%, or at least about 80% or more homologous to each other typically remain hybridized to each other. Such stringent conditions are known to those skilled in the art and can be found in [0157] Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. (1989), 6.3.1-6.3.6. One example of stringent hybridization conditions are hybridization in 6× sodium chloride/sodium citrate (SSC) at about 45C, followed by one or more washes in 0.2× SSC, 0.1% SDS at 50-65C. Examples of moderate to low stringency hybridization conditions are well known in the art.
Nucleic Acid Molecule Uses [0158]
The nucleic acid molecules of the present invention are useful for probes, primers, chemical intermediates, and in biological assays. The nucleic acid molecules are useful as a hybridization probe for messenger RNA, transcript/cDNA and genomic DNA to isolate full-length cDNA and genomic clones encoding the peptide described in FIG. 2 and to isolate cDNA and genomic clones that correspond to variants (alleles, orthologs, etc.) producing the same or related peptides shown in FIG. 2. As illustrated in FIG. 3, SNPs were identified at 220 different nucleotide positions. [0159]
The probe can correspond to any sequence along the entire length of the nucleic acid molecules provided in the Figures. Accordingly, it could be derived from 5′ noncoding regions, the coding region, and 3′ noncoding regions. However, as discussed, fragments are not to be construed as encompassing fragments disclosed prior to the present invention. [0160]
The nucleic acid molecules are also useful as primers for PCR to amplify any given region of a nucleic acid molecule and are useful to synthesize antisense molecules of desired length and sequence. [0161]
The nucleic acid molecules are also useful for constructing recombinant vectors. Such vectors include expression vectors that express a portion of, or all of, the peptide sequences. Vectors also include insertion vectors, used to integrate into another nucleic acid molecule sequence, such as into the cellular genome, to alter in situ expression of a gene and/or gene product. For example, an endogenous coding sequence can be replaced via homologous recombination with all or part of the coding region containing one or more specifically introduced mutations. [0162]
The nucleic acid molecules are also useful for expressing antigenic portions of the proteins. [0163]
The nucleic acid molecules are also useful as probes for determining the chromosomal positions of the nucleic acid molecules by means of in situ hybridization methods. The gene encoding the novel transporter protein of the present invention is located on a genome component that has been mapped to human chromosome 2 (as indicated in FIG. 3), which is supported by multiple lines of evidence, such as STS and BAC map data. [0164]
The nucleic acid molecules are also useful in making vectors containing the gene regulatory regions of the nucleic acid molecules of the present invention. [0165]
The nucleic acid molecules are also useful for designing ribozymes corresponding to all, or a part, of the mRNA produced from the nucleic acid molecules described herein. [0166]
The nucleic acid molecules are also useful for making vectors that express part, or all, of the peptides. [0167]
The nucleic acid molecules are also useful for constructing host cells expressing a part, or all, of the nucleic acid molecules and peptides. [0168]
The nucleic acid molecules are also useful for constructing transgenic animals expressing all, or a part, of the nucleic acid molecules and peptides. [0169]
The nucleic acid molecules are also useful as hybridization probes for determining the presence, level, form and distribution of nucleic acid expression. Experimental data as provided in FIG. 1 indicates that the transporter proteins of the present invention are expressed in humans in the testis (indicated by virtual northern blot analysis) and brain (indicated by PCR-based tissue screening panels). [0170]
Accordingly, the probes can be used to detect the presence of, or to determine levels of, a specific nucleic acid molecule in cells, tissues, and in organisms. The nucleic acid whose level is determined can be DNA or RNA. Accordingly, probes corresponding to the peptides described herein can be used to assess expression and/or gene copy number in a given cell, tissue, or organism. These uses are relevant for diagnosis of disorders involving an increase or decrease in transporter protein expression relative to normal results. [0171]
In vitro techniques for detection of mRNA include Northern hybridizations and in situ hybridizations. In vitro techniques for detecting DNA include Southern hybridizations and in situ hybridization. [0172]
Probes can be used as a part of a diagnostic test kit for identifying cells or tissues that express a transporter protein, such as by measuring a level of a transporter-encoding nucleic acid in a sample of cells from a subject e.g., mRNA or genomic DNA, or determining if a transporter gene has been mutated. Experimental data as provided in FIG. 1 indicates that the transporter proteins of the present invention are expressed in humans in the testis (indicated by virtual northern blot analysis) and brain (indicated by PCR-based tissue screening panels). [0173]
Nucleic acid expression assays are useful for drug screening to identify compounds that modulate transporter nucleic acid expression. [0174]
The invention thus provides a method for identifying a compound that can be used to treat a disorder associated with nucleic acid expression of the transporter gene, particularly biological and pathological processes that are mediated by the transporter in cells and tissues that express it. Experimental data as provided in FIG. 1 indicates expression in humans in the testis and brain. The method typically includes assaying the ability of the compound to modulate the expression of the transporter nucleic acid and thus identifying a compound that can be used to treat a disorder characterized by undesired transporter nucleic acid expression. The assays can be performed in cell-based and cell-free systems. Cell-based assays include cells naturally expressing the transporter nucleic acid or recombinant cells genetically engineered to express specific nucleic acid sequences. [0175]
The assay for transporter nucleic acid expression can involve direct assay of nucleic acid levels, such as mRNA levels, or on collateral compounds involved in the signal pathway. Further, the expression of genes that are up- or down-regulated in response to the transporter protein signal pathway can also be assayed. In this embodiment the regulatory regions of these genes can be operably linked to a reporter gene such as luciferase. [0176]
Thus, modulators of transporter gene expression can be identified in a method wherein a cell is contacted with a candidate compound and the expression of mRNA determined. The level of expression of transporter mRNA in the presence of the candidate compound is compared to the level of expression of transporter mRNA in the absence of the candidate compound. The candidate compound can then be identified as a modulator of nucleic acid expression based on this comparison and be used, for example to treat a disorder characterized by aberrant nucleic acid expression. When expression of mRNA is statistically significantly greater in the presence of the candidate compound than in its absence, the candidate compound is identified as a stimulator of nucleic acid expression. When nucleic acid expression is statistically significantly less in the presence of the candidate compound than in its absence, the candidate compound is identified as an inhibitor of nucleic acid expression. [0177]
The invention further provides methods of treatment, with the nucleic acid as a target, using a compound identified through drug screening as a gene modulator to modulate transporter nucleic acid expression in cells and tissues that express the transporter. Experimental data as provided in FIG. 1 indicates that the transporter proteins of the present invention are expressed in humans in the testis (indicated by virtual northern blot analysis) and brain (indicated by PCR-based tissue screening panels). Modulation includes both up-regulation (i.e. activation or agonization) or down-regulation (suppression or antagonization) or nucleic acid expression. [0178]
Alternatively, a modulator for transporter nucleic acid expression can be a small molecule or drug identified using the screening assays described herein as long as the drug or small molecule inhibits the transporter nucleic acid expression in the cells and tissues that express the protein. Experimental data as provided in FIG. 1 indicates expression in humans in the testis and brain. [0179]
The nucleic acid molecules are also useful for monitoring the effectiveness of modulating compounds on the expression or activity of the transporter gene in clinical trials or in a treatment regimen. Thus, the gene expression pattern can serve as a barometer for the continuing effectiveness of treatment with the compound, particularly with compounds to which a patient can develop resistance. The gene expression pattern can also serve as a marker indicative of a physiological response of the affected cells to the compound. Accordingly, such monitoring would allow either increased administration of the compound or the administration of alternative compounds to which the patient has not become resistant. Similarly, if the level of nucleic acid expression falls below a desirable level, administration of the compound could be commensurately decreased. [0180]
The nucleic acid molecules are also useful in diagnostic assays for qualitative changes in transporter nucleic acid expression, and particularly in qualitative changes that lead to pathology. The nucleic acid molecules can be used to detect mutations in transporter genes and gene expression products such as mRNA. The nucleic acid molecules can be used as hybridization probes to detect naturally occurring genetic mutations in the transporter gene and thereby to determine whether a subject with the mutation is at risk for a disorder caused by the mutation. Mutations include deletion, addition, or substitution of one or more nucleotides in the gene, chromosomal rearrangement, such as inversion or transposition, modification of genomic DNA, such as aberrant methylation patterns or changes in gene copy number, such as amplification. Detection of a mutated form of the transporter gene associated with a dysfunction provides a diagnostic tool for an active disease or susceptibility to disease when the disease results from overexpression, underexpression, or altered expression of a transporter protein. [0181]
Individuals carrying mutations in the transporter gene can be detected at the nucleic acid level by a variety of techniques. FIG. 3 provides information on SNPs that have been found in the gene encoding the transporter protein of the present invention. SNPs were identified at 220 different nucleotide positions. Some of these SNPs may affect control/regulatory elements. The gene encoding the novel transporter protein of the present invention is located on a genome component that has been mapped to human chromosome 2 (as indicated in FIG. 3), which is supported by multiple lines of evidence, such as STS and BAC map data. Genomic DNA can be analyzed directly or can be amplified by using PCR prior to analysis. RNA or cDNA can be used in the same way. In some uses, detection of the mutation involves the use of a probe/primer in a polymerase chain reaction (PCR) (see, e.g. U.S. Pat. Nos. 4,683,195 and 4,683,202), such as anchor PCR or RACE PCR, or, alternatively, in a ligation chain reaction (LCR) (see, e.g., Landegran et al., [0182] Science 241:1077-1080 (1988); and Nakazawa et al., PNAS 91:360-364 (1 994)), the latter of which can be particularly useful for detecting point mutations in the gene (see Abravaya et al., Nucleic Acids Res. 23:675-682 (1995)). This method can include the steps of collecting a sample of cells from a patient, isolating nucleic acid (e.g., genomic, mRNA or both) from the cells of the sample, contacting the nucleic acid sample with one or more primers which specifically hybridize to a gene under conditions such that hybridization and amplification of the gene (if present) occurs, and detecting the presence or absence of an amplification product, or detecting the size of the amplification product and comparing the length to a control sample. Deletions and insertions can be detected by a change in size of the amplified product compared to the normal genotype. Point mutations can be identified by hybridizing amplified DNA to normal RNA or antisense DNA sequences.
Alternatively, mutations in a transporter gene can be directly identified, for example, by alterations in restriction enzyme digestion patterns determined by gel electrophoresis. [0183]
Further, sequence-specific ribozymes (U.S. Pat. No. 5,498,531) can be used to score for the presence of specific mutations by development or loss of a ribozyme cleavage site. Perfectly matched sequences can be distinguished from mismatched sequences by nuclease cleavage digestion assays or by differences in melting temperature. [0184]
Sequence changes at specific locations can also be assessed by nuclease protection assays such as RNase and S1 protection or the chemical cleavage method. Furthermore, sequence differences between a mutant transporter gene and a wild-type gene can be determined by direct DNA sequencing. A variety of automated sequencing procedures can be utilized when performing the diagnostic assays (Naeve, C. W., (1995) [0185] Biotechniques 19:448), including sequencing by mass spectrometry (see, e.g., PCT International Publication No. WO 94/16101; Cohen et al., Adv. Chromatogr. 36:127-162 (1996); and Griffin et al., Appl. Biochem. Biotechnol. 38:147-159 (1993)).
Other methods for detecting mutations in the gene include methods in which protection from cleavage agents is used to detect mismatched bases in RNA/RNA or RNA/DNA duplexes (Myers et al., [0186] Science 230:1242 (1985)); Cotton et al., PNAS 85:4397 (1988); Saleeba et al., Meth. Enzymol. 217:286-295 (1992)), electrophoretic mobility of mutant and wild type nucleic acid is compared (Orita et al., PNAS 86:2766 (1989); Cotton et al., Mutat. Res. 285:125-144 (1993); and Hayashi et al., Genet. Anal. Tech. Appl. 9:73-79 (1992)), and movement of mutant or wild-type fragments in polyacrylamide gels containing a gradient of denaturant is assayed using denaturing gradient gel electrophoresis (Myers et al., Nature 313:495 (1985)). Examples of other techniques for detecting point mutations include selective oligonucleotide hybridization, selective amplification, and selective primer extension.
The nucleic acid molecules are also useful for testing an individual for a genotype that while not necessarily causing the disease, nevertheless affects the treatment modality. Thus, the nucleic acid molecules can be used to study the relationship between an individual's genotype and the individual's response to a compound used for treatment (pharmacogenomic relationship). Accordingly, the nucleic acid molecules described herein can be used to assess the mutation content of the transporter gene in an individual in order to select an appropriate compound or dosage regimen for treatment. FIG. 3 provides information on SNPs that have been found in the gene encoding the transporter protein of the present invention. SNPs were identified at 220 different nucleotide positions. Some of these SNPs may affect control/regulatory elements. [0187]
Thus nucleic acid molecules displaying genetic variations that affect treatment provide a diagnostic target that can be used to tailor treatment in an individual. Accordingly, the production of recombinant cells and animals containing these polymorphisms allow effective clinical design of treatment compounds and dosage regimens. [0188]
The nucleic acid molecules are thus useful as antisense constructs to control transporter gene expression in cells, tissues, and organisms. A DNA antisense nucleic acid molecule is designed to be complementary to a region of the gene involved in transcription, preventing transcription and hence production of transporter protein. An antisense RNA or DNA nucleic acid molecule would hybridize to the mRNA and thus block translation of mRNA into transporter protein. [0189]
Alternatively, a class of antisense molecules can be used to inactivate mRNA in order to decrease expression of transporter nucleic acid. Accordingly, these molecules can treat a disorder characterized by abnormal or undesired transporter nucleic acid expression. This technique involves cleavage by means of ribozymes containing nucleotide sequences complementary to one or more regions in the mRNA that attenuate the ability of the mRNA to be translated. Possible regions include coding regions and particularly coding regions corresponding to the catalytic and other functional activities of the transporter protein, such as ligand binding. [0190]
The nucleic acid molecules also provide vectors for gene therapy in patients containing cells that are aberrant in transporter gene expression. Thus, recombinant cells, which include the patient's cells that have been engineered ex vivo and returned to the patient, are introduced into an individual where the cells produce the desired transporter protein to treat the individual. [0191]
The invention also encompasses kits for detecting the presence of a transporter nucleic acid in a biological sample. Experimental data as provided in FIG. 1 indicates that the transporter proteins of the present invention are expressed in humans in the testis (indicated by virtual northern blot analysis) and brain (indicated by PCR-based tissue screening panels). For example, the kit can comprise reagents such as a labeled or labelable nucleic acid or agent capable of detecting transporter nucleic acid in a biological sample; means for determining the amount of transporter nucleic acid in the sample; and means for comparing the amount of transporter nucleic acid in the sample with a standard. The compound or agent can be packaged in a suitable container. The kit can further comprise instructions for using the kit to detect transporter protein mRNA or DNA. [0192]
Nucleic Acid Arrays [0193]
The present invention further provides nucleic acid detection kits, such as arrays or microarrays of nucleic acid molecules that are based on the sequence information provided in FIGS. 1 and 3 (SEQ ID NOS:1 and 3). [0194]
As used herein “Arrays” or “Microarrays” refers to an array of distinct polynucleotides or oligonucleotides synthesized on a substrate, such as paper, nylon or other type of membrane, filter, chip, glass slide, or any other suitable solid support. In one embodiment, the microarray is prepared and used according to the methods described in U.S. Pat. No. 5,837,832, Chee et al., PCT application WO95111995 (Chee et al.), Lockhart, D. J. et al. (1996; Nat. Biotech. 14: 1675-1680) and Schena, M. et al. (1996; Proc. Natl. Acad. Sci. 93: 10614-10619), all of which are incorporated herein in their entirety by reference. In other embodiments, such arrays are produced by the methods described by Brown et al., U.S. Pat. No. 5,807,522. [0195]
The microarray or detection kit is preferably composed of a large number of unique, single-stranded nucleic acid sequences, usually either synthetic antisense oligonucleotides or fragments of cDNAs, fixed to a solid support. The oligonucleotides are preferably about 6-60 nucleotides in length, more preferably 15-30 nucleotides in length, and most preferably about 20-25 nucleotides in length. For a certain type of microarray or detection kit, it may be preferable to use oligonucleotides that are only 7-20 nucleotides in length. The microarray or detection kit may contain oligonucleotides that cover the known 5′, or 3′, sequence, sequential oligonucleotides that cover the full length sequence; or unique oligonucleotides selected from particular areas along the length of the sequence. Polynucleotides used in the microarray or detection kit may be oligonucleotides that are specific to a gene or genes of interest. [0196]
In order to produce oligonucleotides to a known sequence for a microarray or detection kit, the gene(s) of interest (or an ORF identified from the contigs of the present invention) is typically examined using a computer algorithm which starts at the 5′ or at the 3′ end of the nucleotide sequence. Typical algorithms will then identify oligomers of defined length that are unique to the gene, have a GC content within a range suitable for hybridization, and lack predicted secondary structure that may interfere with hybridization. In certain situations it may be appropriate to use pairs of oligonucleotides on a microarray or detection kit. The “pairs” will be identical, except for one nucleotide that preferably is located in the center of the sequence. The second oligonucleotide in the pair (mismatched by one) serves as a control. The number of oligonucleotide pairs may range from two to one million. The oligomers are synthesized at designated areas on a substrate using a light-directed chemical process. The substrate may be paper, nylon or other type of membrane, filter, chip, glass slide or any other suitable solid support. [0197]
In another aspect, an oligonucleotide may be synthesized on the surface of the substrate by using a chemical coupling procedure and an ink jet application apparatus, as described in PCT application WO95/251116 (Baldeschweiler et al.) which is incorporated herein in its entirety by reference. In another aspect, a “gridded” array analogous to a dot (or slot) blot may be used to arrange and link cDNA fragments or oligonucleotides to the surface of a substrate using a vacuum system, thermal, UV, mechanical or chemical bonding procedures. An array, such as those described above, may be produced by hand or by using available devices (slot blot or dot blot apparatus), materials (any suitable solid support), and machines (including robotic instruments), and may contain 8, 24, 96, 384, 1536, 6144 or more oligonucleotides, or any other number between two and one million which lends itself to the efficient use of commercially available instrumentation. [0198]
In order to conduct sample analysis using a microarray or detection kit, the RNA or DNA from a biological sample is made into hybridization probes. The mRNA is isolated, and cDNA is produced and used as a template to make antisense RNA (aRNA). The aRNA is amplified in the presence of fluorescent nucleotides, and labeled probes are incubated with the microarray or detection kit so that the probe sequences hybridize to complementary oligonucleotides of the microarray or detection kit. Incubation conditions are adjusted so that hybridization occurs with precise complementary matches or with various degrees of less complementarity. After removal of nonhybridized probes, a scanner is used to determine the levels and patterns of fluorescence. The scanned images are examined to determine degree of complementarity and the relative abundance of each oligonucleotide sequence on the microarray or detection kit. The biological samples may be obtained from any bodily fluids (such as blood, urine, saliva, phlegm, gastric juices, etc.), cultured cells, biopsies, or other tissue preparations. A detection system may be used to measure the absence, presence, and amount of hybridization for all of the distinct sequences simultaneously. This data may be used for large-scale correlation studies on the sequences, expression patterns, mutations, variants, or polymorphisms among samples. [0199]
Using such arrays, the present invention provides methods to identify the expression of the transporter proteins/peptides of the present invention. In detail, such methods comprise incubating a test sample with one or more nucleic acid molecules and assaying for binding of the nucleic acid molecule with components within the test sample. Such assays will typically involve arrays comprising many genes, at least one of which is a gene of the present invention and or alleles of the transporter gene of the present invention. FIG. 3 provides information on SNPs that have been found in the gene encoding the transporter protein of the present invention. SNPs were identified at 220 different nucleotide positions. Some of these SNPs may affect control/regulatory elements. [0200]
Conditions for incubating a nucleic acid molecule with a test sample vary. Incubation conditions depend on the format employed in the assay, the detection methods employed, and the type and nature of the nucleic acid molecule used in the assay. One skilled in the art will recognize that any one of the commonly available hybridization, amplification or array assay formats can readily be adapted to employ the novel fragments of the Human genome disclosed herein. Examples of such assays can be found in Chard, T, [0201] An Introduction to Radioimmunoassay and Related Techniques, Elsevier Science Publishers, Amsterdam, The Netherlands (1986); Bullock, G. R. et al., Techniques in Immunocytochemistry, Academic Press, Orlando, Fla. Vol. 1 (1 982), Vol. 2 (1983), Vol. 3 (1985); Tijssen, P., Practice and Theory of Enzyme Immunoassays: Laboratory Techniques in Biochemistry and Molecular Biology, Elsevier Science Publishers, Amsterdam, The Netherlands (1985).
The test samples of the present invention include cells, protein or membrane extracts of cells. The test sample used in the above-described method will vary based on the assay format, nature of the detection method and the tissues, cells or extracts used as the sample to be assayed. Methods for preparing nucleic acid extracts or of cells are well known in the art and can be readily be adapted in order to obtain a sample that is compatible with the system utilized. [0202]
In another embodiment of the present invention, kits are provided which contain the necessary reagents to carry out the assays of the present invention. [0203]
Specifically, the invention provides a compartmentalized kit to receive, in close confinement, one or more containers which comprises: (a) a first container comprising one of the nucleic acid molecules that can bind to a fragment of the Human genome disclosed herein; and (b) one or more other containers comprising one or more of the following: wash reagents, reagents capable of detecting presence of a bound nucleic acid. [0204]
In detail, a compartmentalized kit includes any kit in which reagents are contained in separate containers. Such containers include small glass containers, plastic containers, strips of plastic, glass or paper, or arraying material such as silica. Such containers allows one to efficiently transfer reagents from one compartment to another compartment such that the samples and reagents are not cross-contaminated, and the agents or solutions of each container can be added in a quantitative fashion from one compartment to another. Such containers will include a container which will accept the test sample, a container which contains the nucleic acid probe, containers which contain wash reagents (such as phosphate buffered saline, Tris-buffers, etc.), and containers which contain the reagents used to detect the bound probe. One skilled in the art will readily recognize that the previously unidentified transporter gene of the present invention can be routinely identified using the sequence information disclosed herein can be readily incorporated into one of the established kit formats which are well known in the art, particularly expression arrays. [0205]
Vectors/Host Cells [0206]
The invention also provides vectors containing the nucleic acid molecules described herein. The term “vector” refers to a vehicle, preferably a nucleic acid molecule, which can transport the nucleic acid molecules. When the vector is a nucleic acid molecule, the nucleic acid molecules are covalently linked to the vector nucleic acid. With this aspect of the invention, the vector includes a plasmid, single or double stranded phage, a single or double stranded RNA or DNA viral vector, or artificial chromosome, such as a BAC, PAC, YAC, OR MAC. [0207]
A vector can be maintained in the host cell as an extrachromosomal element where it replicates and produces additional copies of the nucleic acid molecules. Alternatively, the vector may integrate into the host cell genome and produce additional copies of the nucleic acid molecules when the host cell replicates. [0208]
The invention provides vectors for the maintenance (cloning vectors) or vectors for expression (expression vectors) of the nucleic acid molecules. The vectors can function in procaryotic or eukaryotic cells or in both (shuttle vectors). [0209]
Expression vectors contain cis-acting regulatory regions that are operably linked in the vector to the nucleic acid molecules such that transcription of the nucleic acid molecules is allowed in a host cell. The nucleic acid molecules can be introduced into the host cell with a separate nucleic acid molecule capable of affecting transcription. Thus, the second nucleic acid molecule may provide a trans-acting factor interacting with the cis-regulatory control region to allow transcription of the nucleic acid molecules from the vector. Alternatively, a trans-acting factor may be supplied by the host cell. Finally, a trans-acting factor can be produced from the vector itself. It is understood, however, that in some embodiments, transcription and/or translation of the nucleic acid molecules can occur in a cell-free system. [0210]
The regulatory sequence to which the nucleic acid molecules described herein can be operably linked include promoters for directing mRNA transcription. These include, but are not limited to, the left promoter from bacteriophage λ, the lac, TRP, and TAC promoters from [0211] E. coli, the early and late promoters from SV40, the CMV immediate early promoter, the adenovirus early and late promoters, and retrovirus long-terminal repeats.
In addition to control regions that promote transcription, expression vectors may also include regions that modulate transcription, such as repressor binding sites and enhancers. Examples include the SV40 enhancer, the cytomegalovirus immediate early enhancer, polyoma enhancer, adenovirus enhancers, and retrovirus LTR enhancers. [0212]
In addition to containing sites for transcription initiation and control, expression vectors can also contain sequences necessary for transcription termination and, in the transcribed region a ribosome binding site for translation. Other regulatory control elements for expression include initiation and termination codons as well as polyadenylation signals. The person of ordinary skill in the art would be aware of the numerous regulatory sequences that are useful in expression vectors. Such regulatory sequences are described, for example, in Sambrook et al., [0213] Molecular Cloning: A Laboratory Manual. 2nd. ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., (1989).
A variety of expression vectors can be used to express a nucleic acid molecule. Such vectors include chromosomal, episomal, and virus-derived vectors, for example vectors derived from bacterial plasmids, from bacteriophage, from yeast episomes, from yeast chromosomal elements, including yeast artificial chromosomes, from viruses such as baculoviruses, papovaviruses such as SV40, Vaccinia viruses, adenoviruses, poxviruses, pseudorabies viruses, and retroviruses. Vectors may also be derived from combinations of these sources such as those derived from plasmid and bacteriophage genetic elements, e.g. cosmids and phagemids. Appropriate cloning and expression vectors for prokaryotic and eukaryotic hosts are described in Sambrook et al., [0214] Molecular Cloning: A Laboratory Manual. 2nd. ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., (1989).
The regulatory sequence may provide constitutive expression in one or more host cells (i.e. tissue specific) or may provide for inducible expression in one or more cell types such as by temperature, nutrient additive, or exogenous factor such as a hormone or other ligand. A variety of vectors providing for constitutive and inducible expression in prokaryotic and eukaryotic hosts are well known to those of ordinary skill in the art. [0215]
The nucleic acid molecules can be inserted into the vector nucleic acid by well-known methodology. Generally, the DNA sequence that will ultimately be expressed is joined to an expression vector by cleaving the DNA sequence and the expression vector with one or more restriction enzymes and then ligating the fragments together. Procedures for restriction enzyme digestion and ligation are well known to those of ordinary skill in the art. [0216]
The vector containing the appropriate nucleic acid molecule can be introduced into an appropriate host cell for propagation or expression using well-known techniques. Bacterial cells include, but are not limited to, [0217] E. coli, Streptomyces, and Salmonella typhimurium. Eukaryotic cells include, but are not limited to, yeast, insect cells such as Drosophila, animal cells such as COS and CHO cells, and plant cells.
As described herein, it may be desirable to express the peptide as a fusion protein. Accordingly, the invention provides fusion vectors that allow for the production of the peptides. Fusion vectors can increase the expression of a recombinant protein, increase the solubility of the recombinant protein, and aid in the purification of the protein by acting for example as a ligand for affinity purification. A proteolytic cleavage site may be introduced at the junction of the fusion moiety so that the desired peptide can ultimately be separated from the fusion moiety. Proteolytic enzymes include, but are not limited to, factor Xa, thrombin, and enterotransporter. Typical fusion expression vectors include pGEX (Smith et al., [0218] Gene 67:31-40 (1988)), pMAL (New England Biolabs, Beverly, Mass.) and pRIT5 (Pharmacia, Piscataway, N.J.) which fuse glutathione S-transferase (GST), maltose E binding protein, or protein A, respectively, to the target recombinant protein. Examples of suitable inducible non-fusion E. coli expression vectors include pTrc (Amann et al., Gene 69:301-315 (1988)) and pET 11d (Studier et al., Gene Expression Technology: Methods in Enzymology 185:60-89 (1990)).
Recombinant protein expression can be maximized in host bacteria by providing a genetic background wherein the host cell has an impaired capacity to proteolytically cleave the recombinant protein. (Gottesman, S., [0219] Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990)119-128). Alternatively, the sequence of the nucleic acid molecule of interest can be altered to provide preferential codon usage for a specific host cell, for example E. coli. (Wada et al., Nucleic Acids Res. 20:2111-2118 (1992)).
The nucleic acid molecules can also be expressed by expression vectors that are operative in yeast. Examples of vectors for expression in yeast e.g., [0220] S. cerevisiae include pYepSec1 (Baldari, et al., EMBO J. 6:229-234 (1987)), pMFa (Kurjan et al., Cell 30:933-943(1982)), pJRY88 (Schultz et al., Gene 54:113-123 (1987)), and pYES2 (Invitrogen Corporation, San Diego, Calif.).
The nucleic acid molecules can also be expressed in insect cells using, for example, baculovirus expression vectors. Baculovirus vectors available for expression of proteins in cultured insect cells (e.g., [0221] Sf 9 cells) include the pAc series (Smith et al., Mol. Cell Biol. 3:2156-2165 (1983)) and the pVL series (Lucklow et al., Virology 170:31-39 (1989)).
In certain embodiments of the invention, the nucleic acid molecules described herein are expressed in mammalian cells using mammalian expression vectors. Examples of mammalian expression vectors include pCDM8 (Seed, B. [0222] Nature 329:840(1987)) and pMT2PC (Kaufman et al., EMBO J. 6:187-195 (1987)).
The expression vectors listed herein are provided by way of example only of the well-known vectors available to those of ordinary skill in the art that would be useful to express the nucleic acid molecules. The person of ordinary skill in the art would be aware of other vectors suitable for maintenance propagation or expression of the nucleic acid molecules described herein. These are found for example in Sambrook, J., Fritsh, E. F., and Maniatis, T. [0223] Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989.
The invention also encompasses vectors in which the nucleic acid sequences described herein are cloned into the vector in reverse orientation, but operably linked to a regulatory sequence that permits transcription of antisense RNA. Thus, an antisense transcript can be produced to all, or to a portion, of the nucleic acid molecule sequences described herein, including both coding and non-coding regions. Expression of this antisense RNA is subject to each of the parameters described above in relation to expression of the sense RNA (regulatory sequences, constitutive or inducible expression, tissue-specific expression). [0224]
The invention also relates to recombinant host cells containing the vectors described herein. Host cells therefore include prokaryotic cells, lower eukaryotic cells such as yeast, other eukaryotic cells such as insect cells, and higher eukaryotic cells such as mammalian cells. [0225]
The recombinant host cells are prepared by introducing the vector constructs described herein into the cells by techniques readily available to the person of ordinary skill in the art. These include, but are not limited to, calcium phosphate transfection, DEAE-dextran-mediated transfection, cationic lipid-mediated transfection, electroporation, transduction, infection, lipofection, and other techniques such as those found in Sambrook, et al. ([0226] Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989).
Host cells can contain more than one vector. Thus, different nucleotide sequences can be introduced on different vectors of the same cell. Similarly, the nucleic acid molecules can be introduced either alone or with other nucleic acid molecules that are not related to the nucleic acid molecules such as those providing trans-acting factors for expression vectors. When more than one vector is introduced into a cell, the vectors can be introduced independently, co-introduced or joined to the nucleic acid molecule vector. [0227]
In the case of bacteriophage and viral vectors, these can be introduced into cells as packaged or encapsulated virus by standard procedures for infection and transduction. Viral vectors can be replication-competent or replication-defective. In the case in which viral replication is defective, replication will occur in host cells providing functions that complement the defects. [0228]
Vectors generally include selectable markers that enable the selection of the subpopulation of cells that contain the recombinant vector constructs. The marker can be contained in the same vector that contains the nucleic acid molecules described herein or may be on a separate vector. Markers include tetracycline or ampicillin-resistance genes for prokaryotic host cells and dihydrofolate reductase or neomycin resistance for eukaryotic host cells. However, any marker that provides selection for a phenotypic trait will be effective. [0229]
While the mature proteins can be produced in bacteria, yeast, mammalian cells, and other cells under the control of the appropriate regulatory sequences, cell-free transcription and translation systems can also be used to produce these proteins using RNA derived from the DNA constructs described herein. [0230]
Where secretion of the peptide is desired, which is difficult to achieve with multi-transmembrane domain containing proteins such as transporters, appropriate secretion signals are incorporated into the vector. The signal sequence can be endogenous to the peptides or heterologous to these peptides. [0231]
Where the peptide is not secreted into the medium, which is typically the case with transporters, the protein can be isolated from the host cell by standard disruption procedures, including freeze thaw, sonication, mechanical disruption, use of lysing agents and the like. The peptide can then be recovered and purified by well-known purification methods including ammonium sulfate precipitation, acid extraction, anion or cationic exchange chromatography, phosphocellulose chromatography, hydrophobic-interaction chromatography, affinity chromatography, hydroxylapatite chromatography, lectin chromatography, or high performance liquid chromatography. [0232]
It is also understood that depending upon the host cell in recombinant production of the peptides described herein, the peptides can have various glycosylation patterns, depending upon the cell, or maybe non-glycosylated as when produced in bacteria. In addition, the peptides may include an initial modified methionine in some cases as a result of a host-mediated process. [0233]
Uses of Vectors and Host Cells [0234]
The recombinant host cells expressing the peptides described herein have a variety of uses. First, the cells are useful for producing a transporter protein or peptide that can be further purified to produce desired amounts of transporter protein or fragments. Thus, host cells containing expression vectors are useful for peptide production. [0235]
Host cells are also useful for conducting cell-based assays involving the transporter protein or transporter protein fragments, such as those described above as well as other formats known in the art. Thus, a recombinant host cell expressing a native transporter protein is useful for assaying compounds that stimulate or inhibit transporter protein function. [0236]
Host cells are also useful for identifying transporter protein mutants in which these functions are affected. If the mutants naturally occur and give rise to a pathology, host cells containing the mutations are useful to assay compounds that have a desired effect on the mutant transporter protein (for example, stimulating or inhibiting function) which may not be indicated by their effect on the native transporter protein. [0237]
Genetically engineered host cells can be further used to produce non-human transgenic animals. A transgenic animal is preferably a mammal, for example a rodent, such as a rat or mouse, in which one or more of the cells of the animal include a transgene. A transgene is exogenous DNA that is integrated into the genome of a cell from which a transgenic animal develops and which remains in the genome of the mature animal in one or more cell types or tissues of the transgenic animal. These animals are useful for studying the function of a transporter protein and identifying and evaluating modulators of transporter protein activity. Other examples of transgenic animals include non-human primates, sheep, dogs, cows, goats, chickens, and amphibians. [0238]
A transgenic animal can be produced by introducing nucleic acid into the male pronuclei of a fertilized oocyte, e.g., by microinjection, retroviral infection, and allowing the oocyte to develop in a pseudopregnant female foster animal. Any of the transporter protein nucleotide sequences can be introduced as a transgene into the genome of a non-human animal, such as a mouse. [0239]
Any of the regulatory or other sequences useful in expression vectors can form part of the transgenic sequence. This includes intronic sequences and polyadenylation signals, if not already included. A tissue-specific regulatory sequence(s) can be operably linked to the transgene to direct expression of the transporter protein to particular cells. [0240]
Methods for generating transgenic animals via embryo manipulation and microinjection, particularly animals such as mice, have become conventional in the art and are described, for example, in U.S. Pat. Nos. 4,736,866 and 4,870,009, both by Leder et al., U.S. Pat. No. 4,873,191 by Wagner et al. and in Hogan, B., [0241] Manipulating the Mouse Embryo, (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1986). Similar methods are used for production of other transgenic animals. A transgenic founder animal can be identified based upon the presence of the transgene in its genome and/or expression of transgenic mRNA in tissues or cells of the animals. A transgenic founder animal can then be used to breed additional animals carrying the transgene. Moreover, transgenic animals carrying a transgene can further be bred to other transgenic animals carrying other transgenes. A transgenic animal also includes animals in which the entire animal or tissues in the animal have been produced using the homologously recombinant host cells described herein.
In another embodiment, transgenic non-human animals can be produced which contain selected systems that allow for regulated expression of the transgene. One example of such a system is the cre/loxP recombinase system of bacteriophage P1. For a description of the cre/loxP recombinase system, see, e.g., Lakso et al. [0242] PNAS 89:6232-6236 (1992). Another example of a recombinase system is the FLP recombinase system of S. cerevisiae (O'Gorman et al. Science 251: 1351-1355 (1991). If a cre/loxP recombinase system is used to regulate expression of the transgene, animals containing transgenes encoding both the Cre recombinase and a selected protein is required. Such animals can be provided through the construction of “double” transgenic animals, e.g., by mating two transgenic animals, one containing a transgene encoding a selected protein and the other containing a transgene encoding a recombinase.
Clones of the non-human transgenic animals described herein can also be produced according to the methods described in Wilmut, 1. et al. [0243] Nature 385:810-813 (1997) and PCT International Publication Nos. WO 97/07668 and WO 97/07669. In brief, a cell, e.g., a somatic cell, from the transgenic animal can be isolated and induced to exit the growth cycle and enter G_ophase. The quiescent cell can then be fused, e.g., through the use of electrical pulses, to an enucleated oocyte from an animal of the same species from which the quiescent cell is isolated. The reconstructed oocyte is then cultured such that it develops to morula or blastocyst and then transferred to pseudopregnant female foster animal. The offspring born of this female foster animal will be a clone of the animal from which the cell, e.g., the somatic cell, is isolated.
Transgenic animals containing recombinant cells that express the peptides described herein are useful to conduct the assays described herein in an in vivo context. Accordingly, the various physiological factors that are present in vivo and that could effect ligand binding, transporter protein activation, and signal transduction, may not be evident from in vitro cell-free or cell-based assays. Accordingly, it is useful to provide non-human transgenic animals to assay in vivo transporter protein function, including ligand interaction, the effect of specific mutant transporter proteins on transporter protein function and ligand interaction, and the effect of chimeric transporter proteins. It is also possible to assess the effect of null mutations, that is mutations that substantially or completely eliminate one or more transporter protein functions. [0244]
All publications and patents mentioned in the above specification are herein incorporated by reference. Various modifications and variations of the described method and system of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the above-described modes for carrying out the invention which are obvious to those skilled in the field of molecular biology or related fields are intended to be within the scope of the following claims. [0245]
1 4 1 2195 DNA Human 1 aatggattgg actccggtgg ggaaagcggg tgtctagaag tggtgctaat gggaagagaa 60 ttctggtttc aaaagaggat gctctgccac aaagagcggc tcgcgcgctg gcctgggctc 120 tagccgagga gagatcccgg gagaactcca gagctccggg ggagcgctcc tcggaagacc 180 ggggccaaca tgcctgtgcg cagggggcat gtggcaccac aaaatacatt tctggggacc 240 atcattcgga aatttgaagg gcaaaataaa aaatttatca ttgcaaatgc cagagtgcag 300 aactgtgcca tcatttattg caacgatggg ttctgtgaga tgactggttt ctccaggcca 360 gatgtcatgc aaaagccatg cacctgcgac tttctccatg gacccgagac caagaggcat 420 gatattgccc aaattgccca ggcattgctg gggtcagaag agaggaaagt ggaggtcacc 480 tactatcaca aaaatgggtc cacttttatt tgtaacactc acataattcc agtgaaaaac 540 caagagggcg tggctatgat gttcatcatt aattttgaat atgtgacgga taatgaaaac 600 gctgccaccc cagagagggt aaacccaata ttaccaatca aaactgtaaa ccggaaattt 660 tttgggttca aattccctgg tctgagactt ctcacttaca gaaagcagtc cttaccacaa 720 gaagaccccg atgtggtggt catcgattca tctaaacaca gtgatgattc agtagccatg 780 aagcatttta agtctcctac aaaagaaagc tgcagcccct ctgaagcaga tgacacaaaa 840 gctttgatac agcccagcaa atgttctccc ttggtgaata tatccggacc tcttgaccat 900 tcctctccca aaaggcaatg ggaccgactc taccctgaca tgctgcagtc aagttcccag 960 ctgtcccatt ccagatcaag ggaaagctta tgtagtatac ggagagcatc ttcggtccat 1020 gatatagaag gattcggcgt ccaccccaag aacatattta gagaccgaca tgccagcgaa 1080 gacaatggtc gcaatgtcaa agtttcacgt tcctggatgg caggggggcc ttttaatcat 1140 atcaagtcaa gcctcctggg atccacatca gattcaaacc tcaacaaata cagcaccatt 1200 aacaagattc cacagctcac tctgaatttt tcagaggtca aaactgagaa aaagaattca 1260 tcacctcctt cttcagataa aaccattatt gcacccaagg ttaaagatcg aacacacaat 1320 gtgactgaga aagtgaccca ggttctctct ttaggagcag atgtcctacc tgaatacaaa 1380 ctgcagacac cacgcatcaa caagtttacg atattgcact acagcccttt caaggcagtc 1440 tgggactggc ttatcctgct gttggtcata tacactgcta tatttactcc ctactctgca 1500 gccttcctcc tcaatgacag agaagaacag aaaagacgag aatgtggcta ttcttgtagc 1560 cctttgaatg tggtagactt gattgtggat attatgttta tcatagatat tttaataaac 1620 ttcagaacaa catatgtaaa tcagaatgaa gaagtggtaa gtgatcccgc caaaatagca 1680 atacactact tcaaaggctg gttcctgatt gacatggttg cagcaattcc ttttgacttg 1740 ctgatttttg gatcaggttc tgatgaggta agaactgctt aagattctta ttttctgaaa 1800 gattgcaatt ataaaagtga atctatttta actgcaaaaa gaagagttgc tttgcaagct 1860 tcttgtatct cactgataaa attcattttc aattggggat actacagaat gaaatgaaac 1920 cattttgcca ttgcaaatca aattctttct ctttttgcta agagatgcaa aagattctcc 1980 attctttacc caccaaatta aacttggaaa caagtggtcc atagcacaca gcacattccc 2040 aggatttaaa atctctactt attaacttca cgggtgtaaa actctcaaat attaagtatg 2100 tctctgtttt tcttaactca ttgttaaggg tttgagacag cagagatttg gtttttttgt 2160 tcaaattatt gtgaagaggg ccccctttcc gaaat 2195 2 530 PRT Human 2 Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Gly 1 5 10 15 Thr Ile Ile Arg Lys Phe Glu Gly Gln Asn Lys Lys Phe Ile Ile Ala 20 25 30 Asn Ala Arg Val Gln Asn Cys Ala Ile Ile Tyr Cys Asn Asp Gly Phe 35 40 45 Cys Glu Met Thr Gly Phe Ser Arg Pro Asp Val Met Gln Lys Pro Cys 50 55 60 Thr Cys Asp Phe Leu His Gly Pro Glu Thr Lys Arg His Asp Ile Ala 65 70 75 80 Gln Ile Ala Gln Ala Leu Leu Gly Ser Glu Glu Arg Lys Val Glu Val 85 90 95 Thr Tyr Tyr His Lys Asn Gly Ser Thr Phe Ile Cys Asn Thr His Ile 100 105 110 Ile Pro Val Lys Asn Gln Glu Gly Val Ala Met Met Phe Ile Ile Asn 115 120 125 Phe Glu Tyr Val Thr Asp Asn Glu Asn Ala Ala Thr Pro Glu Arg Val 130 135 140 Asn Pro Ile Leu Pro Ile Lys Thr Val Asn Arg Lys Phe Phe Gly Phe 145 150 155 160 Lys Phe Pro Gly Leu Arg Leu Leu Thr Tyr Arg Lys Gln Ser Leu Pro 165 170 175 Gln Glu Asp Pro Asp Val Val Val Ile Asp Ser Ser Lys His Ser Asp 180 185 190 Asp Ser Val Ala Met Lys His Phe Lys Ser Pro Thr Lys Glu Ser Cys 195 200 205 Ser Pro Ser Glu Ala Asp Asp Thr Lys Ala Leu Ile Gln Pro Ser Lys 210 215 220 Cys Ser Pro Leu Val Asn Ile Ser Gly Pro Leu Asp His Ser Ser Pro 225 230 235 240 Lys Arg Gln Trp Asp Arg Leu Tyr Pro Asp Met Leu Gln Ser Ser Ser 245 250 255 Gln Leu Ser His Ser Arg Ser Arg Glu Ser Leu Cys Ser Ile Arg Arg 260 265 270 Ala Ser Ser Val His Asp Ile Glu Gly Phe Gly Val His Pro Lys Asn 275 280 285 Ile Phe Arg Asp Arg His Ala Ser Glu Asp Asn Gly Arg Asn Val Lys 290 295 300 Val Ser Arg Ser Trp Met Ala Gly Gly Pro Phe Asn His Ile Lys Ser 305 310 315 320 Ser Leu Leu Gly Ser Thr Ser Asp Ser Asn Leu Asn Lys Tyr Ser Thr 325 330 335 Ile Asn Lys Ile Pro Gln Leu Thr Leu Asn Phe Ser Glu Val Lys Thr 340 345 350 Glu Lys Lys Asn Ser Ser Pro Pro Ser Ser Asp Lys Thr Ile Ile Ala 355 360 365 Pro Lys Val Lys Asp Arg Thr His Asn Val Thr Glu Lys Val Thr Gln 370 375 380 Val Leu Ser Leu Gly Ala Asp Val Leu Pro Glu Tyr Lys Leu Gln Thr 385 390 395 400 Pro Arg Ile Asn Lys Phe Thr Ile Leu His Tyr Ser Pro Phe Lys Ala 405 410 415 Val Trp Asp Trp Leu Ile Leu Leu Leu Val Ile Tyr Thr Ala Ile Phe 420 425 430 Thr Pro Tyr Ser Ala Ala Phe Leu Leu Asn Asp Arg Glu Glu Gln Lys 435 440 445 Arg Arg Glu Cys Gly Tyr Ser Cys Ser Pro Leu Asn Val Val Asp Leu 450 455 460 Ile Val Asp Ile Met Phe Ile Ile Asp Ile Leu Ile Asn Phe Arg Thr 465 470 475 480 Thr Tyr Val Asn Gln Asn Glu Glu Val Val Ser Asp Pro Ala Lys Ile 485 490 495 Ala Ile His Tyr Phe Lys Gly Trp Phe Leu Ile Asp Met Val Ala Ala 500 505 510 Ile Pro Phe Asp Leu Leu Ile Phe Gly Ser Gly Ser Asp Glu Val Arg 515 520 525 Thr Ala 530 3 397658 DNA Human misc_feature (1)...(397658) n = A,T,C or G 3 ctagaagagc ctagaggttt tcattggctg cttactttta aagtaaacct tattagccat 60 aaaattcaac attcctagga acgtcttccg tttgattcat tttcattact ctgatattaa 120 agaggaagaa ttacttcggt tcttgatttt gtttagattt ggggggttgt ggttttggaa 180 cataaaagtt gttatgctta cttcctggtt attgcaaccc acctgattca ccttcctaaa 240 ctaaccctgc ttctcggccc ttctcagttc tactctcatt atttcacttc agatttgaag 300 ctgtaactga gaaaataaga acccagctga ctcaaggcac aggcatagca ggctaatgag 360 ctgcaagaac ccccccaaat tctatcatgc aactgcatgt gttgacagga atctctggac 420 ctttatctcc agcaggaaat gagagattca tctgtgttct gcttgagtag attgaaatct 480 tagcaaattc catttagaga aaggggcgtg gagaggggct attaggttca agggggtggg 540 tggggggaag ataacaaaaa tgaagggaaa agaaccaaga aaaactagaa aaacagcttc 600 aaaaacacgc tttcctggca cagcttgtca catttatttt cctaagtctc caggaggact 660 atttgaacag aagtgtctgt ataccctgag attcccacgc tggcagcctt tgagaagcga 720 gaaggaagag gactctattc cgccccttga acccttttct atcctatatg agatggctcc 780 ttagagatgg tggaggagag cagaatgtgg ctagtgtgtt ccggagatga gtggcatcgg 840 aggtcacagc caaggctggt aactcttagc cccacccacc ttttgttcct tccccctggc 900 gctcagcctc acctatttca aactctttcc ttcttttgta ctagtcgctc gcaatctttg 960 gccttctcat ctttggccgt ctcatcttcc tcgcagccta cggcacctgg agaccaaatc 1020 aacccccaat cttgcaaccc tccagggact caggcagaaa ctgggcatgc tcagcggcac 1080 gggcagcttt cagtctttcc cgaggcgcgg ctcagcgctg ggcagggacc tgcgtgccaa 1140 ttcagttcgg gcttcggcac ccacctccgc tgaacccagg gatccgagct gcaccctgag 1200 gctaaatctg cacccttagg tggttcattg tcaatcttca acctgctgag cgccaacaga 1260 gcttacaaat attcctcatt aagaaactgt tttcccacct gtgttttcct tgcagctaag 1320 ggtgctttag ctactgcggc gtgaggagct cagggacgga gccctgtggc cggtggccgt 1380 agagatcacc ttcccagagt agctgtttgt cactgagttt tggagatttc ttggctggct 1440 tccgctaaag cacgcttgag taatccgagc tgtggcggcg cccaagctac caagataaag 1500 agagcgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt 1560 agggggagag ggcggggata gaaacagcaa cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1620 nnnnnnnnnn nnnnnnnnnn ngtgtagcgg gagagggcgg gaatagaacc ntcaaccccc 1680 gcngaccccc agctcccttt tctctctctc cttccagcaa aaccggcaca agtcttccat 1740 cccccctcag ccattcctta ctgctctggg caaccgccag gttaagccca tttgcactgg 1800 gaaattggcg ctgtttggga gaagagaaac agatcgattg cccttgtgac tccccgcccc 1860 cttcccaccc cacccccaca gctccctccc tctttccctc ccccgccacc tcccctcacc 1920 ccgcctcctt cccgttcccc acccccaaac cctctcaccc gcggcagtcc ggtgcgaggc 1980 cccctccgga aggtgagggg aatggattgg actccggtgg ggaaagcggg tgtctagaag 2040 tggtgctaat gggaagagaa ttctggtttc aaaagaggat gctctgccac aaagagcggc 2100 tcgcgcgctg gcctgggctc tagccgagga gagatccccg ggagaactcc agagcttccg 2160 ggggagcgct actcggaaga ccggggccaa catgcctgtg cgcagggggc atgtggcacc 2220 acaaaataca tttctgggga ccatcattcg gaaatttgaa gggcaaagta agttcgtttg 2280 ttctcttctc tcgccctcgc tttctgcctt gttagtgcac ttggcgtcca ccgcttccaa 2340 ggtggggaga ccggcaactc caggctctgt caacttaaga ggctgtgaaa ccgagccagg 2400 aggttcgaat ggcagcggga gtgttcttct gatattaatt ttgatttaca ttttagatta 2460 cggtctccat tataggaggc aatttgatcc tcctctacca ctgctccatt atctgccttg 2520 ctacttaatt tcctactatt ctactatctt aaagggaacg tgctaggata acatgggttt 2580 atattttgag gctgttttac tgtagacttt ctgaaagtcg gaagcagagc agaccatact 2640 attcgaacaa gagaatgtaa atggtagtag cgatgtaaat gactatgcaa actatatttt 2700 accttggtta aactgcaaag cagtggtatg acacggatgc ttgcttgcta ttaatttata 2760 gaagctaaat tttgtattga atcaatgcaa atatatccta agcagggtaa tttggaaaag 2820 cagtatctca tctgtgctgg ttcccgatgc aaatggctca ttattcaaaa taatatttct 2880 attcttttat tatcccctta aaatttccat ctagaaattt aaaaattgaa gtgtaataag 2940 taaatcccac aaagactgaa tgcacagaaa tttaatgttc tcatgtggac taaatatagg 3000 gaataaattg ttgctatata aatatattaa tttaaaatcc tgtatttgtt aacttatctt 3060 cggtcttttc ttaaaactat attaatacat ttgtatgcca tatattttgc ggttatttca 3120 gcactgcatt tagtgatgtg aggatctggt accttgcgta caaactaaac ttgtatatcc 3180 tgcttcacaa tctatgtgga aatagtaaat acaatctgtg atgtaaatta ataagctctt 3240 tatattaaga attcctgcta ctacagaaaa cttcaaggat ctcccaaagt aaaagtaaaa 3300 aggttgtcat gatatttact gtgtgtgtgt aaatattttt cttttgggaa atatatatta 3360 tgaaaatgtg aatctttgcc ttgttgaatt gctattaaat atgaagtagt ttcattacta 3420 aagctagttg cctttgtttt taacatgatg tgtgtaacat gcctaagaga gatagggaga 3480 agccaaagaa taataactac tttgagaaag ttgtattcaa agggccaagg ttgaaatgag 3540 aaatctgaca actacagaat gtttcactgt ttgactttga aaatatttac attacaatta 3600 aatgacattc tgaaaatatc aatgggcagc tgcttgtctg agtgtccact aggaaccccc 3660 gcagttgcag ggcttgagaa ctagtctatt tgggaaattc tattcttgca attttaagag 3720 tggtttctta atactttctg ttaaaattac ttaggatcat taatctcaca tttaaagttt 3780 gtggggtttc ttgtgttttc ttttttcata agggctggag agattagtaa tttggggagg 3840 cacctgcatt tcagagctct tattatgcaa caaattgctt cagtgttacg gagaatattg 3900 tggaagcttt ttcaaagatg ccatactgtc ttcttattac agataaaaaa tttatcattg 3960 caaatgccag agtgcagaac tgtgccatca tttattgcaa cgatgggttc tgtgagatga 4020 ctggtttctc caggccagat gtcatgcaaa agccatgcac ctgcgacttt ctccatggac 4080 ccgagaccaa gaggcatgat attgcccaaa ttgcccaggc attgctgggg tcagaagaga 4140 ggaaagtgga ggtcacctac tatcacaaaa atggtaaaat tcctctattt aggattcctt 4200 ctatttgatc ccattgaaaa gaaattttga ctattaaaag ttcatatgca aagaagccca 4260 aaatgttcaa ttgtagatat atgctttgca tatagtattt tgggatccaa catatatggg 4320 tattctgatt agtggtctgg tagaaacaat tttttctttg aataagggta ctgtaatctc 4380 ttcaaaagta cagtaacata atgtcactga ggttaaaatg ctacaaatca gtcttagatg 4440 ctcctttctt taaggaatta gagaaagatg aacaatgtac tgcttgcatt ggtatgcatt 4500 tggtaggcga gaaatacaga tacagtgtta cttgtttgaa ctttaaaata ctccacaaag 4560 caaatttatg ttgaaaacta tatctaaaac taaaactatt acagttatgt ctcttggctc 4620 tttagcttta gttgataggc aacacctctt gtttcttttg ctccttctta caacattaag 4680 gatgataaat aggaactttt accttgatcc agttaacctg tgcatattca aacaataaag 4740 gctgtttatg tagtcaagat ttgtcctgaa ataagaaatg tagaaaaaat tatgatactg 4800 tggagttatt agtattgatt tttataacta cagcaaatct ggcatcttaa acttaaggtc 4860 atacctcaac ttcgagggca acacctcctg tcaaacttgc tatgagagcc gtaagagtta 4920 gacataatag ttctcttaaa aaattacaca tgtaatagat aggcatgcct taaatacaca 4980 atatatatgt aaatgaactc acatatataa atactcagat atgcccattt taaggtgtat 5040 atatagatat atattcctga atatctataa atctatatct atatatatct atatatctat 5100 acaaaatgat atttgtctag ggcttaaagg taaaattact ttaaaaaatt gaatgttata 5160 gttaattttg ttgatatttc atcatcatct atttcttttt attccactaa cagaaattac 5220 tgaggcagag gggtagctgt tcagattttt agaaaactct taagcttttg ataaatatgt 5280 agtgtgccat agcctatatc atataatgac tcatcatttg gtatactaga gagaaaaaaa 5340 gacagcagga aaaaggtttc agtcttactc ttattttctt ataattcaat gtacaatgta 5400 caattcttaa ttactacatt ttccttaaca tgaagttgag tggttacaaa acattactaa 5460 aaacaggttt gtataacttt gtagtaatct ggaatgaaag caatagtata cgtatcaaac 5520 agatagaaat tgtttttaaa gttcttccca tgtttctctt acttttcaat cagtagtgtt 5580 ggcatactag aaatagccta attgttctgt tgtcttgaaa acatttattg gattgagctc 5640 tcactaccca aatgtaactc atgtcttttg agtatctgat gccaacaatc tggacgtttg 5700 gaataatttg aatgtctgac atttttttcc tattgaatat ttattatgat gccaacacag 5760 tctatattgt ggtaacttca gtgaatgttg gtccatcttt ggtcattatg ttttctagac 5820 catttcaggg atttttccaa ctcatagaat ttaagtatga cattaatctg gattgcccaa 5880 attgctcaaa tactaggtat atctttcaga gtgttttcaa gtaggagtta tctattacac 5940 cgcaagtggc gtgatgatgt tttgaaagtt gtgcaatgtg ggtgtgtaaa atgatctcaa 6000 aacactttaa aacaaattta ataagaatca cagatatgat taattcctat taaattattg 6060 aattttctgt attgaacata ttagtatatt gacaaataca aatctttcta tttgaaggat 6120 tttcttggtt atatgcatta aaactcccct gttttcagaa agggactttt gatttagagg 6180 attgtttggg tataaagaaa ttaaccttta gtaaaaattt tgattctgtt gacttcattt 6240 tcagatgtaa ctcagtcttc aaggatttga atatctttag cgttaactat aaaatctacc 6300 tattttgctt taattgatat ggaaaacatg agaaaatggg tcaagcattt tctttttatt 6360 taatatttta agaaatatat tagtttgaat gaccttttta aacagtgatg acacagtcat 6420 acttgtttgc tttgaaagta ataaacttgt gttttggctg ctagttcaga taacttggat 6480 agaatcttca gtgtgtcttg gttttattta tatgacaact acaaaatcag ttagagctta 6540 tgagatacaa attcttggat agtctcatct cttagagata agactactgc cagctactct 6600 acatttataa aagctggaag gaggaaaatc aaaatcacca acatatttgt tggtttgttt 6660 ctcaaagttt ccgtaattcg ttattattga tgccattgac ttttgagttt cttgatttct 6720 taactgtata cagtaaatgc ttcttttgct tattctttat ttagcatttc acaagaatat 6780 gaagagtgat gtaataagcc caatgaacaa attaacaaaa agttgatata ttctgtttcc 6840 atttcttcca tttgctctta ctggaggagt aaaaatacga ccgaggcatt attttggaaa 6900 gcttgttcgc taaagtggcc cagaggcttt ataagcaatt taaacccgtg atctatgcaa 6960 tgagttcaca ttgatgcagt tcatggtgaa ctgcatgatc gtcattttga aacaccactt 7020 cctactatgc ttctgtatgt gattgtgcta ggcacaatta aacttgctgt ttatcagaat 7080 atcaattttt aaaaacctag ttatttgcag taggaatatt tgacagctct tcctttgagg 7140 attctatttt acagtttaag tcattattgc ataaatcatc cttggcagct gtgaagtatt 7200 gcttgaggtg ataaagctgt aaatcttttg acataaaact ctaattatac aaaactataa 7260 ttatgctatg acttatataa ggatgggcat gtattttaat agcataatac attcatttaa 7320 aaacactttt cagcaacaaa gattaaaaaa tagcaaggac ttcagttatt aactagttca 7380 tagttttaga tgatgcaagt ggaaaggaaa cagaaaaaaa aaatatttta gttagccccc 7440 acaactaagt ttatccctca tctggtttgg agtacatcac ggaagagagc tagctagttt 7500 aagtgctaaa ccccttcagg catatttaca aatgtgactt tgaccttaaa ttatcaagca 7560 actttaaaca tttgaaaaaa caaagtaaat ttctccagga aaaataaacg tctttactca 7620 gtaggaaagg atgacttaaa atatattatt ttttgaggtc agagcgttcc tgtattttgc 7680 cattatgctt tcatacacac tatggtagca attttactaa cagatcagaa atgtatggtg 7740 ctacttttct tatcttcatg ctgcttttaa agaactgaag aatgataagg gactgaggga 7800 agtccttgcc taatccagtc agatatcagt agaaagtttc agaggtagat tttgattaag 7860 taaactcaga agaggtcttg gtttgatagc attgaattta ctatgtctga aaattatgtg 7920 gaaagacctt ctagaaacag ctgtgttttt gtgaatcaag gtgaagatgt atattgagtg 7980 cctcctctct ctctcatgta atgtaccagg cactgtaaga acagtaggaa gagatacaaa 8040 ggaagatgca acctgatctc tgcttccagg acatttgtat tacagagtga ctaatattca 8100 tttccatcct ctaaatctca gctgttttta taaaattatt tttaatggaa aaagagtatt 8160 tggactatgg ggttgttaat tgcatagaga acctgcaaaa tttattatta attgctattt 8220 tccttctatt ccccaaattt aaaataaaca tgcttatgtg tatcttcttt tcaccattgt 8280 catgtataca taataatgta ttaaagaagc aatgaagttt agttaaaatt ttattagtac 8340 aaacagaaat ttcacaaaat ttcataatag ctttatataa gttatatggc atgtaaaaca 8400 ttcagctctc ttaattcttg gattgtgtag aagagataca gatggtagct ttttagacaa 8460 gaacaaaaat atattttatg tgtgtgtaat tcaagcaatg agaaagattt tcagagcgta 8520 tcttgcctag agtttgcttg ggtgttcatt ttaactttct gtttatacat ttttacattc 8580 tattcaatag actattgcaa caacagtaat cctaaaattc attttctctt atgtgcccaa 8640 attttatatc atctcatgga ctttgaatgt tatccagaat tcaaatttga tcagttgtaa 8700 ttgttgataa aataggcatt cttaagaaat gctcttcccc acaatttgaa aactatttca 8760 gtattgtcct aagtgaaacc aaatgtccta aaactgtggc tgagctttgt ttatcagtta 8820 cttttcacca ttcaccaaca tcacacctct aagaagctct ggtaccaaca agaagccatg 8880 ttgtctgcca gcttgagaga gaaattctta gttattttca cacccaaggt gcttgagaac 8940 aggtcagttt aggactgaat gaacaggata agtttaacag gagaaacttg cttttactgg 9000 cttccaaagg tttttggttg gtttgttggt tggttttggt tttgttgctg ttgttgtttg 9060 gtataaataa tctctgaatc cattgctggc aatctggcct gccaggagag tacccggtta 9120 gttgagccac agggaagtaa cagttggtgt attaagtttt gaggtgtcac cattcatctg 9180 ggatctatac tagaaacttt ggtgtcattt tccatttttc ttcatccctc agctccctaa 9240 agccaactgg tcaccaaatc ctttcaatct ttacatcaga aatatttctc aaatagcatt 9300 gagagatatt cgaagtggtc tgattaaagc ctgctgtcct tccgaagtat tcaagtatct 9360 agtttctctc ccccgatcca tcctctacat actgggagag agctattccc aaaacatgaa 9420 tcacctatgc tgatggctta ttagcgccaa gaatcactga aagtaaattt tatatattaa 9480 atagtgggta caaccatctc ataaaatata tattcttatt atctccgttt tgtggaaata 9540 acactgaagc ccagagagac tgaataattt gccaaattgc acatagctca tacacagtgg 9600 agtctgagcc cttaacaact ttgtcttact gctactcgat gtacctatat cagacctcag 9660 cttgaaaact tgttttcagt cattaaacca ggatactggc tggcttcaga attgaattca 9720 cttgggattt caagtattgt gttgtcttag tcttttccta ctgtgataac aaaatacctt 9780 agagcgggta acttataaaa aatagagatt tatttctcac agttttggag gctgggaagc 9840 ccaagatcaa ggcatcagca ggttctggga ctggtgaagg ctggctcttt gctttcaaga 9900 tggcactttg ttgctgtggt ctcacatggc agaatgcaga aggctaaaag gggcagtcag 9960 ctctctgaag cctcttaaag gcattaatcc cattcaggag agtggagccc atatgactta 10020 atcacatccc aaaagtctac acttcttact actctcatgt tggggttgaa gttcgaatgt 10080 atgaatgttg aaggaacact acattcaaac cattataggt atgtttagag aaatccagct 10140 ggattcccag ctctgataac aactagatga acttgttgga gtttaccttc ttcatgcctc 10200 acttttcttt actgataact atttggagaa tataatctat gttgttaggc ttattgagtg 10260 tgttgcatgc aataaagaac gcagcattat ttctggcatg gtttccataa tgtgttcaat 10320 aaatatcaat tagttgaata tattgccacc ttcatttctc ccacaaatct tatgatccag 10380 tcatacttga ttgctcagag tttcttaaag aagtaacata tttttcttct actgaggctc 10440 tgtttagtct ttagaagttt ttctttacct ataatgaata tttcaaagac tttctaaatg 10500 gattgccctt ctctcagctt ctcacccgaa agaaaccatc atcgtccttt caaagacaga 10560 tcaaaagact tctctgtgaa atccttcctg atgttcccac tatctgcact tctgtctcct 10620 catagcactt ggttctaggc tccagggtag cctctgaaga gtgctccttg ttattacgca 10680 ttattgtagt taatttagtc tatttttagc ttattcagag aaaacaccaa gtcttattaa 10740 tttctgtgtc caggatatat ggaagggtaa ctagtacgaa gtgagtgcac tgttagtatt 10800 tacttaaaga atgaagagaa gatgaaaaat ggtaccatgc agttagaaaa aaaaaaaaaa 10860 cagataaagt taacaagatc tgggggaaag tgtgttatag gaaaagtgta atgctttgtt 10920 tttttttcat tttcttaaga acacttctaa aatattaaaa acaattttta ccataatttt 10980 attaatggct atatgttttg tttagtaatc taagatatta aatcatcttc atagcctgaa 11040 actatatgaa tatgaatagc tagaaaaata tttagtgaac agttggaatc tactcaccag 11100 aaattattaa cctgttacct aagtgtcact cacttgctac cccaccaatg acttaccagt 11160 gtctccaaca atctctaata gcccaaacca gagttttctt ctgttctttt ctaacttgat 11220 ttcattgctg tggttggcac aattatacaa ccaactgaat atgttacaca ctctattggc 11280 attttatatc tagtgcaact atttatccct ccatgttttc ttgaaaattc ttaatcagta 11340 atgaagcttg atttcagagt tatacaataa tggcaattga aaatgtaaaa tgataaagtt 11400 agctgattaa tcattaatta ttataattgc caagtgaata ttttctctct ctttactgtg 11460 ctgtctgcat ttagcaatag tactgaacta ccaagaagca acagagtcag gtagctataa 11520 ggcactaatt atagtagtga ggaaatacgt cttattactg aacaattaag aaagttaatg 11580 ggttatgaga aaacagaatt ccaggttctc atggctgtga ctgaatattc cataatctct 11640 gcctcatcct cctttaattt acatgaaata tctaattaag aaaagcaatg ggctctttcc 11700 atgatagcct gaatcatggc tgaggcgtct tctatgactt ttcccaagtt aaagtaggcc 11760 tgcttgtgtg caaacttgtc cttttcatga ttcccactgt tttgtagaat gtctcacact 11820 actttttact cagaaaatgg gtaaaaacag ctgtggctgg tgctcagtgg gcaggaattc 11880 aagggaggag tgagagagga ctgtgggtac atttctgcct ttagttggct cattttgtaa 11940 aatgatctca aactagactc tgccgggcag aatgtgtgag gttccctgag ccacgtggct 12000 tttgcttacc tgcactttct ttccagatga gtcagaatac agtgtaacag caagtggact 12060 ttcaccattg tgggttttat tgtttccttt ttctgttttt attttgttcc ttctctcttt 12120 ttttgagatc tttaggagtg tttttatgta tcattctttc ttaattttga taggacatta 12180 attcttttgc attttttgaa atattgattt tgagaaaaat gtaataactg catgagttca 12240 agacaagtta aaatgtctgt tgcccatcat gtagattatt gtcctttagc ctcaaaacac 12300 tcttcttact tatatttagt gaagtctgta tcaatgactt aagatgatga gcatgatgat 12360 aaaaattaaa atacaaacta gtggtggttt tataacaagt aacaaagaac aagtaataaa 12420 taaaaatcca tttgtgctaa aaaagatcac atgttgtaac ataatcttaa ggtatttgca 12480 tatactaaga ttatatcaat tggacaaaat caatgttaga gctatgcaag gttgcatggt 12540 gtgtgaatat tttttaatga agtttctgtt tacctcttag ctaaatccat taaaatttct 12600 tctgggtttg ctaaaaagtc tatatacact atctgttttc tttaataata atagtaatca 12660 tttgatcttt agccgtacat ttattcaagg ggtttacatg caacagatgt gctcttcaga 12720 ttttaatttt tgtggttgta tgcaatggac accagccctc tactcaggat agctcttctc 12780 ccaaaggtct aacattgagt tccaactcag tgactggttc ttcatataaa ttgctttcag 12840 tgattttcat gacagctttg ggagcagacg ttatcccatt ttacagataa gttaaattga 12900 ggttcagaga agttaagtac taatgatcac agagcaatgt ggaaatgtgg tttacaattt 12960 acatttatct atacttgcaa actctaccac attgcctcca aatgatacac ctcttaaacc 13020 tcaacctact ctattctgta tttcctagtt ccagttctta aacatagatt ctattgatta 13080 tccaaggttt aaatctggtt aacttaattc acatcaaaga gtgaataaag catggcattt 13140 tgcattttta acagaacttt atcaatcaaa atgaatatca ggcagagtgt tagattttag 13200 tagaatgagg atagctagta tatgcttata atctgcatca ttttaaatgg cattctcttt 13260 tactcttaaa atgtcccagt tttggactat atattgtatg actgacttag attttggggg 13320 catttttggt taagggcccc tcagttacta tatgtctagt ctttatccac atagtcaggt 13380 agaaaattca tggagtattt tgattcagta gcagggacat acatggtgtc cttttcccct 13440 ctccttccca caagaaagtt ttatttcctg gcaagattat gtgatgtaac aaaattcacc 13500 actagtattt taaagggaaa gcataaatat actgtgtgga gagcgtctgg tttatttaaa 13560 atgcctccaa ttttctacat cttgagccaa atgtcagact cacttcctgt tacacagcct 13620 actatcttat ttccctgagc tcctcctaaa ggctgtcatc ctcaggactc ctccctttaa 13680 ccactgggtt tcttcttcct gagatagcct taatgtcccc tccctgaacc cttcatcaac 13740 tctcctccac ttttaagcaa attctgtatg gcttcaatct cagctcattt ctaaggtctc 13800 taagtccctc aggcagcctt ctccacattt ctcatgtgtt ttccttttct ctattggaac 13860 acttatgaaa ttgtgttgta gtaatttgtt tctatgtctg tctttcccac tccatgttga 13920 acattttgaa gggacttatt aaggcagtta ttaaaaagta gaagaaatgg gagagcaaag 13980 aacagactta cgagaaccca gcaatacacc catttacaga tgaatatctg tgaaaggtgt 14040 cagagtctgg aaagatatca ttcattcatg cattcaccat cttgtgtttg tcattttgct 14100 gctatgagaa tggtgaaaat caatctctaa cattgtttat taactgagaa attaattatt 14160 aacttgctgc catatggttt acatattata aagcaatgta ttctaatact taataacctg 14220 taactcatta taaaaagaca taacaaatca ctcttcttag ttagcctaga agggaaaagg 14280 tgaatggtca gaagagttca gatagatccc tgatgccaac acagttgact gattctgatg 14340 gaacatccac aagttcaata aaaggaaaaa tatctctaca tgttctcata ataatataag 14400 catgtttaca aaccatccca gccctccctg gatctcctca gttaaataca catgacaaaa 14460 tacttataaa accttgcaat tatgctgatg tatttttctg ctatctttct ctacacattg 14520 gaagcagctt catacttaca ctggtcccac agcacattta attctttttt ccaaaccttg 14580 ggtcatgggt tgagattgta aggcctgtat gatatcagaa gacacttcat cagtcacatg 14640 ctgatacagg atttcaccac ttcaacaagg acttatatct ctactctctg tctctgtcaa 14700 agtgatttaa cctcactgtt gaaacattag aaaatacaga gagaaaatag aaaaaaaacc 14760 ataatcttaa tactaacaga tatccactgt tacaatgatg gcttgtagtg cagctataat 14820 ttttctacac aaatacacac atgtgagcat tcatgcatgt ttttaacaag accagggcag 14880 cactatatgt atcacagctt gtagcttgtt ttcctcactg agaaatttct gctgaacatg 14940 catatttttt taatgattac ataaaatttt tacacagacc ataattgttt taatatccac 15000 agaatattac caacaattat tacttaataa taattgagca cttgactatt tctaactttt 15060 tactgttgta caaatgtacc aaaagtctgt tcaaccatct tgaccacctg tacttttttc 15120 cttactaaat agtcctagaa gtataattac tgcataacag tatgtctatc ttaaaacttt 15180 tgaaatctct tgtcaaatta taacagcaaa aaggtatata tttaactgca cattttatgt 15240 gtccaataaa acttagcatt ctttttaatt tttgttgatc tagtagaaag agtaccttat 15300 tgtctgatca ctaaatgtga tccaattcaa tttttgttga aatttgttga attttgtaat 15360 tcaaatttta ttgaaaaaca catgtagaaa atatttgagg caatttattt tcccattaaa 15420 aaaacatgct aagtattttg aaacctaggg agcaatgagg atctcttgaa tagctgagta 15480 tcctcgctgg atgccccact tcacaccagc ttcagtattt taaaaactga tcttcacatt 15540 cacattttca tttcagtaat ttgctggcat ttttccaaac ctcagattca gaaactgata 15600 ccaagtcttt actatttaaa taatttacta tttaaaagtt caaacactcc ttgaactttt 15660 cctcctttct atgtggaata agttggattt taagttattt tcagtatttc ttatatattt 15720 caatatttct tatttattat ctaaatatac cataatgaaa attataacta atgaaagagc 15780 ttttcttcag tagtttttat ttgaatatac atatatacat tgagattaaa atatactctc 15840 tccctctctc tctacatata tatatatagt tttgctgaga tgcaaactga tggccaggaa 15900 agttagcaaa gtcataataa ataaacaatc ttctaggata tcatgtaaca gaagtgaaat 15960 tcacttatga aatgccactt atagtgacat caaatgctca aaattacata tgatacgtga 16020 ggaaagatat aagcaacaga attataacac agtatcagat aaactgctaa atttattcca 16080 atataatagt attgaaatga atgtagggaa agattattct cttcctaggc tgccttattt 16140 aaccaagacc tgcagagctc tggtaatctg atctttctag ctgtgactca attgtcaggt 16200 cttccctcca ggtgttcttt ataatgaatg tcacttaacc aaggctcagt aggatttatg 16260 gattcccaga ttgctgttct cagaatttgc cccccaatga aggactacac aaaaatgcca 16320 ttaatgatgc acaacctcaa ctgtcctatt agctggcatc tattcattcg aaaattgcag 16380 aacttgtttc tttgcaggtc atgtttccag agtaagcaga aggtgtccta gtgaaatgtc 16440 atacccacca acattcttta ttttaaatat actcactgtg tatagtgtga gttacacaat 16500 attttgtctt aattactggc tgccccaata acttcaatga tgaatttttc tctgaagaat 16560 acttcatctc aaagagttaa tactttttgt tattaatcta aactttttga aaatatcaag 16620 aatgccgatt acagccttta aatctttacc aagtaagatt ttataatatc attcgtgatt 16680 tttcttcaat attagaaaat aaaactaaat gttggcagag ctaatgctct gctacagaaa 16740 tgaaaattaa tttcgagtgt aaaagaataa agtattttca taggtacttc ttatatggca 16800 attaaaaaat aactggtaac atctaaattt tcttttccag aaggtaatta gagattttag 16860 ttagactgtc agcatttaaa aatctataaa tttaaaatat aaagaatgaa gatgaagcct 16920 gctcttttaa ccactttagt tggatggtga aattcctgga aaagacaaaa gaaatctcag 16980 gcattgaatt ttcattccag cagaagttat gtgtgctaac ttctgttaaa gattccaaga 17040 aacatggact aaaaaagacc agagactttt tctaaaagta atgacattat tatactatga 17100 agtgtaataa agactatgtt atagtataac caggcagggc cttcttgcca ctaatcttgt 17160 tgttctagaa atggaataat caacccctcc tcattaccac acccacttta actataactc 17220 aaggcagaaa tcagatcctg gaatttttaa atttttgttg attttagttt ctttatttta 17280 cattcatgaa cactagtatc ttgctaatta tttcaaggat tgggctaaat tattctgtgg 17340 caacatatga aattctgtaa ttagagataa ttaaataata gagtgtggtt tgaacatttt 17400 aaataatagt actaataagt atcattgagc acttacaatg tgactatact cttctaaaat 17460 cttttttttt tcaattttta gcatatccga agacatagat attttattgt tctcatttac 17520 aaattgaaaa gatgaagttc aataacttcc tcaacactgc aaaagtagta catagcagct 17580 accatctgag tgcagactgt cttcttttag agcctgtgtg ctcagcactc tactgtacca 17640 cctcacccat ctcctgttca cgtagataca atgacacact cactacacac atatgtggag 17700 tcaggtctcc ccttgatgca aagtgtgaaa tgtttctgga ttttaggcat ttaaatgttt 17760 taatcttgga ggcttgtaat cttctttcct taaatgcaat taaacatctg cctccagctg 17820 tacaggagtg cgggcttgtg cctttgacac ctcaatccta ttctccttta gaagcaacag 17880 gcattataat acctgtgttt cccatgcact gtaaggttta aaaaccattg ctataggatg 17940 atctgattaa catggcttct ggagggtttt agaaataatt taaattcacc tctgtttccc 18000 acaattcctt gcacagagta gctgctcaat aaatagtttc tttaaataat tgaatgaatt 18060 gaaacattag acacattctc ttaaccaagt ttccgtttga tctattagtt acttctttga 18120 taaagtgaaa gtagttcctt acctgtttga aagggatgat aaggagggag catagtctaa 18180 tgtttcatat tgtgaacact ggagtcatgt tgcctaggtc caaatctgga acatacacat 18240 tgtgtgatat gttacctttc tgccctgtcc tcactttctt catcagtgga aatggaaata 18300 tgattataat agaacctatc ttattcagct ttgtgaggac cgtgtttaca tttgtaaaag 18360 cacttaaaac agctccaggt acccagtaaa tgcaatagaa gtgctaaata aaataattta 18420 aaaatgtgat aaggaattgg gtttaaaata catattaagt tgatatgcct attgagtgtc 18480 gtgctcaaaa tgaagtttgc acccacatct gtggctgagt aaaataatgt aaaacaaatt 18540 tttacatcat aggtcaaaga agaaattagc agcggttttt gaaaatttaa aatgtaaaat 18600 tttaggggct ttattgtgga gattatggcc tcaatcaaat tctggacaat ttaatttgtt 18660 tttaattttg aacactgaaa ctcaatttag gtgtggctat attgaaaata tcagcagttt 18720 ggacaacttg gactcccagt ttctctgtgt acagctgtct ttcagctata ttaaaacaat 18780 ttcagtatgg tgtttcagaa accactgtgt ctgaaagtaa aagttcctca attcacacag 18840 tgaggtgtaa actcagtcca acactccact ccccaggatt tagtgagaac caagataaat 18900 tgtattgaaa gtaaagatgt aaaaataatt gtaaacctat cttttgaaga aagtatgtag 18960 atgtaaatgt ccaaatataa gcaccacagt taaggtgatc gtatgattta ttatccaaag 19020 caagattctt tttaaagtga aagaagaaag tttttacaaa ttgtaccaag gggataggaa 19080 aaaaccagga ctgttccagg caaactggat atgtagacac tctgaataca aactatatct 19140 gacatttttc aaaatgtatg ccattctaca gtacagagtt ttcatgaaca ttttttaggc 19200 tttccaaacc agtgagttta aaaatgtagc cactcattct tgtgatgcct aaaatgttta 19260 ctgtgtagac aaagacagta tcttgcaatc tggagaaatg agtcagaatt cctctaaaga 19320 ataaatggca ccttctgacc tctttcaaat aagactgcca accaatccct ctgtaaattc 19380 catgttgaag gttcttagta aagagaatta accttaaccg ttttgtgaac catagtaagt 19440 catgagcaca gcaatggact aaaggtaaaa agattgaatt cattgttgaa tggcaacagt 19500 cccttacaag gtatctttga ctttgtaaag gatgtttatc ttggaatctg ttaaagtgtg 19560 ggtgtggata gggtatgtgt agaaccattt ttttctttct ggactctcca ttaggcctta 19620 gttatatgtg ttagtctatt tgtaatccag tgataaaatt agccttgtat tgtgtgtaac 19680 ctttgttgtc taaaaggtgt ttattaagta ggagggacac ccctgaaaaa gctggggctg 19740 ctagcattaa agcagcaagt tattaacatt ctaataaaaa caataaaaaa taatgaatta 19800 attcagattt gtaatataaa gtaaattcat tagttctcat gtatttaagt agaaaatgat 19860 gtcttcaaat ttcaagagaa aagtgcagat atcaaaaaat caaaattaag gaataagaaa 19920 ttatttctca gaggaaagtt aaaggaaagt gatatagctg gtatactcat atttgtattt 19980 ttgcagatct aatacaaaca taagggaaat tatctttgtg aaaattgagt ttgtaagcaa 20040 atttagcttt tgcagagtta caatccaaga aagaaaaaga aagaaagaaa gaaaacacaa 20100 gttagccact atatatcttc tcccttccct tcccttgcag attcaactaa ctttttcttt 20160 taaattaccc ttgaatgttg aggtcattgt atgtgatgaa atagtaccaa gaagatgcag 20220 gcaaagtcaa tggaggtata aggaattata cctttcacac ctaattgcct attttcctgt 20280 tgacttatgg tgtacccttc attttgtatt tgttcagtga aagtttatgg aataggctgt 20340 gcgtggtggc tcacgcctgt aatcccagca gttttgggag gctgaggcag gcggatcacg 20400 aggtcaggag atggagacca tcctggctaa cacagtgaaa ccccgtctct actaaagaca 20460 cacacacaca cacacacaca cacacacaca cacacacaca agattagccg ggcgtggtgc 20520 tgggcgcctg taatcccagc tactcctgag gctgaggcag gagaatggcg tgaacccagg 20580 aggcggaatt tgcagtgagc tgagatagcg ccactgcact ccagcctggg cgacagggcg 20640 agactccacc tcaaaaaaaa aaaaaaaaaa aaaaaagttt atggaataaa gaaatacccg 20700 aacaaacaca ctgtagaatt tatgtaatgt gtggggatgg acattgcatt attgtgggtg 20760 cttatatttg cagctgaaaa atattgtatt tttccttttg atgaactaag atgatacaaa 20820 aaccaaaaca aaataaacaa aatccaaaaa acagcaaata ggctttcatt cggaattatt 20880 ttcagtttag cctttgtgaa tattattaga aaagaatagc acattatact cttagtttag 20940 gagccattta ttcttgttca ctactctgcc ttttccccca actctttatt ctagggaaat 21000 attgtcctgc ctccaaacta agcataacaa gccaaggagt gtagaaatcc ttagcaactc 21060 aaaagaaaat ctgtctttca agtggcaacc agattagcat ggttcttcct aaattacagg 21120 aaggaatgat ccatatacct aaatttacta gtatcatttt aattaaaatt tctatttcaa 21180 aaaatactct gacctacaga agagttgcaa acatattaca atgaaccctc ctataacctt 21240 cgagtagatt cagctattgt ttataagttg cctcatttgc tttagggtgc tgcacatttt 21300 gtctgtgtca tctatgtgta tacacattgc tattttatat ctacttattt attttgctgg 21360 gccatttgaa tttatttgca cagttacaga cccttcattt ttaaatgctt caatatttta 21420 ttttctaata ataaggaaat tctttaatat aaccacaact taattattca ggcaatgtta 21480 caaggataca atactattat ctaatagact ctataaattt ttccaatttc ctcatattgt 21540 cctttagatc atttgttttt aacagttcag gattaaagca gtatcatact gtagtttgtt 21600 ggcatgtctc tttagtctcc tttaatctgg attacttatg cagctcttct tgtctttcat 21660 gacattgata ttctttaagg gtacaggttc attgttttgt agaatgttca attttgattt 21720 gtttgatgaa tcctcttgat gtgatttaag ttgtagattt tcatcaggtt taataaataa 21780 gtcatgtgtc ctactttgag catcactaga agcacttgat gctggtttgc cccataattg 21840 gtggggttaa ctttggtcac ttgccgtgcc atgttttaca tgttgtgaaa aaaacttgaa 21900 aaatgaaatt taacaatacc ctgtaaatag caccaataga ataagttgga caaaaatgtg 21960 caagacttat atcataaaat aatcataaac atggctaaga gaagttaaag gagaaatagt 22020 ccatattcat gaattggaac ttgaaatatt gaaaagatgt ccagtcttcc caaattgatc 22080 tgcaatcttt accaaaatta tagcagacta aaagtcattc aaaaatttgt ataaaaatgg 22140 aaagaatcta gaataaccca aagaaacatg gaaaagaaca caatttgaag actcaaggca 22200 cctcatttta agaattactg taaagccata gtaatgataa cagtttgata tcagcataat 22260 ataaataaat aataatcaat gggacaggat aagtccaaaa atagatccac acatatatga 22320 tttaattttt gacaaagcac caaagtaagt cttttcaaca aatgagctag attaactgga 22380 aaaatatatg agaataaata aatattgacc cctgcattat actgtgtaca aaaattaatt 22440 tgatttagat tacatactta aatataaaag ctaaaattat aaatttttga gatataaaca 22500 aaaatatctt tgtaactgtg agcaagtaaa tattacaaag aaagaataca aaaggcacta 22560 actataagaa taaaaaataa tgaatatgac atcatcaaaa ttaaaaactg atacactgca 22620 aagcattcca ttaagaaaat aaaaactgta tatatgtata tacacagttt ccattaagaa 22680 aataaaaact gatacagact gacagataat atttaataca tttatttgac aaagaaattg 22740 ttttctacag gtatgtacat atatattaaa tatgtccata tctctctgta tatacatata 22800 tgtgtgtgtc tacaatcagt aatgaaaaga caacccaaat aaaaacagat gtaagaggct 22860 tatgtagaca ctccaccaag gaaagataca caatgggcaa taagcatatg aaactggaag 22920 tataatttaa agttaagatg ctattagcac ccactagaat aggtaaaatt gaaaagactg 22980 agaacaccaa atgttggtga agatgtggag caacggagac tcatgtattg ccagtgagat 23040 taaaaaatga cataaacatt tgaaatactg tatactgttt cattataaag gtaaatatac 23100 atctatatgg cccagcaatt tctcttctag gtctgtatct aagaaaaatg aaaatatatg 23160 tccacaaatg atttatatga aatatttata gtggttttca tttataatag cctaaatctg 23220 gaaacaacct aaaagtctat catcagcagg ttaatagata aattaagttg tggtgtagcc 23280 agacaatggt acaccaatca ataataaaga aaaataaact attgatataa aaaatgcatg 23340 atttccaaaa acatgttgag caaaaaatgc cagaaacaaa agaatgcgca ttgcatatct 23400 ctaattacat aaagctcaag attaggcaaa actaaactat ggtgatataa atcaaaacag 23460 tagttgcctc taggacgggg ggttaaggat tgactagaag agaacacaca agaattttgg 23520 ggaatgaagg catattctac atcttgattg ggtattgatt acttgagtct atgcattggt 23580 tcaaatctaa cacattgtat aaatttgcat ttcactgtct gtgaactttc actccataag 23640 atcactgttt actttcaggg ccagattttt tcttctataa ccacatgatc attacccaga 23700 cctagtaaga caaataaatg cgtataaagg aaaatacatt cttgaaattc tgggctttta 23760 cttttatata taggaaaatt ggcttgtatt taatattctg ttagttgaat tttcattata 23820 gcagtttaca attcatttct gtatttttaa aaaaaatttt caacattgaa agatactaga 23880 aatatcctga tatagtagac aggatttatt ttcatgattt aggaaatcag ggctactcat 23940 actgataagc cattggttta gtttattttt cccactttcc tttcatattt tagcaacatc 24000 tcaaacaaac taaatctatt gttacacgtt ggcatattta ctatccacac ttatttctta 24060 tagcagtggt gaatcagaat ttttaatcaa gtatttcatc ctcttaaaac tatatctaaa 24120 ctaattgcat ttaattcttt cctatattag gaggtgatgt atcaagtttt gattaggggc 24180 attattttta ttcttaagtg gcaaatagat cttcaatagt ctctgagccc tcagggtagg 24240 gtactttcta ttgatttgct gtttgtactt tccacttcta ttagggaaag ggcagaaatg 24300 accattttaa tgaaagtcaa tttttctttg atacagattt caaactaaaa caaaacacat 24360 agtcagtgaa gaaaggaaac tgaaatgatc ggaatgtaag gcagatttct ttctttcttt 24420 gtcttttttt tttttttttt tttttttttg agatggagtt tcactcttgt tgcccaggct 24480 ggagtgcaat ggcacgatct cggctcacct caatctctgc ctcctggatt caagtgattc 24540 tcctgcctca gcctcctgag tagctgggat tacaggcatg cgccaccaca accggctaat 24600 tttgggtttt tagtagagat gggtttctcc atgttggcca ggctggtctc gaactcccga 24660 cctcaggtga tctgcccgcc ttggcctccc aaagtgctgg gattataggt gtgggccact 24720 gcaccctgcc gtaaggcaga tttctaagta aattttttta aactggagga tgaggttatg 24780 aggaaatcta attatgtaat ccaaaagata catgtgtgct acttatgtgg tcagatggat 24840 ctcttcttca ccataatcct gaaatttaga tgtcagaact ttgttggaag actgaaagaa 24900 agcatgttta agtgtatggt taaactggga ttaatatggc tgtgcccaag aggtggtact 24960 ggttgtattt ataaatacgt tttaaaagaa aagttgattt gtggctgcta gagctgagac 25020 aagcatatct gagatgcaca attaacattt tattgacttt tgagactgac ataaactgtc 25080 ttcctcagtg tttgtctgcc ccttgccttc cagtctgtgt aacccatcag ggcttcctga 25140 cccaggtttt attgtttctc actttctttt attctttatg tttaatagct tcaaaatcaa 25200 ttcaaaatca catctaaaac ctactgcaca tacagttgca ttacttcata agatttttat 25260 aatgacagaa tgtttactca taaggagtgc ttgaactgca tcctaattat tgtgttatgt 25320 gataagccat tatagcttat tgaacacata tttatgtttt tgtgggaaaa aacatgtctc 25380 attttttaat attactctga ttacttatat ctatttgtaa tctttaaagc ttccctagtt 25440 tcaatagaag gctaagtttt aataattctt ttcctcctat tataaacagc cagaatgttt 25500 agaataagtt gaggggtaaa tatatcttct cctttatact gaacattaga ttaagatgtg 25560 tggtctttaa atttgaaata tttgaagagg ttacttattt tatgaaaaaa atatgactct 25620 tggagtaaaa agacaaagtt catatttgtt acttagttat tgggggaggc aaagtaacag 25680 acaaatgcag aggcagaaaa aaggggagga ggaattcaaa tgtaggaaaa caaaaccctg 25740 aggtgtaagg aaaataagta tgtggtctta gagtggagag tgagtagata ggaaaactgc 25800 ttcaaatttt cctaatgaca gacttagtag aaggcttgga ataatagaag aatatttaaa 25860 aagcagtaac aacaacaaca acaaaaagac tgctgctcac cccctccaaa agagagcatg 25920 ccagtgaaat ctctgacaag cataagttca agagggttat ctgaagctag acaccatgat 25980 cgtagaagga tgagttcttc ggtgtgaaga atatttattc cttggatctg tttactgttc 26040 tatttggagc tgaggcgaga gtgatgaata attgatagca ggacacccta atagtctctg 26100 taacaaaggc agaagtgctg gaattcatta catcttattg tgtgagaatc atatattgac 26160 agttacacag atgaaagagc tcccactctg tagataacaa gtctttgttc caaacgacag 26220 atttactttt ccagaagtag aagcgaagac ttgaggccta ttttgccttc cacaccttgt 26280 ctcattgatg aagtaactag attaagcctc atggaaaaca agataacaat aatggcattt 26340 ccatccttga gtcaattgaa aacaatatta tctaaagatg aaatgctgca gaatcacaaa 26400 attttaagat gataaggaat tagaatcatc tattatgttt tctaggaagt gtgccaatgg 26460 attctggccc agagtagctg cctcccaaat gccacctgac taaccaactt tcctgcaaac 26520 ctacttgtat atctgccact ttccctccct tttctacctc ctacttcctc ttctccttct 26580 tttctttcaa cagcctttat tttgtaaatg ctgaaaccaa ggccaagcaa ttgcccaagg 26640 tcgcttggca tcagaaccag gatccacatt gtccaatttc caggtttctg catttcaaat 26700 tctttattaa aagtcagaat gtgtttaatg gaatgattca ctttttttta ctgtagacat 26760 attattacag cagaccttag tttatttgtc tcaatatcag ctagtcaaag aaaaaagctt 26820 tgacattttt atgaactatt gtatcatgtt cacttagagg tttcttagga aatgaagttt 26880 agaagttagt agtcttggaa gtaagtgtca atataactga caatacaatt cactggaact 26940 catttcttct aatcctaaat aaagctaggg catggtttat taaatatttc tgtgatattt 27000 agtgtgtaaa aatgtaaaag agaatacaaa tattaaaagg aagttttcct aatgacagac 27060 ttagtagaaa tttgagtgaa ttgttaaatt tttaaagctg tgtgaacagt ggttgatagt 27120 ggataaaaaa tcattaaatc catcagtggt tttatagttt ccccagcaat aattgggaga 27180 gaatgaatga tgaaggtaaa gtgctaaccc aaagatttta gaagtttcac caagttttaa 27240 tgagcctcac caatcacccc tgatggcagt ctggtatttt acacctcctc taataaagtt 27300 ttcttcccta gttttcagtg accaccattg tgtacacaaa tatagaggag tgtacctgat 27360 cgaggaatgt atctgattct ggcaggtgga agagtacaca tttggcattc ctttttatcc 27420 atgattgtct cacctttctt tgaactgaag gttaaagtgg gttgaccatt cctgggcctg 27480 cttgggttct ggagagaagt aatctaatgt taactagaca cacacatttt ctgacttagc 27540 ctctcacctt caacatttcc aacttcctgt ctccctagtc tttgttctat ctgactttga 27600 acatgcaaat atatttccta aatttcagag ggagaataga gaggtttatt atcttcctga 27660 tggttactct gattcctgtc ccctcctttc catgtaaaaa ttcttaacaa cttttttcat 27720 cttctccttg catttgctca ccattcttca tcctcaagtt ccaggaatct ttgatttcta 27780 gccatcccag tgaaactgca ctttgaaagg tcaccagtta ctccaaggtc atctagtcct 27840 tcctgaaata cactccgggt caactctctc ttcttagctt tcttgataac gcaatgtctt 27900 ttttctccat tgctttttgg attctcactt cctgctgtct ttgaatctca attcttttat 27960 tattattgat ttctcatctg tactttaact tctcaaacct tacctgtaga actgtttctt 28020 cactcatagt gaagtacttt atatcctaat gtctaaaggt tatttcagct tcactgcaag 28080 attaacatgg ctaaaaccaa atttgtcttc tccttggaat aatcctcacc ttaaactagt 28140 cccaaaaagt cccattcctc ttggcatata ggatcagggg cttcatgtcc tttctaattt 28200 attccttgcc ttcctccttt acttaggtaa ttatcatcct gtgggtttgt gctctgaaaa 28260 gccagtctct acttttgctt tctttctgtc cacaaccctt gatctagatc ctcatcactc 28320 actagattac tgcactagcc tcctggttgt ccctgcagat gccagtctct gcatccctca 28380 gttatcttgt attaatattt aactgctagt ctaatatctc actttggctg tgttttttca 28440 ctgtgtcact tttcctcaaa tatttagggg cctctctttt ctttctgctt cctgtctaaa 28500 ttctctgctg tggtgttaag tttccagata tcccatacat tacctctagt ctgcaccctg 28560 atacttatca agcttttgaa aacatgacta gataaaatat attttatatt tcaatttagt 28620 gtgtgtgcac atgtgctcac acacacacac gtgtgctgta cactcacata atttaaacaa 28680 tttttctaaa gcaatcttta cactataatt tattctattt ctttgaaaag ataaagtaca 28740 tgagccccca tattgaattc ctgtcatgac cctatggttt gaagaggccc aatttatcta 28800 atttttttat ccctttatac ttcaccccat ccactttgtt cagaagagtc tacgcctgcc 28860 ctttaatcat gcagtgctag tttctgagtt ttcagtcata tttttctagt tcaagtttct 28920 tctaatcatg aagtcttctt tgccaacttt agctcttaaa aatacccaat tcctccaaag 28980 gataattgtg ctatgcaaga tgacccctaa tcctctgctg attttgaaat ggttttgtaa 29040 tagtaaattg tgtcttttct atctagttta taaactcatt gagaatagcc ctatgtttcc 29100 tatttttcaa actgccagat ttatgtgacg aaacaaaaat aacttagttt ccgaggccta 29160 gatacaaacc ctcgctttaa tatttttgag tcatgtgatg ttgggtaaaa tcctcagttg 29220 taaaataggg accctaaaac ttgtatcaaa aaattgccag aaggaggaaa ctagatggct 29280 catggaaacc tttggcaaac acgataccta atgagtgttt ggtgttaaat atactttctc 29340 tggcatttaa ccttttcata atgttgttta gctttctatt tgtttataat attttcaaat 29400 acaatccttt ctccagtcat ctttattgca cttttctgat tactccaatt acttgctaga 29460 cagatttttt aaaatttatg tttaaataaa atctaatgaa gaataaatgg aaaagtatgc 29520 acgccttcgg gttcctatct cacttcatag tattcaattc atgactctaa tgttctagag 29580 ggcaaaggga cataagacca gcatctataa tgtatttact ttgtagaaaa gccattcatc 29640 ataagagttg ctgccaccaa atctcaaggc tcattatgtc aaattgaatt catttaaaat 29700 gtgttattta aaaatagaaa aatttctgaa ataaaaaggg aaatattttg tgctaacttc 29760 tcatttttga ggggagcggc ctttaccata attagttttc tgaacaatta taatgtgata 29820 tgctttttta tttaatttac gaaaagaagg tttgtatttt aagataaact aggacactaa 29880 gttttagagg cacatattgc atcagatttt agaactaaat ttaaattcac ttttaacatt 29940 ctgcactgtg atatatgcag attaaaaaga aagtgacaca cataaaatca tgtctgttaa 30000 gcattttaaa atttaaaaaa tagtttttta ctcaccaagt ctcccaagag gggtactttc 30060 tggcataaat tatctaacat cagttagatg gcataaggta atgcggactg agagcagatc 30120 taaaggctaa agataggtga gaaatgcaaa tataaacata cctttcctat taatattagc 30180 tgacctctac tcaaaccaaa tgcagtataa aacatttctc tttcctattt catttggttt 30240 ctattatgtg tgttgcatgt atcctatgat gtgatgccaa attcctgacg gaatttctgc 30300 tgacacccag tccttatctt cattcacttg ttcacttttc tctccacttc agaagtgtat 30360 ccccagtgta ataaacttat tttgtatgtg taaagtataa cttctattgt tttcaattta 30420 tttgattgta aaatgaatat catattatag atgttatttg atcataaatg tatattatat 30480 taagaatagg tgaggccggg cgcggtggct cacgcctgta atcccagcac tttgggaggc 30540 cgaggcgggc ggatcacgag gtcaggagat ccagaccatc ctggctaaca tggtgaaacc 30600 ctgtctctac taaaaataca aaaaattagc tgggcgtggt ggcgggcgcc tgtagtccca 30660 gctactcggg aggctgaggc aggagaatgg cgtgaacccg ggaggcggag cttgcagtga 30720 gctgagattg cgccactgca ctccagcctg ggcgacagag cgagactccg tctcaaaaaa 30780 aaaaaaaaaa aaaaaaaaga ataggtgaga acatatgatt acaaaagaat tctgtaatct 30840 ttaaatcgat agcaactaaa attataaaaa cttttacaaa tcaatgagtt aatgttattc 30900 tagtgtcaga gtacttctgc ttctatcagt aatacggaaa atttgaaaat tatctcttgc 30960 ttatatattt actaccttta gaatatctag aaatgtttac atgagatgaa aaagttatac 31020 ttgtgttatc cttgtcctaa aagaaaaata ttttttaaaa ctttaattct tgcaagatcc 31080 aatggtctta ctctccccaa atatatttct agcaaaatgt atttctgata tttcaagtct 31140 gacatttatt ttttactaaa atgcacaatg atagttatta caggaatcaa aagtactgaa 31200 taaagcttta ccttcagtga ggttaggtta catatcaata gagcttggat attactctag 31260 gaggaagagg cagaacaata atttctaaaa tgtcattctg atatttatta gtgttgcaag 31320 ttaaaaaatg gcatcttctg aataatctaa ttcttcataa attcacatca aaagaaacaa 31380 gaagctgaag aatgttaaca gacctatgac ttaaactgat atacaatttt aatgttttta 31440 ttcagattcc ctcaagaaaa gtgtggggac agttgctggg taaatttttg tcttcaactt 31500 tctgtcttct acaatacagg gtttaataat gtcttaattc tatatcacag tatatattta 31560 atgttatgtt gtcaatgaaa ataattatct taagtcaaac caactctcag ttgaagaatc 31620 ttgaaaatga ctccatctaa attgtgactc agatttctgt ctgtaaaatt caatttttaa 31680 taggttagaa aagtctatca gtggatactg tctaatcaca aatgggtatg gaacagtctt 31740 caccctccaa accctgaagc ttgcagagaa acactggact gtacaagtta gtgctaacat 31800 gattacttat cccatccaaa attcagcagc agctgactgt tttgcacctg gaacccttct 31860 cccttttgtt ttctattgtg tagcttcttg tatttagaga ctgaaaacta attccaaaat 31920 ttctttatga aaaatataat tagtattctt ttattatatg tatatatatc tttaatatat 31980 atatgcacac acaggttgca tatgcatgtg tgtgtatggt gcattccaaa atggaagtaa 32040 actgaacaaa tagagtatca agatggtgat tcatattttc aaactccctt aaagtttgta 32100 ctccattgtt gaatttcatc tttacctagt cttaacatgt gaattgacag tttttaaatt 32160 taaaaatcac ttaaaagtta atacaaattt agtaaaaaca aaatttgaac agactatata 32220 gtatgtagtc aaaagtaacg ctttcttctg tccctttgaa gctcagtcct gctccacaga 32280 gatgaactcc tttgtgataa ctcctggtga atttccttca tactaaaaat tttgtggggt 32340 aaagactgta cccatagatc cagagccttg tgcagtgtct ggcatttatg gaacggttgg 32400 ccttcctatc ccctggttct gcctccacag agtcaactaa ctatggatca aaaatatgtt 32460 ttaaaaacaa taaaaattaa tacaaattga aaaatacagt gtaacaacta tttacatagc 32520 attacattgc attaggtttc ataagtaatc taggcatgac ttaaagaata caggagatgt 32580 gtgtaggtta tatgcaaata tcatgccatt ttatatatca gacttgagca tccatggatt 32640 ttggtatcca taggggctcc aatccctgta ccaggcattc aaggaatatt tgcagaaaaa 32700 aagaacagat aaatggatga aaagatggct gggagcggtg gctcacgcct gtaatcccag 32760 cactttggga ggccgaggtg ggtggatcat gaggtcagga gttcgagacc agcctggcca 32820 atatagtgaa acacccgtct ctactaaaaa tacaaaaatt agctgggtgt ggtggcgcat 32880 gcctgtagtc ccagctgctt gggaggctga ggcaggagaa tcgcttgaac ctgggaggcg 32940 gaggttgcag tgagccgaga ttgcgccact gcactccagt ctgggcgaca gagcaagact 33000 ccgtctcaaa aaaacaaaac aaaacaaaac aaaaaatgga tgaaaagatt ataaatagta 33060 tgtagtttca aggctcatgg tttataaact attgaaaaat cacttttcca cttcatgtca 33120 ttatttttca gcgtgcagag ggatgttaga ctgtttttca aatacaaaaa agccacaaac 33180 ttgtatcaga atctctactt cctattgaaa ttaagcccta gaggtaaata tttttagagt 33240 tttgtcttgt tgggttgttt tcttgttttt tgagacagag tcttgctcta ttgcctaggc 33300 tggagggcag tggcaccata tcggctcatt gcaacctccg cctcctgagt tcaagtgatt 33360 ctcgtacctc agcctctcca gtagctggga ctacagttgc acagcaccac acctggctaa 33420 tttgtttttt tttttttttt tttttttttt ttgtattttt agtggagatg ggttttcacc 33480 atgttggcca ggctggtctt gaactcctga tctcaagtga tccacccgcc ttggcctccc 33540 aaagtgctgg gattataggc ttgagccacc acacctagcc ttgttttttg tttgtttttg 33600 ttttttgcaa aagagtatct agtggtcatc gattgcattt tgatattata atttcttatt 33660 ttctatttca gtagtatttt tattactcta ctttctattt ctatactata gtttctattt 33720 ctattggtgg atttccttat tttaatgatt tccaacataa ctgtttaaat gcatagatta 33780 tgtagtaatc tatataatgg tcaaaccagc tagtttctgt tatactttga gttaatctag 33840 ttacaaatta tcttttttta aaaaaaaatt ccatttgacc taataaaaaa acaaaaacaa 33900 aaacaaaaaa tcactactcc ttaattccac aacttcagat ttaccgaaac cacaaattcc 33960 atttaaattt ccagtattgc tagtggtgtg gatgcctgat gtaatactga gttatcattg 34020 ccagattaga acaattttta ttgtctgaga ctactaatat tccttctgtt gctgaattta 34080 agagaatacc ctaaagcaca atgtaaattg taacactgag tagcagaatt tgagggctag 34140 aaggccaaat cattttctgt ttttttaact gtaatgacag ctattggtaa ctgcctgctc 34200 tctacccaga aattatggag ataaggaaat ctatgaatta tagtaatagt gtgtgttagt 34260 tatcattcaa aggcatttac tattttctgg cataacagaa cagagcacat agtaaaaact 34320 caataaattg taatttataa atagtatttt attatcttca tccaaaagct cctctttgaa 34380 ggtgacgtat ggagagaaaa gctgttattc ccaaaattga gttagctaag ctaagcttaa 34440 aatttatttt attttatttt tcaattttta aaatttcgat agcttttgag gtacaagtgg 34500 ttttcagtta catggatgaa ttacatagtg gtgaatctga gattttagtg cacctattac 34560 ccaagtagtg catactgtat ccaatatata gttttttacc ccacatctcc ctcccaccgt 34620 gccccctcct tagtctccaa agtccattat atcactctgt atgtctttgt gtactcataa 34680 cttaactccc acttataagt gagaacatac ggtatttggt tttccattcc tgagttactt 34740 cacgtagagt aatggcctcc agctccatcc aagttgccgt aaaagacatt atttcattcc 34800 ttttttatgt ctgagtagta ttctgtgctg tatatatacc acattttctt tttccactca 34860 ttggtgaatg ggcactgaaa cttggttcca tatctttgca attttgaatt gtgctgcaac 34920 aaacatacat gtatatgtct ttttcttata atttcttatt ttcatttgga tagatatcca 34980 gtagtggaat tgctggattg aatggtaaat ctacttttag atctttgagg aatctccata 35040 ctgttttcca tagaggttat cctaatttat attcccacca gcaatgtata agcattctcc 35100 ttttaccata tctacaccaa catctattgt tttttgactt cttaataatg gccattcttg 35160 tagcaggaag gtggtatctc attgtggttt taatttgcat ttccctgatg ataagtgata 35220 ttgagcattt tttcatatgt ttgttggcca tctgtatatc ctcttttgag aaatgtctat 35280 tcatgtcctt tgctcacttt ttgatgggat tatatttttt tcttgctgat tttttttgag 35340 ttccttatag attctggata ctagtccttt gtcagatgca tagtttgcaa atattttctc 35400 ccattcttgg gttgtctgtt tactctgata attatttctt ttgctgtgca ggaacttttt 35460 agtttaatta ggtaccattt atttattttt atttttgttg catttgcttt tggggcttta 35520 gtcatgattt ctttgcctag gtcagtgtcc aggagagttt ttccagggtt gtcctctata 35580 attttttagt ttcaagactt agatttaagt ctttgatcaa ccttgagttg atttttgttt 35640 agggtgagag atagggatcc agtttcattc ttcttcgtgt agctagccag ttttcccagc 35700 accatttatt aaataggatg tcctttcccc aacttatgtt tgtcgaagat aagttggtta 35760 taagaatttg gctttatttc tgggttctct attctgttcc attggtttat gtgtctatat 35820 cattaagatg ttattttggt aaatacggcc ttgtagtata acttgaagtc cagtaatgag 35880 gtgcttccag atgtgttctt tttgcttagg attattttgg ctatttgtct cttttttttt 35940 tttggttcca tatgaatttt aaggcttttc ttctaaatct atgaaaaatg atgtttgtat 36000 tttgatggga attgcattga ctctgtggat ggttttgggc agtatggcca ttttcacaat 36060 attgattctt ccaatccatg agcatgggat gtgtttccat ttgtttgtgt catctatgaa 36120 ttctttcagc agtgctttgt agttctactt gtacagatct ttcatctctt tggttaaata 36180 cattcctagg ttgttttttg tttgtttact ttgttttgtt ttgttgcagc tatcgtaaaa 36240 gagattaagt tcttcatttg attctcagct tggtcattgt tggtatatag cagtgctgtt 36300 gatttgtgta tattgatttt tttaacctga gactttactg aaattcattt atcaaatcta 36360 gaagtctttt ggaggcgttt gtagggtttt ctaggtatat catcagcaaa cagtgatagt 36420 ttgacgactt ctcttcttat ttggatgccc ttaatttctc ttgcctgact gctctctagg 36480 acttccagta ctatgttgaa tagaagtggt gaaagtgggc atccttgtct tgtttctgtt 36540 cttagggaga atgcttagaa tgattttata catctgtata gttccttgag acagtgaatt 36600 agaaaatttc atatttgtga atttagatat acttaatgtt tttgctcatc aactacctat 36660 tctcaagttc atagaaataa cattattcta attttactaa tggtgtcaga tatactttta 36720 ctttcaaaag tgaaattaag ttaatatgat tttaaaatac tttggagtac atttcttgat 36780 ttttttttag acaattggaa acactcaggc atgtcataat gaacaggaat agtgtacaga 36840 atgtgtcatt gtccacagat cctgtaagta aaaaatgcaa acacaagaaa agggggcact 36900 gatcatctga agtgaagttt cagccaaact ccaagtttca ataaatgttc ctgttccttt 36960 tttatgctaa atattgtact gcgaattata taccaaagta aaaactgttt gctacagtca 37020 ctcagattcc aggggtgatt ctttcattag aatgaaatat gtgccaataa ttttgactgc 37080 cagatcatta gcctatgaat aatgactttt acaaagtaaa gttctatatt atctcatgat 37140 acagtaaaaa gcatttaggc tactccacag gcaaaaatga atcatttagg ggctgtgtta 37200 ccttggggag attatacact ctaagtgtca ctttcctcat ctgtaaaata gggatgataa 37260 agttctgtga ctggagagtt aaatccaatg ttataataca ttaaaatatt tcacacaagt 37320 atttaataga tcaacaaaaa tgcctacaag tttattgtag acatgattag tttatcattg 37380 gcagctaatc cagaattact ttcaaactaa tactttttct tttgtctatt gctagtttaa 37440 tcaaagttaa ttcctcactt atggaaattg aactaaattg gaatacattt taaataatta 37500 aaatattccc cttctgaagg agtctatcga gaagtttaga ggtaaataat tttgtctgtg 37560 aataaattgg cgatctcact ggtgattgaa ttgtaacaat tatttttagc agagctagga 37620 tagcattttg ttctcaaaat agaaatcttg gggaaacctc cggacaaaag aaatggatta 37680 atgctatggt taaatgtata gagttgggct gccttttggg atggcctcct acccatatgt 37740 agctatgaga cacttgaaat gaatatccga ttagtatcac tgagaagctg aatttttaaa 37800 ttttctatta tctaaattaa aattaaataa aaaatctgaa gcataaaata tgtttgtgtt 37860 aaaaattatt atttttctta gacatcttaa tttgaaccac taaaaatttg gcttctgaat 37920 tgagatgttc tttatgtatc aaatggacat tgcattttaa agatttagta caaaaatgta 37980 atatatccca ttaataatta ctgtatattg ttacatgttg caatgttatt cttgtgggtt 38040 tattggatta gataaaatat attgtcataa tttattttgt ttatttttac atttttgcta 38100 tagctaccag aaaattaaaa ttgtacttac agcatacatt ccatttttat tggataacac 38160 tggtatagag atattgctgg agtaaatgta ctcaattctg agttgaaata ccccactgag 38220 aattaattgc aggcctcatg taagtcaagt cagacttaga atatgacccg agagagaagg 38280 tagcttttgg cagaagttta acaaaagtcg tctgctctta aagattctaa ttcagaagct 38340 aatgtggagt ttaatcctaa caactagtat ttaaaactgt tcatcagcta gagtactact 38400 aaccactttg attaatagct taggtttttc ccagcccatt tgagtattgg aaactttgat 38460 catatttgat aatattggga aattatcagt cttttctttg aaaagaaact agagttatta 38520 aaataacagg gatgttctca aactagttcc agaaccaaca ccatctgcaa cacctactaa 38580 acttactaca aatgcaaatt ttccaacctc acacaagacc tactgaatct gaaactctgg 38640 ggacaaggtc caggaatctg tggcttaaga ttcctaggtg attctgatgc acactaaagt 38700 ttgtgaacca ctatattgga atatatcata ttcttgttaa ctgatggata agatttgttc 38760 taatagactg agattttagt aagtgaacag gtatttagtt aataacaaac tccagggcca 38820 taatgatgta ctgaggctgt aaggaactca ttgaagcaca agcatggctc cctcttccaa 38880 caacttcttg cattaaatca ttagtattca ggcaggactc tagatgggga ttttccttgt 38940 gtagggtttc attattatta attgagttct taatggagtt tattgcttag cattctcaaa 39000 taacttctgt tttattgtga tacaagaaag tctaatccgc cacaatgatt ttacttttca 39060 taatggcaca gaagagttgc tgaatgtgat attagcttaa atgtatccca ctatccttca 39120 tctatttgta atgaaaaatg attctgttgc cttttgagaa catcagaatg attatgtaac 39180 atttttgtgg tgctgaatta ttttagatat gacattctta gtaaggaaaa aaaatggtgc 39240 ttcaagaaat tacttccaaa aatggtaaaa aggaatttga gaaaaaagaa attacttcag 39300 aatcttacta atttttttat tccaactttt gcttgtgtaa attaaaaata gacaattgtt 39360 gagaattgct attcctgcag ttaatttcag caccctaaat atttaagtgt aaatatttag 39420 gttaagaagg gaaatattta tgcttgaaaa agcttgtctt tttcatactt taaatcccca 39480 ctaatatctt tgttccatta ttatttattt tttagaatag cattatttta ctttatcaaa 39540 tatgcacttg ttttctaagt agttctaccc tcttcgcatt agttcggaat acatcaaata 39600 attttttctt cttttaaaaa tagagaaccc ttgtgtttac ctttccataa atataaacat 39660 ggctttaaaa aacatgaatt ttatgtaaaa tgtgaaataa atgtcaatat ttgtatgtag 39720 catttatcct ttcttacaag gagagaaaag ccagcaagag atttctgata actaccatca 39780 ccttaaagtc tgtttttcta aatactaccc cttgacaccc aataaaaaaa ctatgaaaca 39840 aataggataa gactacaaga acacaggatt acttttagtg ctctaaaggt gggagttctg 39900 caacatcata agggtgtcaa aggcctagca cattggcatt tgccattcat ggtcgacatt 39960 gatgatcatt gtgttttagc attcaaagca caaggaataa taaaagccat acaagttttt 40020 attttcatta gttttaacat gtgatattct tgtacacatg cctgaataat gcctttttaa 40080 aaacttagta atcatgcatc atatgagtgg gtaataagga aacaatattc tttaccacga 40140 gagtgggcta aacacttcaa aggacccttc atgaaacatt tggaattaga gcttgaggta 40200 ttgtgacgtt actgttttaa tcaaagcttt taagttggag atggtggatg aaaaaaacag 40260 aaaaattacc ataggtgata atagtatact caataaaaat gtaaaaattc tgccgtcgta 40320 caagactttc agtaaaaaga cctggcaaat ccccaggtat tagtggggat ttaaaatatg 40380 aaaaagaaaa gctttctttt ttaacataaa tatttcccgt ctctatttaa atatttacac 40440 ttaaatattt aaggtgctga aatcacggca gcaataacaa ttctcactta cattcatttt 40500 ctacaatgct acatctggtt atttttctat ccgggtttaa gttccttcac cataagtcct 40560 tcttcctttt ttggaaggct cagtggatgc cctatgatct gcccctggaa tactcattgt 40620 ttgttgtggt ggaaggttga taagaaatct tttatcttat aaaagataaa atgtatatat 40680 ttatattttc ttgtattcaa cagctttgaa ttggtgcacc caattctgag tagctctgtg 40740 tgtgtgtgtg tgtgtgtgtg tatgtgtgta aaacaaagta ctttataatg caaagtccct 40800 ttcttacact tccataagca ctggtaagac agcaatacag aaatacagaa aagacaagtg 40860 tataattcat gatgccctgg actttctaag gctttgaaat gcgaaccagg aacgcaaatt 40920 gttttaccaa aaatgaaaat gtcctttcgc atgacagcag tctgttccag ttgcacctgt 40980 gttttgctat gatttgcaaa ttgattggaa ttttgccctt ggtattcttt tagcctcaaa 41040 atgttctaca atttgaaaag tgtggagggg agcttgatca tatatgtact gttaaatctg 41100 attttagata aattctaatt ttatgaatat tgttttttga acaggacaat ttgagaaaat 41160 gaggattact tataaatatt tataatgatc atgaaacagt attctaaata ttaaagatct 41220 gagttgtaaa gattgatata ttaatattta ccttatcttt aaaaaatatt gcttgattat 41280 tacctatgct tcatgtggtt ccacaaggaa tatattactg ttttaacaaa gatgtatgca 41340 gttcgatagt aaaatatttt tgcaaaaatt taaagaagaa atttaaatta aatagaaaat 41400 ttagggagaa aaaattaaac acaatatagg gaccattcag accccatcat tgctatattt 41460 gagcattgaa tttggcattg aattttttca cagattaagg aaaatgtaga aagggccagt 41520 taaaaaggag aaaacatctt gtttctcaag ggaagcaaag ctttgcctac tacttaaaaa 41580 aataaaatat atttctcaag tggggcttcc cacagtgggt ttttggtaat agacacaaaa 41640 ctgaccctat tcaaacactg ctcaccaaga atatactaga attaatcata aatggccatt 41700 tagagtttgt ctagaagtgt tgcacagtaa ttagccaatc caaaatgtac agtatgtgag 41760 atgacactgg atgtctggtc ttttgcagca gatttgtaat tgctttttat tgtctatctc 41820 ccttattgaa ttgggaactc tttataggtg ggggtcgctt ttcattcata gtgttgtgcc 41880 aagtttgcac tacgcacttg ataaggaaaa aaattagtgt aaaaattgtt aaaggtctct 41940 atcagaacag tctaaggggc atttcatgat aactcaatct ttttaagata cagttttaag 42000 gcaatatttt aaaaaacatt ttgaaaggtg gatttatgaa tactgcttct ttttagaagg 42060 tgacagaatc aaacacaaac atgaggtgtt caataaatat tgctgactat attgatttga 42120 gccaaaattt caccaataat gcatttggac tgagtgtgta actaatattc ttggattagg 42180 aaaacaaagc tcttagaaaa tgaatcctag aagtttgttc aagattctgt cacctaatat 42240 gtagaaaatg tattgaagat tttgaaatat ctgtgtataa ttttctaaaa ttcatgtgta 42300 tctcctaaga atcctaccat attaatacca gttgtaatgt aggtcaaaga tgtggcaaat 42360 attttcttat atgaattttt ttcaaaagta ttagctctgt aattctttca gaaattctct 42420 gggacggcca attcacaagg aataaaatgt aaattttaaa aagccttagg gcaaactact 42480 ttcgttttct taaaatactc tgcttctagg aaggatgctt ctactaagga aaacaggaaa 42540 gtggtataag tgatctataa ctatgtatag tttacatggg acacagaagg agatagattt 42600 ttacctttgt ttttcattca ctgtaagcag ataaatgtat atttacttaa ggatggcttg 42660 aagtcatgtt acaacttcta ttactattct tgtcattgtc cacatttttc ttaattttat 42720 caagtgtgga aagagaaaaa cagaaatagt cttcctttta atttagaaat gggccactat 42780 aagcatacgc acaactcaaa attgcagttt cttaatgtta tgcacttgat taatttgtat 42840 gaattcatgc catatttctc tgaactttgc tgaattgcca ggtatatggc ttggcttgta 42900 tctccagtta taagccttgg tatagtcacg cctgactagg gcagaatgga gaacttgctt 42960 ctggcttaca gccctcctaa gggcaccatg caggttagtg ctgcccatga tgctctggtg 43020 tttggagatc tgcacacaca acctcattac cccaccttta acatctatgt cacagatcaa 43080 gggtttgcaa accatgatcc ataagccaaa agtagtccaa agatgtattt actatagtta 43140 tatttcattc ttagaatttt aaaatttaaa tgcctttgtg tctgtatcct gctataattc 43200 tggtccaacc agtccttgtt ttcttatcca gtccatgaca ctcattgata ataataactt 43260 ggttcccaaa gatatgtgaa tttttcattc ctatgaccac tcctgttttc tgtcaagtaa 43320 tgttagattt ctctgtttaa atatgaaatg ttgaaatcct aaaagctatt aataaacaga 43380 tcagttctcc caggtgactt gagtgttttc agcaagaatt accaatgcaa taatccagag 43440 atattaaaca aatggctgac tgctcaaaca ttgttggctt gacagagcat catgttgaga 43500 agatttctga gacgaaaccc aaattcacaa tgaaagactg cagtcattgg tggccataag 43560 acacgagaga caggggttgt caaacttctg tagtcccagt agatgaggat ttaccaatta 43620 tgccttgcaa caaagtgagt tatgtacttg ttgtattgcc ccaccatcct tcaaccagat 43680 tgtacttctt ctagatggac ctgcatctta aatctacgta tccttgtgac acttatttca 43740 gagctttaca aatggaaggt tatccatata attggaactg tgccagatca gaacaggaga 43800 tgttttctga gaccctcgct tctgctgcaa cattacacaa aaaagggttt agaatttaaa 43860 aaaaaaaaca agattaacca aaaacaggtt cttaaaaagt cccaggtatg gccaacaaac 43920 aaatatgaat gccacctatt ttattgtagc tacatttctc tagttgctgg tgcacaggag 43980 ttgtgattac ttgttcatat ttgcaccatg ttaaacataa tacagaagat gctccacata 44040 gctgctgtta ctaaggaaac acagagagtg cctgcccttt gaaatatttt cctgataaga 44100 aatgtgtaat gatatcacat attttgcact gtttaagaca aggtgggtag ggcataacca 44160 tagagcaatt atatcacctg aattacgagg aaagaacctc taaactagct atcgttagtg 44220 aagtacgtaa gcacactaag cttacctgag gcaggtagtt gagcgtctca ctacgtgctg 44280 aacccaacag acactggtgc cttcagtttc aatgagcagg tttttttttt acttggaaac 44340 ggtgtttgta aacagtgtgg cttgcagtct ttttttgtgc tgggtttcgt cctgatccct 44400 tacatgcatt atcacattca atcttgtcaa gagacctttg agtttcagat tgtggaagcc 44460 attttacaga taagaaaaat gaggtctata gaaactaagt aaatttccca gtgtcatgca 44520 gttgttcagt ggtagacatg aaattcagac acaggcctct gattccagtt tccatgctgt 44580 ttctttgtag tcatccattg tgtatgtaaa caacttttca tttaaacaag atgcaaataa 44640 tattggtata aaacaaatgt attctagaat ttcaactttc ctgctcattt gttccttgag 44700 cctggttttt cttgtcttca ggtttatatt ttaaggtgac atcttatact gtggtcttct 44760 ttgtttactt ttctatttcc cttcacttca caggagtaag atacccaaca tcggactgta 44820 attctgtgta cataggatgt ccatgaccct attctcctag atttgtttat agggagaata 44880 caggatgctt tcctctctga atgtaaaaat agaaccagtc agagcaaggt gttcacaagt 44940 atcttaaatt atttattgaa tcctaactat gtgtactcat atttggtatg tagctcaaga 45000 taagatgaag agaaatggtc cttgatttca agagaaggtt ttcttacata cttcagtata 45060 atcagaggag tctttggtgt cagaatctga atgcaggcaa agacctcctt tatagcttca 45120 acattcttct catttcacag gattggaact atagattttc aaagctaatt gtcagtgact 45180 atcaaagtac ggatcctgaa gatggggctc aagagctgct aggagtcaat ggggagtgcc 45240 cacaggacag acttcaccat actttaacca gagaagatac atttgaattg aatgtccttt 45300 aaaaagaggg tgtccctgaa atggaaaaaa aaatttgaac accattatag cctagattcc 45360 tcatttgttg ctgacccttc cttccatacc attttctctc ccctttcacc ataacactcc 45420 ctgaaagtat aaagtcttca acaattttat tccaatttat ccgctgaatt tggtaatgat 45480 aaaaaagatt ttaatagcaa ttgcattgcc taattactga atcatagaac attaaatcat 45540 tgacaataca caaggcaaac ctcaatatac aattaattaa tgagtctgct tgtatctatg 45600 aaatgagata cctaaaaata tagattttgt ggatacttat tcattttaaa gatattaaaa 45660 actaaagcat attcttaact actgaccaac tggtcaaata gttaagactg caatgaatag 45720 cttgaaatta aaaaaatgta gtataatttc attagctctg atatgtattt tactcaaggt 45780 catgaatcag aacttttaaa actattaaaa ttgaaggata tcaagaaata taattgatgt 45840 gtttctatgc atattaataa ggtcattttt ccatgtcaaa ttcttctgag tcttaaacta 45900 tgttatagtt tgaagttagg cttttttgga aggcattgtc gtatattact aatgggaatg 45960 cataaattat acaataaaaa ttggcttagt aagcctaatt aatagagcaa cttcaggtaa 46020 ttcaatcaag taaaacttgt ctgagacttt cttttactat atgagcaata ggaataggtt 46080 ttagagtata agtgtcttta agaacatgta taagagaaaa agagaaagag taaacattaa 46140 aaggacagtg attgttaaat atttgcagaa gtttttctgg tagttaatgt ataagtacta 46200 agtgaatata cagaagccac agctctaata gtttctccaa tgttttagca tctttttcta 46260 gcccaggact gagttgagtt ctttttagga gaaaagcgtt gatgccatct gcagcacacc 46320 tatagatcat aggcaagaac aagaagtaga ttgcatgctc agttatcagg tatacgatac 46380 atctgagtta gttcctggca tgtaaatgat caactccctc tttccctttc cttttccttt 46440 tcctcttcct tccttccttc cttctctccc tcctgccctt ccttccttcc ttctttgttt 46500 tcctttcatg ttttgacttt actatcaagt tctagccagt atgcagacta ttttttttaa 46560 gttctgaaaa tattcttgca aatttctaaa tgagaaacag gtaaatttta tttatttttt 46620 tcagctttcc tgaggaataa ttgacaagta aatattgtat atatttaagt tgtgagatgt 46680 gatgtattga tacatgtata cattgtgaag taatcaccac aatcaattaa catacctact 46740 acctcacata gttacctttt tttgtggtga gaacatttag gatctattct cttagcaaat 46800 ttcaagtaca caacacaaca ctgttaacaa cagttccatc ctgtacatta tatttacatg 46860 taaggcaaaa tgaactctaa gttaaaaaat aaacagaaaa taaaaaatag atctccagag 46920 cttttctctc ctgaataact gaaactttct accatttgac caacatcact ccattcctcc 46980 caatccctgt tccctggcaa ccactattct actctctact tctatgaact tgattttttt 47040 ttagataatt attacattga atctgtagat agctttgagt agaatggaca ttttaacaat 47100 attaactttc caatccatga atgtgggata tctttccatt tatctgtgtt ttatagtttt 47160 cagtatatag atctttttac ctctttggtt aaatttattt ctaaattttg tttatgttat 47220 tataaaatga attgatttct taatcttttt ttttaacttt tattttaagt tgaggggtac 47280 atgtgcaggt ttgctatata ggtaaacttg tttcatcggg gtttattgta caaattattt 47340 catcacccag gtattaagcc tagtacacat tagtaatttt tgctgatccc ctccctcctc 47400 ctacaccaca ccctccaata ggtcccagtg tgtgttgttc ccctctaggt gtccatgtgt 47460 tcccataatt tagctcccac ttctaagtga gaacatatgg tatttagttt tctgtccctg 47520 tgctagtttg ttaaggataa tggcctccag ctccacctat gtccttgcaa cgtacgtgat 47580 ctcattcctt tttatggctg catagtattc catggtgtat atgtaccaca ttgggtaaat 47640 aataaaatta aggcagaatc aaaaagttgt tcaaaactag taagaacaaa gatacaacat 47700 accagaatct ctgggacaca gctaaggcag tattaagagg aaaatttata agattaaatt 47760 cccatatcaa aaagttagaa agctctcaag ttaacaacct aacatcacaa ctgaaagaac 47820 tagacaacta agagcaaaca aatcccaagc tagtagacca caagaaataa ccaaaatcag 47880 agctgaactg aaggagattg agacacacac acacacacac acacacacac acaccattca 47940 aaagatcaac aaatccagga gctgggtttt ttttgaaaaa aaaaaaaaat aagctgcttg 48000 ttagactaat aaagaagaaa agagagaaga ttcaaataaa cgcaaagggg atcagaaaca 48060 acaaagggga cattaccact gaccctatag aaatataaac aaccaccaga taatattata 48120 aacacctcta tgcacataaa ctagaaaatt tagaagaaat ggataatttc ctggacacac 48180 atacactcta agactgagcc aggaagaatt cgaatccctg aacagaccaa taataagctc 48240 tgaaattgag tcagtattaa atagcttact aaccaaaaaa agccagggcc agatggattc 48300 acaaatgaat tctgccagat gtatgaagaa gagctggcaa tattcctgct gaaactattc 48360 caaaaaaatt gaggaggagg gactcctccc taactcattc tatgacccag tatcattgtg 48420 ataccaaaac cttgcataaa tacaacaaaa aagaaaactt caggccaata tccttgatga 48480 acattgatgc aaaaatcctc aacaaaatac tggcaaacca aatccagcag cacatcaaaa 48540 agcttatcca ccatgatcaa ataggcttta tccctgggat gcaagtttgg ttcaacataa 48600 ctaaatcaat aaatgtgata cataacataa acagaactga agacacaaac cacatgatta 48660 tctcaataga tgcagaaaag actttcagta aaattcagca ccccttcatg ttaaaaaaaa 48720 aactcgataa attaggtatt gaaggaatat acttcaatat aataagagcc atctatggca 48780 aacccacatt cagcatcata ctgaatgggc aaaaactgga agtattcccc ctgaaaactg 48840 gcacaagaca aggatgccct ctctcactaa tcctattcaa catagcattg gaagtcctgg 48900 ctagggcaat cagccaaggg aaagaagtaa aggacatcca aataggaaga gaagaattca 48960 aactatccct ctttgcagat gacatgatcc aatatctaga aaaccccata gtctcagccc 49020 aaaagcttct taagctgata agcaacttca gcaaggtctc gggatacaaa atcaatgtgc 49080 aaaaatcact agcattccta tacaccaaca atcaagctga gagccaaatc aggaatgtaa 49140 tctcattcac aattgccaca aaaagaataa aatactagga atacagataa gtagggaggt 49200 taaagatccc tacaaggaga accacaaaac actgctcaaa gaaatcagag gtgacacaaa 49260 cagatagaaa aacattttgt gctcatggat aagaagaaac aatattgtaa aaatggccat 49320 actgcccaaa gcaatttaga aattcaatag tattcctatt aaactaccat tgacattctt 49380 cacagaacta ggaaaaaaaa cctattttta aaattcataa gaaacaacaa caacaaaaag 49440 cccaaataga caaggcaatc ctaagcaaaa agaacaaagc tggaggcatc atgctacctg 49500 acttaatttc ttttctggat agtttgttgt tagtgtattg aaatgcaact gatttttgtc 49560 tgttgacttt tttattctga aacttcacta aattaggttt taacagattt gttggtatag 49620 tctttagggt gttctttata taagataatg ccatctgcga gtagagacaa tttaacttct 49680 tcccttcaaa tgaagatgct ttttatttct tttccttgcc taatattttc agctaagatt 49740 tcaagtacta tgttgaatac caagtggtga gaatgggcat cctggtctta gagaaaaagt 49800 tttcagcatt tcgccattga gtatgatttc aactgtggat atgttatata tggccttttt 49860 aatgttgaaa tacatttttt ctttatctaa tttgttgagt ttttattatg aaagagttgt 49920 gaattgtgtc aaatgccttt tatgcatata ttaagatgat catatgattt ttatccttca 49980 ttctgttaat gaagtgtatc acaatttttg atttgtgtat gttgagccgt cctttcctcc 50040 caagtgtaaa tctcactttc ctatgatgaa tgatcctctt aatgtgctgt tccattcagt 50100 ttgctagtat tttggtgagg atttttgcat ctatgtttat tggggatatt ggcttataat 50160 ctttttcttg tagtgtcctt gcctggcttt ggtatcagga tagtgctgac cttgtaaaat 50220 gagtttgtaa gtgttttctc tttaattttt tggaagagtt tgagaagaat tagtattaat 50280 ttttttcaga ggtttggtag aattcaccag agaagccatt agtgtctgca tttttctttg 50340 atgagagatt tgtgattact gcttcaactt tatttcttct gattagttat tattctgttt 50400 taattttctt tttctttatg attcagtctt agtaggtgtg tctttctaga aacttatcca 50460 tttcttctcg gttatccaat ttgttggtga attattatac aaatagtatc ctgtaattct 50520 ttatattcct gtgatatcag tggttatgct tcctttttca tttatgattt tatttaagtc 50580 atctcttttt tcttagataa tctagttaaa gttttgtcaa tgttgtttat cttcttaaaa 50640 aaacaactcc tatttttatt gatcttatct attgttctct agtctttatt ttatctctgt 50700 tctaatatag tttgattttt ttctgttaat gtttggctta attttgtttt ggtgttttct 50760 tctagttcct taaggtgtaa agttaggttg cttatttgag atcttttctt aatataggtg 50820 ttcattgcta taaaattacc tcttagaact ggttttgcta tatcccataa gatttgatat 50880 gttgtgtttc atttttgtct caagatattt ttctcttttg ctttcttctc tgatttattg 50940 gatattcagg ggtatgttgt ttaattccaa catttttttt aagttttcta attttcttcc 51000 tgttattgtt ttctaatttc ataccattct gttcatgaaa gatcctagac atgatttcaa 51060 ccttcttgaa tttggtaaat cttgttttgt ggcctaatct atgatcctgg ataacattct 51120 atgtgtgcta gagaagaaca tgtattccgc tgtggttgaa tggaatggtt tatatacgtc 51180 cgttaggttc atttggtcta tagtgttgtt caagtccaat gtttacttat tgatttttct 51240 acctggatga tctgtttatt gttgaaagtg ggttattaaa gtcttctact attattgtat 51300 tgctgtttac ttctcccttc agttatatca atttttgctt tatatactta gatgcttcaa 51360 tagatattgt atatctatta gcaaatgatg atggccatat taattttaat agtcttgtac 51420 ttttaacttt tatattaaag tcaaacatga tctacacacc accatcacag tattagaata 51480 ttctgaattt gattatgttc ttatttactg tgagtttaat attttcatgt tgttagtttg 51540 cttttgtttt aacttgaaga agtcacttta gcatttttgt aaggcaacta tagtgattaa 51600 ctccctcagt ctttgtttgg gaaagtatct ctcatttttg aggaaacctt tgctaggtac 51660 agtattctca gttgacagtt ttggattttt tttttttttt ttttttttta accagtacct 51720 gactatatca tcccatcatc ttctggcatc aaggtttctg ctgagaaatc ttctgatagt 51780 cttattgtgg tttccttgta tgttataggt tgcttttcta ttgctaattt ataatcctct 51840 gtttgtcttt gacttttgag aatttgactg taatatgtct cagtgacgat ctctttatgt 51900 ttgatctatt tggggtaatt tacattttat gaatgtagat attcatctcc ttctccatat 51960 ttagagtttt ctgtcattat ttcttttaag aatccctctg cctatttctt ttttttagtt 52020 tgtttcttct tggacttaaa taatacataa ttggttcact tgatggtctc ccatagccct 52080 gcaggctttc ttccctcttt ttctttattt ctttttattt ttgtttctcc aattaggtca 52140 tttcaaatga cctgtctttg agtttgctaa ttctttcttc tgctttatca agtctcctac 52200 tgaagctctt taaagaattt taaatcttat ctattgtgtt cttcagctcc agaatttttg 52260 attggttctt ttatatggtt cctgtctctt tgttgaactt ttaattttgt tttttattgt 52320 tctcctgatt tttatttcag gtagtggtgt tctcttgtag cttattgaac ttcttcaaaa 52380 tgattacaga tggttctcaa cttatgatgg ggttatgtcc tggtaaaact atcataagtc 52440 aaaactgcat ttaatatctc aatcaattgt aaagtaaaaa agtcataagt caaccatcat 52500 aaatcagaga ctgtttgtat ttttaattat tgccacacag ttcatggatt ttcatttctt 52560 taggataggc tatggatgct ttattttttt ttctttgttg gtgtcatgat tccatgatta 52620 taagcaatcc ttttggtctc cccttggtat cttatcattt gaagaattag ggtcctcctc 52680 tactctttac atattgtatt tggcaaagaa agcacttcac cagtcagcct ttccaaagag 52740 tctaggtaga taggctgaag tatctgcaga taaccttgct gctggagtcc ttaggtggct 52800 ggcctggtgc caaggtcagc aagcacgtgg gcctggagcc ttggttcact ggagtaggcc 52860 tggaactagg gtcattgtgg gtggtcctgg agcctgtgag tctgtgggtc tgtggatgcc 52920 agcctgacac cagggtctac tgagatggac ctggaaactg agtatatagc atctgaactg 52980 atgttatctg ggccttgagt ctgagtcagt gggggccggg ctggtcctgg gccaggcctg 53040 ctgccttgat ccatgggaaa gacttgatca tgagtctgtg gaactagcca ggcactgcag 53100 tctactgcgg tagtgctggc acctgaatac agagggatgg gcctgatgtc tgtgattatg 53160 tgtgtggacc tgggtccaag atccatgagt agcagcctca agcctgaatt cgtggatgcc 53220 agcctggtgc tcagggccac agaggctggc ctggcaccgg gttggtcctg gatcctgggg 53280 ctataggagc cagcctagag cctggagcca ctgagtctgg tgttgcactg gagtgggcct 53340 agagcctggg ttcatggtgc cagcctagaa cctgggtctg caggagccag cttgacacta 53400 aggtgagtct ggagcctgag tctggggagt gagcttgagt tctgggtctg tgggcactga 53460 cctgggatct gaatccatgg aggatatcct acacatggat cctaaatcca catgtgccag 53520 cctggagact gggactgccc aggccagctt gaaactaggg caggcctact gcttgggtct 53580 gcagggccta gcctggcacc agggttaact ggagaaggcc tgatactggg gttcactatg 53640 aactcattgc tcgatccatt cttctcccca catgctaaag gtatcattct ccatgttgtg 53700 ctgcatggtt ttcggggaag gttgatgcag gtaatataaa actgtcctcc ttaccatctg 53760 ctgtgcatct tttcttattc tcgtgcttcg ctcaagtgct gtaatctttc acctgcattc 53820 cttagagcat ggtaaggtat tttctggtgc ggatggttgt tcaaatggat atttttgtga 53880 agggaaactc ctattccacc atgttgctga tgatacccct cttcttattt atttattttt 53940 aaatcatgca gcttaaaata ctgaacatct ggatacctcc ccaaatcaac ataggtcatg 54000 ttcagtaaat ttaagcatgc ttgtgttaga cagcagctta catttagaat tttttttaat 54060 tgaagacata attttaaaat actttgcttt aaatacattg aaactttttg aaacattttc 54120 aaagatatta caccaacatt tatttaaaca gaatctataa aaatcatatg cattttaaaa 54180 tttgtttggt ttataataga agtacaagct caaaaagtcg cattcccagg gtccaatatc 54240 tggcttggtg acttgcttat tgtgtggctt tggacaattg gcttacctct gtgcatgttc 54300 tcttatctgt aggatagggg taattgtagc tacataatgg agtttaagta aggaggggtt 54360 gacataggtc aagctcatga aacagtagct ggcacacagt aagtgttcca agaatgttgg 54420 ctcatactac tagctttttt tttttttttt ttttgagacg gattctcact ctattgccca 54480 ggctggagtg cactggtgtg atctcggctc actgcagctt ccacctccct ggttcaagca 54540 attcccctgc ctcagccccc tgagtagctg ggattacagg cacacaccac catgcccagg 54600 tgattttttt gcatttttat tagagatggg gtttcacaat gttggtcagg ctggtcttga 54660 actgctaacc ttgtgatctg cccagcttgg cctcccaaag tactgggatt acaggcatga 54720 gccaccgcgc ccagcccata ctactagttt taactcaagt ttgtcaaacc attgaaaggg 54780 agagtttatt aaataatttg aaaaattaat tgtctaataa gagtggtaca gttacaattc 54840 agtgtccatt ctcaggagat gctaagtagc actggtcata gactcttgcc tgaaaaagtt 54900 gcccctaaaa accacacagt caaaacagcc aacaagcaac aacaacaaaa acaaaacaaa 54960 aatgcacccc aactgcaaac aaacaaaaaa caaaaaacaa aaaactattc cacaggcagc 55020 ctgatatgga gtaatagtgc aaaacaggag aaaataaaat ccaaaacaca gaaagccttc 55080 ctttttaatt cactcatttg aatatttaaa gcaagttaga tttgagtgac tgcaaaaaaa 55140 aaatacagtg aagaaaatca agacagccca atagtcgcaa attattataa aaaagtaaag 55200 tcagtgaaat gttgtaaaac ttccgatgta aaatattaag tggtcatgat atagtaacac 55260 taatacttag caagaactat aatgatagaa tagaaagaaa caaatagaaa agtaagagct 55320 ttattaaagt gttatattta agactgtcaa tcttaaggac agatattgct aactggtgta 55380 tttagctaaa tgtgattcat atcagtcaaa aagactgatg tctcttggtt tatcctgttt 55440 gatgacaagc taatattttc tttcaaaagt gaaatatatg tatagttaac aacattttaa 55500 gttgattctt aaaactaaat tggaaatagt acggacctat ctttgaatag aaaagaccat 55560 ccttattggg ctcatgtcag ctttcactgg cagattgaga gttccagttg tcagaggtct 55620 aaggaattat gactccctcc aaaacagctc catgactgct cccttttcct catccttcat 55680 accctcatgg tctggtcata atttctgtgg aggttaacca ggagttaaaa agcattacaa 55740 cccctgctag tgtagaatta actctatcat aaattaaatg tttctaaaat attattgtgg 55800 ctagtatggg ataattttgt caaagattcc ttttaccatt aaatatttgc tgaaattttc 55860 caaaacaata gtgtatccaa agtagtgcta ccttctaaga tctttaggaa aggaagggaa 55920 tctaacactc atgtaatatc ttactccatt tgatccttac cgcaattctg taggcgaagt 55980 aatcttgctt tatttgtgga tgaagacaat gaaactcaga gagacatttg tccaaatttg 56040 ccaagtttgc aggtggtggt tcttgaacct ggagttctct ggcttaaggt ctttccacta 56100 cttgatgaaa ttagggaaaa aaaagaaaat ttaacataaa accacttaac acgaagttaa 56160 ttcttcagtg ctcatatcaa tgactatata gttagttata ggtgaattaa tacatctctg 56220 gtaaggatta aataataaaa tattggggtc aatattatta tttctatacc taacatgaca 56280 gaggttgaag gaaggaacag tagtggtcaa tatgccaggg tccacactgt aaatcagcca 56340 gctactgtct ctgaggaagt ggtcaaatta tttaacccat tggagcctcc atgttatata 56400 aaagcagccc acaggatggt catgaagatt aaataaaaca atgtgatagg gaatgttgaa 56460 catacatcag ctcaataaat cattgctgat tttgaaacaa tagtattaag tagcatattt 56520 ttttttcatt tttagtttgc tgaagacttc cactgctctt ctacaggcag tctgtatttt 56580 acaaaatcca aatactatat tataaaaaat atataaattc agactaaatg ggagttctgc 56640 ataaatgaaa gtcatgagaa ttcctgaaac ttgttttttt aaaggatatc aacatatatt 56700 ttattcagac atctagtaat tagctctttg aactgcaact agagtggact caatacattt 56760 ataaaggaga aatcttgaag tcaggaatca ccagagaata agcagacatt tttttacatt 56820 tcaaatggaa acatccagaa atattctctt taatataggt ttcttatgtt cgaagctcag 56880 gtattaaaga tggaaactat gttgagtttt aatgacatct ttttgtattc atcatcttag 56940 agatgttgtc tctagaggat actgctaaaa ggattggcaa aataaattta agagagaata 57000 tttaatcagt ctagtctcac attgtctttc cttcagcgag tgtttgctga ggcatcagac 57060 tagcaaatat atctttgtca acatctgctc tcattttcca aattgacagc attcggaagc 57120 agaagttggg attaaatgtt attcttaaac cttggatcaa gctataaaac cacattccgt 57180 ctgctacaga aaagccttcc tgaaaacatc tcaaaacatt gttggcctga gccaaacatg 57240 tcctacaaag gatgtaagtt tgttttccaa ttttccaggc ttgccaatat tttccaagtt 57300 tatcaaatgt tgaagcaaat ggatgttttt ctgcaaatgc actatttcag gcaggtccaa 57360 gcagggggag tcactaatga gtgtcatggg ataaggaatt tattatcaca attatatctt 57420 acacaactgt ggaaggggac atgaaaatga agcccaacta ttatcatagt tggattgtca 57480 gaaaagcagt ctaagaaacc aagcagatcc agctaccaga tgggtctgcc aaggaaagct 57540 tgtagagacg tctgtaggaa actgttgctt ctgatatgtt attacctttg tggctccaca 57600 gtgaaagact ttgtggtggg cctagccact gttggataac agaaagatgc tggatgcata 57660 gtgaagagtt aggacaggct aggacccacc aggtgtctct gcatctgtcc atcacagcat 57720 ctgactgtga tgaccctcag agactaattg ctactcaact actccacttt cacctcccca 57780 atctcacata tgctgctctt attgtcaact tataataatt tgaaggggag gagatttcga 57840 gaaacatgat ttccagctta accagatata cagtgctcca tcctacaggc tattgatgcc 57900 tgttccatgg atggccttgg tgaggatgct tcagcgtccc tttgaagcta tttaacttta 57960 ttttcagaat agtgcaacag aaacatgctc agaatcattg cttttcttga tactcagatg 58020 ttttctcttc ttcattaaat ctctctggtg gctctgtttc tatcctcatt attaaagcca 58080 aagttcttac aatgacccac gaagtttgaa ggttggactc tttatttggt ctctggtctt 58140 gtctcccaaa cttttctctc tccttccctc agctccagcc acactggcct tctcattgtt 58200 ccttgaaaat gtcagacatg ctctgctgta gtgcctgtgc acttgctgtt cctggaatgc 58260 ctttctccaa aatagccaca tgactcattc catcaccttt ttctggtctt tcttcaaatg 58320 tcgacttctc agaaaagcct ttcatgacaa ttttatttaa aactgtgccc cttacttcct 58380 cttcaccctt cctgttttat ttttttccat tgtccttttc attatctacg tacaatatat 58440 tacatatgta ttttgtgtgc tatcttttct cgcatactag gacataagtt cagtaagcag 58500 agagaatttc atctgttttg tttactgcca tgtatggcat atgagggtgg acaaaagcca 58560 gtagcaatgt tacaagtatg tgttgaatgt atttaataaa atagagttac aaaatcattt 58620 gatctattta taagaattat gcatgggttt tgtgtcatga atgcaaggtc taattttaaa 58680 tgccatattt caaaattaat aacactagaa aaacctaaat tccagtcagt ttttcatcgt 58740 gattttcatc tcaccagtga ggagacctgc aatgtgaaga aatattcatt gaatttatcc 58800 agcttcataa tttcttttgt gcagggtatt gaaatagtcg gtcactaaag caaattttct 58860 cagacatttt aagcaatgtg ttctctgctt gaagtcttga attaatcatt ttctaactga 58920 ccccctgaaa cattaaggat tgagcttagt gacttgaagg aaagacagtt taaaaccaag 58980 tatctagatt tatttgctaa tttcttacat gtcaatatgt agacactaat ctttaaggac 59040 cccatgctca aaaaagtata atatatgtaa tgaaatccaa aaacaccttt acttacttac 59100 cacatcactg ctgtctcccc tgttactact ttcatttttt ttcaactttc aatctaattt 59160 ttaccttcct cattctcttc cactaggtgt atttgttttc attctcttag attatcagaa 59220 tatgcataaa taaagttgaa agccaataaa catagggatt tggttaataa acatagggat 59280 ttaataaaca tgtaaatgaa tgttaataaa caacctgaag aattcagtct ctggccttat 59340 tgcttactgc agcctgacat tgtgaatttt tttttatttc tcttagtttc atctgttaaa 59400 ctaaaaaaaa aattaataat aatagatgct atcaaatgag gcttttatgg ggatgagatg 59460 agctaataca tacaaaacat ttagcacaat gctgaagaca aaatgcaaac tgaattcatg 59520 ttattatcaa tatcattatt tataagtgtg aatatacact tggtatataa tacttcaaac 59580 ctctggttct cagtttcctc agaaatataa ttaaaaatta aaatagagta tctttaatct 59640 ccatttcagc tataaaattc tgattctata caatatagat tggatatgta aatggccata 59700 tttggatata tacaatagga tataatctct agtgaattat ctcttaaatt aaacaatgat 59760 ggcaatttaa cgttatatca ttttaccagt ttattacagt cttttaatgt gacagctgtt 59820 ccaaccttaa aagggatcaa atcatactct aaacagtata cttttcgaat tgagtaattt 59880 ttgtttagaa accagtcaaa ataatgtcta ctgcaagaaa tctcatactt ataagtacat 59940 tctatcctaa aagttgttga gtcgattgtt tggaactcta acacatttta cacgtaacta 60000 actttacata aggttagaca tgggggctgt gtgtctccat gcttgagaaa aaattagttc 60060 aattaggaaa atataagagg gtaaataaaa acgattttgc agagtctaaa agttgtgttt 60120 ggacattgtc acaaaacgta gggcactggg ttgttatctt taataatatt ttctgcccct 60180 acccttagaa ctcaaggatt ctgtttctag atattgattg tacaactacc ctagcactgg 60240 ctggcacgct gttattcagt gcatcacttt ttgtagtggt agtaaatgat taggaaaaaa 60300 tccctacaaa tgcttcagta gagaatgtgt tgcataaatg acacaatcat gcagtaaaat 60360 acaatgcagc ccttaaaaaa gaatgagata tacttttgtg tacttacctg aaaacatcac 60420 taagatatat catcgaggaa atgaaaggag atgcagaaag ctttgagtaa taggctacag 60480 tttttttgtg gaggaaaata acatctttat gcctgtgtct gtggattact actgactatt 60540 tttaccttta aggaagggaa ttacttttct ggcaacaagg aagagagaca agaagaattt 60600 tgttcttctt tatcaaattc ataattcata agcaaatgat ttaactttgt attttccacc 60660 tccttgaatc catttgcacc actaacattc ttgctatacc aattgatcat gcattagaaa 60720 gtttttgtta aaactcaatt gcagcagact aagggagaaa acacacatgt accttgagga 60780 agtggaggca attgagaggg ggaaaagtaa gaggatttaa aaggatgtct gaacacatgc 60840 aagagagaga ttaattaaag tgagataatt actgtgtcca gtggttatgt acaatgacac 60900 ggagttgagc aaaattattc tgagagggaa gagaccatga gggagcgtgg ttggctcaga 60960 cagtgtacta ccaccaggtg acgttatcaa cccaagacag tttggatgct gttataagtg 61020 gggtaccaaa agggggataa aaatgaaatg gcatttggat taaaaagtgg aaagaagtgt 61080 gtgagcaact attcagaagt tataacaaga agtacatata acaacttagc tcttacagga 61140 taggaaagag tataatattg tgtgcacgcg tataaaaaga tgtatataaa tttttaaggg 61200 ctggacatgg tggctcacgc ctgtaattcc agcactttgg gaggctgagg caggtggatc 61260 atgaggtcaa gagatcgaga ccatcctggc caacatggtg aaaccccgtc tctactaaaa 61320 atacaaaaat tagctgggct tggtggcaca tgcctgtagt cccaactact caggaggctg 61380 aggtgagaga atcacttgaa cctgggaggt ggaggttgca gtgagccgag attacgccac 61440 tgtactccag cctgggcaac agagcaagac tctgtctcaa aaacaaacaa acaaacaaac 61500 aaaaaaaaca aaaaaaaatt aagactggct taaatgctgt cgtttttctt aaggtgaaag 61560 ctctcctaca acttttggaa aaaatacttt ttgccataat ttttgccaac aaaactaaac 61620 aaattaaact gaatattata acagttgata agtaattaaa attacaataa agtttttttt 61680 ggatttcact aaaattgcgt ttgaatgacc taggcagatg aacccctcag aaagacaaaa 61740 aaaaaaaaaa aagaatttgt tcctctccac taaagggtgt agactcaatg ggtcaataat 61800 tggccaagta gtaaatgcgt ataactcaat gaataaattt actgtaagta gacacaggtc 61860 agttctattt cagaatatca tgctatgcag tgatgtctga tagtatgtac attagtttaa 61920 aatgaaaata tctaaaatat cagtttcata atgaggtaaa tgtgaatcac acccatttat 61980 tctctatcat ctctttttgt gtgatttaat aattgtaaaa agtattaaaa tcacatgata 62040 aaatatactt ttgatattta ttgcatatag tgaagaacct tgtgagatta tttattcaag 62100 aacattcaat gcttatctac cgtgtgccag gttctgtgca ggcactgata ataagatcag 62160 gaaaaatata catagttctg cccctcacag tgtagagtaa tgagaagata aaggatttga 62220 atttagactt gtctggtaac ccaagacgct gtttatagat tgcattactt gacagtttaa 62280 tgagcttctc taattctcca tttattcaaa atatatttat ggagactctc ccatctgcct 62340 actacaattt aagatggtgg acaaacagaa atgaataaaa caggtaaaaa tccttaacct 62400 taagagactg acatatcaat ttctttatca gataaataat ataatatcaa cttcattgta 62460 acaaagatga aatgaaaaaa tgtatatata gagcactgag attagttcta gaaaataaat 62520 tgacttccaa taaagagaaa ttcccatttt cctttgattt atggctcttt agacaatttt 62580 ttctacaaag cctcattttt ttagaaagaa ggatctctgt ttttcccatc tttgtattca 62640 agataggaac ttaaatttta ttgaattgct attatttgga gaatcattca tttaccacac 62700 gcatgccaaa aagtgtcacc atattggaca aagttagcct ttttaaaaaa acaaatgata 62760 ataaccagtc ttataaatta tataaaatct gcttcaactt attacattca atgtgataat 62820 gcaattactg ttagttcaat ttatatcaat agtttgcctt gtttcacaca agggaccaaa 62880 taaaatacat agtattctct ttcttatggc atagtcagag tcatgtattt taaccttgat 62940 tgaaatcttg gccctgttac ttgccataag gctgttggta agtgcttcac tttgctgggt 63000 ctttctgttt tcttctttgt ataatgagga tgattaaaac ctcacaaggt tgttaggaga 63060 ataaaatgag atactgtaat acagtgagta tatgtaaagc acttagcata gtgcttggct 63120 tatataggag atgctcaaca tatattcgtc tcctcaactt caatatttac tcttacactt 63180 ttactaccat aagtagaaag tacagtcagc actctgtatc agtgggttct gcatccatgg 63240 attcaaccaa ctgcagatca aaaatattga caataaaaag aatgtgtctg tactaaacat 63300 gtacagactt ttgctcttgt catcattccc taagcaatac catataacaa ttattgatat 63360 ggcatttaca ttgtattcag tattataagt aatgtagaga tgatgtgaag taaacagcag 63420 gatatgccta ggtcatgtgt aaatattttg tcatttaata aagaacttga gtatgcttgg 63480 attttggtta tctgtggggg ttcctggaac caatcttcca tggataccga gttatgtctg 63540 tactatactg gtggtacttg tcaaacagca gaataatcct agggattcca ggaaaccctt 63600 taggaatttt ggaacacttc tctcagagtt tctattgatg ttaaatcaca gcctttatgt 63660 actagtcaaa gatggtgaat gggcactgaa ctccaagtac caactctagt aacaaagaat 63720 tgagaacagg gaaagagtga agaagaacta aaagttgtta gagggcttat atatgaaact 63780 tcttatagtc taagaacact ggtctcatga ccaatctcta cccaagccag aaagttactt 63840 catgttcatc ttctctacat tactccagtt aaagctccat ggggaatgag aagcagaaat 63900 atacctaata tctcaggtaa aaatgagtgg gagaagagca gatattataa agatatgaga 63960 gaaaatccca ttgcctttta agattatgga atgcagtaca gtcaggtccc ctggaaggga 64020 aattaggaat cataaagtcc tagactgagc tactgtctct tttagagact acatgatctg 64080 aagctctttc ctctcttccc tctcccaatg catctcctta atagctcctc tttctccttt 64140 ctctccttct ctttctttct cttgtcctct cccttccctt cctttctcca atgcatcttt 64200 ctcctctctt tttgtctgtc tctaccacta ttttttgact tatatttggc ccaaaataca 64260 gtcttcaaat caatatgtct tttcagctga acacccaaaa gataaccaat tcagtcttgc 64320 actattttaa ctacacttaa cagagagaaa ctgatttggc ccagatcgtt tgtattggcc 64380 aatgattggc ctccctcgac ttgaagatga gcacatgggg ttgtgtacat gtaatactta 64440 catgaagcct cccatccaga ggctacatgt aggtagagaa ggttcactag gaagggatca 64500 tttatattcc tagcaccaca caatggatgt ggaatgtagt atgtacttga taaatacctg 64560 ctaaataaat gagagaacgg tatattcata gcttattttt gtaaatgtgt actcttttca 64620 tactttacta gctttactaa taattgacag ccaatatgtg tggactgctt atgagccaga 64680 tgttgtttca tgcacagtcc atgtattcac tctgtaatcc tcacaatatt cctatgagaa 64740 aaccaggcat agattgctta aataacttgc ccaagtttac atagctagta aagagcagag 64800 ccaaggcatg tgcctaggta ctttaaaact ggcatccaca ctgttgatct gtatgctgaa 64860 tccactctca acatgcactt tattctacac agtatagagc aagtctatat tcacttatgc 64920 cactatggat attttagcat tttgtagtag ttattattaa aaacaagaaa atgaaattgt 64980 atagcagcaa cttaatggac atcaaggagg tcaaagagtt ttctggtaca caatgcaaat 65040 gaatgcctaa aaagtataat catcttggtc ctaaaaatct attagttttt ttccttttct 65100 ttgcattctc tggttatata gctctacatt ctttcctttt ataatcagtt ttttactttg 65160 attattcatt ttatccatat ccatttgact tttaaatgtg atggctactc ttttaaaagc 65220 atcatttaca ctcaatttct attccgtagc cccaaaccac aactcatcaa tgcctcctca 65280 aagggtaaca tgtgagtaga aagagaagca tggtagacaa taagaggaaa gtattttgtg 65340 caacaaagaa caagtcacaa tggcagtgta atttctaaaa ttcaaataca ttatgtataa 65400 tacaaagata atgaaatgaa aagtacaata tagttcaaat taaaactaga ctcactgtta 65460 aagaaacaca gactaacaca atcagataat ttttttttac taaactagtt catttttttg 65520 aaaagataat attccctgat atagagaagg catgcagtag gagagtagtg tatttctagc 65580 aaacaatatg gttatatgta ttaagagctt tcgaatgttc attcactcct ctttcaaaaa 65640 ttatattcaa aaaaattatt tcaagggtca cataaatttg tgtacaatgc tgctcatcac 65700 tgttttattt atacaaatta acatcttgta atttaaatga tccatgagag aatattaagt 65760 tacagattgt acatataaaa tattgtgcta ctattaaagt gtctatagaa aattaatatc 65820 attattaatt gcccttgaag tgatgcctat aaaattattc caggaaacaa gtgtggatgc 65880 atacacattc gtaaacaaag gagactcgaa agacaccaaa atatttataa tcattatttc 65940 agtggggtag aattatacac tagttttctt ttttataaat tttgatattc agaattttct 66000 gtgataaaaa gtttgttttg agggcaatat tcttccactg aatttatagt taaagaaata 66060 tatttactga tgacttctta ccacacacaa gcccagagca tccacatgcc agttcatctt 66120 gggaacagac ttgctcttgg tacatttggc ccaaaatctt atggctctaa gttagaagaa 66180 acctacagtt acccaccctc cacacaggat aagagttgta aaatacaatc aaatactacc 66240 attctgataa tcccactccc agaatgaaat tctttgcata agcaacacag aaatgaatgt 66300 ttctatccaa ttccttcttt ctctcccttc cctgttgagg atataagatc tctccacttc 66360 tgacccatgt tttgctaatc attataaaag caagtaataa aatcaatgag gtaaagaaaa 66420 taaaatgttt aaataataca agtttaaatg actcaagttt aaaataagct taaagtgaaa 66480 atagacctaa gaatatattt taaataataa tttataataa ggacattgac ataagtgtag 66540 aaagtttctt ttcctgatct gaaaggcttt atatgaattt tcatagattt gtatttcatg 66600 gtatatccct tgaacttact ctcccaaaaa agaaatcact aatccatgac actggagctc 66660 tgaagttcaa ttaaaatagc acctcaaatt attttcttta acaaacaatg attttattac 66720 cagaaaaaaa atcataaaat actaagtatg agtgttgaaa ataaattgtc acaactggtg 66780 aaagcagtga taaaaatatt ttttgtgttt gtaattttaa gagaaagaca atcccgttta 66840 tcatatcatt ttatttttat tttaaacaat ggataataat aaggttgtaa acatttatga 66900 aatactgatc ttcctcagaa aaggtttatc ctaagtactg ttttttgata acactgctta 66960 tgataagcta aagtttgatg ccagctacaa aatgacaggc tatttcatag gttttaaaaa 67020 tgttgagttt tacacttttt ttcttttgtt tttgcttttg taggtttttg tttttgtttc 67080 ttgatgtgct ttttgtttca ttttgtgagt cataagttaa cactattttt atttgctctt 67140 ctttcgttgt catttgctga cacatttatt tcaagttggc aagacataag ttttctgtgt 67200 tttgtttttt tagacagtct cactctgttg ccaaggaggc tggagtgcag cggcgtgatc 67260 tcggctcact gcaacctcca cctcctgggt tcgagcgatt ctcatgcctc agcctcccaa 67320 gtagttagga ctgcaggtgc atgccaccat gcccagctaa tttttgtatt tttagtagag 67380 acagggtttc accatattgg ccaggctggt ctcgaactct tggcctcaag ttatcagcct 67440 gcctcggcct cccaaagtgc tgagattaca ggcatgaact actatgcccg gcctctattc 67500 ctttgatatt ggaggacaga ttatgtctat catttgacag ttacaaatta tcttgtttaa 67560 ggaaatacag ccatgttttg ctctaggaag aattctgaca tggtataaaa attaaacaac 67620 taccgttcta caaaatatgt ttaaagatca ctgtcatgat tgaggtgaac ttatcatttg 67680 aggtgaaact ttgcaacaat tgggtacttg ggaaaagatg ggtgcaaagc ttcaaggaga 67740 gcgattaggt tagccatgtg taggattttt cctttttacg gaaaaagtgg aaactagacc 67800 tttttgtttt tcttctctga gttatatatg tctatttcct ccgctgtata agattctcaa 67860 acacagggat gatatcatat tcacattggt acacattaaa tgaatgttta atgcattgaa 67920 tttgttgaag tgggagaaag aaagagggag caaaatgcta gagatgtaaa agctagttat 67980 atttacttga actgtattcc taattggctt ccactattga ttctgtgtgt tcaaatgggg 68040 ctttcagtat cttaagttta aaatagattg atgtgtttcc aaatatatct gagctggctg 68100 atctggtggt cacttgactt taatacttgt ggccaatgga aaaagggaga aaaaggaaga 68160 gattcaataa atactccaac aggagaaaat gtacaatact gaattaattg gagcaaaaag 68220 aaatgtttaa cttacagagt tactgtcatg gggattgaat gtgataatat atgttgtctt 68280 ttttagagat catttggata caagaacctg aaaactgttt actaatacaa ataaataggg 68340 atacatttta gagggtacag gaaaattcct taatgagtaa tcaaaaataa aaaagtatag 68400 cttacctcat aaaaaattaa aaagtctaca ttactctctt tatctctttc tctctccctg 68460 ggacctcatg gtctgtcctc aactcatttc tctaaatgtc tgtgccattc tttatgatat 68520 ttttggccta ggataacaga aaatctaact acaagagggt tatacaacat gagattcatc 68580 atcttatata acaaaatgtt tggaggtaga acagattcag cagtggtaat tcaacagatc 68640 aactatggca tgatggatct aggttcttct tatctttata cttttctgcc ttagcctgta 68700 ggcttacctg ttaagctggt gacttcaatc gccctcagat aaatacctca ctctcatgcg 68760 tctgttgcct tgagaaagag aaagggattg tgttctttca cgcacatttc tttttaagag 68820 caaatactat ccattaggtg tactctggca ataattttat ttgtgaacta catagtatta 68880 taacaataat ttaaagctat ttataaagct ttcaaatgga gatagtctaa agatataaaa 68940 atatgagatc agataaaagg ctaggaaaaa aatccaactt tcactctgag actattaata 69000 gatcaaaaag ttataggcag tcacatgtaa attgtttaaa tttgtagaaa ttttattcat 69060 ttggaatact tttcatatta aagtttatta taatagctgt tatagtaatt ctaaattaaa 69120 taaataacat accaaaaaat ctagtagagg caataaaaat gtataaaaat aagaatgatg 69180 caaatccaaa tgtaaacttc agagaaaggg gcaaccaggt gtaccttaac atggagggag 69240 gaaactgagg aaagtttcat ggctaaagtg atatttgaca tctagaagtt gggatagagg 69300 aaacctacac aaaggaggga aacagagtaa atatagactc acaaaagcca agttgcaaat 69360 acatgaataa tattatggaa tcatgagaaa tttcatttca taagagcaat gaaaataaca 69420 ataacatgta gagtggattt tgatcatgaa gttccctgag agtcaagcta agaagtttta 69480 gttttgcatt tagaagccgg aaaccataac atatttcaag gagccagtaa tgtgcttcag 69540 aaaatggaaa tggtctgcag aatgttgggg aaattggaga tctgtagaca ctacaatagt 69600 ctaagcaaga attcatgatt atctcaacca gaggtgaatg agaatgaaaa tgagagctca 69660 aatccatgag attgtaccaa gttgtagagg cataaaacat aaccatcacc tggataggaa 69720 gaaaaggcaa gtctaagatt tttggaccag accatagaaa ctagaagaaa ggtaatgcct 69780 ttaccaaaag tatgacagtg aggagaaatt ttttaggaag atgtgatgaa ttgttcagat 69840 ctgggtccag tgcaattgag ataactagtg ggacgttagt tgcaaatatt tgggaaattc 69900 aagtctggag cctggaagaa aattcaagag tatatttaga aatatagatg tcttcaacat 69960 attgataata cacaagaaca taagaggaag agaagaggtg aaaataaata gattcatgag 70020 atgaaaaaca aaacattact ttctcataat gtgtattatt ctatccgaat catataatag 70080 tcacagtttc aggatgaatt tctgccatct taattgattt ctcaaagcca ttatctcaaa 70140 gacgttagta tcattgtttt acagtttatg aaacggatgc tcaaagaggt tagacgtttg 70200 acccaaagca tacaatctga aagcagagat attggaacac ttgtgcttgg ctttagactg 70260 taaatctcat ctttaatagt ttatagttaa ctgaaataag tataaatata aaagctttgt 70320 atttgaaata ttaaagaaaa tatgtatata tatgaatgta tatatatatg taaatatgta 70380 tatatattat atccaagagt aatgttcagg aactctatat tttaattaaa taatttaaac 70440 atctctactg ttctctaaat tccttcaaat tttgaatcat caaaataagt tcattcagat 70500 tttataaagt aaagggatga gtggattgat gtgagaatta tcaggcaaat atgtaatcaa 70560 attcccatgt actcagtctt acgatgtagc atctgtgaat agctgcagtt tccaaattaa 70620 accagccaat tgtttcatta atgttactaa aaatttaaag tttaaaagct cctagttgga 70680 caaatggtga attaatttaa attttaaatc aagagcatcg ctttgctttt gtattgtacc 70740 attctaaaaa tcccaaaggg ttaaaaacat gattatacac ctatgttcaa gattaatttg 70800 tttataagga cagctgtgcc ttctgatttg cttatttgca tcctaagttt gtgtgtttac 70860 aaaatttgac tgttcaacct gcagatgccg tttttaatgt tttgcttcaa aacttttaac 70920 cccttgagtt tctattttat tccatgtcat ttatatatat acatatgcat atatgtgcac 70980 atatgcatgt attttataac ctaacatata tatgtatgca taatatatat aaactatata 71040 tagaatatgt atatacataa gctatagtat atacaattca gttggtaggt ggtctgttcc 71100 ttaaaataaa actgtatttt tctctacctt ttccttggag atggcctttc cttagtatag 71160 tctatagaag gctgttataa gccggttgca atagcagtat gtgggcaaga ggactgtaaa 71220 ttcagtgaat attattagtt tatgaatatt cattaaattt gtttgtatgc agcaactcaa 71280 ctttgtaaat ggttgcagcc aaaaaaagct ctaattagag gaattaatta gtatttggaa 71340 aggtatacag ggataagtgg gcattttgaa gaggtatttt ttcctcctgt tgagaaaaat 71400 accttctagg gagcttgcaa tacaatttgt gtgcatatca ggtagaaata aactggagcg 71460 tttccagttt taaggccgca agagagcgga ggtcctgttg ttcaagctag cacaagatac 71520 tttgtagatc acagaatacc ttggtctttt cttgttggaa ttcaccatgt tttaaaagat 71580 gttgttactc accaaccttc aaatgccaca tttaacccta ctataaagtt aaaccaagtt 71640 aaacaagaat aatctgacaa cggaaattat tttccatgtc agagtggtgc ttctttgcct 71700 ctgttacctc cataatatcc ctgccaccag caaccaaaaa gaagcagctg ttctgaatat 71760 gtacaaacaa aagaagctgt tactatagca accatagaac cctgtggaaa agctctccct 71820 ttaacactag ccaacctctc ctcttcaccc ctccttcctt tcctttcctg cgccagcaca 71880 gactgccctt ggacagaaat gatactttgg cgattcgaca tggggaacca gagtaaacac 71940 tacagcctgc attcacactt tccaagagct ggaagacttg ctcctggcta aatcctatga 72000 aaaggctgca gaacctgaca acacttatga agctctttgt tccttgtttc ccaaaccttc 72060 cttcatcctc ctttaaaaaa atcctactgg cctctctcac tcatgacttg atgaagtaat 72120 gatatctctt ttacctctcc gttgtcagtt tttctctatc ctatatccat gttcatgatc 72180 caaatgtggc attgcttaat taagtctgtg gattttgctg attccagagt tggtgttgaa 72240 ttggatggaa gatagggcac ttttgacttc agaggtaaat ggatgatgct agatgatcga 72300 tgctgttggg ttttttccct ccatgtggta aaacataaag gcacaattta taaaaaaaaa 72360 cccagcttca gaaaatctgt ccaaaacgat tacaatttga ggcctttctc caaagttgtg 72420 ttttgattaa tcaataacat ctttcactta cttttttatg tcctttgata gtcagccttc 72480 aatttactaa ttgcttgtac tgccaaatta gtctttaagt caatcattta ggaacttaaa 72540 tttgttttaa gtcagtaatt taaaacgtgg gacatatttt gttgtagata ctatctacta 72600 actactctgc taacccaaaa catggctgac tatcttgcta acacaaatca atttatttca 72660 tatttctctt aaatattttc tttgcttgtg atgaaattgt ttaatttcaa aagcatcaca 72720 ggcagattaa aatgttgtag gatactattt gagtttttca atttacagca taggacttta 72780 taaatagcct tgtgattcaa caataacttg aatgatgctt tctaactggg gctaaccctg 72840 gtaaaatttg ttcatattaa tttaaaatcc tgaattaaaa actaagacat gggtaattgt 72900 cctattggtt attaaaagtg ttttaatact ttcattaaaa agaccatgaa gtattcaccc 72960 atgaatatac aggtcagtgg gatatgataa aactgagaaa acggcccact tatttatgca 73020 gttatagtat ataataaaaa cagccttctg tatctgtggg gaaaaggtga gttaattatt 73080 aatgatgtgg gtaccatttt agcagaatct gggggaaaaa acggatgtat actttaaaat 73140 ttacatcata attaattcca aaggggggag ttaaatataa acaatgaaac tccaatagca 73200 gtaaaactat gggagaaaga tgatgagagc actgaaaaac ctctttccac ctctcaagtt 73260 caggaaaaat atgtgtgatt atatttggtg ttgataagga tgtgaggacc aagctttcat 73320 ttattgtttg tggaaatgta aattggtaaa atttctatga agggaaattc cgatataact 73380 ttaaaatttt caaatgtata tactgcttat ttttttattt ttttaaatgt gccatactct 73440 ttaactgagt aaattcactt ctagaaaggt gtcctacatg tacaattaaa catactagga 73500 atgacaagag tatgtacatg gttattcatt gcagcaaaat attagaaata ccatttatgc 73560 ccatgaatat gatatgggtt aaataaatta ttttacattc atattatggg aaaatatgct 73620 gccattatga gtgagagatt gagacagaga gaaaggatgc tcttcataaa ctctttataa 73680 acttatatgg aataatctca aagataaatt gttaaatttt tttaaagcca gaaaagaaca 73740 atgtacagag cattctactc tttgtgtaga aataaaaatg atgtgtgttt gtgtgtgtgt 73800 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtaatgtg cttagaacat ctttggaagg 73860 acacacagag cacagattca ctagaagcat caaatcttct ctggagaagt agctcagttt 73920 ctgcattaca gctgggaaag agacttcatt ttataacttt tgtgtatgtt gaatttttaa 73980 gatattgccc atatgaaaat ccctggacgt aaaatggtct gaaaatgatt gctttctaat 74040 ctctgctgct caaatgtttg gcagaaaact ggaagacaat agcatagatg taaagaaaaa 74100 cgacgactaa aataaatagg aatcaaacaa acagttctcc actaatcaag ctttttttgt 74160 tttgttttgt tgttgaggaa ctccttgatc ttctgatcac ttctggaatt tagacttgtc 74220 agaaattatt gtgacaacaa aggggtgcta gacagacttg aaatgttaac aaaagggact 74280 ctattgccat gttttagacc ttcttttcac tgataactag gtctttcaca aattcacaag 74340 ccctttcttg tagttggatt tttgttttgt ttgcttttgc ttaacctgtt gtttcacgtc 74400 aaggcgcatg tgccaaatgt gagcaacgct gactagtgct gaaattgaac tttcctgatc 74460 aataaggggc acgggtaatt tcaagccttc cttcctttga cacacacaca cacaaaacac 74520 acacacacat ttaaaaagaa aatgaagtat acaggaaagc aaaaacatta aatgcttttt 74580 agtagttttt agtagttaaa atggaggaag ggagaaaata agtatgaata gcagagcatt 74640 tgttataaaa gaaaaaaaaa agttctgcaa tcccagctac tgaggaagct gaggcaggag 74700 gatggcttta ggctaggggt ttgagaccag cctgggcaac atagtgagac cccatgtcta 74760 aaaataaatt atgtaaaaat taactggctt ggtggggcat ggtccccgac acttgggagg 74820 ctgaggccgg aggatcattt gagcccaaga gcacaaggct gctgtgagct atgattgtac 74880 cactgcactg cagcagcccg ggtaaaagag tgagacccta tttcaaaaag aaaaaagaaa 74940 agaaaaatat tcagaatttt gtcatcaagg tgaagtaaaa ttcattcatt tattgtattt 75000 tgatcatatt cattcttcac tatgtattga gccagctcca tgaaagacag taatatgacc 75060 acttaaattt gtcgttatca ccccctctat taaattcaat aaacattttt tgttatcttt 75120 tacaaacact gcttgttagg agaacagtgt ggtgtcaaca aagtaagaca tatgcacctc 75180 tagtccctat gaagaaaacc ttccagcaca cagcaaagga cctacctata ttagaagccc 75240 cacagaattg aaagaattga aacccatcga gaagagttgt tgcagagagc gagattcaaa 75300 gtgtgaacac tcatccttgt caatcagggt tctcattctt aaacacaatg tcagaagtaa 75360 gctgatggtt atatttaata tttaggcaag aagatatatg tgtatgcatt tttggacttg 75420 tacacatacc aggattcaat aaagtatcat ctattagtgg agttttgaaa ttaacatctt 75480 catttcattt tcctttttct gcaccctgca atcaggcttt ctttttcttc caccttgttc 75540 cctgaagagt aggtttatgt tgaatgttgg tgttagtagc agcttgatct tctgttttgt 75600 gccttcttgt attctttttc ctccttcctt acccttctcc tggttatatc caatacaata 75660 aagtcagtgt agatattcat gtcagcattg tgacatttta atatttttta aatttggttt 75720 tatagctctg atgtttatat ggctatatat gtctaacaat ttaaaaatat aacagcttta 75780 aaaaattatg ttggctaacc aaaatatgtt ggctgagctc tctttgccta tttaaagtaa 75840 atttattttg gctagagtaa atgtatgtat gatgcttcat aacatactaa aatatcatga 75900 atttgggaaa ataaatttaa agttgaaact gcatctgctt aaagatattt atgtttacat 75960 tggacatttt tacaaatgtc tttagctttt taaaaataac tcatgaattg attttttaag 76020 gcatctgtat ctaagcttac attgtttatt ccctgtcagt ttcgatctgg cttttgtact 76080 tgcagtaatc tgtaaagaga gtgattattt atgcttggac ataattctac tggaaaaata 76140 agtctattct atacatttta aagaggattt atgtatcatt ttgcatttct agtagtttct 76200 aataatgacc tagaacaact tgctagatta cactagattt gaccatcttt aacaatattt 76260 agataattgg gaaattatac tgtctataaa atattatgaa ggaggctaca tggagagaag 76320 gcatatctcc ttggaaatga tttccttctt aatacatata taaaatatga ccacattgtg 76380 ctttgaattt ttatgatcat gctagccata aaatcaaagc gtgatggctt cttgtagctg 76440 ctgctatttc tcttttataa aatgaaactt tcagagacat catactgact gttcattttc 76500 tacttcctga tttgcagtac tctgacatga gttttccatg aaaccttaag gaatcgtaca 76560 gttgcagtaa tatactattg ggaaatattt acctattttt acgtgaaata gcaagagaaa 76620 agccaaatat ttggaaagaa agaaatacta aagaggaact ttataaacat tgcctactga 76680 tgtaaaatct ttccttagga cagaggaaaa aaaaccctca caaacacaca tttcacacac 76740 atagactcct gtagcatctt tattaaattc ctcacatcaa tttgttatgg tatttgtcac 76800 attgtttaca caaaggcaaa atagctaaat tttttaatct ccggagacta ctatagtagt 76860 tgacacatag taggcagcaa atgaaagaac caataagcat aagtagtaaa aaaaaacaaa 76920 agcaaaacac acacacacac acacacacac acacacacac acacacactg caaatgcctt 76980 ccttccagat taattttcta ctaggtattc cacccaacta agacagcatt actagccctc 77040 taacttcccc tggtcattca tttctcttaa cacaattcct ataccccatt tctctccctg 77100 caatttggtt gaatgtttac tctctatgga tgcatcaagc tctggccatc gtattttcta 77160 acaattttgg aactttacgg atccttttaa gtatcagcat ggtgacagaa actagaaaga 77220 agcacactgt gtaacttgca gtgagtaatt ggcagtttca gatagtgaaa gtcaactgtg 77280 tgtgggtgct atttgcaatt aacaaactat atctacttgg tatatcgtta agtggaaagc 77340 aaatggcata gtaataactg ataaaaatgg atatagatac agggcttttg ggttcaaaac 77400 tcatcaattg aatgatttta aaaatgtttc aataatattt gtagtgttta ctgagtactc 77460 agaatggtgc ttaatgaatc atggctcctg tcttaaagga gcatacattc atttatgaaa 77520 ctaaatttgt acagttgaga caaagttata gaaatttcaa gaaattagtc agttggatgg 77580 aatcttaggg catgattcct gaaattctta tagaaaagtg gacaaaaatt agaagagaga 77640 atcatagtag cagtgatgga tctcattatc tctgttctat ccattgtatt ataaaatact 77700 ttcaagatga catgatgaat gtgttatttt actggctgaa ggttcttcct cttcaatttt 77760 aaagaactgc ttaaataatt gttccttaat ttcatagaat atattgattg cttattctag 77820 ataaaacaca gattaagact catacctccc atgtttacct atacctttac agtttcctaa 77880 gcatatttac attatttata taactttatg tctcatgaca attttataag gtgggcagac 77940 aggagttatt ataactatca tataaaaatg aatatgaggc atatactgac agtatgacta 78000 aaatccaatt tttatggctc ttccaaacat tcttcagatt ctcccattaa ggagctcaga 78060 ctttcaaaac acaaacacct gagacatata gactgagttc taaatgagtg aagtgtacaa 78120 tgctgctagt gttgagagga acacccccag tcaccagcta aagtttgtgc catagggtgg 78180 tctttatcaa tttcacatct ggtaattgta tcagaatgga tctaaaatcc atagtctttc 78240 ttcccactgc tcccaaaagc ataattcttc tctccacatc tccttcattc accctccctg 78300 tcccagtgtt agtctctctt tccttccaac aagatctttc attagctcaa gttatttgct 78360 gacaagatgt tataacaaaa gcctatatgt atatatatat acacacacac acatatgtat 78420 atatacatat atatgttatt tcttgatccc tttgaaataa attgtacatt gtgtagaaaa 78480 aaaacaaaca aacaaaaaag ccatgaaaaa ggaaaggaga tctctagtca gggaaaataa 78540 aatgagtagt tggagaaaag cagtggagag aaagataaga tctaaagaaa agagagggaa 78600 gcagaaagaa agggagcctt tgtattcttg agaggcaaag agagcaacgc tgaatgttgg 78660 cttctcaatt cctctgccca ttcttgaggg actcaccttt actatctttc ccttctttgg 78720 agattcagca actcaactca aattacatta agggagaaaa aagttgagac ttattaggag 78780 aataggaaat atcagaatta aaggaatgtt taacagtcac actctaggaa ggggagaggt 78840 tctggcacag ctgagaagca gctggatctg tagactcaaa taccaccatc cactcttatc 78900 gaatccctca tctgtgcttc tctttgtatg atgcacctca cactcaggca gatttctttc 78960 cactgttaga aagtgatagg taaacattgc cagattaaaa ttagactgcc tgacttagat 79020 aagagcacta tgacttagtt gcactaagac ttggacatcg actctaacct acagtttcct 79080 tacctgtaat atgtggtgta taatgataga gttgctgtta aatgttcaaa gtgcttagta 79140 gaatgtctga acttaataaa tgtgaatgtt gttgctgtaa tcgaatcaga tattttgact 79200 ttggggaaca ttttttctta gtgctgtcac cagacagaaa ccctctttct ttagttacag 79260 tttgaaaaca acttgaacaa cttgagaaag cctctgataa tctcatcata tgttcgggtt 79320 gtaaggacac agggacgttg aaactccaag cttgaagtca gaagaagaaa gatatttcca 79380 gaggaaaagg tggaaatgtt gctaagccaa ccaagcaata gatactcacc atagatatca 79440 gaaaaatcta ttcaatgcct acagtagaac tccctcactt aagcttgctt gagtagcttt 79500 ctaatcaatt ccttgatata gacagggata taaatgtagg gggaaatgta gatgaagcaa 79560 aagtgttaaa attcaatatg tgtcatatga ccagaagaga attgtgttac tagtttttac 79620 agaattataa aaacaagctt atttttgctg taatgtatcc acctgactct taggtagaac 79680 atttttaaaa ggcattcata aacttagaaa tcacagccaa gcaactagaa tgatagagca 79740 attgtaatta gttgctattc tacacgtaaa taatgtattg ttcataagtg aaagaataat 79800 accttgtgcg gatctttcta aggaagtttt gttagaatgc attatctaga gaaatcttac 79860 gtgtgctgtt caaaagacca tatttaagta ttcaataaag catatatttt agagggaaaa 79920 tccttttaga gcagatgctg caatgaaata aaatattgaa gccaagctta tttgtatgca 79980 taccaacact aaacatttct ggtgtaatta ggttaaagac aagtgattca ctacttttga 80040 tcgcattaag aatactagta tatggctcag aagatattat ttagaggagt aatgagaagg 80100 ggaccattaa tgttacttca ctcaaaataa aaatttatag tattttggac ttttaatggt 80160 aactaagtga ttattctctt aaaacctaca aggcatagac attaagggga cgcagaatta 80220 ttgcatgggt cccctaaatt tacaggagaa ataagcatgt ctgaagattg aataaataac 80280 atgtcttgca cacatggtga tttttttcaa atgcaaggag gagtttattg agatttataa 80340 aaatgtaaat taatttaaaa tattttctga atgatggttt gtgacaacta atttcctgtt 80400 taaccaatgt atgtcagagc aaagtattgt tttttgtttt tctacttgag acttttttta 80460 gaaaattatg caaggtggtt actaaactag aaaatgtttg aatcccctgc gttagatttc 80520 cactgaacat gtcacgtttc aaactatgtc aaagtgtttt tgaagataaa taagtattct 80580 agctagctat cataagctac acaaattcat agcattaaga aattatgtgc cacatgaccg 80640 tacacttggt taacatagtg aaaatactaa agcttttcca cttaagtgac gttattatct 80700 ttcattttca gtacacactc tatgcaaagt tattacatat tcttcaggac tttgtatctt 80760 ttgaatgttt taataagtgg gactctgaag gcaatttttg gcaatttttg tgaagttgag 80820 aacaattagt ggaagcaaat acacattctc atctagaaag taattattta tcaatttttg 80880 acatttacat tgtttcaaaa ttctctcatt ttaaaaattc caaaagcttt tgttctctgg 80940 atattttttc tttttctact ctttcctctc ttcctctgtt ctttcttttt tccttccttc 81000 cttcctgcct gcctgttgtc atgttcttcc ttctttccct ccctcccttt ctccttcatt 81060 tggtcctcaa tctaatcaca cctagcttgc aacttatttc caatcaacat cagtgataga 81120 tctaagagca attattgtga catgccctta ctattcttga gttgtagaga ccccaggact 81180 tacattgttc aagaaattgg gctgagaaac cttgacaggg ttaatccatt gtgatcacca 81240 ctgaaaatgt accgtgattt gtcctaggga tctacttgaa agatgacctt tctgctgaca 81300 agtttactcc ctcagtgctg ggctgagcta ttctccccag actccaatga taccatgcag 81360 ctattagtcc ctaggctagg tacaacttcc caggacctgt gtgaggcaag gttgcaggtc 81420 tctaccatta acagaggaca atccaattta ctcctctgac ttgggcctct tacctttcaa 81480 tccagaagtc ccaaggtctc tagtctattc tttacgtaga gtacagttaa atattccctt 81540 cacagatcta catttttata aacaaaaaat tgttactcct ggaggtaaaa gaaacccagg 81600 cccaatcttt agctacccat ctgggaaaga gtggcaagta cctctccttc tttcatgagg 81660 agtcaaaaat ttctcaggtc attctttaac aaggaatttt cattagatca accaattaca 81720 ctacatttga atattattta tgtcatcctt tgtttcctca aataataact gatttttcct 81780 tcatatttcc ttggcctcaa aatgtgaacc cttaaatgtt ctcctgtgca tagcaaatca 81840 tgagacttca aaccttagct aaaaggcagt aaagttgtta ttgcttattt gcttttaatt 81900 tttattgaaa cttgtgtaaa ttgactcaca ctttaagtag acaatgcaaa cctataagag 81960 aattcaatta taaagccttt ggtataggaa ataatttata cagaatgtaa tgctttatca 82020 gatttgctcg attatatgct ggtttctaaa aacaatacaa ctatgggtat atacaaatat 82080 gtgtatatat acatgtatat gtagatacgt aaatgtagat acttatacac atatatatgt 82140 atatgtagcc acatatatac atatatatac gtttatatat acccatagtt atttatatac 82200 atataaacaa tatgtgtgtg tatatatatg tgtgtgtaca tataaacaat atatgtgtgt 82260 atgtatacat acaaacttta agttactttt taaagcgaga atttcttcaa catttttgga 82320 ttgctgttta tacaaaaaat aaatggtgtc tcagtttgac taaagaatat aacctccaat 82380 aacgatatag cctggctgct tatactgggt cctgcccaat gtttatatct gcccaggatc 82440 tcagggaact ctcatcccct ccagagaacc ttccctgact ttcctctcag ttcaaggtct 82500 aggtctcatc tttttcctag aacacactaa ttaaacacat ccactttttc ttcaacatat 82560 atttactcag ctcttgctat gttttagcga caacagatcc catggaaaca acagagaaga 82620 aataagttgt ttttactttt ctcccggtaa ccagtgttag accatatctg catataaaat 82680 ctcctttaag agttgatata aacctactat tactcatagt actcactcca gctttggttc 82740 tgcccaagta cagtgagctt attgagaata aggaatatat ctcagttgtg catggtagtg 82800 actcatatga attggatggc tgtgcatatg aaaatatggc actcaatggc agtttttatt 82860 gaaaaaacta gataacttga ccataattgt cctaagaaac aagacattca tctgcaattt 82920 acttgcactc aataagcatg ccctagttat tgtcttgtga gaaatccaag gtctgatatg 82980 atgtactccc aggatagagg ggtaaatttt tttttcatgt cattctctat agcatgatta 83040 tgaacctgaa gaaataagta tctgtgcatg gcagttcctt tacctagaaa tcttggtaac 83100 tgagatatct ttgtggtcaa acgtttctaa agatatatac atttttttgt ggggattaca 83160 gggagaaatg gctaacctta caaacattct tgggagattt tgttttgttt tgtatttctc 83220 accagatttg aattttagca aaaaaagcta tattatttca tcaggaatct gattaagact 83280 gcaattttga aaagggaaaa attcattaaa tagactaatg gaggaatctg aagggtagtc 83340 agtaaaagca gctgcttttt caatacatgt tgggagattt gtctgggagc ctttcttcca 83400 aatgatacta tttcaatcat gcctaacatt taaatctcta aacactgata ttcccatttt 83460 aattttagct ggcaccagaa ggaaatggta aaacagcaga tgattacctc agtactttat 83520 tccacatttt ttaacagctt tacagattca aataaaaaat aataatctaa aaatgaaaaa 83580 tgcacaacta aaattaaaca tagaaaaaat atttttaaac caagagattc tttttccttg 83640 taacctccca aatggtggaa agtaaatttc acagtggaat gtacacagga cttaatttta 83700 ccacggttat attatatttt gatgactaac ttaggcttta aaaaattgat attgattcag 83760 gccctattaa cttaaatttt gtgattattt agctaaagga ttcattgatg tttgtttttg 83820 aatttgtgtc atctaaaagc gaatctcact ttagaaacac cctgtgtata agctaaattg 83880 tcctttaaag cgaatcttct aaatctttta atttagttta attagcaatt tcagggccag 83940 gcacagtggc tcacacctat aatcctagca ctttgggagg ccaacgcaag aggacgactt 84000 gagcccagga gctttagact agcttgggca acatagacct catctttcta aaaaataaac 84060 aaaaattaac caggcatggt ggcaggtccc tgtagtccca gctattcagg aagctgaggt 84120 ggaaggatcc cctgagcctg agagttcaag gctgcagtga gctgaatgtg ccactgcact 84180 gcaacctggg tgacagaatg agattctgtc tcaaaagtag aaataaaaac aagtttaaat 84240 ggaagcaaaa gagttgaaat tttcctcaga tgtaatataa aataattggg agaagtgtca 84300 catcaacagc attaatgaag agtctaatat atggcagaat ttgtcctagg tcctgggtat 84360 agcagccatt ccattagtag agtttacatt caaacctatg accttaacta gaattggaac 84420 attggtacat cattcaacct cttttggttg tttctataag taaaattgac ctctggttta 84480 gctcatacta ttaaaatatt gatttacttc gaatgaaaga tttatacaat tatatcagtc 84540 tcttgatgtt tactgaataa taaaactagt atgtcttttt atgtttattt tataactcac 84600 ttatgatgat taagttatga aaactcaaaa acagaatttt agtcaacata attagagtag 84660 aacccttgaa atgtgaagca ttaaattaaa aatatcactt gtttctctct atttctctta 84720 acttagtgtt ttgataatac taagatctta atatacctaa ttcaaccaca ataaagcaga 84780 tataaataag actatcactc tggttgagta tacaccactt ctagatttct tcctcatttt 84840 aatttagatg taccaagtat atgccaatga ttttttttcc aaaatatatg ttgactacag 84900 ctcatagtta gtatttcatg tcataacata cataatatgg taaatgtttt cataattcaa 84960 taattaaata atagtatctg tctaaatatg tctgtattgg attgaaattg ttatcatact 85020 ttaaagtagg tatactgtac ttccttcaac ttgttttgct aagagctatt caatgtgaac 85080 atctttaaaa taaagcccac gatcacacag tgtcacacaa ggattctaac taaacactcc 85140 tgagtgaaac atgtgggtaa acaaactaca ttaaataaag aaaattggta aacttttaga 85200 ttttgttttg ttttgttttg tttttgagat ggagtcttgc tctgttgccc agtctggagt 85260 gcaatgacat gatctcagct caccacaacc tctgccacct gggttcaagt gattttcctg 85320 cctcagcctc ccaagtagct aggattacag gtgcccacca ccaaacctgg ctaatttttt 85380 ttgtattttt agtagagatg gagtttctcc atattggtca ggctggtcta gatctccttg 85440 acctcaggta atccacctgc cttggcctcc caaagtgcta ggattatagg catgagccac 85500 tgtgcctggc cctttttttt tatgtaataa gtacatgttt taacatcaac catatagaaa 85560 agatcctctg ttctaaagaa ataaaataaa ttcttttgga aaaagtgtta atttttgttg 85620 ctgttgttct agagaaaaaa ctgtcagaga atcttaaata ggaaaaatgc tataaagtag 85680 gaagctttgt atttctggga agagtgttat tgtggcactt attagattca cgacagaata 85740 gttgattcca gcccaatgta gacttagtga cagtaaattc gtatatttat tttagaccaa 85800 aattaattcc ttgcaaagtg actcttgttc taagcactcc acaagagctg ctttctcaac 85860 agtctccaaa agtttgctaa gtcctaaata cagtggcttc ttcataattc attttttctt 85920 tgcattttat tgctttggat ttaaggacat tacttcctgc tggttttact tttctccatc 85980 tccttttcta gctgattttt aaaacccatc tcttaaatct cgtactctct taaaagtcaa 86040 tgtaagttcc ccaagtttct tttcctggac ttgctcctat ggtcttgttt caacaattgc 86100 atttttttcc tgtaatttat aaatgtacag atccaaccct ggttttttac ctgctacctg 86160 gatgtctcca cattgaaatc ctactaatac ctcagtctct cttcctgttg aaaactgcac 86220 taattatttt aactattttc tttcaaatct tttgctggct cattcattaa tttaattttt 86280 gctagaaatc ttaattttct ttttacaatt tttataccct ccctatccct tgttataaaa 86340 gtaattgcca aagttgtcga ttcactctct gtgatgtctt tctttttcgt tctctttcca 86400 tttttccttt tctcatttct actactcttg tacagtttca gactgctgcc tcttgatcta 86460 ttgtagtaat ctcctttctc ccctctctgt tttcagtttc ttccttctca aattcaccct 86520 ttgttattat gaaagtcatt gtgttagttt ggcattatgc actctgggaa ataaaagggc 86580 tatttctaag gatattatag tggaagtaac aaatatcatc atcatttgat aaataaacta 86640 tattattctc ttgtatttgg atagtgtttt atcttgttca aaatgctttt atattcataa 86700 ttcatataca ttattgtaaa tattaaaata ttgttattta ttataatatt taatcaagct 86760 taaaatggga aaatataaat gatccactta taaaccatgt gggctactaa tctgcaaata 86820 ggtcctttac aacttgacta catatcaatt atgagttttt aagagaaaga gaaagcaaaa 86880 agagaaatta aacaggaaag ggaaatgatt cttgaaccca agtcattcat ctaggaaatc 86940 ttacagcaaa gaagggtgag cagcttgttc caacctaatc taaaaactat aaaatgaaat 87000 aatcccatct gtggcaactc ctctaggatc ccaaccgaga gattacagaa ttaaagtttt 87060 tagttccaac agaactgact ccaactaaca taaacaacaa attattgaaa aaaaatataa 87120 ggcattctcc aacctgagtt gttggattca ctttagcacc accattagga tagaatagaa 87180 cacccagagt tttcagcctc tttgccatct gctcagaatt ttttctcatg attcagattc 87240 cagggagcag gcatctgaat ggcctggttt aagtcctaat tcgtaatcta tctcataagc 87300 ttctgtgaaa ttataaggta tattttaaat atataaaata attatgacaa aattgtgtat 87360 gtgtccattt ctgtaggaga ttgaaattat atgtgagtat cttccacatc aaactaggcc 87420 aaattaaaca agcaaaaaaa tagtgtgagg aatatttggg atgacacaag ataataaata 87480 tcaaaactac cccagcaaat gttatccatt ctcacgatga gcaaacaagt aagaaagaaa 87540 caaagacagg gccaaattat aagcaatttt aaaatttagg gtttcctctt gatttttaaa 87600 ttatttttga tgaagttcaa atattttctt taggaatcaa actaggattg attattatta 87660 gtcaggggtt tcttttcttt tcttttcttt tcttttcttt tcttttcttt tcttttcttt 87720 tcttttcttt tcttttcttt tcttttcttt tcttttcttt tcttttcttt tcttttcttt 87780 tcttttcttt tcttttcttt tcttttcttt tcttttcttt tcttttcttt tcttttcttt 87840 tcttttcttt tcttttcttt tcttttcttt tcttttcttt tcttttcttt tcttttcttt 87900 tcttttcttt tcttttttct gagatgtagt cttgctcttt tgcccaggct ggagtgcaat 87960 ggcgcaatct cggctcactg caacctctgc ctcctgggtt caagtgattc tccttgtctc 88020 agcctcctga atagctggga ttacaaggca cacaccatca cacccggcta atttttgtca 88080 ttttagtaga gatggggttt caccatgttg tccaggctgg tcttgaactc ctgacctcaa 88140 gtgatctgcc tgccttggcc tcccaaagtg ctgggattac agacgtgagc cactgcacct 88200 ggcaggggtt cttaatcttc tgttgtgccg tgtgtgtgcc tctttgacca ttctggtgaa 88260 ggctttcaag ccaaactgag agtaaatttt taaatccgaa aaatataatt cataggaaat 88320 gaattgactt aattaaataa ttagttaaat gattttcaaa atatgatatg aagtttatga 88380 cacataaata agtttgcttc ttcaataaca cattaaataa gaaaatgtaa ggtaatgatt 88440 tcaaagaaat gacatgtatc aataacagtt tgggatatct acaacattgt agttgatata 88500 aagctatgtt tattttctat tggcaacaaa gtggtagaaa tttttaatgt ccttgagcta 88560 aaaatttttt ccttccaaat taatggaccc actgaaccac agttaagtct ctgacctagg 88620 ctaatttcaa agtatgaccc tgtctgaaca tagaaaaagt atttagatga cttctgctta 88680 ttttatcctt atgttttcac ctgaaaaatt acttttattt aaacattgat gagaaaatca 88740 tagacaaaaa taaggaagtc attaactgcc ttgtattttt aaaaaatgca agctacatag 88800 tggaaaacaa gcaaatactt aagaaaacaa acaaattatt ttttcttgaa aatcactaga 88860 aattttattc tagtgttaaa aatattattt ttttctttct gctggaaaat tcagtgagtt 88920 ataggggtat attcttttta acatttttga gataatattt tatatcatga attatttgta 88980 caatcaacct tcatcttagg caaatataac atcagttata tttagaataa tgtttagtta 89040 gaatataaaa tgcttttgta ttcataattc atatacatga ttgtaaatat taaaatattg 89100 ttatttatta taatatttaa tcaagcttaa aatgggaaaa tataaatgat caacttataa 89160 accatgtggg ctacaaatct gcaaataggt cctttacaac ttgcctacat atcaattatg 89220 agtttttaag aggtagagaa agcaatttgt aaaaaattct ttttaacatt tttgagataa 89280 tattttatat catgaattat ttgtacaatc aaccttcatc ttaggcaaat ataacatcag 89340 ttatatttag aataatggtt cagttagaat aatgtttact gtgatgtaca aaatacaaat 89400 tatggcaaaa aggtgacagc aggagaaaag ctagtgtgga atttaatata agcagaaaaa 89460 ggtaaattag taaattactt ctctaattta ttgtatttac cctttttata caacattctc 89520 ctagtagaac aatatataat aatatagtac tttggtgaaa aataactttg ctttataaag 89580 cacaacctga atttctactt ttattttaat ccattcttgg aaaaacatga ataacttcct 89640 cttaagggaa aggttaaata taatgttata tgagataaga aacccaagac atccagaaat 89700 ctgatgagcc taagtatcac accaatggac tcctatgctg tgaccatgct atgcttgtaa 89760 gagtgctcag gaaatagtcg gttgttgttg tcttggtttt tttaacttgg cctagaagtt 89820 gaatataagg gaactagtct tggcaaattc agagggggaa gaaaaaagcc agttaaattt 89880 taaaactgga gaattgaaaa tatgtattta ttataatatg aaaaatgaag aacagatatt 89940 caatgaggtt tcttcagatt tactgtattt tccatataaa tattgagagg cataactttc 90000 ttcccctctt gttcccacgt gtgagaattt gaacaaaaat aattccaagg tgagacattc 90060 ttccatgcac ccaaaaaacc tgtcaaacac aatttaaata cttttgaaaa ttaaataaat 90120 caaactgtct tacaatgtta aacatatcta ttaacttacc ctttaacttt tataaatggc 90180 ttaatgtaat tcttatacct ctgtaaatta tctctataat aggtgtatca tgtaagttca 90240 ttaattaaat ataaccttaa cttggaaaat gttttataat ttatattaat tcttttgcac 90300 acactttatg ggttatgtta attatctgac tcctaaaatc attttattca ttttaacatg 90360 aagctgatgc agttctaaaa tcatgttatt ctttaagtct atccagaatt gctaagtctt 90420 ttatttcttt tactatacag tatatgctaa aatttatcca gtttttttta ttttttaaat 90480 ttttgctccc atgatttttt tcttctctgt gagattaaaa gttaagttct agggccttct 90540 ctgtgctttc tgtctccctt cagggcacag caaagctgtt gttgactttc tctgtaactc 90600 attaatccat tgctaccttc ttgataggca ccacttgaag ctaatgccga tgtgtgttct 90660 gtggactcct tggctttgca aaggctgatt ttctgtcact aatgatttta aagttttcat 90720 ccttatctcc tccatgttaa tgtgttgaat ccagagttgt cattcctttt aattaatctg 90780 attaaccttc ctaggctatc taagtcccca gtgtaagttt tatgtttgaa atcagagaag 90840 ccccactttc caggttgtta gtagaataaa attgtttagt tattaaaaag atttacctat 90900 ttctattata gaatttattt cattttacct tcatgcttta cccaactctc agcaggaatg 90960 ttcttttcct ttcattcaat tcttattatc atctttaaat tttaatcatt tctatgctat 91020 gcattctttt aaaacccata gagacgtgct atactctatg aatttgccct tgagatgtat 91080 tgcttttggt attatctgtc atgtacttcc tgcccaacta taattcaagt gtcttggaga 91140 ttgactaact tgaggattgg ctgactcctt caatctttgg tcaaacgtca gctacttaac 91200 ataatttaca atttaaaatt atttgttaac ccctccccca gcacttgtca ttgctacatt 91260 cctgaacccc ttagtctgct gaatgtttta cacattactt ccataacatg ttatataatt 91320 tacttatgta ttatttttat tatgttgttg tttcagccta aattaggaca taagccccac 91380 aagagcagag atttttgttt attttgatca ctaatgtatt ctgtgaatct agaggagtat 91440 ctaatattta atttgcgctc cagaaatggt tactgaatga atgaatagta tctattttct 91500 gctttgtatc ccatttccat attccttaac atttagtgca gtgtgtttaa aaaaaaggtg 91560 atcgaaagtc ttaactgggt agatctccag tcaaaagaaa gagcaaaaga gagagaaaga 91620 aagaaaggaa agcagaggaa aagagaagaa aggggtggaa aatggagggg aggggagggg 91680 aggcaaagga agggaaaaag gaaagaaata taaccacttt gttctcagtc ctaaaagttt 91740 agaataagta cttgcttctg aaaactcttc agaaaaattc tcaggaactg agatattgtc 91800 ttctgtgctt ttcagtgcaa aagagaggaa ggaaggaagg aaggaaggaa ggaaggaagg 91860 aaggaaggaa ggaaggaagg aaaggaaagg gaagggaagg aaggaaggaa agggaaggaa 91920 ggaaggaagg aaagaaggga gggagggagg ggaaggggga ggggagggaa ggggagggga 91980 gggaggggag aggaggggag gggagggaga aggattaaag atatgtctgt taggtttggc 92040 tctgtggaat attgctttgt tagtttcata tctcctttgt tcggtggtca tcatctccat 92100 aatctttaga gtcattggaa agttatcaca gaagagaaca gcaacttgta aactaatatc 92160 agaagattca ttccattctg tctggcaaac ttaaattttg gaagaaaaac acttataagg 92220 aaggaaaaga atgtctgttt agccagttga atcaataaga ctactacatt tagataatgg 92280 taatgcatga ggagtcttct attttcattt catctttagt gccttggcat aggtatttta 92340 tattccacat gtacacacac aaaaaaaaat tgttcatcaa acagcttgac taggcactga 92400 aaaatgagaa actaaatgaa actagataag ggcataaaaa cttagtccat ctcatctcag 92460 tgaaagaact attgttctag atgaaaaata tgtgaaacat gaaaaattca acctggatat 92520 cacttggtag catatggaat tttaaaacta cagtgaagac acttaagaca catacacaga 92580 agccataaca aaaccctatg gtacaaagag ttctatattg tgttctgggt accccacagg 92640 atttccccaa gggctatgaa ataatgaggt cccaagagta tttgcctttc ccttctgcaa 92700 gtaagtctac ataaaccgtg tttagtgttt agtgcttttt aaagactttt cattgtaaaa 92760 tattcttatt tatctccaaa gattataatt tgaaagttca ccattagctt tggctctcag 92820 gtaaccattt ctgtaaacca taaaggggct gtaaaccata aaggggctgc caagaaagcc 92880 aagaataaaa aatcagaata agtatttgct cgtagtgaag gtaggcactt tatagacatt 92940 tgtgcatctt ccttctggac cactgtagaa agtactttaa gtagttctta tgagacactg 93000 ggtcatgata taaaacattt ttcctttaaa aatgttatat aagtattggg tgcatatgag 93060 tatcgaggat tccattctat aatagaagtc ataacatcaa actacctggt tagttttgct 93120 agctttcagt cgcagtgtgc tccattttac aggaagcctt taaattcaat ttatctggta 93180 gagtgatttc aattagcaag ccagtcttat accctcttga actagactat tgggtggaat 93240 attgagttca gttctgccta cacattcgct gtcactccac aaaatcccag ctgttcaact 93300 cacacccaac tagaatgtac aaacaacact ttttaaacac atcaacaaga agcaataaaa 93360 acataaccac ttgttctcag tagtaaaagt atagaatatg tacttgcttc tgaaaacact 93420 tggaaataat tcccaagaaa tgagatgctg ccttctgtcc ttttcagtgc taacagatca 93480 aagttcttga tggtttcttt tattattttt aactctcact gttgttaaac cctcaaaacc 93540 taacccccat ttaaataaag cttcttttta agattcacag ttttcttact cattcaactg 93600 ctgttcacac cagatggctt ttttgctacc atatttttaa gacttttttt tcttatctct 93660 tcatccagct ccttctccat tcaatggaat agtcagtctg ctacagtctg gagttgaagt 93720 ttaaaattct gaaaataaat gcattaagaa tattttatag gcagtttttg tatctttatc 93780 caacaaagtg attaagaatt ttcatacttt ttttcttctt tgctactttg actcctttat 93840 cactttcatg tggacataaa aatctagatt tttaattatc agtggctaaa aggatcattt 93900 aaaacttcat ggtaatccaa gaaagaggaa gaaaagaatc tctgctggtt tttttcctct 93960 tttatttcat cctgacaatt ttgaaaggct tcatggacaa ctcaagtttt aatttttaca 94020 atgctgtcat ttaaatttcc tgtgataatt atactatcca taagttttct ttgcagaaat 94080 aaaaataagc aaagatgatt tactcatagt ttacaccata tttactgtgt aaatttattg 94140 atattttatc tgactttgaa tttccatatc tgatttaggt ttacagcaga tttcattaaa 94200 ctttcaaaac cttagtgatt tcatgaaatt tgaattttga acaaatctgg gctgttcaag 94260 tgtgatttat tatgtcaggg aaaaaaaagt gtaaagtctg gcagtgtgag atgagttttg 94320 agtttgagtt ttctggttca tttaagccag aatctcagag aaaacctcta gggacaagaa 94380 cccacaggaa ctgtagctga attcactata aatattttaa agataaaaat actttctgac 94440 ctctaactaa aattcttttt tatatgttaa cactcaaaac attactgtcc aaatcattca 94500 tctttttaca ggctataatg acaaattact atttgagtat cttaaatttt accgtagcat 94560 tattaagaat gattctgctg caatccacag tgaattttgt aattattaaa cccattttcc 94620 acaatatcca tttccatatt tatatcaaag ttccagcttg aaaatctaaa aaccaatata 94680 tcaaaagaaa gggaggttaa aggaaaataa ttgttttata cttattttta aagatattca 94740 aatataggga ctacaacagt gacattttac cttagattta taataaataa agtttattag 94800 tttcattttg caaattcttc atatgtaaaa ataatagtct ttataaagtt acatcagttt 94860 cagtatcaat atgttagctg agctgggagg tagcaaactt tggcttagaa aaaaaaagca 94920 tgcaacacac tgaagtgctc cttaatactt ttttttcttt aaatctaaac atcaactggg 94980 aaaaagcaga aagatttttt ttaaaggaaa aaaatctaag acatatagaa ttgtagagat 95040 gttttatcta atacatgctt agaataaatt atatattacc tttttttaaa ttttggttgt 95100 cttaaattat gattaaacaa aaacacttca aaagtagaaa gtggtatact gccatatatt 95160 ttatactact atatttagta tcaagtttgt cctactggaa aatgtcttct gtggtgacta 95220 ttgatttttc caagaaaatt tatttaaaga aaggcaatag aagtcatgct tactatttct 95280 tgtttaaagg aaattgttat tgaaattatc tggtatgatt tttattttca aactaaaaga 95340 aaatctagat tagaaggctt aacctacatc acttcctaga tactctatgt aatgttcttt 95400 gtcatttatt tgctctaaat aacgggttct ttagtttaaa aaaaaagcct tcaggtaaag 95460 acatttattt tgtcaagctg ccgttataaa acctagatca aatgcagtaa acgagtagag 95520 gtaagtgagc ctcttttaag gtaaatgaag cttaaaacag aattgagatt gaatcgacaa 95580 atggctatgt caaattgctt catatttcat gattgtcaac cagacccctc tgtatgctct 95640 ctctggtctc taatgggcta gaagctctac tagtcaagtt cacaaaaagt caaggattaa 95700 tataaggata ttctcaaatt tcagtgtttt aatgtcttct aggtacaaag catcttagag 95760 aattttagct gcctgaatat cagtaggtag atatgcaaaa accaatgagc atgtctccaa 95820 cttctcttgc aaagtgtttg tttacttgta tgtgggaacc agccaaaaag ttaagtggtg 95880 tctgagtatc agcaggactg acacaccaat cttgtttctg gaatcacagg ttagagttgt 95940 aattaaaagt tctgtcggcc gggcgcggtg gctcacgcct gtaatcccag cactttggga 96000 ggccgaggcg ggcggatcac gaggtcagga gaccgagacc atcctggcta acatggtgaa 96060 accccatctc taataaaaaa tacaaaaaat tagccaggcg tggtggtggg cacttgtagt 96120 cccagctact cgggaggctg aggcaggaga atggcgtgaa cccgagaggc gaagcttgca 96180 gtaagcggag atcacgccac tgcattccag cctgggcgac agagcgagac tccgtatcaa 96240 aaaaaaaaaa aaaaaaaaaa gttctgtgaa ttagaatata actgtatgtg tagaactaaa 96300 cggtcaggac acagctaatg agaatgtggt tttgagaact aggtggaact gtgaatacct 96360 gcctggtagg gaagcttgtt tacctgggga gaacttaatt acagtgcatt taaggaaaaa 96420 taacagaacc atgagggaaa agaaaggctg ttgcttaatc ttaaaaggtt tttattgaca 96480 gcaattatac attttggaga aattatcaaa aattaacatt tgtttcatac aataaaaatg 96540 ctatcaagtt ctccttgaca atgagtattt tgggacaatt tatattgcat ttaacaaggt 96600 gggcccttat ggtcttttaa atcctctgtg atttgagaca taagtagtca gggcatgttt 96660 gtcagatttt ccataatctg acaaatggat atttttgcaa ggatgattta tttcctattt 96720 ctttattaat tgttctacct ccctaatgat ttctgggtca tcagcatttt cagggtatgg 96780 cgaatccatg cattatgtgg gatttgaagt agaaaactag tctctccctt ggtgtctgta 96840 aaatatcttg aaataaatcc atttcaccag aacttaaatg aatgtgaaat ttgctagata 96900 attttgtcaa ggtggttatt ccgttttacc cactagtatt atatatgaaa aaatatttta 96960 aaatatatta tttctcttta gatgcatttc ttgataatgt gtcataattc ttactctgtg 97020 attaaggttt ttatgagtaa ccaaggaact ggtgttcgag agtggcataa tttaaatttt 97080 aaggacatct ttacaatcag tctttcttat ttttattgta tttgttgtca ttgttgacaa 97140 tttgctctag actactgaaa ttttatcttt taacaatgtc cattgattta cagagccact 97200 gcattgaaac attttatgta cctctaattt ttaataccag aaatatgata aatctggtat 97260 tctatgttcc gtgaccctac attttgattc cagttcttaa ccaagtttta cttctgttag 97320 taagtttgtg ctctgtaatt ttttcatttt ttctttggta acattctaca ttatttaata 97380 taattttgac tttgaaaata gcctctggtt tgtcactttt atttaatctt aaatgcattc 97440 atcttttatt ttctttctct ttctttcctc ccttttttta cttactgtta ccacttagaa 97500 attgctcttt ctgaagcttt tttaaaatta ataatttatt tattttttga acaaatgcac 97560 aaggcacaca attcaaaatg ctaaaaacgg tatgcaaaaa ggctgtcacc tctggccatt 97620 cagttccact tgccagaagt taacatggta accagttaca gagagagatg cagatggtag 97680 actctgtcat acagaggtat atagcaacta acagggagag cgtgggttga gagggaaatc 97740 aatgaaataa gaagcagcag caactagtga gagactcaca gaagggaagc ctgagcacca 97800 aatatggctg acaattagag tttctgctgg gtccccataa cctgtgtcag gttactgaaa 97860 gcaaagaata acattctagt ttacctaaaa cctgaatgta ttacttctga aacagttctt 97920 attcttctgt actttttatc ttgatttaaa acaaaagaaa acaaaaaaaa tccttccact 97980 acctgaattg gagcatgtct ctaatttttg tcacaagagc cgttaacata tgtcacaagc 98040 aagatatgta tctttgctaa acttcaagag taccatctat atcataggga ggtctcttgc 98100 tctcttcctt cttctcttct gtagtagaaa gttaatactg taatgcagag tgaaaaggat 98160 aaggcctaaa gtgaaaatat ctgtactgtt ttaaacatac aattagttga attgcagata 98220 atttgcctaa cattattatg ttttctctga ataaatattt ttaaaacttt tagttctcaa 98280 gagaaaaaag aaaatataaa gcattcaatt tttattaagg aatgaaatat aaaaagtgta 98340 atgtgcaaaa acatagatat cagaatggat taaatatgcc aaatatattt atatcaacag 98400 tagattcaag tgaacattta acttctaata ataagaaaaa gtattttatt ttatagccaa 98460 tgaagaaaca aaaggaaaaa ttaagaaagg aagtgagggg aagcccattt tacaaccact 98520 ccattaacaa atataaaatc aaagagaaaa aaataaatta aaagataaat taaaccaact 98580 cttcgtgtca ttcttatgac acccattgct ctagatcatt tccaggtcac atggatctta 98640 actatccata ccactcctac ttctgggtta tttcattcct taaaactgtg tttctggtag 98700 aatcaacaag gcaaatatct agagatgtgg tcttcaggtg cagaactttt gatgtcttaa 98760 tttgtaccta aaatcatctc ctgctcttaa agacatttgt tattctccat gcaagctttg 98820 gaacactgat tatcccacat caagtgataa aataaatata ttttcaaaac aaagtatgaa 98880 gaaatccagc cattctatgc atctataaat ctattcacag gaaacatgac tgctttaaag 98940 aaaataaatt atattaactt caagaaaacg agacatttta acatttaaaa agtttcagta 99000 tcttatgtat atctcacatt gcttcataaa aatgactgta tattttgtaa agggttctaa 99060 tgatgtagga aagtgccttg agaaatacag tgttttataa aactctacat aaacataaaa 99120 taccattatg tttatgtttt gaactgctag ttattcatat ttcttaaaag ggaaatatta 99180 aacattataa aagctgacat gttcatactt gacatgtaga acctgcaatc aattaccagg 99240 ctgttgacta aaatggaatt acaaaaattt atgagcatgc tggtaaaaca gttgtgatag 99300 atggataaaa tatttaatat gtagcacata gcatgtaaca tcaaatcata tataatacaa 99360 tggtatataa cattgtatag tataataatg taaaatatac atgacaactc tattacaaaa 99420 tgcttttgct ctcatttttt gctttgcttt ttaatttaac atgaaaatag catgttatta 99480 atatgtataa ttaataacat atgttattaa tatgtgtaat taataacata tgttattaat 99540 atgtataact aataacatat gttattaata tgtataacta ataacatatg ttattaatat 99600 gtataactaa taacatgtta ttaatatgta taattaataa catatgttat taatatgtat 99660 aatgctagca tatcactatg ccatgacatg aaactaaata cccctctcca aagcatggct 99720 ttaattttat acttagaaga ctaggttaag ttgtatctgg atctgcataa cagttagtca 99780 attatcatgt atttctgaag cctatatcat agcaagattt ttgaatcaag attcatagag 99840 aactcctaat aaacactagg aaaaatccaa gtccttgaga tgacaacaaa cccacataga 99900 gaaaactacc aaacccagaa agtccgaaaa agtactttag aggtacacac tgaccataag 99960 atccatagca tttccaatga cttggcaggg cctggaatgg taatgggaag aggaaaggaa 100020 attgcagttg agggactaga gcaaagtcac agagatggaa agagcagaaa gttcaaggag 100080 tgttattaga tggcattccc tgatgtagag tggaaggtaa ctgttgaaga tctggccagg 100140 aattaagaga acttggacct gctgtaagat tgacaggctg agtacaccag tctcaggatt 100200 caaatttgat ttctattgaa acatcattac cgttgttgag cacggtatga ctgtaataaa 100260 gttttctgta ttctgtgcct ttctctttaa ttcgatgtac tcctgaatct tgcctgcaga 100320 cacaaactca cttccctcca gtctttgagg caggtcagcc tacccaccca ctcccatctg 100380 gtgctgattg gaagccacct gagttaccaa acttgtcagt gcctgttgtg cctggaagaa 100440 gccgtgggct cactttggcc tttcactcac aatgcttcct aactcctaga caatacctgc 100500 tttattagct gcctaatgcc tcaggtttac ctaagactag gacattgctc cagacccatt 100560 tttgtattaa gtctttgcct cctttgaata tttgactcct actttttctt caccccacct 100620 tattccaaca catacatacc tggtgtccac ctcctggctc gggtcctgac acaaaaggat 100680 ggttttacct gagcaatgat aacttaacat tatcatcttt cactgattca tcagtgcttt 100740 taagtaccag gcatggaact agaaccaccc caggtactga catgtcacac ctgtctgtta 100800 cttctgacat agtggcctct tggggcactg gtctgtgaac tacttggctc ctcttatttg 100860 gattagtttc tgcaatccaa ttaattctcc ccatttacag tgctttaatg agtaataact 100920 tggactcaat caatacccag ccctgctcat tcatgtactg ccatcctaat atccatatct 100980 cattgatgtg tcttttctta ctaggtctga atgatcatat ctttcaatgt ggctattgac 101040 cttgtatttc tcatagtaga atcagatagg aggaatatta tggggcctgg gactctaacc 101100 acccctatgg ccagaccaag ctacatggaa atattttgag gagaccctcc caatgatcag 101160 gtctcactca ggaacatgcc tggcctggga tggctcactg caggtcccag cctctaaggg 101220 agacagaaaa atcctgggga ggttcacctg atgactgggc cccatgtagg acctggagca 101280 atgtattcca gaggccagca acagctcagc atggttccca ctggtgtgga tatggaagca 101340 gttagtagag gtgcaaaacc agcaggtaga aaagacatgg tgccccagtg ataaggcaaa 101400 aacaaagaac attcaggtgg ggtggctggc aatgtgtcag atgaggtatc taagaatcca 101460 tggcgacaac aatcagaaat gagagtagac agttgacatt aggaataaca tcagctggga 101520 ggtagtcctt ggccatttag caggaatttg aagcatggtg ttcctagccc tcaagactag 101580 ggtgaatata gtgagaagga aagttagagt aagagtagaa caggcataca agggaggttt 101640 tgagaaaagt aattgaaaat gggcaccaag gcagaagctc atttataaga tatggggcac 101700 acagggggca tctgaggctc ccaaagaaga tgggcatcag tatttcagaa gggcctgaat 101760 gacagtaggc aaggggaact caggagaagt tgagctcccg cacaggttgt gattagcaca 101820 ctgaagaaga agcagagcag gtgtgtcaga gtggggatcc agtgcggaag gatcatgaac 101880 tagaaattag gctgagtctg acttagactt catgaaaatg atgccctgcc tataaaaaac 101940 ataaactgca acagagttta gcatggatat gggtggaggc atataggcaa ctttattgtc 102000 gagctctcaa gagagagatt ccaattacaa tgtattaaat gctgttttat atttatttct 102060 tttagttatc ctccaaggag cccagatgaa gtaggtgtta gccaatttta tggattaatc 102120 tcagtaagga taagaaattg cttaacagcc agacagatac cagaataaag gacaaacaca 102180 ctgattttct ttttttgagc ttttgtccaa tgtgctctat cagcatcaac tcagttccag 102240 tgtttcctgt gggtctcttg ttttctggga agaagtaggt cagattaggc aacattcaat 102300 atgaagctgt acctcctgac tgagtctgaa agcctctgtc agcaagttct ggagaaccct 102360 gattaaatga aaccaccaag gtgaacttgt cttttgaaaa atgtcaaatt agggcagtga 102420 cgatcttaat gtataagggc tatgctcctc tgtgctgaag aactctggca gagacttctt 102480 ggtagtcaac aagggtaggt cgtcatgagc ttactcaatg gcagttatac acagagggag 102540 tagggtcttt gcatgcaagg agtaacagga cattcatgtg tatatacata cacacatata 102600 tatatgcaca cacacatatc atcagaacat gaccaatgac ttgactatta tcttttaaga 102660 ttagaatttt taaaagaaac ttacacagaa agattctatc ttgttgtagc aaaaagtaga 102720 gctgttcttt tttcacaact tttttttttt tttttttttt tttgatatga agtcttcctc 102780 tctctgccgc ccaggctgga gtgcagtggt gtgatctcag ctcactgcaa cctctgcctc 102840 ccgtttcaag tgattctcct gcctcagctt ccaaagtagc tgggattata ggcatgcgcc 102900 accatacgtg gctaattttt gtatttttag tagagatggg atttcaccat gttagccagg 102960 ttgctctccc acccctgacc tcaagtgatc cacccacctc tacctcccaa agtgctggga 103020 ttacaggcgt gagctaccac acccagcctt tcacaactat tttcaaatgc caggctgtat 103080 catcctgtgc ttggcccact ttaccttaca gcaggggact gtacttaata gtggagaaac 103140 caaaattgtt ttggactcag taaagtgttt gtgatttact ttgaacatta ttatttttgt 103200 ctattagtca ttaatataat tttcctgaaa tacaatatgt gatttggaag gccttatttt 103260 agtcttcttg catatatatt ccttaagagg ggtcttattt atttcaatat atatagctaa 103320 agttctatat tttatcttgc acccaaatga tagcagaacc ttgactcttt cctcaaatat 103380 ttctgagaat gcttggaata ctggaatact ctcactgtca ctctgccttg gtctccatgt 103440 ctcctgtcct ctttctgaaa acacaaggct ccttctggcc ttgtgttttg caaggctact 103500 ctctctcttc tgatctataa gcatgaacag ggtcctctct gaacccatta gcagctgctt 103560 ctcttagagc ttacgagccc ttacctactg ctcttggccc ccatttaact caaggcagag 103620 aaagccaact catacagacc aggatcacta gccccagagg tgcttggaac taccctttct 103680 gtaagcaggt ggaaatgggc ttcatgcttc actgagaagt tgtacacatg atcctcttag 103740 agtttaggag aagatcaaaa tctcagtctt ttttgagatt ttctttctct cttagttaga 103800 gtttggagtg tgttatttcc agaaccatag tccttacttt gtttttgttt attttaggtg 103860 cctcgatcta tgaatataat tgggtaataa aaagaatata cttccccagt aaagctactt 103920 tagttgctga atcctcagga aaaaaaaagt tattttttaa gggtttaatt gctagtcatt 103980 gtgcagaacc acagtaaaga taactacata atcttacaga agtggcctta cagtgggttc 104040 attttcttta gaaagctcca ttgcctcttg ctgtcattct tcaaattctg agggtactgc 104100 ttgatgctct ctatcttcct ctgattaacc attacaacag tccaacaccc atttgtcctt 104160 ttgtgacttt ggtcacctca taaattgcag caatccctgt tattagaagg catcacatca 104220 cctataatag gtgagctgta tgaatgtccc ttagccacaa tgaatcattt acctttgggg 104280 taatttccaa tcagcaacat catcctcaat ctataatctc tcacttttgc tttataaaag 104340 caaatcacct tcagtcattt cttatacaaa acactcttcc ttaaaaggca ctattttgat 104400 gtaaatcata tctgatggga atcacaaagg catcaacatc cacaggtttc cagatttttg 104460 aagctccttt gtaatgagtg aaaaatttag agttcttaaa ataatacatg caaaaacata 104520 actttaattt cagttatttt tctataatca catttaattt tggttatggg attccattct 104580 attcaaaaag caactcattg catgagaagt tttcttagtc caaacaggat ttttagtcag 104640 tgtgccaatc cttctcttct ccttgcaggt ttgccagtgg actcagggag aaagacctag 104700 tcctgagtcc tcaccacctg gccaggttgg catcagttaa caggaaaagc attcactgat 104760 tttttattat atgtattatt attcatcatc aacatcagtt ccaccagaca ttacctaaac 104820 tgtccattcc attcatggtc aagtcattgg cccatacaag tacttcaaca ttcaattatc 104880 ttgaccatga ggctctgctg gccttctctc agctaactct aagcccttct caaggagcat 104940 attatgtgtg taaaattgtc acagcttgac gggctgttct tgcccattgc tcagaaaagc 105000 caatgcactg agaacagcaa gtattgtaat aaagaaagag tttaataatc gcatggccac 105060 ccgagtgaag gataagaggt atttctcaaa tctgcctccc taagaatttg gagattaggc 105120 tttttaaggg taattttgtg agcagaaggc tgaggaactg gggaactaaa atatttggct 105180 ggggatgaaa tcacagaaat gtctaaactg tcttagcaca gtttgagcca cttcccagga 105240 ggaggtttca ggacaaggta gaaggtttac caaaatacta aatctgcaaa atacctcaag 105300 ggccaattct ttaaagtttg caatagtgac attatctata ggagtagttg gggaagttat 105360 aaatcttgtc acttctggtt atgtgactct ggtgccataa gcaacttata ggaaagcaag 105420 caaagcaatg gcaggttatt ttttaactat gcttattctt tagcaggatt caagctccta 105480 ttataatttt aaccttgtca tgtgaatgtg gcttcactct ccgaacaagg agagggttca 105540 atttcctttg cctcagagtt tatgaagtga attcctctca tagctttctt ggccttcata 105600 ctagagtaac caaaaacaaa ttcagcttct gagattagaa gcaagatgga gtcactcata 105660 ttagatttct ctcattactt ataattctcc aaaggcagtt tcaaagtgat tggtgagcag 105720 tgtgtcttgc atgtctagac agatcatagc cattgcttac tttttcacat cctgtgaaac 105780 ttactgtaag ccttgtcgtg tcccagggag gaagagacag gttctgctgg cttttagatc 105840 accagattac taggcttgga tgcaaggcag aataagaaac aggattcaaa atttcttttc 105900 aaagactccc atcaacatct aagtttgttg ctttcatttg tgattccttt cctttaacac 105960 cactctctcc agtccctatt ttcatatgtt aaaaggattg gcaagaaaaa tcactgtcaa 106020 gtaatcagat gtttttctat gactatgctt tatggtataa acttcatgta ttgagtccta 106080 ctgagctctg gcttttaata tttaaagcca tggttttgaa attaaaaaaa aaaatgctct 106140 ccaatgattt atgccatgag tttgaaaagt ccattttgaa acacaaaaca ctcaattttt 106200 gtttaaaaat ctgtacctaa ggcaaggagt gccacactat ctttctggga ggaagggctt 106260 tcatgttgaa gagaatcatg gtggaaaaaa acagcataat gtttcaaaat acatcccatc 106320 atatatgggc aggaaaaacg caatatcgac aaaaagtgag agctgacacc atgtcgcttt 106380 agtgcttgca gatgaagaca ttacataaaa ttaacatcta tgatcactat aatttctcat 106440 taaaaattgt tataaaaaca taaaaaggtc ataatctaaa aacaaagcat agttctctaa 106500 attgttaatt cttttacaga taatatgcag cattataaaa aaagagagag ccaccatatt 106560 ttcctataca tagtatttat ctttgttcca ggagggaaaa aaataaattt tatcatgtga 106620 tatcccagat tcatgaagga attactattt ctactcaaaa atgctaccat attattatgt 106680 agagcttttt gaataagact tcctagaatc cacaatttaa taatggaatg agtttagaaa 106740 aaaaaaacat aaattttgga ccaaaaaata tatccattca aattatagtc actgccagtt 106800 atttaaattt ctgagcctca atttacttat ttgaaaactg gggaaagcag taactataca 106860 tttaagtaat gctggtggtt taaatgaggt aaagtatgaa aaatacctgg tacatggtga 106920 gacttcagtt aatattaatt tacattcaat ttactctaga tgacaaacta aggaggaaat 106980 atttatacca ttttacataa caagtggata tttctatctt gttctattca cttccctttc 107040 ttaaaaaaaa atcaggttca gatcactgga tcaaatgctc cttcttttta ggcaggcagg 107100 agattgctgc tgatggctga caaaataaaa tgccaaagga gctgaaaaga tgcatgggtt 107160 agcttaggct aagttctgct gtgatggaaa atgataccaa agtctcagag gctcacaata 107220 acaatcactt ttggctcatg ctacatgcac gtcatgagtc tgtttcagca ctgctttgta 107280 ttatctttgt tctgagaata gactagaaga tcatccccca tctggggaaa tcctgatccc 107340 ttggctgagg gaaaaataca gaaggcagat ttacatgatg gctcttactg cttctgctta 107400 gatgtggtat atttcccagt tcattagcca aagcaagtta tgtggccaag cttgatgtca 107460 atgagttggg cagaaacaat cctgcaatag ggaggggttt aacaaatatt ttgaacaata 107520 atgtaatcta catgggctaa agtaatacgt ttaaagaaga caaaatatag acaatagaga 107580 atctgggaac gatccatgct aactactcag ctctagttta tttgctttca cacaggattg 107640 gcaacctagt caccaaacct gttttttcaa agaagctggg agctgatgat tgtcgattca 107700 tagctctgag agccaagccc acttcctgga aagtcctggc cccagagctc taataccatg 107760 tgtagtataa gaatttatat cagatctgaa aggaatggac tcccactgtt gctaaatatg 107820 ccaaattttc gagacaagct ctgaatctgg aattttatat aaaatctttg tatttcaaat 107880 gttatcaatg aattcaagta ttttaaaaca aagtgccaga ttaacaaaac attgtttcag 107940 gcaaaatctg gctcactgac cacagtttct gaataatgat ggaggtgtag aaagagatac 108000 ccacactttc ctgaatcagc agcttacaag tgggagaaat ttctatttct aacaggcata 108060 acaaaagtac ccaaaacttg taaagagcta ctgcccatat ctcatcatgc tattcaaacc 108120 tcacagtaat cctttgagac agatattaac aattataatt ttactattac aaatgaggat 108180 attgaggttc aaagaagcag tgacttgctg atgtgagtgc accttataat tgaaaatgca 108240 gaccacagga ttctcaattc tatcttcctt ccattgtacc ttgcattcag tttagttcta 108300 cctaccaaat ccctaaaatg tgacttttaa aacactctat ctttaatcag taactggata 108360 aatgtgaaac gctccttatc catatgaata tactaactct aaggtagtat accttttgaa 108420 gaaagagatc aaagaataag atatctatat attgggtacc tgcttaactt actttcagtt 108480 tccttttcta tataaaacct tttggtttca caggtccttg atcattggtg gcattctcat 108540 tcacagtctg catcagaggc tgtcacgtca tgagtcgaat gtccccttaa ctactaatat 108600 cagctcagga gatactttgc tacagaaaag ggagaagagt attgccatcc tcttcacacg 108660 tagtccctct aaatcgtcct agaatttgcc cactgccagt gcatcttgct ccctacacca 108720 ctctggacag tgatatccct atggccacag aggagagcaa ggtatcccta gacagcccct 108780 tcaacatctg cctagtgtct gtagttgctt actgttaact tactttgcca tttagctgaa 108840 aactcaagtg ccttaattct gccaacttta tctgccagga gttaacagtt caagtttcta 108900 agcccacagg cttcttctta tatttatatt tttgtaatta gtaaatattt caaacacaga 108960 aagtaatata attgatatcc ctatacctac catccagctt tactaaattt aacttttgct 109020 gcaattattt cagtttttaa atatactccc tctaattgta ttcctctgcc ctctataaag 109080 ttataacctt ttcagacgta tctgcaaccc taaatttagt atagatcatt ttcataaata 109140 tttatgtgct ttcataaata ttttatattt tcataaatat tttcatggat atttcatagc 109200 aaatatccat aaaaataagg tatcatattg cttgttttat aaaatattat aaaatagctc 109260 tactttctgc actgtgaact tcttgatcac tatttgttta ttcaccccaa attaatacct 109320 gtagcacaag ttcatttatt ttaattactg tataggagtc aatagaatga atatacaagg 109380 attgcttagt caatattctg tttataggca tttaggtttt cttttttacc ttttattttc 109440 ttttagttca atatttcaaa caaagttata gaagcagttc cttatgcaca tgtgcaaaaa 109500 tttttttgtg tatatcaatt agaagtggaa ttgctgtgct ataaatttta ctaatattat 109560 atattattat atataatatt atacacacac acacacacat atatatatat atgtatgtat 109620 gcaggacatg aatcctttaa gagtcaaaat gcattgcaga aggtcttctc aagtctctac 109680 tttatttttt ccatgttact tatgattttg ttttcttttt ctgatagaga tgtttctact 109740 gttgtcagct ttccccaact gtttctctta cattttgcat ctcatttaag aaatcctttt 109800 gctctgataa aataaagatt ttttctctta tactttgtta tatattttaa ttttcatatt 109860 aggtcaataa ttcactgcaa ttcaagtttg tgtatattat aaggatagat ccaattttag 109920 tttagcttgc ctgcctgccc tttctgtttt ctttctgctt tcctttcttc tttattttga 109980 taaccagttg tctcatcact tttaattttg ttgaagattt ttgtatccat gttcatgaat 110040 gacactggaa catattttcc tttttcccgc tgatattgtt ttgtttttat atcaagttta 110100 tactagaatg attaggtgaa tcagtgagtt tcttgatttc tagtgtctgc tatgctttat 110160 gtaagattgg taaaaactgc ctatcacacc acatgagtat tattggccag ttttggaggg 110220 aggatatttg gaaaggaaca gtttttaacc tgttacttcc attgtcttaa ttgtcatttg 110280 ttattcagat ttgtaatcta ttttcttgtt agtaatatta aaatgtcaat atagaaattt 110340 ataatagtat tctttaatga tttattaaat tgcttgtctt tagttttgag tctttcactt 110400 ctaatactat ttgtgcattt cctagttttg ttgatttccc atttaggaaa tgcagtttca 110460 taacaaagta tctagtatgt aatttttaat taatcttgct tgaaatttct tttacttata 110520 aacctgagaa ttcatgtttc acaagaattc tgggaaaccc tcaatcataa gcattttcaa 110580 tattgactct tttccattct attaattctt tctagtattc ttactagata tattttggat 110640 ccatggttct taatttctct ttcatatttt tcatcttttt tcattcgaca tcttctagtt 110700 ttctaatttg gccatgtcta atataatgtt taaaccattc tttttttttt acttttatta 110760 ctgtaatata attttcacac tttgtattta catatttttt aagatcaacc ctgttcaaat 110820 taacttgctt ttttatgttt tcaatttctt attctatatg tgatataatt aaagctactt 110880 attttataga cttgatttta ttgctaaata ggaaaaccat atgatcatct caggagatga 110940 agaaaaaaaa ttttcacaaa ataattcaac acacacccag catgaaaacc aaccaataga 111000 acagtaacca tatttgtaga aaacggccaa taaaacagta ttttctcaaa ctttaggaca 111060 ccttaaaata cagcttatta ataacatcac atctcatgag gaaagactga atacttcccc 111120 ccaaaatgaa aataaagcaa gaatgtccac tcttattact tatagtcagc attttattga 111180 aggcactata ctagttttaa aagcatggaa aaagaaatta aaagtatgca ggttggaaag 111240 taagaagtaa gattgtctgt atacacaaat gataaaaaag ttactagaac taattaatga 111300 ggttaccaaa tctgttgaaa ccagatcaat tttcaaatat caattgacaa gctgattcta 111360 agatgtatat gggaatagaa aagatgtagc ttaactaaaa caactatgga aaaagaaaaa 111420 aagaaaaaca aaattggggg acatatatta cttgatttca aatttgacta aaaagtcaaa 111480 atagggtata ttcagagaaa attagccggg cgtggtgtcg ggcgcctgta gtcccagctc 111540 tcagggaagg ctgaggcagg agaatggcgg gaacccggga ggtggagctt gcagtgagct 111600 gagatcgcgc cactgcactc cagcctgggc gagagagcga gactctgtct caaaaaaaaa 111660 aaaaaaaaaa aatttgggta tattgacaaa atgacaatca tatagatcga tgaaacagta 111720 tagagtcgag agacagatgt acatatatat gggccaaggt aatgtaatag gggaagggca 111780 gtcttttaaa caaatggcgc tgtaacagtt acatatcttt gtttaaaaaa ataaaaaaaa 111840 aaacttgaac cttacttcac atcatgtaca ctaactcaaa atagatcatt gatctaagta 111900 tgacaggtaa aactataaat tttacatgaa atcttggaga aattttcata cttttgcatt 111960 aagcaaagat gttcaaaata agaccaaaat taccatgaat tttaaaataa tatttgataa 112020 cttggcttca tcaaagtttt ttgttttgtt ttgttttgag atggagtttc actcttgttg 112080 cccaggctgg agtacaatgg cgcaatcttg gctcaccaca acctctgcct cctgggttca 112140 agctattctc ctgcctcagc cttgcaagta gctaggatta caggcgtgca cctccaagcc 112200 cggctaattt tgtagtttta gtagagacag ggtttctccg tgttggtgca ggctggtctc 112260 gaactcctga cctcaggtga tccgcctgcc ttggcctccc aaagtgctgg gattacaggc 112320 atgagccacc gcgcctggcc tcatcaaagt tttaaacttc tgctcttctg aaagacacta 112380 tcaagaaaat aaaaagacaa gacacctact gggaaaaata tttggaaaac atatttctaa 112440 taaaacttga acccaaaata tataaagaaa atataaaaaa caccactcaa acagcttcat 112500 tttacaggca aaatctttgt agagacattt caccaaagaa gaatacaaat ggtaaaacag 112560 cacataaaaa atttatcaag atcattagtc attagagaaa ttcaacttaa aatcacagtg 112620 ataaaccact acttacgttt tagaatgcct aattaaaaaa aaaaagctga ttaagtccaa 112680 atgttggaaa gtgagtgtat caactagagc tgtcatatac tgctgatgaa aatggaaaaa 112740 aaaggagttt ttaaaataaa attaattatt cacatatcat atgacacaga aattcctctc 112800 ctgggtattc tcccaagaga aatgaaaaca tatgtactca tgaacatata tatatgcaca 112860 ttcaatatat gtatgttgtt tacagtgagt agcttttgca tatattttgc taaacttatc 112920 ctaaaaaaat cctttcatac attggtgcta aaatttcaat ttttgttcat tcctggtatt 112980 aagaagttca actgatattt ggaaatagat cttggtttca acatatacct acattcatag 113040 atatatgaat tgttatagtg aatatattaa tagccaaaac cttggaaaca gcccaagtgt 113100 tcatcaacaa gaaagtatgt aaacaaactg ttctatatcc ataaaatgga atactattga 113160 gctactaaaa ggagacagta acaacatgga tgaatcctaa aaacatcctg ctgagggaat 113220 agaggagaaa aaacattact ctgtaaataa tagtcagtag tattctatgt atatggaatt 113280 ctttaaaaag taaaactgta gtaacaaagt acatcaatga acgtctggga gtatgggtag 113340 agtggggtga cgaagatcaa ctacaaaaag atgtaaggga aattgcatgg tgatgatttt 113400 tatattgatt atgtagagtt taaacctatg tcaaaactgt aacaaatggg tcaatattat 113460 tccatgttaa ttatatttta ttaacatgaa tttaaaaaca gaaataattt tgttatacat 113520 ctctattatg ttgtgccctg agacaaaaaa atcttaataa aaaatcttaa actgttttat 113580 ataagcatat tttatcagta acatcactct tgttattcta agaattttgt atgtatacat 113640 agtagagagc ataaaagcta ttaagctgtc cttggaaacc aggacttttg gagtagatta 113700 tgggagaaag agacatagat aggtatgttt aagtaaaaac tctgtagtgc taaatttgaa 113760 taaaaagtat ctgtatgaat gcatgatatt ttgatcttta aagaaaaaca accctatcta 113820 ctgaaaaaca agtcctaaaa gtaaaaactg attcagctgc agtgataagc cccctcccca 113880 ataattacat tgtagttctt atgtaccact tcccattaga atgaatcagt gttccttggg 113940 aaaatagctg accactcagg tctagggtgg caaatgaaca tagagcccag aatgtcgtat 114000 cagaaagtaa ggaaactatt aaagccatta agaacatgtc aaaagatact gaagccaatt 114060 gaaaagcctt ccacacacca aaaatggggc aatttgacca ttaaaaaaga ataataggct 114120 gggtgccatg tctcacggct gttatcctgg cacttgacaa ggccgaggtg ggcggatcac 114180 ttgaggttag gagttcaaga ccagactggc caacacggtg aaaccttgtc tttactaaaa 114240 atacaaaaat tagctgggcg tggtggcagg cacctgtaat cccagcttct caggaggctg 114300 agggaggaga atcacttgaa tccgggaggc gggggttaca gtgagccgag atggcgccac 114360 tgcacttcag tctgggagac agggcaagac tccatctcaa aaataataat agtcataata 114420 ataacctcca agattaaaac ccttgaaata tgtatatgag tttataataa tacttgtaaa 114480 aattcattgt tactcttcaa ggaaaccaac tcattctttt taaaattggc aagtaaaggg 114540 aaataaacac ttaccttatt tggtatctga ggataaccat cagcaaaact tacactgcag 114600 aaaaccctac agaacaaatg acccagttta aaatactgtt taaaatatat aaaaagaaag 114660 aaaaatagag gtaggcttag tgtatagatc aaaattatag atgaaaattt ataggtaaaa 114720 atctatagat caaaagagat aaggtatgtt tctactaaat gcaatgagtg gactagtgtc 114780 ccaatttaaa caatttttta aaaatcagag aaatttttgt attgattggc taatatttaa 114840 aagcatgata ataaaatcgt gactgtgcat ttgttttgaa agaaaatatt cttttagaaa 114900 tacatgctga aatatgtgca gatgacatga tacggtatct ggaatttgct atgaaaaatc 114960 tgaagcatgg gggatgtagg taagggtgaa aatgaaagtt acccatgagt tgataattat 115020 gtaagctgag tgttttctac atggggtgtt tttactctat tttctcttat tgtgaataga 115080 ttcaaaattt tccacaacaa aaaagtttca taatgtccct ctgggcaaaa tcacttgtgg 115140 aagaaaacag acaagaccta gataggagtg attaaagaaa caaaacaaaa taaaacaaaa 115200 gcttgccttc tcccttttga tggtcttgtt catgaataac ttcccagtgc ttctattatt 115260 ctagtatagt gagaagagat tgagtaagac aagataatta aacttcagat aatatagagt 115320 acctttggta aaaagactgc atgaaagttg tatgaacata ttctgaatgt atcttccaga 115380 atgcttgcag ttaccctatg attaaagatt tttggttata attatgtatt ttaaaagaaa 115440 aattctgccc taaagaacat tcactataaa atgtaagcag acatggtgat aaatgtttct 115500 ttttacaatt taaacataat ttgcaaaaaa aaattaagga agactttttt atcaatgtga 115560 tactatttat actgtttatt aaacagttac aataggaata tgattaattg catataatca 115620 aagtgaatat aaagtatagg aatgagtatt acgaataaca aatttgtgtt tgcattattc 115680 aaattcaaag ttgtaactaa atcttatcca aaatatttga aataatcttc tttgattcta 115740 aacaccattg aattgagaaa accacagtta tagctaaaat ttgacttacg aactttcttt 115800 ttcaaattac agaaatattc tcatcagcaa gctgttggct gatgtgacct tagcttttca 115860 gaagacattc caaaaataaa acacacttca gtgagtcatg agaaaaagta tttttcgggg 115920 atactgcata ggatttaagg aagtaacctt ttcctttgat gcagtaagtt gctataatat 115980 ctatttgact atacagtagt cctttcttag ccatggtttt ctttcctctg gtttcagtta 116040 tccgtagtca accatggttt gaaaataggt gggtatagta cagtacaaga tattttgaga 116100 gagagaggaa gagagagatc acatttctat aaattttatt acagtatatt cttttttttt 116160 ttttgagacg gagtctcgct ctgtcgccca ggctggagtg cagtggcggg atctcggctc 116220 actgcaagct ccgcctcccg ggttcacgcc attctcctgc ctcagcctcc caagtagctg 116280 ggactacagg cgcccgccac tacgcccggc taattttttg tatttttagt agagacgggg 116340 tttcaccttt ttagccggga tggtctcaat ctcctgacct cgtgatccgc ccgcctcggc 116400 ctcccaaagt gctgggatta caggcgtgag ccaccgcgcc cggcctacag tatattctta 116460 tgtttattct attttgttat tgttaatatt ttactgtgcc taatttataa attcaacttt 116520 atcataggta tgtatgtata ggaaaaaata tatagaaata attggcactt tctgtggttt 116580 taagtattca ttaggggtct cagaacatat tcctggcaga taattggagg ctactgtatt 116640 cattgttaag actatgaggt gcgcacacac aaacacacac atacacagag taggttaaat 116700 tatgttaaca ggtctagaaa attaactatc attctaaact aaaaagatat tagacaggct 116760 gaagttatac ctcattatta cctgttactc caaagttgtt gttttgctct aactcgtttt 116820 ccaaattcac aacataaact gcaggtatta gaaaactttt cattctaact ctttcaacca 116880 ataattttat tgtcaaattc atcttcccag gaaaatataa caataaccta tatttgaaac 116940 tgtgtatatt ggtccttagt tatgattgta gccttcatag ttctggcccc aaaagtaagg 117000 tattaatgtg cttttatata ctgtatactt tttaaaagaa ttcctcacca cctgtgggta 117060 acaagatatt ctttgaaaat tattttttca taactatact tttacctctt acatttgggt 117120 tttaaatata tttgaatttc cctcatatat gtacaaaaaa agaaactgaa gtataaagat 117180 tgaaaagttg atcaacattg ggatttataa acagtgtgac tctatagaaa aatgaataga 117240 attaacaatt agagttagta ggataggtta gcaaagttgc taaagttaaa ctgagcaaaa 117300 ataatatggt agccccctgc cttcatcatt gggtggtaca ttccaagatt tatcctggtt 117360 gtcatgtgtg gcagggattc cttcttcttt ctggctgaat aatatttctt tgtataccac 117420 attttcttta ttcattcatc tgttactgga tatcccttca attggcaatg tacatgcaca 117480 actccagaga agaaacatgc acaagagagg atttgagagg cctgtggagt ttctgtctgg 117540 gctgattggt gggggttttc tcctgtaaaa gactagttca tgaagaccag gaaaggtggt 117600 tttttttact aatatgcatg taacaatata gagacttaag ggaaatgaag aaacaggtaa 117660 attatggccc aaaggaacag atacatctcc aaaaactaac actaataaag agatatataa 117720 tttacctaaa ttatatataa ataaaatagc atctttatgg cagataaatt aaaatatctt 117780 ccataaagat gctcaacaag gtcaacagga taccaaggtc agcataaata aactgaggat 117840 tttaacagaa attctatgaa aatttaccaa acagaatttt ggatctgaag aatgcaataa 117900 ctgaattgaa acattcacta gaagatttca gcagcagact agattaggtt aaaaaaaaag 117960 tcagcaaatt tgaagacaga tcattggaaa ttactcagag aagcaaaaaa aaaaaaaaaa 118020 aagaaaaaaa gaatgaatga aaaggattga agaaaacatg atgatgagtt tatgggacac 118080 aatcaatggg ccaatataca cacatattat gtgagttcca gaacaagata agcgaaagaa 118140 agggccaaaa acttattcaa aaaaataata actgaaaact tcccacatct ggtgaaggaa 118200 atagatattc acatctagga agttcaacag atcacaagta agatgaaccc aactggtcta 118260 cactgagaca tgttattatc aaactgtaaa aaggcagatg aaaaattctg aaaactccaa 118320 gagaaaaatg acttgtcaca tattaagaca tcctcataag gctattagtg gatttctcaa 118380 caaaagttgc ttctctttaa aaaaaagtct actattttct gattatcttc ttctgccttc 118440 tgttatagta catcaatttt attttcttat tcagtaaatt attatttgga ttttttcatc 118500 ttgtactttt ctgatctact ttaatatgca tttcacatta cattgtttat ttctctagtt 118560 attcttgaat atttttaatg acttcttctt cttacttcat cactatatct accttaaact 118620 atctgagtac acttactatg ctatttttaa tgttttgaac tttcttttct aataattttg 118680 gttcgtttag taaaaagtgt ctatatgttt ctttcatccc gtgtgcttat gttcccttag 118740 tggtattgac tattacacta gtaatacgta ctagtgaaat gttgaatgct gacccctaga 118800 gtcatcataa agaagtatgt catgattaga atttatatat ggcaaaaaca aaagtgttca 118860 atattactat ttttctgtaa agattttaac ataatcacct tctactgttt cttttatttt 118920 aattatgtat aattactttg taggacttaa agttattccg ccatcatttt tccttcattg 118980 aaacattaaa catagctctg attttctttt ttaaataaag ataatcagat acttatttga 119040 aattcttaat tattttttat aatacctgaa attttttaat ttccgtaaat gagacctcag 119100 gccttcaaaa tgtctttgaa tttggtgtaa aaaatttact tagagcactt gagatacaaa 119160 ataatgaaag catactaatt acatgttatt gtatttggcc agtaagaaag aatggctaag 119220 gcaaccaaat ggttaatcca agcataacca tgcatgtatt acacaatttt tctcaccttc 119280 cgtattgaac gttgacatca agtaatataa gactgctgat cagaggaagt gacctgaggg 119340 acaaaataga ctgcaatgtg actggaagaa gaatcttagt gtctgcatct tttagtatct 119400 ttcacttatg tagatattgg ggtaaaaata aaaatttgtg tcttcttttc tgatttcaga 119460 tgtctttcca catatgtagt ggcattctgc taccagcatg gctgacccac aatagctgat 119520 ttttaaatct ttaggaattt tgtaatgaag ttgttaaaaa tcatttaaaa ctattattaa 119580 aattaaagtc attttaaaat gccagccaat attaaaaatt aacttctata tacttacaaa 119640 tattagttta ctgaatttta ctatcatcta tgctcttgag gttatttgca actattttct 119700 gaatggtaga aatgccacac aatgatgtgc tgctgtgcat ctcttctcag tttcacattc 119760 tgcagcatca gaagctggta gcttgaaatg agtcgtagcg ttagtatcta tacctcagaa 119820 atctgcaagc accgcacctc aggatttgat ttattgtttt gtagataatc taaatttaag 119880 aaaatgatag agaaaatgct aataaggcaa attacaaata aaagtgtgta gagcctgtag 119940 tggttatgtt gtgattagca caaaaaatga ggaaatattc ttctagtatt cacaaactat 120000 tatctaactc aacaaaggag tcactcatgt cgaagacaaa caagtgaggt ttctacacct 120060 accacaattg cttcactttc atcttattca ttatcataag tgaaaatatc aaccaacaat 120120 caggtcagaa ctacactaat tcatgaattg caaccatttt ggctatagat accaggttca 120180 gcaaaattca actgaagaat tatgtgagaa ttaatggact atatgaaact tacaacagag 120240 tattgtatat attgttatta tttttaaatt gtgtgttata caacctttat atcagtaaaa 120300 gtcatagtaa acctgcatat gtataaatgg atatacatat gtagattttt taaaaataga 120360 gctggttttt aaacacctgt gagcacgcca ctaccactgt gcacatggat taagtctcag 120420 ataactccaa atatccattt aacttctcac atcatggttc atcctttggt tcattgtctc 120480 tctccctttt tctctctctc cctctctctc tctttttttt tttttttttt taatcacaca 120540 tcactagatg gtgaaggaca tgagagtacc caggaaggaa ggcttataaa gaatttgtga 120600 ttttagttga tctcttacac ttgacagaga aagaaatctg cacctcaaat cttcttcact 120660 agggctgtat gaagactagc atttcagcaa acagttgctg tagagatgca aatccagttg 120720 gattcagcat gaagtgtgca agtaaaaata cttgattcgt ggacttcctg ataagaccta 120780 tctcaaggca gcaataaagg ctatgtatga ccattgtctc aatacttgca aaaataacag 120840 aaactcagat tgagattgga gacttttctt ggccatagct aacagctcct agtattttaa 120900 atatgattaa acataaccac aaatgaagag tgtattatta aataaggttg caggaaacta 120960 tttaaacaaa gactcttaac atggggggta agtctgcatg gcaaattcat gtagaccttt 121020 tctgtcttag gagaggttat tttgtttatt tgtttgtttg ttttttcttc agtctgagga 121080 tgttgattga aaattgctaa caatttgaaa tagcgagtag gttgaagtca tgtttttgta 121140 tttagtaacc agcccacata ttcctattta aaaacaaggt tgcaaaaatt agggttttca 121200 ctccatctgt ttaaaactgg ttttcctagt ctgggagttc ttttttaata tcataaaata 121260 aaatatttct cactaaaaca tgacaaaaac tttattacta agaaatcaga gctattctgt 121320 ggagatttgg aaagaaaaaa taatccagtt cactttagaa caaatcctct catagttacc 121380 cattgttagt attttgacat ttctaccttt tagaatacaa gttaggattt attacatgtc 121440 attcagcaag aataaacaaa tgaaaaaacc ctgcagctaa taaattcagc atacctgtaa 121500 tgaaaataaa tgctggtatt ccatgttttt tgcagattta ctagattttc cttaaaagaa 121560 tggattaagt atagatattc actgtataca atattttaca ataaggttct ttgaaatagc 121620 aagctcccac taatgagctg aataaaagaa tagctaggat ggaaggaatt gtagtgagta 121680 ggcctacata cacattgtca ctaccaggaa ctaaggctct gttatcttgt ctgaaacata 121740 cagctagtat atatacatac atacccaatg gggacaagag cttgtgtcac ctaacttccc 121800 ttctttcaga aagaataaaa ttatcagtgg attggaagag aggtgggaga ttttgtttcc 121860 aaattctttt ctgcatctga aaatttttaa ctctgactct taaaattgga tagccataca 121920 acatgtcaga aacatatcca ccgggcaaaa taaagtttac tcacttaccg agtgaacatg 121980 actttataga gagcaactaa aaaggtatcc atatgcagaa tcagagacat ttgaaattaa 122040 aggatatgtg gagactagag aagaaatgtt ttattctaaa ctctgtatgt taactataaa 122100 catggattga tactttttaa acataaaata tatcataata taaatatcaa aatgagtgtt 122160 gttccattca atagcatggc tcttgttata ctatgacact cacaacccaa ttttgaaagt 122220 tcttccagag ccactttatg agccatcagt gaaaaggaga gtctcattat gtttcagtcc 122280 caacacattt ttgatgaaga atgtataagc tctgctttgt tcataccacg ttctctacag 122340 tgggctttaa atgatttcag gctatttcct aaaccaagtc tactctcaaa gagataaaac 122400 acattcactg ttaaatgtat taatgttatg ttaaattttc acaagctctt aagataatta 122460 taaaaagttg caagaaacat gtttagacaa tgatggtcat tgaagtcagt gcaccacctg 122520 ccagtaggtt gattttgaga tgaaaacact acttggaagt tacagcctga tatgttaaaa 122580 aatgtatatg gccataccac cctgaacgca tccaatctca tctgatatgt taaaaaaaat 122640 catgtcacat tttaggtgca gatttctttc tctgtcaagt gttaagagat caactaaaat 122700 cacaaattct ttataagcct tccttcctgg gtactctcct gtccttcacc atctagtgat 122760 gtgtgattaa agaaaaaaaa aagagagaga gagggagaga gagaaaaagg gagagagaca 122820 atgaaccaaa ggatgaacca tgatgtgaga agttaaatgg atgtttggag ttaatcatgt 122880 cagttaaatg tggcatgaga ttttaaaata aaatataggt gtccagagtt tttagggctt 122940 cttctagatg tcagctaagg aattttattc tttagggact gtttataatt gtacttttca 123000 agtaatactg aattcatttc aataatcagc ctttatctca ttcattcatt cattcactca 123060 agtgtcagga atacagctgt agaaaaacag gcgcttattc tccagtgaaa gaaactgaaa 123120 ataaatacgt ggtgactaat ataaagtcag ggtaagaaga gctatgggga aaaattaagc 123180 aaaagaagga tgtgttaagg aacgccaact taatcaagaa agtcctcttt gagaagctga 123240 caaatgagca taaatctaag tgcagatagt ggaaatgtgt tcctaccaga aggaacaatt 123300 gcatagattc tgaggacttt gaagaatgac aaggtgcaaa ttgaggctga agagcagtga 123360 gcaggaggct ggtgataaga gagatggacc tttccttagc atggagtttg gaaagtaatg 123420 aagggcacag tacctggagt cagatcattt ggatctacat gctagcttta ttgaatatta 123480 tctgtataca atttacctaa cctctccatg ttttggatcc ccacctgcca aatggggaaa 123540 gcagtagtaa cgtctcatag atgtgccaat taaataacat gcatggcact ttacatgttg 123600 cataaaagat gacatattag gtgaagaaag agtagagaca tgaagtagta tcttttttaa 123660 aaaagaacat tgtctgttca catattaaaa tgggaaacct tataaagatt taacctttta 123720 gttctacctt gtaattaggg cttcccatgc agttatttct ttcaaccctc tctgcaacag 123780 ctgccattta tttacattta ggtttagctg cctttcttta aagcaacact ctttctaccc 123840 aagatcataa taaaaaaggc aacgtttaat gattttttct ataatcacag aagtattaaa 123900 tgttccctaa agacattttt aacaaccaga attataaata taagaaaata atatacatca 123960 tggctgtaat cacagaatac cttccaagat cattacatat tggtgaattg aactatttcc 124020 agtgatttaa tattgtggta aatgtttgat catattttat ggccacagtt tgaatcatat 124080 tggtctgctc caaaacttgt gctccttctt cacataaact tatagcataa aataccctgg 124140 gtataagaat gccaaagagc ttttgaaaag ggcttaatag tcaatgatat cttcacttat 124200 tgagaaagcc ctaataaata ataatataaa acactttact gtagcatgta agtacaatac 124260 tatattagct ggataaagtt ttattacaag atcgtgctaa tgtaaagcac tcagcaatct 124320 aggaaacaga gatgaaagaa cacatataat ctatcttctg tttaacagac aagaatcctg 124380 agactcagag aaaatgctat ctgtttaaaa gtcacagaag acaaaacagt aaatttttaa 124440 aataccaaac ctaattcagt gcctttttag tttttgagaa caaattttta tagaataaat 124500 aacaatcacg tgactagact tcaaaaaaac ttagaacatt aatttttagg tggggttttc 124560 tttgtgtgct gatctgcagc catgaactac gagagccttg tttcactaaa ggctatgacc 124620 aatcagaact ttgagaagat ttcttttgat agtaagtaag ataatatcat agaaaaggac 124680 ttgaagtatg gaaatccact attttaaacc tattttatat agatagacat tctattttga 124740 aacttttaga ataagaagca cagcaatgaa ggaaaagtaa ggaataataa aatttttaat 124800 ttgttttaaa aattactaag atttgttaaa ggaccttccg aagtgtggtg tgcacacaca 124860 cacacacaca cacacacaca cacaaagaca tgctcccaga tggaaagatc tatactgtaa 124920 acatatcaga acaacccaaa ttaatctata catttaacat aattttaatc aaaattaatt 124980 ctaaacatac ttcccatact ttccacttat ttttaagtaa agttttaatt ttgagataat 125040 tgtagcttta tgtgcagctt taagaaatca gacagagaca tatatgtacc ctttatctaa 125100 ttccccccat gggaacaact tgcaaaactg tagtacaata tcacaaccag gattttgaca 125160 atcattttcc aagacactgc ttctgtcaca attgctgacg taccattggc ccagcaaata 125220 acatggctca atttagaata tggggcaaga taatttactc caacatcttg ttcaaagaag 125280 ctacaaagtc ctggtgaagg gcatagctac agggagagct gatgatctgg ggacattatg 125340 ggatcagtcc accataccaa ctgatatagt ttggatattt gtccccaccc aaatctcatg 125400 atgaattgta ttatctgatg ctggagatgg gtcctggtgg gagatgtttg aatcatgggg 125460 gtgggtcgct tatagattgg tactgtcttc gtgacagtga gctctctcaa gatctggtca 125520 tttaaaagtg tgtggcactt acccacttct ttgctcctgc ttttgccatg tgaaatgcct 125580 attcccactt cactttctgc catgattgta agctccctga ggcttcccca gaaacagatg 125640 cttcctgtac agcttgcaga accatcagcc aattaagcct cttttttaaa ataaattacc 125700 cattctcagg tatttcttta tagtaatcca caatggccta atataccaac ttatgacatt 125760 gctgtaagga tgaaatagtg tacttcaaag cccttcgtat aatacatttt acacattttg 125820 ttactctcat attagcatga tattctcatt attagcatga catttataac aaagctgttt 125880 ttactaacct atagctttag gacagaggtc agcaaagttt ggcccctggg ctacacctgg 125940 cccactatct ctttttatat agcccgtaag aataggttta catttttaaa cgattgaaaa 126000 aagaattaaa atttaaggat aatattttgt ttcatgtgga aattatataa aatctaaatt 126060 tcagtgtcca taaagtttca ccggaacaca gccatcctca gtttacatat tgtctagact 126120 gcttttccac accaatggca gaactgagta gttgcaagaa gagctatgtg gactgcattg 126180 cctaaaatat ttactatctg gtcctttaca gagaaagttt gccaaccccc tgtttcagaa 126240 tatttatgtg gagctcctta ggttttaaac agacattttt aaagaagtct agcctggtta 126300 ttgagtcact tctctaagat ccttcagtga atatttggaa gggttaggac tgctattaca 126360 tgtgactttg actagaaata ttgttaatgt acctgctttg tcagcttaat acatacctta 126420 ttttcctccc tcacggctct tttgttttaa tatttcaact tcacactagc tggctatccc 126480 tgtactcctt gcagcccagg tttggaacat taactgatat gagtcttagt ggctagttgt 126540 tgcctgcaaa attttcctaa agaaaaagtc cactcctgga agcacgtgtc aattctcctt 126600 cctgtcagag gcaacaaaaa ctattaatat aacccccagg ctggagtcta ttggctctga 126660 cctaactatt taggttcaag ctagacataa tcctgcagta aatagtggat aataactagt 126720 aaaaggaata ggctggcacg gaactcagat attccaacta caactgttag aataatacta 126780 cattggctag gcacggtggc tcatgcctgt aatcccagca ctttgggagg ccgaggcggt 126840 ggatcacctg atttcaggag tttgagacca gcctggccaa catggtaaaa ccccatctct 126900 tctaaaaata gaaaaattag ctggacatgg tggcaggcgc ctgtaatccc agctacccgg 126960 gaggctgagg caggagaatc acttgaaccc gggaggcaga ggttgcagtg agctgagatc 127020 atgctattgt attccagcct gggtgacaag ggcaaaactc tgtttgaaaa aacaaaacaa 127080 acaaacaaaa aagaaaaaca acaacaataa tactacatta ctctatatgt gtggttcata 127140 agatgtttag ctcacatttt caaatcatct ttatttttta aattaaataa ttttttatcg 127200 aaataaacat gtcagaatta aaaatctacc ctcaagcata ccattatgct tatatatact 127260 acctttcagt tttgaactac tttcagttat caatatattt aattttatgg ctagtaacta 127320 aactagcctg agcaatttta tgtaattctt cataatcaag tgtaaacata agcctcattt 127380 tttatctttc ttaatgctaa aataaatttc taggtattca gtacagtttg ggatcaaaat 127440 actattaatt ttggccatag gtacaagcca cgagacatgt cctctgtcca tcagatattt 127500 tgtggctcaa acagcagttt tcttaacact tctttgtctc agaatttgcc ttcccagttg 127560 agatgctctc tctttctgtc tcaactggtg aaataaagaa tctacatccc tgttgtctct 127620 tgcagtaaat acgtcgtcta tgtctgcttt ttccaatcat aagaaattgt caggagcctg 127680 agaccagcct ggccaacaga ccagcctggg gaagccccgt ctctactaaa aatgcaaaaa 127740 ttagctgggt gtggtggtgg gtgcctgtaa tctcagctac ttgggagcct gaggcaggag 127800 aatcatttaa acccagggat tcatcctgaa tcagttattt gaactctgta cacatctttc 127860 cctctacatg actaaaaacg agagtgatta cagccaggta gctacaactt ccaaaacagc 127920 atccaattgg cattttacaa tcaaatgtaa acactttttc cctttacttt aaatgaagta 127980 agaagaactt ttcttctgcc tagcaaagct cagtgaactg ctctgacaag tggcttggaa 128040 agtgaaagct gaaattggct tctatgcttt ttaaatggtc atctaaatga tacgtgttga 128100 aaactgacag caagtaagtt gctaaaataa cagtattaaa gtattcatat actaaaaagg 128160 acactataga tattttagaa agtgtacatt aacctatttc aagaacattt tgagaccgaa 128220 ttgttcattt aatctgtcat cttcctttgt tttaaaatca ctctgagagc tgtctgtttc 128280 aaactctcat tattttaagc cattctgagt ttagacgaat aactgtatct gaaccattct 128340 cccctcttat gcagcagaaa gtcagctatt tattcatgaa aaactagaag agaaagtgga 128400 aggggtttca gagtaggact cttggagagc actctgccag tgccagagaa caactttatt 128460 gagttaggta gagatggact ttggagctgg tgataaagta aaacaggaga cattttcaca 128520 aagagaacca acaggtgtgc tcagaactgc agagaaaaaa aaaacgtgca tcacaggggc 128580 aattttctgt gattctcaaa aatctgcttt tgttcagctg acattaaact tcttcacttt 128640 gtttttcaat tctaaagatg ccaagaattc actggctaaa aatatgagag gaaaaaccat 128700 gctacatttc aaaatttagt cactttaagt gccgtgtaaa gagtcttgta cttgagggca 128760 aagcacactt tgatcaaagc acttgggtcc tgttgtgaag ctttgaagag aaaatgcaac 128820 atcctaagcg cataacaatg aaaaagggaa aaagacagat gggaagagaa gaccaagaaa 128880 ctgctctcct tttgtcattt tctccctctt tatcctttca tatctattgc ccttagcatt 128940 ttttttgttt gttttgtctg tttgggcccc ttcccttttc ctttttttcc ctgcccttct 129000 gaaggtaata gctattataa acctgcttca ctgtaggaac tgaggcttct gctgcattct 129060 cctcttttta gaggaacaag aaaacgttta ctgtgtgaag cattcagaac ttactctggt 129120 tgtcaacttc taagttgaga gcatatttta ccctttccaa cttttgagtt atgttaactg 129180 ctaaagagta acatgacttg tgggcattag gaaaacgtcc tccaaggttg aacgggcaca 129240 caatagctca aagttattct tataatgaaa aaaataagaa ctaaatttcc tttgaaatct 129300 attactgaaa atgcaggatg aagatggagg tggggtacta cttgcgattt ttgttgagca 129360 acgcacgttg cagaagtctt tcaaatgtat aacctgtttc ccaaaggacc agccatttct 129420 cccatttata ttttatcaag gtgttgctgg tcagagactg ttttcaagtg ccttcctggc 129480 aaagccagag actaatagat taatggtggt aatagcagcc tcagtgaaag agttctaaaa 129540 atacagtacc tttcaaaatc tctgctgata caaaggccgg atgataacat ctagattatt 129600 gctctaggaa tattttcagc ccagagggca tgcactgaat aaaacagggg caagactatt 129660 atgtaatcta catttcccct taataactct ggcccctggc cttgtggttt tcacatatcg 129720 tttcaaagac tttcctatta tttttagaca aatatttttt cagacacatg gaaatgtatt 129780 atagaaagta taatggtaat tttaaacatc ttataggtta agtttttttt tctgtggttg 129840 tggagttgaa gtgacattga agaggatcat gatatgaatc caaagcaaaa ttgcaaaatg 129900 gcggtttgta ggccataaca catctgttct gcttgaactg taatatatta gaagaatttg 129960 agtcaacttt taaaatctat aaatttccca ttaaaaagtc agggtgccca gcttctcctg 130020 aaaacttgga agatctggtt gcactaagtc tatattcaga aacagcaaaa atcaaccaaa 130080 gctaagtagc agcagctgct agcaggcagc tctggccaat gttccctgga atccttgata 130140 cttattgcat ccttacgcag tccttgtgtt atatacctac tgtcctccca ctgcattcat 130200 gcatacaact ttccccgaag gcttttgagt ctgtgatcct cattccaacc aaacactaaa 130260 attagaatgt gtcttctcct aaatattaat agacaatagt gctaacttgc ttgcactttc 130320 tgagtgtgtg tgtaaacaca ggtttctgat gactcattgt gcaattctgc tgcacagtgt 130380 actcagcttc tccgcagggc cagtgccaaa ggacaaacaa taaataggct tgggtcatta 130440 gcagatcaat ggaaacaaaa atagaagttc taaaaaaaat tctaaaaata agcttatcta 130500 attttattat acatgcatgt tttgtagttt acagcttagc attgttttgt ttcaaattgt 130560 tatggcattc cccacattca ttttagtgct tcagggtcta taaaagattt gtctggctaa 130620 ttctgagcaa ctggctttca aagcccctct tgagtcttgg agataatttt gggtgtcaga 130680 tttatttcat acgatatgga gcaaagctat tttaacatct gaccatctct gctcacatta 130740 ttggcaagtc tttggctgtc accctggaaa actaatttac ttccacttgt tcttttcttt 130800 tttcttatct gtcttgtttg atgctcattc atgtgcagaa gggtgggttc ccttcaatat 130860 ctactctcat cctttcaaca tctactgtta aactaccaag ctgtatatct tcataatttc 130920 agtgacaata tacaatttta aggacatggt acatactggg cagtctgcaa gggtacagat 130980 tataagtttg acaaatattc agggaggaaa ggtatttcta aaggttaatg aagataaaga 131040 gttcttaggg agggcttgag tagagcattt gcagaggcaa tgatggctaa caagtcagga 131100 gaaaggaatt ctgaacacag taagaaaaac aaaggcttaa agatagagtt tgccttgggt 131160 tattgggaaa agtataaaca gatctgtttg gttggagtaa aattttacaa aagaagagag 131220 ggacagaatg tagtggacct tgaattccaa gtttagaagt tcaaagttta ttctacatag 131280 ataagaaata gctacagaag actcagacca ccatcttatg tgagcaatta agaacttctg 131340 ccttatgaaa ccactgttat agatgatcac ccatcttatt tttcagttat tttaggggaa 131400 ggaaaactgt taatgcccac tggattgaga agtttggttt ccagggtttt gctcaatcat 131460 caaaaataag gaatgagctt ctggatctag agattctcag cacttcactg tcacattatt 131520 gttctatact ttcttaagct aatacttgta tcatgcctac tctgagctaa acagttttaa 131580 atactttgtc ttaaatttca gtttttaatc actcttgaaa tatctttttt ctccaggact 131640 aaaatgaact ttatttaatt atcacgataa acctaggaga taggtactaa taccgtctct 131700 attttgcaga tgataaaatt aaagcatatt tggaaactta gggcatagta gggttacaac 131760 aactttttaa tgatgagctt cagcatgcta ctgccccact tctctccatc ataaagtcta 131820 accttgattc tttcatttgt ataattcctt aaatagtagc actaacaaga taagagcaat 131880 catctattga gtgcctacct tgtacttctc tactatgtgt tggtaccagt attaggtgat 131940 tccaaagata tattcaattt ttctacatca tagctgtgtc atctggtatt ctgcaactct 132000 gattttcccc gtctctatga catccacagt gttctttctc tagtctttct ccaggatgac 132060 agggtgtgta tgtaatgttg attcctttac agatgcacat tatatatttg tcatcaaatt 132120 ctcactactt gtaaccattc tacttatctc tagtggttct ctttggcact ctattgaaca 132180 atgattccaa tctttaatcc tcccagaagc cctcgtttca cccctaaatc ctttcactta 132240 gaaaatggcc ttagagaaga tgagcttcct gagcttcact cttctcacag taaaaaattc 132300 tcacctatct ctctccctcc tttgatcctg tattaaaaga tgaggtgttc ccctagagag 132360 gaaactaatt gctctactta tacctctagg cctgtgtccc tcaatacttt cgggactttg 132420 atcttcaatg ctttcatttt taaaaattct tttttctttc tctagtccct acctcatatt 132480 ccctggccta caaataaacc caccttagct ttactaaacc aagactttct ctgggcccta 132540 acaataatct agctgctgtc tcaagtcttt cattcctttg tcttaaggac tcccatcctg 132600 accttgtcaa tattttgtat gtttatttga caatatattg ttgagggcct actatatgct 132660 aagaactatt ccatggcctg gaaaattcac agtaaacaaa ataaaattct ttgtcactat 132720 gggtattaca ttgtagaagg gagataaatt tattaaataa ataagaacat attttactgt 132780 ggaaattaag agagccacca agaaaaatag ggtaggcaag agaaatggga agtagatggg 132840 gaggttataa ttttaagaag atcagagagg gaggaatcac tgagaaggaa atatttgaat 132900 aaagtttaga tgaaaatgag gaagcagact tcatggatat ctgggaagaa aagaaagcaa 132960 gtgcagaggc actgggactg aagagtatct gcttattcta gaaaccacca ggaggtcagt 133020 ctggccagaa ctgatcaaat ggggtaaacg tagtagtagg tgatgtcaga tgtgtccagt 133080 gatgtctctt tttcacttct actgtatcct tccctacctt gcattttttg aggatattaa 133140 tacttcttta tatcagagct atttatatac atttcctaca tccttatttg aatttcatct 133200 tccttacagt agtattaatc ttccttacag tagtatttat tcactcacag acaccacctt 133260 tgttcttttg atacaataga tgtgcttgat caatatttct ttaacataat taaattatac 133320 aaatgatgac attaaaaatg aagcatttct ttcaaagcat atttaaaatt attttagtta 133380 atttttttca gatacagctg agtgctagct acatagttta tgacagaaac tatctagttc 133440 gtatcctcca gttgtaaata gaatgatatc tattagtcaa tttggccatt accaactgat 133500 atcaatgctt tctatcttaa aggttaatga tcctagttct ttttaccttt tattaaaatt 133560 tatgaattct gtttgctctt tcaaatctaa agaagtgtca gatattcctg aattaacctc 133620 aaatttatag ctaagatttt tttaaaaaac taaacaaaaa tggaatcaat tagatgcttt 133680 atagttacac caatttgtgt tgtctttctt tactttccaa atccacagag aataaatgat 133740 gttctttgaa tgtaaaatct cttgaggcaa aaaaatggac tgtcacaaga tgtgttaata 133800 agttgtgttc ttgggcttga gtgaatgcat attctagtgt gctgttaaag aacaccatga 133860 aaccggagat agcccttggc tttcagaaat agaaagctcc ccgctccaat tgtactcatt 133920 aaagttctca gttacacacg ttgtaataaa taaagtattg gtttaaatga ccagaccaac 133980 ctctaactgt agttattgcc tttttaagta tgagaggcaa ttttaacatt attattttct 134040 atgtggacaa gcattatgcc aagcctcttc cctcctacag gcagctgcat ttcagaggtg 134100 gtgccatgac tgccctgtgg gtgaaggcaa ttagaggcaa acaatttatc aagagctctg 134160 taagcttctg aaataaaaaa catgttacag aagcaccagt tagtattttt tggtggagtt 134220 tgaacatctt tgattatgtc aaatggtagg gtattaagag taaaaacatt gttttactct 134280 tatctgagct cctgactggg ctctgccatt tgctaactat gaccttgtgg ggttacctaa 134340 tgactgtgac catcagtctt ctcatctgta aaatagggaa aataagggcc ctcttataga 134400 gttgttatga gattgtaata aagcacataa agtacatagt gggaagtata tggaaactgt 134460 tcaaatcatc attatcaata acaacaccac catcattcat atcataagca tgatcattga 134520 cttactaaag tcatttttat ggagattata gattttctcc agttttttac tattggaaaa 134580 attatcagtt tcttaaggtt tctgtaggtt aaaaggggga actttaagta agtctccaag 134640 gtttactagg ttggctaaga catccaaact gcaacgaagc accacggtct ccagcacagc 134700 tcccttagtc ctcctgtctt tgtgtaatgg agcacaaaag attgtacatt tagcagagca 134760 ctctgctgtg acttgaaagt gtacctctgt gggcatgcac agcagaagct catctgaaac 134820 atcaggaact ttgaaatgtg aagtctgact tttaaatcaa gtacatttgt gtagaatgtg 134880 ttttctttct gatattctaa ttttattgaa tcatgaatac tccggctggg agcatgagct 134940 gacagttgat ttagggtgtt ttcacttaat ttttaagtca tttttttggt cttttccaaa 135000 ttggttccca aaattcattg atgagaaaaa tattttgctg acttcattac caagtaccaa 135060 ctttctgctg gatcctctca gcaaggattt agatgggtaa aggctatctg aaactacatg 135120 aaatctgaca ctgcttgagt tgggtcttgc cagtcattca taacatagaa tagtccattt 135180 tatcagctca aagataataa taagtatcat tattggacaa atccatgaag accagcttaa 135240 cacatttgca taatttatac tgtaatgaat ttacatcaga ggagacacaa aatacctata 135300 tgtagacata actaacaaat gagaaataag gcaaatgact tgaatctacc tcacaatttc 135360 agtgccttta aaagacaaat gttatataat gttatagtct tttcataaac tcaggattta 135420 gaaattgtat ctgagtagga ccctagcaat aataaaattg ccattacacc ttacagttgc 135480 acaaggttgc tactttttaa atactttaaa atataccatt ccatacctgc tttcacgtga 135540 acagatagta tctctagttt ctagattaag aaataaaact aaagaatgtt cttatggttc 135600 caataaaacc ccatgacaga atatgcaatg tggtctacag gtaaattcta tacattatat 135660 atcattttta actatcagat taatttgatg taagtttcca agttgttatg aaatatattg 135720 catccgtttt tcttttatag tatgacaatg atttccacat agctgaagtt tgtaaaaaat 135780 gtaagataat agacatgaat tatgatttac aaaaatgtgc ccaattcata atgacaacga 135840 tcactaaaag tgctaaaaaa cttaattcat ttcttttaag ttttacccat cttaatttta 135900 tcaaagcaca gattttcaaa aatatgagac tcttgaaatt cccctgaatt tcttcttcct 135960 tatctcaaac tacttccgat taagaaggca gggaaaaaac attcatgtag gtttctgatg 136020 tctttgcata cactgcctga ccatatagcc attttgcctt caatcactag atatgccaag 136080 tggaggtcat ggttttggag acagatggct aacaatcagg ctcaaagcag cagggaacct 136140 ggaaaaggag atggaaagaa attggctttc ccattgccca gtagggttct ttttgtattg 136200 tatcttctga agctggaaag agaaattcta gctggataaa gctgtggatt tttgaaccac 136260 atatttaaaa ataatagctc ttcaaaaaga caaaagtttc tgaattttag cacttagttt 136320 caccttgaac caaagcataa aactcataaa acagatgctg taatttctat acaatcaaat 136380 gttgtgtttc aagtcagttt aaactcatgg gaagaaaaaa taatgttcat aatgtctttt 136440 cctaagattt caataattga attgcttctc taattgactt tgttgttgtt gttgttgaac 136500 atattaaagt aagaataatg atttgccatt attttgcacc ttttaatttt ttaatctatc 136560 aacattggcc cactctggaa caggtacatt tctctggggg aactaaaaca taggaaatat 136620 tatgtgattt actcaaggtc aaatataatt tcagtggctg gggaggcata acagaatatc 136680 taaaacatat ttctactctg ggaaatatta cccaatctca tatgaaaagt tcacatatag 136740 ttatttgcta atattatagt tttcactgta accctttaaa atgtgtagca gaaatcacag 136800 tattactata aacaaacctc ttgtaccttt attttttatg ttagtaaaaa aaagttttat 136860 attgttcttc tgtctgctct tttccaagaa actcaaatat aatttttgaa cagttggcag 136920 gtggattgct tgatcaaagc atcttctgtt tctgccattt tgttgagatc atatattgtg 136980 tctcagaagt gctagaagat ctagctgtat tgtcagtatt tcagatggct tctgttattc 137040 tcctagtact gtgatgacta tggtataggg gatgcccgtc tagaaaaagt caatgttagt 137100 tctcagttga attgtgaagt agttaaattt taagttttat gcttctgtat tttttaatca 137160 gttttaaaat tccttccccc tttaaagaga ttagctatca agtagacatc ttatacaatg 137220 tttaacattc tccgtgttta agcacatgtg tcatttgaaa ttggtttctt actgtaatgc 137280 aaacatttat gaaataatag acatttcata cattcatcaa accatttctt gttctaacat 137340 tttttatttc tgctggtttt attatctaaa gtatacattc ttaaatcctt gaagtcatgg 137400 actctatccc tttgaggaaa taaaattaaa agttaagagt tgagacatga gtgttattat 137460 accctgttat accattaaac ctagagttga atttgaaccc ggggtctagt ttttatgggt 137520 cattaagtat ttgaccttag atatattgct taagctcact gtaatttagg tgtctcaaat 137580 acaaagtaga gataataatg gtaggccctt catgggtttt ttggggcatc taattaggta 137640 ttgcctattg tgtggcatat ctattattaa ctattatgat ttatctcaaa atactatact 137700 tatttaaata ttaaaactac tcattctttt aaatgtgtat cacattcagc attaaaaata 137760 aatcgtttat tcaaccctgg tgataatcca ggtctttgcg gccttcctga actactgcag 137820 gctctttaca ctctttacac aagcatttat tgtgttctta ccaagatcta gtgcacttgg 137880 ggagccctat atttccaaag ataaatcaaa cactgttcct aaggaaacat tcagcctaat 137940 taggaagaaa gaaaatattc agagatttat aattcctatg accagagagg atgaagaaag 138000 tttacctgga agaggtaaac ttcaagtgag agttgagagg acaaatagaa actcacttga 138060 taaaatcaag agttaggaga aggatcccca agaacaaaga tcagctttta ttaaggacca 138120 gagtgctaag agagaaagga gaattagaga cgcactgctt taaatgtatg aataataatt 138180 taactgtgaa tttgacttct ttttcttaaa atattggaac acatgtctta aattctttcc 138240 tatcacgtct acagtgcact atttgacaga caatatatca tgggataatt gttgcaatta 138300 tttttagata atttttaagc aatttaagta aatgatgagt aataacattt gagacacagt 138360 aattccattg actgtattaa agtgataacg cattatattg aaggtgagaa ccagtagtct 138420 ctaccttatg atatatcttt tatttgacag aacatattga tatcatacaa cttattttac 138480 tactgtggtt tatctgtgca taatatggtg taatagcctc agattttcaa tactgtaaca 138540 gaaaggaggg agctaccaaa tagagatcta gctttgtctg atttctaaag agaatattgt 138600 tcttatcact atcagtaaca atgataatac tatactgaac attttttatc attcttgctg 138660 attattattt ctcattgttc ttgctttact ttaaaaggac cgaatatttt gaaaaaattt 138720 ttttctccat gcatttccct ctagaaaatt gaaattgact gaactatata atgctgatga 138780 gcacctgagc accaacatag aaagtttttt ttcttttttt tttttgagat ggcgtctcac 138840 tctgtcaccc aggctggagt atagtggcgt gatcttggct cactgcaacc tccgcctccc 138900 aagttcatgc aattttcctg cctcaacctc ccaagtagct gggactacag gcatgtacca 138960 ccatgccctg ctaatttttg tatttttagt agagatgggg tttcaccatg ctgaccaggt 139020 tggtctcaaa ctcttgactt tgtgatcagc ccaccttggc ctcccgaagt gctgggatga 139080 caggcgtgag ccactgtgcc cagcccaaca tagaatttgt aatttgctct taaatgttta 139140 taaagttaaa ctctaaccct taagcctcat tttaaactgt ctagtgactg acttttagaa 139200 gtattttaag gtgttaagag attacaattt tgaatacaat gtgttatatg ccccactgct 139260 ccccaaatag ccatttctgt catatctgtt cccttctgtc aacttcatta tttttgtaca 139320 cttggaactg aaaatagtaa gtaaaattat tttcaaagga gagaaatact atataaatgg 139380 atttgaactg agataaattt ttgacagtgt ctgtaagtgt gtaatgaggg cttctaagat 139440 agaaaataga ttatgatttt atatatattt atacatatat acatatattt gctaaatatg 139500 ataattcttc aggtaactcg tcaatgatgc atgattagca aactttttat tatgcatgtt 139560 tcacagtaaa aatatttcac actggataaa ctataaatga aaaataacca cagaaatgag 139620 agtatcttaa ttatttatat ctgacaatat tgaaaatagc tttatttttc ttgttcccag 139680 tgacttcttt ggaatcatta tatttgacag tgtccttagt aacaattcat tgactgtact 139740 ataatagttc tgaaggggcc agggatgcaa tgtgattgtc cttccttata aacagcatct 139800 gattatgtga aaaactgtct gtttcgttag ttatgaaacc agtgccctgg catatagggc 139860 aaacacaaga ataattccat ctctaaagaa caatcccaaa gccttaaaga gagcaaccaa 139920 tatttaacta ttttaataag ccaaaactct gatttttaaa gacaccaaaa cagatttgtt 139980 gtatcatgtt catccagggg aaaagaaatc taaatgaatg agcaacaatc ttccaatttg 140040 tttaaagctt ttgacagact caaaaaagaa acagattctt aaatgttaag gaaaaaactg 140100 agagcaacag tttttaaacc tctgacacaa tcactaagaa acagattctg ttagcttcaa 140160 agaagttgga aatgatcttt atttttcaaa tatgctgaca gtcatgaagt aatggatttt 140220 tttaaaagaa gagaatcctt gcaaacattt acattttttt tcatgtagaa ttcttgattg 140280 gttgtctagt agagcaacga atggcagtct catcatattt aagtcagccc cctttccttt 140340 cccatacgta ccaaaaagat acatttcaaa tcatgatctt tacagggtgg aaactttccc 140400 actgaaagga aagcagagaa gctggcccaa gcggatctct ctgactttcc agtcacgagg 140460 tcagtcagct tgcagcatga acagggattc agaatagcat ctcgtggttc cacagcaaaa 140520 tcataaatgg atgaaaagtg cttgcttttg gtcttttcct acagtggtac tcagaatgtc 140580 tcttctcgtc tcctcccttt gtctggggct ctggggggtt atgtgccccc tcatgcctag 140640 tagcctcaac ttttgacaca tttcttatgt cctgaatgcc tttatttatt aatgaggagc 140700 actcaaagtt ttcctgaaaa ggaaaggaaa tacacgaaga tttgtcaagt ttgtgtttct 140760 ttccattgct tctggaatcg tgctacagag gtcgatgcca acttgaaatt ctggtcatag 140820 tcagaaggta tcgtagctgt ttttaatgaa aaaaaaagta atttttctct tttcttcatt 140880 tcctaggtca cgtttcctag gtgctatttg ctttccttta tttccccatc acttatttat 140940 ttcagaaaac aaagagtgga gggagaggga gggcattatc ttaaagatgt agaacttaat 141000 ggttctttcc atgatgttca aagggtggcc tcccattttc tttagaacat tatgagaaag 141060 aaactgtgtt caccaggaac aggaaaagct gtcctttaag ttattagagg tgattattga 141120 tgatccattt gtcagttagc atttactaag ttaaaagcaa ataaaagaca tgctatcaac 141180 tttcaagctt atcacaaagg taacaaattt gtaaaaatat aaatatttga caagaagctc 141240 aatatgaagt aaagaaccca ttactgcaca ttctgcacat gcaacccaga acttaaagca 141300 taacaacaaa aaagaacaca ttactaagta gtgtaggtta tagagtactg tacacttatc 141360 cagtacattt ctactgtatc ttttggatta aaataaattt attggggaat gaggatgtaa 141420 tgaagtttaa aactgcaagt acacataatg aaatactatt cagccattaa aaaaggaaat 141480 cctgtcacct gtgctaacat agatgaacct ggaggacatt cggtgaaata agacaagcac 141540 agaaagacaa ataccatgtg atctcactta tatgtggtgg ttaccaggga ttgcagttgg 141600 aataattggg gaaatgttgt tcaaaggata cagaatttca gttacataag aggaataagt 141660 tcaagagatc tactgtacaa catggtgact ggagttcata acaatgtatt gtatccttga 141720 aaactgctaa cagaatagat tttaagtttt tcaccacaaa aaatgataag catgtgaggt 141780 aatgcatatg ttaattgtct caatttagcc atttataata tgtatacata tttcaaataa 141840 catatacatg ataaagatat ataattttta tttgtcaatt taataaaact gcaaatatgc 141900 ctgaccaaag aaaatatttt cccacatagt aactatttca gaattaaatc tactctgcca 141960 caaaacataa acttgagaaa ataataacag gtaaatgaga gtaattataa catagggggt 142020 attttaaatg cactaaatat tttaagtgca ttttctcatt tatctccatg gtagtcccat 142080 gatgtttatc ttatggtctc cattttacag atgaagaaat tgaggctcat tgaggagaac 142140 tgaagagata aagtaatttt tcctctaagt aaatgtagaa cctagaaatg aattacaggt 142200 ctgtttgatg tgaagcggtg ctctttctaa tatccaattc tttgagtttt gctcaaacac 142260 agttgattct tagaggtctc taatttgtag ctattataaa aggaatggaa attttatgtg 142320 aaatacaaac ctttttttta aatggcatat taataagcct gaaaaaaact catgcaatgg 142380 aagttaaaaa aaaaaaaata aagacggcga ttaaagttat cctacaaaac aaaaaaaata 142440 tacattcact gacccagaga aaagagtcac aggcagagga atgattaaaa gggaaattta 142500 gtgcttataa gttgtcatgg atttcaatac acaatcatat atgctagggt acataacatt 142560 tctagacaga ggcattaatt taacaggata aaacactttc tcattgatat cggtagtatt 142620 tcattcatat gtataaaatc ttatcttctt gcaaaaatta aatgttttat ggatttgaag 142680 ttaaaaacag gagaatagca gactcaaggt tgaggagaag taattagaga aaagatgaac 142740 tagagtctat gaaatttagt cttcctgtat caactatgtg aatgttgaat ccaatttgta 142800 tgcgctctga aactatgaga gtagtggggc agcattaatt ttaggaatag caaaatctca 142860 cactcaaact attggaagtc caatttggga aattaaatat tcttattgtt ttcagaaatt 142920 gaggcaaata acatgcagtt tttttttctt ttagatagaa aggcagaaat aaggaattaa 142980 aactatagga ggaattaaga tgaggcaacc gaggtaaaca gaagctagtt gtccactcct 143040 taagtcactt tagcaataat ctgattgtta ttattattat tattttggaa tattaataaa 143100 taaagcactg acacagaaaa tcatgcaaaa caaatgttta gcattatgaa ttgttataag 143160 acagacattc ttctatctct acctaggttg agaagcatgg gctatcactt gccccagaag 143220 ccctttccat gccctctgcc agtctcaatc ccttccttcc cttctctttc ctgcccacaa 143280 aataacaatt accctgactt taatattatc aattagaatt tctttttgga gttctcatcc 143340 cattttgtat acttagacac catagtttat ttagccttgc ccattcttta tcaatttaca 143400 atgtgtttaa aattatttca atctacaggt tgaccctcga tcccttattt ttcttatagt 143460 tgattggcac aagtactcag ggcttttgac ctgtagagtt cccagtgtgc attttgctga 143520 ttgcacactt ttggtacaat gcaacatgat tctctgtact ctgtgtttcc tgcaaggtgg 143580 cagatggatt cagactggat caaactcagt tccacccctc tggcaaaatt atgggtggtg 143640 gtgtattctt ttctcaggag ggatataata ttacattacc tctcttttgt gatgttaaca 143700 ttcattggtg ctcaatacct agacctatac atttattggt ggttacaaac ttctagtatt 143760 tattttttat ttattaatgg aaatagtttt ataaagagac cccctccatc agtttataca 143820 gaaatattaa ataaatgaaa ataactaata gaaaatattt gatttctttc catttattta 143880 ccagttttca agataaaatg atttcctgtc atcatccaaa gaccagttag agttttaaag 143940 tataattatg agttcataaa tttaaacata tttggaaggt ttcaatcagt gcaattatta 144000 ttctcattga agctcaaata gtcccgcttt tggcagagga agcattttta ctttggttcc 144060 tgagtgcttt ttcatacgat ttgaccagtt cttgctagct tcttcaataa ctgatatgat 144120 aagattactt agactcattt atgttgacct tgctctaaac ctagaatcaa tctttttttt 144180 tttaagaaga cctaggatct ttttatggaa aaggccacag ttcaagtgca agagatgttc 144240 attgctagtg cagtggtctt tgtctctaga cttcttcaat agacagcatt aggaactaca 144300 tctgtaaaaa taaaatacct catgtatttc tacccaattc atatcaggac tccaggaatt 144360 actatggtca ttattgaagc tcttctttat tttccacagc aaaaaattct agtttcgaag 144420 gactcgggat gatagaatta cagtaacctg aaattattta ttttatacca cattacacaa 144480 gtaatagatg cagaatagca atactactta tcctatttcc aacataatta ctaaaaacat 144540 tcataaaata tttttgcata gtaaatctcc agttctatcc gccatttaca tttttataat 144600 gtagataaat aatactatat ctacattatc taagtacttg gatgtctgat ttctcctttt 144660 actgtcacta agccttagtt ttacaagtaa gcaaagcctt agttttacaa gtaagtttaa 144720 tgatcacctt atcacttatt tctacacctt cgttagtcat ttaacttatc tgaagctcct 144780 tgcctggtag attccttagg aaaagcttat gcaaacaata tttctttatt tgaaagtggt 144840 ctttctgagt ttttaggaat agttagggtt caggatttct tttctaacta catgcagctt 144900 cttttttgtt gttttcttga agtgatccaa aatataaggt ggtttgcttt ccaagatttc 144960 atgtagttgt tcctttaccc cacttttata tggacattct ctctccttca tctctgttgt 145020 caatatccag ttggatttga ctctccttca ataattttcc cctggtgtgg ggtcccggca 145080 tgtcagtttc aagagctaca gggcctaaac cgctgctgcc ccttctgctt tgaagatata 145140 tctggcttgg atctcttgct ccactcacca ttataccagg caaaaccatc cccagattaa 145200 actgctattc tcaagctgac ttttgtgcag ttcagtgaaa acttctagaa cattttggga 145260 ttctcagggt catcagatgc ccagtgactt tcctcagcac agagactcaa atatccatgg 145320 gcctatggct ggcagtggtt tgtcgttata atcttgcatt ttggagttca cagaaatatc 145380 ttgtcaccca gctttgttgc aaatgttgtc tatgggtttt tggttttgct atcctgttaa 145440 tctgcccatc ttgatgttgg gatttgggca aatttgaaaa ctatgtgctg ctgcaaccat 145500 caccaccctc cctaaatcca ataactggtt actattgagt agagacataa aaatattctg 145560 gttaacagca tatagaaaat taatatactt aacatagata acccaaccga tacgtttcca 145620 acttgcttcc ttaggaaaat catgatactt tactccttaa aatatcatta gtatccaaaa 145680 accactgcaa aataagaata gctagattta gtaaaaatct tctccactaa ttgagaaaat 145740 aatgacttta aaaagtacag gtttctaggc ctggtgcagt ggctcacgcc tgcaatccca 145800 gcactttctc acacctgtaa tcacagcagg ttgggaggcc gaggcgggtg gatcactatg 145860 tcaggagttc aagatcagcc tggccaatat ggtgaaaccc catctctact aaaagtacaa 145920 aaattagctg gcatggtggc agatgcctgt ggtcccagct actcgggagg ctgagacagg 145980 agaatcgctt gaacccagaa ggcagaggtt tcagtgaccc gagatcacgc cactgcactc 146040 cagcctggcc aacagagcga gactccgtct aaaaaaaaaa aaaaatacaa gtttgtttta 146100 actctaagct agctggaagt tgtatttcag gcaatcttct ggctgtgagg agtgcttccc 146160 tacctcctct tagtagtttt gccaaaggtt ttcctctatt cctggaagga gcatgaacta 146220 atgagataac ctctgattat gaatcctcac tcccagagaa tgtgacatca gatttctgag 146280 tgaggggctt aaagaatcat aagagcccag attcctcatg tgaggatcac acacacacac 146340 acacacacac acacactctt tcacacatac ccacacgcac cagctggttc tctgagtgtt 146400 taatattgca aagatctatg aatgcccact gcctgtctgc cagagtaaaa tagaactatt 146460 taaagctgag ctgttagggt agaggagaac agtctgagtt cggagttaaa gttttaatga 146520 tctattacag atatctttct caatggcatt ggatgccttt ttttctagta gttgtaaaag 146580 cccaacctcc aaactacaga aggatgttca ttatttccca tgttctgaag catgggtgag 146640 agttctttat aatacttatg ctatgtaaat tactgaatga taagagattt aaaactggtg 146700 gttaattata gttcttcagg aatgttttca gaatgagaat acatatcatt aaaatatgta 146760 gatacttgtt aatagctata tttatactgg tataatacct ttctctaagg gactttgaaa 146820 acactatctc atcaatcttc acaggctttt ttcattaatt tattaaatca ctgtaccatt 146880 taaatttaac aacaatagaa tactgtttct tctatccata atatattaat tgactcttta 146940 ttaatctgta atctcctctg agatagaggc cagtcttcct ttttttctat atttgttaac 147000 atgaggaaag tttcatattt gtgttcacct tacattgaca catttttcag agatttggaa 147060 attatcctca ttcttttcag tcattaagaa atacatacca tcttatttta taaggtttga 147120 ccacatgttc acgagctcct gcctcttggc caactttctt cccaagagaa atattgccag 147180 aacctcctga gacatccagc catcagtggt ttctctcttc cttaactatt ctgatttgca 147240 actggatata tgtgctaacg tcctaactca ttgcacattg aaaataacct ttcactctcc 147300 tgatgctgct tgaacataga ataattcttc cacatcacct tatttatctt taatacttcc 147360 caacttatga cattttctga tatgtgatta gagctggtct gaaaaaaaca caaatgtcat 147420 gctgtagttg aaaaactact aaattaaact tattcaccac acccaccttg aaaatttagc 147480 tcatttcttt ccattataac ctcttatctt ccaggctgtt tctaggtatt acagatgcat 147540 gtgtgctgga tgtgatcatt tttttgtgtg tggtcaattt actcaagaac tgctttgtaa 147600 tgaagaatca gagttaagcc aaagggctca gggatgtgtt tttcaatgag caattttaac 147660 aagtaaaaga cctctaacaa atagtgcatg aagataacta tttagagaat ccctttctcc 147720 caaaacatct tcttttttcc ccatttattc agtatatata tgtggactac tcaacattat 147780 tatctgtgtg gataaaatct aaattttcct ttttacaaat ttaccttttt acaaactaag 147840 caaaataaat gaccatgcag ttttccttta tttactttag ttttttttgt cttgattatt 147900 tagaaggtgt atctggaatc ccagcattaa cttctgtgtc tctcccttta cactctctct 147960 tgctggatta ctcttggtgt gttggctacc ttatgatgct tacttttatt ggatttcatt 148020 tatttcgaag tggcttttaa gatctcccat gtggccccaa attcttgaac actaatattt 148080 gttttatttt ccagtgtttg aaaataaagc acaaatatga acttttctca acccttatca 148140 gctcacctaa agtactgctt ttttcctgca tggtgttgtg ccatcctata ctctaaaata 148200 tcaatagagg aaaaaaatcc aattatctac acttttttct acctactggg ttgtcagtag 148260 aaaaatacgg cagtgaaagt ctgtttctcg ctgtcacaca gacttttcaa atttagtata 148320 ctgtcttttt actgaagtac tcacacactt taactgacat tccagatgca gaagtatgtt 148380 tgtgtgtggt gtgtatgagt gtgcatgtgt gtatatcaag aaattttatt cagagaagtc 148440 tggtatggat tctaagatcc acaattcatt gtactcgtgg tgggtaggag atcatcctgg 148500 tgaacatggt gaaaccccgt ctctactaaa aatacaaaaa gttagccatg tgtggtggcg 148560 tgtgcctatt gtcctagcta cttgggaggc tgaggcacaa gaattgcttg aacccaagag 148620 gtggatgttg cagtgagccg agatcacact actcactgca ctccagactg ggctacagag 148680 ccagactcta gctccaaaaa aaaaaaaaac tcaatgttgt ttgcatcaac attaatttcc 148740 cttacacaat gccaatgtca ttgtcttaat gataaataga tgcaggttat catatttgca 148800 gaactaaaca cagttgatca tatggtacca atagatcagc agcagtagaa atcacaggag 148860 aaaaatgtaa gcttttaatt taagctatca agagacaatt accaaatctt aacctcaggg 148920 acactgatgt ttgatgtctt tctcaaaggt cagaattgtt tcacaatctt tcaattgatt 148980 gatatcatca tttaaaaatt aattagtagt aacagcaata tttgacttta aaatgtgaca 149040 taatctgcca aattatgtgc aagtagtctt ggtttgctat tcagttgtgg ggtgtgttga 149100 ggaaatgtag aatcaaggaa cagtttttag ccttatttca atggaatttt aaattatgcc 149160 tcatatacat gtggaaaata taacctctta gcctgttatt ttcatgagta gagatgatct 149220 agccaatcat aatactcatg aatttataat aacagactga ccacagctat aaaattgtta 149280 ttacaaaaag tatctcttgt ttttcctata attcatcatt ttaaagaatt tgctactata 149340 aaatttttcg taagagaagt gagttagcag aaatcactct taccctacct gctgaacaat 149400 gtctctttga tcagttctca aattgagttt ataggtaaaa attcactcaa acaaaagtct 149460 ccacaggtta caaaaaattt agctattgac ctagagcaat aataaatggc atataaagcc 149520 taaaatataa ataggaatgg agtccatgaa gttaaatcgt aacagtggtc ctagaaaaat 149580 atattcagaa caattcagag gaaaccacca ctctgtcttc tctatgaatt tggcatatca 149640 acatgctttc tattatagtt aaggtgtata gtcatttaat ctcaaatgta atatttagag 149700 ctatacctgt ttggagagat gtctgtttaa tatttagaga gctatctgat tgttgttatt 149760 gttggttaat ttagtagtca gtccctatca ttcatggatg gaaatagccc tactgagtag 149820 agtctgtggc caggaagcag acaaattcct ccctatcttt attaacactg agtaagtgga 149880 acaaaagata attggaactg gcctgatatt tacctaataa gaatgcaggg atctgaccaa 149940 gaaattccag cacatgggat agtgctgaaa attatataag caatacactt cccctgtaga 150000 aataaaaagt aaacttttct gtgcaagttt tctctcccta aataaaggtg ctgttaacat 150060 gccaattatc tgagaacata atgttgacca aattctactg tataaggaca gatattgctt 150120 cccttccttc tctttgtcct tgttgggttg tataaagaaa agtcccagga tgccagcaga 150180 aagcaaagat tcttcagaga gccattgctt gtaaataaga tagtaatgct tctcttactc 150240 atactcctta ccctctttac tctcctcaag tattttttaa tctaaaaggc atattgagat 150300 gtttatatat ttcctctata aaacagaatt tctagaaata atttaattgt atactaaata 150360 gtgcatctgc aatcccagac aaatgaatga tgggtaaaac cagcatttcc tttacttgag 150420 tcaatatggc cctgaaaggc actaaaaact tttttttaac ttttatttta agttcatggg 150480 tacaagtgca ggtttgttac ataggtaaat ttgtgtcatg ggggtttgtt gtacagatta 150540 tttcattacc taggtattaa gcctagtacc cattagttat ttttcctgat tctcttcctc 150600 tttccacttt ccaccctctg aaaggtcagc gtgtgttgtt tccctctatg tgtccaagta 150660 tcctcatcat ttagctccca cttataagtg agaatatgta gtatttggtt ttctgtccct 150720 gtgtcagttt gctaaggata atagcctcca gctccatcta tgtccctgca aagaacatga 150780 tctcattgtt tttttatggt tgcatattat tccatggtgt atatgtacca cattttcttt 150840 atccagtcta tcattggtga gcatttaaat tgattccttg tcttcgctat tgtgaatagt 150900 gctgcaatga acatcatgca tgtgtcatta gtattaataa tagaatgatt tatcttcctt 150960 tgggtatata cccagtaatg ggattgctag attgaatggc acttctgtta tttgggcttc 151020 tctcttatta agtagaacca ctggaatgtt aaaaatatat tttctgctgg gaaagcaaac 151080 ataatgccta gaactaaaac tcaatatcta cgatatgcaa agttcagtta aatctgttta 151140 tattaaacat tgaagaatgt ttaatttgat tattttatta aattaaacat taattaaata 151200 aaatgtttta tattaaaatg tgaggcctaa atacattttc acagaaaaaa ataagcagat 151260 ttaactaaac cttgcatatt gtagttattg agttattgta ggcattgtgt ttgctttttc 151320 agcagaaaac atatttttaa cattcctgtg ctactgaatg agagacatct aaatacccat 151380 aataattaaa tttggctggg caaggtggct catgcctgta atcccagcac tttgggcggc 151440 cgaggcaggt ggatcacctg aggtcaagag tttgaaacca gcctagtcaa catggtgaaa 151500 ccccatctct actaaaaata caaaaaatca gccaggcatg gtggtggatg cctgtaatcc 151560 cagctactca ggaagctgag acaggagaac tgcttgaact tgggagatgt aggttgcagt 151620 gagccgagat cgtgcctttg cactccagcc tgcaacaaga gtgaaactcc atctcaaata 151680 ataataataa taataataat agtaactaaa tgtaatacaa taatgaaata ctgtcttcag 151740 cctttagtat catgggagta taataataga tactatttat tgaagatgta tgatgtgcca 151800 gaaagtgact tgggcaattg gggaacatta ttgcctttct acttagattt acaactctgt 151860 caggtagggg gaaataagtg cctttaacag ataagaaaat tgaggctcaa aagttaccca 151920 gcaaataagc aacagaaaaa ggattcattc cagatcattc tgcctccata tattggcttt 151980 ttgcactgta gcagcttata aaactctggg agacaagacc atacacccac ctgttaaatg 152040 acaattaaac acagcatgtc attaaacagc agtgcagaca gcagagacca aaaaagaaaa 152100 aaaaaaaaaa agaatggggg caggagaggt tattcttaaa gagataacac agaaccagag 152160 aattatatta aaaataccta taccacagtg atttttatgc atacctgatt ctaggagtca 152220 ttcagtggct tgaatcgagg acaaagttca gtgtgaattc caggtgcaac tcgaaagcag 152280 atttcaatgt tatgatttct gattaaacta aaagagacta ctgtgttttc atgtgccagc 152340 cacatgatta caaatctgaa cctttttggg ttccctattt gttgaggcta tggaatctct 152400 gtatgcagtc tttagcgccc aactgggagt gacacaagag aattctaggc atagtgtaca 152460 actacgcagt tatggaaatg tgccagtaga actttatggg tgaaaaactg gaatccatga 152520 atctgtgtcc taaaattaaa tttgacaaaa ggaggtgaac atatgttcag gaataaatat 152580 gacaggagac agtttgtgtt ttttcctgag gtagctatat ctacatgttt caaattctta 152640 acagctaaag gatgagttga accagattac ttaataaatc ataactccat tggaaaactg 152700 taaattgact aaatggagtg tcttaaatag agttagccct gtattcctct catgcaataa 152760 aatagactgg ttaaatctac atgcctccta attgcataat gatttttaat tttattctca 152820 aaactttaat attggtccta catattataa attatcacta gtaaatttgc tttttaattg 152880 ttttaccgtg cagtgaaata tgctttagtt gaacatttct tgattaaatg cctgataaca 152940 ttaacctgca ttgtacatac acatagtttt tatttactag aaaggcttgt gagccatttt 153000 acttagaaac ccatcttttg aatgtacttt tgttagacaa aatcagtcta gtgatgtttg 153060 cacagaaaga aaaagctgat atttaaatta atgtaccctt aatcttgacc catggctcag 153120 ctgtcaaaat agtgggtctt taccagtggt gtgctaataa atatctaaca agcaatgttc 153180 taatgggcag ggggagttgt gatttgtagc atttgccaac tttcgtggtg taaatatttc 153240 caacatagct gatctcaagc taccaaggtg acatcgctga atgtagaatt gggaaaaatt 153300 gcatagtcac aggccatatt tcctgttaaa taattttgac tgtacagatt cataggcata 153360 cataacccaa aggcatatat aataataaaa tgttgtccaa taattagaaa gtaatatttt 153420 tgtatatttg ttaccttttt agaaagtata atctaatttt aaaggtacac aatttaatta 153480 ttaaaaatag ttatgtttag ccactgtcct gcaaaagtcc tgaaaattct ttcttgagag 153540 ccagtgtgaa ctagtctgaa ccactgtaag ccaggtccag caggccattg ttactgagca 153600 cattttctcc atgactacat ggcaatgcaa atcgtcaagg ttgtgaatgt gagggagtga 153660 ggcgtgaaga tggcaccgtg gagaatatga cccgaggctg accaagcaaa atcaatgtca 153720 aggctgaggg tgttaccagc cgtatttttc ctaatgggaa tttttattac tgaggaaaga 153780 tagagggaca ctcgcttttt ggtgtgttgc tgcttatgat gccctttaca aatctagaga 153840 gggaatcctg gggactgtta gcagccacaa ctcctctttg acagaaatac tttcttctaa 153900 aaataaccct gtcccatact gaacatgggc tttactgggg atctggagta ttcagacgaa 153960 cagaaaattg ttcatcttca atgaagcagt tgttgaaact tcatgtgcag cagctcacat 154020 gcctggcaga ctgatgaccc tcaagaactt ttttgacctt ggtaggtttg tctgtgaaac 154080 tggttcaggc ctaaaaggca caggcacatt tataaaagga aagaatatag aagaatatac 154140 acaattacag aaaggattag ggaaacattt cgaaggagac aagtagagat ccacagttct 154200 cttaaggcat gcaactttat tcagatattt agatgaaccc ctgccagact ctctctaaag 154260 gctgaactaa tttgcatatt ttgtagacaa acatttgtaa aacatgatcc acattgtctc 154320 actgggtaac ccttatgacc aaaccatgac aaacatctat accattactt gccaagtttg 154380 gtaatgttat ctctgataat aaatagaata tggtttgcac tggctagtct tggctgataa 154440 aattactttt atttgtttgg gaaattagca aaaactcagg attggaaacg aattggtaca 154500 ttcacttctc tgcttggccg agaagttaac tgctttggat atttgatttg ctttgttttg 154560 tttttaacat ccagctaaaa atgaaagcaa acatgttttt taatttgggc ttttgaattg 154620 ggagattgct gttaatgaat tagagcttaa ctcctcagct ataaaagaga actatatagg 154680 atgacagcaa aatacttagg agaaacgttt tatacccttc agatggtaat gccattgccc 154740 caccatacac taaacttttc ttaatagctg atgaatacac tttcccactt tatttctcaa 154800 tccccttgac ctgggttgac ttattccatt aaaactatct tatggtccgg acagtaatat 154860 tagagaataa ctgtttctcg ttttagggtg agatatctat tttattgttt tgtcttcttt 154920 gttctctctt tcctgactga gtaacaatca atcattatta aggtttaggt aaattgagtt 154980 ttttcatgtc ctgtttaatt tacttttctc tgatttttag ttgtgtatct ttctttctgt 155040 tctgtaggcc aggacctgac acatttcttc ctgaatgact accatagctt ctcagatgta 155100 tccctaactt cccactctga cttttttttt ttctaataca tctgaaatat tcctcacacc 155160 aggcacttcc atcactgctg taaaacgtaa tatatccatt cacttgtgtg ttcctttgct 155220 tcagttttca gaactctacc aaatctccca gcaccacctc aggtatacta agattatttg 155280 gaatgggatt tcatcataga gccattgcca ataatccaag tgtttccttc cgagcatgtg 155340 taacaagtca tcctcttgct agacaattca tcgctagaat atattcagtc gggattttat 155400 tggatattac cttgtactat accaatgttc taattgtaca ggttatctct taagtataat 155460 gctaagttcc cagaacgtat ggtctaaaaa tatctttttt tttattatac tttaagttca 155520 gggatacatg tccagaacgt gcaggtcttt tacataggta tacatgtgcc atggtggttt 155580 gctgcaccca tcaacctgtt atctacgtta ggtatttctc ctaatgctat ccctccccta 155640 gttccccagc ccccaacagg ccccggtgtg tgatgttccc ttccctgtgt ccatgtgttc 155700 tcattgttca actcccactt atgagtgaga atatgtggcg tttggttttc tgttctgtgt 155760 tagtttgctg agaatgatgg tttccacctt tatccatgtc cccgcaaagg acatgaactc 155820 atcctttttt atggctcata gtattccatg gtatatatat gccgcatttt ctttatccag 155880 tctatcactg atgggcgttt gggttggctc caagtctttg ccattgtgaa cagtgctgca 155940 gttaacatac gtgtgcatgt gtctttatag tagaatgatt tataatcctc tggggatata 156000 cccagtaatg ggattgctgg gtcaaatggt atttctggtt ctagatcctt gaggaatcac 156060 cccactgtct tccacaatgg ttgaactaat ttacactccc accaacagtg taaaagcatt 156120 cctatttctc aacatcctct ccagcatctg ttgtttcctg actttttaat gatcaccatt 156180 ctaactggca tgagatggca tctcattgtg gttttgattt gcatttctct aatgaccagt 156240 gatgatgagc tttttttcat gtttgttggc cacataaatg tcttcttttg agaagtgtct 156300 gttcataccc ttggcccaca ttttgatggg gttgtttgtt tttttcttgt aaatttgttt 156360 aagttctttc tagattctgg atattagccc tttgtcagat gggtagattg caaaaatttt 156420 ctccctttcc gtaggttgcc tgttcactct gatgatagtt tgttttgcta tacagaaggt 156480 ctttagttta attagatgtc attcgtcaat tttggctttt gttgccattg cttttgatgc 156540 tttagtcatg aagactttgc ccatgcctgt atcttgaatg gtattgccta tgttttcttc 156600 tagggttttt atggttttag gtcttaagtt taagtgttta atccatcttg agttaatttt 156660 tgtataaggg gtaaggaaag gggtccagtt acagttttct gcatatggct agccagtttt 156720 ctcaacacca tttattaaat agggaatcct ttccccattg cttgtttttg tcaggtttgt 156780 caaagatcag atggttgtag atgtgtggca ttatttctga ggcctctgtt ctgttccatt 156840 ggtctatatc tctgttttgg taccagtacc acgctgtttt cgttaccgta gccttgtagt 156900 actatagtta gaagtcaggt agtgtgatgc ctccagattt gttctttttg cttaggattg 156960 tcttggctat acaggctctt ttttggttcc atatgaaatt taaagtattt tttttctaat 157020 ttgtgaagaa agtcaatggt agcttgatgg gtatagcatt gaatttataa attactttgg 157080 gcattcaaaa atatcttttt atattgattg tattgtggaa taattttcca ggcacccaac 157140 aagtactaaa aattaattgt tgataccaga aaatgctatg attgaatttg agaaacatga 157200 tgtctaaata aatttagaca cacagggaag gtctttctat tttaggaaat cagacagttt 157260 cctaatgtga cccaatgtct cttattagaa atgtctccac tttctttcac ctttgtgaat 157320 tcagatattc tggagtagtt tccttgaaag tttgagctga aaagtcatct aatttcccta 157380 tctcaatgcc ttcatttcaa aagtaaggaa attataggtg attaatccga agcttatttt 157440 catcactaaa atactgtaac tttcaagtag aaatttttct aaatgaggaa tttttaactc 157500 atagatctaa atatattaag ttaattttaa aaatatctaa accctctctg aataggaaat 157560 tctgtgcttt gttactgaat aagagatgta catttaagaa actggatatt ctgatttgct 157620 acacaaagag ggatataaat ctctatctac ttaaatataa tgtgtctcta agcaaataaa 157680 tagacatcat caccttctca tgccctgcaa taaagagttc tggttcattt agcagtaaaa 157740 gcatttctgt attatacttt ttgctacaat gcttgaaatt tttactcttg cttcagcact 157800 tcctatttca atatcatctt ctctacctat ttttgatcca tacccttcgg aagaagaaat 157860 aaaaaaatta gactatccta tattaagcaa gccaaattca gtgccagaac actataaaaa 157920 gtctttcttg agttcagttg tattgattga gaaatcattt attgtctggg ttttttctgg 157980 accaacattt aggaaattat ggttctccat ggttatatat aaatgttgtg atattgacca 158040 ttacaaatac agataggtct ctttgtacat ttttaaactt agtttcaagg tctatacttt 158100 acaatttgct attttctctt tgattacaac agcgattact gtgtatttaa aatttaaatt 158160 acagaaagca taaagaaagt aaaatcatgt ataatccaac tacacagaat aaccatggat 158220 aacatttggt acgacattct ttcggtattt tatgttataa tacctatgtc ttttgaaaaa 158280 taaataaatg ccactttatc aacctatagc tgttgccaca aattctgaaa taagagtatc 158340 taaactatga ctttgttgtg ttagatatga gtactatttt gttacaaagt ttcccaaatt 158400 tttatagtct ctctctctct ctctctctct ctgtctctgt ctctcaggac aactagactt 158460 attaatgaat cggttcttac aattggtaga aagtgggtga tatcaacagc aaggctttat 158520 ggttctaact ttgagagaca gatttacatt gctcttcata tcacatgtat gtgttatcat 158580 tctggactcc cattttggag aacagtacct ggcacctatg gacattcaga tacatatttt 158640 tttcaatgaa tggatgaatt ttgaattgga gggaaaggag gtctggctct tccattctgg 158700 cttcatgaaa tttctgtgca ttggagtagg tactgcattc caagatctga cacatcattg 158760 aacagagtca acaatagctt tatgacttta cctttgtgaa ctaatcgtga aaataaattc 158820 attttaccaa tctctaaaag gaggaaatta cttttgaaaa aaaacacaga aaaaattaat 158880 ttcctgtagt agtagcaaat gacaagtgtc aaagagttaa gattttcaga aatttcttta 158940 tctctcatga cttttgtttt ataaggcact gtcttccaaa tgcatatagg aaagttaagt 159000 aatagaagga ttccttttaa agtaaaaaaa aaaaaaaaaa tcacagaccc caagtcttga 159060 cttgaactct ctttatgtaa tttaaacacg tatacactta caactagttg caagctactg 159120 ttatgcttgt agccaacatt taattttaaa atctaagttt aaattggctc caaacaaact 159180 ataaaacctg taacattcca attagcaaca ttaatggggt gatttttttt ggtccaaatt 159240 catccaacac gaacagtatg aatattatac tgactgctaa ggcatgagtt tttgggtagg 159300 gctgaaggag aagtctgtac atttttctat tttctcttaa attgatttag ttattgaaat 159360 atacatagag aacagtgcat agttcataag catatggctt tctgaattat cacagatgaa 159420 cacctcgtgt aatcatcacc agaacaaaaa ggagaatatc accataagcc ctgacatttc 159480 ccttgtgcct caattcaatc accactctca tccttcttcc taaaggtcac ccaggaatag 159540 tttgtgtgtg gtatatttat actactgcat tccgcatcac tacttgacat acactgcttt 159600 ttttttaact acaataaaag ctttattttt acagctctct acagtccatt actggaatac 159660 gaatatttta cacttaacta tcactttatt tatttttatt ttgcctctct tgttttaata 159720 aattcatttt cacaaattaa aaattctcag aaatgagcaa taaactttcc cataatccta 159780 ggccatagag ataatcaccg tataaaagac tactgatgtc ttactttcct taagttttct 159840 aaaaattgtt tttaatgatt aaataaaaag gattttatat atacaaaaca atatatgtga 159900 tatacattag catgataacc ctcagtcatg ctctactctg taacctgaag ctaaactgta 159960 ccaattccaa agccctatgg gcgttttcct gatctcatct cctatctccc cttctttgga 160020 gtattagctc tttaattttt atggacattt tataaagtag acactagtat tacagtcact 160080 taaaagtgag taaaggaagg cttagaagat ttaataactg acacccgcac agccaataag 160140 tgaacgaaac ccaagaccct gactccagaa tcagacttct aatgatatgt atttacattt 160200 ctattagtat aatggcagct tcccaataga ttataagttc caggagagta gaacacagat 160260 gtgtcttgtt cactgctgta acccctagtt actggaactg agtctatatc taataaatag 160320 atgagtagat ggactggggc tgattattta tttacatata cattttgtag acattcagct 160380 attgctacgg gaaaaacaaa aaacataaaa agacttgagt ttctcctgtg ttgtatatgc 160440 acatcacata tatctaactc cttttctttc tccacgagtc ctattcactc attcttgccc 160500 agcaactgtg tcacctcttt ctgctttttc atgtgactcg gtttgtatgt tgctcttcac 160560 catgtcttcc ctgccttctc ttcctcttca agactttcag actgctttga ctcaggtgaa 160620 aatattgtta gagggagggt ggcccactac atgatcatac ccacccttcc actcttctct 160680 gggaataatc atggtactgt tctagtaaaa attgcttctt tttctgcttt tgtccttcaa 160740 agtgaatcag cacaaaatat tgagactgca atgttaaata ctgtaagccc ttaaaattgc 160800 agaacataaa ttagtcacat attgccattc tttatctaga aagatgccat attctttatt 160860 gatttagttt ctgcagcaga tttaaatatg gcgtgtgttc cacttttata aaacaaaact 160920 ttattgcctt aaatttgtaa attccaaaga cattacaaac tttaaataca tttttagaaa 160980 ggttcttcaa aagcacatta attcaaattc agaaagatgt ttcagaaggc caagtaaaac 161040 agagaaatgt ggggtgtaga aataaattaa gcataataca ttaattaaca caaagctgaa 161100 ccctgccttg tttttcaccc tgaaagatag ataattaaaa acaacactgt aaagcatttt 161160 tcatatgact ctcaggttaa tgaatggata agaaataaga taatgatata aaggaaaact 161220 tgaatgtgaa actcataaca aaaaagcaag atgtgcatac tttgatgttg ttattctgta 161280 tttaactcta aattgatcct atatttcaaa caactgctca gagcgtttca gtaattagca 161340 catcagggat gcattagtat agaataatag tcttaacttt aggagttttt aaaggtttaa 161400 taatccctct tcccaaaagc ataacatgca aataatttaa attaaaacaa tatatctcaa 161460 tcatctacca atgcactcta ctctattatt aaatacacac aaacatataa gcctactcat 161520 gcgaacctga aaatattaga atattaaaat tgttgaacag ttctctggga tgactgaaga 161580 tatgaataca tgatagcaac cctttctgct ctaactatac aagcaagatt gctgttctga 161640 gaaagtattt tctatcaatc ttatttagtg gggtctcttc tatttcctta catctcaggg 161700 acttataatc aattttgcta aaaagagtca ctctgtttct gaaatcttac attccaggat 161760 aacatgctgc tctttccagt ttcacacctg tgacctgtta tttcaaattt tgcctcagca 161820 ttaaagtaca tttctgaaag ttcatgttgg aatataaatc tcctggattc aaatatcctg 161880 caaaggcatt ggtgacaatt gtgtatattt gaaactcttt ggtcaatttt aggtataaat 161940 atgtaatcat gatctttatt caatctcaag gcaacagact tttctcactc tacctttgga 162000 taaatatcct atgtaaggca aatattttcc ccattcccta aacatgctca gtacttccta 162060 ggaaaatatg accaatcaca agaattttga aagagttcct gggctgtgat caacaggaaa 162120 ttaggtcacc tgattcaaac atatgtatcc aaatctgtta atcataaggg ttaaagaagt 162180 ttcttactct catggactct aaagcaaaat ccacacagaa aaagacccca gaatattcgt 162240 ttgagtttga tatgttctct aatgttgtca gtgaagccat aattcttagg gtgtcctctt 162300 tctcagatta ttctgagatt attggtagac tttatacaag gcccttctgt ccaatatgtg 162360 tggagtcacc atgaggagat ttttattaga catagaatat ttttattgtt gatgaaaatc 162420 tttgatcagc tatcagttgt tcctttggtt ggattttgag ctccatctag ttcagggata 162480 tcatcattcc ttagcaatgt tatcaatgct tcaaactcaa gtcaactaaa tgttatgata 162540 agagtagcta tcatgtattg agcttgtaca acatgtcata ttctctcctg gggaatttac 162600 atatatagtt tcttactctc acaagataaa ttttgttaag aaagtgccac attaggaaaa 162660 ttctcagcca tcatgtgatc tagaaatagg catctgtcaa tatttcatac atacgcacac 162720 agacacatac acacacgtgt atgtatgtgt acatacatct acacatatat taattaaatg 162780 attacagtgc tttatacttg tttaacactt gcatatttac aaagatcctt ttaattacag 162840 tgttttaatt tatcctcaaa ataacttgat aacaatccaa tagaaaaaaa tgagcaggaa 162900 accttaagct ggcactttaa aaagagacta ttcaaatgga caataaatga atagatactt 162960 actgggacaa agcaaattaa aaccaaaaag tgatagaact acacatccac tgggatggct 163020 aaaataccaa atatttgtaa gaatgtgaag caactaagat tcccacaaac tacttgatgt 163080 gactgtaaat tgataaaccc gggttggaaa gatgtttgac agaatctact aagctaaaca 163140 catttgtacc gtatgactca gtaaattcca ctgaaatgca taatatgtct gccaaaagaa 163200 actacaagag tgtttatata agcattattc ataatgaccc tgaattggaa actacatatg 163260 ctcatctaga gtacaataga taaacatgtt gtagtatact gtggaatatt atatggcaat 163320 aagaatgaac aaactacaac tccatgcagt ggcattgatg gctctctcaa atgtaatgct 163380 gaataaaaga agccggcaca aaagagtatc tgagggatgg ggtcttgaat gaggtatgaa 163440 ggattcttct tcagtgttga tggcactctg tttcttaatt tggctgttga taaaatagat 163500 atattcattt tgtaaaaaat tcactaggtt atgtatgaca attggctgac tcctctgtgt 163560 gatacacttt aataaaatgt ttaaaaaaat aatgtgatga cactggcaaa atgcgtatga 163620 atcaatgaac gaattaatgg ccaaacaata aaacaaacat ttttgaggta tatattccca 163680 aatctctata ttttctgcta cttaatctgt tcaaaaatta ctagcactat ggatttgctg 163740 tgattgctgt cctttaaaat aatcatttta cattcagtta attaaattgc ttaaaacaat 163800 tacacaagtt aagggattat tgatattaat cagcacaaaa taataaacta atttattatt 163860 attttaacta atttaaacta attccttaaa aaatcatttc tacatttaag ctaagttagc 163920 aaattttttt cgtaaatgat atccttgtaa actcatagat atgagtaata tttcccaggg 163980 aagcattaag catgcaaaac aagaaagtga gtatgattct atcacaaaat ggacccttat 164040 gtggtagtac agaatagaga aagcttttct gtgaagttac actgggggac ttcattttta 164100 tttcaaattt taaaaccata actgtagtaa ctattggagc tctccaaggt acttctgttt 164160 gcaccattta gttttgaatt tctttaaaaa ttgcctcaaa agttccagag gatgtcaact 164220 ctgacagttg tgcatctcct agacattgaa atagaaattg aaagtgcctt gtttgctagg 164280 gaaggttcaa ttggttcttt ctattttgtc ccttttcaga tactgtttta atgcaactgt 164340 gtcaatggaa gtagaggaat tggaatgttt ggtatttctc ttgattggtt ccctaagttc 164400 tgaatcccaa atgctaaaaa gtttataatt atttcagaaa caaataagaa catgaactat 164460 acctgtttta ccataacgtt gctatctgtt taaacccaac agaaatttgg aggtgccgtc 164520 aatgagattt accaagagat tacttcataa ctttcattgt tatctttaaa accttaacaa 164580 acttttttat atactaacat gctttcctgt aagtgaagca gagccttaga ggtaaatcta 164640 cctggctgca tggaaggtag ccttttagca gaatcactat tacaatgtat tcaagcaaac 164700 actgtgtctg cttttaggca ttcaagttaa tttaaatttt gaagaggagg tgtttaggaa 164760 aggacatgag agttaaatac aggaaggttc agcactgcct tcttatcaaa ccatctctgt 164820 cccagatagc atatttctaa ttttgaaatg ctattaccta tgtatttaat atagtaattg 164880 aattccagca gtaaacagac atataacttc ctagaatctt aaattatttg tatacactat 164940 taattctaat attttgcatg ccaccttcat gatttttgcc atacaaaatt ttgcttattt 165000 tttgaatttc agtaaaataa ttaacatgta taaaatagta ttttcatatg taaattacag 165060 aaaatacgca agtatccact actcagctta agtagtcctc cctacctgat gtacttctgt 165120 gtttataata attctcattt tttaaaaagt aataagatat cagtaaacca tatggttaca 165180 tttgaatggc tttgaattac atatcagtgg taatatattg catcttactt tgtacctgca 165240 tatttttcac tcaaatgact gctctaagat ttaccttgta ttgatgtgtg tatcaatagt 165300 gtattcattt ttattcctaa gtgaaatacc tttgtatgga tacactacaa tttatccaat 165360 attctttaat atacatttat tgtttctagt tttctttttg ctgttccaaa caatcctgta 165420 ggctttaatt ttactaagta attcaaaatt atttttccaa gtaattgtat caatttattt 165480 tcttcaggag tccatgggct tcctttaaat ccacatatta tcaatgcttg atgctgtttg 165540 gcttcttaat tttggatcta cttaatgaat ataaaatgct aacacatttg agctctgatt 165600 tgcatttcac ttcctaataa ttgtgctgat catctcttag tattttagtg tatcatatat 165660 aatatatcat ttgtttgttt tgtttttgtt tttccatcca tcagtagaac cagaacataa 165720 tatatcttgt tctataaaat atctgctcgt ttttcctatt ttattaggct gtttattgta 165780 gtcttaatta tttgttagtt atttgctata aatacctttt tccaatttgt agtttgtcat 165840 tataaatttc ttgagttgtg ttttgatgaa taaaaggtgt gtattataag aatcatattg 165900 atcaatactt tctttcatga ttaatgcttt tgaagtcttc attaataaat ctttccttat 165960 tgcaaggtca taaagatatt ttccaaatta tcttctaaaa cttttacagt ttgcctttca 166020 tgtgtgatct ttaatctacc tagaattgat ttttcagtgt gctttgaagt atatatagat 166080 gtttttctga gtaaaatggt ctgtcttttt atgcactgat ctgctgtgcc ttttctgttc 166140 tatagccatt tttcttatgt atggaaatgt ttctgtaatt tctgttttgt tgaattgctc 166200 tacttgttta tgtctctgct atatcatctc ttttaattat tatagccttg acatgaatat 166260 tgatatctct tggatagatc ccctaaattt attctttttt aaaatcagtg ttcaagtcat 166320 tcataggctt tttcatttct ataaaaaact aagaataagc tttttaattt cacaaagaac 166380 acttgttagg gttttattgt acttacatgg atctgtggtt caatttagga agaagtagca 166440 taatgaagat attgactttt tctattcagg aatgtggata ttgttccatt tactcagatc 166500 ttcttaaatg cctttcatta aaatttaaaa tcttttcccg taaaagtttc acacgtctct 166560 tattagatta tacttaatta ctcaataatt ctgctactat catttttgct tcattctcta 166620 acacttttat ctctagtata tataaatgtg attgaatttt atattaatat gtactcagca 166680 aagatactaa actcttatta attctaaaaa tttatctttc caccttcctt gtatataaat 166740 gtgtcatctg caaattcttc tttttcaatt catgttcatt tttcctttac cttactgtgt 166800 aggctagatt atatttacta gcaatgatga ttgtggacat tttttcttgt ttccaatctt 166860 taagataaaa tttatatttt atcactaaaa aattgttaag tacttatgta agtatgtttt 166920 gttgttttgg tttggtattt tggcagatag cattaaggaa ttttcttcat tttctaattt 166980 gctaatttcc tttgtaaaaa aatataagta gatgttaagt tgtaatgatt tttagctcta 167040 ttgaagatta tcacaaggtt ttgctgcttt aatttgtttt gctgcagtaa ccaaaaatcc 167100 aatgtcttgt tggcttccaa caaaaacact catttattcc tcatgttaca ggattgttgt 167160 atgtcaaata tatatggatt gagctccaaa tttctcccct ttccaggggc catactgaat 167220 gagcaacccc taactgggac attgtattcc catggcagaa agcaaaagtg caagggagaa 167280 aaccaaatca tgcaattggg catggtgttt tctatttctt cacattctat cagccaaagt 167340 aaatcacgta gccaaatccc agaccctggg attaagaagc atgacagggt agggaaagaa 167400 taaattactg tgactagata atacaatctg atatgtggtg gattctacta attgatttct 167460 taatgtcaaa ataacatttc tgggattaac ctgactgata atgttgtttc gtccttttca 167520 tacattgcta gatatgattt gctatatttt acataaaacc atttgctata ttttatataa 167580 aaccatatat ccatgagtga tactgatctc tattttttct ttctactact gcccttctct 167640 ccttttggca tcagtacaat tgtagtctag aaaaaataaa tatttatata atccttttgt 167700 agaatactct gatagaattt gcaaatattg caaatatcag ctattttaaa gtttggtaga 167760 attgtaaaca ttcttggttg catgtggaac tattataaag tattgataca accttttaat 167820 tattatcgtc ttttcctcca tttattctta aatcaattta gataagctac attttactag 167880 gaattagtcc agtgcatcta aatttgcatt ttattctcaa aatgtttggt ttattgtctt 167940 gttatttaaa ctatcacatc agtaaatttg agctgttttt ctttcttaat tttgtttatt 168000 ggtgtgttct tttattcttg aaatactaga atttgcctat tttattgttt tattttaaag 168060 aatatttggg cttactttta aatatcatat tttaatattc tgtgtaataa ttcatcatat 168120 gcctggtaag gagaatttaa gttaataaaa ataaaaaact tagaacaatg ctcagcatac 168180 agtaatcgct atgtgggtgt cagccaatac tattatttct attttttctg ctcttcattt 168240 cattaacatt tgttattatt tcatacattc ttaagtttgt tgctgagttt attcatcttg 168300 tttaaataaa taaaaatatt tagtgttatt acactccctc taaatactac tttagctgta 168360 tcctacacgg ttttaactat ttttgttatt ggtcgttttc aagtattttt aaagtttcat 168420 tattgtttct ttgagccatg agttacattt acaagtgtgt ttctaaaatt ttcaagtatt 168480 tgatcatctt caagttgttt ctttactaat gattgttaac agaatcattg tgatcagaaa 168540 atatggtgta cataaactca atctcttgaa atttgctaaa agttacttta tgcctattat 168600 ttagccacct tttgtaaata tttcatgtag atattggcaa tgttttgtat gtttcattaa 168660 atcaagctgt tatttttgtt tgtcaaatgt tttgtctaaa tatttttgtc tgcttgaagg 168720 atcagtactg tgtaggaaaa tctcccacaa cgataatgaa ttgatcaatt tttttcctgt 168780 ggttctgtca atctttgctt tatgtttatt gaagtatatg ttagttacac gtcattagtt 168840 acatgtaatt ttttcgttat acttcagtaa atttctgctt tatgtttatt gtgctatctc 168900 attactatat gtatgtttat agttgtttaa agtgaattaa attttaatca tatattttga 168960 acaattaatc tccagtttct ctagtatctt tagatattgt tttaggtctt aaacctatat 169020 tatttgtaat aatacagcta tatcagcttt cctttgattc aatttacttg gtccttcttt 169080 ttttattaga gcatatttat ttcttttttt tctctttttg aaaattttta tagatttagg 169140 agctacagtt gtgcatgtca tgcagttatg ttacatagat atattgcata gtggtgaagt 169200 ttgggttttt agtgtaccca caacccaaat agagaacact gtaccaaata ggtaggtagt 169260 atgtcatccc tcagtcccct ctcactatcc caccttttgg agttgccaac gtctgttatt 169320 tcactttgta tgtccatgtg tactcattgg ttacctctca caaataagaa catgcagctt 169380 ttgactttgt gtttctgagt catttcactt aggactatgt cctccagttc tatgcatgtt 169440 gctgcaaaaa aaaaaaaaaa acatgatttc atttttttaa tggctgaata gtaatccatg 169500 gtatatatag tccacatttt tcatccaatt atccattggt ggacacttag gttgattcca 169560 tgattttggt attgtgaata gtactgcaat aaacatatta gtctaggtgt ctttttgata 169620 aaataatttc tttccttttg gatagatatc cagtagaaat gatggttctc ttttttgttt 169680 taagagatat ttccatgctg ttttccatag atgaactaat ttacatttcc accaataggg 169740 tataaatgtt cccttttctc tgcatcctca ccaatgtctg ttgttttttg actttttaat 169800 aataaccatt ctgactggta taagttggta tctcattgtg gttttaactt gcatttctct 169860 gatgattaat gatgttgagc attttttttc atatgtttgc ttggccactt atatgtcttc 169920 ttttgaaatt tttgtatact cttttacttt aacttgtatt ttcacttctt agtctgataa 169980 tctttttctt taagttaaat ttatcatgat tactgtttta tttgttttat ttctttcacc 170040 ttattttatg cttttgattt tttccacctt tttggaaatt tttttccacc tttcttgtgt 170100 tttttaaatt agggtttttt ttggtcttat ttcatttttt tctacattaa tatttagcaa 170160 aactaatcat tacaggttat cctaggaaat gtagcctaca tagcttattt gacaaagtat 170220 gaatcttatc actgtctcac ctgcttcctt aacaataaca gggcaatgga aatgtaatta 170280 cctcccaatt tatatcctat tattttctag taatttaaat ctattattta cctttgaatt 170340 gtttatacag tcaatatttt tccttttttt tttttttttt ttttttgaca gagttcgctc 170400 ttgttgccca ggctggagtg gagtggtatg atctcagccc actgcaactc cacctcccgg 170460 gtttaagcga ctctcttgcc tcagactccc gagtagctaa gactacaggc atgcgccacc 170520 acacccagtt aatttttgta tttttagtag aggtggggtt tcgccttgtt ggccaggctg 170580 gtctcaaaac tcctgacctc aggtgatctg cctgcctcgg tctcccaaag tgctgcaatt 170640 acaggcatga gctaccatgc ctgaccaact ggatatcttt tctaataatc ccttcttgca 170700 tttgcatttc aaacattctt ttgggagtca attttcttct tttgtttgtt tgtttgagac 170760 cgagtttcgc tcttgtcgcc caggctggag tacagtggcg caatctcctg ctcactacaa 170820 cctccacctc ctgggttcaa gtgattctcc tgcctcagcc tcccgagtag ctgggattac 170880 aggcacgctc caccacacct ggctaatgtt tgtattttta gtagagacag ggtttcacca 170940 tgttggccag gctgctcttg aactcctgac ctcaggttat ccgcccgcct cggcctccca 171000 aagtgctggg attacaggtg tgagccaccg ctcccggcct tctttcttaa gcacatactt 171060 tagacattac ctcagcacta ttgacatttg ggacgagaca attctttggg tggggggctg 171120 tcctatgcaa tacaggatgt ttagcagcat tcctgacctc tactcactag atgctagtaa 171180 ctccagttat tatgatcaga aatgttctag atattaccaa atattctcat attctctgaa 171240 tgagcggtgc aaatatgggt accaaaaatt actcccattt gggaaccact gctttaaaag 171300 tgtccttgtt attaaactct gtcttgttct tttgagagca atagcaaaat agaaaccttt 171360 ccgaagagtt gtacacctcc tagatttata attctatgtt gagagttgtt ttctttcagc 171420 aatttgaaga ttcattccac tgatttttgg cttctgttgt tgcttttgaa atactattat 171480 tcctttgaag ctaatatgtc ttatttaact tgtctttgga gtcctgcagt ttttcagtga 171540 tgtatctaag ttacatcatt ttattaatga atgtaagtca gtctacattt tatttgctct 171600 acattggatt cattttgact tttgagttta aacagtcaca tctttcaatg cttttagaaa 171660 actctaaaat atcttcaaaa atctaaaaaa atctaaataa tccctttaat tattttctgc 171720 ttatctttct ctatgaccct ttacttgata tccacctgaa catataactt ctcactctat 171780 cctctataat tcttaagctc tttcagattt taaatctttc tgaccatcaa ggctgccttt 171840 tcgttacatt tcttatatct accctctaat ttttaaaatt acctttagct gcattatctg 171900 ctattgaaca catctattaa gtttttaatt tcaagtatta catttctaat ttccataaga 171960 ctgttctttt ccaaatttgt cagccatttt aaagtttcta aatctttgta tgtacttacg 172020 atggttttta catttgtaag caaaataatt atagttgtct catagttttt gacaggtcat 172080 cccaatactt aaaatatttg aaattgtaaa gcttccatcc tttttttcct actgcctttc 172140 attcatgata ccttattctt gtgtgtgttt tgtgagtgtg tgctcatagt caatataact 172200 ttatctagga gaacattatg agcccttctt ggaagattta ttttcttttc caaggagaag 172260 tagttcctgc atacgtcaag ccctagggaa agctaggtga aaccctgtat cacttttgtt 172320 ctgtatttgg cattttacag atggctcagg taacttaatt tgagtcacag ctctacatca 172380 gtgatggctt gtgattttta gttctcatga aaagtcttgt ccttcctcta cctggtaaca 172440 agctaaagga aaaaatattc actgtgtact tctgttgagt gtagtttact ggaagcatag 172500 tctcttgagg ctctaagttt caagttgtca tattttcaaa gtttggtaaa ctctagattt 172560 tatgtcttgt tatctacaca gtgagcaaat gttcaaattt aagcccacca taaacatgga 172620 ttggtagatg acctcagggt agctgtcaag ttcagataat agttaccttc ctagattctt 172680 cctttccctt attttggctt cctggtattt ttcctacttt cttgacatct ctgcaataaa 172740 attaaaaata tcataaaaga attcaataag agcttttagt tattttgaag catgaacatt 172800 aatcacagag tttttctgat atactgttga aaatggaaat caattttata tgcttttaaa 172860 aactagctta tataaataaa ctgaagccta acaatgttat ctactttaat catccaataa 172920 atatttattg aatatataca acattctact cactgtttta agcatttaac atatcatgtg 172980 acagaacaga attcatgcct tcaatgaact tagtatattc tagagggagg aaataaaaca 173040 acaaacacaa aacaagtaca taaaaagagt agctttggac accaaagagt gccataaagc 173100 aaataaagca aggtgatgta gtggagttat ctgagacaag ggacctgatt tatctaggaa 173160 ttggaaccag tagatctgaa gaattaaaat attagtgaaa cctgaataat gagcactaga 173220 cactcattca aaggggaagg gtattccaaa cagaaggaat agcagttgca aaagttctga 173280 gatacatatt agtttgagtg tttgaggaaa gaaatatagc agtgtaacta attatagaag 173340 atgaagagat gagtagagga atatatggtc agaggtaaag gcacaggaga aataaagtat 173400 ataggccatg gtgagggatt tggatatttt aataagttga atgtggaacc actagagtgc 173460 tttatacatg ggagtagcat gatctgattt acacttctgg gaaatccacc tagctgatgt 173520 atgaagaatg gatggagtcc gggcatggtg gctcgcgcct gtaattctag cacttcagga 173580 gactgaggca ggaggatcac tggaatccag gagtttgaga atagcctagg caaagtagtg 173640 agaccctatc tctatgaaaa ataagaaaaa ttagctgggc attgtggtgt acacctatag 173700 tcccagctac tcaggaggct gatgttggaa gatcgcttga gcccgggagg tcgaggctgc 173760 agtgggccat gattgtgcca ctgcactcca gcctgggtga tggagtgaga tcatgactcc 173820 aaaaaaaaaa aaaaaaaaga aaaagaaaaa agaatagact agaaggtata gttctgacga 173880 aagagtggaa tggataaagt tttgagagaa aatatgcaaa taagaaatga tggtattcaa 173940 caagaaagtc agaggacatg gcagtgacta aagatcaaaa taaaagaaaa gataattttt 174000 aatgaccaga ggaactaaaa ggccaggctt gggatggaca gtggaaatcc tccaagaaca 174060 ctggcagaga tgtcagcagc ttgttgctga catcatccat aaatgatata atgtgatcaa 174120 gaagttagca aatgacaata aaaagaagta aaggatggta aaatttgata aggtgcttta 174180 aaggagttgt tttttaagga ggaaagggta gagacaggaa ggaccagtag tggacaaata 174240 aaacacttat tgtagctaca ggtcctaaag gcacatgagg tnnnnnnnnn nnnnnnnnnn 174300 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nccctaggtt ttatttgaac atagcagggg 174360 aacaatagtc tcaggagaga tcaagttttc actaagagta tggaagtgaa gaaaatcata 174420 gatgagtttg aagatagaag gacacgttct ttggatgcag tgagaattct caaaagtatt 174480 gtgaaatggt ttaggaagga agttgtgggg aggggcgggg ggcagaattt attagggatt 174540 gtatggagta tttggaatat ttggaagatg ataattaata agatgttaga gaatccaaga 174600 tggttgagct tctagcgctg ttggaagtga acagaagtgt gaggcatgat gacattagtg 174660 ctgaaaatta gggaatatag aagtgattgc aaaccaaggg acaactggcc tccctatttg 174720 gtttaagttt agttgccttc tagagcacaa ggtaatggag gatctaaact cctaaactca 174780 ttctaagcaa taattttcat gaaaggatgt ccttgatgtg gtaattcttg ttattctctt 174840 aatctacact aaaataaaga atataattat aaaaatgaaa aaaagttttt ctctataccc 174900 ttgaatcgct atcagtgtta tatgtgtacc atgctgtgca aaatactagt tttcacatac 174960 cttatcacat ttgtgaatgc tttgaagcag caaatttgat gagactaagg aagaataagg 175020 aggctagtta gagttggtga ggaaaaaata tgcaaagaag cgaagatgac tccctgcata 175080 gtttaattga atttaattag actaaagaaa attaatcagg gcataggatc catgtagcaa 175140 aatacctgat tattaaatca ttggataatt agaagtagag agtgatcaag attttcttag 175200 taacaaccca agaatgagtt gcttatacaa gatagcaggt taggaatagt ctctcttttt 175260 ctagtttgca acagttttta ttagtattta gaaaattttt ctatcatcag ttttttagag 175320 aggtattaga aaaagaactc catttacgaa atgacaaatt tagttttttc tggtaatttc 175380 acatttttgg tgccaaacat aacttttcat caaaatacat aaaaaatacg ttagtgagct 175440 atatttaaaa tcttgtgttc ttagagtcta tgtaagtttt taaaatctca attataaaca 175500 agctcattct tatttgtaga caatccaaaa tcctctactg tgactttgga tttattcaat 175560 atacctataa taaaaatgag gattttgttt gctttttaca ctcaatagtg gtaagacaat 175620 aaaagaatac aaattgcaat ttgacatgac ttgtgtgata gaagattttt tcaagattat 175680 tttaaatcat ctgtgttctt acagaattta taaaaagaaa tgagaaatga agttcagaat 175740 acatatcaaa attgtgagca aaatccaaag aatttttttt cacttttcat aatgctttta 175800 taggaataga agtacacttt caaagttaat aataaatgat tacaaaatga gttgagtatg 175860 actagttaag aaagaagtag agaaagacca agagtgatat tcaaaatatt taacatctcc 175920 acatctgaac tagccatagc tggggcctga tgtaaacaag ttttagccct ataatagtga 175980 tatgtccttt gtgaagggct gggaagccag atcagccata agaagagcac ttggggaact 176040 taatgctgaa tcttttctgt taaacacttt gactggtaaa tacatttttt caatatttaa 176100 caatcagtat gtatatctac tgtatactaa ctgaaaacaa tattgcccat ccctacctaa 176160 tacttctata taaaaggaca tcatatattg catatggaat aactaatacc ttatacaaac 176220 tccaatttat tattgtaatc tacgatattt caattacttt ctctgtctct ccttcctctt 176280 ctcaccaagt ctcatgaagc agtgtagtgc agcaagaaca ggatgcaatt agaattagat 176340 tcagattcac atcccaactt cactatcaac taattgtgta tcagtgggca aattatttaa 176400 cttctttacc attcaatgtc atcttctgtt aaatgaggct tgtgagtttt agagacaaag 176460 aataaaagat atccagcata gcacctgctg tatgacagtt atccaataaa tggtaactgt 176520 tgctactgct ttgagaattg ggaagaaatt gctaacacaa tttttcacct ggagttttat 176580 ccaggattag gctttaggat gtctaagaat cctctaaaat taaaagtgaa agaggttata 176640 tgtgcacata tgcacttctc tggagaaagg gtcaataaca tttgtaaagt tcttaaaggg 176700 tgtcttgaat ttaaaacagt tggaaagaaa aagtgaagac aagttggcag aaagaggagg 176760 gggaatgaca tggaaagaga aagaaatgaa gatcaggggg aaagatggca actaaacaga 176820 ggaaccaatg tggagaattt gcagagaatg cagactatag cattggcatg gtcttggaaa 176880 gaaagttgag ttggtagaaa tgagtagagg aggtcagcta aaaatcagtg aatccggaca 176940 gaaaatattg cagatttgtc atggtttctg cagtaaggca gtgattctta acaaattcct 177000 gggaagctat tatattttaa atcgcttctg tttcaccttt ccttgatact caaaacaatt 177060 tacatagctc aatttattgt aatgagtgtt ttacattgat atttctatcc cattttgaga 177120 catccaagcc atttcatcac tgtaatatta tcatattgtc tgatgctact tattttcaat 177180 actaatatta gggtttgatg aagcttattc agaatgcttt tccctacaca ggttaaatgt 177240 ttagatttgc atttcaattt ctattcactc ttgacagctg atcattttat tatcttgaaa 177300 attttcacag tggggcaaca gttaatgatg gctttctcaa agagcaaact aatcagcact 177360 acatgaaaaa ggagaattta gtgataatca gaatcatgtg ttactgtaag aggaaagtga 177420 aaaagagaaa ttcaacttga atttattgtc attagtaaat catcaagaat tatcatcaaa 177480 atatatccta aaataaagct aaatatgaaa aagaaacaga tgttgatgaa aacataacaa 177540 gaaaaatttc tgcaaatgta aaattttttt ctcaaacaca agaaggtaaa atgtgagtat 177600 tgaaattaat attacaggat acagtgtctt aaaatgcata ttcaacagac gtctgccatg 177660 tgcctactct gtgccaggca caaaactcat agcaatcata ttgtcacttc acaataatgc 177720 aattactgat tttacagatg aattacccat ggctacacaa ccttaataac aactaggttt 177780 accacgaacc tatcatgtgc ttacacttct cattgattgt ctttcatcct aataaccacc 177840 atgtaagaga agccttactt ttatatccct attctcacct attaaataag gccaagataa 177900 ataattggct tatatagctg gaaaggcatc agaggagtaa gaagaaccca agtcttttga 177960 cctcaaattc agtgcttttt atgctatttc atatttattc atttacttat tctcagaaca 178020 aatatttatt gtgcacataa taattgccag gcatttatta aaagctgtgc acacaatcat 178080 ggtgaataaa cattcttatt ccttattcta atggagttta tacactttta ggtgaaacca 178140 gttgtaaaca agcaagcaaa caagggctat aaagaagagt acagtttact gagatcaaag 178200 aaaggagggt gatcacagag gacctctaaa ggaactagct gtaaagagag agcttttata 178260 tgttcctgtc agacagaaga tgtgcaaaga ctctgaaata gcagacagac tagatttgct 178320 aatttctaat gaacacaaca atcaaagact tttttggcac acaggataaa actgtgtttt 178380 tacatagatc atataaattg attgactagt atttcaggta tctgtctgta atttgctttg 178440 cctaaaacaa gcttatttga aaatagaagc atatatattt cacaaatata tgtgaaatcc 178500 acaatagtgt gtaagtagtg tgttaaatga atgcatttta ctgtcatcaa tactacatgg 178560 aaaatcagaa ttttaatgca atctaatttt cttttctttt cttttctttt cctttttttg 178620 agacagagtc tcgccctgtc acccaggctg gagtacagtg acgcgattgt ggctcactgc 178680 aacctccacc tcctgggttc aagcgattct cctgcctcag cctcccgagt agctgggaca 178740 ataggtgcgc gccaccatgc ccggctaatt tttgtagttt ttagtagaga cggggtttca 178800 ccatcttgac caggctggtc ttgaactcat gacctcatga tccacccacc tctgcctccc 178860 aaagtgctgg gattagaggc gtgagccact gcgcccagct taattttctt taaagttgaa 178920 aaaagcatca tacaacaata atatgagagt ttggaattgc tcccttattt aaaaaaacaa 178980 aaaataaaaa ataatttaaa aaacccaaca tcaggacctg ttataacctc tgcagactct 179040 gaaaaagaga tgatgcaata gttctttgga aacatctgtc agtgtcattg gattgctctt 179100 tcttctcatt tccttttcta aatgtgtagt atctccttct caatattaca tgacctttat 179160 cccatgaagt ttatgatatt ttcattacct aaaatagctt cttaccgaga cattttttat 179220 gtatcagaat tcacagatcc ctgtctatac cacagacatt gagcctccaa ggtatcaacg 179280 atatcaacaa ctgacacacc tcatttggat atagggaaac gtttagggtt tttacgcctt 179340 acagacactt tcataaataa tcttctatta catacaatga cctttcatgt tcataaatat 179400 aaataacgct ctcaaaaaat taaagattcc caaccatatt tatttttttc actgtatttt 179460 attaaagatg caatacccca ctttctgttt aacatctgtt ttatctttta taaactttct 179520 ttcttgctat gatctttctt ccacactgaa ttctctacct ttccaaattc ctgttgaaaa 179580 caggaatgaa ctgttttggt aacctcctga aaatttgagg gataaaaatt gattttattt 179640 ttcctaacag gtgaagaccc aaagagtttg cattgacaga gcacttctct attggcaggc 179700 aggaggtagc aactgagcta taacactgta cggttagggc actggaatcg taatattgtc 179760 acattgaatc ttgcattgga atgtatcatt cttcaaaaca ttttgaaaat aattttaatg 179820 tgtggtagtt tcttcaaaat aataataaat caaatatttt aaaagttact gtaagataga 179880 ttccttgtca aataaagggc tatcttattg tacagaactt gttgttaaca atcactggga 179940 agcgtggtat agaggagaca atactggggt ctactggtat ctaataaatt aagtcttttt 180000 ctcagtccca ccttgaagta gctgtatgat aaacagatag tttaacttct catggtgttt 180060 atttcgacat ataccatttt aaaggttgtg ttagatttaa cacattgtaa tatttcaagc 180120 aggtgttttt tgtttgtttg acagtgtata aaaaataact gaattaattt ctaaactgaa 180180 aaattaggag tttttgaaca aatctaacag gcagaaattc cagaatggta tagttgaaat 180240 caacagcagc atcaaccaat tgaatataat taatgtctac agaatactta ttcaacaaca 180300 gcagaataca cattcttcta aagttcacat gggacattca ccagaataga acacattcta 180360 tgccattaag cataccttca catttaaaat aaaaggaatt gtacaatgga tactctcaga 180420 ccacaaagaa attaaactgg aaattaatga cagaaagata actgaaagat cctcaagtac 180480 ttgaggatta aataacacat gggtcaaaca agaaatttta agagaaatta aaaagacttt 180540 gaactaaatg gaaattaaaa cagaatttgt cataatgtgt gggatgcaga gaatgcagta 180600 cttagaggga aatgtgtagc attgaatgct tatattagaa aagaagaaat aagtaaaatc 180660 aataatctaa ttatccattt taggaaacca gaaaagaaga gcaaatgaaa tccaaagtaa 180720 gcctaagaaa agatataacg aaattagagt ggaaatcaat gaaatgaaaa taggaaatta 180780 atagaggaaa accgatgaaa caaaaagctg gttttttaaa gtgagcaata caattgataa 180840 ccctctaggc aggctaacta cataaaaaca gaaaacacaa attattaata tcagaaaggg 180900 aagaggagac atcactacac attccttgga tattaaaaag aaaataatct tccaaaagat 180960 aaaatacctg gcctagatga gttcaatggt gagttctacc agaaatttaa ggaagaaatt 181020 ataacaattc tctatatctc ttcaagaaga tagaagtagc agggatacct tctaatattc 181080 tatgaagcca tcattaccct aatactaaaa ccagatgaag atattacaag aaaaaaaact 181140 agagaccaat atcttttatg aatatagata aaaaatactt caacagaata ttatcaaatt 181200 caattcaaca atgtatgaaa agaattacat gccactattg gccaggcgca gtggctcatg 181260 cctgtaatcc cagcactttg ggaggttgag ctgggctgga tcacttgagg tcaggagttt 181320 gacacaagcc tggccaatac agtgaaacct cgtctctact aaaaatacaa aaattagcca 181380 ggtgtggtgg cgcatgcctg taatcccagg tactcacgag gctgaggcag gagaattgct 181440 tgaacctggg aagcaaaggt tgcagtgagc caagattgtg ctactgcact ccagcctggg 181500 tgacaaagcg agactgagtc tcaaaaaaaa aaaaaaaaga attatatgcc actatcaagt 181560 agactatatt ccagtatgca atatgcaagg ctactttaac atttgaaaat caattaatgg 181620 aatccatcac atcaacaagc taaaaaagaa aagttaaatg atcaaatcaa cagatacaga 181680 gaaagcattt gtaaaaatct atcacttgct catgataaaa actctcacca aactagcaat 181740 agaaggtaac ttcctcaact tgatgaacat ctaaaattat ctaaagctgc cattatactt 181800 aatttcaaga aactagtagt tgttccctct aagattagaa acaaggcaag ggtgtctcct 181860 catgtcattc ttttttggct tgtactggaa atcctaacta atgcaacaag acaagaaaag 181920 gaaataaaag ctttaaaatt gggaaggaag aaataaaact ctctttgcag atggcattat 181980 tgtctgtgta gagcattcaa aagaattaac taaaaaatcc tcctggaact aataagcaat 182040 tatagtaagg ttgtaaaata caaggctaat gtacaaaagt taatcacttt cctatgtacc 182100 aagaataaat gattggaatt tgaaatttaa aatataatgc taattacatt aacaccacaa 182160 aaatgaaatg cttagttata aatctaacaa aatatataca acctctacat gaggaaaact 182220 ataaaactct gacaaaagaa atcaaagagg agctaaataa acgaagagaa accccatgtt 182280 catagacagg aagattgcca acttgatctg tgaaaccagc acaatctcaa tcaaaattcc 182340 agcaagttat ttgttgatat aaatatcaac aaactaattc taaggtttat atggaaaagt 182400 aaaagaccca gaacatcata ttcaatatta aaggagaaga caaaagtcct aagactgaca 182460 ttacccaact ttaagacata ctgtaaggct atagtaatca agactgtgat attgacaaaa 182520 gaataaacaa acagatccat gcaatgaaat agagaactca gaattagacc catgcaaata 182580 tagtcaccta tcctttaaca aaggagcaaa aacaatatga tggagaaaaa cattgtcttt 182640 ttgacaaatg atgccagaca aactggatgt ccacacaaat aaaaaaataa caataattaa 182700 aaaaaaaagc tgagcctgta ccagtagatt tggtgtctgg taagcacccc cttcctggtt 182760 tatagttggc cgtcttcttc ttgtgtgctc ccatggcaga aggaatgagg gtgctctcca 182820 gggtatcatt tatataggca ataatctaat tcctgagatc cccaccctca tcacctaatc 182880 acctacaaaa atccccacac cctgatgcca taacattggg ggttatgatt atttcaactt 182940 atatatttgt aggaatgcca caaacttcca gtctgtaata ccaaagccat ctagaatttg 183000 ttatttgtta tcttctatga gttttatagt ttgcctttta tatttagttc tatgattcat 183060 tttgaattaa ttactgtgga gatcgtaaac ctaaatgaga atggaaaatg gtacagtcac 183120 tttggaagac agtttggcag tttctaacat acacttacat atatccagca atcacacatt 183180 ttggtatata cccaaatgag ttgaaaacat atgtccacac agaaacctgt acacagttgt 183240 ttatagcatc tttattcata attgccaaaa cttgaagcag acaaaatatt ttttatgtag 183300 gtaaacagat aaataaactg tagtgcatcc atacgatgga atattattca gcaataaaaa 183360 gctgaataaa taaatagtaa taaaaagctt tcagccatga aaagacatgg tttaagaagg 183420 tacttaaatg catattacta agtgaaaacg cctatttgaa aaggttacat actgtgagat 183480 gacagctgta aaacattctg gaaaaggaaa aaccatgaag aaagtcaaac aatcggtggt 183540 tgcaaagggc tcagggaaag ggggaagatg aatagagtgg agaacagagg ttatttagtg 183600 cagtgaaact attctctatg aaactatagc gctggatata tttcattata gcttttcaaa 183660 acttgtaaag tgtacataca ccaagagtga acactaacag taaactatgg actttggatg 183720 atgatggtac atcaatgtag gttcatccat tataacaaat gtaccaatct ggtgcaggtt 183780 gtggatagtg gaggaggctg tacttgtgtg tacgttctgc tccattttgt tgtgaatcta 183840 aaactgctct aaataataaa gtatatttaa gtggcagttt tgcataagaa tcccattttc 183900 tagcagcaat ctgctaaagc tgccttagca cctttaaagg agacatgctt tctaaattgc 183960 catggtccct tcttagccca tttctcattt ttcttatctg tagtcatttg aatttgcaat 184020 gcttgagctt gcaataatca gtatttcttt taaactaaat ctagccaaac aaatctctgc 184080 atttttcctt tgtatttttc tactctcctt tgatgctcca cagcaaatat gcctcaaaat 184140 taatcattga tgcaatatgc ttatattgca aaactttgtt ttctaccata tgaccaaaac 184200 tttgttttct accatatcat caaacatgtc aaccaaaatg tagtgtccta ataacatacc 184260 ctgggtgcag tctcatagaa gtggaaagga gaatagttac tttgctactt ttatgctcat 184320 ctctcctttc tcatcatttt cactaaatca gcgtaatgac ttttcatgct tcctcatatt 184380 ctctatatgc tttcgattta tgatttattt tcttacaaaa aatgatggat aagaaagtta 184440 ggggaagtca aggagataga gcaacagaaa actgaatttg agacacattt ctataccctt 184500 actcctcatg tattatgttg tgcatgtgtg tatatataca taccactatt ttatggtctt 184560 tacagacttt atgatctata tagtcttttt atagaatgtt tagaagacta acatgaaggt 184620 tgtatagaaa caagtcagtg gatttattgt ttgtgcttct gtttctctag aaaaacaggc 184680 atcatgtttt acttccaaga cagtatttac aacagactag ctatccacac agatctttca 184740 aatttcaaaa gagaacattt aaaatatgct tgactttcat gttttacaaa atttatatac 184800 agtacaatgg aatctttttg aagggcttga cacataaagt aataatttta agtgattgta 184860 gatgtacata gttgtatctt tttaaaatgt attatattgt tgttatttgt gccaaatagt 184920 tgatcaggga gctgttccta tgagagatgt atactagaga tgtcattgtt attatcatta 184980 ttaaagacaa gtatttttga gaactatcga tgtatcagga actatgctac gaattgatat 185040 gctatctcaa aatatgacca caataattcg ttttttgttt tttgtttttt gagacggagt 185100 cttgctctat caccaggctg gagtgcagtg gcaccatctc ggctcactgc aacctccgcc 185160 tcccaggttc aagcaattct cctacctcag cctccgaagt agctgggact acaagcgcgc 185220 gccaccacgc ccagctaatt tttttttttc tttattttta gtagagatgg ggtttcacct 185280 tgttggccag gatggtctcg atctcttgac ctcgtgatcc gcccacctca gtctcccaaa 185340 gtgctgggat tacaggcgtg agccaccacg cccggccaga ccacaataat tctatgagcc 185400 agatattatt atcctcattt tgcagatgaa gctttagatt gtccaagatt tcaccacaaa 185460 taaatggcag agctgggatt aaaaccttga tctgtctgac tttgaatctc gatgctttaa 185520 aaatattaaa atttcatcaa tatctttaaa aatatttatt acattgaaaa gaggaataat 185580 aaacttttta attgatcaat ttatttttta attgataaaa tgcatgtgtg tataaaatta 185640 tataaattca ttatgtacat gatgttttga aatacgtata cattaggaaa tgactaactc 185700 aagctaatta atgtatgcat tacttcacat acctattttt tcttgtgaga acacaaaatc 185760 tactctctta gcaattttca ataataaaat aaattattat taactgtagt cacctaattg 185820 tacagtagat ctcttcaatt tattcctcct gtctaattga aattttgtct ttgatcaaca 185880 tctcctaatc ctgctcctcc ccttcccctg ttcctggtaa acaccattct actctctgct 185940 tctatgagtt cagctttctt atattccaca cataattgag accatgtaat acttgtcttt 186000 ctgtgcctga cttatttcat ttaatataat gtcctccagg cttatccatt tgttgcaaat 186060 gacaagaatt tccttcaatt taaggctgaa tagtattcca ttgtgtatat ataccacatt 186120 ctctttaccc attcatctgt tgattccata tcttggctat tgtgaataat gctcagtgac 186180 caagggagtg cagatatctg tttgacatac tgatttcatt tctgttggat atatatatag 186240 gagtgaaatt gctagatcat atggtcattc tacttttagt tgtttgaaga acttccatac 186300 cattttttat aatggttgta ccaatctaca taaccaccaa cagtgtgcaa ggttttcctt 186360 ttctccccat tcttaccaac acttattatc tttcatcttt tttataaaaa ccattttaat 186420 aggtaggagg tggtatctcg tgtgggttta atttgccttt ctctgatgat tagtgatgtt 186480 ggacattttt tcatatacct gttggccatt tctatgtttt tttttgagta atttctattc 186540 agagcctctt ctcattttga aatgattgga ttatttattt acttgctatt gagttgtttg 186600 agctccttat atattttgaa tattaaacac atatcaaatg tatggtttgt aaatattctc 186660 tcctattcca taggtctctt cactctaatg attgtttcct ttgttatgta tgagcttttt 186720 ttttggattt catccatttt tctatttttg cttttgtttg tgtttttagg gtcatttcaa 186780 aaaaaaaaaa tcattgctca cactaaggtc atggagcttt tttcctatgt tttattccgg 186840 tagttctaga gttccagatc ttagaactaa gtctttaata cattttgaat tggtttttgt 186900 atatggtgtt gatttaaggg tctaatttta ttcttctgca tgtggatggc cagttgtacc 186960 aaaataattt attgaagaga ctgttctttc ttcattgtat gtttttggca cttttgtgcc 187020 aattgaccat aaatgtgtgg gtttatttct gggctgtcta ttctgttcca ttggtccatg 187080 tatctgtttt taggtcagta ccttgctatt tctgtcacta tagctttgcc gtatatttgg 187140 aagtcaagta gtgtgatgcc ttcaactttt ttctttttac tcaagatacc ttctgctatt 187200 tgggctcttc tgtagttcca cacaaattgt aggatttttt ttccacttct gtgaaaaatg 187260 tcattagaat tttgatagag attgcattga ccctatatat ttctattgat ttatgtcatc 187320 ttcagtttct ttcatcagtg ttttatagat ttcagtgtac agatctttca cctccttggt 187380 taaatgtatt tattgaagct attgtaagtg agattgtttt cttgatttct tttctggata 187440 gttcattgtt catgtataga actgctactg atttttgtat gttgattttt gtatactaca 187500 actttactga attaatttat tagttctaat agttttttag tgaaatctga gatcatgtcc 187560 tttgcaaaca agacaactta atttcatcca ttccaagttg gatgcttttt atttctttct 187620 cttgcctaat ttatctgact aggacttcca gtaccatact taatagaaat gtcaatcaat 187680 aatttctgtt gagttcatca cagtatctgt ataaacacaa taaacaacag gaatatgtag 187740 ttaggtggca tagttttact aggttcaaca tcataccttc taaatcgaga gcttagttag 187800 gcttttccct taagcctcag tttcccccaa gtgaaatgga attataactc tgggtttcca 187860 tgaggattag atgagaaaaa gtaaggcctt tggcataaag taaggcctta ccgctcaatg 187920 gtatctgcag ctacgttaat tcaaaaaatg aaagaaggtt ttatccagat tcagattgct 187980 tgacatccat ctaccttcat tcaaacaatc tacagctttt aaatactttt aaaaatgtgt 188040 atgctttata aagaaaagca gctttttata aatatttgtt atgaaagtgt caaaattgga 188100 acttgtgttt ataaagtatc taaagtgcac tattactgta caacaggggt ccccagcccc 188160 cgggccatgg acaagtgaca gtccgtggcc tgttaggaac tggaccacac agcaggacag 188220 ctagagatga gtggtagatg agcgaccatt actgcctgag ctctgcatct gtcagatcag 188280 tggtggcatt agattctcat aggagcgtga aacctcttgt ggactgcaca tgtaagggat 188340 ccaggttgtg tgctcctcat gagaggatct aactaatgcc caatgatctg agatgatctg 188400 aggtggaaca gtttcatcct gaaacaatcc cccacactac ccctcccccc acactctcca 188460 ccaccccgtc caagtctttc taacactggt ccctggtggc aaaaaaggtt gagggctgct 188520 tctgtatact tgtttttcaa aatatctcat gtaatcatca taaaagtctt gctaaatggt 188580 attattatca ttcccatttt caggaaggta agttaaaggc ttcaaaagtt tagatttttc 188640 ccaagaatac actgctaatg tgtagttttg aacataccag tttagattat taagtctcgg 188700 ctctttcccc catatcacaa actcaaattt cactgctttg taattttcct aattaaaatg 188760 aaaaataact atgaagtttg tgggaaacaa aacatttttc tttaatatcc tgttttacaa 188820 atttacagaa gaataaaact ttaaaaagtg gacaaagatc atgaacagac ttctcaaaag 188880 aagacatatt tgtggccaag aagaatatga aaaaaagctc aatatcactg atcattagag 188940 aaatgcaaat caaaaccaca atgagatacc atctcacacc agtcagaatg actattatta 189000 aaaagccaaa aaatagcaga tgctggtgag gatgcagaga acagggaaca cttctaccct 189060 gttggtggga gtgtaaatta actcaaccat tgtagaaagc agtatgacaa ttcctcaaag 189120 agataaaagc agaactacca cttgacccag caatcccatt actgagcata tagccagagg 189180 aatataaatc attctaccgt aaacacccat gcacacaaat gttcattgca gcactcttca 189240 caatagcaaa gacatggaat cgacacaaat tcccttcaat gacagattgg ataaagaaaa 189300 tgtagaacat atacaccatg gaatactatt cagccattaa aaaaaagatt gtgtattttg 189360 cagatggagc tggaggctat tatccttagc aaactaacac aggaacagaa agccaggtat 189420 cgtatgttct cacttataag tgggagctaa atgatgagaa ctcaggaaca caaagaaggg 189480 aacaacagac actgaggcct acttgggggt ggggtgggag gagggagagg agtggaaaag 189540 ataactattg ggtattgggc ttaatgcctg gttgatgaaa taatttgtac cagaaacccc 189600 catgacacaa atttacctat gtagcaaacc ttcacatgta ctgctgaacc taaaataaaa 189660 gttttatttt ttaaatcctg tttcaaaaat tatgcactaa gatacttctc tcttacattt 189720 tatagtatcc atatttcaga attaatcttg gacatgcata cagaacattt taccaataaa 189780 aaatggtcag tatacctttg ggcagtgtta gtccttcata agtgtttcaa aaacttagca 189840 gtcctccttt acatgaaagc atgcattttt caagacaata agtaattatt catgtttttc 189900 aatatgctat ctctgaatgc tactcatggt gtgattcttc tcagagtttt ggagggtaga 189960 gtgtggcttt agttatacgt acctacctgc tgacagagcc tcagtgagtt cacaggctct 190020 tctgtttatt tactcagtca cttactgaat attggtggaa tgcctcctac gtatcagata 190080 ttatatggga gaatgagtac aaaagcatac acaacccttg ctctggtaga gctgaacgtc 190140 tagtagggga ggcagacatc aaataaacag tcatgctgat gggatgaaaa ttggcaactg 190200 agttagtttc catgagggag aattacccag tgctgcgaga gtacctgaca ggagaattta 190260 accttttcag gaaggtcaga gatggctttg ctgaagaggt gacatttgaa cctaggcgag 190320 gaatgaataa gacttgatcc aatgaagagg aaaggaaaat ttcccttcat ggtagcagca 190380 tatgccaaaa tttcttgcta gcttctttca tacttttgta gatatcatat attgaaacat 190440 agccctcaag aatattcctg aacaactgga tcctaaatta tgtaaaagat tcgctataga 190500 attacaaatg aactaccaaa atcataagtt tttggctcat acatatcttc acacaaaaaa 190560 atcattttta actatacaat catagaaaca attatgaagc atttttattg acatatgagg 190620 taactttatt acattatttt tgaccatgga gaagtgtgga aaagctttag ccatgctgaa 190680 ttctctaaag accttccaaa ttactaccat gtgccagaaa ttattctagg cttaagtgat 190740 tctaagaaat ataagataat gcccgtgtgc tgccagccca caatcaaact aaagatctat 190800 aatagcaatg agctaaatag catgtaatat gtaaaaggtc aaactctgta gcttatttaa 190860 gtgctgtaag aacgtaaagc tggaagcaac tgtttttctt cagtctttac tgcattcctt 190920 tgctttacct aatggcccaa tatattagga atatattaac tgtcttatat gagtatcaca 190980 tgctatcaaa taacctggtg tcattacaat aatgatatat tgttattgct gcttagttgt 191040 atatatgaag gtaaatgtag ctatgtttaa ttatactcgg ttactgaccc aacaaagaga 191100 gattgaagaa ttccttttaa cttagagtaa atgttctgag ttgaaaataa cctctgaaaa 191160 ttccactttc tctctctccc tctctctctc tctggtacca gtatacaatg gcaacagatc 191220 acagaagtct ttcatgcaga aatgggagat caagacccat ttctatagga tttgttctca 191280 ggttctgcca ttgtcgtatt gagatctcat gagaaatctc taagagtcag cacacagaac 191340 aagaaaacac atgctgtact attatacaca ggcaatgtga cttatcagga gagagttaat 191400 atttaaataa cttcaaaata ataagtaaat attacaaatt cattgaatac aaaatagcac 191460 tagacagttg ttattacaga tctaaaagta aaaatcactt tcaaatgttt ggcatacttt 191520 tattctctaa caatttacca tttgtgtaga gttaagcttc tctcaaaaca aaaagtcttg 191580 tgacataatt attctgatat aatcttaagg aaatcttcag catacaaaaa aaaggttttg 191640 gtgcatgtta tttcaaaatc cattcatgca taacaaagaa catgctcttt ctctgaggtt 191700 tcctgttgaa tagattagag gaagaaaata cttaggtgaa tttatttaat aattgatagt 191760 ggaaatagag tcttaatgaa atttccatct tcctgaaaca tgaactctgt atttattact 191820 tctgttatta cctaatactg atgtatgttt aattgttcat tgtcaagaat gacatgtgaa 191880 acaatgtcct gccaaaacct ggagaatcat gtctgagcat tttatatgta gacataagta 191940 agcaaatgtg taatgagtgc ttaaaatggt tataagacat ctactggaaa cttaagagaa 192000 gtatcttccc ccacctcacg tcccaccacc cagaaaaatt taggtaagct cttaaagaag 192060 gtagcatttg aactggtctt aaatcaagag tgagcaaaat ttttttgggg gggtggtaaa 192120 ggtctagata gtaaatattt aagactctat aggccaagag acaaaatcat aaaaaaacag 192180 gtggaaacct ggatttggct ctgggccaca gtttgtcgac ccctgactta aaaagtaaga 192240 tatggattgg aaggaaaaga atattctagt ctgagaaaaa gcataagcaa aagcacagag 192300 atgtgtattc atggaatgct aacaggcaca tggagaaagt agagagagag gaaactggaa 192360 atgtattgta ggctagacca tggagagctt agcatgatgt ggttgatatg gtttggctct 192420 gcgtccccac ccaaatctca ggtgaaattg taatatccat gtgttgaagg aaggacctgg 192480 tgggaggtga ctgaatcatg ggggcggact tcccctttcc tgttctcatg atagtgagtt 192540 acttctcagg agatctggtt gtttggaagt gtgtggccct tccctctttg ctttcactct 192600 ttcctcccac catgtgaaga tgtgcttgct tcccctttgc cttccaccat gattgtaggt 192660 ttcctgatgc ctcccaacca tgcttcctgc atagcctgca gaactgtgag tcagttaaac 192720 ctcttttctt cataaattac tcagtctcag gtagttgttt atagcagtgt gagaatggac 192780 tactacagtg ttaaagttta gttaatggaa aaatactgca agtttataat aggtaattca 192840 ttagtagcat ttaccaatca cttcttatga accaatatta tgcagaattt gactccagat 192900 cctatattct aactcctatg atttacttat ctttatgaac atcattaatt caataattgt 192960 ttatttagta cccaccacag gcaaactagg gatatgacaa tacatacaac atagttctta 193020 ttcccaaggt gtttagggtt ttttggatca caaactacaa agggatatgt attagtctgt 193080 tatcacactg ctaataaaga catactcaag actgggtgat ttataataga aagaggattg 193140 attgactcag ttcaatgtgg ctggggaggc ctctcaatca tggtggaagg caaatgagga 193200 gcaaagtcac gtcttaaatg gtggcaggca agagagctcg tgttagggaa ctttcattta 193260 taaaaccatg agatctcatg agacttattt actaccacga gaacagtatg ggggaaacca 193320 ccttcgcgat tcaattatct ccacctggcc ctgcccttga catgtggggc ttattacaat 193380 tcaaggtgat atttggttgg ggacacagcc aaccatatta ggatataaac ataaagaatc 193440 tgtaaatgtg gccacacaaa tttagggatg acccccatag tttttaaaca attaatccta 193500 catactgtga aagcctcata tgtaataggg gctagctgct ttttactgta gctattaagt 193560 ataactattc ccacaaaaca cactggaaca catacacacc aacacacaaa aaaacacgtc 193620 agagccctgg ttgagttagt ttaggagact gcggcaaccc tgggcaactg taaatctctt 193680 agcagtttgg gctatgaact acttaactaa ttaacatgac acccatgcca ttaggtggac 193740 acataaacta aggttctcta tcttttcttt ttggagccag caacctcatg gccctgggaa 193800 gtccacattg aagcccctct gtatttattg gtactactga ccgactttag acaaagtctg 193860 tatgtatttg ttttctattg ctgggtaatg aattaccaca aggttatcag atcaggttaa 193920 aacaatacac atatattatc tcatagttct gtaagttaga aggctgaatg gactcagctg 193980 ggttttttgc tcaaagttca caaggctaaa atcaagatgt tacccagcct gggctctttc 194040 ctggagcctt tggagaagaa tccttttcca agcttattca ggttgttggc agcatctagt 194100 cccttgcaat tgtgtatctg atgtcccttt ttcttttttt gctgtcatct gagggctgct 194160 gtctgctcct agaaatcacc cacatttctt ctcttatggt cccctttgtc ttcaaactgg 194220 aaacagctca tcaagtcctt cttagagttt gaatctctct gttttccctt gcagccacca 194280 attagaggac gctttctgct tttgagtgct catgtcatag aataagctca ttgaataaac 194340 ttctcatctt aaggttagct atgcttagct atgccatgca acataacaca atcacaagag 194400 tggtatctca ttatatttca ggttttggag atgacagctg acatctttga gggaaggggc 194460 cgttctgtag tgtggagtgg aaacaaatgg agaatagaaa gagaaagcag taaaagaata 194520 ggtagagagg acaacatagg ttatgggctc tgaaatgcat aatataccag ataaattcat 194580 cttcctctat tacagtgtga tggatcacat tgatgtatga gaagcagatg caacagtgtt 194640 gtattttagt aaggccttac tctgtcctac gtgggcattc tcagttctaa tatatacaga 194700 taaaacataa atatatttgc aaatataaat cgcttattgg aactctcttc ttgtttttcc 194760 tggcttgaat cctcaaaaca tggtatgttt tgctgtatac actgagttga caaaactagt 194820 tcttgtataa tttgaccaca tggattgtat atcttttcaa gcccctatag atttcacggt 194880 gtttggaaac cactcattta tgcctttgta gaattagatg ggcaaataac tgtgactggc 194940 ttatcaacag ggaaaagggt gatttgtgta gatcgagaga tgtgttacat gagaagttca 195000 aattctctca ctggacagca atgtaaaaac tttcccagga aaacatacac tctctgggtg 195060 ttaccagaaa ctctcagtgt gacctcattt gggaaagagg acagagagct ggaggaaatg 195120 gatactgttg tacattctac ccatgctcaa tgcataatga aaaataatga attgacttat 195180 cctcttttgc aaaggaagtc agtctctagg aaagtagggg agaaatacac atggtttata 195240 acctaaaaaa gtctagataa agtttcccaa gatttcacaa atctgaagag caatgtcttc 195300 tttaatttta acgtttatag agatgatata cagatgataa gagttcaaca cattctaaat 195360 ttgcaaatga cctcagatca gcatggtacc tctgttccat ggtgaatttt ttgtttaaaa 195420 attacatttt gtaataggcc aggtgtagtg gctcatgcct gtaatcccag cactttggaa 195480 ggccaaagca ggtggatcac aaggtcaaaa gatggagatc atcctggcca agatagtgaa 195540 attccgtctc tactaaaagt ataaaaatta gctgggtatg gtggcacgtg cctgtagtcc 195600 cagctactca ggaggctgag gcaagagaat cacttgaacc cgggaggcgg aggttgcagt 195660 gagccaagat cacgccactg cactccagcc tggtgacaga gcaaaattct gttaaaaaaa 195720 aatgcttcaa taaatataaa ctcaaatcaa gcagaggtga aacaaagtag tgccatgggg 195780 atttttaaaa acataaatat tctcaaacat acactgattt tgctaaaaca gagcagaaaa 195840 gttgtactta ttgcagagaa acactagtta aatataagta ggcaaaatgg taatgatttt 195900 tagaaattta tatatacaca cacacatata ttgactaaat tttattgaca agatcgttat 195960 tttctaaggt caaataaccc tggttaaata ggcattctgc atattttgca gtgttagtga 196020 tttaatgaag cagtgtgtta aatatagtct tcacttgctg taaggaggtt taaaggtttt 196080 tggagaagat aaactaaaat aattaaggaa aaaaatagga cctctgagga aagcaattag 196140 tgtcattttg tttggaaaag acaaagcaaa gaggtttctt cccccaggta tgtgacacat 196200 tagtacaaaa aaagaagttt attctaaatt gtgactgctt aactaaaagt tgttattaaa 196260 atgaatggcc attatctctt actagcgaag tattgataga taaaatctta tatttgtact 196320 ttggataaat cctaatgttg gtcagatttc aaaccactga agtaccgttt tggttatatt 196380 caggacagga tggcttagct taccattttg gacagaaaga attgtagata tgttgtgata 196440 gaaactaagg gagctttttc actgataaaa ataaatagat ccaatgtata acgctactgg 196500 gtatttttct ggggtgggat cattagtcac ttttaactat tttacgtgga caactttatt 196560 aaaaaaaaaa gaaaaacttt aatgtactaa aaagacacac cactatcagt ttcttcttat 196620 ttaaatcact tcttacttgc taatttcctt tcagagaaac aggttatttg ttgatactga 196680 gtgggtcatt gtaaatagca cagatacagc gcagtctttt cctcaagtcc atttgttttt 196740 ctgaatttgc ccaaaggact tccttttacc atggacagtt gatgtggggg gcgggggtag 196800 gagggaaaag caggtaagaa agaaacatac cacagaaaag atagttaaga ggaaaagagc 196860 agtatggtgg tgactccaag cccataaact gaagaaccac ggtgtttgcc cactaaataa 196920 cgagttagaa ctttccatta taatgttccc tttatcccct gagtgtcagt cactattttt 196980 aaaggtccag acaactctta cctactaata tatcagtctg ctcaattaat catttttctt 197040 ttttcttttc ttcttttttt tttttttttt tttttttgag atagagtctt gctctgtcac 197100 caggctggag tgcagtggca tgatctcggc tcactgcaac ctccacctcc tgggttcaag 197160 cgattcacct gcctcagcct cccaagtagc tgggactaca ggtgtgcgcc gccatgcctg 197220 gctgattttt tgtatttagt agagacgggg tttcaccatg ttggccagga tggtcttgat 197280 ctcctgacct tgtgatccac cagccttggc ctcccaaagt gctggggtta caggtgtgag 197340 ccacctcgcc cggcggttaa tcatttttct ttaaacaatt aaatccactt tactttttcc 197400 ataatgtaaa tgcaatttca tttcagctat aaattttcac aaatactttt cctaatattt 197460 atactttaat ttactgtgta attagagtaa aaaatattct gagaggtttt gttttttgtt 197520 ttttgggttt ttttgtttgt ttttgctttt ttgtttgttt gtttttgcaa ataggttctg 197580 ataaattcct cagtgtgcta gctaaaaaaa aaaaatcaat agtctgaatg gtcatcacct 197640 ggggctgctc tgagccagtc tgctgccctg cttgatacaa aaagtttgga aggtgaacag 197700 cgttagcatt atttgataaa aattaccata aaacactgga agggcaattc ttagagtcat 197760 taaaatattt caaaggaaga aattctatta agtctggatt tctctaagta atagcttggg 197820 ctgtgtagtt tcaagcttta attgcataaa tatttctatt ttatctccat tgcactccat 197880 aaaatattct taaaattctc aaaccatatg cattctttca tcttacattt cccctagtgc 197940 ccataatttg accagcatgt tatgcctggt taaactgttt cagcttaaaa ttaaatacag 198000 ttggatatct gtggtgtttt ctttagcatt tgtctggtta cttagtgctt cctccagcct 198060 cctggctatc cactctccat tctacaggaa tagcaagaac acagctgcat gatgatgtgg 198120 attttgagtt aggcaagtgt cactgcagcc ctaaagcacg tctgtggctt ccaacagata 198180 tgtacaggtg tttctgctgc caggtgttct cttgctccta ggagccacca cagtgtgata 198240 taaatgaaag acgctctata acagcagaaa tggtcctcca tgaatcattc aactattgac 198300 aacaatacat ttctccaaga gcccacaatg tatgctatgc cttttcctgt ggaagtactg 198360 tgattagcta aactgagaat ctttcattta agtaactcag aaatatgtgc aatatgcctc 198420 ctgcacataa gaccttgtaa tagggtcatg gtacatacag agacaagatt cagagacaag 198480 aattaactta agggctgtac aactcatatg ttaaatttta agaaaagcat gtacaaatgc 198540 aaatttaaaa taataaatat taaatggcaa gataatgatg taaaggcagt gttttagctc 198600 agtgcctaac aaatgggata atcaatacat atttattgtt gtaattaata tactagctga 198660 gttgtgatta caaattgagt gccttaagag tccagacaga agccgtcact gtgaagtatt 198720 taattgtgca aaaatactaa ggcttgagat cctgaattta accacagcaa aaactctcgt 198780 actctatact tatctattgg aatttattgg gctgaagagt ctttagtttc atttgaaata 198840 tgtcctctga gtggccagat cgttgtcctg cttctttatg aacaaacaaa ataaaataac 198900 cattggggct ccattgaaac tgaaatggct aagaaaggcc ttccagttat taaatatatc 198960 taaattcctc agactctatg ttcatatttt taaattaagc tttttattct gggataatta 199020 taaaaaaaat gcagttgtaa gaaataatgt agagagatcc catttccacc aatgataaca 199080 ttttgcaaaa ctagtttcca ccaatgataa cattttgcaa aactagtttc caccaatgat 199140 aacattttgc aaaactatac tacaagatag cacccagaat attatcattg atgtaatcaa 199200 gatacaaaac atttccctca caactagttt gcctgtataa tcacttccca accccttcct 199260 taatccctga cctctagcct gttcttcact tctgtaattc tgtcatttca agaatgttgt 199320 gtaagaggaa taatatacta tgcaatcttt tttttttttt aaatacagag aaggtctcac 199380 tatgttgagg aggctggtct tgaactcctg acctgatctc aagggctcct cccatctcag 199440 cctcccaaag tgctgggatt ataggtgtga gccatgccac ctggcctagg aatcacatac 199500 aatgtaatct tttagtagtg gcttttttca gtcagcttaa ttttctgcat attaactcag 199560 gtttttgcat atatcagtag ttcattttat tgttgagtag tattccacga tacacatgta 199620 ccatagtttg tataactgtt catctgttga aggtaatctc tgttatttat gggttttggc 199680 tattataaat agagatacca taaacattca tgtacaggtt ttacatgagc ataagttcca 199740 ggactgtaat tgttaggtca tgtggtagtt ctgcgttgag tttttataga aattgtcaaa 199800 ctgatttcca taatggctgt atcattatac cttcccatca gctatgtctg aatgatctag 199860 tttttctaac ccccaccagc atttggtttt atcaatattt tttagtttag ccattttgac 199920 agatgtatgg tgatatctca ttttggtttt aatttgtact tccctaatgg ctaatgaggt 199980 ggaacttttt tcatgtgatt atttgccatc tgaatatagt tttcagtgaa aatctcttca 200040 tgacttttat ctattttcta gttgggttgt ttgtttcttt cactagtgag ctttgagagg 200100 tctttacata ttctagatac cagtccttta ctgggtatgt cattgcgaat attttctccc 200160 acactatatc ttgtcctttt tgcagtaaaa agttttgata ttaacaaaat ccaaattgtc 200220 aatttttcct tccacgtatc atcttttggg tgtcaagtct aagaattatt gcctattcta 200280 gatcctgaag attttcttcc atgtttggtt ctaaaagttt tgtagatgta cattttacat 200340 ttaagcctgt gatacatttt gagttagttt ttgcacaagg tttgagactt gggtcaaatt 200400 tcattttttt ttaatgtata tgggatgtcc aattgctccc acttcatttg gtgaaaaagg 200460 tatccttctt ccactgaatc atttttataa cttaaaaaaa ataggcaggc atatttatgt 200520 gggtctattt ctaggtactg tgttatattc catggatcta tgcatctatg cttccactaa 200580 taacatgcaa tcttgattag ggtagctatg ttataagtct tgaaatcata taggctaatt 200640 acttccattt taatctcttt caaattgctc taaaactatt ctacttcctt tgcttttcaa 200700 tataaaaatt catgcaatat tgtctatgtc tacataaaaa atattttgct gggatcttga 200760 taagaattgt gttaaaccgg tatagcaatt tggggagaat tgaaatagtt actattgagt 200820 cttccaatcc atgaacacac tttgtcacta catttattta aatatttgat tttttaaaat 200880 cagcatcgtg tagtttctgg cacagaggtg ctatacattt ttgttagatt gacacctaag 200940 taatcttggt agtgattgga aatggtgtta catttttaat tttggctcat ggttagtata 201000 tagaaatata atggggcttt tgtatatgtc tcctgtgccc ttactgaact catttattag 201060 ttcaggaggg attttcggca gattccttag gatttttgtg tgccatcaat catgtgtact 201120 acaaatagga acagttttat ttcatccttt ccaatccgga tgcttgtgct tccttttctt 201180 gccttattac actagaattt ctagcactgt gttcaataag agttgtgaga ttggacattt 201240 ttaccttgtt cctagtctta gggggaagac attcaatctt tcagactctc tgatattgta 201300 attttgtcat tatggttagc ttttatgtca gctattttaa tgctttttta aatttccata 201360 acaggccagg taaagactat actgaaaaac cttctaatgt gctacttgta tgcatgagct 201420 ttggggttag tcaggactag ctatgattcc tcactcgatc catttctagt agtgttacct 201480 tgggcaagtt tcttaaactc tctaagtctc agtttcttca tctgcaaaat ggtacaatgc 201540 attcattcat tcatccaata aatgtaaatg taatattttt aaagaattga taataaaagt 201600 gcctacctat ctcacacaac tgtgaggatt gaatgagata atgctagtaa aatgattagc 201660 acaaggtaat aatttaaatt ttagctatca tcactgttag tgttagataa aatagtgtcg 201720 aatgaaagat tctcctgtaa gaatgtattt agttgttctc aactgggatg aaaagagtga 201780 tctttctgca acaccaaggg atgtttgtta atgtctggag atatttttgg ttgccacggc 201840 tggtggtagg gggaagtgtg ctattagtat ctaataggca gaggccaagg attgtgctag 201900 gcatcctaca atgcacaaga cagcatcccc gataacaaag aattatgagt aaggttcaaa 201960 tgataatagt gccaagtttg gcaaacctga tttatatgga tagatgtctg tgcgtgaata 202020 tgttaaaaat agcttgcagt tcaccagtga atttccattt cccgtttaat gcttggacta 202080 aacctacttt ctctaggccc tcttatcgat tggtctcccc cagtttagaa ctgcccttag 202140 tctggtatgc tttcaattat ttattaattt atgcttaatg atctgagttg ggtcaccagc 202200 cagagagtaa atgtttgcac acagaaattt catattcctt ggaaataact aactccattt 202260 ttctagtaca tattgctgat agtcatcaaa tacatttaat cacgcttctt tcgactttga 202320 ttttttgatc ttagatgctg gttacttttt aagctcttgc tctttattac tatttcatca 202380 accgttcaga gttaatgatg tgacatgttg tttatcagta aggttcagta acagtgctag 202440 aaattttctc ttctgctttc aaaatgcaga aatttaattt gttgtaaccc taagccatta 202500 atattttctg ttaaaagtac tccaaacagc aatgcatata aaatgacctc atattgatat 202560 tcaaatcaac atttgaaaaa ctgacttaaa aaatcagtat aaaaaatgca actgatgatt 202620 aagtaaaaat cctttcccaa gggcaccaat ataaggcaga atctaatttt atgtgcctcc 202680 agtgactgtt ttgtcttctc gtgagttttg tcattgacca taagcacttt tatagcacaa 202740 tccttggtat tcgaaggtaa agctagaaat gtccaaggag tacctccaga tcacgttgca 202800 actatcacct caatgtcaaa aacaatctag ccaagaactt tatcctcaag tattatatta 202860 tagctagagt gtgcttccca ttgaacgata aaatgtgagg ggtgcatcct atttaaaaaa 202920 tgctcctcca taggcttgcc attgattctg aattccctca atcatggtaa cccctttgaa 202980 ttaaaatgtc atttctcaca tgatactatc aaaagataat tcaaacacaa gcactaagag 203040 atgtaacaca ctacaacttt tcatcaactt acatgtaaac cagcatgtta atgtctggat 203100 ctgaaggagc taataaatca caacaatctc ttctctgtct tcccaagatc agatagagat 203160 cagcacatca attttctttg ttttgttttt ttaatcaaaa ttgtatatat ttatgatgta 203220 caacatgata ttttgatata cgtctacatc atggaatgac taaatcaagc taattatcaa 203280 aagtgttacc tcatatactt gttttattgt gagaacactt aaaatctact ctcagcatta 203340 ttaagtatac agtatgttgt ttctaactat tgtcaccatg atgtacgata cagctcctaa 203400 actcatttct tctttctaag tgaaatgttt tatcctttga ctaatatatc agttgatagc 203460 atatgagctt tctaattagt taaatggatt agagaacaag gcttagatgt ttggccactt 203520 ggaactatcg ggtatgtttc ttccactaat gcaagatgat ccaggggata gtctgccaag 203580 cagacaccta catggaaagt tgcaagggga atcactgcct tactccacag gccctggcaa 203640 aggaaagaag aacaggtcac atagggaagg attaaatgat atggaaagag actagaaatg 203700 tggaaattct ccacatgaaa acaagaggat ggaattcccc taaccattaa catggaaaat 203760 ggcactatca actttcagag atgagaaaaa gaggtgcaag aaggcacatt ttgatgtagg 203820 caaagtcatg ggggattgtg aggagtaaag aagaaagaaa aatccaatat tgaattttct 203880 tgattgagcc tctaatgaat tcctttaagg ggactcctat aagattccat agtttgaaag 203940 aatggtgggg agggtggtgg caagcagcca agtgtcccta gattaagtga agaaacagat 204000 tgaataactg caaagtgttg acagtaaaac tgtaaatgac aaagcaagat ctattactca 204060 gtaaaatgta tcaggctagc cttgcagagc aacattcata acttgggcca ttgaaggaaa 204120 atagaataaa tagctttgtt ttctaccctg aagggattta taggttaatc ctgtgatgtt 204180 atttgcttcc atccatgtta atgaaatata ttgcttccat ttgtgtgaaa aaatacctaa 204240 aagcaacaga atatgatcag tttattaaaa tgtgcacttg tgatgtgaca tgaagtatgt 204300 gatgactatg tcatgtcaat gaacttttat gttcagtttt tggtttggaa ttaaaatgct 204360 tatgctttga atcatccagg cctggcaaca aaaaagaaaa ttttatctag acagtgaaaa 204420 aataagagca taagaaacta gccaaggctg attttgcatg gattaggaaa cacgatgaga 204480 gtccaacagc tagcaggaag cagtaatcga cacgacattg gctctctggt tgacagcact 204540 tggcaacaga tacaatgact gtcttacaaa cagaatgatc caggtaaatg ctgggcaaca 204600 ttcaaaaaca aatcttttct cagaagaaga tgaatgtttt agatacatat aataatttct 204660 tcttttccgt ttctaccttt ggctgagatt ctaatttacc ctgatttgat agtgctaatt 204720 ttaggctgtc ttcatgaaat aataccaccc cacaaaatct tgttgccaaa tggaaaaaaa 204780 atgtgctaaa taaatacttc atttgaacat caatttggaa gggatacatt ttatgcatag 204840 atactaaaat acctgaaacc aaagtaggtg tcaaaaagga agctctaatg aaatggacat 204900 gggctcttcc aagagaggta aagtgagctt ttgatgtatt tcgtaaagtg agaaaaagaa 204960 ttattcgtaa gagagagccc actaaggagg catatttgat agctttttct ggcagcaaga 205020 tgtttccaaa aatccctctg gcttgtggat gaaaactcat agggaatttg agctttcttg 205080 tgtgagaaaa caacagggtt ttcagcagct tctcataagt taaaaatttc aaatgtttaa 205140 tagcaaagaa ctgcactctc gctgaaaatt ttgtcagtgg tcattttgca caagataaaa 205200 tggagaaaca ttctaagtca agattttgtc tttttcatta ggcaacaaag acaaagaaga 205260 ggtgaataga tcacaaccaa catagttact attcaaaaag aattagcagg aattgtgatt 205320 cagatatgtg catggcagca attttaggcc tgtgtgggtg ggtgtaaaat cagcactgag 205380 atttgcaaaa ctttaaagcc aaaaatctgg actaaacaca tagattcttg aggcaataga 205440 taattcagag caccccagat caatctggaa taagcaatga ttacacattc tgaaataggc 205500 aacagttcta tagggaaaga gaccagaaaa agtatagtaa tatcttgggg acctattatt 205560 attataatta tttattatta ttcccaagaa tggcaacttc atttcatttc tctgccactg 205620 gattttgaaa aacttaagga gacaaactgt gtcttaccta ttttatatcc caatgtctag 205680 ctcatatcct ggcatacatt aaatatttgc tgagaattga aattataaag caactgcaga 205740 ttatgacctc tgggtcagat atgctaaatc agcactgtcc aatagaaatt tctggaatga 205800 taaaactttt ttacactgtc caatatggta actactagcc acatgtatct attaagcagt 205860 tgaaacatga ctggtataac agaagaactg cattattaat tttatttaat ttgaattaag 205920 taaaatgtaa aattaagaat taagtagcca catgttagac agtgtggtgc tatattttac 205980 aaaagaataa agagaacgga aggtgttggt tttctgacta ttttaatatt ttttgactat 206040 tgtctagcta ccctcccaat ttgtcatctt tcatcaagaa acccaaagta aagaaaaata 206100 gtcttatatt tcaagttagt gaacagtgac aggtcttttt cttattgact ttcattgact 206160 ttcttttgct tcctattccc tcctataatc tttgactctg tctatagcca agcataatgg 206220 aagaatacta agcacacaga cctgctggac ttgcactgga accgcggaga cattccttaa 206280 ggccctgggt ctcagtcccc tcatcggtga catagagatt acaatgctca cctgataggt 206340 tggcaggagg attaatggca atattcttag ttcctgctgc aacacttaca cataaaaggc 206400 agtaaattgt agctgatact actgtagttg ttgctaggat aagataatat gctaattgct 206460 gtgaagatat tgaaagatat agttaagtac caatattttt tctgcccttt gtcaatatgt 206520 cccttgtcaa tacgtcatcc tagctgctga tataaagacg gcatgccctt ctaccaggac 206580 ctgcgtgctt tcaaggtctc tgtgttacct atacaaagaa agagaaccct gtgttaccta 206640 tattttcata atcctagcac agagactggt atttaatagt atttaatact gctttaaaat 206700 gattattgaa tttaaatgat ataaaaatat agtatttact gctgctgcta aaggaaaaca 206760 atgtccttat agtacacagc gatgagtaac agctatgagt agaagatatg atgaacagaa 206820 aacatcccat taactatagt aacattaatt tcccacacaa ctcattcgtt acacacacag 206880 ataaatacat attctaggaa aatgtttaac aataaatggt aaggatctat gtaaagaaaa 206940 ttgtcaaact tatataagtt attcaatatg tacaaagatt tcagttaatg caaaggcatg 207000 ccttagtcct ggatgaaaaa attcaatgct ggagagaagg gtaattattt tgaatggcct 207060 gtggagaatt tctaggaaat ttttgaaaaa taagaataaa aagattgccc tatcaagtat 207120 taaagcaaat tacaaagctg aaatgagtaa acaaatgtaa tgtaggtacg agaatagaca 207180 cataatatgt ggaataaaat ggatgcattc aaaatggccc ctagtaaaat aagttaacat 207240 agaaaaaggg tcacctgcaa aaaatcagtt taccatttct atttgggctg tattccaaaa 207300 ataaattcta gatggattaa gggtttatat aaaatgacac caagaaataa gatgaaaata 207360 ttatctgatg ggtgtaggga aagcataata aactttaaag aaagtaaata acatagataa 207420 caactaacag ttatacatct acacaatctt tcagtgtttt atcatcatta acgtatgaac 207480 aaaattaaat tatacaccat aaactgtgaa aaaagatttc ataagcacaa agaaagggaa 207540 attcctagag tactgcagtt aggaattctt taccttggtt taaatggtgg ctgaggcaca 207600 tgtaactata caaccttagc ctgattattt cggccaagtt tatttttctt atctttaaaa 207660 ggaaaatttg aaataatata taccttacag gtttaacaag acaaatgtga aaatgtataa 207720 aacccccgtg tgttacctaa aacatagtaa attaataaat gatacgatag gctaaaaaca 207780 aaaaggagtt aagatcctag ttatatagct ttatgaattg taaatattaa tattaatttc 207840 tttttgatct gaaacttgca aatacttttc caaggcagtt actttctgtg acctttattt 207900 ctcttgtatt ttggaaaagt ctttcatttt tatttagcca aatctaccaa attttttcct 207960 cccacttctg ggtcttgcat tttatttaga aagtctttcc ctcctttaca actttctcca 208020 tctgattata aaaacattct cctgtatttt tatctaatat ttgaattttc aattcatata 208080 aaatttattt gttagtacag agcactatat atgatctaat tttgtttcat tttagatggt 208140 tagctgattg tcacaagacc atttaatagt ctatcccttc ttcaggtttt taaataaagc 208200 ttattcaaca tatatttata tgtatttata ggtctttttc tggaatcaat tcttttccat 208260 tgatcgatta tggaatcctc agccaacctc cctgttataa ttacaataga ttaatatttt 208320 gatctctttt tagacaccgt tctttattga aagtttcttt ctaatattga atattttctt 208380 tttcataatg aattgtaaaa tcaacttatc aggttctata aatataatgt tgagagtttg 208440 ataaaaaata ttttcagttt atagattatt tcaagggaaa ttgatatcct atgaaactga 208500 gatttttaaa tcctaaaatt tgatatactt ctataattat tgagttattt tcagcaccac 208560 acaatcagtt aaacttgcag ctttctccat ctaggcatac accttccttt ataatttcat 208620 tctcaagtat tttatgctgt gttgttgttg ctattaccaa tgatactatt tttccattaa 208680 attttctaat tgggtattcc tgctttacgg aaaagctgtt gaatttgtta aacttaccat 208740 cttgctgaat cattttatgt ctttcagtag ttttcagttg attaatgtgg atttgcctat 208800 tatataacct tatctccaaa tacgggcagc ttttttcctt cctctccaac atttatacat 208860 tcattttttt atcttccttt ttctataaat gaataagacc tacatatgat gttctctagt 208920 agttttttcc cttacatttg gtagcaggac tgtttctaat atttaaccat taggaatgat 208980 tcttttcggc gtgggtttct ggtagataat cttcattaaa tttttggagt taattcataa 209040 cactttaaaa cagaatttct tgccgagctt taatatttct tgtgtcaaac tacatttaca 209100 ttcttcttaa tcctctgtta gtttctctac tctccctgac ttcaaattct tccttctcaa 209160 taagctatca atttctttct gtgattcatt atcatctggt gttgtttctc acagttactt 209220 tttaattttt ttctatgatg tttcagatac tttttgagtg ttataactat atttaccaac 209280 tcagataaaa tggaataaac ttacattatt ctatgatttt agcaataacc tttttcttca 209340 cagatttttc tgtaattcaa tattttaaac aaaatcttat aagttaaaat taagaaataa 209400 tagtgtatga atttatttca actttactct taagagttaa atacagaatc tgtccattga 209460 taagaaacag ttcagataca tttttttcct ccaaattttt accatgtctt aaccacccct 209520 gttacacaca atcatcacag ggagatctgc tctaatcaaa aaatacccag agacacaggg 209580 aaaaaatgca atttgcctca atgtacagaa acaaaaatgt aaaatgtaaa tgtaaagagt 209640 cagtaataga gtggtattcc cagtaggggt acagggcaag catctcatct ggtgaaagtg 209700 cagcagaacc ctgttacaac acagtaagtg gcagcctaca aaattcaatt gcctaaaatg 209760 cagttattgc agataaatga aataccagga caaacctgct cagcttgcaa gcctggtgtt 209820 cttgaaatcc agctatgaaa tctcactctg cccaggtcca gctgcagttg acactaacct 209880 agtagtggtc tttcactctg ggtttaatat gaatggtggt ggttctaggg cctgtgacag 209940 atagggaacc tcagaaccac agcagccatg ccaggactct cccagctacc tggaacctga 210000 tcggggagat tagactggca gaacaccaag acagagttgc ttatatgttc ccaactttta 210060 ccctctccca ttaagattaa aactttagcc cacctccatc cttaatggga gaccttattt 210120 tttaaaggtt attttctcac gggtgctatt ttccctggct gacccaacct ttagacctgc 210180 ttagagtata tttaatgcac tacattaata ttgctaatct gtgtttaatc actgctttta 210240 ctttgaacaa catctattaa tattctcaaa aaggatactt ggtactcagt gtttttattg 210300 tctaatttta aaccactgcc tgaaacaact atctttttag gaagaaagaa atcctaattg 210360 ctaaagccag tgtcttcacc tgtagctgta atgacattac atttttttca cttttcttgc 210420 gtcttttttt tccatgtctt tttttaatgt tagtttttat tcctcttctt cccgcatcta 210480 ttggttgtag atgttcctga aggtcttgtc cttagtgtac ttctcccatc taactccata 210540 tcttttccta gataatctca tctagcttca tattttcatg tcataacaat gggtgtaatt 210600 cccagaattg cattttgaac ctttatgctc ctctaagctc tagatccaca gatcctatgg 210660 ctattgttta tctatttgta ggactttgtg gagaattcaa attcaatatt tgcaaaactt 210720 aactcagttt tacatatatc tgagttttta atcaccttga gttattttca tgcctatggg 210780 atgacctttc caggccctaa gtcttgtagt ttcttgattg ccttaattcc atggagcttc 210840 atatccattt catttaggta agttattcca tgatcaatat tcggatgttg tcatcacctg 210900 gacattttct gcctctgaaa actgaaatat aaattactta tttcagtcag taaaatcaac 210960 tcaatccaaa tttcttcatt tatgtccaat tataatgtaa tcttttgggg gtaaatctaa 211020 attctagtat tgttatatct gtcactatta gtaattcaat gttctgtctc taaagattca 211080 cttcaaacag tgttgtgatg gtaaacattt gataatcagc tcacagaaga gaaaacccct 211140 gatctatagc atttgctcat ttctggagtg taaatactca taccatggcc aatttcaagc 211200 tactaacatg acgtcactga atgtggtatt gggaaaaact ctgcactatt ggctttggag 211260 agcttgtgtg agcaaaggtg actccagcac catcaccatt catattaaac ccagagtaaa 211320 agaccactac taggttagtg tcaactgctg ctggacctgg gcagagtgag gtttcttagc 211380 tgaacttgaa gaacactagg ctggcaagct gagccagttt gtcctggtat tttatttatc 211440 tccaacaatt gtattttagc ccacttcatt gcatctacac ttccttttcc tctatatcct 211500 gcctcatgac agattctaaa ccccatcagg ccctacattt acatttcctc tgacagcgat 211560 ggtgggggaa gaaatggcaa tgggaatggt gggggaagta atggccagga aaggaagctg 211620 ctggctctgt tacgcaattc tctgagtttc aactaaaatg cctcaatcat agtctgctat 211680 gccagtgatc caatggaagc ataactactt gggaccactc accacggcca tacatgaggg 211740 tatttccctt attcagcagc ccactagtga ggtaagaaag tcagcgttgg cctgtgtggg 211800 agacttctat ttccaccaca tcaccacaca gttcctggct ttacagaaaa cttgtgtgta 211860 tgtggtgatg gtgtgggtgg gggtggcatt gattgattct ggccttgtcc caatcctcta 211920 tgctatactg ccatattcct actgccctta tgccttgccc caagagtgat gataatccta 211980 tgtgttctgt cattcatgaa cttgaggtcc aaaatgtata ctggtcctca tgttcagaaa 212040 aaactacaat ctgctgtgag agatgagtct ctctagcaat aaagtggcac acatacaccg 212100 tggaatacta gccagccatt aaaaatataa acaagatctt gtactttgca gggacatagg 212160 tgaagctgga ggccattatc cttagcaaac tgacacagca acaacaacaa aaaaaacaaa 212220 tactgcatgt tcttacgtat aagtgggagc taaatgatga gaccacatgg gcacatagag 212280 gggaacaaca cacacggggg cctattgaag gacagaaaat gggatgaagg agaggatcag 212340 gaaaaataat taatggttac taggcttaat acctgcgtga tgaaatagtc tgtactacaa 212400 accctgatga cacaagttta cctatgtaac aaacccgctt atgtacccct gagtaaaagt 212460 taaaaaagaa aagatttctc aaggagagaa gatgagcatt cctcacccca catagagaga 212520 cagtgtggaa aggatggggt aaggcatcag aaactaaggc atcacaaaac ctctttggcc 212580 tgaagacctt tgcttgtgtc tggttaatac taatttcttc ctggagcaag gagaggatga 212640 aatttccttg ttctatggat cagtaaatct aatttccttt ttccatgtgt tcattttagg 212700 gcatatttca aagtaggaga agaattatct ttctccagta ccatgctatt ttaaaaacct 212760 tcatttacaa tgcaatttat gccagttgaa agaaaacaat gtattttcct cttaatacca 212820 atactctcat gaaaagattc tatctagata aatagataca cacatattcc tctactatac 212880 ttccaagtgt tcttggtttt gtaaaaacta taattcgtca ttctttattt ttattcaatt 212940 ttatgttttc agtaggggca acaaagacaa aactttctta aattttatag tcaataattc 213000 tgtccttctt ctgactagca acttctaggt gcacactcag cacaggtcac tgcaaatact 213060 attaggctaa aggaaaaata aagatatagt ttccttctta aagattttaa tcactagaaa 213120 aatttgaatg ttgactatgt caatcattca attaggcaag tctgtcctgg caatcaatgt 213180 agtgacagat gtcatggcca gattactcca gggtccaagc caaccactga gccaccacaa 213240 gttcctgagt gattccaagt caaatgtatt aaagttttca ttgtataagt catgaaatat 213300 gaaaatcaat catagtctca tagccttcag tttttacttc attcaagaat atttagccat 213360 ggattttaaa taattcctat tgactgtgaa ctatgtgtta tcttagtatt tattatgcat 213420 aagcaaatta aaattttcag ttacctctaa tgttttgcct gaatgcatgt ttaggaacat 213480 attttattta agaaaataca tattaatttt gcttcagtgt ccatggattc aattttttca 213540 tatatttaac tatggcattg ataagttaat gttcacctgg gtcagagatg ctattttcac 213600 aatctcaacc tctttgttat tccagttata atacagacag atggggaatt cagtggccaa 213660 tcacagactt ctccaatagc tgctgctatc tgaatctgga agccctaagt aaatctagca 213720 tgcagtgcac tcttgatgtt cttagatgct ggagacattg aattccccag tgctgaatgc 213780 ctctagcaaa atgtgagagg atacacttca gtttccccac agatgtaatc cacatggctg 213840 aaaagcctat cttaagacta caagggaatt cactcactaa ttaacaaata gttttattgg 213900 agtgcattct ataagcatga tcttacaaat tgccacgatg tagaaactca gtgacaacat 213960 gtttttaaaa ttcttatctt tgattggtac cacagtgtaa gaaagacaac tcactcctgg 214020 ggttttggag aaataattca gcagaataat tgaagttcca tcagcttagt taccctctat 214080 ttcctataat gataatcgtc cttttaacta attaccttta atgtatacac cttgtggtta 214140 tacaggctca gttattaatt ttcatgcttt aaaaaccctg tgttacctag gtatttaata 214200 attctcccat aatgaatata gttgatcttc tctatgcagt gatagcacct attcctaatg 214260 ccaatgctgc tagcctacaa ttcggataaa ttggctcaga ttttatgact gaatttgttt 214320 tgttacagcg tccaatactc atcaaacttt ttaaaaatta ccatatatca gacatggcag 214380 tcatttattt ttgcaggtaa aataaacttt gtatcttcaa tcacaggaaa taaatcagtg 214440 tacttcatga cttccagaat tccagttttc tctcatgtta aacttcctct tttctaccaa 214500 gtagcagtat cttccatttt caaaaatttg ttttatgatt atttctagta ttggatttat 214560 tttatgagat tttcaacatg acttaaaatg gttataagat gttgtgttta cataaggcct 214620 tcatcatcca aatatgccag ctttcagtag gtattctgtg tctaaatatt tattgtctta 214680 attaacaaat cgcctgtttg ctgacatttt tctcagttgt ttttcctaca gttagtgttt 214740 tgtatttgag agtgcaactg aaactgcata ccataaaaat agtacatatt tattgaaaat 214800 tgagctaaac aattacatat taatataaat aaaatttccc cacatctaca gtactccacg 214860 atctatagta actatagcca aagttgaacc ataatttaac tagctgcccc taagtcctag 214920 ctctgtggca atatcacatt gaggtgaatt ccatttgatg gacataatta tgtaattttt 214980 tttacatttt caaatacgta ctaggattcc caaagcaaga cttcttagaa gtctctttcc 215040 cccaggtgac caaagactct cttctgtcac ctcacacaca tctcaatcta tatcttttca 215100 tttcactcct cccgtaattt tcttaattat ttcctgttat tatagcttct acctttccaa 215160 tgtaaattat acaatgtaat ccccaacgct gcggctcttt ctacccatta tcctacctgc 215220 ataacaaata ctagaaagct aggcaacaaa accctgtgag gtgaggtgga gttgtgaaga 215280 ctcttatatt gatatttttc tttgtgctta cccaattcta tttttaaatc ttgcaataac 215340 tacaaagcat ccttttcttt aaaatggggt cttgctgcct gggccctgat gctgcctaaa 215400 gcagctgtac ccctaaaatg cttcctcccc tgctagtctg ttcaccccct actagctcct 215460 acttacctca agtaagaaaa taataacagg aaacatgtgt tgaagactga tcacatactg 215520 ggtaaagtcc taagtgcttt gcctgcatta actcaatatt cacaataact ctgtgaggcc 215580 agggctttcc ttttccttct tttatagatt aaaaagtaga agccccaagg ggttaagtat 215640 attgccccag ctcataggat ggtgtaagta acagagccat gatttgaact tagagattta 215700 gagttaagag tgcactttga cttggcatgg tggctcatgc ctgtaacccc agcactttgg 215760 gaagccgagg caggtggata acttgaggtc gggagttcgg gaccaacctg accaacatgg 215820 aaatacccca tctctactaa aaataccaaa ttagccaggt gtgttggtgc atgcctgtaa 215880 tcccagctac tcaggaggct gaggcaggag aattccttga acctcggagg tggaggtgga 215940 ggtgagccta gatcatagca ttgccctcct gcttgggcaa caagagcgaa actccatctc 216000 aaaaaaaaaa aaaaaaaaaa aaaaccaaga gtgcacgttt aaccaccatg ctccttgaaa 216060 ccacctgaaa ctccctttgg tggcgtaata tgaatcattg ctcagctgcc aatggaatta 216120 gaggttagag gttaggagac agctttatat attggtaaag gagataactg ggctatcatg 216180 taaggagtta ctaaaaatga ttaaagtttc tcattctgga aagatgtata tgatagcagc 216240 ccataaaatc gcagatgata tagctaaaat gagtaaggac gtgtctatta cattttggaa 216300 tactaatttg aatagaactt tggaaattta cataggtgag agtgtataat aaaagaaggg 216360 cattgtctgg tggttaatga cagcagacca ggtttacacc atgcatttct aggcactatt 216420 gtttgccatt tttcagatgg gaaaaggatt tcaatgggtt aagaattcaa atcttagctt 216480 ttctgatcag cccttcctcc taatccatgt tatacagtag tatcctctta tccatagggg 216540 atacaatcca agacttttag tggatgcatg aaactgtgga taggcctgaa caccatctat 216600 actgtttttc cccttcctct tgtgatgata tgtgatgata aaatggttac ccatgagatg 216660 aagtgaggtg aatgatgtag gcattgtgac ttagtgttag gctactattg ttctgaagat 216720 aggttaggag gatgatcacc tgcttcaggt gatcctgggt cattgagtca tgatgatatt 216780 gctggttgac tgtcaggagc agaccatgtc cctgactaat ggaggaggtg ggcaggcagt 216840 gtatagagtt tgtatacact ggacaaaagg atgactcaca tttggggcaa gacagagcag 216900 gatggcatga gatattgtct tgctaaccag aatggtgtac agtttaaaac gttttaattg 216960 attatttctg attctttcca tttaacattt tcagagtgcg gttaactgca ggtaataaac 217020 tgaggaaaac aaaactgcaa ataaggcagg gggactactg tactacctct caaacactcc 217080 tcaaattatt gagtcaaaag ataatgatat tagctaagat atatcatgtg taccaggcgc 217140 attcactgct caaagaattt tacaaaggtt agctcatttc atattcatca caggtacgta 217200 aggtagtatt gttcccattt tacagggaac tgagatatag aaaggttacg taacttgtac 217260 aaggtgacat aattcattca cataggtggg ctttgaactc aagcagcata gccctagaat 217320 cctgctctaa atctctgcac taaaacacct taagaggaac tttaattaca tcggtgtttt 217380 tcagtgtgtg tccatgatat taatagaccc catataaaaa gcagttctac agtcaaatga 217440 gtttattttt gttgaattat aaaattcttt tataagaaaa tgtgtaatat aaatcttagc 217500 caaagtataa attattactg ttaggtgaaa ccatatgaaa ttactaatac taagccactt 217560 tacacttaca aaaatgacaa caaaaggcaa gttacaatat gtagtatctc taggcaaaca 217620 gttttttgaa atataaacat tttagaaatg cttaaagctg ttagtgactg acaaatattt 217680 gcttctaagg aaacccagag gtacaggaag aagatatctt caacttttct agattaatgt 217740 tatggaaaat caccaggccc tagtagaatc actgcttttg aaaaacagaa ttcagataat 217800 ccataaaatt ctcaaaacca ccttgtgact gtttttgagc ataaaatctg tctaaattct 217860 acccatctca accatgaata atgtaggaat gtttctgaaa taaaaattta cttccttttt 217920 tctatctttg ggctaattgg gttcatagaa tagaaatatg aaatatttca tactgcctct 217980 ttgttttaca gaatagaaat ctgtagaaaa acaaccacaa aaattcatga aacaggatgc 218040 atgagaggca aagccaatac tcatagcaca aatttcatga cagtacctct tatttatttc 218100 ctagtcacat cccctaatag ttttttattc ttcggacatt tgtaatcagg actttttatt 218160 ctaaggagat ttactaccag gttttacgac cagttgcaac tggcctctta gtggcacata 218220 cataaatata aattagaaaa tttatcattg catttcacga ctctaggtat taagagacac 218280 aagtttggac ctagaagaaa attcagagat caattcattc tttcacccca tccccaataa 218340 aggacaaaat tgaaaccaag ggaagtactg ccaagtatcc tttggcatgt ggctacttaa 218400 ctataactat tctgtgttaa gaggaaacta atttaaatcc atttgaccac tgccagcctt 218460 gaaggaccta tttagtgata cttgctattt acttctaata aaaaaagaac aaaatagtta 218520 tgttagaccc aaagaaacca ttctgttctg tacatcccat tgtgatcagg tggctaatat 218580 ccttttcctt ttccctcact gctcgcaaaa gcgaagcctc catatcatca tatgaaggga 218640 tggtactgac ccagttttga tactctctcc catgatgttt tatgtgaatg ccgagctgat 218700 cattttcatc agcaaggcac agctcctctg ggcagcacac acaggagtat tgtatatttg 218760 ataactatgc ataagaatgg cagttaattc tttaggagtt taatttaagc ctttctgcag 218820 tttctaaaag taagtaggag aatgaataga acagaatgtt ctcattttgc agaaatagaa 218880 tagcaaacta tatatcaaga gagaaattag actgaatatt ctttaaaaag acacatgaga 218940 agtggcaaaa ggaaactacc ctttaataga aattttatct tttgttattt tggttaattt 219000 tctcataaaa gaaatatttg tactacacat gcaactaatg atgatacaga gaatcatgca 219060 aacagatcat taacaaatgt aaataaataa acctgtttca attttgctaa aacaaaagtc 219120 aatggttact ttgtatagtg aacaattttc catgtaaaac aaggtgttat ataaaaagtt 219180 cagcctctgg agaaatataa ccagccaata acacttaatc tttttgcttt ttctatacat 219240 atacacactg gcacagagta agtactgaat atatacttac tgaatttatt taaagcctgt 219300 gacttaaata tatatgcaca taataattct acgtggtttt attcacccac tcagcaagtg 219360 gtacataatc aattgtcaag aaaaatggat gaagcgtaaa ttattttcaa aaccccagag 219420 aagtacttat aggattacaa tatctgttaa aaggttccag ccctctttct cttccccatg 219480 ttggaacaca gggagtgaca atgttgagtg tggcagagaa aaggagtgtt cctcagttga 219540 gaagcaagtc attgtgttgt ggctcctcat ttgccggcag gggcatgttt tcagtaattc 219600 ccatgccata ggtcactttt acatattctc ttttttaaaa aaaaaaaaga aataaaaaaa 219660 agatgatgat acccagattg tgaagcagag gaaaaacaaa caaaaaaaaa tcacaaaata 219720 aaattaaaga attgccttat agaagccaca atgtttaaaa ttagtaatat cctgtgtata 219780 gacaactaag aaaattgctt aaccaaatga atatatacac acaccataag aaggtgtgaa 219840 atgaaagaga gaatgggaca aggtaatttg atggaggcat ttggaagtca gggaaagagg 219900 tttgggttat ttatgtttac agtgaccata tgtcccgatt tactggggca gtcccagctt 219960 atgcctttca tcccagcata ataacagaat tcctgtttct caaatgtgtc ccagttcgga 220020 taatctgtca tacttatgct aggtattaga gatttcctgc attattgagc aaaggaatta 220080 tgtgacagag gatctgtaat aggaagatta ttctatgatt tcttggcacc taaaaaaaga 220140 tgcaagaaaa attgtaagga ggctttgcca tttctatcta cctgaactga ctgttatttg 220200 gtgatcagaa gacaaataat gaggagaatc tgtgagaccc cataaaaaag ataattggca 220260 gaatttaaaa atgatttaca ataaaatatg atggatgaaa gatttcaaaa ctatgtagat 220320 ctaagttgta aatttgaggg gcttggggaa atgacattgt caataacagg gatgaaatgt 220380 tggaagaaga cttttaaaga gaccatgatc taaaatattg ctttcagggg tcaaaaaagg 220440 caatctaatg aagttatgac atgctccaat gcccaagaaa taaaggtcta aagaaacaga 220500 aaatacactg ttggaatcac cagcatatag gtgattttgc atggttctta caatttctgg 220560 gccaagatga catttgaatc tctaaaaggg acctttgaga tcatggggtt caacacctta 220620 actatagaat tttatataca tacatatata tatgaaaaat ttctctctat attaagagat 220680 tttcctctct ctatatatat tttaatatat aaaataaaag gatacataac aaaaatatct 220740 atctctctct ctatatatat atctatattt ctctacccat tggtagattt tttattatcc 220800 tttttttata gattttttat agagagaata tatatacaca tattctctct ctcaaacata 220860 tatatgtata tactgtgtat agtgggtctg agaacagcac aggtctctta ttcccagtat 220920 gttggactta gctcttcatt ataatttagc tgcttcctta gaacaggttg taaaatctca 220980 aaagcttaaa ggtcaataag tattatactt aatctaaata tttatgcaaa taccttatgt 221040 ccttttaaaa ataaggtata caaataaata aaagttgatt aataaataat aaattagatt 221100 gtcaagcttt ctgttttgga gcaaggtctt gtagaagaag atgcgtttaa tcactatgga 221160 gcaacctgca ggatctggag attaatttgc aattgtcaac aaggtattta gttttcagca 221220 aacacttaag agaacagata atttttttca ccattgatag atatatatat tggcttattt 221280 ataaaaaggg tctctttggg agaaagatat aattttcttc tgttttgttt tcaggttgtg 221340 ctgtcacaga ggaaatcatt actagattag ctgtcatctg acattgattt tggaagattt 221400 tctagaggga gagagactag gaaagggatt tggctttttt cttttttttt tttaacaatt 221460 gagtgtcctg gaccaagggg ccaattctta ttgttccata cttggggaga attataaaag 221520 atgtaactac atcttaaaga acttttcagt attaccctag gtcttttgcc ctgactggcc 221580 actgaatata cccaattaat aaaattttga tattttctga tcttgtactc acctctctta 221640 gtatctattc aagccttttt tattttgggg gacacatctt aaagtgaatt gtatcatatt 221700 tcttaaggtg tgttactttt tcttagttag taaccatgca tttccacggt tagtggctga 221760 atagcctagc acagctctga cacacaattg atgaaaagta attcaatgaa tgaataaatg 221820 aatggatagg cagatgagtt gaacgttcag tggaaactgt ccaagataat aattttcttc 221880 agggcaccaa cttttttact tcacctcttt gtctctgagt ctagaggagt aatttgccca 221940 agccaaaatt ttaacaagta tttgctaaaa gaatcaatca aacaagcatg aataaatatg 222000 caaatgatcc atagcaacac tgcttagtct aatgtttcct aatctagcta atttattctt 222060 ctgcatcccc atttaattaa tcgttatgat ggcatgtctt aaaattagtt cattgtgtcg 222120 gacagttttc cacaccttct ctagtgtata tcgaaaatca gagacattta ttaagctaat 222180 tcatttattt tgagggaaga ttcacttgat ccatcaattt atttacatcc acaacaataa 222240 acataaattt gtagagatca caagtaatga aaaataagac acaaaaatgt tttaaccaaa 222300 tacggcagtt tataaaatat taaagtttca aatgtataat agtttatttc attttgccaa 222360 agtaaaattg gatatagttt tattttcaaa tcagtacttg gggttttttt taaactagtg 222420 atttctgtgt attcatttaa attaaagttc tatgtaagca cgtatgtgtg tcctcttaaa 222480 tggtctttaa gatgcagatt ttctaataat tagctcattt aatgatactt taggatccat 222540 gttgtaaaat tcagtatcaa ggattaccag aataatttga ttttatcttt cctaaccata 222600 ataatactgt ctgaaagtat tatttcatgg tatttctcat ttacaaaata aagaggcctg 222660 agactaaata agaagagaaa gggatagata aaactcttca agctgcaata atctatgatg 222720 tcatgacctt atagtcattt tactattatt atgcagtatt tatttagaaa acctaatcgg 222780 tcttttgttt cttcatttct ctgcttgaga ggataaatta ataatataca tctctttact 222840 aaagctaggt ttaactggaa atattattat tcatttcttc tgtaattttg tattaattat 222900 aaaaataaac ataaatgtta aaaagctccc taaattttaa gtttatgttt atcagggtaa 222960 aaaaaaatcc ccaaaatcat aagtattcat ttctatgatt tatggaagag ctttaaagag 223020 agacaagaaa ttagaaaaaa atattctaaa tggcacatca ttttaatgac ggcagaagat 223080 tattccccct atttagaaat ttgatttcat agtcattatt acaggtttta tttagatcca 223140 attcacgaaa ttacaaaata ttttgatttt ttttgtacat tagtaaccag tttaatccct 223200 tagaaacgtt acactaatat cggttgccag acaatttttc tccaaacaat ttctgtgttg 223260 agataagcaa ccatggtctc cagaatccta agtcatgctc agctttatat atataactgt 223320 ttttgtgttt ttctgtgtca cccattattc ctctaatgtc tgacccaatc caatctctct 223380 tggagacacg ttgctttgct tttctaaatt ctattttttt tttgttttgg ttttttgaga 223440 tggaatctcg ctctgtcgtc caggctggag tgcagtggcg caatctcagc tcactgcaag 223500 ctccgcctcc cgggttcagg ccattctcct gcctcagcct cctgagtagc tgggactaca 223560 ggcgcccgcc accacgcccg gctaattttt tgtattttta gtagagacgg ggtttcatcg 223620 tgttagtcag gatggtctcg atctcctgac ctcgtgatct gcccacctcg gcctcccaaa 223680 gtgctgggat tacaggcgtg agccaccacg cccagcctgc ttttctaaat tcttgcagcc 223740 aactgataac ctgcccaaga tcttcatctc agctgtgctt cttcataact ttggctactc 223800 taatcacgtt gttaaatgac ttactgtatc tcagatccac cagtcccctc cccaacctta 223860 aattttactt ttctaggtct atgacatgat ttgatgtatg tagactctga gccatctaca 223920 cttgatgtat gcagagcctg agagagagag agagaacgat tatgcacaaa ctaaaagaca 223980 cactgtaggc ataaatggga tgactgaagg ctcctcttta aaatcaattt ctctactttc 224040 aagcaagaaa gtaagtggca ttttggagaa aaaaataggg tacatcttta agtagaaata 224100 aattttcttt gtaatataaa ttgtacaaat gctttctatc attatacatt ttccccatgt 224160 cacagagaaa tcccaggatg gaagcaaact ctaatgactt ttatagaatt tccatttctc 224220 tgctacttgt ttttcatcct gctacccaac ccaagtttca acgtggtgta aagaagttta 224280 ggatgagacc agtgacaaat ttttataaaa ggacaaagag tgtagggaca gttgacggtg 224340 caggaaaact ggaagggaat ttaaacacca tacaatctga cccactcact ctacagatga 224400 ggaacaaaga ctcagaaagt taaaagtgat acttggccaa agacgaacaa ctagttagtg 224460 acacacaagg ataaaagtct aagttttcta aagttcagtt tacttctcca cgccgccccc 224520 aacgtggcac attaatcgtg tgatttattt ttctttaact taaaagattt agtattccca 224580 agtctcatct ccccaaaacc cagtgtccag atgaggaaag ctatgtcatc cactgcattt 224640 tcaaccttta taaacattac aatgtaaggg acataggttt atttaataca tatgaattag 224700 atggagttga agttcactct tttatcccgt gagtcataaa ctgaacttgg aaatggagat 224760 cagactaatg agaaaaacaa aatctggact gatgggtcat gcctgtcata acctgtacac 224820 aatcagaatc ctttggtatt ttaaaataag tgtgcttgat ttccactcca gcaacacttt 224880 cgatttgaag gcagtttaca aaaccatagt gtagaaactc atctcagcaa ttttcctatc 224940 tctaatttag taacttctaa tttagtgaga aataggacat cattttgtta attacttgaa 225000 aagtaactta caagcaatcc aggagaaaag ttgtacttct cttgccagtg tatttagaga 225060 atggatcatt agtacatttc tgcatgtgca ttcataatta taattacatt cataaacact 225120 gtcccagagc taggacattt tgctgatcac aattaaaaaa aatagagtga aacaacagga 225180 gagtttcata acctcattgt tttaccacct taacaataaa taaaaatgac tctaaattac 225240 tctgcattga aagaatgttg cataaatgat aagtaattat aattaaaagt aacaatagat 225300 aatactttct atttgtatac tgtgtaatat gattcttaag acaagtgtat gacttgcatt 225360 tctacctacc atttgagaac cctaataaat tttttaagcc tcaggagaat cttacaaaga 225420 atgcacaagc caccctgacc cctgaggcaa atcttagcta gatttaagtt gttaattgaa 225480 tcccttgacc aatatatttt taatgtcttg tcctttatgt aaatagtcaa cagaaaacag 225540 taattgccta tttatttaca atggacatat ttgtagacaa tgtttgaagt gctaaataag 225600 caaatgaaaa acatacagta gttactcttg gtttacaatg tgggaggcac agcagttttc 225660 tatgcttatt agaatctaca tgtgaaatct tccgtgattg gctacaggct ccctgcacac 225720 tgatgcctag aaaacacttc gtgcagaggt agtactcagg gcaaggtgtt cgagtgaatg 225780 aaaaccacaa gtgatatacc tatgctagct tgaaatatta aaagcacaca atttgaagtt 225840 ctgtggagtg agaacccaaa ttcttcaagt atgttagaga atggcagatc tgaacgatgt 225900 cttacattta aaccgtattg ctataattct aagctctcaa tttatgaaat actttatgaa 225960 tttatctttt tctttttaaa taatgaaata ttttaaacat gcaaaaatga tataatgaat 226020 ataatgaaca cacttgaact ttctactcag ctgaagaaat ataagagtac aaatatagtt 226080 cagtagccct atccaatagt attttcttcc cttcttacca cctagaaaaa gtaactatcc 226140 taaattttgt gcttttcctt cctgtcatgt tttatacttc actacaaata tatatataat 226200 atgtagtata taatatataa atatatataa atatatatac attcctcagg aaagcatagc 226260 atcaaaattc tatcatatga catgtattct gaaaatcgat ttttctatcc tattatgttt 226320 ttaatattta tccactttga taaatctgat gtagttttaa tttattcatt catatcacta 226380 ccaccatcga ttggatgtat gaatattcca cattttactt agctgtttta tggctgagag 226440 acatttagct agtttgtttt gtttcatttt gtttacagta acaaacggtg ctactctgat 226500 gattctggta catttctcct tatgcatgtg tttaagactt tccatacagc aatgctactc 226560 aaagtgtggt ttgtggacaa gtgtaaatct ctcaatggtt agttatctat gatgaagtaa 226620 gtacaaccac caagagtaag catgtgaaaa cttttatagc aatttggcat tgctacaaca 226680 tccatgtatg tgatttttta ttttgcaaaa ttatggtttt gtagtagatt aggcacttta 226740 aaaggttttt ataaccatag atagcttaag atgtactgct ctagtttaca tactttggaa 226800 aagaattgct ttgtcacagg tatgtacaag ttaatcttta agttattgcc aattattctt 226860 caaaatagtt gtgttgactt agactcccac tagaagtggg taagaggctc agtttctttg 226920 tactctgttt atttggcttt ctctgtttat attaaaaaaa aaaaaacttt ctctttgggg 226980 aaggattatt taagtttcta cttcattttt cctttctagt agaatttaaa cactgtttct 227040 gtcctgttag agataaccct tcaaaaatgt agcatgcata tttgtctatg attacccttt 227100 cccttcttac gtgttatttt tatccagtat atttctccaa tcccattttt tgcccttcga 227160 gtgaatagtt attattgttt tataccatcc atgattgtct cggattatct aaattttaat 227220 cagatgggtt ttttgtttgt ttgtttgttt tgccccaata ccttttgagc aataccttta 227280 gagaaaaaaa aagtttgaaa tataggaaag aacagtgtat ttttgaaaga gtcataattt 227340 taaaaaggag ttttagaaac aaaaaataat gacaattaaa gtgtaaattt tgatgaaaag 227400 cttaaataac aggctgcaac aacaggcttc ggggataatt ttattcttag taactaagat 227460 attttttgtg ggttagaatt ttttcatttg cctgaggatt tgttaaagca aattcttagt 227520 gttgttttga ttaaaatata tattcttcct ttgaataaaa ttctatgtga caatattttc 227580 ttttcacaga ttgaagaatt gttctactgt ctcctgactt ctattgatgc tatcaatatg 227640 ttgatagtca ctctaattat agtcttttgg agaaaatcta cctttctttc aggctgctat 227700 tgaaatattc tttttgtact tagtgttctg cagtctcagt atgatatgat acctctgact 227760 gtggattcct ttgtatttac ttgattgaaa tgtattagcc tccctcaatc tgagtatcct 227820 tgcttttcca ttctgaaagg catatgtggt tgttttctct ctactttctg tcattatata 227880 gaatattttt taccagaagc ccaagtaaat acatattaaa tcttcttatt ctaccctcta 227940 agttccttaa actgtcatat ttttcatttt gtatctctgt actaaattca ggataattct 228000 ttcaaaacat attagtaatt tattagtgat cctttcagct ggagactgtt gcagcctgta 228060 agttaaggtt tccagtggat tttccatttt aattattatt tttatttcta taaatgcttt 228120 ttacttcaaa aaaattgttc ttttctgtgt ttcaatctat ttttctctaa atgtttcaaa 228180 tgtatgtatg tatattatat actcagtcac taaattatat agtattcatg tggatctaat 228240 tttagttaat cactttgctg attcttctcc atatattttt taattatgga ctttgagttt 228300 atgattagaa gggtcttatc tctggaaatc ctaagatgtg tcatttcctt ttgccagatg 228360 ttcctgtata gtatcaatca atatcaatta cttatgataa tttactattt ggggtctcct 228420 agaccaccta gagagttcaa atttgaactt taaacctata tgaatatagg ctaatccttt 228480 gtaagcatta aaaatgtgta atttttagag gagatgtttt ctccgactca agctcaggtc 228540 aagatagatg agtttacttg ttttttcaag tccacctttc accaaggatc taatccttta 228600 gggattctga ctttgtgtgg tacctgctga tataaactta cataaccatt aatattcaat 228660 cctcttagtt gccaagattg gcaaactctt gcaaaggtgc catgatgcct acatcacctt 228720 tccttctgta ttttagtgca tttttcatat tgattcctga tcatttctca tccatttttg 228780 gaactcactt ctgagtctaa aattaatgtt tgctatattg tgtctgatgt ttctaggtct 228840 tttgcattca tagggctttt cacattattt gatataccat aatgctgaaa atagaagtga 228900 aattctatcc tttatattgg tcatacgctg tgtgatccgg actattccaa acatctgtcc 228960 ttcctgcaat gactttctcc attttcctaa gtccaatcca taaattaaga caactcaatt 229020 tctgcctctt ttgaagaatc ccttgactat cccaccctaa actggactgt catatggggt 229080 aagagtcaga tatcagttta gcagtaatat ctagatttct actcagttgc tggtgtctca 229140 ggggagaaaa tgggtgctac tcttcctcag tgtatatagc tggtacattg tgaggtaaaa 229200 ttgcaggttt aactcacaac atgctcaaat atgcaaaaac aaaaaataaa aactcttttt 229260 actcttgtta ttaatgtcgt ctcttcccat agcctcatgg gcttctcagt tttagaacag 229320 taacttaaca cctaatccat tcagttcttt tttagatctg ttgcttcaat taatccctct 229380 aagtaatgtt cactctgtgt agtaaaacaa catctcttaa tattttatat ttcttagctc 229440 attatcatat tcaaaattct tccttaaaat ggcatctgag tatcggagag cagagtgtat 229500 ctcacacaaa cttgtaccag aaggcaaaag tcaaagtcta gaggtgtggt gctatgtggc 229560 tacttatgtc acggaataag atctcttgtt cacctcattc ctgcttgtcc tgctagaact 229620 cttcgataat gaataaggcc tgtgtaattc aagatcttgt ttcttttgac tttggctagg 229680 gaatactatg tcattgccat aatcagcatt tgctcctctg cctggtggtc cacaccaatg 229740 ccacccagca ggccccacgg tgggccccct ggctctcaca tttgcaccca tgccaagtgt 229800 gtctgaaaat ggtttggaaa acttaaacca catgacatgc ctgagaactg cctgaagttt 229860 tctgtgccta taaatttact ctcatatgct gtacctttaa ttggtgaggg acagtgtggc 229920 tttttctcag tgtccctacg gggagcagga tctgagtcct tctgtcctca ttaacctaac 229980 acatctttcc attttgtcca acagttgtgt tttcactgaa cctggctttc acatttattg 230040 tcttacagaa cagtcctttt tgggatatca tttaatacct tctatgacaa atcctaattt 230100 ctccacattc ttctctccct accgtgggga aagtagggta aatgtccagt acttagagag 230160 gtgaaaaaga aaacacatta ctaattttca gaatattaac ccagttataa tttcagtacc 230220 ttagcagaga tgagataaat gaagataaaa atagctaaat catcagtcct atgcctatcc 230280 tcctattaag tagattatga ttttgcttac ataatattgg gagaaaacca gggctaggaa 230340 attggaaaat attttaataa attctgtgtc atatgtaagt taataaaatt acagaatctt 230400 tgtcttcaga aatacacata caaatacaat gttctaacta cttttatttt ctggctcaat 230460 ggcagaatag ccctagcatg tagtgaattg aaatgatatt cctaaatcct aggccttggg 230520 agaacagcag ttaatagtag ctgtttcttg aagatggtgt ggaaagctat acctaggtgg 230580 aagaaaaaaa aatcctcatt tagctgttct ctaaaggaac tgtggtacat caaattaaaa 230640 tgtaaatgag tccccaggtg ttcaggtgag gcttgcctgc ccattctcca taacctctca 230700 ggttatattg ctataatgta ctttttcaaa aagttaagaa caatgcccca atatgatgtt 230760 gaatgaatat accacattct cttgacctta tttccaactt tgggtaatgt gtgactgtgt 230820 ctcttttcca gctcattctg aggttcaatt taacccagct gtgttatgta aaagtgctag 230880 tgagagaaag agacacacag taagtgtcat cttccccaag ctccctattc tcctaaaggt 230940 agcttagaat ctgaaccctc ctagagacgg cccagtttgg gcctaaatta gacttaattt 231000 agatttggat tcagactctt cctgacgata atctgctggc aggtttgtcc caggaccaga 231060 cccgtcccca gagtgttatg cactgttaga cccttttcct gcccctccac ccattcaaat 231120 tgttgactat tcaggagtcg ctattattcg tgtctcagtc tcttttggga gcctctccac 231180 tccccagttt cccctccctt tcttctactt tctgccaact ctcccttcaa aaaggaggaa 231240 aaaccagtaa gaagtttgcc ttaacttcat ttatgctctc ttagcacttt ctcccttaac 231300 taactcatct tgcctctggg ccaaaatacc taaaatgcct tcacagtgaa atctaaaagc 231360 aatatcaata aaaaggttag actaaatgat ctctgagggc cctcctggac atgagttctg 231420 tgacttcata taaggacaac aacgcaaggg aaaaatccaa tacagtccct taaaaaatcc 231480 tgtaagtatt gaaaatccgt atgtatgaaa tgctgagtgg ggacaggctc caaaaaaaga 231540 aaaaaagaaa aatgcattct ctagtctcaa caaccctatt acctcattat gaagtataga 231600 agaactccat gcaagaaaag ttaaataata cttgagaaat ccattttttc atttatgata 231660 aaggaactgt tagtcttgtg gggctttact tatagatgaa gtaaacaatt acaaagggac 231720 acatggggaa catagaggat actttgggtt tgtgtaggaa aagcacccaa ccacatccca 231780 taggagaagg cagaaatgtc tgttttgaaa atgtgatgtc tcagcaaaac cttgaaaact 231840 gcgtgaagag tgtgtgtgtg ttggggggct ggcggtgtct gtgtgttgta cttgtttggt 231900 agagccatta tcaaattgaa tcaaagggga ataatggtct gttattataa gtgttattca 231960 aagggaatag cacttgtaat ggtccagaag ttggtgaaac agcacctcct tttcaggcaa 232020 ctaatagtac ttcagtctgg ctggaaagca actaagtagc aatataaaac catacagtaa 232080 tgtacagttc aagtgatgcc atagaaaata agtgaattgc caggtgtatg aggtagacag 232140 aatgctgtgg cttcattagt taaataacaa gttactagaa atgagttaca ctaacacatg 232200 tggagaggat aggatgacaa gctattccta gtacagttaa caatgtgatt aaaggcagag 232260 ttggaagaat gcatggaacc ttcagcggat gttaggtggg accatttgac aaaagtcagg 232320 atatgaaaag agattcactg gacaaaattt gccacctcca aacatacctt tctcctaatg 232380 ctaaataaaa agaaaaattt tgataactcc acaaagtgat ccccacttgc ccaccagaag 232440 ggagaggaaa ttatactaac ttagaaaatc agagaaatgg cttctgagta cagaactgcg 232500 cccacattat gcccagctat ggtccagatg agaaatgccc aggttacacc ccagagtttt 232560 gtatggttct gtgtttatag tatgagctaa acctactaaa gaaaattttg tttggagtta 232620 aaagtactga attacgttgc tgatagctaa tcatactatc aaaccctccc acagaatctc 232680 tctctggtct gggccatacc agtatcccac tggctgaact atttgttgtt gtgccctgtg 232740 tgtggatatg gtgaacacat aggagtcagg ttttatattt agaacatgac tcctttgtaa 232800 acatactttg taaacataca aagtccaagt acacccgcaa ctactacatt tgggaactag 232860 cataatagaa tgaaactgtc taggaaatat aaatttggaa cgtttattag gtctagaaac 232920 atctaaaaga ataagtcaga ttttgtaaat taagaaaact cataaggcag cgatgttcat 232980 atttttgtaa ttctttaact atatttgtat cttcaagcta gctgaatttg ttagatttgg 233040 aggggcccaa agtataactt attttggtaa aatctagtac tttaaaattg tatattttta 233100 tgtaaagata tataaaatat agaatattag ctataattta cattcagaaa ataatttgta 233160 taacttataa tgtgcttgga attttcattc aacttaagta tgcaattgtt attgaaatat 233220 taactgttaa taaagattat tttacatagc tttaatgatt acttgttaat ttctctgtga 233280 tacaaatgaa acactaggta ataattcaca atttttttca aaacatgttc ttaatatttc 233340 aaaatttaac aactatgcaa tcaataagcc atttttctca attttcaaaa accctatttt 233400 cctaattata acatgaatgt ccattggcaa ataaagatat gaaaaaaatt aaatttttag 233460 tcccaccacc aacaaataat cactattcat agtttcataa attcatttct agactttctt 233520 tttttttttt gagactgagt ctcaccctgt catccaggct ggagtgcagt gggacaatct 233580 tggctcactg caacttccac ctgctgggtt caagcaattc tcctgcctca gcctcccaag 233640 tagccaagac tacaggtgcg cagcaccatg ctcggctatt tttttttttt tttttttttg 233700 tatttttagt agagacgggg tttcaccata ttggccaggc tggtctcgaa ctcctgacct 233760 cgtgatctgc cctcctcggc ctcccagagt gctgggatta cagacatgag ccactgcacc 233820 tggcctctag tcttattttt aatctttctc cattttaaaa attagtgtta taatatatac 233880 atgtttttat atggacatta ttttgaacat tagtccaagt caatatgtat gctcaaaaaa 233940 caattttagt gataatataa cattcccaac tataaacata ataatttagt tgctttttga 234000 atgctataaa atttaagctg tttctcgctt ttatcttaat aaagatagca ttttgatggc 234060 tatctttgtt tatatatttt gtttaagatg ctgattattt caatgacata gatttctaga 234120 actattgaat caaaatatat aactttaaaa atgatcttgt cacatttctt ctcaagatat 234180 tttgtttgct tgctttggaa ccaagttaga ctaaagttta taaggctgaa cactgtttat 234240 cttgctcatc ctggtaggca gaaaatagtc atctgctcaa attctcattt atatgataca 234300 tagcgaggtg gaaggatttt cacatttata agccatttgt attgcttcta ttaactatcc 234360 cttattttac tgtctttcca attaattgaa tagaacttag gatttaaaac agcgagttga 234420 ataaaataat ttaagaaaca atgacagtaa atgtcacctt ataactgaat gaatacttaa 234480 aaattaatca acttttcatt tactgctggt taaatcaatg atgattttaa ttaacacaat 234540 aaattcaggg ttttttggtt taagtttggc tttgacttct gaattcctaa accagccttc 234600 tcactgaaaa tttgtacatt gtcacagttt tctttcactt actcatactc tttgtttctc 234660 ctgggctaca gactcaaata tattactcag tagcagacaa aaattctgga aaaaaaattc 234720 atgggccaca gaaatgaatt cttaacaata gaatttaagg ggagatttat ttatacacaa 234780 aggaattatc ttccactatg taatcagcca ctgcttataa aatctatcca aacaataaat 234840 atttttgtta aaattaaaat aaatatatgt atatgtatat ttggagttta ctagacggta 234900 tgcaatacat ccccctaata tactaacata aaaatacaaa aagtcttggc atattggagt 234960 aaatattaaa taattattct gaatcttatt tgtattaagc cataggtgga aactcagtct 235020 ttttaacttg taaaagttgt gggaaaattt atttctgact ttgtcatggg tctatttcaa 235080 tgctaagaaa agccaaatta tcaagctcaa taatagagac agtgcaagct ttcaactgga 235140 aagggtgaat actgtaaaat gaaactttaa gcaactggaa tatcttctta tattagaata 235200 ttttcccatc agcgaaatga tagttgtgga attcacactg aagcagaatt ttagtactca 235260 catctatcac cttccaggca tctagaaatc aaaacaagaa aagtctttca aaagaatgga 235320 ggttttactt tttcctagca atttgaaaaa taaaaatgca ttcagtattc ctttcccaaa 235380 agttttagtt gtgattctct aggtgtctgt ttattgctgg ccactggacc attataaaag 235440 tctgatagct gctaaaacaa gaatcctaat cagatttaac aaaccttctc tgaaatggtt 235500 tatcttgtca aagctacaga ggaagctaaa ttgaaaagca aaattaatct tcctttctaa 235560 aggtgaactc tagcctaaca tgtagtctgt gacagtaatt aatgctgttt tagctttctt 235620 tccatgctca gcccaagaaa cctagtagta atttaggtat gtggaaaacc tgtgttgaac 235680 ttcattcatt tccactacag gatgaagaaa gattggcatg tctgcacact ttcaatctgt 235740 cttaaagaag cttctaaaac acatttcctc ttcacagttc tcatttcagg ttaatgtaag 235800 agtagatatt tttctgtttt ccagtgggga gaaaaatgat tgtctatcac ctcaataatt 235860 tataatctca ttgacgagat ttttaggact catttatgaa ataattaata agcatttgaa 235920 gttattttcc ctaatgtact attaatgttg aatacaagta gatgaaatac aatattttta 235980 gctatttaac agtactcact tttgtatact aaaaaatcca gtttttaata tttctttctt 236040 cttttgaaca tagacttttc ttgctttgca ggtcaatgga attgttcttt tcctcctttc 236100 tagggcaaga aaaatgtcag ctaaggcctt agtatgaaaa aagggagcag gggatggata 236160 tgaaaaattt agaaaaattt aaatcaaaaa cgataaatag agttgaagta agacaacact 236220 gaggaagagg aagacctcca gattagctct tctgtttctg ttaatcaata ggtgtctaag 236280 gacacttgca tcaagatagg aaatacagaa aggagggcga gatttagagg ggaaaacaaa 236340 gagctcagtt ggggtatatt gcctataaag tatatgtgga atgggaaatc tgatatgcaa 236400 atcgtagctt aagaatgaaa tcagagctta agaaatggat ctgggaatcc ttaacaccta 236460 ggaggtcatt gaaaccgtgg gattgggtgg gaatacctaa gtagaatggc aatagtctat 236520 aaatctatgc cagttttcca aatggaaaat tattaaattt tttttaattt tagaactcct 236580 caacaatcca ttattgaacc gtattgaaaa tctggccaaa taataaaagc acaaagagta 236640 gaatttctag aatattcata tctacttctt actaccttct ttttcatcac caaagcaact 236700 taaccatgtg taagcaacaa ttttattcct taaagaaata atgaagccaa cagccataat 236760 tagggataat gtgtaatttt ttcctaaatc aatttaattt cagatagaat tcctagtata 236820 aaacagaact ttctctagct aagttagtaa actctctttt tgaatgtgtt tgctggtaac 236880 atatttttat gtcaatcaaa gagcaattaa aacaccatgt ttccttagta attgaagttg 236940 cagtacatta cagattgaga ttttattttt aaggtgtata tttaaacaca attaggtatt 237000 tgtctaccat ctataacaaa tgaaaacaat actgcaaata ttttatatgt ttttaaatgt 237060 aatactagta aagtttatta aggtatagta agctagcctt tgaattttgg agctaaatct 237120 ttccattctt ggaggagaat acactgagga cagtgttcaa gcacatatca catataaaat 237180 ggaaaaaaaa agtagtttaa agtagatagg atgttttctg aaagctgata gtttacttat 237240 ttcttgtttc ttttcctttt atgtccagtt ctttgggcta tgcttctttc tgggctcaag 237300 tgatcctccc atctcagcct cctgagtagc tgggataaga ggtgtgtgcc accataccca 237360 gcttttactt gttttttaga aactgttctg ttatatttct tgaagaaagc aagaataata 237420 ttctcacaac cactttttgc acctttcaat aaaattttga aaatatacaa cagcaaatgc 237480 tttgccatat aataaaagta tagtatttat atggaaccaa aaacaatctt tcaaaactca 237540 gcaaatttaa gaacaaatga gaatgaggga acaacattaa taccctcaca gaaaacagat 237600 tttttaaatt aaaaataaat tataaaaacc accatatttt attttattgg gtcataattt 237660 atcttcttgc aatctatata tctcaaggtc taattataat ctggcataca tgttgtacca 237720 gcaatatcta tagttcactt tatttatatt tttgagtcct agaactcagg ataaatgaaa 237780 actagtgacc ctacacctca aaaatcaaag aattgttgcc aaaactcaat ctccaactcg 237840 taatcttcac ctgtttggtt ctgaaagtat ctcctcagta tgatgctgga ctagtccaac 237900 cctgtgtagt ccctgctgtg attccaaact aaactcaatg ttattctgca gaaacattac 237960 caaaaaaaaa aaaaagtcct ccagctcaac ctcctcctcc tcctcaccct cctcctcctc 238020 ctcctcctca catttttacg tcttaattct gaaagactga ctcaatccct ttgtcttatg 238080 acattttgta atatctagaa tggcttttga tattttcagc ttttaccttt actgcttatt 238140 tcccctttac tggcctctgt ttattcattg atacaaaacc acagttcaat ataatatgaa 238200 atgatcatag gagttataaa aacttcagaa aaaaatggat aactagtatt ggaatattat 238260 agataaagtc gttagggagg ttcttttgaa aaacagagtg ttagcagaga cctgaataaa 238320 gtgaagcagt gattccagtg aaggtctagg cagaggaaac agatgtgcaa aggccctgtg 238380 atggcagcga tggacttggt gtatttagga acagagaggt ggctcaattt cagtgagtga 238440 gaaaaagaga agaaaacaaa gtttaaaaag tagcagaggc caaattagtt aaggttttgt 238500 aggctgtgga gagaacttaa tatttagcac cttcctcaga tctctaacct tggtggaatt 238560 tcaaacatgg tttggatttt cccatcagcc accatgcctc agactttctt ggatgaactt 238620 gttaaacaac cttccagttc atctaggccc tgaagctgta taccttctgc ctctcatctg 238680 ttgtggtttg gctctcactc gggagacacc tattgcaaat ttctttctag gcccccaact 238740 cacctctaac caaacttact ggatcttttc cctcacccat ttgaaagtat gtagtaaaac 238800 agaatgaaat tgcattttat tacaaaatat cctaatagat tctcctatgt gggtcctctc 238860 caactctgac tccacccccc tcctctgcaa ggaccctaat atccaaaagg acatttcaac 238920 ttccagttcc tctcccagtg agacttatag cattcaaatt cttatgtctg gtttataaca 238980 ttttgtaata atttcttttt atctcacaac taaactactt tcacttttat tcttaaaatt 239040 gacattaatc catttgtcag agaacatgaa tggaaatgct acaaaccgtt catcctttat 239100 aatgttaata aggtacatgt catgaaaagg ttattaggaa aaattaagtg cagtccatgt 239160 ttaacatatg aaagggagca tctgaactca cgtgtttaca atatttaatg taactttcta 239220 agataaagca ttccagagtt cttaactttg atcagctatg cctgagtaca tcgtttagta 239280 cacagataat tgtatggatt attaaccttc aaagaagaca agttacaatt aactttacca 239340 ttgatagtcc aagcaaaatg ttaaagagat taattttata gtttgttagg gaacatgaca 239400 tttaactaca gattgaataa tggcaagatc attaaaggtt atttgtgtcc tgatttagaa 239460 gttccatgta agaaatgtta aaaacaccaa agtaagcann nnnnnnnnnn nnnnnnnnnn 239520 nnaagtactt ttttaaaatt tgggaagtca gaacagatac aatatattca gatgattatt 239580 ggcaaatgaa tttggagcca aatgcccaga acccttgact ggtgaattta aagcttcatc 239640 ttaagtgaag gaactttcag tctgctgata gtatttgccc ctgttatcta taaaccactg 239700 accacccgta ggcctcagac tttcataaac tggagcatcg tgaaccatac attaaccaat 239760 cacattcttc tccaactagc taggggaaca aaacttcagc taggtattgt tctctcaaga 239820 gtattgatat gaacaatatg agttaccctt ttttcccctt tccttttggc taagttctta 239880 ttgaatctta gagcaaaaaa gaactttaaa aataatatag tacaaggata ataaataaca 239940 tattttaccc tgttcttttc tccccatggg agacatcact actccatgga atgtcctttc 240000 ccatgaagca tagaatgcat ctcaaaattt ctagtagagc atttaaggca tccacttcca 240060 atcaactggt actccaggta aaaactacct gccatacctg atctaggcaa atttccattt 240120 tacagttaac aaaacaggga cccagaacta cttgcaactg ggttagagac acagcctgta 240180 accctgaaat ggagtttgtc tgtattggaa gtgttaattc atgcaacaag taaaacttcc 240240 atcttatttg ccccatattc caagtttctg aactgaaaca tgtatgtaga tctgtttaat 240300 acagagctga ctttgaaagg ctcgcttctt tagcatttct actgtgcaca aaatattaga 240360 gcatttaggg gcttgtcact gaaaccaatt cttttcatac caacaagata aaatgttcct 240420 aaatactggg agacttgctg ctgtttagaa aatcataaca cctgtaaaac tggcagagac 240480 aaaattgtcc acccccaaat tatctggttt tttcatgagt gaatgaatgt caaagtgggg 240540 tgccgtaatt tgtgaagtac cctaaaggaa gatgctggac ctattggtga tcaccttcct 240600 ggagctgctt ggtctcattt aattgaatga gctccctatt tattttcctc taagccccag 240660 tgtagagaat aaggcaatca ccagaaggta aaaataacat agtgtacacc ttttgcccct 240720 aagctcataa caggtggtgt tctgcagaga ttagtcctgg gtgcatttaa catctctgta 240780 tgtgattgat tacaagctag agagagtggt cattaagttt gccaagtaca tcacatcatc 240840 aggatgggtg agcaccttga aagacaggac tagaattaaa aatgacctta actgcttgaa 240900 aaatgattac aaacaaatga aattgagttc cctacaatca actatgcagc aaaatactaa 240960 atagacctcc aactgcacaa attcaagttt gaaatggatg aattgagccc agtgctggtt 241020 gttacctagt gaattgtaat ctgtactttg gttgacatgg cttcactgat tagaaagtta 241080 gcataattgt gtattgtaca attaagaaaa gtagagtaat ttggactgta taaaatgtac 241140 aatgtaattt ttgtgaaaca tagtatataa ttttgttaat aaaccaatga aaaagtagat 241200 taatcattaa gtaatatttc caaagtaagt tatgagatac ataaattaga aataatgaaa 241260 accgtaaaaa aaaaagagac cacatgtaga tagaaataat aaataattac aagagtagga 241320 aatataaaaa gttaggaagc attaataaaa caatttggaa attttggaat acaaagcttt 241380 tcactgtcaa aaggaatgaa aataatatat attaaatagt atcatagaga atttaggtca 241440 caaataaaaa caaatgctct tgaatgctat aaattctaat ttgatttcac aacattattt 241500 catagaggaa aggttacact gttaacttac agctttgcct ggatccaaca gtgcagaaga 241560 cccagaataa tgtcatcttg tagggggaaa tacttatgtg gagtttaaat tcccactctg 241620 aagaaaggct aatttctgag aattgtttga ttacatgagc tttctttttc tttttctttt 241680 tttcttttta ttatttattt atttattttt tgagacagag tctcgctctg ttgcccaggc 241740 tagagtgcag tgacatgatc ttggctcact gcaacctcca cttcctgggt tcaagtgatt 241800 tccagctaat ttttgtattt ttagtagaga cagggtttca ccatgttggc caggctggtc 241860 ttgaactcct gacctcaagt gatccacccg ccttggcctc ccaaagtgct aagattacag 241920 gcatgagcca ctgcgcccag ccttcacata agctttcaaa gcaatcaatt acaaatttac 241980 tgtttcaact attatgaaat tataatattt tctcaaactc tccctcaaaa ctcataaaat 242040 ctagaatctt taatattatt agttcatata gaacaccaca aagaatgtgt gacattcctt 242100 tataatgctt atattccata aaatcttcct tctgtaaagc aataaaaact tgggtgaaac 242160 cttttatact atatatgaaa ctttaatgct agaaagaact tttgacctaa tctcagtaaa 242220 caatttcatt tggcatattc aatgtaacaa tggcttttat agttataaat acaggagtga 242280 tggttacaca gtactcagca gtgtgcagta acatttttaa ttgaccaaat tactcagtat 242340 tgggtctttt aaattagttt aagtgcacat aaaatacata tcccacatgc tagtttatag 242400 atgctgctat gattttaaaa tactgctttt cttaaatacc tagaagggat tttttttggc 242460 cacatataac actaaaataa tttttagtga ctttttgtga atgtagatat ttatcatttg 242520 tatcactttt ccatcaaatt agtctctgta taattgaagg ggtttttctc acttgtgttc 242580 ttactttcct gaaaaggtct cttttttgca agatttcact ccgttactat agtctagctt 242640 acttacaaaa gaaaaactag atggtaacat ccacattaac ttcataggca ttgaaaatca 242700 attattcaaa gtctcttcag aacccaccta gagtttgaac accttaactt gtgtgtaaag 242760 tgttggcttc ggcagcttct cctttaaaat gagagaaatt tttctatctc tgttatcagc 242820 tatctctaag gtggggaaaa aacggaaata aacaagagta taaatgcagg taaaggggaa 242880 gcaaaatgac aagagattgg ccaggaatac tgggatttag gggtagaaag attctctggg 242940 aaatagtgta caaacagaac tcaaatttag atttcataat ttacatactt gattcagtac 243000 atattcaaaa atactccatg tttcaatttg tagaaaaaaa ttaagttttc aaaatgttgt 243060 tttaaatttc attcttattt ttagttgaca ataattgcat atacttatgg gatacaatga 243120 aatgttccag tgcatgtata cattgtggaa tgagaaaatc aggtcaatga acttattcat 243180 caccttacat acttttcatt tctttgcagt gagaacattt aaaatccatt cttttagcaa 243240 ctttgaaata cacagtacat tgttattaat tatagtcacc ttgctgtgca atagatcacc 243300 agaatttatt cctcctaact gaaactttgc accctttggc caacattctc caccaacgct 243360 gccatttaca ccttcatacc tccccagcct ctgataagca ccattctact ctctacttct 243420 ataagtttga atttttagat tccacatata agtgagacca tgtgatattt gtctttcttg 243480 cctggcttat ttcctttagc ataatgttct ttaagttcat ccatgttgtc acaaatgaca 243540 gaattttgtt tctgtttagg gctgaacagt atttcattgt gtgtatatac cacgttttta 243600 atcaattgat catcgagcat ttaggttgtt tccttatctt agctgttgta aataatgctg 243660 ccgtgaacat gggaggagag atatctctac ggtatatcga tttcaattca tttggatgta 243720 tcacccaaaa gtgggactgc tggatgacgt ggtaattcta ttatttcctt atgaatttcc 243780 acactgtttt ctaaaatgga tgtactaatt tacattctga ccaacagtgt acaaggctcg 243840 gacttttgtc cacatcctca caaacgctta ttttacatct ttttaaataa ccatttcaaa 243900 aagtgtgaag tgatatatct ttgagatttt attttgtatt tccctgatag tagtgttaag 243960 catgttttga tattcctgtt ggccacttgt atgtgttctt ttgagtaatg tttattcagg 244020 ttctctgcct ggttataatt gggttatttg ttttcttgct gttgagttgt ttgagttcct 244080 tgtatatttt ggatactaac cccttaccag atggacagtt tgcaaatatt ttctcccatt 244140 ccatagatca tctcttcact ctattgattg tttcctttgc tgtgcatagg ctttgtagct 244200 ggatgtaatc tcatttgtct atttttgctt ttgttgtctg tgtttttggg gtcttatgta 244260 agagattatt gatcagatca aagtcattta gattttcccc tatgttttct tctagaagtt 244320 tatagcttct ggccttacac ttaaggcttt aattcatttt gggtgattct tgtgtaagag 244380 gtgacatagt ggtccaattt cattattgtg catgtagaga gccagttttt ccaacaacat 244440 ttactaaaga gactgtcctt tctgccttgt gtgttcttgg cacctttgtc aaaaaaatca 244500 attgaccata gctacataag tttatttctg ggctctctgt cttattccat tagttgattt 244560 gtctgttgtt ttgccaatac catgctgctt taattgctat aacttggtaa tatgttttga 244620 aatcaggtag tacaatgcct tcagtttgtc cttttgctct agatttgctg tggctatctg 244680 ggtcttttgt agttccacat agaattctct gtctgtgaag ttttgaatga agtctgtcat 244740 tggagttttg ataggggttg cattgaatct atagatccgt ttggataaga tggacatttt 244800 aacaatatta attcttctaa tcaaaggaca cagaatttct ttcctcttat tttgtcatct 244860 tcaatttctt tcatcaattt atttttatag ttttcagtat acagatattt aacctggtta 244920 gttaacctta ccacttagta ttttattttt tatgctatta taaatgtgat tgttttctta 244980 attacttttt agaagttcac tgttaatgta taaaaatgct attgatttat tgattttgta 245040 acccgtgatt ttactcaatt tatttcgctg ttctaacatt tcttggtgga gtatttaggg 245100 ttttctatat acaagatcat aacattggca aacagagata atatcacttt ttccttttct 245160 gtttggatgc cttgtatttc tttttcttga ctaattgctc aggctaggac ttccagcaca 245220 atgtgaatag aagtggtgag tgaatatcct tgccttgttc ctgatcttag gggaaaagtt 245280 ttcaactttt caccactgag tatgatgtca actgtaggct tgtcatatat ggcctgtatt 245340 gtgttgagaa actttcctcc tatacctatt ttgttgagag attttatcat gaagtgatgt 245400 tgaattttgt tcaatgcttt ttctgcattt attatgatgt tcatattgtt tttgtccttc 245460 attttgttaa tatgatgaat catattgata tggtttggct gtgttcccac ctgaaatctc 245520 atattgaact gtaatcccca taatcctcac ttgtcaatgg tgggatcagg tggaggtact 245580 tgtattatgg gggcagttta ccccatgctg ttcttgtgat agtgagtgag tctcacaaga 245640 tctgatggtt ttacaagcat ttctggaatt tccccctgct tgcacttact ccattctggc 245700 accctgtgaa aaaggtgctt gcttctcctt tgccttctgc catgattgta agtttcctga 245760 ggcctcccca ccaagtaact tctttcatta tgaatcaaat aaacctctct cgtttagaaa 245820 ttacccagtc aattgattat atgagtcaat aaaacttctt tcctttagaa attagccagt 245880 cttgggtgtg agaatgggct aatacacaca ttcattgatt tacatatgtt caaccatcct 245940 tgcatccctg ggataaatcc cacttgatca tggtgaatga tctttttact atattgttga 246000 atatggtttg ctagtgtaat tgtctcttgg tatctgtggg ggattggttc tggaatccct 246060 catggatacc aaagtccaca gatactcaag tttcttatat aaaatggtgt agcatctgca 246120 tataacctat atatatcctc cagtatactt taaatcatct ctagattaat ttcaatgtaa 246180 atactatgta aattgttgtt atattgtatt gttcagggaa taaggacgag aaaagtctgt 246240 acatgttcaa tatagacaca gcacagccat ccttcttttc tcaatttatt tataatatac 246300 agtttactta atctatggat gtggaaccaa cagatatgaa gggctaactg tgttttttat 246360 gactgttata tctttattca tcagagatat tggcctatat ttttctttcc ctctagtatt 246420 ctcaactagc tgtgttatta cagtaatgct ggcctggtaa aattaatttg gaagtagtct 246480 ctgttttaaa cttttctaaa tgtaaattta ggttagctat aatctctttt ccttgccctc 246540 aactcaaagc cccttcccac aagaaacttt ccttgggttg gggatgggga gagtaggaaa 246600 tgagagagag agaaagagac tgacaaagac taaaagtagt taaagcaatt gtatgaagcc 246660 agtggttcca aaggaatact tactggttat aaactagcat gtctgtgagg taaactagaa 246720 tgttctttta aagacgcttg aaaggacatg ccctcacctt ccccaaattc tgaaatttgg 246780 ggccttcatc aaaatttcaa gtttaatttg gaaggtctaa tttgaaacta tgctatgaaa 246840 ccaaagaaaa gtgttcccag atgaatgaag acctggtccc aaaaggtcat ggaagatagc 246900 actccctgca caaagtgatg ttactaatgc catcctttat acaaaggatt agccagtcaa 246960 ctgcaagaca ggaaagataa cactagaatg agaatatgca acatttgaat gaaagtgaga 247020 aatatgagtc caaaaatgct tcaatgagta tttcctttga gtcccatgtc agtcctcaaa 247080 aagtttcaaa attttttcag cagtatggat tagggatact caagctgtag aaaccaaaat 247140 ggtaaggaaa tcatcttcat tttcatttag aaatgagttt ttgcaaaata caaaatgtca 247200 aataggttca tggctgtatt attttttgtg attaattatc aagactgaag atttgacctg 247260 aaagcaggaa aaaaaacatg aataaaacat attatcacat atgagaagtg gcgattctta 247320 ttgctgccta cactattcca gcttcaataa ccaaagaacg atattgaagg tggcatttca 247380 gaatgacata cagtgtcttt tctggaagga aagaaaaatg ttgctaccta caaatgttaa 247440 attgggtcac atttttgcta agatttgaca aggactagac taagattgac tctgcttgtt 247500 gtgagcattt ggaagtgttt aatatcccta ctcttcaaga gagccatcac ttttcaataa 247560 tacagaacac ctgtcacttc tgtctgccta tattattatc cccactatac agaggaggaa 247620 aagtggaact atttgattga agcaaagcaa attcttaaac ataacttcca ctacttatgc 247680 cagagatcag aaaattaagg cccatgggcc atattcagcc cacaggcctg ccccttgttt 247740 tttatatacc ctcgaactaa gaatgttatt aatattttga aagagttgcc aaaaatatga 247800 ttatgaagtg atagagacct tgtgtggctc ataagtccta aaacattttt attttttggc 247860 ccttggcaga gatataaatg atatagttcc tttaaaatat aacttagatg attgattatg 247920 agtaaactaa atgatttaaa taaaaataga atgtatctat ctgaacctag aaaatagaaa 247980 taggctgcag atactcattc atttacaaag tgctgtgata cacttctgat gtagattagt 248040 ggatgtcaaa actacatcaa tattttgata acaagaacaa atacacattt ctatttgtaa 248100 acgtggccag ctcaacagaa actaagttga taaggccaat cttcgccagt atagttaata 248160 aataggagtc ataaataaaa actatatatt tattttaaca tcattatgct aacccagata 248220 tatgaataaa gtagtgctaa attctctggt aagtaaacaa aggctctgag ggtccctgga 248280 gggagagata gtaagcatta gctgcagcca attttttcag cttgcatttt ggcttctttg 248340 agccagatca cctaagtcct gacacctgtt catgctgcta aatttctatg cctgcccata 248400 gcctatagcc aagagtccat tttctcaaag tgcttcaggt tttgtggtta aaagagtcat 248460 gtggaagccc tcataaaata agtgtgcccc ttgcttttcc atcctccccc atacacgtct 248520 gggaactata tttactaggc tggacccttc agtacttaag gatatctctc tgactctggt 248580 ggcctccacc cctttccttg gcgatatatt aaatacttac aaccatatca gcctccttgc 248640 cttaatataa ctctgatgct ggttgcagat tgtgggtgaa acctttatct atcaggagac 248700 taggaataga tcaggaaact cagcacaact ctgaattaag taacctttaa gctgtgggag 248760 acttgaatca ccccaccaac ctagtacact attcttaact ttctttgcct atatttttgt 248820 taaattgaaa aagataagac tgcctcccct tctcgctttt ccggtcaatt tagtagaagg 248880 gaaaataaaa gaggattgaa tttccatcca ttctgcatga gactttcgtg attacttcaa 248940 catttaaagt ctaaaaattt ttctcagaaa gttactaact ggacatatat aacaagctgc 249000 ctgaaagcac cagagctagg aatgtaatct ccgagaggaa gaaaaggaag tgctaacagg 249060 aagaaccggt gtattgactc ttgagtagaa aaatacatca ataatgagga ttaaatttta 249120 aaaacacaga aaaaaattat ttgctacttc taaaataaga acatatttca attattattt 249180 taattttaat aacaaatatt ctatagactt tttgtggcag tcaaatatgt acagctaccc 249240 atttttgaca tagtagcatg atgaaactta ggacctatgt caccccatga ctcactgaga 249300 gttaaagtta ctcatttagc tacttacgag ccactgcatg caaattaatt gcaccactat 249360 gaaggtactt gctatttatc ttatcccttg catggggtct gtttttttgt gagtgtgtgt 249420 ttgtgtcctc cacaaaatat gtcgctgttt aattctaggg gataaaagct ggaattctgg 249480 aataggaata gttagaagtg actctagctt gttttttttt ataaaaataa ataatcattg 249540 agctctttta tatgcttgta atatgctggg cacagttata agcgctgagg agaaaaatgt 249600 gaaggagagt ctgtgcactg ttgaaatcac attctattgt gataagacac aaaaaataaa 249660 gaaaaataaa agaaatgcat aaaaataaaa gaaatgtggt atagataata aattgggtga 249720 tgtataagta agataatctt gttgagaaag gtgaagtggt tgctcaagga agatttctct 249780 gggaagaggg tttagctgag ccttacaggt ggagagggag acagccaacg aagagctcgg 249840 gaaatgcagt cagaaaggaa gaaccagcaa atccccaagg gcattggggg tgagtatatc 249900 ccaggaacag aaaatttatt atagctgaaa cactgagtgg taggagatga tgtcaaatgg 249960 taggcaaggg ccaggccatg gtgcttatat ggacaagagt ttgaatttta ttcttagtat 250020 attgggaagc ccttggagga cattaatgac atgctctaat ttacatattt aaaaattact 250080 ctaacagatg tgcgtggaaa taggttaaaa gaaaggaaga ggagaagtgg agactattac 250140 agtcacccag gctacagatg gtactcacta gggtaatgga ggagaaatgg agatcagtgg 250200 ctgggcttgt tacatatttc agagctctaa tttagaagac ttcctgctga tagattggac 250260 cagggacttt gtgctgataa tttgggaaaa taataaacaa taactctaaa gtatttgtct 250320 tgagcatgag gaagactaga gaatatggct tttcatttat ttccctttgc tattattctg 250380 ggtcctaggt cccctgtgat atgctctgtg tcaccttccc agtccaggtc aagttaggta 250440 tgatccatca agatgcccat cactttaatc tcattccttt gttagagcta aaatgtgaat 250500 ctcaatgacc ctttctgttt ttgtctccaa ttgcagtttt taaaatactt gctctagctc 250560 tttcctgttt gcagtgattt cacttgctca agcttcagga ggtgcggctc tcctcccact 250620 cagatgcact cggataaatg cctagttcaa ggtgtcttct ttcctgccct gctgtggttg 250680 ggaactttct aaaactctga tttaggtggg acaaaactat tttcaggtgt atttctacat 250740 aaaaggctct aaaaaccaat tattttccag cttctgtatt ctaaaattgt atatatcctt 250800 tccctcttct gcccccgact tgcacccaga gttactcact tagagctcaa ctagcatttt 250860 gtcccttaac aaacactttc tgaattgaat taaaataatc taattttcca tataccatgc 250920 atggttttct tttttgtgga ttttattttc ataagttcat tcctcaatat gtcggttctt 250980 accttaatat actgacttta acaagaacat aactgtttaa gggaacatac gtacccatgg 251040 atattccaca cctaaataat acagttagta gcagacatag tactttcaaa atcatcatta 251100 cttgtcactt tttgtattag aagccaccca agtataaaat ctgaaaattt ggtgtcttct 251160 tatgttaaat tcatggtttt attttgaaac tcattttacc agtagactcc ttcctcagat 251220 agaatcctat gtgggattcc aatccctggt acatgaaatg catgatgaag ctgctctgct 251280 gggggagtgg aggagctacc ctttcaaccc cttctgtgca tcctatgatt atgcttgaga 251340 tatttatcca tgtgagagtt tgtgctctac aaaatgcact tgaaaacctc agtgttaaaa 251400 aattattcaa tttctgtttc tttaaaacat ctggtttggg aactctttta tttgttctac 251460 ttttatgact ataattcact aatcctgata atgagacaca cacacacaca aacacaaaca 251520 cacctctcat tcctaggatc atggcaatgc atctaagcta caaagaagaa tgttcatttc 251580 tctgcctctt gttaaacatt gaagagactg ccttctacag aagtggggtt ttgttcagta 251640 aatagtgagg acagctttct agacctttct cagcgctctc ccgattcaca cggtttatgg 251700 cctgcactgg gagtcgttcg gtctacaaag ccccagagtg ccatggccac attgccactc 251760 tgcatttgga attctagttg catttcttct acatcagcct tgtgaggtaa aggtgggcat 251820 gaaatattta gcacagagtc aaaaatgaag aatttagacc acattttggg agccacctta 251880 actacccaga ttatctactc atgaaaatgt ggttgggatt aggcagggtg tcagggctcc 251940 tggttagcca ggctgtgctc cttgaggata gtaacccagt cctaggatcg cacccaccat 252000 tggagggaga ggaaagaggg taggtgggtt aatgacaata ccattattgg attttgttaa 252060 aggacacaaa attacagcta gataggagga acaccttcta atgttctata ccactgcagg 252120 atgagtgtag ttaacaatga tgtattatat agtttcaaat agctagaagg aggatatcac 252180 acgttcccaa catgaagaag tggtagatgt tgagatgaca gataattact ctgatctgat 252240 tagtatacat tatatttatc aaaacatcac tatgtacccc ataaatatgt acaattatgt 252300 gtcattaaaa ataaaatttt aaactataca aaatacttta aaatgaatct agaatataac 252360 aagtaaagac tgaattaaga gggacaaatt tgatttcaac aagaggttca taaattgatt 252420 acacacatct ccacttgaca aacacccaag ttttgttttt gagggggtat aaggaaaaga 252480 ccatagtaat agtaacatag taatatatta atcagttaat agtaaaaaat taataaacat 252540 ttacatctgc tttacattat gtttaatagt gaagctacta gaatctgtat caaacagaac 252600 ttattacatg aagataacat aaaaattgaa tttttttttc agaaaaataa ccaaagaaag 252660 atttgtgctg tttcttaatc ttttccctaa cttttcttct aatatcattt tgtgggtaac 252720 actcagaggt gtgaaggtca gtagtggcgt catcattgtc cttgcctctt ttctcatggt 252780 aggttgtggc agtgctttag ttgtctacat tccatggtct ttcaacagct agttcagtgc 252840 aggagcgatg ggaggaagga ggcatgggat tgccaatgcc actagtattc ctattcaata 252900 gcatggctgg ctttcatttc ttggcagcaa ttagagatat aaggctgttt cctgggaaat 252960 gcgttgtttg gtataagcag tagaacttgt aggtatgtcg gctgttagct tgtattctta 253020 tatatactga ctcattatgt gttcttaggg tgtgagaaaa cagagagcta aatgaatttg 253080 gcttcttgtg gatacaaagg caaagcaaat gaaagttgac acacattgtg gtaagaagta 253140 aatgtttgac tattccatag atagaaccat ttactacaag gcaaaaaggg agatgctttt 253200 ttttgttgct ttttaccatt gcacacacta gtgtcttttc tcgaaaaaaa tgggaaaagg 253260 aaactatata aaccaaaata gactcataaa acacagagag ggttgggatg acacaatgtg 253320 cttgcgtgtg tgtgtgtaac taaatataaa cgtgtttttt ctgctgcttc tgctatctta 253380 tattttttta aaaaaattct aaatgctata aggacaaagg cttcacaata aaattgatac 253440 taacaacaat ctcagcaatt tctgcaacat gaactctgta ttagttcttc cacagcaagc 253500 tgtgagagct ctaggaagtt attgtgagtt gatgtcatag agactggagg aagaaaatct 253560 atgctctaaa ggaaacctca ttgcactgta ttctaaaagt tttgtttgcg tccaatattc 253620 ccatgacaat ttcccagaaa aataatatct gaaccttata atacctaccc aaataaaaga 253680 tgtagtcaat gtgtttgatg aaatctacac aagttttcct aatgggactg gcaggtcatt 253740 cataaatatg aagtaaatgg cataataaac aagcagaaaa ttaaattcat aaattacagg 253800 caaaaacatt aagctatacc atgacagaat tcatgtatat gaattcattt aatactaact 253860 aagttttgct tacaagtaac atttaatcag tagaattagt gatggaaaaa caagcagcta 253920 tttcttctgt aggaaaaaat atatgtgtgc agtgtataaa tcagggctta aattggacat 253980 ggagtcttga ctaaattttg gtcatgacga tgatagaagt atgcaaaaaa ggtatagtat 254040 ggctaacttt acatgtaaag ttgacataaa tatttcttat tttcattttt aaattttaat 254100 gggttttatg gcatggtgaa aattatttat actaagaaat tcatatattt tgcactattt 254160 ctaattttat aataaactta caacttttaa tttgtgttga ttctaaattc aacattgtat 254220 ttctaggaga aaaaagcaaa aaaaaaaaaa aaggaaagaa accattatca ttatatcagt 254280 tatttactgc atcagttaat caggcatttc aaactttctc aaatttagtg gcttaaaaca 254340 aaaaccattt atttgctcat gattctgcaa tttgggctct gatcagctgg gtaaccctgg 254400 ctggactcac ctggcatcac tccccagggt tgcagtcatc agattttgag gggagatggg 254460 ctgtctaaga tggctccact aatagatttg agggctcacc tgggatggct gggatggcca 254520 gggagcctgg gcctttctcc ccacgtggtt cattgtccta aggtttttca gagtctggtg 254580 ctctcaacgt tccaaagggc aaaatagaag ctataaggaa ggccttttga ggtctcatct 254640 caaaagttgc acagtgtcac ttcctgcaca ttctattagt caaagcaaga tgcaagatca 254700 gcccagattc aaggagagtg ggattagaga ctccagccct tgagggtaaa gcagtgatgt 254760 cacattgaaa atgggcctat aatgtgcata taaagatgga agaatttatg gccacattta 254820 ataatctgtc acaatcagca aactaaaagg atattacttt gatgaactga tagtaatcta 254880 atcataacta tatgggaaga aaatcagaaa atttaatttt tttaaaagga aaattttatt 254940 atgtgaaaat acatttcagg gtttgataaa cgctttaagg tattgtgaga ttctggacaa 255000 atcattctgt ggctttatga gttcacacat ttattgcatt tctgtataat atatatgatt 255060 tattcatttt aaataaatat agataagact tgtcaacatg atcaactcca acactattct 255120 tatttgcctt aatattaatc taatagtgct cctgaaaatt cttactctca gcttgggtca 255180 atgaaatatg acatataaaa ctgggaatta tttcattttt tattcaagtc tgtcttttta 255240 aaaattaatg ctttatactg ttgtgtctat ttatactaga tagaaactat catttggtta 255300 tataagatat tttagaaatg ctttatcaat cattatcaga agattaattt aaattttatt 255360 tcctttcaaa atctctgtat tattagaata aaaatctata catgattaga tgtatcccag 255420 tttggaaaga ttaggtcttt agatatacta catttttaaa acttgcacat gttccatttt 255480 attacatttt attgaacaga cacaagtatt caactgttgc tttctgcaaa taaatttgct 255540 agttgtgggg cagaagaagt gagacggaag agacacaaag atgaataaaa agatcctggc 255600 agaaaaagtt tacaactgca gcagaaagat ctaagcacac aaaaaatgca aagatgatag 255660 gaaaacagaa atcaagaaac gtatgggttt cagagtagtc ctatttacgt ttccaaatta 255720 accactttta aatcccctgg ttgaggagaa caaggtgaga ggggaaacat caaggagaga 255780 gcccacaccc agcagttcca tccacatcat ctgggaactc ggaacccagg ccggctgcag 255840 gagcctattc tctactcttg cccagaagtg aagtgttgat tagtattcag ttacactctg 255900 acagcacatc tttttacaaa gcattttcat aaacacccat attctcagta agtcctacaa 255960 aacttggtga gacaggtaga gctcttgctt tacagactaa aaaaaaaaaa aaaagctggg 256020 gattgaatca gggaaagtga cttgcccaga gctaaaaaaa aaaaaaaaat taaaaggaga 256080 atgaattagg acaaaactta ggcctcatgc tcatcccatg acttctttct ttctacatgg 256140 agtaagttta agttagaagc ataattagtg gggaaaagca taatcttgca acagcagtgc 256200 ctctgagctc taatgctgtg taaacttgag atctagattc cccagttgta ataggttccc 256260 agtgatgtga tgtatgtaaa gactaaaggg tgagttctcc ctggcatagc ttctcaaata 256320 cttccacccc aaccttccat agctttagga tttatacctc accgtcaatg ttccctgttt 256380 tgtaacaaga ttcttttgat atttcaagag ctaaaccact ttaggtggta cctggggtcc 256440 accttcttgg ctcccaagtt tgagatatta tcccaatttg agatattggt acatttctca 256500 gactaatatc tgaggttctt gaaagttcaa ggacatattc ttggggatta gataatgctc 256560 tataataatt atttaaccat attgaaactg cgaataaaaa taaaatggaa atggacataa 256620 gatatagatg atgtttccct cccatgagaa tttcacaagt ttgggtgtgt gaaaggatgt 256680 aaaacaaaat gtaaattaca tcatcaaaca gcatatggta ttagaggcct atacacctgt 256740 atccacagtt ctaaatgcaa taagtagttt taaaatgcag taagcatgta tttaagtaag 256800 agcaattcca catgcagtaa gtaactataa atgcaaggtg tgacctgtat ggacataaaa 256860 ttatttacag cttttatcta tatattttac tatgaacatg tatacattca tatattttga 256920 tgcatagata tcaatgtgct tgattattgg gtactgccct ttctaaaatc tgaaagcctt 256980 tcaaatctga aatagatctt gccccaatgt ttttagaaga tatgtataga cccatatagg 257040 tgtgattact acaaaataat ctgcatcagt ggccagtgcc ctgtttgctc ttttaaggac 257100 agctttatga agacattagt gccctattct tactgctggt gttttttcca gccaggtaac 257160 accaatcata atattaaata ctgttactca tttccattgt gtggtttttg ttgtattaaa 257220 tttgtaaatg cattaggatt ataaatctgt taggaactgt gaacatttga aattaattct 257280 gaattttgtc ttttcacata ttttacatac ttttacagta aaattattat aggtcagcac 257340 tggaagaatt tggagttttt ttccttgctt gtttaaaaat agatgtatta gtcgtattta 257400 agaaactttc tttaccatta tacttaataa ctgaaacaag gataacaatg tgatagttta 257460 gtgaatttca acttgtttaa gctttgttat attgacaaaa taaccctgga gaaaatgtaa 257520 ttatatagta aaagatgact gtgatatcct gctgtgtatc aggaagaaca atttttacta 257580 cttgtacatg ctctgaaagt atgtctaaat tttcctcttt atggaaagca tgatgaaaat 257640 ctcagtctcc ttactattgg aaatctgtat cttctcttgc tactaaccat ctgctcacct 257700 acctgaagta tctgtagatt ctgataaata aaaatttccc taaatatatc ataaccaatt 257760 acagtttaca gctattagtc aggcagactt gtttaaatag tggggggttt ttaaagcttc 257820 aaaaatacaa ccagggatgc aattttgaaa tttagcattt accacagaag ttgcctccat 257880 tgtttatgct aaaagtagat ttaaaatgtc tcactctcac taagcaacta aaatataacg 257940 tttaaaatgc tactcagcgt gggaagattt atgagcaagc aattatatca aactctcatt 258000 tgtttctgat tttactttct agatacaggt gtcctctaat atccaaatca atgatcatag 258060 aaaaatcagg tttaatctcc ttatctgggt aggaaagtga ggttggagag gtttcctagg 258120 ttgtggaaga tcacacagct aattagtgtc agagtcagtt ctcttcctcc cagtccaatt 258180 gtttgaacag ttttgttgtc acttgaaatg ctgtgttgta gatctaaaga taatgtgacc 258240 ttatctgccc caaagtttgc aaatcaatcg tctcacagtg ccaaggcaaa tagggcaagc 258300 ccagggacaa acagcatgac tcagccaggc ccccttcagc agggctggct tcaaagctga 258360 gtcatgaaaa attagattgc agagtcaaag cgctgtatgt tcccggcctt gtcctacaac 258420 taaaagggca gaaagtctca accgagtcat ggaataggag agtttctgta aggaaacttt 258480 ctgccagttc taaagtggtt attttgtgtt ttatcgctgc tactccttac tactaaaggg 258540 ttaaatgcta gaatatcact ccatataaaa gagtatggga taatgtctcc tgggtttatt 258600 tatatcttaa tgaaggactc cagaaaaccc tcttcaatcc taagaaagaa tagccggttg 258660 tgattaatgt ttttgggcag caaatctcag cttaacatca cccaaaacca aactaggtgg 258720 acagctaagt ccaaatggag tcttacatcc tattccagca ggggtaatct tgacctttta 258780 gaatcacctc tctttaaatc tcagactgca cggggaagta ttgttcagcc atgcttatcc 258840 agccctgtct aaatcgcact tcagtttatc cagcctattt tgctttgcaa gctggcttgt 258900 gcttggagat ctccccaggt cttcctgcag acactgagct tatcatcttc aaatgagaag 258960 tttgaggggg agtgcaactc agcagtttat ccttttaaca tgagtatctc atcactactt 259020 tttctttctt tgggtgggtg ggtccctttg tagcaacaag atttcaggca tctttctgga 259080 ttattgcagt tttcttaact gtaaatcaaa ccaattttca ataaagtaag atatatgaca 259140 ttgtcatttt actcctggca tttgatatca catttttccc aataagtgca aatattaccc 259200 aatgaaatag atattaattt tcagtcagtc tagtgaccta acaggataac attatataaa 259260 aacgtttgca tcttgggtaa gaaaatctgc atttaaatac acttttaaaa aaaaatctta 259320 aaagaattgc agttaaacaa ggtaattttc catggttaga aaggacaagc aggtgatata 259380 acctccaatg cctcttttta taataaggta ataagctctc acctccaaac gaatgtgccc 259440 caaatacctt ggtaacggat ataataaaac aatgactcta ttcttgctca gctgttatag 259500 tagtgattgt tgtattgttt agccattcat atatttcatg cagttctgaa aatagctatc 259560 cattgttgtt tgatttatta aattttgttc catcacttac ggatacaaaa gtgcaattat 259620 tagcaaagta agttgtgcag tatgcaatgc tagtttttaa aatttgggtc tatctgccta 259680 ttggtttcag tctgtcacga ataaagaaag caaccactat tatttgaaat caaaatggaa 259740 attcttctgc tcagaaatca gggagatatc cagggatcta tcaaatttca gttgcgtgaa 259800 gcctgccacc attacccact atggccactt ccattcttca aaactttgga aaatcgtgtt 259860 gctgtatagc ctctctctga gttttaatta cggcaaagca atgccaataa atacttcatt 259920 gaccatcctt gtgtgcagct aatatatttt ttaaattcta ccacatttca aaatgttttg 259980 ttcatttcac tcctttctct atatcaccca gacctcttga catctgggga ctatttctat 260040 ctaggaatta tgaaggtttc tctctacatg ttcctcagtt cccacagggt tgctctcctt 260100 gagtttgtgc cctctatttc ctaccccaaa ccaagcactc ttctcaacct ccctgactct 260160 gctctgctaa aagaggttct ccagtgacat ctgttagggt gggattgttt gatctgttct 260220 tctctccagt cctctttctt ttaacccaaa taattaattg ctcatccagg acacatgata 260280 ttcagaggga acctcctttc tacaacaacc catgaagatc ttgtcatttt aaaatgttgg 260340 attgagttgc atcaaacaaa attgaagtga attaaattga cttgaatgcc acagaatgga 260400 ctaagtatta caaaattgag tggaataggg taattttgtg ctgtgtccct cctctttgaa 260460 gcctcccctg ttcatattct tatagtgagc ccaatgttta tttcttgagg tgataatttc 260520 ttccatgttt tggcttttat ttacacactt ttacttacaa aatgaatcat aaaatatatc 260580 ttcctgaagg atatgtactg gctctcattc atttcttgtt attttgtagg cactcagaaa 260640 aatctttttt cctttggtct gggaaccaac ttacatcatt tctaagtgat ggacgtgtgc 260700 tgtgaaccat aaataatgta aacaagttag cactgccaga ggacaagggt tcagttagaa 260760 agaccttcct gactgtgagc tatgatgcct ttagcacaag ctcaaaaagg tcatagagtt 260820 gcattctctg catattttcc agagaacagc ctggagtaca tgtgacctga tctatagtca 260880 agcccatttt gaatgaaggt agagaactac tataggaact agcaacagct attcaggagg 260940 gtgtcaccat tattttttcc aatccaagaa aacaagttat acttctccat taaaggtcat 261000 ttaaaaataa ttagcagagt atttccgaaa agagaaatca ttgcttctac gtaactcttc 261060 atccccacag ttccagttgt cagcctttct gagaaaaaaa aaagtgtttt ctatctttga 261120 ttactctatc tactctgtgc ctgtcttcgc tagggttcat cattaaacca actgcttctg 261180 ttgccattat aagaaatgta gactttcgga aaggcttgtt acatttcaga agtgcccacc 261240 ctgttcaata aatggtactt ttcatctgtc cccttttgct gcaggggcag tttatctgcc 261300 aatatccctg gaattgctcc ctgtttcact gcaccaagga tgagaggccc tacaggtttt 261360 tgtcctgaaa cccgtatgtc aaacactagg gaggttaacg agtctccaac ctactcactg 261420 aaactgagga aaacagaagt ttcatattga catagccgag gatcaagaag gacattacct 261480 ccttggaaaa gtgattacag tggctctttc catacacttc catcagccaa gatgtgctgc 261540 atctccctct acaggaacca aagctgaata agcctgcatc ttactgacgt tccttttcta 261600 tttcccggga gagactaaaa agtggctcag cctacaaggg agccaaggga ccactttagc 261660 atgaccctga ttcttgagga gagacgagct tcatatgcag gtgcagtgaa gtctcccttc 261720 tggccccatt ctctgctcag tcgatacaag taagagatgc cttggcttgc tgctcaaatt 261780 atttatatga ctcaaggatc cacagagccc tcataagcct cataaatgag ctcagaaaaa 261840 aaactgacac atttttcttc atgctaagcc tgaatttcac taacacatag gattatttta 261900 tgatccaatc agtccaagtg taggcgtttc agtagatgcg tagacataac atacaattga 261960 tttccttgcc acagattaaa aaaaaaaact cataaatctg aatgaaaact aatttttgat 262020 tttagtagaa ctgaaaataa taataataat attggtaaca atgattacaa tttggtagga 262080 ttttcctcat aagatgttca ttttcccaat gatagcaaag gatgcttatc aagggaaata 262140 ggtcccactt ctacactcag gaattacttt tctcctttgc atttgtaaat ggatataccc 262200 aaaacttcag ttcctatgcc acgaataagc atgatctctc caagtgccac cttccagtta 262260 gcccagggcg aaacactaaa gtggacaaag tactccagtt ttctgttttt ctttttcact 262320 gtcatctaag cttcagccct ggcttcctaa gtttccagtg tcatgctcta ccctcatctg 262380 ccctgcttga gcactgaact gaccttcata gaacagtgag cccaaagctt agggtcagaa 262440 gccttggccg tgtcactagc tggtttgtca tgctttagat gtgtcaccgg tttctctcta 262500 tggagtggaa ataatatcta ctttaccagg acatgataag gactgacatt atatatgtgg 262560 aaacatgttt gaaagccgta aagcacaaaa taaatataaa tatttaaaca ccctgaaata 262620 acttatgcta aatgcctggt tcaatagata tgaatttgct aaaaaattat ttttcataaa 262680 tgttactttc atttccccct ctttggtatt gtctcagcta gcgttgaagg acccactgtc 262740 tctctcacat tagaaacaat ttctgtgtaa aacatcccaa atcactaagg gcacatttga 262800 ctcatgtatg cattgtagcc taggggcttg tctccatagt ccttggaatc caatactagt 262860 ggaaggatca tggattttgg aattaggcat actcagaatt acatctcagc tcagtcactt 262920 agaaattcta tgaccttggg caggtaactt aatctcctta ggctccgttt cttcaactat 262980 aaaacggaaa tagcaatgcc tatgtagaag gagcctgaca ctagtaaata taaatatata 263040 aaatagtttt cattcattta atttggaact tgtggaaaat tctatcaaac aatagtcttg 263100 taaataaaac tgtgcttagt gtggagtaag caagttcact ctatggagaa aaaaataaat 263160 gaagtgattt tatgttgacg tagtcttttg aagtttgtga agtactctcc cttgaatctt 263220 cctcatctag tttggtatga ctctgtgagg aaaggaacag gttgtattct ctcagttatg 263280 cagaagtaac tgaaattaga ttatgtgcct tggctaaagt tgcagaagaa aatcatagga 263340 atggggaagc taagtctggt gctaagagcc tcaaattaaa taattttgtt ccaagatctt 263400 ccattatttt ctcaattaaa ggccagtttc tgtaacgagt ttccaaatct ctctgggttc 263460 ctcaatagat gatttccttg attttttccc ctacctatga atagatagat agatagatgg 263520 atagatagat agatagatag atagatagat agatagatag gatggataga tgatagatag 263580 atagatagat agatagatag atagatagat agatagatag acagatagat ctatctgtta 263640 atgctttgat gtggccttaa gtgagggaga gtaaagagag aaatttcagg gaaagctggg 263700 tgtgttgact catgcctgta atcccagcac tttcagaggc caatgcagga ggattacttg 263760 aggccagaag ttcaggaaca gcctgaacaa cagagcaaga cccaatttct acaaaaaaaa 263820 aattttttaa ttatactggg catggtggtg tgcacctata gtcccagcta ctcagaagat 263880 tgaggcaaga ggatggatca cttgagccca agagttcaag cctgcagtga gctatgatca 263940 ctccactgta ctccagcccg ggcaacagag caagatcctg tctccaataa ataaataaat 264000 aaataaagaa gaaaaagaat agaaattgca ggaagagttt ataataaagt accctagttg 264060 aaagagtttc tgttcttcat agttctacca gatctaatta aaaacttacc tttcctttct 264120 ttctgtcacc tctcttctcc tcacttcttt cttttattac aagacccttg gtcatcatta 264180 gagtctttgc tagctctaaa agtgtatgtt ttaccacttg ttttcgttgt accctcttgt 264240 aaacaggaaa aaaaaacccc aaaaaaccca aaacactaga aatatttttg tggttgaggt 264300 ggactctttt gagggggaaa agtgtgagaa acatagagga aaaatagatt taaatgagag 264360 caaatgttaa gattaggtaa aaaggaagga gtactaattt cattagctgt ctcaagtttt 264420 ctgccttaaa agaaaacatt ccattaagga ataggtccaa ttccaagtat ttctccaact 264480 ttttaaatct tggcatagta gaattgggag acatttcatc tccttccttc tcactatccc 264540 caaaactctg attttacaga tgagaaaatg aaagctagaa aggtgatatg accggcaaag 264600 ttgcagagaa gttaagagag ctgcaattat tcttgtcttt tgaatcacga ctttctaatt 264660 tttagcctca aatagtgtca aagaaaaaaa gtttaacaaa ccaaatgtta gtaaaatcac 264720 agttagaaaa tttatgagag gatttgaatt cttcacatca attaaaaata aatacaagtt 264780 acttggtatg cagccatgat cttgctttat gcaaagatta gatgttgcta ttaaaaaaat 264840 gcacttttgc caaattcaga cctcttcaat actcatgggt tcacttctaa atcaaaccca 264900 aattatgtgg ttctcaaagt tgtatatgga aaaaccccat tttcttcaag tgagtcagct 264960 gtctgaaaga ttgtttataa tgtttccagg actgaaataa taaactgttt ggtttaattt 265020 tacagctaca tggcaaactg cgaaattaaa ttgcaaaatg tctctgtgag ctaattttaa 265080 atttttaaaa ctaatctaca actgacataa acataatccc cttagttcca aggcaattat 265140 agtttttctg gttaattcac aaatagatgc tgttgttttg aaaaggcaat gcagttacat 265200 gcagaagaac tgagcagata atagtggcca gaacctgaaa ttttatgttc cgtgggaaag 265260 tcagtctcta gggttatcaa gtgcagctgt tggtgctggt agaaatataa catagtagga 265320 tataacattc aggaaacatg ggggtaaaca agagccagct agccaggaca gcatttgaaa 265380 ttgggagatc caatagaagt taagggggtg actcaactgg cagcatagca gagtgtcagg 265440 aattgcggca ggcaggtggg aagggagccc catgcaaatc tgtatacagg taacagagtc 265500 ccagacttta gaaagaggca gactaaagtc ccctgtgaaa gaatattcta gaggatcaag 265560 ttccaaggct gggattcaga caagaaagcc agagtagggt aaatgcggga agagaaccat 265620 gattgaggaa taaggcagaa ggccaattat tctacttgat ctacaaggtc agggtcaaac 265680 tagcagcaga tgtgatttga tcctgtgtcc ccaaatagaa ggctttacac gctctcaacc 265740 ctcccatgca tggtcaaatt cccagttcta gatcccggct cagcctgcct gccaagtgac 265800 ttagctagag aagagggggt tggggctgtg cagaggcaag acctggtatg aattctttaa 265860 tttttccaca attactgaaa cattgaagga gtaaaagcct cacatgccca acacttccac 265920 tagcatttga taccatatgc caaggatagc tcatacaata tttagtattc tcatctacct 265980 gagcatttag cattccacct gaaatacatg tgatcataag aagcaacaat agttaatgtt 266040 tgacttttgt tacacaacct gataatactg tgtagaggaa agaatgtgca actgaatctc 266100 caaaggcaac ctttgtgtca tgggcctgct gggactgact gtggcttctc tgccaccacc 266160 cagctttgct cttgtcatgt gtagtctggc acgatgagct cacaggctcc tttcacctcc 266220 agctttctaa atttttattc caaactccaa gggatgaaca ctactaaaga acccatggga 266280 ttgttcttct agaaagtgcc agtggcattc ataacattga atacttacat gaaaacccaa 266340 aaactcttgg ctctaagcag tttcagaaag taattacagt ctattaagta aatagcttac 266400 attttcaagt gcacttatgc aactgtatta agagaccata ataaacaact attaccattc 266460 tattgagcca actaacaggt atataattga gtttttgttc ttctcttttt ttttttacaa 266520 agaagagaaa attaatactt taaaaaatac taaagtttga aagagactat taaagcccta 266580 aaataatgag ttgagacagg cttgtctgtc aacttgaaga atggctaatg aaaagtcaga 266640 atgtacagcc caagttctcc ccaagccgtc acatttggca ttgtattaaa catttatgtt 266700 tattaatctt cagtgcacag tatgtacttt gcagtgtcca gtgacaaata taaacatcca 266760 tgccttagag atgcaaaata cacctatgtt gtataaattt gttcaatgga tattcagtga 266820 attatgtgat tttagatcat taaatactaa tatttaacac aaatttcaaa ctctaaaaaa 266880 ttacctactt aaaagatttg atgataattt ggataaatta agaattatga ttcaaaattt 266940 gtttattctg ttctttttat aacatattcg tgatttttat agcaacccgt cctcacaggc 267000 attttttttc ctggtaacta tatgccacaa tgtccttgca taggtattaa actgtgattc 267060 aaatatctct gcattttcct taaaaagttg aaaattagaa gctccctgcc agttgaatgt 267120 ataataatat tttgtaaagc agtcaagtat accatattga acataacaac atgttggata 267180 aattttccaa agcagtacct agaataattt tgttaaatta ttgttaaata atttcttaat 267240 ttagatgtat gcaacataaa cacacacaca aaaaaggtgg ccgaaatact tttgcctacc 267300 tggtggacta aagaaaataa taatgttctc tacaggtata ttaaaataat acatatctta 267360 tgaatctgct aaatatgtaa ttaataaact ctttgtaaat ttccaagcaa tggaattgca 267420 tagcttgcta ttttctaagg tatgtcagct taaatcttta tgcctgatct tcgtttattt 267480 taattatgct attagtatta cttttattac atcaaacttt ttattcattt ttgtatatct 267540 ttcatcagga aatgtttaat agtttctctt cttcagccct tgagtggtta gacactgtca 267600 tattaaagaa tgagctacta ttcttaccct tgatgttctc acactcagtc atggcttgat 267660 tttgtaattc ctccatctct tatcataatt tcccttttga cttttctaca catgatccta 267720 tttacatttt taagttaatt tgcataaagt ttttcctgca catttcacaa catttcttga 267780 ggaattcatt tcagggtata ttgagatcaa gtataaaaat tattaggcca tatttgtaat 267840 ttcatgacct ttttttttaa gtgtgttatt attatacttt aagtttaagg gtacatgagc 267900 acaatgtgca ggttagttac atatgtatac atgtgccatg ctggtgcact gcacccacta 267960 actcgtcatc tagcattagg tatatctccc aatgctatcc ctccgccctt ctcccacccc 268020 acaacagtcc ccagagtgtg atgttcccat tccggtgtcc atgtgttctc agtgttcaat 268080 tcccacctat gagtgagaat atgcggtgtt tggttttttg ttcttgtggt agtttactga 268140 gaatgatgat ttccaatttc atccatgtcc ctacaaagga cgtgaactca tcatttttta 268200 tggctgcata gtattccatg gtgtatatgt gccacatttt cttaatccag tctatcattg 268260 ttggacattt gggttggttc caagtctttg ctattgtgaa taatgccgca ataaacatac 268320 atgtgcatgt gtctttatag cagcatgatt tatagtcctt tgggtatata cccagtaatg 268380 ggatggctgg gtcaaatggt atttctggtt ctagatccct gaggaatcgc cacactgact 268440 tccacaatgg ttgaactagt ttacagtccc accaacagtg taaaagtgtt cctatttctc 268500 cacatcctct ccagcacctg ttgtttcctg actttttaat gatcgccatt ctaaatggtg 268560 tgagatggta tctcattgtg gttttgattt gcatttctct gatggccagt gatgatgagc 268620 attttttcat gtgttttttg gctgcataaa tgtcttcctt tgagaagtgt ctgttcatgt 268680 ccttcaccca ctttttgatg gggttgttta tttttttctt gtaaatttgt tggagctcat 268740 tatagattct ggatattagc cctttgtcag atgagtaggt tgcgaaaatt ttctcccatt 268800 ttgtaggttg cctgttcacc ctgatggtag tttcttttgc tgtgcagaag ctctttactt 268860 taattagatc ccatttgtca attttgtctt ttgttgccat tgcttttggt gttttagaca 268920 tgaagtcctt gcccatgcgt atgtcctgaa tggtaatgcc taggttttct tctagggttt 268980 ttatgatttt aggtctaacg tttaagtctt taatctatct tgaattgatt tttgtataag 269040 gtgtaaggaa gggatccagt ttcagctttc tacatatggc tagccagttt tcccagcacc 269100 atgtattaaa tagggaatcc tttccccatt gcttgttttt ctcaggtttg tcaaagatca 269160 gatagttgta gataagtggc gttatttctg agggctctgt tctgttccat tgatctatat 269220 ctctgttttg gtaccagtac catgctgttt tggttactgt agccttgtag tatagtttga 269280 agtcaggtag ggtgatgcct ccagctttgt tcttttggct taggattgac ttggcgatgc 269340 aggctctttt ttggttccat atgaacttta aagtagtttt ttccaattct gtgaagaaag 269400 tcattggtag cttgatgggg atggcattga atctgtaaat taccttgggc agtatggcca 269460 ttttcatgat attgattctt cctacccatg agcatggaat gttcttccat ttgtttgtat 269520 cctcttttat ttcattgagc agtggtttgt agttctcctt gaagaggtcc ttcacatccc 269580 ttgtaagttg gattcccagg tatttaattc tctttgaagc aattgtgaat gggagtccac 269640 tcatgatttg gctctctgtt tgtctgttgt tggtgtataa aaatgcttgt gatttttgta 269700 cattgatttt gtatcgtgag actttctgaa gttgcttatc agctttagga gattttgggc 269760 tgagacaatg gggttttcta gatatacaat catgtcatct gcaaacaggg acaatttgac 269820 ttcctctttt cctaattgaa taccatttat ttccttctcc tgcctaattg ccctggccag 269880 aacttccaac actatgttga ataggagtga tgagagaggg catccctgtc ttgtgccagt 269940 tttcaaaggg aatgcttcca gtttttgccc attcagtatg atattggctg tgggtttgtc 270000 atagatacct cttattattt tgaaatacgg cccatcaata cctaatttat tgagagtttt 270060 tagcatgaag agttgttgaa ttttgtcaaa ggccttttct gcatctattg agataatcat 270120 gtggttttta tctttggttc tgtttatatg ctggattaca tttattgatt tgcatatatt 270180 gaaccagcct tgcatcccag ggatgaaaga gctcctgaag gaagcactaa acatggaaag 270240 gaacaaccga taccagccgc tgcaaaatca tgccaaaatg taaagaccat caagactagg 270300 aagaaactgc atcaactaac gagcaaaata accagctaac atcataatga caggatcaaa 270360 ttcacacata acaatattaa ctttaaatat aagtggacta aatgctccaa ttaaaagaca 270420 cagactggca aattggataa agagtcaaga cccatcagtg tgctgtattc aggaaaccca 270480 tctcatgtgc agagacacac ataggctcaa aataaaagga tggaggaaga tctaccaagc 270540 aaatggaaaa caaaaaaagg caagggttgc aatcctagtc tctgataaaa cagactttaa 270600 accaacaaag atcaaaagaa acaaagaagg ccattacata atggtaaagg gatcaattca 270660 acaagaagag ctaactatcc taaatatata tgcacccaat acaggagcac ctagattcat 270720 aaagcaagtc ctgagagacc tacaaagaga cttagactcc cacacattaa taatgggaga 270780 ctttaagacc ccactatcaa cattagacag atcaacgaga cagaaagtca acaaggttac 270840 ccaggaattg aactcagctc tgcaccaagc agacctaata gacatctaca gaactctcca 270900 ccccaaatca acagaatata catttttttc agcaccacac cacacctatt ccaaaattga 270960 ccacatactt ggaagtaaag ctctcctcag caaatgtaaa agaacagaaa ttataacaaa 271020 ctatctctca gaccacagtg caatgaaact agaactcagg attaagaatc tcactcaaaa 271080 ccactcaact acatggacac tgaacaacct gctcctgaat gactactggg tacataacga 271140 aatgaaggca gaaataaaga tgttctttga aaccaacgag agcaaagaca gaacatacca 271200 gaatctatgg gatgcattca aagcaatgtg cagagggaaa tttatagcac taaatgccca 271260 caagagaaag caggaaagat ccaaaattga caccctaaca tcacaattaa aagaactaga 271320 aaagcaagag caaacacatt caaaagctag cagaaggcaa gaaataacta aaatcagagc 271380 agaactgaag gaaatagaga cacaaaaaac ccttcaaaaa attaatgaat ccaggagctg 271440 gttttttgaa aggatcaaca aaattgatag accgctagca agactaataa agaaaaaaag 271500 agagaagaat caaatagacg caataaaaaa tgataaagag gatatcacca ccgatcccac 271560 agaaatacaa actaccatca gagaatacta caaacacctc tatgcaaata aactagaaaa 271620 tctagaagaa atggataaat tcctccacac atacactctc ccaagactaa accaggaaga 271680 agttgaatct ctgaatagac caataacagg agctgaaatt gtggcaataa tcaatagctt 271740 accaaccaaa aagagtccag gaccagatgg attcacagcc gaattctacc agaggtgcaa 271800 ggaggaactg gtaccattcc ttctgaaact attccaatca atagaaaaag agggaatcct 271860 ccctaactca ttttatgaga ccagcatcat cctgatacca aagccgggca gagacacaac 271920 caaaaaagag aattttagac caatatccca atatccttga tgaacattga tgcaaaaatc 271980 ctcaataaaa tactggcaaa ccgaatccag cagcacatca aaaggcttat ccaccatgac 272040 cattttttac agaatgcaaa gtcatagcat cttttaaaat tatttatgtc atacatttat 272100 gttatacatg caatatctga gaaaaaatat gaagttacta tataaagctt aaaaagtttg 272160 cattcttttt gctagacctc tagctagact tctttctttt atatatttct tatatatatt 272220 ttgtatttcc tctttgtttc tactccaaca gctttaactt catcctttga ttcataaata 272280 ccattggctg ctggtcatgc aattcaacaa gaaatgttta acaaagaaaa aaatgtgtat 272340 taatatgtca ctcaacttta cctcatttta atatttgtat atttaatcaa ctggaaataa 272400 aaattgtaca aattacagtc acacattgct taattatgag gatattttct gagaaaatgt 272460 gtcattaggt gatttcatcc aaatgcaaat attgcagagt atacttacac aaatctagaa 272520 ggtacagcct actatacacc taagctgtat ggtgtcgctc ttacattaca aacctgtaca 272580 gcatgttact ctactgatat ggtttggctt tatgtctgta cccaaatctc atcttgaatt 272640 gtaatcccat aatctctatg tgtcaaggga gggaccctgg gggagctaat tgaatcatgg 272700 gggtggttcc ccccatgttg ttctcgtgat agtgagtgag tcacacagga tctgatggct 272760 ttatgagagt ctggcatttt ctctgcttgc attcattcct tcttctgctg ccatgtgaag 272820 aaggacatgt ttgctccact ttccaccatg attgttaagt ttcctgaggc catgctgaac 272880 tgtgagtcaa ttaaaacttt ttaatttata aattacccag gctcaggtat gtctttatta 272940 gcaacgtgag aatggactaa tacatcttct gcatactgta tgtaattgta aaacaatggt 273000 aagtatttgt ctatctaaac atagaaaatg tgcattaaaa atatggtatt ataatcttat 273060 gggaccacca tcctacatat agtctttcat tgatggaaac attggtatgt ggggtattta 273120 acacctttaa ggtcttaaaa taaattactc attgtttcat acatacattt gtattatcca 273180 aattattctt gttatttgaa aattatttat tgagcactta ctgtgtgcca ggcactattc 273240 tagccagtga ataaaacagg ggaaaagtac tcttataaag cctgcagtct agaaaagaaa 273300 gataaacaat acaaatcaat atacaaaaca tataaggtat atgcttttat atcatttcct 273360 gccataatca cttggatgct ctactgaagc catacttgct tttttactgt ggggggaaaa 273420 atgcaaattg aaaatgactt gccacccatg aagcacactt cctagcaagg gtacagaaaa 273480 tcaacatgta tgatagtggt aacatccgct attctcactt ttactcaact ccaaccccca 273540 atttcgtatg agtgtttacc cttgttagcc ctcaccaaaa ggcttttgga ctgttatttt 273600 cctgaaagga aggcaggaag aaaagagagt aaaaaagagg gatctctttt gttcttaatg 273660 ctttgtaaat tttgattttt tattagaggg tcatttagaa gatagagtat aaagagttat 273720 gttggaatat catatctact aaagtgatca ttttataatt atcatcttct ttctgctaaa 273780 taatgaccat attcatattt attccaatat tgtctttgga gaaaactcaa caatgatatc 273840 ttcttacttt ttcagttgtc ttattttctt gtatgtgttg agttcatgcc atatacaggt 273900 atactaacag gcctgccttt cttcagtgaa aaattgcact gttgtcatgt attaatagac 273960 tttatccttt gaatacatga atccttccat cccacccagc tgatcaaatc ctactatttt 274020 tttaagacta ggctcgactg acaatcaccc atccaggtgg aatggtttca cttttccttt 274080 ggatactcct gtgttcagta tataattttc tcatagctgc tgatacaaaa atctgatatt 274140 tagctattta caaatcttga tctctacctg accataacct ttgctaatca gaatgtcaga 274200 atggaagccc tacaatggca attactctgt cttgtctttg tagcttcaag caaaaactac 274260 ctggtcttta ctgggtactt aataaatgtg gtctttatta ggtacttaat aagtgttttc 274320 tgattaaatg aataatgaat caatgaataa atgttgtcta catgagatgg taaattgact 274380 atcttttatt tttccctctt gcacttaatg atcatatttt caagacaact cacttgattt 274440 aagcaggtag tttgtgattg caggatagac cacatggaac tgagtctgtg agctcagtct 274500 cattctaaca ttgttataaa taaatgagct gtacatggtt acaaagcatt tattgaacac 274560 ttgcgagtcc caaaatatta tgctatcccc aaataatatt ggattgaaaa gcgaccatgc 274620 tttacacaaa aacagatttt ataaaagatg ttaagcccag gtaagtgtct tggctatgag 274680 gctggtaaac tccatgaatg atgatggaaa ggagaagcac agaataataa acaacagatg 274740 cttttttttg aggaggagga aagggttggt gctggtagat tccccaaaag gcagcggcct 274800 cttaggtgaa tatcttttga aaactttcag tcccccacta tgagcattaa agtggcaggt 274860 catggttccc agatagatga aaggaacttg taagatatct taaaacataa aataatatgt 274920 tcatatttat taagtattta gcatacaaag taccttatag ctattatact ctttatcttc 274980 acagaaaacc cctttgtcat cattgtgttt tatggatgaa aaaacaaaag gtcagtaatt 275040 tgtccaaggt cacatacttc aaagtaaagt taatatttga atgcaagcac acttatacca 275100 agttgttagt acattcctag ccactaactt gctctcaaaa tatatcagga aaatttttca 275160 gatggtgaaa ctttataaat aaagtttata aatagtttat aaatcaataa accgtataaa 275220 taatcttggg agaccaagag ctgacatcag actcacaatg tccttgtatg tatttaacga 275280 tggaaacaag tcttcatttt atagcatcag gataactaag caccattcaa caagtgacta 275340 tttaatggga cattttgaga tctttcatac agaaaaataa tgctgacttt ttctttccat 275400 cttattttac cattcagtaa aaactgtcat cctttggtac ttcttatcta gatatttttg 275460 tatgccccta atttgcccaa tatttatgtg taaaatatat gttccagtaa gagtatatac 275520 taaataatta gaatttattt aaatagatta tgttatctaa cttacgtaaa tggagatttt 275580 cctaggacta gttacgtttt ttttcctcaa gcaaaatact gtatttgcat tgttgctaaa 275640 caagtgatga tcaggaaata aatattttat gttaatcaag tctaaatgtt gtgtaaaaaa 275700 tacctatatg gggaagaaaa aggcatacca tggcaactga agaaggttga aaataattac 275760 tccttcctag ggacaatatt cagactcagt agcaggcatt ttgccagccc agcagataga 275820 catattgaag cccctacttg ttggtatgaa atattaatag tgagggcatg agtccaacct 275880 gaaaacataa aaacaaatta ctttggaggt taaggggata taccattact aatccatctc 275940 tgagctgaat tagcctttaa atataaaaat ggctcccaat aacatgtcta gcccaacatt 276000 agagttattt ttaaccaagt ggggttttgg agagactata aaaaattatg attttccaag 276060 ttcatgaaat gtgaaataag cagtttgatg cagaagaaga tatagtgaca cgaatatgct 276120 aaaagtgaac agaatgcgga tctagccttt aatgaacttt agaggtagaa ccatgtagta 276180 attttacaga tgcaaaaata ttatgttgta cctccttaat cctaaaccaa taatccttct 276240 catccttgat gttacaaaga attagtggtc aaggtcatgc ataaaatgtt ctgcaatgtg 276300 ggaaaataat aagggaaaat aacctgtata aatgtctcta aatttaccac agagagtctt 276360 cccaaggttt tccaagaaag aaaagcagaa cagatcaatt atataagcaa ttttacgggt 276420 tagtgaagta tctttcacct ctctggaccc caatttcctc agggggatgt ggcttgcttt 276480 acgttgacag aggtaagaag attcattgag aagaattctg caaatgtaac attccctttc 276540 aaggtctacg ctaacgcttt taactgggac tcagcgacct gtgaaatctc tgcctggttt 276600 cttaaccttt gtcaagtcat ttaaactctc tgggtcatat ctataaatca gacagaagaa 276660 atacaggtcc taaccgtgct atccagggat tctagcagga gattttttta ataataaata 276720 ttaatggagg ggtggaaata gagatggaaa aacaggatca aaggagcaac atattcagtg 276780 acttaaaaaa ataattatat gtggtaagaa gttttctaaa gtaaactgta tgtggggaga 276840 agcatacaga aaaaaatgaa atacatatat tttaaggttt gaaagaaaat aattttgaat 276900 tgtacccgtt tattgctatt aaagaatgaa tgaccaatga agacattatt gtagataaca 276960 actttttaag cccctgagaa gaagagctgt gagttttatt gggaaaatat atttcttaaa 277020 taacgccaca ataaatcatt gctgtacaca ccaggtgcaa ggaaatgcta aggagaaaga 277080 gaaagaacta gaaattaatg ttctttgtaa gatgacagat tgtcagattt agatgctgtc 277140 tatacctaaa ggagacaatg ccatgaagtc acttcttaat atctagtagg atttcatttt 277200 agaactaatt acatgctttc acccaacagc caacatgctg tgttagtttt cttagtttac 277260 actttgtaaa ttttgagctc agttttcact tctattttta aagattagta ggtaagtagt 277320 catatttgac aattcaaggt cacaacacaa gaaattgaat atttgcaaag gcattcttta 277380 tctgataggc ttgcaccctt tcactctaga ttattataag ctagaaaaag aataatcact 277440 ttgtgttcta agccatgcaa gcaaaaccac cactgagaag gatgtgtgtg cctctgtgtg 277500 tgtatgtgta tgtaaattcc tatattgtgt taatcaagaa atacaataca aggtaaagta 277560 attaaaatgt aactgcttgc ttatcttaaa acccttatca gttgctgctt actaaatggt 277620 acgatctatg tgtctagtgc tcttgtataa gccattatat gatttcatgc tgaaaacccc 277680 caacaaggga gttagaatta attgagtagt cagatgaaga aagcagattt cctcagttag 277740 tagatggcag agctcaaact caagcccttg gccattgtcc ttgcctggga ggtacttatc 277800 actgcacatt taaactcagt gaatgtgcca tctttcactt agtggcagtg cttaaattac 277860 aagtgtcaaa aataattacc ctatgaaaag tgaccctgtg tttctgagtc agctaagaga 277920 tggtttgaag aaagaccaat atcctaccct catcctcgaa ctatggcaaa agtgataggt 277980 tctccatcag agcaagcatt cttctttcct gtaactgcca ctttcacact gggctatggg 278040 acgcaagtgt ggcacccaat acaaaagatg gattctagaa ggaatgagtt tatgctagat 278100 catttaaacc acacctttct aaaagcccag gaatagcaag atgggcaaga caaagaaagt 278160 aacagacatt gaagagctgg tttgcaagat tccatcgctt tattgactgg caagctgctt 278220 ctctttggtg gaagccaccc ttctcctacc tcctgtcaac accctcagct tcctcaaagc 278280 ccaggtccaa gtgagcagga cccagtgaga ggcaagttca cctcccatgc tcagtcgtct 278340 gagctaagga ccgagtactt ttacctgagc ggtcaacagc aagaatatct actctcttat 278400 actttacttt tgctacagca tcttggactc accccaaagc cacggtgcaa ctagttcaga 278460 acaggacaca ggatgcccaa cctccatatt agggatctgc acagtgttca cagtggcata 278520 tacacagaca gaaggagccg tcaagcccac atccttacaa ctaaagcctg tctcaattac 278580 ctaactttta aattatgtat gaacaccatt ttaataaaaa tcattcatat tatacatcaa 278640 ccatcaattt ttattaaaaa gtgatgtgaa atttgtatct tgcaaaacaa agggaaagtt 278700 tacttttttt aaaattatac tttaagttat ggggtacata tgcagaacat gcaggttttg 278760 ttacataggt atacatgtgc catggtggtt tgctgcaccc atcaacccgt catcttcatt 278820 aggtatttct cctaatgcta tccgtcccct agcccccgac cacccaacag gccccggtgt 278880 gtgatgatcc ccctcccctg tgtccatgtg ttctcattga tcgactccca ctcatgagtg 278940 agaacatgtg gtgtttggtt ttctgttctt gtgttagttt gctgacaagg atggtttcca 279000 gtgtcatcca tgtccctgca aaggacacaa actcatcctt tttatggctg catagtattc 279060 catggtgtat atatgccaca ttttctttat tcggtctatc actgatgggc atttgggttg 279120 gttccaagtc tttgctactg tgaacaatgc tgcagtaaac atacgtgtgc atgtgtcttt 279180 atagtagaat gccatcggaa agtgggcaaa ggatatgaac agacacttct caaaagaaga 279240 catttatgca accaacgaac atatgaaaaa aagctcatca tcactggtca ttagagaaat 279300 ccaaatcaaa accacaatag ataccatctc atgccagcta gaatggcaat cattaaaaag 279360 tcaggaaaca agagatgctg gagaggatgt ggagaaatag gaatgctttt acactgttgg 279420 tgggagtgtg aattagttca accattgtgg aagacagtgt ggcgattcct caagaatcta 279480 gaactagaaa taccatttga cccagcaatc ccattcctgg gtatataccc aaaggattat 279540 aaattattct actagaaagt ttacattttc acttaaaaaa ctggtttaaa gaaaatgaaa 279600 tgtcgattct tttcagcaac aacagcaact acgactgctt catagcaaaa gcaacagcca 279660 cagcaaaata gataaagaaa gaaaagagtt taaaggaaaa aaaggagcat atgcatcatg 279720 aatgttcaat ataaattaga tacataatta tgatcttgat agaatataaa caaaaatttc 279780 agatttcaga gaaatctact gagcaaaatt tttcatacta taaaatccaa cagtcagtaa 279840 aaacaacatt tccagatagt aaaaaaaaaa aaggttattt catttctgta ttttcaatat 279900 gaagctgtct aactactata gttccatata agaataattc cattttgaca tcagacaccc 279960 ttgtggacac taacatactg ggaaaatggc cttcatactt tgttatttca agaagagtga 280020 attatggaag aagccattgg ctaaagagtc accttttaaa gaatttgatt gcaaccccat 280080 taattttctg taactctgca atacttttaa atcgcaagta tttgtagtaa taaaattata 280140 tttattttga atatacagtt catgaaagca catcagttta tgaaagcaca tcagtttgat 280200 ctggtgctcc ttcaatttca gcatctgaag aatgatagag acattaaaac tataggttct 280260 aaaaattatc taattcattt tcatacttga ctggcatcac tcattcaaag acataaaact 280320 tttaaccttg actattgcac atagcctttt acacacaaaa tagacacaga attgggcatg 280380 atacattatc ttctgtccct ctgttccctt tttaaccctg gatgccagcc acccacctac 280440 ttgctctgat gtccagctgt ccccagccta gctaagtggg ctcttccctg tcagccacag 280500 actttcctct cctctgaaat gtccttgagt ctaggatggt gtgatacttt tgctcctgtt 280560 ccgatgttac agttagaagt tagccacttg ccaggaggta agaagagctt tttagcacag 280620 acatctctaa gtccagagcc ttacattcag gaaaaaaatt tgaaacggca gaaaaatgct 280680 tcagaaatat aacttccaga cacagaggaa aaacttgttt cctcggttaa taaattttgt 280740 ggcaatgcaa tttgacattt acttcattga attctgggaa catgatgttc tggctagttg 280800 ccacgcaaga attattcttg cagttggcat cctctctact tttcgaagtt tatcaccaaa 280860 gagagacagc ttcatcacag acaaacatat aggtcaagtt tatatgtcag caaataaata 280920 ttttggaaaa ctaatacgaa tgcccactgt ggttgttagt ttctaaaaat gagaacatgt 280980 tctaccccgt tttgttaccc agtaaatttt tgtgatacag ctatacattg taaactgtgc 281040 tcacataatt cagaactcca tctattaaat atttgtgaca aacatacttc aggcacacag 281100 ccacctcctc tctctttcca gtgttcacat agatacaact atagctcagg tatatagttc 281160 atccagacac atttttgtgg accaccttac cccatcaatg tgagatatca tttcactggt 281220 ctcagctctt ttcttgttac attctatatt cacatcttca gcttaagttg tgaagaggtt 281280 acaatgaagt gtgataaggg taatgatcaa aagaaccaat tagggaactt ggagataata 281340 taaaatgatc atgggtgtct tgtttgcatg ttttgaagtc atagaaatgg taaactaagg 281400 aagcccttgc ttttaagctt tctaaaataa aactgttttg caaataataa tattggtact 281460 aggattaata gtagaccttg aggtcatttg aggcagtttc tggcataatt taacaccttt 281520 atcactaatc ttgctgttac tgatcgcagc tgactctcac actgtttttt ctctgcatga 281580 tttattagaa ttctttgata agagctcttt gaacctggcc ttgtaattaa gagttcttta 281640 gaaattatct attattctgg agtatagttt ctcaaactct ctggcctcag attctacatc 281700 tgttaattga agaatctgaa tttgatgaat tctgcctaaa aacactgtag caatttttat 281760 catttacatt gaaaaataaa aactagatct aacttactcc atactctttc aactgcacca 281820 tattgttttt tgttttttgt ttttttgctt tttttttttt tttttttttt gaggcagagt 281880 cttgctctgt tgcccaggct ggactgcagt gacgcaatct tggctcactg caagctccac 281940 ctcccgggtt cacgccattc tcctgcctca gcctcccgag tagctgggac tacaggcgcc 282000 tgccacaacg cccggctaat tttttgcatt tttagtagag acaggatttc accgtggatg 282060 gtctcgatat cctgacctcg tgattagccc acctcggcct cccaaagtgc tggattannn 282120 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 282180 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 282240 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 282300 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 282360 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 282420 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 282480 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 282540 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 282600 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 282660 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 282720 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 282780 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 282840 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 282900 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 282960 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 283020 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 283080 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 283140 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnttta tgtaagctca agcaggtaat 283200 atatggaaag ggctttagaa attgcacggt acacagtatg tattacatta ccacacttat 283260 atagaaagga ttatcttccc tcttttatta actttgaaga ttaacagaaa ttatcagcaa 283320 acttgtcgta taattacact agcaatttct ctctgtggat tcactctttt actgcttacc 283380 tttatcttta ttctgcatac ctctgttctt taatcagcaa ctatcaaata aaagagtaac 283440 cgagacagaa aaatagactt tcagaagtgt aaagtagcgt attccgcatt gtttataata 283500 atcactatca cttggggaga tatcacctgt ggcgaccagg tcatctcttc ccaagtgata 283560 gtgattatta tattcataat attcataaat ttagcctttc cctgttaatg acatcatata 283620 ttgttttcat caaatatgtt ttgcaaagac taggggaaag ttgcttttta atcagctgca 283680 gccagttgca ttttccaaag acagctgcaa caatatctcc caccatctcc catcttttgc 283740 cactgctcca tcaagaaggg aaatctgttt ctctgtgtcc ttgaatatga gtggaccctg 283800 tggactcatt gaccaataga atatggaaga agtgatgctg tgctggttgt aagcttcaac 283860 cttaattggc ccaatagctt atgcttcctg cctcttggaa agtttgcaat tgaacgccca 283920 tttttggatg cttcttctag aaacttaggc atcattctct gaaaagctca agccacttgg 283980 agaaggcaca agtaaacatt ccagttcata ttgctggctg atacccccat catcagccag 284040 ctatggcagc cagccatatg agtgcaccgt cttgaatttc cgaagtcagc cttcagatga 284100 cagcagccaa aaccaaaatc taattgcaac aacatggagg aatctaagct ggaaccaccc 284160 agctcagaat ttacctatgg agccatgtga gataatcaca aattgttgct ttgagccact 284220 aagtgttgag gtggtttgtt acacagcaac agacaaccag aacaccaact gatctgctgc 284280 aagacttttc caaatgtaat tgtctttcat tccttcctgt gaatccatta ataaaatttg 284340 actgagacca gcataatttt taaactaaat cctttagtag tttcctcata gtaatgctgt 284400 gtggttttaa aattctataa agtagtttta aaatgtagac atatttccat ttgtttttgc 284460 aatttactgt ggaagtccat tcttcagaaa agatgaaatc tatatgtgaa gacaaaaaag 284520 attgttttac tcacctattt gtgtgaggat tttgagatta aatttgaatt tatgttaaaa 284580 aggaatggat tttaaagact cagtaagatg gattttcaaa tgtccattct cctacatttt 284640 aaataatcat gtcagataca ttgcagccag ttgtctgtga ctggtttcct cttttgggga 284700 atctttttgt ccccaaatga agtatacatc tcctctttct cataattata aaagtaatac 284760 atactaggta ttaaaaatcc tagcataaac tatgatcaaa gtagaggtaa gagtcctcta 284820 aataggtcac atctcagcta gtgttcaata accaggtgtc actggccaag ttatttcatc 284880 tctcctgtaa tttggtttcc atgtataata cctacacaat gaagataata ataatagttt 284940 ataagattgc tgtggaatta cataaaatag taaatacaaa gcacttagaa cagagcctgg 285000 aatatagtag gtattcaaca aacattagtt ttaattaata acagtttgat gtgtgtgttt 285060 ccttcccaga ttctattcta agcatgcata attatatata tatgtgtgtg tgtcatatat 285120 atttaacaaa aaatataatt ttaaatgctc agttttcaac tcaatttttg aactattcac 285180 tatataatat ggacatggtt ttataatgat atatagaaat atgtgtcatt agtttttgta 285240 atcacatcat gttctaattt attaataata tttgtgaaga atacgcagcg ttctatttta 285300 ttttttaaac actttgagct agtataaaac actgaaatta acatctttat ttacaaaata 285360 agcagaaaaa caggaaaaat gatcctgtta aaatataaaa agacttttac tcaagtagat 285420 cagaatattt tatcattata tggcaagtag tttactgatt ctaaatcttt atagacacta 285480 aaaggctgct aatctacata caaataacaa atactgatga aactaataaa aaagaccatg 285540 agaaccagaa aaacctaggg tctaagaatc ccatattatc agctctctta aacaacttag 285600 ttcaaaaaaa ctcttgagtg tctacattaa tactaagctt gtcacaaaca gaacttttat 285660 tttttatgac aggtaaaatt ctaattaaaa agtaaatact aaattccaaa tatgcacaca 285720 tatctgaaga cagattttgc ataaaggata tcaaatctta ggttctaaga aactgactga 285780 aactgaggta tactggcaca tgaaaattga aatgacctaa aggatgaaat aaaatgtcaa 285840 agagagcaga aacttgttta atcagtgtaa gtctggtaaa tttcgcacaa ctagacaaac 285900 ttgcctgtct tgtctcttat cttcaatccc tttaggcaga atctttgaac actaatagtg 285960 gtagagaggt ttgtcttgat gggggagagg aaggacggat ttacttccga gagtttcctt 286020 agcccctggt cttaatttgc cctccaaata aatatatcat ccttgcaaaa atatcaagct 286080 ttctatgaaa agacaaatct gaagtgtgct agccaccacc tttcagccag ctggacatat 286140 ctatgctcat ccatttggca attctggagc ctccacaatt gctagatgtt ttggacattt 286200 ttgcacaaca tatcttttta catgaagttg tttatacata tagatgtgtt aacagaagct 286260 tttgatttgt cagtgtcatc atataagttc ttatctttct agaagtgtta caaagactca 286320 taaatgaaag ctattccatg tggtaggctg aataatggcc ctggaaaaag gttcatgccc 286380 taaacctcag aacctgtgaa tacgttacct tacatagcaa aatggactct gaagatccag 286440 ttaagttaag gatcctgaga tggggagatt gtactgattt atacatatgg gcccagtgta 286500 atcatagggt cgttatgaaa gggaggtagg agggcacagt caatgaagga tatgtgaccc 286560 agaagaagag ggagggaagg agatgtgatg acagaagcag ggctcatagt cagagagaca 286620 gatttaaaga tgctacattg cttgcttgaa ggtggaggaa gggacaatga accaaaaact 286680 gcaggtggcc tctagaaagc tagaaaaggc aaggaaatga attcactctt cgggcctcca 286740 gaaggaatgt agccctgcca atccatttgg ttttctaacc ttcaagtttt aaacacgcca 286800 ggctttaaac tagttaataa taataataat aataaaagga caacattttt tggggcaaat 286860 tttcaccttt attacttaaa aaaaaaggct atgatggagt ttgtggttta tattttccag 286920 aatgatacag ctttatctat tctatttgca gagtagaaaa ggtgttctct ttggtcaggc 286980 ttattcttaa gaagtaaaaa ggaggagatg agtcaaacat gcccaatatg ttgtcttgat 287040 tttaccaaac aagtaattca cagtttctca ccagaggcat gggcagatga tatttgtgag 287100 atgatgaatg ggcctcaact aacagttatg attcattaaa gagccacagg ggtcattttc 287160 tttgttccct gtaaacatta gcttaacatg ctactgttgc atgagcaact aaattgatcc 287220 aggcatggga ggaaatgtca gaaaagtgaa agaagaaaca tttctcaaat aactagattc 287280 taagattgtt accaacagac cttctattta gtcattttat tgtttataac tcaatattca 287340 attctttaaa taaaggacat atttataaaa tgtactacct aagaatgttt gacctgttga 287400 ccattttagt tgctcatgtg gggaccttgt ctgttactta tgtatttcct gatgtctggt 287460 taagaaggat aaccattcac attatctttt gagacaatta accatatttt ccgcaaacct 287520 tttgtttcta gttagtttcc aacacccttc ctgacaatgc tcagacattt ttttcttttc 287580 ttttcttttc ttttcttttt ttgagacagt ctcgctctgt tgcccaggat ggaccgcagt 287640 ggcgcaatct tggctcgctg caagctccac ctcccgggtt cacgccattt tcctgcctca 287700 gcctcccgag tagctgggac tacaggcgcc cgccaccaca ccccgctaat tttttgtatt 287760 tttagtagag acggggtttc accatgttag ccaggatggt ctccatctcc tgaccttgtg 287820 atctgcccgc ctcagccttc caaagtactg ggatgacatt tattttttgt cttctgaaca 287880 gcagcatgtt atgctaatgt ctacagggaa tgatgaaagt gccccctgtg gctctttagt 287940 gaatcataac ggctggttga gacctgtgca tcatctcaca aatatcagct gtattacttc 288000 cttaaatgtc ttgcttagtg cctctactga aacatctacc agttcataca gtcaacataa 288060 ctcaatttcc gtacactgta cttcccacag atcaaacttt cactatatgc acaaacttcc 288120 tataatttta ccattcaatt gcctggactt ttgtaaaatg tcagataaga aaaattccag 288180 aagtagcttt tgctgtgtgt tactctccta ttgctgaatg ataaaatacc acaaattagc 288240 agctttaaac aacgccattt accagtcata gtactgtagg tcagaagtcg ggctgggtgt 288300 gactgggttt tcctctcagg gtgttacaag gctgaaatca agttgtgact gtagcagggg 288360 ttctcatctg gactcgggtc ctcttccaaa ctcactggtt aatggcagaa tccattttcc 288420 atggtcataa gactgtgtcc ccactttcct cctggctgtt tattcatcac tgctttcggc 288480 tcccaggggc ttcccttctc atcagctgtt caaacgtgga tatttgcttt cttccaggcc 288540 agcaggaaca cctttgactt cctcttctgt gaccagcaag agaaaaatct ctgcttttaa 288600 aagtctcctg tgattctagt aagcacacct ggataatctc cctttcttaa agtaaactga 288660 gccatataac ataaactaat tgtgggagtc taagtctttc atttccacag cactggaatt 288720 attcagaatc tgtatgacag aggaatgaaa tcttggggac catcttagaa ttttgcctgg 288780 caaatactgt tagtgattgc tagccagaga tgcccgattt tcctgtcttt ttttgttctt 288840 atttttcatt tggctcctta tctttgtaaa actctatcca attgagctgt cactcaatat 288900 ttaaagcctt ctaaaaactc tgataaatat ctgttaaaat ttttcaaaaa gtctaaaaaa 288960 ctggtaaaat aaacagagta ctaagaacca gatatatttg ggcaagtgtc agaatttcac 289020 ttactagcta ttagagcaga gccagtaagc aaggtagtta tggagacttc ttagtctgtt 289080 tccactgtaa aattgggaca atgattgcta ccctctagaa catcatcatt gtctaatgag 289140 tgtattaaca ttcttaccac aatggtaggg ccagagtggt caactaacaa tttctgtcct 289200 ttgttttatt tctattttct ttccattttg gttctgcttg gtttgtattt aaatgcaaaa 289260 gtctccaata gaggagtcag accagatttt gccttacaga aaaatgttac atttccacca 289320 atacattatt ctcaatgggc tttagaatcc tcacaattta tcaccaatac cagcagcttg 289380 cctggaattg aagtgctatt ataatctttt ctctcttaaa tgcttattat gggaatcaaa 289440 tggacccaca catggatcat taaaataata agttacatac ttggggcacc cacactatac 289500 cttgagtact ttaagtattg attatgggag gtgatttatt tgtaatattt ttgtccaata 289560 cgtgcaatac attctgctta tatagcttgg ttctaaaact ctcccatatc tagtagaata 289620 atttttagct gaatttcctc tttttccctt agtatattct cagtgatgtg atcatatttg 289680 ttctctagtt caccttctct gtttttttta atcttcaagt aatttctaat tttaattaat 289740 gacttagaaa ttcaagtgcc cctcaaatta ttcttggctt tgtttttact ttacagctga 289800 acttcaactc ttgctaggtt ttccaattct ctttcacaat ttattcattt tgaaaaaaag 289860 aaaaaaccct aaattactgc ttgttttttc attcatgaat atagttttgt cacttaattg 289920 tgcaagattt gtgggcaagt tattttcttg taaacacatt gtggtgcttt taaatgactt 289980 tgagggttcc cctggaatgt tgagtaatgt tttcaaaaat gttttaagcc cattctgtca 290040 gtttttgctg tttctttgtt ttactttctg tcattaagaa ctcgccttct gatgaatacc 290100 ttttagttcc cctcactttc actaaaatgt tgaatttgat cttggcaaat tacccttaat 290160 ttgtcattct tttgaccacc acacagaact aagtctatta tattttatcc tccttgaagt 290220 tctaagggaa tttaatcttg gaaagtcatt tatcttctcc aaatatctga caccaacatt 290280 tttgtcctga ttaaaatttc tgccaatctg tatagagaaa aatgtagtgc cttattatta 290340 ttattattat tattattatt atctagccta gttttgttat ttttgctttg tctaccatat 290400 tcagctcatt ttcattatca tagtattttg ccacattttt attctttaaa tacggaatgc 290460 ctgcttacca aaattccatt tactttcttt gtctggcaaa taattttatc ctgtatcact 290520 caggattcaa acattttgaa acgctcaaat ttggtaattt gaggggaggt aatgacagaa 290580 ctattcacaa gaactcagac agtgtttaag agaaacactt aaatgaatgg tgcagtggcc 290640 cagggctact cacagtatag agccaccagg ggcaagcagc agaatgaatg actatgctgg 290700 aaccctgaga cagctatatg ctgagggttg acagtatcta caaacctcag tgaaagatga 290760 aaccaaccac tgcaacccca taagatttga atctggggaa taaatactcc aacatggctc 290820 tccttcctct ccagtttttt ggtggaaatc cccactgctt gaaacccaac aagaagccag 290880 gaaaataagg aaatccgtgt agcaccttct ctctattctg aggaggaaga gaaggataga 290940 cagtgaacat agaagggcaa actgaggaaa tgcagcagac atatattacc atttatacca 291000 ccatttcaat tctttcctag agaggtcgtg gcttgggagt tgcatatccc aaatatttgt 291060 gcttgttcaa ttattttccc ttaagttagg ctccaaaata aataccattc gatgtctcta 291120 tattttgcca agcattccac accgctatgg cctctgaaat tagtttgaaa atatctatgc 291180 attccccatt aagatgcaac ttgatttcac ctctctggga agccttccat atactccacg 291240 cagagactct gaatatttgt tgtttcttag gtggagttct gagaagcagc agcgtctaaa 291300 atatcaatga aacaaattca gtctcttcct gtcaactgaa atttgggtac atggccttct 291360 taactatgtt ttcctagtga tgttacaaga tgacaaaata ttagctcagt ccttgttctt 291420 ataagcattg atgctacaat attatctgtt ttattaatct ctagcaaact ataacaacag 291480 taaggaaaat gaatctagga aattaattct tatcttatta agttttaatc tctttctttt 291540 caaatgtaat acatgatagg tcagctttgc taatggtttt atactgtctg ttataatctt 291600 accagtgtgt tcattctatt tttttcagtt cttctgtacg atttgaggga ttataaaaag 291660 tctccactga catcaaaaag tctctcccag tggcttacca tagtgcctga aatttccatc 291720 ttcagagaaa cttttctgat ataggacttt atctcagaaa gtgtttatta agtggactta 291780 gcttacctaa gagaggtaac atgttgacac attcaatgat cagcttcaaa gtcatcaggc 291840 aaaaagaagg aaccattggt gttttgatga aagttcctgt ttagagaagc taacggctta 291900 accttcagct gatggaatta accccagctt ttatatccaa catatttcta gttatgggta 291960 aagccagagg agcatagaga ttgcctgtaa aaaattctaa agctggagct gagatttagt 292020 ctcttatctg aaaattaagc ctcatgcatc tctgaagtca ggaagtgctt aagcaagacc 292080 cttggataaa tgtatgtact ggtaaatttt cataagggat aagactcggt aaaagttcag 292140 aactagaggc aaggtctagg gaggtaactg tagctacagg ataataggac cataaataag 292200 gagaataggg tagacagtca gatgttcaaa agggaaatgg ttataccaca agcacatttt 292260 ccccactccc cagttaatca atattgggcc ctatctttca gtacataact tattggctac 292320 agaactcaaa cgtactcttt gatattttct ttatgataat gataactcat actttttcag 292380 tatacaaggc aatgttttat gctttttaca gatactgctt atttaatcat cacagtaact 292440 ccataaagtg ggtaacacta tcatatccat tttacacata gggaaattaa ggtgtcagag 292500 cagttaagta acttattcca aaatgaaaca atgggaagta gcagacccag gaattaactc 292560 ctggcaatta aagcaggctt taagcttaac ctctacatta cacagcctct catggaccca 292620 gggaacaaat aacctatcac tcagataaat gtgtgctgct gggtgaacaa atcacatcat 292680 cctcatcctt catccttctc tgtggtctca atgtagaaat ggacaatagc agtcattacc 292740 ctgttacttt gaaaaggtac taagcaaggt cctgaagcct aatatgtgta agacaaaaaa 292800 gcaacagtaa atgtagccta gggaaatttg aaatgaaaca tctctccctc ctgcaaccac 292860 ctttggaaga acacacctgg ggcaagaaga gccactgcaa agcaatccct gccatcaagt 292920 atctgctgca gtttcctgcc tctggcagcc ttagggagca gggaacatct gtagcagcta 292980 cctgctgcaa ggccttgtgt ccaagcctgg gagaagggtg ttccccacta aagctggaca 293040 atgctaaaca tgacactgcc aactggaata aaaagcccta ttctcactaa ttttccagga 293100 tatcgtttct acccatttat tcttctgtaa aaatagtata ggcataaaag aataaaaata 293160 aaaatcccaa gttaaaatag tccaacagaa tatgaacttt tgtgagaaga ggagagggct 293220 aaaataccta gggaaaaaaa tacctttact ttcacctttt tctgcttcta tatcatcact 293280 cttgtgcctg acatacctaa agagcctaat ctttacccca ctaaggtctc tgtatctatt 293340 gcaggggact cttacaagag gtctgagcta ccttcaataa tttgtttgtt gtcttaaaac 293400 acgccttttc ctgtgttggc tgcagtagag aatcctgaag atacttgcag aagttgaacc 293460 ctgggacaat atagagcttt gtgtgacatc acctattaat aggtgtaaat gaaggcctcc 293520 ctctgttata caaagacctt tgcatgcatt agaccaccta ggtcagaatc ctgattctcc 293580 tacagactag ccatgtgact tgggggaaat tacttatttt tttcatgtct caagttccac 293640 ttctataaaa tggggatatt tagtggatgt acttccttag ggttcttttg aggattacat 293700 aagacaaaga atgtcaagaa cacagcataa taactggcat agagcaattg tttaataaaa 293760 gttagctatt atcaaaatca gatgtactgg gcatgggagc aataaaatta gtcgtcttga 293820 gaaagggcca cacaccactc acgttgccct ggagtcagtg tttccacatt gctcatgctc 293880 tccttcagcc tcagatgcct ctcctcctaa tttctaccta tcacaatcat gtcaggccca 293940 gcttgaaact atgattctga tatggttagg ctttgaattg taatcccaga gagagacctg 294000 gtgggaagag attggattat gtgggtggtt tgccccctgc tccccatgct ggtctcatga 294060 gactaagtga attctcacaa gatctgatgg ttttataaat ggtagttttc ctccgctgac 294120 acacgcgctg tctcacctgc cgccatgtaa cacgtgcctg cttccccttc caccaagatt 294180 gtaagtttcc tgaggcctcc ccaaccatgc agaactgtga gtcaatgaaa cctcctttgt 294240 ttatgaatta cccagtctca gatagtatct ttatagcagg gtgagaatgg gctaatacag 294300 cttccctcac aaaacctttt atatgcctga gcggcattac ttgtcctctc ttcagacact 294360 ccatcacacc cccaggagtg gactcttttt tttttaaata aaagatccct gtttttagtc 294420 atgtttgtaa ctcttacaat tttctggtat agtacttttt acacagtagt acctaaccca 294480 ttcttgttaa attttattaa tctacaattt attttattca ttctaagcta tgaattaggc 294540 tcacattgtt tgtaactccc tgctccaaag ctataaacat agagcacaat gtatggttcc 294600 tttcgacagt catacggaca tcatgggcac accaggcatg tcaccattca cagcctcagt 294660 tagaaatgac atccacacgg ggtggctgtc cccaggattc tcactgcggc ttgaccttca 294720 caatcgtgtg cacttactat ggcagtatgc agatttgctc atattctgag taagctcagt 294780 cagttcagtg ttgtgttaaa gcaatttgac cgaacaaatg gcagtttagt gggtgggcct 294840 gctgtaaata catttgaggt gtgataacat aaatatgtct ggtgaaaaat aaaattggac 294900 caaatgacta aatatttgct tgggcattaa aaaaaaagaa ttaaaaattg tcacaaatgt 294960 gcccaaactt cctgatcata aatgtagact tggtttgcct ggagattgag tgcagcaccg 295020 caaatcggcc tcagcttatt ttaacactca tatttcccaa tacactaatt caatccacaa 295080 agctccaaaa ttaagtagga accagagctg agaagtgggt aagcaccata ggacatctta 295140 agagactgcc tctgatttat gcgtcagaaa atgtgtgaga gttcttcctg atttaaatca 295200 ccaaataatt tgtccactgt taatcaaata taaaacagag ctgaacttta ttttctcaat 295260 aaccaaattt ataagtatga aaagacccta acacctgagg ataaatgtta agagagaatg 295320 tgtcaatgaa aatgggtggt agtcaacaat taattagaaa ttcacatata tccatatttt 295380 gaaaaggaag gggaacaact cctgaggaaa cacagtcaaa aatatttcct tggatatgtc 295440 agagttatct cataaaattt cttgtgcaga atattaatag agtattgaat taggtctttt 295500 atgttataaa acctgatctc tgtcaagcag tatgaattgg tcctgggatg tgaaaaactc 295560 tatcatattt tatttagcaa taatctttta acttagaaca agcttatgag gaaatcattg 295620 cttcaagata tgtaatcaaa tatgacaata ctattttaac tagattcctg agatctcaga 295680 ccagagccaa tatcaagcaa atatatcaaa taggtgacag tggcctttgg cattcccttt 295740 cctctcatgg cccagcactt tgttccctgc agttcctccc tctccttagg tgacctgggt 295800 gacctttgat atttactttc ctccctctca gaagggtgtc tttgaaatag ggagggagca 295860 ggacacaact cagtgtttcc cagtgacatt ccaaggagct agatgttatc gcagacttct 295920 ctaaaatagg acttcagagt caaataaact tagaaaatgc tgcattggac aaagtatatt 295980 tacttgtttt tgcaaaattt ctcaaaacct ctataacact aatatgagct gagcatctcc 296040 tagagaagga catttcctaa attgggttaa ttacggcaag ccctttccag taatatctgt 296100 taacatctca ctcttcgggt aacactaatg caagggaaag atgaatgcag gacaggtctc 296160 agttcaaagc ttgcttctgc tacttagttg agaaaattct cttgagataa ggttttctcc 296220 tgagaaacat gtggcacatg gaagacattc agaaaacagt agccatgatt taattatatg 296280 gttgttaata attgtagtaa taataatatg tagcgatcca gggagcaaag tattcttaaa 296340 cactttaatt cccttatttt taaaaagtcc taagccaatg aaagggaggg tagaaggaaa 296400 acggtcatga gccaatgtag gactgaatag attaaaatga aatgtggggc tggagacagg 296460 ctggacaaat agatggtgtc ttgctgcctc ccagttggca ggagaaggga attatgccta 296520 agttaggagt gcagtggggt ggaaatggac aaggctgcaa gaaagaagtg ggaagagctg 296580 taattatcaa gccattgctt ataaaacata aaaaatatct tagaatacac ctgatttaaa 296640 agtcatggaa ttcagagtct tggcttaatg aaggaattgg aacccaagca ttctgtccca 296700 aaacagaaag ggcacaaagt gtcccaagac caagggacgg gagggacaac atgcatggct 296760 cactttacta ctgcctaatg gggatgataa tggtactatt gccatttttg tgaggatcta 296820 aatcatatta aagcatgtat agccctcata acagtggctg gcacacaata aatgttagct 296880 gttggcatta cctttttttc taaaatgtgc tttcaaatgc taatcctggt acctagccca 296940 gtccagaaat aaagattgtt tcacacattt ctactgcata ccaaattcca tggactatgg 297000 agcttgctga aagaagctaa gttctgtcat atacattacc cggagcacag tgtgcttttt 297060 aaaggcagtg ggacaatcca cagggataaa ataaatacaa gaaataaacc aagggcctca 297120 tcactgcaaa ggtgaaaagg aggcatattt tacctattac atgataaaag ggccttcccc 297180 ctactatgtc ctcactccca ttcaaaaatc tacttgatgt accttctcat ctggacaaga 297240 gaattaatct gatgagttca tctcaagctc cttaagggct gagtgactca actgcatcat 297300 tgaatatttg gagaaagttt actcactttt ttaaattgag aaattgattt ttatcattca 297360 agttgataat actaacactc acttattgct aacatctttt atgccaggct ccttgctaac 297420 tactttacgt gtattatctg atttgacctt ccccacagta ttaaatagga tactctctct 297480 cctcccttcc ttattttata gatgaggaat ctgagtcttg gaaagactaa gtaatttgtc 297540 caaagtcatt cattcactaa ataatagtag agccaagtct gtccaattct aggggctaca 297600 cagagctgca catccaagaa atttactact caatatcact gccttcccct tctctgagtg 297660 tttaaaattg ttttaaataa gaagtaattg aaaataaatt attcacactg ttggcatctc 297720 agtcattgtc aatactgcca cacagcagaa catgaatatg acaaccaggt ttgtgttaat 297780 tagattagtt cttcattttt aaatgacagg taaatatata taatctctct tggaaattct 297840 gaaagggtca tcctagtccc atattacccc atcaactaca tcaaccacct aacaatctaa 297900 atacattcac tattgttgta atttaatcat gttggtgatt gtatttgtgt gtgtgtgtgt 297960 gtgtgcgtat gtgtgtgtga gagagagatt atgttaagga tgtttcttta gacctaatgt 298020 attatcagat acactgccaa ctttttgcca gctcagtttt ttgtttataa tgcttctata 298080 tacattattt tatttgttca taaaacttcc tcctttttgt tttcagtagg ctcctttagt 298140 cttaaccatg tgactggtaa aatgagagaa acgggcaagt attctactga aggccacaag 298200 cctcccacat gcaagtggga cccaatccat caggctaaac agactataca tggccattca 298260 gactgtctat cccatttatt tttgttaata tgattttgca taagagttat agaaatcatt 298320 aaaaagtcag gaaacaacag gtgctggaga ggatgtggag aaataggaac aattttacac 298380 tgttagtggg actgtgaact agttcaacca ttgtggaaga cagtgtggcg attcctctgg 298440 gatctagaac tagaaatacc atttgaccca gccatcccat tactgggtat atacccaaag 298500 gactataagt catgctgcta taaagacaca tgcacacgta tgtttattgc ggcactattc 298560 acaatagcaa agacttggaa ccaacccaaa tgtccaacaa tgacagaccg gattaaggaa 298620 atgtggcaca tatacaccat ggaatattgt gcagccataa aaaatgatga gtccatgtcc 298680 tttgtaggga catggatgaa attggaaatc atcattctca gtaaactatc gcaaggacaa 298740 aaagccaaac gctgcatgtt ctcactcata gatgggaatt gaacagtgag aacacatgga 298800 cacaggaagg ggaacatcac actccgggga ctgttgtggg gtggggggag gggggaggga 298860 tagcattagg agatatacct aatgctaaat gacgagttaa tgggtgcagc acaccagcat 298920 ggcacatgaa tacatatgta actaacctgc acattgtgca catgtaccct aaaacttaaa 298980 gtataataat aataataata aaaagaagct catcaaagaa aaaaaaagaa tcacagccac 299040 taacaattta aataaagtta taaaacctaa gtaaatagta aaaaaaaaaa gagagatata 299100 gaatagtctt tctaaatgtg cttttgtctc ttcagtcaaa taaatagacc ctatatcttt 299160 taaatttatt tctcttcttt aagacatcac taatactaac acagcccatg tctgtgtgct 299220 ctggacacca aaatacaatt tcatacttaa aacaatttgc tatatcccca actccaaaag 299280 actgaatttc aagaacatag aagaccatca agatatgacc tcctatcact caagtcctcc 299340 ttttgaaata cctcttctct tagcctgcaa cacaccacag cctttttttc ttcaattttt 299400 attttaagtt caggggtaca tgtgcagaat gtgcaggttt gttacacagg taaatgtgtg 299460 ccatggtggt ttgctgcaga gatcattctg tctcctaggt attaatccca gcattcatta 299520 gctattctgc ctgatgttcc ctttccccga tcccccgcct cttacaggcc tcagtatgtg 299580 ttgttccccc acatgtatct atgtgttctc atcattctgc tcccatttat aaatgagaac 299640 atgcagtgtt tggttttctg ttcctgcatt actttgctga ggataatggc ttccaactct 299700 attcatgtcc ctgaaaaaga cctgatctca ttcctttttg gctgcataat attccatggt 299760 gtatctgtac cacattttct tgatccagtc tatcactgat gggcatttag gctgattcca 299820 catctttgct attgaacgca ccacaatctt gattatcttt ctacctcacc atctgctcct 299880 acccaatctc tgctagttct ttatcttccc ttctttgatt ctatggtgcc tccagactca 299940 ggtcacatag ttttccaact atattgattc cctgtgtgac ctcatccagt ccttatacgt 300000 aatccattct ctaattgttc ccaaatttgt atcctagctt gggccaatcc ctgaacttaa 300060 cttcagtctc ctggatccaa ctaccttctc aacatctcca cttagatatc taataaacaa 300120 ttgcaaagtc aacatgctga aaacatgtgg atttacacaa tcccaaaagc caccttcttc 300180 cacagtcttc cccattttaa taaatggttc tgctaccaaa tttgttgtca acttggacac 300240 ctctcattat cttatgtccc atccaatgta tcagcaaatc ctatacgctc tacctcaaaa 300300 catcccaaac agacccctca ttaccacctg caacaacaac accctgggcc aaactgccat 300360 cttggcttac caagagtatt gcagtatttt cccaactggt ctccctcctt ccatcctggc 300420 ctcctctata agctattcat cacacacaca tgtgaaggaa agttttaagt caaatcatgc 300480 taacccctgg ataaaactct ccagtgcctt cctgtctaac acagtgaaaa gcttcagatc 300540 cattctttgg ccttcttccc agtggcttct ggcttctccc ttgaccttgc ctactctccc 300600 caccttgccc tgtcccacaa caaccataca cagccctagt tacattggct tctatgctat 300660 tcctcaaaga cataagatgc cctgtgaaca caaaccacac acagtacaat aaaacgcctt 300720 taaagcagtt caaaaggagg agtcccatca tcttattgta aaatgcaact aggtatacgc 300780 caccaactta taaaataaag tatacttttc ataattattc agattacctt gagtttgctt 300840 gctctatggc tgcagtcaaa aatcacatac tctaaaaatt ttattaaaat tagcactgtt 300900 cctcctaaac agtcttttcc actttggaaa tgttttcact caggggagaa aatgtggata 300960 tgaactgtag tctagcaata ttagtatatt tgcatgtata attttataaa taatagctaa 301020 tattattgta aataatctgc ttcttaacaa acattattaa tttcatttga atacaagatt 301080 catttaacaa ggtctgaaat ttttttagat ttgtttagaa gtcttatttc cacattatta 301140 gatgtctatt tttttttctt cattgcttgg ttagtgtttg ctgggttagg tttccattgc 301200 tcttgctccc aatgttgcat tcaagagaaa tacttaggag cacagagtga tgacttctta 301260 gggcaatgtc acttgaccaa agtagtatct tgacagaact tagttggagt ttgtagaatt 301320 atccaagcta aaatatttct gttctataaa atatattcta ttcttctctt cctctaaatt 301380 ccatgtatct cctttcattg tctgccttcc gggaggctat gcaagattga tggagatatt 301440 aaatccccaa actaaaagag aaaagtatgt gaatgtgagt tttcagttga cttgagagga 301500 aatatattgc ttaatagaaa tgtacaggaa acaatgatag tgggcaataa atcccagatt 301560 aattacattt atttaatatg ctttagagcc aatgcagata gctgaacttt tatataaagc 301620 actataattt tatgattttt agtactatga tttttagtaa ttcagtaaat tactaaatca 301680 gaaaatttac tgatttagac agtaaatttt caaacacttg tattagaaaa catgattttg 301740 ccccttatta ccaaaagcaa aactgctcta ttacaagcct attagatctc tatccccaca 301800 tattttattt cttgatttct caaacacttt ttatgttttt ttatagtcaa cagtacaccc 301860 caagtgttgg aaaatttgaa actgcttaaa tagcaaatgt gcgaattcac aatgatattc 301920 taaatgatcc aggaaatgtc attttaaatg gtaaaatcaa tatgtatttt ggttcattag 301980 gaaagtacat aatgactatt tctagcatct cctcagactc tgtttaacca gtgtgtgctg 302040 tgatgcctgg cctgaagcac ttctattttt agttctaata gaacagtctt aaattgctta 302100 ttttctgttt actaaagtca tcccgtttgt taccatggaa actatgacaa gtgctccagc 302160 taactatttt attaaatgaa ttggagacat agctgaagaa gctgaagact gaaggtgcag 302220 cttgccattc ctaaggcata ttttccaaca tctgtaaaac cattgccaca tttatagata 302280 atatgaaatt agttataaat aaagttatcc acatttcaaa tttgggaagc tgtccacatt 302340 tgtattataa ctagcacatc tgaattataa ggagcacata ggcattccta acttacaaaa 302400 agtctttcta aaagtatatc tgtcgatcaa ttccttggaa attagaacat atttacccat 302460 agaaacaatt ttataaataa ttgttagatc tccaggccta ccctcaaaat ccctccccta 302520 tgaagtcctc gatctgtggc ggtctccata atagcttttg ttctcagctc tagcagcagg 302580 agccaagatg caggataaga agaaaggaaa gagttttctt atgctgactt tattagagct 302640 tacataggtc accatttggg atacttgcat ctactggcct ttgcagatgt tagggctccc 302700 aaaaagatcc ttcagctgtt tgcccggccc ctgtctccag cctccagggg tcctggcact 302760 tgctcacatt tccgtctgat gtttcatgcc agactaatct tgctctcaac ctccccccgc 302820 ctctgcattg aatcatcatt ctcctcaaga ttcaaggtgg tctcagctag ttgtgaaaaa 302880 aagcagtcga aatggacaca tttcctaaat caggggggtc cgatcttttg gtttccctgg 302940 gccacattgg aagaattgtc ttgggccaca cataaaatac actaatgcta acgatagctg 303000 atgagctaaa aaaataataa taagtaaata aaatatgctc aatgttttaa gaaagtttac 303060 aaatttgtgt tgggccacat tcaaagccat cctgggccac atgtagccca caggccacgg 303120 ggttggacaa gcttgtaaat gattaagaac accttctgaa gttttggcat tttaaaaata 303180 ctttatttgt aacttaaata gctggaacag aaacaaattt caagcctgtg aaatttccat 303240 taccttgact aaagagcata ttcagagggt aaaagtgtga ggaaactgct ttgagggaat 303300 tctagaagtc agctgcaagg agtcagtcag cagtcagttg atttaaaaga agtctacttt 303360 tcaagtgtat gctctgaatc ttggacctgt gggtttctgt tggaagacgg atggtagtgg 303420 ttgattgcaa actgagtcat acctttgttt atttcatttc cacagaattc taatgaaata 303480 tagcttacta gccctgtaat tttgctttta gaagaatatc gtcttgaaga gtaccatctc 303540 atgaagaaga ttactaacac aataatatag acaaaacttt gttcttattt tctaacagaa 303600 taaaaaccaa acaaaaccat tgtaatttgg acgttgtgaa ttttgcacag aaaagaaaag 303660 aattactgta acatatataa gatagagtca ataatttacc attttatgtc caataaatta 303720 aaagagaaaa agcacataag ttgcttattt ttaaaatcaa gatgacatga gttgccttca 303780 ttttttatac agctatattt tatagagatt cagatttaat caaaatttat aagaaaatgg 303840 taagaattat ttctagaaag ttaaagaata tatcttttta aaaattaact attataggga 303900 tgggtgtgaa agcaaataga atttgatatt tctgtttttc cacaatgcag taactgaatt 303960 tatttgtaac gtttttctgg aaagacatat gtattttaaa tgaatatggt atgcaataaa 304020 atatgaagta aaaaagatca aattattttt taatatcagt gatcatttaa gatacaaatt 304080 tccttaagag tatatttcaa ttttaatgtt acttgatagt tcagaatgaa ggcatatttt 304140 taactaacat tcatttttaa tctccttagg gtccactttt atttgtaaca ctcacataat 304200 tccagtgaaa aaccaagagg gcgtggctat gatgttcatc attaattttg aatatgtgac 304260 ggataatgaa aacgctgcca ccccagagag ggtaaaccca atattaccaa tcaaaactgt 304320 aaaccgtaag taaaaggcaa tgtgtactca atgctcttga taattctgct actgtagtca 304380 ctttaataca gtcttcattt caattcagtt ctcaaaatat ctttatattt gaagtaaaat 304440 aatttgacat gagtaagcca ttagctcatg ttaccttttg gtaccttcca aaatttgttg 304500 gctgctctga aagccattta acttggatat aatataatgt atttaaccag tcccctgaca 304560 cctgatggac atttaggttg ttttcaaact ttgtctgtta caaataatgc cagagtaaat 304620 tctgcttatg tattttcata tgtatattat tggacaaatg tatcttcagg gtcctttaag 304680 tgggattcct gggtcaaggg tgatgcatat ataatctttt cagatactgt caaattctcc 304740 tccacatgct ttgaaccatt ttacactacc accagccatg aattagccct tttccccaaa 304800 actatgccaa caaagcgtgt cagaatccgt tttctcaact attgtcatta tcataagtga 304860 gaagtagtac ctcaattagt tttagtttat atttattcta tgagtaaggt ccatatattt 304920 aagcacaaag gacatttctt tatcaactat ccatttcttt tatacatatt ggttgttttt 304980 tctctatctt gtcaatttat aatgtaagct gcaaatagct tacctagaaa ataatgcgtc 305040 ttttatcttt ttcataattt ttgttattta aagggttttt tggtaatgtg tctaaattta 305100 taaccctttc ctttattgca tctgaatttt tgagacataa ttagaaaagc tttcaccact 305160 ccaaggttct aaataaatca cttcctttcc ccggaacttg tatgatttca ttttttagga 305220 tctctgatgc attgtaagct tattttggtg tatagtgcag agtatacagt taatttatct 305280 tgttctcaat ggctcactca ttgttctaac attatttatt aaaaagtcta tcttttcgcc 305340 agtaatttaa gatgccacct ttattacaca ctaaacttcc atatgtgctt gaatctattc 305400 ctggattttc tattctgttc tgttgatcta tctatcgctc agaatcatac agtttatata 305460 tacaataaat aactaatata ccatgatccc ttattattcg atattaattt tcagaaggtt 305520 gaggttattt tttgattaat tttccatgtg aactttagaa gcaaattttc tagagctaca 305580 aaaaattatt taatattttt attggattca cattaattgt ataagttaac ttgaagataa 305640 ttgatgtctc tataatggtg taattctatt caaaaatata gtatgcattt ttattttcta 305700 agtctaattt tcgtgtcttt caggaatgtc ttaaaatttt cctcacttgt ttactttgct 305760 ccttggcatg taacttttgt tgttgctgct attataaatg gaactttttt cccattatat 305820 tttcttataa aagtaacttt tctttctgaa tacattaatt ttacatccaa ctatcttagt 305880 gaattcttag tttacagtga cttatacatt gacttttatt aatttttcaa atattctatc 305940 acataaaata aaaattgttt tatatttcct ttccaatctt gtacatctca tagttttctc 306000 ttgtcaaaat gtgctggcta ttacctccaa ggtatcatta aaaagaaatc aacagtgaac 306060 actacgccct ggctctgatt gttgtgcgag tgcctttaat tcaaacattc cccattaatt 306120 gaaataatga catgtgagtt gagttgtatg tgctttatta ttctaagaaa gtttccattg 306180 acttaaattt tttaataatg ggtgctgaaa tttgtaaaat gcctttttta gcctctgtgg 306240 aaatgagtgt attattcttt tcctttttta aaaatatatt ttataaatga agttattaat 306300 atgaaccatt cttgcatcct tggaagaaga cacatttgga catgatatgt ttcattttgt 306360 aatatgttgt tgggttctct taacgcatat taattttgca atttgcatca atatccaata 306420 gggagattga tctataattt ttgcctgcat atgtgcaatt ttctaaggtg ttggtatcaa 306480 tattataatt ccttcaaaaa ataattgaga gtttcttctc ctttttgtat gctattgaag 306540 catttaaata gtttgaggat tatctagact ttaaaagtta ggtgtgattc ccctgtaaag 306600 tcatcgaggt acttatttgt ggtaattgtt tgtgaagtag ctccttgaca aatttatttt 306660 tcttctttaa taatggtcta ctcaaattat caatcttaac tagtttcagt tttgctagac 306720 attatttccc tagaaattat ttcatgtaaa tatttaaatt ttgttttaat agaattatgc 306780 aaggtagtat tttatgattt tttaaaaaaa tcctcagttc ctatagtttt ttcttgaaat 306840 ttctcatttc ttttattatt gttttctcca tttaaaattg ttgattaatc agtagctttt 306900 ttcccaaaga cttaactttt tattggttta ttaattctat tagttttcaa actcacaaaa 306960 ttttgctttt atatgcttaa ttcagttttt atcagcttac tttgttgcct ctttttcatt 307020 gcatcgattt attttcattc tttcagtttt ttggtatatg attttaaggc tatatatttt 307080 tatctaagca ctgtgtaagc tataccccat gaatttagaa atgtaatatt atttttccta 307140 gaaaatatgc aacttttgtt ttcctagttt ttaacttgag ttgtttaata tagtttttag 307200 ttttccagta ggaaaggtat ttttaaagta ttattttttg ttaaaaactt ctggttttat 307260 tgtcttacag tcataaaatg ctgtttgtat tatttctctt tttgtaattg tctaaaattt 307320 gcccgtggtt tattatttga tcaattttca tgagtatgtc atgtgaatat gaaaaaaaag 307380 tgatattaca gaatatcaag ctacaaaagt tgatatctac ttttaaaact ctgccttatt 307440 attatgctgt cttctatatc cttacttatt tcctgtcctc cagatatgtc ttggatttaa 307500 gaaagtgtat taaagtcttc tactgttaga atatttcttg gtatttttca ttctctctct 307560 tgcaatttct gttttatgaa tattgcttct cttgtttatt tcatagatat tcatatttca 307620 taggtagcca tatattttgt tattagtata aattagcatt tagcattaca aagtatctca 307680 tttttgttta ctaattttcc ccctaaattc tactgtatct taaatcatga cacttgagtc 307740 ttttcttttt tccattttct ttctgtattt taaagtcatc ttttagtcat ttgcctttgt 307800 tttggttgtg tcttttttat acagtgtgct gtttttatgc aatgtgaagc ttttctttat 307860 tgcttataag aaaatgatac ttctacgtta attgattata actgcaatag gtatttacat 307920 ttattgacgc aactgatgtg tttgttttct tgatactaac atattctagg ttaaatatac 307980 tttcttgaag tacttcatta tgttatcttt tctttgccct tttaaaaact ggtttttgtt 308040 gttgttttat tctggtttcg gggttttttt ggtatttggg aaaatttata tttttttcca 308100 acagttatct ttataagaaa atgttatata ctctccttaa ctctttcctc ttttcctcag 308160 tcagtgtatt ttggttccct attttgagca aaaataaaat tattacggca aaaacctcaa 308220 ttattttgca ccaacctaat agcttataat ccttttcttc tgcttcccac catgcagttt 308280 tcgtcaacaa tattctattt cttaaggctc atctttgtgc tcctgagtat ctttagtctc 308340 ctgccattca gtgtgtcagt ttaaaataac atcacttgac tctcatctgt taccagtaag 308400 gtactcagtg agcttatcta ttttcttctc ctctccctcc cattttgttg ggatatggta 308460 tttctagctt gtcaagtaga taatgtgtat atacttctta cttttctttt ggcctcaaat 308520 ttctagtgaa atgtatgcat gactgtcttt ttgtcagaga ttccccaaac acagcttctt 308580 aggtgaagta tatccccttt gggaaacgtg tgtgggtaaa atattttcag agttctctcg 308640 tgtttaacat gtttttatat cactttgaca tttgaaggac agcctaggta gatatgacat 308700 agtatttggt ccatattcta tgccttgtga ctctggtcaa tattgtttca ttcttttctt 308760 acatcaactg ttgccgacaa gtagtctgac gtcaacctgc ttgactatcc attgtaagtg 308820 actctggtat ctggggtctt gtgcactttt taagcccctt ctattgtctc tccaggaact 308880 ggtgctcatg ttacagacct gctcttgaga tttcttactc agtgagaggc cctcttctgc 308940 tgaaggtgaa ctctgtttaa taagtgtccc aacactccag ggagacttct gtactcctct 309000 tttcttcatt tagtttcacc ttgactctct gttgcagtgt gcttttctga gccaattatg 309060 cttgtattag caaattcccc atctacatgt aaataaaagt ctgtaagttg tctttctcta 309120 gttactgcat aagcatggtt tacgggtact tttatttgac tcctccttta ttaaatctcc 309180 aaggtttata taggggtcca tgaggatttg gtaatttaga tatctgtcat tatctatggg 309240 aagctggaag ccttatcaca aaactttaat atttgagaaa ggaaattgtt atactgtgta 309300 taaattcaga tagaaaaata tgcgtataat gaaaaacatg gtcccaaaag cctattttgt 309360 aaacctaagt ataataccaa atcaaacata cctcagctga taatttttct taatagcaat 309420 ttttccttag gtatgtctaa atgacagtac aatattcttt taaagcaata ttgacacaaa 309480 tacattaatg taatatgatt ctaatatgtt aaatgttttt ccctgaacaa tattatactt 309540 ggagaaaact ctatcagaat tactaattca tcaatcttcc aggtgacata tttagaaaaa 309600 aaaattgagc taccataaaa aacttcttac cccaaagtct tgatcccaaa gttgatgact 309660 gttttgattt tcttatactt tccactaaca aatgcaatca ttaatgaatg attcctgaga 309720 gtacacttct aatgtcaacc tctatttgtc atgaatacca ataaggtaat ttgtttggat 309780 ggtggatacc tagtttagtt tcttcactgt cttctcaaat tctcatattt tcccacggaa 309840 tagttgtctt tcatggtcca tcaaattgga tggaagtgaa aaagggaggg tatatcagca 309900 gcatggcaga gaaggggact tttaaaaaag ataatgtgtc cgtttaaaac tgaaatgtaa 309960 atggagaatt gaaaccttgg tttcctaaat ggaagatagt ctttacagta gcctccagga 310020 tataatacac aatttatgca actttatatt gtgattaaaa taaagtccta tgtacaagtt 310080 acaacaaatg cagtagagat tctgcttctt attttatgaa cataagttgt ttccctatgc 310140 tttagctgtc actcatacag ggaagcgttg gacagagtaa aaatatgcag ataaaattat 310200 ttccagagca ttacaaaggc ccattattta ccacctgtat atcggttttg attacaccct 310260 tctgtcatta tatgacctag atttcctctt acttggtgtc agtttttgag gaatggattg 310320 ttaaatcaag cagaaaagtt aaagaaagac aaattatgct tgataccttc tgatactact 310380 caatttcgac ttcatatttt ttctcatctt tggcaaaccc ctgctgattt tttttctttg 310440 aagtataatg ttcctaccag tgtaaaataa tgatactggc tatttcaaac attgttgttc 310500 cagtgatagc cacttaaaaa aaataaagaa taaaaaattc tgatgcacct cttttagcag 310560 acacatctta accttcaaaa ttgtgatatt attgcttcaa aacctacatt gtaactacca 310620 gcttttgtat cacttgaaat gatctgaaat aaaaatatgg ttacaaagaa gtatacaatg 310680 gtattcacaa aggcgaattt taaactgaca tttcccttta accaatgctt actctctcac 310740 taaagtgttt gtaattgtgt gtgtgtgtgt gtgtgtgcgc gcacgctcgc gcacactagc 310800 gtgtctcaga gtggtaggat ttcagtgaca gtaataagaa aaaggttgtt gtgtgtttgg 310860 gaagatgtta ctttctgaaa atttaaatac ctctattgaa atagagacaa aataaaggaa 310920 aagatgtgac atgactacac aagaagcata gcttcaaaca aagggaggta ttaaattaca 310980 aagattaagt aaaagaaaag gagggaaata cacagtagaa aatatggatt ataaaaaggc 311040 attatgatac attgggctcc atacattctg aaaacttaga gacttctttt atatagaatt 311100 aagtggtgga tcatttctca gtacaaatac ctagtttcag agccaggaac tctacacaag 311160 aaaagtgagc agctttctct cagaagacct aatttttcat aaacttattc tctgtagaag 311220 acctggaact agccacaatt agatgactta tgtcccctga aatgaagcaa atacagaaga 311280 aagtgttatt ttgataaatc ttactatcaa attttgataa gtactgaata aatgagccaa 311340 ttaattgcta cataatagat ataaacacaa aataaaagat gaaattgaac actttctcac 311400 tgaagtcttc tgtaaaaagt ttgcagtcta aaaaatggaa ataatacgga gtgaaagaga 311460 aaattgtgca ttccctacca agcataaggg gccacattta aaggagccaa tagtaatgga 311520 aaagtgtgtt ctcttctttt cagctgtaat acttgatgat gtagaatata tgtgaaaaat 311580 ggaggagaaa caaattatgc attcttgttt acgtgattaa tgcccgagtt tactgtcatc 311640 gagtataaga ggttttcact tttactgttt taaataaatt atttttgttt cattttaaat 311700 tattgaaaac tatatttgaa tttcatatgt cttctatagc atgaatctag tatcatactc 311760 tgattcacac acagatacat gcacactttt gaattctcta aacatttctt gaagggattg 311820 ggggaaccta aattaaacaa aaattggtac ttaaattgga ttcccttctt ttacattcca 311880 tgtcaccgca ttcccttgag tctttccacc tctgtaacag ctatttcagt accatttgtt 311940 gttcctctta ctctactctt aaaagctgtt tgtttctccc ctgggagctg cttttaatat 312000 tcattccttc ctagtcatct ctatatacgc tgcttaggca aactcattgt ttacttacag 312060 cgtaaagacc ctctcaaaaa tcagtatctc cagctcatat ctttctttag gcttacttac 312120 aacctcatat atcccactag acatctcctt tagaagattt tagtatttct gggcgattta 312180 gcatttcaag ctaagaactg cctttccatc ttcagctacc atccatttca tcccaccaaa 312240 aactcttcct tttcatacat tatgaatagt cattatccaa agctcccaag ccagaacctc 312300 ggcatgatac taaacttctc cttctctcta atcctctatt ctcccaacca aaggctagcc 312360 aagtctatga aacacatctc ttaactatct ctctcatata gcccactata attgtcctat 312420 tcagaccctc aacacatctt tcttggactg atataatagt ctcacaatta gtattcctgc 312480 tttaagcttc ttttcttcag gattacatgt tatattgccg tacatcacat cataatagtc 312540 cactgtctat atcttttaca atggtcctct attgcctaaa atataagact ccaaagccct 312600 atgcatggat aatacaatcc gcctatcatg atatagcttc tgatacttct tcagcctaat 312660 ttcccatcac atcccatatt ttagtgcggg ttccttgaag ctaccattca ctttattcca 312720 cctaatttgt atcatgtggt gtcccctcta ctaaaatgct tttcttcttc tagcatacct 312780 attccaaagg actcttcatc tgtggagcat tcttaactca cccacatggg tcctgtgaga 312840 tcataatacc tcataccttt ctctactacc acgttggtca catctgtttg cttagtaaac 312900 aagtaacatg aatgaagaag gccaggagta aaaatataga gagaagtgaa gactggaaaa 312960 ctggagaaca tctttatctt atttgaagtg gcccataacc cttcagctct acttcatggc 313020 agggacattt tattttcttc catatagacc taatattttg caaatagtaa gtatctaata 313080 catgttcgta gaagacataa aaagttattt ttttccttta ataattaagc tacttttttc 313140 ctactgaatg ggcattactc agattgcctg ccaatggttc ttcaagtgtg agaccatcag 313200 catcaccttg caatgtgttt gaagtgcaag ttcttgggcc ctacaccaga acaactgatt 313260 cggaaacaca gaaattcacc aagctgtgtt ttaacaaaca cttcaggtca ttctgatgcc 313320 caagaaggta tgaaaaccat ggtctaggtt aatgaatgtt tagctagaac tataaaaata 313380 aattttaagt gaaaataaat gtaagaaata acctaaaatt tctgaagtat cttatagtaa 313440 tttttaaagt gtactttttc atttaatctt attaaggatt aaaggatatc cattatcttt 313500 gaaaagatta aaattacact ttccaaatca aagaggattt tacttttacg cttactaaaa 313560 ttttgaattt ttctaaaagc ttcaactgaa gctaagccta accacacaaa atatagttga 313620 taatttagac aattatctag ctaatttaaa ccattaaaat tttattcata tgctttggac 313680 tcaatactct agataattga cacataaaat acacatttgc ctcaatagct acattacttc 313740 ctcaaatttg tatctcagtt tttagacctc aagctaagga acaaagaaat tttccataga 313800 gctggtttat aagagggctt ttacagtgtt tttactattc tccactggag ctgaaagtca 313860 ttctttattt tgaagatgaa gagctgcaat agtaatatag tttcccattc agtaagcatt 313920 actatagaaa caatctcttt ttcagattaa tttagttaaa ggttttatac tgtaactaat 313980 gtttactatt ctcatgtatt tggaagtttc ctctttttaa agattaaatt tgacatagaa 314040 aaaggaaaca tggcatggtt gcaaaaaaga aatctgagga aaatttactc agagttgcaa 314100 aaaattttat gtcatgtgcc tctcccaccc cccaggattt gaacatcgta tctatttcta 314160 agatcaagaa aattgccagt agttgaaaat gttgcgggaa gtcagggacc ccgaacggag 314220 ggaccggctg aagccatggc agaagaacgt ggattgtgaa gatttcatgg acatttatta 314280 gttcctcaaa ttaatacttt tataatttct tacgcctgtc tttactgcaa tctctgaaca 314340 taaattgtga agatttcatg gacacttatc acttccccaa tcaatatcct tgtgatttcc 314400 tatgcctgtc tttactttaa tctcttaatc ccatcatctt cataagctga ggaggatgta 314460 tgtccgctta ggacgctgtg atgattgtgt taactgcaca aattgtttgt agagcatgtg 314520 tgtttgaaca atatgaaatc tgggtacctt gaagaaagaa caggataaca acaatgttca 314580 gggaacaaga gagataacct taaactctga ccgccggtga gccaggcgga acagagccat 314640 atttctcttc tttcaaaagc aaatgggaga aatatcactg aattcttttt ctcagcaagg 314700 aacatccctg agaaacagaa tgcatccctg agtgtaggcc tctgaaatgg ctgcttcggg 314760 ggggcggcgt cttttatggt cgaagctgta gggatgaaat aagccccagt ctcccgtagc 314820 gctcccaggc ttattaggac gaggaaattc ccgtctaata aattttggtc agaccagttg 314880 tctgctctca aaccctgtct cctgataaga tgttatcaat gacaatgagt gcccgaaact 314940 tcactagcaa ttttaatttc acctcggtcc tgtggtcctg tgatcttgcc ctgcctccat 315000 ttgccttgtg atatcttatt accttgtgaa gcatgtgatc tctgtgaccc acaccctatt 315060 cgtacactcc ctgcccttct gaaaatcact aataaaaact tgctggtttt acagctcagg 315120 gggcatcacg gaaacctgcc aacatgtgat gtctccccct ggacacccag ctttaaaatt 315180 tctctttttg tactctgtcc ctttatttct cagactggcc gacacttagg gaaaatagaa 315240 aagaatctat gtgaaatatt gggggtgaat ttcacccgat atctggctga atttcccccg 315300 atagagtaaa atacattatt tattcattaa catggatgtt aatgaatgcc caaattggta 315360 taaccacacc agagagcccc catgtgagta tcatttggaa gattgtgtta cctagcaaca 315420 cccaatcagg gacagtccct attcatacat acatacagca tttgggtaat tggtgtctgt 315480 accatttgtg tttggaacag tccatcaaga gagtgtctgt ttatgtgatg actacatgat 315540 catccatgct caattttggt taagatgtta tcactttcac aggacttgaa tggacttttt 315600 aatttgacat ttacaaaatg aagaaatcta tcaaaaagaa agtatgggta ttgcatgcat 315660 tgatttatta agctgttatt ttaagcacat agaaacttaa ttaggtgtat attatgctgc 315720 tgtgtttgct ttcattccca atcccctctc actgagagat tttaacccta agaggctgaa 315780 atcagtccac catcttgtcc tgtcttctgc cctatctccc ttatccaaat tcatgtttct 315840 ggcttctttg ctcttgtgat gacccagcca gatcacaagc agtgtccctc agatattgtc 315900 aacatttgca aacatgttta cgggaatgct gttttgctgc tgcagctcct gtaattgttc 315960 tcaagccttg ctacagcact gacttcctcc aacctccact tcctgccttt aactcataac 316020 ttacagattc caatttggtc ctatcctcac tgcttactat aagatcttgc tttttctttg 316080 gtatcctaat accctaggaa atgtcacagg attcttagtc tttcatggca ttaccgatcg 316140 gatctgctcc tttaaagaac ctcatatcta gcttcaagtt tactaggtca gtggactccc 316200 tggtgatctt ttgttatcac tgacaccagg cctgcgctgg ctacagtggc ccatttgtca 316260 cccactaatc agggtagcca cttggctaaa actgagttca cattgaatga taatctttcc 316320 cggtctagct gctatctaca tcattctttg acaatattct gagttgttct accagctcat 316380 aggcaacgtc atataccttc ctacatatgt aggagtagga gtaggagaga ctcatgtcct 316440 tgcaggatcc ctctatgaaa attttcttcc taaaaagaaa aggcagctat gttagtcatt 316500 atctctgttt atcccaccac atttttcttc tctctctgat tcaggagtaa aagtcgtgtt 316560 tctctgcaaa tccagggtta tgtggttgga gaaaattctc acactgattt taaggcttca 316620 aatttaatgt cgggcttgta agtactctga cattagaagg atacacagat accaattcac 316680 acatccttat tttgtgtgat aatagctgat tgtaggctta attcagatca taatttttca 316740 ggccaaaaga tggctatatt tctctctctg tactggacac tgtggcccta agcccagaca 316800 tcttccttag ggctgagaca gcccagctgc tggaaatacc agctgttcca ggtacactgc 316860 tgcccctccc tggaaattgt agtttaaggc aggaaactac cttatccagc attatggcct 316920 ttgccgtggt gtggctataa ccagtgactc gtagatacag ggatgcaaag gccaggtacc 316980 ctggcttcaa tttggcagaa ttctgaaggg gctatccctg catttgagct ccaggaggac 317040 tggccgatgc ttcagctcca tttgaaaatc agtttaactt cttcttctta atcctgtctt 317100 tttaatagcc ataacccatg agagtactcc ctcaataagc cttttcacaa tctactttca 317160 ggaatccaat ctaagatacc ctcccaccac cccaaccctt tgtgagggga cagatctctg 317220 cttatgacct ttacaacaaa ccttacttta ctccccatac agatcctctc ctatttcatc 317280 atggtgtcta atttgcttga ctacttgaac ttaagtttcc ctctactttt cagtccataa 317340 ttcaacctag cagaaccaag caggaataaa actgcttcta attatattta attgggtttt 317400 tgcagtaaaa atatgacata atcaaggttc taagaattta tagaaatgat gaaaaattga 317460 gtgaaggaga tgattggaaa tttgcagttg tattgtgaga aaaatcaatg attgaaagta 317520 gatggataat tttgcagaga ttttttgttt ttccacaaga aaatgattgt ttctaatatc 317580 cctatatgta gtcttaagtt agaagaattg gttgaagtca aaagtgggtg tcatagtttt 317640 cttccaaact gtaatagatg agaatcaatt cacacaggaa agaagtaggg agagagagag 317700 agagagagaa agagggagag aatatagtag cagcagatgg atgaggtctt ctcaaactgg 317760 aaaagtttag taaagccaat ttttgaagcc ccattaccat aggaaatagg ttataaatgt 317820 agttgttatc attgtaattt tatgagaaat gtgactagca catatatgta agcaaataaa 317880 ttgaaaacta aaagggaata tcaagaatca actaatctta ggggatctta ggggaggtca 317940 atgttgaagg gctttggtgg gagaagggtg agttagttat tcaacttctg aaatcataag 318000 caaaattgtg tgtatgcatt tatctatatt tatttcaaag agaaatcagg attttcatta 318060 gattctcatg tagatattta tgacccaaga aaacaccaaa ccttgggtaa aactaaaatt 318120 aatcacggaa actgctgttt tgtgctaacc tgacgtgaat tttctgcatg aatttggcaa 318180 aatatttaac atttttgcat gtatagatta aagtgataat tatagacttt tcacagagaa 318240 agatgatggg actatctatg ttttcttggt taagaaccaa aaagttgtta gttacatatg 318300 ccaggattga tgaagatgca gcctctaaat ttatattcag catcttcaca aaaatgacat 318360 gtcctgagaa agacattata gtagtagtta attataacta ctataattat attcatgcat 318420 attaacaact atatgccttc ttagatgaaa aggatgtgtt taaacaaatt tataatcatg 318480 taagcagttt accagtactt gtaattcttt ctggaaatgt gtaaaagtat gtgcaaaact 318540 ttattctgtt tctcttattt cacatttatt gagcattata gtaaataggt taaatagtat 318600 ctattttaat tattcaagtt agaaatcaaa tataataaaa tctgaagact taacttacaa 318660 ggatgatttt cagtgttaag atccataaca ggattacact catctatgtt ttatatttca 318720 tgcctgaaag tgctaacatt gagcaaaatt ctcaatgtgc attctttccg gatgaactgc 318780 agttagacaa ctaaatctgt aatgcaatat aacatggtcc tattaaccta gtgatgcaga 318840 aaagaccatc tgtaccacac tggatatgac taaactatag gaataaacta aatgcctatg 318900 tggtaattaa tttaagaaag ccagtgaatt gttttttaaa ggaggagtgt aaagtaaatg 318960 atgaaaaatt aataaaagta gtcattgact ttcaatgcat cgtaataagc ttgcagaatt 319020 gatttgtaaa ctgctttaaa actcaatttc atgtgcatta aagactaatc aaatgacttc 319080 gatgcagttc actgattttc aacttggcaa ttacttgagc atataaaagt tattagtaga 319140 gatatgtaag aatgcttgca aaacagttgt cacgatgcac tgttacttaa tcttatttgc 319200 gcagattggt tactcttatc tttgtcttat taatccagag tttaatgttg aatgtactcg 319260 tggtttgtct gcacattgtc atgtctttta ccatagagag aagtagtaga atgatggtta 319320 ccagaggata ggaagggtag cagggtacgg ggtgggggat aaagtgggga taggtaatag 319380 gcaccaaaat gtagttagat acaaggaatt agatcttgtg tttggtagca ctttagagca 319440 acaatagtta acaataattt aacaaatatt tcaaaataac taaaagagta gaattggaat 319500 gtttctgaca caaaaaatga taaatgcttg agatgatgca tatcccaatt acactgattt 319560 gatcattaca caatgtattc ttgcatcaaa atatcacatg cacttcataa atatgtacaa 319620 ctctatatcc ataataatta ataataaaaa tgtttagttc tattgcaatg atttgtgtca 319680 ctattaactg ctagaccaca aatgaaagct tataataata aagtggcctt cttaaattct 319740 caaattttct gtaacaggtg ttttacataa atttcatcaa tgagttaaat caagtagaga 319800 ggacgtggta tagagttcac cattttccat gaactattga gttctactca atcaacattt 319860 tttgttaaat atcagtcagt acaattccag gaggttaaga ttctctaatt attatggcca 319920 aagcaattaa atattctagt tttcctacag tcaaaattga gcacattctg agttcagttt 319980 agaatctgtt tgtgaaaatt catttaccat gccaagtcat tcagtcagag ctgggactca 320040 atgctaagta agcaaaatag cctggggccc tgcccttctg aggcctatgg gccagtcatg 320100 gaaaaaatgt taaacagaaa atcaacaagt gcataattat taactgtggt gaaagctatg 320160 aaaggggtgg taacctgttc agaaggaagg aaaagcttac ccatgaaatc actttggtgc 320220 taaaatctaa aggatgagct cagtaggtga agtaaaaagg atcaaacaga aagaagccat 320280 gaatctgaaa gaagcacaga cctcaagggg aattaaaatt ccatatgact ggattctaga 320340 gagcaaagaa cagagatgaa gctgcaggat ggagagagtt ttgtcttcca tccccaaaga 320400 gaaagttatt ggtagcaggg gagcacaggg gaagggtgga attgtgcaat agtttacata 320460 atcatatatt aatttttctt tctttagaga tagggtctct ctctgtcact taggctggag 320520 tgcagtggct caatcatagc taactgtagc ctcaaactca taggctcaat ctatcctccc 320580 actgcagcct cccgactggc tcggactaca ggcatatgcc accataccta gttttttttg 320640 ttgttgttgt ttttttatag agatgggggt tcttgctatg ttgcccagat tcatctcaaa 320700 tgcctgacct caagagatca ttatgccttt tcttcacgaa gtgctggcat tacaggcata 320760 agccactgtg cccatcttct gaattttttt aaagataaaa attattattt ttaagggtgg 320820 acaataatgg tacaaatgtg aagagtgata gcattttctt gcaagaaatt atgtgaacca 320880 gtatagtagc gtggaaatat gtaggaacag tgaagatgag agaaatgaaa acagatattc 320940 aggaggtgaa atcaatacaa ttaagggatt gatattaatg gaatattggg gatgagtgga 321000 agagagagaa cagtatctag aatggtcctc aagtctcagg cttatatgac tggatggatt 321060 gtgatgccat tcactaaaaa aaaaaaaaaa aaaaaaaaag cctgggcttg gagggtcaga 321120 ttatgaaact ggacttgtta taagattgta aggtgtcttt caagtggaga tgttgatgaa 321180 tctattagat atacaataca ggtttggaac acagaggaga ggtctgggct ggagataaat 321240 atttaggagt cattggagtg aagacagaat taaatatgtg catgtagaaa aaaaccatcc 321300 actgggagag tatactcaaa atggagaaat gttcatgagt tttgagagtg ttcttccatg 321360 ttttagaagc atcttcagtg cattgaggaa aagttcataa taaatatatt aaagataatg 321420 gtgtctatga catttaaata atataagaag gtagttaata ttgcagccca aagatttaag 321480 ttgactgacc ataaggtcag tgtgtaattg taaagccatg gataatgtgg acctagacta 321540 ctgtgggaac aataaaaatg acaatctttg cattttcttg taaatcatac ttagagaagc 321600 tttgggttac agattattgt ttggatactt tctcctatgt ttttatgttc tttgaggagt 321660 ggaagtttta ctgtattagt ttttttagtt tataaacaaa ttcatgcttg acataaaaaa 321720 agatacataa agaagaatgc atacattata tctcccttct tccaaaccca cccactgagc 321780 tagtcaacat taaaagtttg aagcttttat gcaacatata tgaacaaata taagcttttg 321840 tttttttgat gaaaattatg tgaacacatg gagtttaaac ttgctttttt tacttaacgt 321900 tatatttgag caacctttta aagaatatca taggattcca aataataaaa atgccataat 321960 ttattcagta attctccttc taatggataa tccaattttt tctagttttt atgcctttgc 322020 aatatcccat atgtggatta ctgagtcaaa ataaatgtat atgttttttc actttaatag 322080 atattgtcca aagactttcc aaagagtttg cagcaatctg caatcccacc gccaaaatgt 322140 cagaatgctc cccagcattc tttgccagca ctagatgtta tgctttcttt catttactgc 322200 aaaattgaag actagaaaaa ttatatcctc ttgtattact ttgcagtttt tactactagt 322260 gagtttatat acctaacaat taaagtttaa tattttaatg ttatatttat tagttaatat 322320 tttaattttt aacatctgct ctttaaagtt tgtatttact tgtccttctg tgcatcagcc 322380 actctgagat atacataaca ttatatgcca tactatccaa ttttggagca aaaaaaaaaa 322440 aaaacagaaa acaggaaaaa gaaatcttta ccagtacagt acatcgctct ttaaaaccaa 322500 aagtctttaa gaattccaga tggaatgata aacctctcat acacagttga ccccactttt 322560 cccacccaaa ctcgactcac aatattattc aatacaaata ttctaaatat gcaaggtcta 322620 ttctttacct cacctcactt ccttcctgcc tgttccaaca cattagctcc ccatcaccca 322680 tacatgtatg taggctatac tcactcctgt gtctatccct ggacttatga tgccttagat 322740 catatattct taaaactctg ttcatccttc aatttcccta gaaaagtgga tgtatagtgg 322800 atgaatgttt ttattttatt aaaactaaaa gtctcatgtc atcaaaatac ttttatgtca 322860 ctgatgtgga tctaatcatc agaaatatga taaaattatg tactgttttc ttgctattta 322920 tatcatactt cacattggtc tcagagaagt tttctacaat atcctctatt ccaactataa 322980 ccattgattc aaaattattt ttacatggtg tttaaatatg agtcaacaat gtttgttttt 323040 gttacaggat atatcatttg ccttataata atgctctctc ctgtctccat ttatagggaa 323100 attttttggg ttcaaattcc ctggtctgag agttctcact tacagaaagc agtccttacc 323160 acaagaagac cccgatgtgg tggtcatcga ttcatctaaa cacagtgatg attcagtagc 323220 catgaagcat tttaagtctc ctacaaaaga aagctgcagc ccctctgaag cagatgacac 323280 aaaagctttg atacagccca gcaaatgttc tcccttggtg aatatatccg gacctcttga 323340 ccattcctct cccaaaaggc aatgggaccg actctaccct gacatgctgc agtcaagttc 323400 ccagctgtcc cattccagat caagggaaag cttatgtagt atacggagag catcttcggt 323460 ccatgatata gaaggattcg gcgtccaccc caagaacata tttagagacc gacatgccag 323520 cgaaggtatg tttgattttt ttttaaatgg aaacatatat taatgggtaa taaatgatta 323580 tttgcatatt gtttgaaatt tcaacaataa tctctgtgca ttggggaaag aaatgtgatt 323640 aaaggctatt aaaaacctga gtcctacact cagagttgtt actgatttcc tctttgaacc 323700 cttgtgagta atttagtgtc ttctggcttc tttatctgta tttctgaaat agtatgataa 323760 ccattatctg cctaccacat ggagtgttaa ttaattaatg cttattataa catgtgctta 323820 ggtaatgaac actatcatct caagcatagt taattttgct gcatttagca aatgatcatg 323880 ccctgggaag aaagaatttg tgccatcaga gggctagttc attgaccgac tctttccaaa 323940 gggagcagca taggaactgt gatgtactga gtgatcagaa agctgtaagc tgacaggggt 324000 gcaaggtagg taggatgaag gggaaaaatt taaagggaaa aaaatcctga aagtcctgat 324060 ctcaacaaaa atcgacttga aaagcaaatc agaatttatt ctccctggcc tctttgaaca 324120 ttatgttcac attcttacat tagccagtag tgaaattaag gatccttaaa aaaagcagtg 324180 gcagaaacta tttatcatga acatggtaat tgataacatc ggttaagtac ttactgtgtc 324240 tgaggcaatg taagtgcttg atacacattg tctcatttta ctctcataag aaacccaaat 324300 taggaatcat ttctaagccc tatttagtaa gtgaggaaac agaggcttaa ctatgttaaa 324360 taaataacat aaataactag actaaggtta cagagctagt cagtgtcaga gcccggcttc 324420 aaactcagga ctgcctgtct ccatagtcta caatcaaatc catgcaatct ttttcctccc 324480 tcactcctgc tcctccatga aaccttgcca taggaggagt ctgttgaaac tcttgacttt 324540 ccccagggag tccaagaatc aaagttcctg gcatgggtac atcagacccg ctttccagat 324600 tcccatagat ttggttcttg agagacctgc tgtccaggct actgctagtt ttgtctttaa 324660 aacattaatt cttaatgtga ggtgttaggc actttgtcag ctgatcacac ttatttttct 324720 agcctcattt ctagccccag caagactccc ctccctatta catactctat tctacatctg 324780 cacagatata atttgccttt tcccaaaaat gtaacacgtg ttttcttgct tcattacttt 324840 gttattcctg gaatactctt ccctgctttg tctctcctta cactaccact cagcagcagg 324900 gacccatttc ccccttccca aaccagaaga attaaatcat ttcacactcg agtgtgcaaa 324960 ccaatattta catatagtgt agcatggatt gcattttata tttattgtgt attatatgtc 325020 tgtcattctt gtcagatatg taagcaagca attatgttgc tgtgagcgcc tccagcatag 325080 gcactctggc atagtgagct ctgcaccctt agtttctagc acaattgtct acttcatggc 325140 agatacgcga taaatattgg tgtaacattg agaagaccat gtgatgttga ggggactgtg 325200 cttgcgagtt ctgtttcaaa atcatgcaga tcagaaaata atgagttatc tgctccatca 325260 tactctgaag ttaaacgaag tcttaggagt aaatcatata gaggatcttt atctaaagga 325320 caccatgaag tagagaaggc agaagaggtg aaaggaagag ttggcaggaa gaagttcaaa 325380 gaaagataaa tcaatagctc agaaaaagat acaagagcaa ttagcacatc tattttaatc 325440 tgtgggccaa agaaggtcaa aaggaaaaaa gaaaatacaa ggccaattcc caaattggat 325500 aatcatctaa ggccatatcc catttagtaa tggcaggctc aatatttcct gacagaatga 325560 aaccgctaga atttgatctt tgatcagtga gtcctgtggc taaacagcaa caataaattc 325620 aatatggtaa ttcaaatgac cagcatatgt tttagtgagt ttagttagtg tagtcacttt 325680 tagcaatcat actgactttt cagaaattgc ctttcagaga ttcccctaga gagatccctg 325740 acttataaca gtagtatagt aaaattcaaa aaacaacaaa tttgaaaatc aaactgatac 325800 ataatcagtg cattttactg acttagcctg tgtttggaca gtggtgctga gtagtttaga 325860 ttagatttct tgatttaact tcattgtttt taatttatat gatatccatt tagtgcacag 325920 ttactgatac aattatgaga aagaatgatt taatattttt ggatttctca gtacgggtgc 325980 tatacataaa catttggtgc taagatcatc ctcgattttt ccccctcacc caaagtaagc 326040 tgttataaaa aaaaattact ttcttacaga ttatgctaga gtcaacatgt gactatagat 326100 tgataaattc agagggtatt ttctacttca tctttaaaga aattttagct acaaaatcac 326160 tgattagcaa aaaagaaact acattcccta agactttata atttggtata ttttagaaat 326220 agagccattg ataaggaaag atggaaaact tttagaagtg attttagttt tatgaattca 326280 tgtaactgat taacaggtga aatcatgcac aagatttcga agttgggttg ttgtctcctc 326340 attgaaataa ataaaaatgt tctcctgtac aggctatctt cacagaactt taaatatttt 326400 gcagatatat taatgaataa tattttacct tatcctctca tttaatccac attatcaaga 326460 accttagaac catacttttc aaaccatctt tgatgaagaa ccagaatttt gttttctaat 326520 tcatcactga ccaatacatt tgtgaagcca ataaaaatgt actactggaa aaataaaatg 326580 taaaaaatag acataaaata taaaccccaa ttgttttatt attagattaa tcagacatga 326640 aattactctg ccaaactgct acaaaagatt ctaaatattt actccaattt ctgtacttgc 326700 attgtcatgg aagaataaca agcagatctc agctaagacc agtgcacaag ccacactctg 326760 ccttggaagg tcaaagctgt aataactata taatgtaatg ttttgttagt tttcttggaa 326820 ttggtaaatc tttacatata atttttaggt ttgataagta cagttataat ttataactac 326880 ttgcaagcag ttgttacttt actaatggtt tttggaccca gcttctgaca gacacattca 326940 ttctgagtaa tcaagatctc ttccactatc tctatttgtt tcttgtaatt ctctcaaaga 327000 ggaaagggag ttgtcatcta aggccacagt tttatttgta tatctttgtc caatgcaatg 327060 tctacgagca attcaatata tcacattatt agaattattt cagttgtaag ctttgaaatt 327120 attatgatat atcccaagat tttaaatggg cacagtgtta gcatagatat caacaaaatg 327180 ctgaacagat ttttcaaatc ttggatatat ttgaatggtt ttgatatgac agtgacgttt 327240 attttaagca agtgtgtttc atagctagta atgcatattt tgttagtggc aagtatgcaa 327300 catttagata gctgatctca aagtaaatct gaaaatattt aacttagatt ttaaaagagc 327360 ccattttatt acaaataaaa tttttcaata ttctagtaat tacactgaat tcattgtgac 327420 aacattaaca aaaatgttta cattttttaa aacaatctaa tctttcattt acttcttgca 327480 attatttttg cctaagaatg actctttgag ttatatttgc tatttttaaa atatatattg 327540 aagtacattt ggaggagggc agttaataaa attgtgatta ataatgtaag ttggagctag 327600 gcagagtgga gccaggcaga ctggtgtggt tgtagtccca gctactaagg aggctcaggc 327660 acgaggattc ttgagcctag aagttcaagt ccatccagag agatatagcc agaccttgtc 327720 ctgaaaggaa gaaaggaagg aaggaaggaa agaaggaagg aaggaaggaa ggaaggaagg 327780 aaggaaggag ggagggaagg agagaaggaa ggaaggaagg aaggaaggaa agaaggaggg 327840 aaggaaggaa agaaggaagg agggaaggag agaaggaagg aaggaaggaa ggaaggaaag 327900 aaggagggaa ggagggaagg aaggaaagaa ggaaggaaag aaggaaggag ggaaggaggg 327960 aaggaaggag ggaaggaggg aaggagggaa ggaaggaggg aaagagggaa gggagaaagg 328020 gaggaaggca ggagggaagg agggaaggga ggaagggaag gaaggaggga gggagggagg 328080 gaaagaaggg agggagggag ggaggaaggg aaggaactgt tatcttagaa acattttcct 328140 tattaacata ctaggttaaa ttatatgcaa aaaaacactt aacatgcaaa atgtggagtc 328200 ttcctttgag tatattctaa gtgatagttg aggagacact aaaattggct gttgacaagg 328260 ttgaaagttt tgtcacaact gcagcagctg gggaagtcta tttccaaact gtcataatta 328320 taaaatctgt actttggaat ccatttaaat tgagataaat gcttcacata tttaaataag 328380 aatgtatatt atgacagata ctatttttag tatatgcatg ttacttggtg gaatagtaca 328440 aaatgttaat ttcaattaaa gagaaatttt ccatcatatt ctgatttctc tgattgtttt 328500 tatacaggta attcagtgta tataatataa ttttagtctt ctttttatat ttctcttttt 328560 ttatccttat gtgctcaaaa cagacaatgg tcgcaatgtc aaaggtaatg tacaaactca 328620 aatttcacca tctgatgttc aacctgcccc tttactcggc atgttaactt gcctgctgta 328680 tgccctgttc agtgcaacat cttcatgctg cccttagcta tttggggtgc ctggtggaga 328740 catcatggct tgattttgct acagacattg ttatttctct gctgtgttac caaaatgatc 328800 atgagctcct tttgcctgca agaattataa gcctaggttg acaatgaata cttcctaaat 328860 atttaaatca cttggaaaaa cacaaatatc aagctaaata tattctgatg tgacagaggc 328920 acaaaagcct atttcaggaa aacaaaaaat ttgagtgcaa gattaaataa aataagcaaa 328980 gtgctacatg acagcatcac ttcacttgtt cctcttttgt ttcctcaaaa ctagtttcac 329040 gttcctggat ggcagggggt atggttttca gcttactgta gtagtaaact atatatgcat 329100 gacagttgtt ttctattttt ctctattata ttttaatcat tttaattttg ttctctatta 329160 gtctgaaatc actggcatga cctacaacta ccatagggtt atatttaact gggaatactc 329220 tggataaatt tggattgggc tgaaaatttg gaattcaatt ctgttttcta ctatatcata 329280 gtagatacaa ggatcacaaa atatgataac catattatta tcatcaaatt gaaaaccatt 329340 gggatttggt ctttcaacat aggccatgca tgctgctgtg ggtgtgcaaa tggtgattgt 329400 gacttatttt gtgcatgtgt gttgcatgaa cacgtctcca ccagtaaccg tcattactta 329460 gaattcactg ttttgaccac tctctcctat atgtcactgg tacactgacc actgtgcaat 329520 tttgtatatt gatttctcaa ttgcttccct aaaataattc agagctggtg atggttatga 329580 attaatagcg ctagggagca aaaatgtttg gtcagcaacc tagggaaatt tgaaaatcag 329640 ggaaattatg gcagtatccc cccaaaccca ccccaatttt attttgtagg cactttaaaa 329700 gggtctatgc aggttgaccc caatagtggg atgggatttc acctacatca ttgttctttt 329760 tttttttttt ttttttgacc tgtccactgt gatttctaaa agggagcaaa ttagtgtcaa 329820 ctgtgtgtgg tggtttgcat tgacataatt cagaatgtaa cctcaagaag caggatacag 329880 atagttcttg ccaactagct ttaggattta acaattagca gtaaattagt aggcattaat 329940 taattttcta gtgattttta aatgtagtga taaatgaacc taatttttct caacaaatag 330000 aaaattggac ttgtttaact ttcaaactac tagttcacat atatgtcaaa gtacagctat 330060 tttattttag tgtcataaaa caattcattt actctccaac ctttttttct caactctctc 330120 atttttaata ggagtagtct ttgaacacgg atattcttta tttattacat agatttcaga 330180 ttgctcatca attttacgat cacaatttaa agtatatggt agaatcatca aagtcagaat 330240 ttggcattac aaatctctaa accattgcac aaagttttca catattaata cttaagaagt 330300 tatatcccca aattggagaa aacatttgca aacttaatta aatttaatgt aaattttcaa 330360 tccaaagtct tcattacgtt tttcaagctc tggttttgaa aactattaac aatgtttaag 330420 tgtctgcctc taagattttt cacaaagcca ttaacattgc taattaggta caagaacccc 330480 caagtgtgca ttttaaattc ttttgacttt gcttctatac cagatctaaa taaaaaacta 330540 aaaaatgcag gtttctacac tgctttgtgt acaaaatgca taattataat taattatttc 330600 aatattcaac caaaaaacat tttttggttg aatttaattc taattattta attctgaatt 330660 aaataaataa cgtaggaatg tgttggtaat gtcttcaata tcatctgatt tattcatgtc 330720 aggtgaggta ttggctaaat accttgcaca ggtggtacat ttatctccag aggatgccat 330780 tctttaactt tctcgggaag tccgtgttag tgcctgttac acaaagagct aacctaaatc 330840 cttctttctg atatgtattc ttttcccctt catctgtctc tactggacag agatactagc 330900 tgactactgc taatcatgat gcaatatcac agtaaaaaga cagcaaattg gtactctttt 330960 ttctaaaact aatttccact taatcttctt tcttaggatc tatttcgttt ccctttaata 331020 aattttctta gcattatgac tccttaagct aacatttcaa agttctttgt taaaaatgta 331080 aaccattgtg aaagagtgga aaagttattt caaataaatt gcacatcctg catatacata 331140 tgtatgtatt ataatttttt aacaacttct ctaatatgtg agaggggtac ctaatcctac 331200 ctccatcact catatattaa tttttacctc caacttggtg gcttttctat tttgctttac 331260 aagtcatcag taaaaatcta cctcactttc tctacttcgt aaataagtca taatacaatt 331320 ttgccccttt aatgctccca cctccttgct atctcaagta accctgcttc cctctgacat 331380 tggtgtgttc catttccaat tagtctatga atctgtcata tgattctgaa gtaaaactac 331440 tttcaaggtt tgttacagct tttatctcct ctctagccta tatgactcat aaacaaaata 331500 aatgaatcta atacaacttg tttctcatag gctgcattgg ccattaccca gtatcttgtc 331560 atctgataag gatttgcaaa ttgattttca atgataacag tttactcctg caaataatat 331620 gtcatgcact gaaacagaca atatgaagaa aaataatttg atgattactt cttatgcatt 331680 tttctaagtg ctaaactggt tgccttatac ttattgatag tgttctttta caaagtttaa 331740 ttattaaaca ctgcatttgc atcttctttc atgttaagtc acttgaggaa tttgggtttt 331800 attaaacttt agctaaataa actcagtgcc ctaagatata ttgtacaaat acctgatgat 331860 ttaaaaacaa cctttgtctg tttggtttcc ttctttccta tcacatttgg ccctccaaaa 331920 tgatttttta aagtagcatt atttttttaa tctatcagat gcccttagct atatttccag 331980 caccatctaa aagaaaaaca tattctcctt tagcatctca taactcatga taaatttaaa 332040 tagcctcatc gtataaattt taaatatctt taaaattctt cccagttgtt gctttagcct 332100 ctagcttcat gtctaaatgt aggtatttct ttgtagttgg aaattggcct actttatgtt 332160 taatcagacc cttgaaatat attaaagcac tctccagctg ttggtttagt ctacttggtt 332220 acctgttttc caccttctcc taatatattg aaaaatgtaa cctggtcatc catcttgcaa 332280 atgcttctct gaagaacatc aagtccacct ctatgcttct gcgttttaca tgactttcta 332340 ctgaatctct tatttccctc tatttctgcc cattcatttc ctttaaattt atttactttg 332400 tttttcaggt tattctcctt tctttcatta gaatcctaaa tcccatctgt tcatgatcac 332460 tctcagtgag gctgcctttc acctttaaat cctcaaccaa ggcctctctg aatatagact 332520 taggaggtag gaaaccctgc attctggtcc tttattctta ttcttttctg gcctcatatt 332580 ctgtccactt aggtttacaa tcggtgaaat aaggatattg ttaataccta ccttagttaa 332640 aatgttgaaa tttttttcat ttgcatttag atgggcttag aggaatctaa gccaacactg 332700 atcatcttga agactctaga agtcttctgc atttaaacat ctgctttaaa atccgtagaa 332760 agaagcataa ttatcttttt tatacagcag gaaataaatt ttaaatgcct tatctaagta 332820 gcttgcacaa gttattttaa gtaatatttt aagttttgct gaattaatta aaatatagat 332880 taaaagaaaa tgtggattaa ctatttaaga ctaagagcca aaaaaaaaaa cccagaatag 332940 aataagagtt tagaaggttt ttctacctgc aaataagaga agctaaaata gtgaatgcaa 333000 tgaagttgca aattctgagg ccaaatttga gtatgacatt ttatcaacca gtttctcaat 333060 catatcagat ccaatgtctc cttgtctcat attttgttat actcattttc ctatcctgaa 333120 atggaactca gagataattt aacctatttc taaaatatca acatgattcc ctaactgtaa 333180 tatacaggag aaataaaaga aaaacagttt acaataaaat atttatttca atatgttagt 333240 gttcaaatat aacttcacta gaaaacataa cacaataatc agacatatga agaaaacttg 333300 gttttaaaag cgttaagtac atgagaaagt attccataca ggtaccagat aaaatggtac 333360 agcaggagta taagtgggca gcataatcaa aactaccatt gaagtcaaga attatatcag 333420 acttatttat acatgaattt taaaaatggg aagtaactaa aatttaatta tgattaatat 333480 accaatataa actgaagaga aaataaggaa gtatggtatt cttataaatg agctagttct 333540 tgcttttaat agtagtgtca aaatgatacc ttctgtgata taatgcaata gtagtgaatt 333600 gcacagaaga aagaaatccc actagatgtc aggacatgta ttcatcctct aatacattag 333660 aaaagatcct gcaaacatgc tttgttatgt aatgagaaat tgaagatgga atggaaaatg 333720 aaatggcaat tgagacatta tagagaagtt gtggcagatc tccagggagt tttgagaatg 333780 agactgaaaa ccaacagcca acccaaagac aaataataat tacaagtgtt tcatttttaa 333840 gagataggtt ccttttcata gtatgatatc attttacata cataggaaga tatttatata 333900 aaatattttt gaaggaactt ttattagtgt gattttggta attctttgaa aatttaataa 333960 tatttggttc caacactggt aaagaagact caaatctctt agcttacata tttgcaaata 334020 acagctccaa acacagattg taaactaaac tctgaaatat tctattggct actcaaatgc 334080 catgaggagt gtagctctaa gtgacataat cttccaaaat gatgaacaat ttctgataaa 334140 gttctgaata aaacaatata tattcttacc tctacatgga aattgtagct ctggaaattt 334200 caatttatat taaaatcatg taaaaagcac attgtggtgt ttatatgtga aacagttagt 334260 tttaaagctc agttcatgaa taaacaggct tttcacctgc atgaatggcc tcgaggcatg 334320 taaggcaatt ctttaaggca ggcgaattgt gacattgaaa ttctttcata attgtgacaa 334380 caaaaaatgc ccccacaaat ctcccctaga atgaaatact accatagttg aaatcacatg 334440 cttatataag tgtagccaat tcagaggagt ttattggcac tggtcacaag ggcaattaaa 334500 gtggattaac agtgtctttc tgtctattaa cattgtagaa tcggtgatga catcgatgat 334560 ccgtgaattt agccaaattt taaataactc tgtggacaat ttgctacaga aatgcagcat 334620 agagaaggat gataaaaaaa gagagtggaa agatgagctt aagggctttt gaatacaatt 334680 taactatata tttgatctct gttatctata atctcttaat agtatccctg ttagttaaat 334740 aacctaagga ttgaaaatag gacattagag ttggggaaaa gacaatatct aagaaatctg 334800 aaatcctagc ataatttaca aactgtaaat attaagatat aaaacctaga actcaactat 334860 agaatgctgc agaaagggaa acactatcct ggtatgcatt acaataaaat aaattagtga 334920 tgtgggctgg agacttccaa aaagacctga agaacggagt ttctgtcaga gaactatctg 334980 aaggctagat gagtttgttg ccactattgg ctcttatttc tatctttgta taaatagtaa 335040 agagagttag gttctatatg caaatgagaa catatgaggc aataaattcc tggagagctc 335100 gtgacatttt tcttctagat ggacttggtc atcgtcatgg ataagactca gggagtcaac 335160 agaaatgcaa ctcaagaaac acagtatttg ttaaatacat gaaaatttat taagattact 335220 tcaaactttt ataataaaca agtgtaaact tttatgaaca agtatagtgt gattttcccc 335280 catagtgact atgaacaaaa tgatgagcat tgatttctta gtattatatc tgacccaggt 335340 tgattgatta ttgtccaaaa tgcaaaatct taaagtctaa tttttaagtg tttatacctt 335400 gcttgatgct taaagtacat tttgatcccg aaaatgggtt cacgtcattt tgaacaggga 335460 aaaaaataac aaaggcaact atgctgccta acaagtttat tgatggaatt tgtatgtttt 335520 aaccacttcc tggggcacaa aaatagggag ctcacgattt ttataaaatt ctccctgttg 335580 ttaattttta agagctaaat aacagtgtac gtaatattgc tcattacacg agatacttct 335640 cagagaattt cctgattctc cataagcaac agacaacaga ttcatcccaa aggaagatac 335700 agctggtcag tctactccct caacaaagaa accaggagtc ttgccacctt gccaagttat 335760 ctttgtagga aagattttga gaagcgacta ggtactatca accccaggca tgccctatta 335820 cctagctgtg gtcacttgta ttgtaagtta tgtttgccag agcattagtc ttttgcggtt 335880 tttaatagcg cctttttttt ttctcagaaa gtggtcaaga cttaaacata agtgaaagaa 335940 aaaaaaggat ctaaaaatcc cacatatgat ccaagagttt tcaatagagt acacacattc 336000 acacaaaaat ggcctttcac cctctgcagc tttatctgta attccttcat ctgggtttaa 336060 ctctttcaga agctctgtgg agtatctcat ataggtagtg gaaacatatg aagagcctag 336120 atggcttgtc actcctcagt gacacagaca ggggagtaac acaaattgga gcagggtaaa 336180 caatccattt ggaaatttca tggccaatat gactttaacc ataggtaagt ccttcttaaa 336240 taatcctcaa attacaaaat gaaatttata agaaacttta aaggtagaat ttgaccagta 336300 acagagagtg tagttttttc ttttattcta gcttttaatg aaagaaacta attaacagct 336360 aaatctgcca tttgctctct gggtacacac ttagaaccca gtcttattct cagatactca 336420 catgccattc catgtggccc aaggtgaccc taagccctgt gtccaggtat aagctggctg 336480 cattcagtca cactcaaatc aggatcatat tggtcaggaa tcattagcag ggcattcaga 336540 actgtctctt tcttctatat cttcttatat tactcttaca aatactttcc atttttttag 336600 ggccttttaa tcatatcaag tcaagcctcc tgggatccac atcagattca aacctcaaca 336660 aatacagcac cattaacaag attccacagc tcactctgaa tttttcagag gtcaaaactg 336720 agaaaaagaa ttcatcacct ccttcttcag ataaaaccat tattgcaccc aaggttaaag 336780 atcgaacaca caatgtgact gagaaagtga cccaggtagg acacaatttt cttatcaatt 336840 tcaactgttt tagaggtttg tttctgcacc atgaaacata ttctttttct tataaatgac 336900 tgtcggtaga ggtaagacat tttttctttg tactcctatt tatcttgaga tgttgggtaa 336960 ctctctaata taacagatta ataaagctgt atactatgat tttatatatt acaagactaa 337020 gcaaaaatgg gctaacatgg catggttgct cccactttcg tagaggtggt taacctgcta 337080 ttcgtcgtgt ttggacactt agtgtttggc tgccaactct cacattatta aaacatggtt 337140 ttttaatata atggatgtgt ctattgaagc tttaggggac taattagcat ttgctctgaa 337200 ctgtggtatc cttttggact tactctacta aatagagtca gatctaagtc agttaacttg 337260 gggaaaagag ctgtctgaga tgatgaaaag tcagtggaac accacatttt attggaacaa 337320 tatctaattg ttttcaaata aatactgcaa cttgaactag gatgaaaagc tagcaggtat 337380 actgcttcag agagtagata aaaatgattt ctacttatta tatcaatata ccaacctaag 337440 cagtacgtag cttttgctta cagtgcactt acattgttgg gaattcatga ctttaaaatt 337500 tgtcaagcaa gcggttcttt tacaaacaat ttactcggta tatttgctta gcaaatcttt 337560 gcataaactc tctataatat aaagccaagc ttgcccccat tctttatccc aagcattgaa 337620 gtttttgaat taatgaagtt tttctgtaat tgtaatcact acaaaccaca ctatagtact 337680 gtttccagat aacctcttat gtgtgagctg aaatagctat gaaaagacca tgagcaagtt 337740 ataaataaac ctgtgcagtc tatatttatt tgagatgaga aattatacac gccattcttg 337800 agagcatttt ttctatatat tttaatattt atgtagtgaa gaggctttct tttcttggca 337860 tttcactttt cttaacttat atttagtaaa atgggtaaat gaacagttta ctgttacgca 337920 cattttattg acatcatttt gatagctttg tgttttcctt tcaattgttt ttactttaaa 337980 agtattatta tttatagatt cctaccatta tatgaatata taggaatcaa gagacttaag 338040 aggagacaga agaaaagttg gaaatattag gatcagggcc ctgcaagtgc ataagggaat 338100 aaaatttaaa gagaagcaca gcatggcaat ggggactgtg gcgaactgtg gagtgcaggc 338160 cccatctaaa gcagacagct gatatgcagc tctgtctaac tgcggttagg cagaaatgct 338220 tgaccaatta atgaatgctt gcaaatcttt ccattttaaa agagaagctg gaaatgcaga 338280 atttaagata acctctttat ttcttaaagt tgacaaatga aaaaatgcct tgaactcttt 338340 tttaggctga acaaaacaca tcttaaggcc tgtgtgcagc catgtgggat ctcagcaagt 338400 ctttcatgtg cttggtccac cacagaggcc accctatgct gccgtgttca gcagatccac 338460 tgtgccagga gaacatgata cacacagaga tctgagaagc acctgctctg ggggctttct 338520 cagatagtgg gacaggaagc atatatataa atatcaataa tgaaatgcat ggtaataaag 338580 aatattaggg agaaagttat tctactataa gggaagaatt tgcagggaag aaaaagacag 338640 gattaaacat ttaagccaga tctagaaggt cacatcaaac tgcgtagtca gtaaatttta 338700 agagcataaa tcagagtcaa acgggattgt gttttatttc aggcatttat tgtaggccat 338760 gaatgcaagt ggcatttatt gtgtgacatt aaggcaaatt tcaggactgg gaaaccttac 338820 ttctcagagt tgatataaga attaaataga aatgtggaaa gtgtccatcc tagtactacg 338880 taccataaca agcaatgtca tgtcattatt atgtttatta atattcttct atgatccccc 338940 aactctcttc attatctctg caggatctct ttatccctac atcacgaggg ccttagtaga 339000 acacctggca gaatggagtt catcaaatgt ttgctgaata aatgagtgca taaatggatg 339060 gaagagttag ccaagggaag ggataagaat tccaggtaga aaaaaacaca agaacaaagt 339120 tatgaaagca gtaaagtcca tatgactttt tagaacaagt ggttttctga gctggcgaga 339180 ggctagtctg gaaaatttac cttcaaaata acacttttct accttttcac ataagtgcca 339240 tgggggtttg agtaaaatgc aacagtttcc atcaaaagct ttgcattttt tttggtctca 339300 cactttatct ttaaaagccc tgtgactttc aaatttagct ttgtaatata gaaatatttg 339360 ttttaacatt taaaaatctt ttaaaatatt attatagacc taatgtttgt gtacccacca 339420 aaatttatgt gttgaaacat aatcaccagc atgatggcat ttggaggtgg gacctttcag 339480 aataggtcat gagtgtggag atctcataaa tgggattagt gtccttgtaa aagaggcccc 339540 agagagctct ttggccccct tctgcactgt gaggttacaa tgaaaagatg gagcttattt 339600 atgaacaagg aagcaagccc tcatcaggca ttaaataggc tggcaacttg atcttggact 339660 tcacagccgc cataactgtg gacaatacat ttctcttgtt tgtaagctac ccagttgatg 339720 agtattttat tttagcagcc caaatggact aagatgacta cttaccactg agtgaatctg 339780 aggcccacag aaagacccca gagttttcct aaagcttctt atgcttccca caaattgtgg 339840 agtatccccc tcccactctc caaagtaccc caactggaga ggtatgatac aggcaaaagc 339900 ctttttcaaa ctgctggaag atcagaattt gatcatattt tataaaagtt ctctcttttt 339960 ttacagtgta aaaaatacaa tgaatgggag gaaattctgg agtcaggtga aacacttaag 340020 ttgctatggt ccttgctaga aataataagg gactgaataa aggctgagac cagaaactgg 340080 gaaaaaaggc atcagtagga atgctttatc ttctttgtag gggccccttt tagctcttag 340140 tgacaaacct tccaattgtc cacatgtcaa accaaacaat gtagagatca aatatcaaga 340200 acttcctcct gcaggcatag cctctggaaa ttttatttaa gcacttgaaa gcagagctct 340260 tcaataactc atttatagga ttacatactt cattttgtat ttgtgaagtt tcctaattgc 340320 agctatcttt gaaatttcca tattcactac ttttaacatt agttgtcctc tggtcaccaa 340380 aaacaactta gtaataacca aaagacttta cttgtctttt tattttcttt aggcctgcat 340440 ggagattctc tttgtcagga aattttcaac atgtttgctg taggcagcca gcagtatttc 340500 cttaatccaa tgttctttct tattttattc acgtaataga tttgtatgat atttctttct 340560 tcaaaagaag tcaagatttt gcttatagat tattcaacaa taaattttaa acactctaca 340620 gtgcacaaac aatagagtag tcatcaagag aaaaaggcat tgatgaaaag aataatcgct 340680 gctcctgttg ttctgtctca ccacttggat cttatctcta ttacacgtta aattagaatt 340740 aggcaattag ttatttacct cctcagttag agtcatcttc ttcaacacag ggactatgtg 340800 gtcattcatt cattcattcg ttggtcattc atgtatttgt ttattcattc aaaagcatgt 340860 attgacatgt attatatata atatataata tatacattat atactatata ctatatatta 340920 catgttatgt gtatatataa tatacatatt atgtgtgtat atataatata catgttatat 340980 attatatgtg ctgaatataa tacatacata catagtatgt gtatatgtaa catacatatt 341040 atatattata ttgtatataa catgtaatgt atataatata tgtattgtat ataacatata 341100 aatgtatatc aatatgtata ttatatataa tgtataatat atatccatat ataatgtata 341160 aacacacaca gtgctaggtg ctgggaattc agaattaaaa ggcaaatctc tgcctttgag 341220 tctcgaagga agtagagaag tacagtacat tgactttaca gtgcaatgta aagtattttt 341280 ctatgggtaa acactgtgtg tgcagatggt gctgagagag gaaaccttag ctacattggg 341340 agtttgggat agtgtttggg gaatataaac ccttaagtgc gttttgaagg tgagaagttt 341400 ccaaaataag gaataaaaat ctggagtgaa acacatgtgg gaatctctag gtaccaaaga 341460 atgaatgcag catgaggtgt ttgtatgacc agtgcctggt atgattatat gacacatagt 341520 agcatcttaa atgattcaaa tgaaccactg agggtattgc gtgggattaa gcaagagtaa 341580 gtctgcagtc aaaaatctcc aaagcaaatg ccttccttct gaaatctttt gttaggcaag 341640 acttcaattc ttgctgttat tttggatcca tagtcctctt ttggccttat tggtcttctg 341700 gaatgcatca tgtcatattt cattttgcca tatttcatct caccttcttt atttatttgg 341760 agaaaagaga aaataattct cagaagatgt gtgtgttttt tttcctgcac tacagtccag 341820 ccagtaaagg ctgatgtgca gtagtgtaca tctcagggag gcaagccctt ggctggccat 341880 ttctaccaaa ttccaatgga gtggtggaga gtaaacaatg aattgtaaga aaatttgggc 341940 ggagaacaaa ggtaaggtct ccttttacca agcagttgca cttctcaatt gaagatcaaa 342000 ttatggctat atttgccccc tttaaataaa agtgaaccac acttttgcac tattctaaga 342060 ttttgttatt cctgaggcta gtttagttca aatattgtgc caatttttag gatgaaacat 342120 attattttgt tgccatattc agctttgaca agttttgtat tagaccactc tccctggata 342180 agtatgagta tccgaatagt taaagaagat ggtgccgtgg atttcaaatc tttattggcc 342240 attgtatcag tcaatactgt aacagaatgc aagtaacaga aatccaactc aaaccacttt 342300 aagcaaaaaa atgaaaggaa gaggggaagt ttattgggcc atattactga aaggtacaga 342360 gaaagatctg ctttggggtg agctatatac atttttgtgt aactagtgac attctctccc 342420 ttgcttctgt gttgactgca ctccccacct aatagcagca agttcctcag actctcctgt 342480 ctcacctaat gctcacagtt agtaatttgg ggagaaggac cttctttctt ccagtgtcca 342540 tattattccc agaaaaagaa gactcttatt gaccatcttg ggccatgtga tcatcttgtg 342600 gaggaaaaag tatagtccct tgactgacag tcacaccaga aaaatgcaga gggagaagca 342660 agcctgtaaa gcaggagaat caaacagcag tggcccattg cagagatgaa gataggaatt 342720 caaattaaca gcattaacca cacacacgtg cacaccccca ccctcccccc cacacacaca 342780 gagtccacat tgggcagtgg gtagattcta gaaacacaga aatataaaac ctagtataga 342840 tactcaagac attataaatt acttggagaa acactaccat accagtatat agcatttaca 342900 catgctaatt attaaattaa attaaattaa attaaattaa attaaattaa attaaatgct 342960 acaaggccat attatgaaag taacaatagt ttacatttcc tttaaactta gtatttgtcg 343020 tactatgacc aaatagttct ataagttggc ctttattaca taagaggaat gtctggtgaa 343080 ttcagtggaa acccattttg agataatcag gaaataagat gtgtgaaggg accttaatga 343140 gccagaaggt attaatctgt ggaacagaag atgagaaaaa atttactact agtccacaag 343200 tataattttc ctgtagcttt actaaggaaa gtactcaaga aaattagttc agatttaatc 343260 acaaaataac ttaggtcaca agaaagaaat ttctgaatat taaaaaagcc atataatctt 343320 taagtctatg tagactttag agccataata gattcccaac atttaggatt catgtaagta 343380 tattattggc atgaaaatag aattatggta actttcatga tttctgacat tgattgagca 343440 tttaatatgt gccaggctca gtggtaaatg gtttagtgga ttctcaattt taatctgtat 343500 gacagcactg tgagattgtg ccgttattat ccatatgcat ttcatagaga agaaattaag 343560 cttagagagt ggaggcaact tgcttaggtc ttatagtaaa tgatggacgt agccttcaaa 343620 ctgaggtaat ttgattccaa aagtgaagtt ctcattctct aaaatatatc ctctttatga 343680 ttctgttctg tttccccatt tgtcccctaa atctcctcag gagttactgt ggcagttgga 343740 catacttgta acatttgact gtgacaccaa atgtcctaat ctgagtggtt agttaactct 343800 tcaaaaagcc tacaaagcta tcattgccat ggaggttcat ttccagcacg gtctcttgtt 343860 taaatttata taccatctac tttatgctga tttcagatta gaatagtggg atgggggttt 343920 ttgttggtcg tatgctgcac agttacagaa aaagcaaaac caccctgata ttactgactt 343980 aaagaagaac tgaaagatta tggcctttta cttatattga actttgttca ttatgaacag 344040 gttcattatc tcttcattgt gactcagtgt ttctcaattt atgcttattt ttgacataaa 344100 tccaaaacaa gtatttatga tttagtactt ctttaggaat gcaggctgat ttgtaatgaa 344160 gaaattttaa tgaggaaata acattgactt tttcttctta gctaatgttt aaaattattt 344220 gtcatctcag gcttaagagt acaaagtttc tcccatccaa gtactaacca ggaccaactc 344280 tgttgcattt ctgagatcag atgagatcac atgtactcag ggtggtatgg ccgtagatat 344340 tagtacaaaa tatcttaaca tgttctgtag tttccttcaa attggataaa tttagtcctg 344400 aatttcttca atgacatgat ttgaaaagtc tttcagtata caacaacaaa caaaaagtgg 344460 ttttatatat agcagtactt ttcaataata atttcatggt tttaaaatta tacttaaggc 344520 aaattttcaa caattatttg tataaagact cattgattct tcactcttga aattactaaa 344580 aacaaaattc acaatactga tgcaggattt tttgctcctt agctcagcta ggtctgggtt 344640 cttgtctcat gaccaggaaa aagtaggcac atggatactc aaagaatgag tggagtagaa 344700 ttttttaagt gaaaggaaag ctctcagcaa agagagaggg gctctgaaag cgggttccca 344760 gtttcccccc ttctcagttg aatacaaagg cttctatata tctaagctga tggggctggg 344820 ttccatattt gtataaggca tgaattccag gtggctcccc tccatccccc cagtgcgcat 344880 gcgggccctt agtccactgc aggcatgctt aagagaactg tgtaagttct cttatctgca 344940 caaaacatct ggtgtcagca cttgtggggc tggtcacagg ttctctgggg acctttcctt 345000 actgtctgcc taaagaaagc taactccttt cattcccttc ttcaggagtg gagaccccca 345060 acggctgttg gggaaagtag acaatcacca ttctaaactg cttcctgctg acagggagtt 345120 ctgttttggg aaagtggcag ttagggctcc tcctgaggtc tgtttaaggg tccatggaag 345180 aatggcacat ccatgcatgg tttcatttgc atcgccattt gaagtttaat ggccttttag 345240 caagaagaag caatttgggt tatcagaagc tgtaaatcaa aatgaatcaa gggagtaagg 345300 acagctccac aatcccaaga ttgctgacat gcccagataa ctggtggcta tagttatccc 345360 tgctaagatt tggatgcatg gggcttagct ttggttgact cccttggtct tattttccca 345420 aacaaaaaaa cctccaggat ttgcaggata attgcccaga attaaaatat tgatccagat 345480 ttttacatta tccatccctt ttgtttcttc tgagctgcag ctgggtatca ctggtttgtt 345540 cacaggaata agcaggatta gtctaaaatg ttggcaaaag cttgaaaaca actgatgaga 345600 ttagaatgga atcacaagtg tatgttaagt tttgaaacaa tttttctctc tccagtcctc 345660 atttttgtca aaaacaaatc atgataggac tgagttcttt gtaaaataaa cttaagtctt 345720 atacttggct tgattatctg cataaagtac agcaagaata gttatattta acataggctt 345780 ttaaattggc tttaatagaa ctctgttcta caaggaatct cagataagac cttttaaagc 345840 ctagcccagc catggatttg tactctgaaa tacctatgat ttgggcaaat tcctctcttc 345900 ttgaggtccc cagaacatag ggctcctggg cctgttagaa agtgacattc tttactcacc 345960 acaggttagg aaccctgtac agggactctt tagacaaggt atgaggccaa agttcctaag 346020 gagctttaat tggttctgca ggtcatgctt gattccttaa agggaagcac atccttccag 346080 tcaaagcctt ggtaaaacaa ccagtttctc caattgtgac ctgttataaa aagataatgg 346140 attcttactg cactgatgca aataaatata ttgccgtaag ttaagaatac tcacaaatag 346200 tttacaaatt ctggagaagc caggcagaaa gaaacaaata tgctcaaaat tttgttcaca 346260 ggagtatagc ttactcaatt attaaaggct ctaaatagtt caaaataaat ttccttgact 346320 ctgaaaaaca aaacaaggat caacaacatt ttaagtaaaa agttaaatga ttaattcagt 346380 tttctattag ttcagtccat tcagttaact cttgttctgc ttgatattca tgagcatttc 346440 agctctttat gagtcccata tgcttccctc tattccaatg ccacaatctc caaagatatc 346500 agaaacttgt gtttcagagc tcctgtccaa gtcctatatc tgattataaa ccattttttg 346560 gaaaggatca aagcaagaca acaattgtct gtgaatgaca aaatacccag gatagttaca 346620 gtcaaaaaca tgattgacaa agaaatttgg ttatttctgt agtttacaat aggttaacat 346680 aataaccttt attatgattg atagcatgta ctcagacatt agaattttag acatcccata 346740 caattttgga acatatacac ttattgttca ctaaaatata acctaaagaa gataaaacat 346800 cactttggaa ataactaaaa atgtcaaata atcctgttta cctatctttt ggatgctcca 346860 ggggccctct ctagcatcta aaagttaggg gtcaggaaag acaacattga aactgaagtt 346920 tgattttgtg aagcctacca aaagagtaaa ggttcacaac acttgatatt atgaaataga 346980 attccagatt accctaagtt atttagccaa aatcatgact caaaaatttt aagaaagacc 347040 aaaaacctct tattatcctt tactattaca tgaaaatctt gttcaagaga cagaaagcca 347100 aattttaccc ttgcattagt ctactattaa tatcaacccc aatttttaaa tgaaacctta 347160 aacataattc tatctcatct taaccagttt gaccttgcag tgagattctt gtaaaccttt 347220 tataaccctt tacaaatctt tgttaaataa cagatcaata ccttaagaaa accttgtcgt 347280 gcttttattt caatactcag tttatggaaa aactatatag tacctttttg aagttggtca 347340 atatgttcac acacagaatt tcttttgcaa gattcttttt tacaaatctt ccaccatttg 347400 tttaaacctt cagctttatc ttttctattt caaaactatt ctctaaccct aagcaaaaat 347460 ttacattctc atgccttctt ataacctttt actaaaaacg cattttactt tccttacaca 347520 gcttgtatat aaatctattt tcagtagtct caattacatg ttatgatggc aactcttagc 347580 aatttttaat tttagtgtaa aacctggtaa gttattttaa ttatgtacta ggcacagata 347640 agatctgact ccagcatagt tagtgacgtg gttaattcca tatgtcccta ggccttacca 347700 aattgtaaag caggcaagtt gagcagttct caaaggctaa agaagcagct tataacctta 347760 aaacatttag caaacctagt atctgacctg catactttag accacatatt tatattttga 347820 agacatttgt attttaccaa taatctttaa gacttttatt tctcaaagat taaagtcaca 347880 tgaactaaaa ggcattatag cttttatttt tccttcaaaa aatatttgat ctaagtgctt 347940 atttttcttt aagccaatta attagagctc tatttctata taaccatcac acatctaaca 348000 catatatgat tacacagaca gaagaagatc caatagttgt aagaattttc atttgcctat 348060 ctcctaattg aaattactgg actcagggta tagctctcca agaagcaggg ctagggaaac 348120 atgtagtttc ccaggccaaa aagcaggcat acctggaaga caaaaacaaa ttttgagagg 348180 gacctatttg cttttaattc ctggggttcc atgaggaaaa caaatatttt tttcccaaaa 348240 tggagtctgt ggcaccttct ctgtttttcc ccaggcatcc caggccatca gaagttatct 348300 tagggcctct gacttgtgca ttaagagtgg caagacaaaa tggagaaaag taatacagtt 348360 gactgagaaa aaaacctttt ccaaaaaaaa aaaaaaaaaa aaaaaaaaaa ccaagatcca 348420 agaagagaaa aacatagagt ccttttagat atatctatag cttggagatc catttttaat 348480 taaattgagt acactttaag gaaatccttt taaattcctt attacctgat tttagccatg 348540 caaagcggcc aatatttctg gcttttgagc tttaccaaaa ttaatctcac aggtgaagcc 348600 aataagcctc aactaaggtt atgacttaac cttagtgttc aaggtgttca atgtattttc 348660 agaggtggaa aacagttttt acaaaatctg gaatctttat aggtagctca gggaagggaa 348720 gatttaagaa aggaagctag aagttgttca tggaggggaa gataatcacc aaatggtaaa 348780 aagtcacaaa ggtattaacc agaaagtact cattccctaa gccaggattg ataccatgtg 348840 gccattaaaa tggcaaagac caaaagagag tactgccacg tggttacaag gtcaagcccc 348900 caaagacata aaacaagatg cagacttgca gcaaagtttg ttactgacca atttgctagg 348960 ctggcttaaa cagcaggctt atgggagact aggcccacgt tctagcctga agtacccctc 349020 tttatgacag aaccatacag aaagacacac aaagtgcacc agattggcta cagcttaaga 349080 caaggcacaa atcctttttt ccattaatca aaactttaca gaggatataa gcagtaattt 349140 tatcattcat tcaactggtt tgcacaggga gagggaggcc agaagtctga ctggtaagaa 349200 cttttgccct tttcggggca tgtcaggctt ctgggttccc ttcccctgag ctcatttaag 349260 ctaagcagtt taaagtttgg ggatcttaac ttttccccat ttgaggatgc atctaaggga 349320 agtgtcctgt agtacaggac acaattaccc atccacgaag agaagacaga gttcgaggaa 349380 aaagaaggct ttttttcccc aaaggaatcc cagtgattca ggaggcattt gagagaagta 349440 cagactgaag atgaatggct acccatctag aaagagggga aaaaggcatc cctaggtcct 349500 ttctcttcct agcaaatacc tggggtacgt gagggagaga aataatggtg tcccattctt 349560 tcttctgtcc ttatatcccc gagtcctggc aacctcggca gggtgccacc catgaatgcc 349620 aatgcaactt ttcacccatg ttaacaggga ggcctaatgg gtgggaatta tccacattta 349680 cctacacgca gactccttcc tgctgttggt aacttttgag ttccctatac cttgtctgtg 349740 tcatagatac tagcatgacc tctatctatg aaatgggagg gggcctaatt gtcaggaatc 349800 agtcatgcta aggtaaagct gtggagctgg gtccccctca aacaagggag aggaaaggga 349860 gtcccgtgaa ttggggtcct ggcctagtaa aatgcctctc aaaggaaaca aaaaaacctc 349920 ttgcatagaa aagctgccca tatccgcagg gctgtgttaa ctcctggcac tgtgggaaaa 349980 agaaaaataa acagtttaag tgcagggtgg ggacaatgcc tgggggaaaa acctctagct 350040 ctatgcaaat gtgtttctcc accagggaga gaaactctta atctttgtac cctcttggct 350100 caaccagagg aggaaaggct ccacaggttc atggcaggat gggtcggaga gtgggaaatg 350160 ctggccaaca ggctgcatga gggccttggc ccccgagatt gccttggtac ccgggaagca 350220 gccacagctt attcctgtcc tgcgtggtca ctgaacgcag catatgtgtg tggcagacac 350280 agccatgtac cccagctggg aggggaggtt ggagcaggga gtgcatacct gtggccattg 350340 ggtggagctg agggatgcct ctaagaacag atggaaatca cattatcctg aattgcatat 350400 ctggtggctt ggccaaatgc tcattctaca tagtaatatc tctgcagttt gcagcagcac 350460 ccttaacatc atttaaaaag aggtgccatg acagccctga aaaagaaaga aaatgccata 350520 gaaaagtctg gattgcaaag aggctgacat tcccaagccc tgagagtgat gggcaggggt 350580 gttgttgggg tcctatctag catcctgtcc tctgtagctg cgccatttat tcttaattgg 350640 ctcacaagag gtttggtgct gcatcagcct tcagaaaaag tctgaggact agaagtctca 350700 gaagtgaaag tgaaaggttt tgggtctcat ttactcaccc tccaggcatc ctgtgcgagc 350760 tcccaaaatg acacaggatt tcttgctctt tagctcagct aggtctggct tcttgtctta 350820 caaccaggaa gaagtaggca tgcggaggct tgaagagtga gtggagtaga atttattaag 350880 tgaaaggaaa gctctcagca aaaagagaaa tcctgaaagt aggttcctgg ttgccctcct 350940 tttcagttga atacaagggc ttctatatat ctaagctgat ggggctgggt tccctgtttg 351000 cataaggcac taattcccgg tggctccacc taatccccct agtgcacatg tggcccctta 351060 ggccactgcg ggcatgtttg ggcaatcttc ctgtgcaaat tcccttgtct gcacaaaaca 351120 tctggtgtaa gaacttgtgg ggcaggttgg tggttctcca gggaccctcc ccttactgtc 351180 tgcctaaagc aagctggcta acttctttcc atacctctag agtatgatta acgtgttctc 351240 ctaaacttca ttttggatct aaaccaactt atatatcata taaacctcaa taaaactata 351300 ttgaattcat cttgaattgc caaataatgg taatcacaaa attccagatt aaatttggga 351360 tgtaatgcag gagtacaaaa ttgcttctga gcaattccaa tttaatagaa cattaatttt 351420 gcttccatta tcttgttgtt atttatagaa taccagcaag cttggttcag caaaacagaa 351480 attcctatcc aatgtttttc ccatattctg agtttagtct gtaaataata tttaaatacg 351540 caaattgaaa tgacaatata tctggaagct ataagaattg tcattagggt aattatggat 351600 tcaatatttg tcattgtttg ctaaatataa gtcaaatgtt atgtactctg gctgatataa 351660 aaacatgtaa ataagatcat tgtcttcaag ggcctttgat taaatagaga ctttgagttt 351720 tgagatctta gattatgttt tctagtcgtc tctggtcaaa taaatatatt ctattatcta 351780 gtccaagctt gtatagccct cagcccgtga gctgcatgtg ggtcaggatg actttgaatg 351840 tgacccagac aaatttgtaa actttcttag aacattatga gatttttttg catttttttt 351900 ttagctcatc ggctatcatt agtgttagtg tacttaatgt gtggcccaaa acaattattc 351960 ttcttccagt gtggcccaga gaagccaaaa tattggacat ccctgattct ggtcaatgat 352020 gaggaaaaaa taaaaacatt ttacaagcta ttgactactt caagcatgtt gtatgctacg 352080 tatataataa atacaaaata agagtgtgtg tttcttgaaa ggagaagtgt ggaattttta 352140 attaagcagc aaattagttt tctattttta ctaaatgcta tatgcatatc aatacaatca 352200 cataatgaca tatattctaa attaaaatgt tatttcagtt taaaataccg aattagctag 352260 gtaattaata agtgtgaaaa atcacacttc tgtgtattct agatgatgaa ggaataacat 352320 atctatatga aatcctggta gccaactgac taagcaccgt agcttgaagg ggaagcattt 352380 atgtgtaatt ctgttaaaaa gcacctgttg ggttttatat gttcgttatg ccgggcaagg 352440 tgtcggagcc ctggcactgg gaagtggtcg actcatgggt tggtaaaaag aattactggc 352500 aacagtataa gtttgaaaag ggaaagttta ttagaaagga agaacactgc aaaacagtgc 352560 agtggggcac ctcagtgaga ggactgagcg cagatttttc ttttgggata tttatggacc 352620 ttatggtggg agtgtaggat tgtaaaatga gtttcagcat ggcattccag agatgtatag 352680 aaagttttgt tacttataag cttttaggag ggaaagagat ctggaacaag atgcctgctt 352740 ttgataatgg gaaagtctaa ttacttctaa ttttccccag ataaggagtt ttgcctctgg 352800 atggcctgat tgatggtggt ctttgctacc ttctaaattc ctcagataag gagtttttgt 352860 atctgaggca tgttcaatga tcaccaagtg atttttgctc ttctcacatc acacatttta 352920 aagctaaggg aagaaaaaaa atatcatatc ctttaaaagt tctgttggac aaaaaatcag 352980 gttgaaagta gctgcttgaa gtaaagaagt aaaatacaaa tggtcagaag aggtaaaatt 353040 aggtaaaatt taacttggct tgagtacctg gtaatagcct ggttgctttg gcaactaaga 353100 ccttggaaag attgttgata tctgttgtca agatggctca ggtctttctt caccagttgt 353160 tgtcaatctt gagataaaag tcagacccag gaacagaaaa gaagcacagg gagagagttt 353220 ctctgctcct ttgccctcct ggcctgaggg ttgggacaaa cacatagttc aaggtgggtt 353280 gcctaatgag agtgagctaa agcagtacat attccatgta tcagagagca agaattaggc 353340 agaggacatt tatcacagaa aaattccgta gcagacgtgg cattttcaca catccaagca 353400 gcctaaggcc ttgtaagctt cattgactac agctattccc tgagttagga agtgaattcc 353460 aacttgggaa cttatttaga aagaaatccc atatagaaag gtaaaataac ataaaaggtc 353520 tcattgatta tctgggtgtg agattgtggg taatacattt tccccctcta gctctatttc 353580 tctgtatttt gcagatctca tttataatgg aaaaatatgc agttagataa taaaccctct 353640 agaactcaat tgtttctaaa gagttcatta aaaagcattt catcttcaca ggattttaaa 353700 attcaaagga gccttagata tcatcttcct cagggtttct caaaatttcc tgatcaatgg 353760 aatcatctgg aacacactct ccctctccct cctccccact caccccccac caaaattaaa 353820 tatatcagtg gagcctgaga atcttgaagt ttttaaaaac tccattccat ttgtgacctc 353880 ttctgccaca ttattaagat caggcaaact tggaaaatat aaatatagca caaccttttc 353940 attctgtagt tgaagaagct caaaagataa tccagcaaag acttgtgttt tatatttctt 354000 taattgctat tgcaagttat gtctctttct gtagatttct taatgattaa ctagttcaga 354060 tgtatgtttt tgtgatattt taatcataag atttatgtta aaagtgaagg catatgaatt 354120 cgtattaaca cgatcatact ggagaaacaa gcttactttc attgggtagc tactgagacc 354180 agagggcagc tactgtcata ttgaatgatt gtaaaagttc tctaagaaag aatctccctt 354240 taagagaact tacctaggcc agagtcctct aaactatctt ccttgcagaa tacttgtctc 354300 ccaaggatgt cccagaagaa atattttctt agttcaaaca gtaacccttc cagaaattaa 354360 tgtgaaaaat tagcatgttt aaggttctaa aaattcctga attaaataag tctataaaac 354420 attgatttac caatatatct caaacttttt tcatgacaga acccattttt aattatgttt 354480 gtttgttgat actagacatc cattgatatt ctgaggaatt aatatggggg tgatttttta 354540 ggatatacat tttcatagat aactgtgggc tatatgtgca actcaaacat gaatatgtta 354600 gaaattttaa aactctttaa aagaaaagct tgagatagac atggggtaat agtgactgga 354660 ttaggaataa gtgcgtaata ggaatatttt ttcctatttt ttctccttgt tttaatgaag 354720 ctcacatagg tttctttttc aaccatgtcc caaatataga acttagctta aaggaactaa 354780 agaaatgcca catatatttc tttttctact ttaaatatac ctgttccaag tccacctgtg 354840 ttttgaagcc tatcttttaa aaatcattta gctagaaagg gaaaaatgtg ggctgcagag 354900 taatggagaa aagaattaaa gaacccaaat ctccctgctg ggagggactg tagttaaagc 354960 tgatccccta ccacatttat agtccaaaga attgaaaatg gagagccttc cttttctgcc 355020 ccctcatcct aatgagctga ggttgttggt agcaaggatg tcactttaat ggcccaggta 355080 gaggtgaagt ggcctatggt gtgaggagaa ccagaatata accgtggtct ttttcacact 355140 ttcttggctc ctctcttttc tcttgctcat ccagttcttt tctgatgtgg caggaaaaat 355200 atcgcataat ggtctgcaac cagatctact tcctgcttcc tattgaccct ttttacattt 355260 gaactgaaga gtcaagctga caaatttctg tgccattatc agcaacacag tcttaatttt 355320 cagatcaagg aaataaagtt cagtgagatt gagtgagttg agtcaaaagg gaaaaaaagg 355380 atgtaataga gaaaaatatt gctctatact gctctttcct ggttgactgg cagctgtcag 355440 ttgagctgta ccatcctgtt tcggggtgat aagctgtcat ttgtaaatta tgcccacagg 355500 tatatccatt attcatgggt ttttattgga aaataatgat ttcaggccct taaattttcc 355560 tacctgcagg cacctgaatt actgctaaaa ttgattgctg tattagttct catacattct 355620 ctctccctct ctttttctta ctacgttcag aatctaccaa ctcactttgt gttttcaata 355680 aagaaagact tctcttccct tcctatattt ccttctatag aaatgaatga agagtttctg 355740 acgtgtagag tttcctttaa ttttagcaac tggacactgc aagtatgaga gttcagtata 355800 aagttacctg aagcaaaagt attttctaaa taacaagtat tacttctttc cactttacat 355860 aacttattac ttgaaagcaa ttaaaaacta aggcgtaaac ctaatgagta ttaaaaagag 355920 aaagattatt atcacatttt tatatttaga tatcaataat gaattaaaat aacccctcag 355980 cttggacttc tgattagtaa ttttaagatt ttgaatatgt ttctcatgta gattccccca 356040 aatttgtttg cattttgaaa gcaaactgtt atagatcact aaggtagaga agcgaaaaaa 356100 ttaacatgaa gaaaagttga aggtctcacc tttgaggtaa ttttgttcca ttctgaatct 356160 ttaaactttt ttgtttgctt atttgtgtgt ttgcttaaaa tcagagaaaa caacagagac 356220 acagattcct tagttcctgt tttcttttca tgtgtcttaa tctgtttcgt gtggctctaa 356280 aggaatacct gaggctgggt aaattatttt aaaaaaattt attcgctcat gattctggat 356340 ggctggaaag ttcaagattg ggcatctgca tctggtgagg gcctcaggct gcttccactc 356400 gtgatggaag gcgaagagga gccaacatgc acagagatca catggtgaga gaggaagcaa 356460 cagagacaaa gggaggtgcc aggatctttt taacaatcag ctctcatggg aatgaataga 356520 gcaagaattc actcattacc atgaggttgg caccaggcca ttcatgaggg atctgccccc 356580 atgacccaaa cacctcccat taggccccac cttcaacact ggggatcaaa tttcaaaatg 356640 aattttaggg ggacaaatat ccaaactgta gtacagtgta atgatcttct gtacatgttt 356700 aactgccaaa aatgaattgt tgcacattgt atgaataagt taggatgcat cctgacttat 356760 tgcggtctct ctggtttctt caccacatta ttattgtagc aattttggag gaaaacttcc 356820 ttaagagcat atgaaactgt cttaaagcaa ttgtttgaat agttttgaaa cttgtgctcc 356880 ttagcataca ggatgctgaa aaggagaatg gggaccaagg agacacagca ttgagacctg 356940 tacacttccc cagattcaac gaactcgctt cattttatgt ggctttatat attggctttc 357000 tcttaagact gtgtgtgtgt gtctctctgt gtgtgtgtgt gtgtgtgtgt gtgtgttgaa 357060 agactcaact tgtttaggtc aggcaccctc aataaatttg gtctagttct gctatttatt 357120 ctgagcttcc caatatcaaa actgcttaga tattttcact aattctagtc atccaagttc 357180 ttatttttat agtgattttg agttaaggga actttccaga gtcctacaaa tagtaaactg 357240 cacacccaag actggaaccc taatttctgg actctgactc cagtgctctt tccacttggc 357300 acttccattt gaaagcaagg ccattttaat ccctgtatgc tctgtttttc acctaaggtg 357360 gatgactgac aaaatttcaa cagctttgta gcctgactcc tcctagtctc aatcctcttc 357420 tctacaagat aaatgcttta agaaatacag ggttgctagc agaagtgagt tttcataact 357480 agttaaaacc aagtagttga acaagatatt ttgggaagat gaaaatttta ctacctgact 357540 caagaaaatt aactccatag gaaagcaaat aattttttaa cacagtaatg aaaatttaga 357600 gggttattac tcatttgttc tgaaaatata cccagcaaaa aagaatctga tgctactttt 357660 gtgccaacag gttcaaatgt agaattgata ctaattgtca agaagaaaca caatattcaa 357720 gaatattaaa aaaaaaaaca aagaatacag tgaactccca ttccttagga aattattttt 357780 atcactgaaa attaggattt ctaaatgttg ccaataatgg tagttccaca ctgcagaatc 357840 cctcttccat tctatgtgaa attgaaatct gtttcaaaag accatgtagc aaaatatgga 357900 aatacatgtc ccgtggatgg aggaaatagt ctgaaacttg attttgttgg tatagcccat 357960 tattaaccca cttcattcta catgatccta aagggattat aatgacaaat attgaaataa 358020 ttggtctaag gtaagatttt aaaaatattt tctatgcatt attttaatat atgcacctct 358080 gtttcccaac catatggaat attaaattag ctatttggac atttatgaaa ttcaaaagtg 358140 aagttttagg atacgttaaa atcaggaata tactttgcaa tttatcctgc attccacttt 358200 tatttcttta gcttatgagg agttaattcc ttattaatag gggtccttct tcattcccat 358260 tctccttctt gagaataaat ccagaatata attactggtg cataatagtt ccaagaattt 358320 tcagttacag caggtaaaaa gtaggttgct aatagctgcc atataattat attccgttga 358380 cagatgacat tcagtttatg ttccagaaaa tattaagtat acactttcag ttttatatga 358440 aacttttttt tggtatagct atccagaaaa atatggaaag attttgatta atctatgaag 358500 atttgaagaa cctacttctg caacattttc aatttcccaa ggttctattg ctgtaggaag 358560 cagcagacat gaataatatc attctcttct cttgctttgg cttaatgctt aacctgagtg 358620 acctgacaca taccttgatt ctggttcaac cagtaaactt aatataactt ttttaaagtg 358680 ctagcattgt ttgcaacagc tattcccaag tcttagagag aaaactttta tattgtaaca 358740 ggttaattct tttattgcac tatcacccac atgaactcgc tttaatatat cctttggaat 358800 cagctgttta tcttcctgga aaacaagcat acacacacac acaccacaga agacattttg 358860 gcatttgctc ctcaccccaa agtgctcttt cactactttc cctcttccct atcactgtat 358920 tcttactcct catcagcaca tcacatctgc tctggtcagt cttctttaaa ctccccttgt 358980 cctactcata acaagccttg gaaatttgct tgcagcaatt cctagactag acctattgcc 359040 atcctcttct ctatatatca aagccttctc atttctgaga tccaaatcat ctccaggtaa 359100 gtttaatagg ctccccagct tgcactgatc tatcccatcc ttaaactcaa agagcactta 359160 gtctattttt acacaactaa acaatttatt tccatactgc tttgtgtttc ttgctagata 359220 gctagatgat gataatgatg atgatgaaaa agaagaaaga gaagatgata atagatagat 359280 tgatgaagat agatagatag atagatagat gatagataga tagataacct gtgtatatat 359340 gtgtctgtat aatgagttta tttcattttc ttaactatgc cttcagaggt aggatcataa 359400 catcttttta aaatatctct caaaatacct aacactgcta actcatcaat tggtaattgg 359460 gctaaataaa ctgcacattt tatttaatgc atgcagtaca ttctcagcat tcataagaga 359520 aggttatgat gtctgataat acttccttga tgagagggag taacaacctc atgtattcat 359580 tcatgtgaca tttattgagt ttatactaag ttccaggcaa gccaaataag atacataaaa 359640 gttaattctt ctcctccttt tatatactct gcacttgctc tctcgttttt ttactgatga 359700 ggaaagtctg gaaatgatgg ggagacactg tgctggatag aacatcttag ataagaccat 359760 cctgaactga attgtaaaag gttgagactc tcttattcca ttagcttcca agtgggaaga 359820 taagaaaata tcatttgtat tcaaatttcc acccctatca tttaatactg acaatgttct 359880 tgactgtatt gtttgattct tccttgtctt ggattcctaa tttgtaaagt aggcataata 359940 tcttcttcat tgtagacatt cagtaaaagt ttagtgtcat ttccaaggca aaactgcaaa 360000 taattttttt tgttctccag atgtatatgg aatgcctaat ctgaaaagga tgctgtttca 360060 caaactctgg ttacagtggt gacacatccc tgccatctag ttgagtggga aaagatagaa 360120 agaataagag aaaatcaaag tgtgacaaaa tttatactgg taataaatgg ggcaatctgt 360180 gagcagaaag ggggcacgta acccagtctg gaggagccag aagaatcatt gtcgacatta 360240 aaacacgaag gaagccagaa ggatgtcagc tgggtggaga ctcaggtagc aggtgcaagg 360300 cagtcaccaa aagcagcaca gtgattttca agcccagtga ataggggagg caaagtccca 360360 gaggcaactg tgggaagagt agcatgagac agctccgatc tcttaaccat cctccttttt 360420 ccacctcttt ttccttaacc ccctcacttc gtaacttctt gccctatata agctagacca 360480 ttctcccagg ccagttttcc attccaaaat gttcccttca tatcatggat gactatctga 360540 taaactggcc caatgttctc aggtagtata caaaattata aacagagttt gtttaaaaat 360600 aaatcccctc agttcccatc ataataaaaa gccatgtttt ctgaatgcca ccaatttgat 360660 gagagtatct catgtaaaaa gctgcatgaa aaactgagag ttttgttctc actgggatat 360720 atttgcatct tgaatgagaa attaattaac tcaaatgaat tttattgatg gaaacatgca 360780 ggaggaaggt gagggatggc aggagaaagg aaagatatgc tttagattca ggctctctgg 360840 tttacaccct cccaaatttc ccacaagttc accttcctta ggtaccctcc caatcccatt 360900 gctatagtca tttctctttt ttcaccttca gaaggagtta ggggttcagt caaacagcct 360960 tctgctgaag gaggagaatg aatgtacaat tgtgaggagc ttcctgtgtt tactgaagac 361020 tgaatcattt acaatgtagt aatcagtcag gaaaaccaca aaaaaatgca tacaccgcaa 361080 gtgtctattt aaaattgcag tatttcaata aggcttaaat ttaaaaaaaa aacagaattc 361140 ttaaagtaag taacctgaac tccatttttt atagcataat ctaatgcttg ccttcaacta 361200 gagattttct ttcctctcct aatgtcttaa aatagcttca ttaaactctt aagaaatgat 361260 gttcttcttg acaaaatcat gcttcatgga atatcaagtt acatttgcaa taccttcaaa 361320 tgaaatctaa gatgacattg tcatgaagta gaaattaaaa taaattccat ctcttatttt 361380 gaggttcagc ctgcatttat tttccattct aagaaagact aaaaggcagg gattaatgaa 361440 ctaaaaaaag gcattaggag ggattctcca caatgcttct ccaaaggcat cctcgggtag 361500 gtaaaaatat tatttctctt cagcttttga tatctgattt cactctatac ttcagtcata 361560 cagccatctc aacacacaca cacacgcaca cacacacaca cacatgcaca cacacacaca 361620 atttcctaat gtatctcaag ttgaatttat ctgcctctat cttaggagac atcatttatt 361680 gtttcctttt catcttatga gtatgcatat aaatttcatt tctaatctat aaaaatgaaa 361740 taaacaagaa ccaaaatata tatttaggac aaatgtgatt tatgcttaaa ttgtcaaagc 361800 caattgctca ttcagttaag ttttgaattg tactttgggt actgatcatt tgttctcata 361860 aacaaataaa catgcttgct tgaaatctat aagaatatat aaagttcaca agcctttcat 361920 tttgccaaaa atctaaactc tgatatttct ataacaaaaa taaaaccttt catcaataca 361980 caagggtatc ctttagcaaa taaataatta gcattatttt ttaagataaa taatttgtat 362040 tcaacttatc aatgaatata agatatattc aagctattga atgacttttt ttgaaaaaaa 362100 aaaaagactt tcacattctt tttttttttc cattctcatt acagggcctc attctatcag 362160 tcagaggtag aatttttcaa taattgagtc attcccactg acctaaattt agagtgcagt 362220 actgtacctc tctcccctcc ctcgtgattt ctgtgaacag atctgaagct ttaaaataaa 362280 aattgcccgt atgttttatt tggatccgtt ctgcttcctt ctaaaaagca ccaggaaagc 362340 ccagggagtc acaatgatta aggacatgtt ctggagttta acctgctctc taaaacggga 362400 tgcattccag ggcataaaag aaactctgaa gtaggtcaga agctttaact gcctgagggc 362460 ctaccttaca cgggaggcaa gcaggtggtt tgaaattaaa ttagtgccag aaacatcaat 362520 gaatcatgat tctatggctt tatattagac tgaaaggtga ggaaatacag tgtgtcataa 362580 ggccttcaaa acctcattga tttggacttc ctaactttga atttgcatta attcagatga 362640 ggacttggtt tgaaatcatt ttgtgcggtc cctgaagtgg gttgaggtga tgtgaaggag 362700 agaatttgca aaatgaatga gggaaatatc tagcctataa gattatagac aaacaaaata 362760 ctttccagaa taacattaga agaatcacag agtaaatatt gtaattaaaa ttgttcttat 362820 tacacttaca acattttatt ccaaacaagt agattaaatc tatgagatgc tcatcactga 362880 ggtaatacat ggtgccccct gacctcaagc agatcacaaa tacttgctgg aaaatctgct 362940 cgcccacttc cacctgtaac agtctatggt actataatga acaattaact ggggagaggt 363000 ggagtacttg caattggcaa tggaaaatgg acatagcttc ttgcaggaga tacccagatc 363060 attgggagcc ttgagcagtt aatccaggtg tgtgaagacc tttccaaggc ccggtctaat 363120 gggctctact tgtgtctagt ctgacctcta tcttctacca ctgtacctag cccatttcct 363180 caaggatgcc ttccttaacc tgagttaaat tcatccagtc acacactttc acagtgcctt 363240 ccttttatct tctatcacac atatcacaat tgagatgaaa tctttatttg tgtacttatt 363300 tgtgtcatac ccattttgcc ccactagtga ctaagttcca tgaggacagg ggctgtgtct 363360 tttttgtttc tcatagtttt cccagtgtct gctcaataaa agttgggtgg gtgggcaaat 363420 ggatggatgg atggatggat ggatggatgg atggatggat agatgtttgg gcagaaggct 363480 atatagaaaa atgtaggcac gcatttgaag aggtaaggta gagtcagaat tctaccacat 363540 cccctcctaa atcaattatg gcatttggct tttaagaggg gaatagtatt tcatccagta 363600 atatgaaatt actgaaaata aataagtatt agaacaaaat atttttgtag aatttataat 363660 atgtttgctt cttgtgtgta tcagtgttat tccctgtgaa gacagaaatg acaacctgct 363720 tttttttagg gcctgactgc tggaaaataa ataaataaaa cttccctcat ataaagtccc 363780 tccttctcta ttctatctct gaagcctgca ggaaagaccc tgttgacttt ttttctcaag 363840 caggcttgcc taagaactgg aaagagagcc caaaggaaga aggcagctga tgaagctgcc 363900 aggcagcttt gtgctccaga agccctgggt cttggctttg actcttgtgc tccctgcccc 363960 ttggcagttg agctctgagc actggtgatg cattcattca gggccttagt ctcctctggg 364020 gtgagtccat gttagtaagt gaaaagatac catggcagga aaatctgcag aatgtcagga 364080 atgatcataa ggctctaagc tttcaagata ctgcctttaa tcgttactta ctgctaggca 364140 agaattttat acttctcttt cactcttgtt tttcttactg cggttaggaa atttatcttt 364200 aaaaatcagt ttaaataggt ggcctgaatg acaacattta tatgcctagc ctaagccctt 364260 agatgcccta gttcctaatt cctgaggtaa ctaagacata aataaatctg atgcccaagg 364320 ctacaacttc tgctcctgac taatgcattt ttaattgtta ttatataaaa gcttgtattg 364380 caaatatgag acttaataat gtgcataacc actttttaac atctgagaag ctgtgtttcc 364440 actggaggta acaatagaat cttagttttt gaagcttcaa atttgcaatt attctctgga 364500 aaggccttca ttcttcagtt cattagggaa tgacacatga tgttttctgc cattattatt 364560 tactaaagat agtataggat tgacctctgt tttatcaatt atctcaagat tagttgtatt 364620 gaaagatgtt ttaaaatata tttagtaaag tatactaatg aacctataat attaaggata 364680 cagagcaaat gacatatagc ttagtaaaat ggaagtaatt taaaatgaac tggtaagaaa 364740 atttcattag tttcagattc ataaccttta ttttaaatat gttacattaa aatataatat 364800 ctgctgtaaa aattatctag tttcagcatc tgtcttcata agaagttaaa tgatagtttc 364860 aggataatga gttttgctga attactgaat gtattaagat gctctcgagg tattcttatc 364920 caatagtaat gccaggcaaa tattaatatt ttgatacagc ctctggtata atgaatatgt 364980 cttggaatat taacactaga agtttgctct ataaaagttt gctctatata aagtttcagt 365040 gtaattttca ccagaaagtt taagggcatt atttcagcaa gtttcaccaa gaaagctgag 365100 aactggtaaa atgaatttca ttaatgggcg ccagactcct ttaatgagat ggcaggcttt 365160 gggaggcttc atatgagttc taaatgttcc ggacaaggct tgcaatttgc tttgctgaag 365220 gcatagagtg cccccaacaa aaggggcttc tccagttgca gttttctggg ttaatgtatt 365280 ccaggttgaa ttatctcacc cattgattgc tgccctggga atttcagtgt tcatacaaac 365340 taacaaacgt ccaccagata agcaccagca atgcccagct ggctctttgt cccccatggg 365400 aaattttctc agttagagct gggtaattgt ttagtgcagc tgctgcagtt tcaagggtgc 365460 cagctcatct gagccaactg tatgcacaca gcccatgact catgaggctg agaaagtaca 365520 cactgctggt gggtgggtgg gggccttcaa ggactccatg ttaaatttgc cctcttcttt 365580 gtcaactatt tgggggataa tacatagtga aaggcagtta tttaaggggt ataaatatcc 365640 tatatcgtga aaatcagcta taggtaggca taataacctc atctttatta aaaagctttc 365700 actgtatgta tctgaacagt cacttggctg tactgtatgt gttataataa cataacattg 365760 taagatgtgt ggtttcttac atacacccaa atatggaact ggcataatat ccagagcaag 365820 ggacaatttg ggtggagacg gggaaggcaa gcactgttct ctggcctcat gccacgctat 365880 ttggcatagg gttcaatatc agatcttcca aaattattct agaaataccc aaaatatatt 365940 ttgtgagaca actgattatt attgtgaggc aatttgaatt tattagggct ttactgtcaa 366000 ttagacacgg taatgtcctc ctggaaaaat tcttttaagt agtattctgc acataaatgg 366060 catctttaaa cagtgtcatt cgccacatgt ataccacatg tctccagggg cttgtagtat 366120 atataataat aaagtaagag ttcttgataa attagtgatc tattgttcag tgacaaatta 366180 acctaaatct tagtgtctga agacaacaag cctttgttac cccacagttt ttatggatcg 366240 agaattgaag agaagcttag ctaggtgttc tcactccagg tcttccacaa ggctggaaga 366300 atgtgagctg actcttctga gctcacttac gtgagccttc cagcaaggct gatttcctcc 366360 agagcaatca tggcagctgg tttcctccag agaaacagcc taagagagag tgtgagagtg 366420 cacactgtca gttatggctg cagttgtctc aaagatcaat aagggatgat ctgtttccaa 366480 gcttgcttac taggctgttg gctgcctcag atgatcctct tctgagctta cttatgtgag 366540 ccttccagca aggctggttt cctccagagc aaccatggca gctggtttcc tccagagcaa 366600 cagcctaaga gagagtatga gagtgcacac agacagaagc cacagccttt ttacaactta 366660 acatagtaat gacatctttt cacctctgct atattgtatc catatgaagc aagtcagtaa 366720 gtccagccta cactcaagag gaagggatta cataaagaca tgaataccag gaggcagaaa 366780 tcttaattca aggcatcagc ctttctctct ggaattataa tagctacctc taattagttt 366840 cagaacctcc aattttgatc tactccagtg aaactatttt tgctatggca aagtggtctt 366900 taaaaactgc taatctgatc atgtcattta acaactggta actgtcctca agagaatgtc 366960 taatcttctt attatgaccc tttatataca gtgcataaag acagtattaa atggtattta 367020 aagtcttagg ctctaaagcc aagttgcctg gcttctaatc ctggttctgc catgtatcac 367080 ttttatgccc ctgggaaagt ttgctaacct catgggactt taatttcttc attgaaacct 367140 gaaatggtaa taagagctac tttataggat tattgtgaaa attcaatgag ataattctta 367200 tgcagctctt ggcacagtgt ctaggacata gaaagacctt aagaagggta ggttgttatt 367260 ataattcccc attttatctg agccatttca tgccatattg tgcaaccaca gcaaactaca 367320 gtagagtcaa ttttgacctc ttacaaagct gtctttatct gaagagcttt catttattca 367380 taaaaactca attcagagag ttaagttttc ctacagaaag actttataca cacacaaatg 367440 cacatactta agcatacaat tttggacaaa gtggttttct ctgtactccc tcagctccta 367500 tgtataactc tatcatggtg ttcatcacac tgtatcgcca ttgttatttc tctatggtcc 367560 ctattagaat atgacctctt ctaaggagtc ttttatttct gtatccacag agcctagccc 367620 agtgcctggc atataataaa tatgtcctta atgaatgtgg gcagaatggt ctaataaata 367680 aatgatttgg gagttttttg atgtagtctc cttcttcatt tcttcatcct acttctgaca 367740 cccacttact cattccctca cctcaagtcc tgattgcata aggatatttc aactgttgct 367800 ttgaagagaa agctgcccaa acaagttgtt aagatcaaag aacatgtttc tcctcatatg 367860 cagttctaaa gacacaaatt aaattaaggt caatatttct ttccctgact ttctgttatt 367920 tgggcttttg aaatttacaa ctttgtaata attgcttcac tcccaagcca aactcctcag 367980 tcaggcattt attttttttc tctttttttg ttttatgatt ctagtatttt ttatttttta 368040 tttttattta tttttaaatt atactttaag ttctagggta catgtgcaca acgtgccggt 368100 ttgttacata tgtatacgtg tgccatgttg gtgtgctgca cccattaact catcatttac 368160 attaggtata tctcctaatg ctatccctcc cctctccccc taccccacaa caggccccgg 368220 tgtgtggtgt tccccttcct gtgtccaagt gttctcattg ttcaattccc acctatgagt 368280 gaggacatat ggtgtttggt tttttgtcct tgcgatactt tgctgagaat gatggtttcc 368340 agcttcatcc atgtccctac aaaggacatg aaaatcatcc atttttatgg tgtttatatg 368400 ccacattttt cttaatccag tctatcactg atggacattt gggtcggttc caagtttttg 368460 ctattgtgaa tagtgccaca ataaacatac atgtgcatgt gtctttatag cagcatgatt 368520 tataatcctt tgggtgtata cccagtaatg ggatggctgg gtcaaatggt atttctagtt 368580 ctagatccct gaggaatcac cacaccgact gccacaatgg ttgaactagt ttacagtccc 368640 accaacagtg taaaagtgtt cctatttctc cacatcctct ccagcacctg tcgtttcctg 368700 actttttaat gattgccatt ctaagtggtg tgagatggta tctcattgtg gttttgattt 368760 gcatttctct gatggccagt gatgatgagc attttttcat gtgtctgctg gctgcataaa 368820 tgtcttcttt tgtgaagtgt ctgttcatat cctttaccca cttgttgatg gggttgtttg 368880 tttttttctt gtaaatttgt ttgagttctt tgtaaattct gggtattagc cctttgtcag 368940 atgagtagat tgcaaaaatt ttctcccatt ctgtaggttg cctgttcact ctcatggtag 369000 tttcttttgc tgtgcagaag ctctttagtt taattagatc ccatttgtca attttggctt 369060 ttgttgccat tgcttttggt gttttagaca tgaagtcctt gcccatgcgt atgtcctgaa 369120 tagtattgcc taggttttct tctagggttt ttatggtttt aggtctaaca tttaagtctt 369180 taatccatct tgaattaatt tttgtataag gtgtaaggaa gggatccagt ttcagctttc 369240 tacatatggc tagccagttt tcccagcacc atttattaaa tagggaatcc tttctccatt 369300 tcttgttttt gtcaggtttg tcaaagatca gatggttgta gatgtgtggt attatttctg 369360 agggctctgt tctgttccat tggtctatat ctctgttttg gtaagagtac catgctgttt 369420 tggttactgt agccttgtag tttagtttga agtcaggtag catgatgcct ccagttttgt 369480 tcttttggct taggattgac ttggcagtgc aggctctttt ttggttccat atgaacttta 369540 aagtagtttt ttccaattct gtgaagaaag tcattggtag cttaataggg atggcattga 369600 atctataaat taccttgggc agtatggcca ttttcatgat attattcttc ctatccatga 369660 gcatgtaatg ttcttccatt tgtttgtgtc ctcttttatt tcattgaaca gtggtttgta 369720 tttctccttg aagaggtcct tcacatccct tgtaaggtcg taaaactcca cagaatctgc 369780 tccacacaga cctcttcacc cacaccatct ccaaggctct ttctcattga ctgctctcaa 369840 acacgtgtat acacacacac aagcacaagc atacatacac acaaatgcac acatatagaa 369900 acatgcaaat atatacacag gagaccaagt gcatcggatt cattttagat gcttgttaaa 369960 attcagattc ctgggcttca cctagtctca gagggcaaag agcaggaaat ctaccttttt 370020 tttttttttt ttaatttatt gatcattctt gggtgtttct cgcagagggg gatttggcag 370080 ggtcatagga caatagtgaa gggaaggtca gcagataaac aagtgaacaa aggtctctgg 370140 ttttcctagg cagaggaccc tgcggccctc cgcagtgttt gtgtccctgg gtacttgaga 370200 ttagggagtg gtgatgactc ttaacaagca tgctgccttc aagcatctgt ttaacaaagc 370260 acatcttgca ccgcccttaa tccatttaac cctgagtgga cacagcacat gtttcagagg 370320 gcacagggtt gggggtaagg tcagagatca acaggatccc aaggcagaag aatttttctt 370380 agtacagaac aaagtgaaaa gtctcccatg tctacttctt tctacacaga cacagcaacc 370440 acccaatttc tcaatctttt ccccaccttt ccccctcctc tattccacaa aaccaccatt 370500 gtcatcatgg cctgttctca atgagccgtt gggtacacct cccagacggg gtggtggccg 370560 agcagagaag ctcctcactt cccagtaggg gcggctgggc agaggcgccc ctcacctccc 370620 ggacggggcg gctggccggg cggggggctg acccccccac ctccctcccg gatggggcgg 370680 ccggcctggc gggggctgac ccccacctcc ctcccggacg gggtggctgc cgggcggaga 370740 cgctcctcac ttcctagacg gggtggctgc ccggcagagg ggctcctcac ttctcagaca 370800 gggcggctgc cgggcggagg ggctcctcac ttctcagacg gggcggctgc cgggcgtagg 370860 gtctcctcac ttctcagacg gggcggccgg gcagagacgc tcctcacctc ccagacaggg 370920 tcgcggccgg gcagaggcgc tcctcacatc ccagacaggg cactagggca gaggcgctcc 370980 ccacatctca gacgatgggc gggcgggcag agacgctcct cacttcctag atgggatggc 371040 ggccgggcag agaggctcct cactttccag actgggcagc caggcagagg ggctcctcac 371100 atcccagacg atgggcggcc aggcagagac actcctcact tcccaaacgg ggtggcggcc 371160 gggtagaggc tgcaatctcg gcactttggg aggccaaggc aggcggctgg gagatggagg 371220 ttgtagcgag ccgagatcac gccactgcac tccagcctgg gcaccattga gcactgagtg 371280 aacgagactc cgtctgcaat cccggcacct cgggaggccg aggctggcgg atcactcgcg 371340 gtcaggagct ggagaccagc ccggccaaga cagcgaaacc ccgtctccac caataaaata 371400 tgaaaaccag tcaggcgtgg cggcgcgcgc ctgcaatcgc aggcactcgg taggctgagg 371460 caggagaatc aggcagggag tttgcagtga gccgagatgg cggcagcaca gtccagcttc 371520 agctcggcat cagagggaga ccatggaaag agaaggagag ggagaccgtg gggagaggga 371580 gagggagagg gggaggggga gggagagggc aaatctacct tttaataagc tttctgggta 371640 gtccttatgc ataaaaaagg ctcgaggacc acagctctca ccccaccggg ctttgatagt 371700 ggaacgtact cttctaaaaa gcatatcatt tccaactgaa aacaaacaaa aaccaaaagc 371760 acatatcctt taagattcac tcaactagta ccgttgtcaa agatccctag atggcccaca 371820 gtagtcaatt cctcctgctt cctttgtcac atggtaaata ttattggttt gcatacaaac 371880 tactcaggtc agcccaagag tatcttgagt tcaaggacat ctctggcggt acttctggta 371940 cagggtcaaa agcatagttg ttcaattggt gtttactgaa gtgttaccta tggtactaaa 372000 atatgatttt gctctcaaat gtgttggttt atatgaattg acaaggcttt actttttatt 372060 atagcataaa atttcataac agtatttagc tattacatac caccttaact tttcaaatgt 372120 actataacaa agaatgaagg caaagcacag ttgctcacac ctataatccc aaaactttgg 372180 gagactaaag caggagaatt gtttgagacc agcctgtgca acatagcaag attcctgctt 372240 ctacaaaata aaaattaaaa aattaggcag atgtggtggt atgcacctgt agtcctagct 372300 acttgggaag ctgaggaggg agggtcacct gggcctggaa gttcgaggtt acagtgaact 372360 atgattatgc cactgcacgt cagcctggtc aacagagcaa gctcctttct ttaaaaaaaa 372420 aaaaagggaa agaggctggg tgcagtggct cacgcctgta atcccagcac tttgggaggc 372480 ctaggcgggc ggatcatgag gtcagtagat cgagaccatc ctgggaggtc aggagattga 372540 ggccatcctg gctaacacaa tgaaattcta tctctactaa aaatacaaaa aattagtcag 372600 gcatggtggc acgtacctgt agtcccagct atttggaagg ctgaggcagg agaatcgctt 372660 gagcctggga ggcggaggtt gcagtgagct gagatcacac cactgcactc catcctgggc 372720 aacagactga gactccgtct gaaaaaaaaa aaaaaaaaaa aaaaaaagga aaagaataaa 372780 taccttgccc aagatataga aatagtaaaa gaaaattaaa ttcttctgcc aagatatttt 372840 gttgataacc ttgcataatt tgaggtaaca acctggaaat tagatcataa gcaaatttca 372900 tttgtttttt cttgataact ttatattctt tagtatgaag acataggtca gattgtattg 372960 agatttttat ttagatcttg gtatctcaat tattttaatg ttttaacaat gctgcagaac 373020 ttttcttctc tgattggaaa tttgagagtg tcagatgccc agtaatcaga ctcctccatg 373080 ttaacataaa caggtatcaa acacataaaa gtggagccac tgctgagccc accagtgcca 373140 ggatgactac tcccagatgg agaggacaaa gagaagtggg cattaaaaaa acctgaacac 373200 tctgacagag tcagttctgt ggtctaaatg tttgtatctc ttctacattc ctatgatgaa 373260 ccctacttcc cagtgtgatg ttattaaaag atacagcctg tgggaggtaa ttagatcatg 373320 agggtaagag cctttatgaa caagattaat gccttgcccc ttccaccacc tgaggatgca 373380 acaagaaggt gccatctgtg aatcagaaat caggccctca ccagatacag aatctgctgt 373440 tgccttgatc ttggacttct cagattccac aactgtgaga aataaattcc catggtttat 373500 aagcaaccca gtctagggca ttttgttata gcagcccaaa aggactaagc ttccggcaca 373560 taaatgtaag atttcaccag ctgattgagc attgtcttag tctgtttctg ttactataaa 373620 ggaatgtctg agcctagtta atttataaag tataaaggtt tacctgcttc acagtttaca 373680 ggctgtgcaa gaagcatggt gccagcacct gcttctaaag ggtgttcagg ctgcttccac 373740 tcatggtgga aggaaaaaga gagcccggtt tgtacaggca agagaggagg caagagagag 373800 aggagggaat tgccagcctc ttgaacaacc agccctcaga gaactaataa agcgataact 373860 cactcatttc tgtgaggccg tgcaaggccg ttcatgaggg atctactcca tgacccaaac 373920 acctcctatt aggcttcagc tccaatgttg gggatcaaat ttaaacaaga aatttggagg 373980 atcatatatc caaactatag caagcatggt gaattacctt gagaactaag ttgacacatt 374040 gatttcataa tcttaggtga aagaatcact tcaccttctc agtgacaaga taacttctgc 374100 tgactgaact ctttcctaaa gacaggcaat tcacacagct ttctaagcct cagacagtgt 374160 gaaatccttc aggctgtatg gtttttcttt taatatcttg tgaattccca gaacaaagcc 374220 tcccactgtc ataggaaaga actaaaatgc atcctgaagt caaacagaat tatttggaaa 374280 tgacatgctg gttatagcaa tccactcatt ccctcaagaa cagatataag caaaggttga 374340 ctacattgat gcctctcttc atttttaagt gagtctttct cttttaatca tttcctattc 374400 tattttacat ttaatacatt tgaatcacct ctcctcattt cacatcttat ttataaagtt 374460 agtgtccaat taaattgttc ttaaatttac tgacaatcag atacttttga gtattttagc 374520 tgagtggcag tcacttaaag cccattacct gtcctcaaat gaaaaaagca accaaacaag 374580 ttaccagtga agtaacacta cacaaaatgg cagcctcaga tggcacttgg tttactcaag 374640 atatcatcat tctgcatcta tggaaaacac aacaaatcac agaaatgtgt ttctggtacc 374700 tgatatggtt tggttgtgtt cccacccaaa tctcatcttg aattgttgtt gccataatcc 374760 ccacatggtt accctcatgc tgttctcatg atagtgggtg agttctcatg aaatctgatg 374820 gttttataag gggcttttcc ccctttgatt ggcacttctc cgtcctgccg ccatgtgtag 374880 aaggacgtgt ttacttcccc ttactacttg attgtaagtt ttctgaggct tccctagccg 374940 tatagaactg tgagtgaatt aaacctcttc tttttataaa ttacccagtc ttgggcggtt 375000 ctttatagca gcatgagaat gaactaatac agtacctttt aaattttctt tcataataca 375060 atattgtcag gcaagggttc cctaacacat ttaatatata gtgtctctct tgtgccattt 375120 ttagactcta gctagcatag cataccagca taaatatgtg tattaagttt atatacttat 375180 ttgcaacaca gctatcaatc ttacaccctg acactgttta tagtggcaag gaagtagatg 375240 cggtcaatta aataaagaga gataaggcag tacacagatg agatgttaag tctgattcca 375300 tgcaatactg ggtaaattct gaatatcttc acaggttgag tttagttcaa aacaacatgc 375360 tataaaatgg aatattgatg atggagttta aaagtaatta atggtgggca gtctatcatc 375420 tgggaaaata gatgcctcct ttggatccat agctgcttaa aaattcatag agaaaaaata 375480 aaaatgggat aaaggagtgc atgaccccac aacaggatgc acctttacat gatacttaat 375540 ggattttttg taaatgtaca atattgatat acccagttaa ctatagtcag attctgctta 375600 taacctcaac gaatacaatg cgcaccatta ctcagcatga ctcactgaat tgtccctata 375660 caaaacaata tccttgcaac tgaaatgatt gatgtgaggc agctttcact ctagcacagt 375720 taaattaaac acaaaagata ctcaggtaga aatttttgta tgcagaaacc tgccattaag 375780 tcctgtactg ccacggcaat tgcctgtata ataagtgtat agggcacatg aatactttta 375840 aaaatacatt tctatattgg aaatctgaat aaaatttaaa ctattttaat aggaaatttt 375900 ctttgatcat agagcttgca tttaatatca ccaacgcaat gattactctt gactagtgga 375960 ataacttatg gcataaatag tgcagtaaca attggaatct cagagtatat gaaggctgaa 376020 agggatatta gagatcgctt agctcaaccc acttattttc tacttgagat aatttgtttc 376080 acagttcttc catatgctgg tctcagagca gtgcttcctg gtgacacaga taatactgtc 376140 cacaacaaaa tgatagagat gaaacagtat aataaggtct tggtaaagct gaatttgctt 376200 atttaaaatt attgcctttt attcctagac tttccccttt ctgatgtttt atctccatat 376260 tcttttatga aatgatcatg gtagagaaaa atagttgctt ttcctaacat tcataattgg 376320 ttaagtaaaa agttggcaac cctataatat gccttatttc ttttttaatt ttacaaaact 376380 ttgaactcca agggttgggg aaccaccact ttagacgcca acatagaaca gagtcccttg 376440 atgtatctgt atatgagagg ggtaaacaca tttatcagta agggaaaatt agtaagaagg 376500 attatttatg aaatgagtta tgttaaaaga cattgcttct gtttaccacg taaaatttga 376560 tgaactgtca caaagggagt aatacctgcc ttttgttatt tatatgtgtc tgacaagaga 376620 gtaaatgcag cagttttagc tgtatttaaa caaaactggc atattttatc taacagtaag 376680 atgtcaaatg ctgtaagaat aaggaaatca aggagtccgg gacatggata tagttatatt 376740 attacacaat tattaggcta gaggttagaa agaaagtgat agttgccatc aggaggcata 376800 aactagcttg atttctattt gttctttgtc acttgcataa tactttttgt ttcagttagg 376860 tattatgaga ttcatgcctc ccccctagga gacatggata gacataaaaa gtccttgtag 376920 tttttatcta aaaaatgtca aagctaaaaa aatttctcat gagatatata gtataatatc 376980 agccaaaatg gaattcagga ccatttagaa tcaagagaaa ttgcctccta ggaagttacc 377040 ctgtgaaatg atgcacaaaa ataggaagct aatgaatctc tggtacaaaa ttatgcttct 377100 acatcaagtc tcttaaataa gcaagaatgc catatttatt tctttgcatt tatttcagat 377160 gattcatgta cccattggtt taaaattact tatgagatta gctactaaaa gactttggtt 377220 gatagttggt taacaaaaga aggaagttat tatcattagt acttctggcc aacatttagg 377280 gatagctctt tcttgactat gatagaatca gcttcagact ttaagattca taatggcttt 377340 cagtagaata catgatttgt tttctccctt ggataaacat atcataatta aaacctaata 377400 tttttctaat tgtttctgtg caggtttatt tggtaacttt ttaaaaaggg gaatgctttt 377460 ttttttttta cttttttgtt atagttgttt ttttttatta tttgaacatg gaagagagat 377520 tcttagtaat caatatgcct acaatattag ggagtactgt atttctgagt cctagaaaga 377580 tatttttcaa aggacctttt aaatttaaaa caacaaaaat taatttttca aataaccaac 377640 ttcatcctcc ttacatgttt ttgaccatgt gggtcacatt ttagccatct ggtgaaaaaa 377700 ataatatatt gactttttac tatatgggca gcaatgcatg tggggtcgtt taaggtacag 377760 aaaatatggc aaacatagtt aaggccatca gggagtttag aatctagtaa ccaactctac 377820 aacctaattt ataattcctc ttttcataga gatgaaacaa taaagcagaa gtctgacttc 377880 tgttaaaact tttttattgt ggaaggagaa aaaaagggaa gaaagggagg gaaggaagga 377940 ggaaaaggag agagggaagg agaaaaaaaa taaatgattt aatacctgac tgtgtggaag 378000 acaccttgtt ttacttctta tggttctgtg gaattggcct atagctattc tggcactttc 378060 tattccttgc acttctgagt ccctaatgaa gcttgtcaga tctccaaaaa gaacaagtcc 378120 ataaggcaaa tgacagcctt ccaagaacct gttactaaag tgaatgactt gagtagattc 378180 ctgtggttag agtcgggttt tacagactct taattgattt aaccatcaga cctggcccga 378240 ccaagtaaga ctcatcaact actaatatga tggagatatc acatttgcta aggctactta 378300 gtaactgaat ttactccgtc cctgatagga aaatttagca ggaatgagaa attagtattc 378360 cttttgttta agtttaattt tattttaaag tcacaaataa taattatgta tatttatggg 378420 atataatgtg atgttttgaa atacgtaaac attgtggaat gaccaaatca ggctaattaa 378480 cacatccatc acctagtcaa gctattaaaa agcaaaacac aggcctgaga atttgcagac 378540 catacacctt gcaaatacac agaaaatccc tgtcaataat gaggaatcat ctaactgtgc 378600 ttcaagcaag ttgccatcct tgactttatt gtgactattg tgactttaaa tacattccct 378660 actagtgcca cctgtattgc tttatatttt gttttctatt tcctaatctt actcttttga 378720 ctctctctct ctctctctct ctcttgctct ctctctctct tgctctcact ctcctgatga 378780 ttctagatgt gtttgtgatc atacacaaac attcagagat ccatagaaat ccaagcctta 378840 tgttagggat ttttaacttc ttgtaggtga tagatgactg aaaattcgat aaaggacata 378900 aacacatatt cctagggaaa taaacagcaa tgaaacactc taaattgctt taaataactt 378960 ctggagttca agcccaccag tacatcccag gacaatacac catggtcgag tagtatgtgc 379020 ttgctcacat acatacacac acatttattt ttcctcatta tcctggaatt cccatgggta 379080 gtgtttctga ttttttttcc ttaacgtaca ttaatccttg acctgtaaat ggtgcaaaca 379140 tagtaagatc atactaattc gttgcaattg tttaaacaat gtgagttaag aaaaataaaa 379200 taattgtgta atctcagaga tctcctatat gaatcttatt ttgccacgta catcatttct 379260 acaggacccc tggaaagtat actcaaattt taaaactgac agagactcca taaatactga 379320 ctttatttta aagaaatacc atttcatcac ttgcagggaa atagagaaag tcatgcaatc 379380 tctgtcctcc aatcacccat cagatgttcc attttcttta tgacaggtat tccaaccaga 379440 ccaactaaat gttccctagt tccaggattg ttgcttttat gaggacatat gctatcactt 379500 gcttaaatgg ggtcctttca aagtgtttga gggcttttac aaaacagttg gtttcctaaa 379560 ataccacttt gtacgtggcc caaaaaccaa tagatataac tgagatgtac acaaacaatg 379620 aaacattttt atcttactag caaacacaca tggccaactg gcctaaccat ctgtcttttg 379680 cattatctat cattgcataa ttgacttgct ccaaggtcac accagagagc tgggttcatt 379740 caataactat aattagcatt gaatgttatt tgtaatttaa ttttgagcta ttctggttaa 379800 atatccctaa aaatgtatta ttatgatagt aatcatcact tattgggtat ttatggtaag 379860 atagggacta tatgtggaac tatatacatt tgttatctta catagttcac agttgcctat 379920 gaattgtata ttgttgtcct cattttgcta gtaagaaaat tgacactcag ggagatttaa 379980 aaatggccaa ggcagagctg ggatatgtaa taaggcccag agcctgtaat atatcccaga 380040 gcctggtgtc ttcagtaata tttgacctat tatgaatttc taatttttgt acattgtctt 380100 tgtttttatt ttgttgatgc ccatccatgg ctatctagca ttcctgtttt gtccttcctg 380160 tgttcttcac atttgtgtcc atccaaacaa gctgcattta ggctctagaa aaaaaggtag 380220 ttctacataa ttctctattc tccatttgcc acaagtgatg aggactttat taaaagcatt 380280 ttgaaaacat ccacacatac cttttaaaat cttttctttt tctcctggaa ataatatgta 380340 tattaggaaa acagaggctt tatccccaca aataaatgag ttacatactg gtattctgtt 380400 gtataaggac acaggcccta tagaaccaaa ccaccttgga acgttagcta gcctgtcttc 380460 acatctgtaa agtgaaagaa acaatagcac tgcattattt tcttagggct tccataacaa 380520 actaccatga actaggtggc ttaaaacaag atatttcatc tctagcagtt ctagaggata 380580 aaaattcaag gtcaaggtgt cagcagagcc atacggtctc tctgaaggtt ctaggggaga 380640 atgtgtttta tgatggtctc tgagcttctg atgttgttag aaatcttggt gttctttggc 380700 ttgtggacac atcactccaa ttcctgcctc cagcatcaca aagcattctt cctgggtttc 380760 tgtctctgta tttcttctct tctaaaagac aaggcattga tgaactaagc ggaattctaa 380820 tttcatcctc catattaaaa agtcatcatc cttcttattt ttttaaagca aagactaaag 380880 taagtgtcat ccatcctcaa tattttttta aaagcaagaa ctaaagtaag ctgacatagg 380940 gcaccatacg gcagctcagc atcttcctag acatctgtgg tggctgcagc agagtgagtt 381000 tggtcttctt ctctcgaagg aaggaggtgt tggagaaagc atgtcattcc ccacagaagc 381060 attcctccca tttccctttg gtttggtggc aatgattcta aggacaccca cctaggccaa 381120 aggagcctgg ctgagcaaag tgagccttag catatctgtt tctttgcttt tttttttttt 381180 ttttttttga gatggagtct cactctgtca cctaggctgg agtgctgtgg caccatctta 381240 gctcactgta acctccacct cccgggttca agcaattctc ctgccccagc cttccaagta 381300 gctgggacta caggcatgcg ccaccacgcc cagctaattt ttgtattttt agtagagatg 381360 gggtttcacc atgttggcca ggatggtctc aatctcttga cctcgtcatc tgcccacctc 381420 agcctcccaa agtggtaggg ttacaggagt gagccactgc gcccggcctc tttgcatttc 381480 tttaccgcta ttcaccccac ccttccttgc aaaggccacc aaaccaatgg gtgagctggt 381540 tcacatgatt gtgcagaata tggatgtggc tttattggta ttttatacat taataatgct 381600 gttcattgtt aacatcagtt ctcaatttgg tgacccagct ttcctacatt tggaggttcc 381660 actatcccat tacactgaaa gacctaaggc cttggaagct tctgacttca tgaggtagaa 381720 ggaagaaggc agagcaagaa aagatccacc tgcttgtcat aaactttggc caagatgtgc 381780 tactaatcag acccatggcc atacctgatt gcaaatgggg ctgggaactg tagttctcga 381840 caaggcagac acattctagc aataactaca ctttaggaat ggagaacaac aaattttggt 381900 ccacaacagc tgtctctatc ataatctttt ctcttgtgaa tttcctatac ttttatttgc 381960 ataggctctt tctctttaag ctacaaacat gttcaggaat ttgagatgct tactatatac 382020 attacatgta tataccaggt actgtgctaa gccctaggaa tactggttat gccttttttc 382080 tgcttcccac attttagtta tttcttcatg tatactatct cttcttgtac tcttttggaa 382140 aattaatcca ctttccagat cttcagccgt tgcttctgca agtttaaaat ctctagctcc 382200 aacaacatga gagctctatc ccagacctcc tttatattat tattattatt attattatta 382260 ttattattat tattattatt attttgaaac agaatctcac ttgttgccca gactggaatg 382320 cagtggtgca atcttggctc actgcagcct caacctcctt gggctcaagc aatcctccca 382380 gctcagactc ccaagtacct gagaccacag gcacatgcca tcacgcccaa ctaattgttt 382440 tgtatttttt gtagaaacaa agtctcacta tgttgcccag gctcagacct tctaactgcc 382500 tgccgaagac gtcctcctgt tggcatctat gcctctacct cacatcgtcc cagccaaaca 382560 tctaattccc tctcccattt ctcacgtggt tcctctgtca tctgtgcttt tcagaaacat 382620 ttgtaaaact cttactcatg agctagtatg ctaagtgttc cttctcttaa attttactta 382680 ttttctaaat gaaagcaact ttaagacaaa gataaagaaa atggagggaa gaatccatat 382740 gtagtttcca agagacaggt aagaggggag gggaggcaag gaaacaagca ttagactaga 382800 gaccatctgg tatcagctac atggtggggc cagaagtccc tcaaatccat atggcatagg 382860 agctgcgaga caaaaccaag aggcattatg ttgctggtgg gtggcttgga gttaagttta 382920 tggctctgga agaaactata ttttttaata tgcatatatt tgaagtaatt tgtaaatatt 382980 ataattgttt aagatattca acctatttct cttacattct gagactcata catattttat 383040 gaagcagata tttttcatat tagcatatat agctaatata caaaacaaaa tgctaaacac 383100 ttagctgaac ctgaatctaa atgactgcaa ttatacaatc atccctactc cacccaacac 383160 acacacacac acacacacac acacacgcac atagccaaat atctatttta atctaagcct 383220 tgcaaaatca ttttaaatac agaacactga agtgattcta ctacctaatt ttaatatttt 383280 attcaattaa aaaatgactt cctatgtgac atctttgatt tattgtgtga tgcttttcca 383340 tcttataatt tgaataggta atcatcaatg agattgctgg tttcagtgat aattactcag 383400 gtttggctgt ttttcacaaa tcatatgctg aaaagcctgg ggagtttaag tccttcccga 383460 tgctatataa tctatctgat tcattttgtt actgcgtgct ctctgtgata gataaaaata 383520 cagctagcct attagttaag tgcaagtccc gagtaaagga taaataactg atgagcagct 383580 tcaaccaaca cctcatcatg gcgtttaaca gctgccaaaa gtactgtata atcttttgga 383640 aagcttaatc gttctctatt gcactttttg aaagtgaaga gtagttacta atcctggtgt 383700 tcgcacaaaa ttttcacagt agatcttcat tgaataaata gttctgtttc atataaaggt 383760 tttggtttta tataacactt aactgttaga ggttaaacaa atagcagtgt actagcatga 383820 agaaaaattg tatttggtaa agaaaactac attttaggct gtactaaact gtatgcttaa 383880 ttagtggttt gagaaaagag aaaatgtaaa tctttctgga ggccatggag tttccctttt 383940 tttattcctt atttttttct ctctctctta aaagaaaatc ctcgtaatag ttcaattaat 384000 catgttttat cttcctgaag tatgttattt ctcaaatgtg tgggagaagt tggctttctt 384060 aaggaaatgt aagactgtgt agcagctttt ttccttttta gtcattggct tcttagaatc 384120 ctattcatgt tgttaaaaca tttactttgt tagtgcttca ttttcagaaa ggatggctcc 384180 aaagcactgt cttgattaat tttaacttat ttgtgacttt caaagagata ggagtagacc 384240 ttataaaaat acatttgcat ttaggtcatt aaaaattaaa attgaccaat tcaaacaaat 384300 taaagggaaa caggaataat aattctgtaa ttctaaactc agttttctgc aagaagaaaa 384360 aaaggagaca attaactaaa taacctattg tcttattaaa aaaggaaaga gagagagagt 384420 atggaggaat atttaacaag caaatggaag caaaaaaaag caggggtttg aaatcctagt 384480 ctctgataaa acaaacttta aaccaacaaa gatcagaaaa gacaaagaag ggcattacat 384540 aatggtaaag agactgatgt aacaagaaga cctaactatc ctaaatatat atgcacccag 384600 taaaggagca cccagattca taaaacaagt tcttagagac ctacaaagag acttagactc 384660 cctcgtgata atagtgggag actttaacac cccactctca atattagaca gatcgagaca 384720 caaaattaac aaggatattc aagacttgaa ctcagctgtg gatcaagtgg acgtaataga 384780 tgtctacaga actctccacc ccaaatcagt agaatataca ttcttctcag tgccacatga 384840 cacttattct aaaatcgacc acataattgc aagtaaaaca ctcctcagca aatgcaaaag 384900 aatggaaatt atataaggaa tgtataaatt ataatttgta taatgtataa attataattt 384960 ccattatgta ttatggaaat tataacatta taaaatataa ccacagtcca atcaaattag 385020 aactcaggat taagaaatta ctcaaaacct cacaactaca tggaaattga acaacctgct 385080 cctgaatgac tgctgagtag agaaagaaat taaggcagaa atcaagaagt tctttgaaac 385140 caatgagaac aaagagacaa cataccagaa tctctgggac acagttaaaa cagtgttaag 385200 agggaaattt atagcactaa ttgcccacat cagaaagctg ggaagatctc aaatcaacac 385260 cctaacatca caattaaaag aactagagaa gcaagagcaa acaaattcaa aagctagcag 385320 aagacaagaa ataactaaga taagaacaga actgaaggag atcgagacac gaaaaaccct 385380 tcaaaaaatc aatgaattca ggagccggct ttttgaaagg attaacaaaa tagatagacc 385440 actagctaga ctaataaaga agaaaagaga agaatcaaat agacacaata aaaaaatgat 385500 aaaggggatg tcaccactga ccctacagaa atacaaacca ccatcagaga ataatataaa 385560 cacctctatg caaataaact agaaaatcta gaagaaatgg ataaattcct ggacacatac 385620 accatcccaa gactcaacca gtaagaaatc aaatccctga ataaactgat aacaagttct 385680 gaaattgagg cagtaattaa tagcctacta accaaaaaaa gcccaggacc agacggattt 385740 acagctgaat tctaccagag gtacaaagag gagctggtac tattccttct gaaactattc 385800 caaacaacag aaaaagaggg acttctccct aactcatttt atggggccag aatcatcctg 385860 ataccaaaac ccagcagaca tacacacaaa aaagagaaaa cttcagacca atatccctga 385920 tgaacattga tgtgaagatc ctctataaaa tactggcaaa ccaaatccag cagggcatca 385980 aaaagtttat ccaccatgat caagtcggct tcatccctgg gacgcaaggg ctggttcaac 386040 atatgaaaat caataaacat aagccatcat gtaaacagaa ccaatgacaa aattcacatc 386100 atctcagtag atgcaggaaa ggcctttgat aaaattcaac atccctacat gtttaaaact 386160 ctcaataaat tagacattga tggaacatat ctcaaaatga taagagctat ttatgacaaa 386220 cccatagcca atatcatact gagtaggcaa atgcaggcag cattcccttt ggaaactgac 386280 acaagacaag gatgccctct ctcaccactc ctattcaaga tagtattgga agttctggcc 386340 agggcaatca ggcaagagaa agaaataaag cgtattcaaa taggaataga ggaagtcaga 386400 ttgtctcttt tggcagctga catgattcta tatttagaaa accccatctt ctcagccgaa 386460 acacttctta agctgataaa caacttcagg aaagtctcag gatacaaaat caatgtgcaa 386520 aaacgacaag cattcctgta caccaacaat acacaagcag agggccaaat catgaatgaa 386580 cttctgttca caattgctac gaagagaata aaacttacaa ggggtgtgaa ggacttcttc 386640 aaggagaact acaaatcact gctcaagaaa ataagagagg acacaaacaa atggaaaaac 386700 attccatgct catggatggg aagaatcaat atcatgaaaa tggccatact gtccaaagta 386760 atttatagat tcaatgctat tgccatcaag ctaccattga ctttcttcac agaaatagaa 386820 aaaatctact ttaaatttca tatggaatca aaaaagagct ggtatagcca agacaatcct 386880 aagcaaaaat aacaaagctg gaggtatcac gctacctgac ttcaaactat gctacatggc 386940 tacagtaacc aaaacaacat ggtacttgta ccaaaacaga tatacagacc aatggaacag 387000 aacagaggcc tcagaaatat caccacacat atacaacaac ctgatattcg acaaacctga 387060 ccaaagcaat gaggaaagga ttccctattt cataaatagt gctgggaaaa ctggctagcc 387120 atatgcagaa aactgaaact ggacctcttc gatacacctt atagaaaaat taactcaaaa 387180 tggattaaag acttaaatgt aaaaaccaac actgtaaaaa ctctagaaga aaacctaggc 387240 actaccattt aggacatagg cttgggcaaa gacttcatga ctgaaacacc aaaagcaatt 387300 gcaacaaaag ccaaaattta catatgtatc taattaaact aaagagcttc tgcacagaaa 387360 aagaaactag catcaggctg aacaggcaac ctacagaatg ggagaaaatt tctccaatct 387420 acccatctgg caaagttcta atatctagaa tctacaagga acttaaaatt tacaagaaaa 387480 aaacaacccc atcaaaaagt gggtgaagga tatgaacaca cattctcaaa agaacacatt 387540 tatgtggcca agaaacatat gaaaaaaagc tcttcaccac tgatcattag agaaatgcaa 387600 attaaaacca cagtgagata ccatctcatg acagtcagaa tgacgattat taaaagatca 387660 agaaacaaag acgctggcaa ggctgtggag aaacaggaat gcttttacac tgttggtggg 387720 agtgtaaatt agttcaacca ttgtggaaga cagtgtggca attcctcaag aatctggaac 387780 cagaaatacc atttgaccca gcaatcccat tactgggtat atccccaaag gattataaat 387840 cattctacta taaagacaca tgcacatgta tgttcattgc agcactattc acaatagcaa 387900 agacttggaa ccaacacaaa tgcccatcaa tgatagactg gataaagaca atgtagcaca 387960 tgtacaccat ggaatactat gcagccataa aaaagaatga gatcatattc ctttgcaggg 388020 acatggacaa tgctggaagc catcattctc agcaaactaa cacaggaaca gaaaaccaaa 388080 cactgcatgt tctcacttat aagtgggagt tgaacaatga gaacacatgg acacagggag 388140 gggaacaaca cacacccaca cagaggcctg ttggggtagg gggcaagagg agggagagca 388200 ttaggacaaa tacctaatgc atgtggggct taaaagctag atgatgggtt gataggtgca 388260 gcaaaccacc atggtacatg tatacctatg taacaaacct gcacattcta tacatgtatc 388320 ctggaactta aagtgaaata aaaatgaaat aaaataagag agagagagga aacttttaaa 388380 ttccttgaga gaccaaccgt ttcctagaaa cgaatattaa aagaaatatg taatgcaaat 388440 atttattaaa atgacattaa acaatgtaaa catttagtgg cagttttctg agaaaaatgc 388500 aaaaatatac ttcttatata ttcaatccag aatgaaagct tgaaggttta atatgtaact 388560 ctagcaaagt aaaagtattt cagtaagaga cctaaggtga tgagtctctg aaatgtggct 388620 gtattttaat ctaacttaat gagcaatgta gctaagtaca ctcagagcaa tggacctctg 388680 cagttagcat ctctgagtat cttggaacat gattttccca tccaccaact taacagaagc 388740 ttgatgtcaa agagttcaag gttgggcaaa attggggttg tgtccagtct gtatggctga 388800 acacagatct acataatatg aactagatat gcagaaggca aagtaaacat tctgctgtgt 388860 aaacaggaat ctaaatttgc ctaataagaa accaactcaa ttcttacaga ggtaagcctc 388920 tatgatgttt gtaaacctat ttcttttttt caatcaggaa actccattct taactatctt 388980 agacatttct gaataagatt ctagaattct tttcttaacc tgtttatttt gaaaaatttt 389040 aagtttatta taaataaata gtaactatcc atcattcagt ttcaataaaa atcaatatac 389100 agctaaaatt cagaccttct ctctccttct tctcccccaa ctctggattg ttctgaggca 389160 aagcccaaat attataacat ttcctttata aatatttcac tctgtactct gaaaaggtaa 389220 agactatttt taaaagcaca taactataat atcatttccg tatctacaaa caataattgt 389280 caataatttc tgtgatagtt tgtctccaag ataaccctaa ctgattgaat ccttcctttc 389340 cacatgcata tcatttccct gtcaagagat agagagcatt cccctacttt catgaatctg 389400 ggctggcctg cttctacttt tcccaataga atatggcaca agtgaggcta tagaagttct 389460 agaccttgac ctgaagaagc ctgggagttt ccacttcttt tgggagtgct gagccaccac 389520 atcttactac cctgcttaag agaccatagg agagaacata tctatttatt tattgattga 389580 tcaaactatc tatctacata tatagagaga gacccagcca ctccagcatc ttgggtgagc 389640 ccagccttcc aactatcttc atcaaagtac tagacatgtg aatgaagcct tcttggactc 389700 tccacacaag ctcccccacc aactaaacat cactgaatta ccccagttga cattctgtgg 389760 agaagaaaaa ttgactagcc aagacctgcc taaattttgg atccatagaa tcataagtaa 389820 caaaatgact actttaggtc actatgtttt ggtttgattt gatacaagga atagataact 389880 aaaacaattc tgtaatatta tcaatattca gtcaatatac agctttatcc aatcagtttt 389940 taaatatttt ggatagagtt ggttcgtttg aaccaggatt tcaacagata accctagaac 390000 tcaaaacaat aatgaaaata ttttatgcat ctgtaaacat ttcccatttt accaactact 390060 tttataaaaa atatctgatg ttatatggta gctctggata gataggtggt ttttgcaaag 390120 attactatct acattacaca atttttttaa aaaaagaact aggtctagag attaaatggc 390180 atatcagaac aattgtatct ggacttcaaa cccagattgt agaatttaag gtctagtgct 390240 ctttccttta ttccaaacac ttcaaagatt tatattacct gattgggtct aataagattt 390300 gctattattg gaaccataaa gaaacaagta tttctccact cctcatcctt ataccctgag 390360 atgtatctat tctcaaatat atcccctcct ctcaatttct gccacctggt tcctagtgta 390420 ggcttccatt acttccctcc tggcatacca aagtcctaat tgatctctaa gtatctggtc 390480 ttgatcctct ttcatttttc ctccattcca ttgccagatg catctgtcaa aaaccaaact 390540 tggccacctt gattcctctg cctaataata tttaataatt ctcaaactga tatccataga 390600 aagaaatgtt ctcagaaggc cacgagtcct gaaaaatctt caaaattcct gtatcttggt 390660 gaaaatttaa aacaataaat ataagaatct tctgaatcat taagatgatt acctaataac 390720 aaagtactgc catctacctg attacagtaa tgatgactgc atttggattt acctcatgat 390780 gctaatgctt gctatataaa taaagctttt tgaagttgtt tggctattaa aagtcatgag 390840 acaattaaac ggtcacataa aacatgcata atgatgcaga aatcaaaaga accagtacca 390900 taacatttga taccatacca gtttctacaa atgcattgtc aaaacacact ccattgttat 390960 acataccaaa ttgcagtggt tctgtgtcaa tgggcgtatt ggaatacaac acatgaactc 391020 ccagtactaa gagataatgt gtttagataa tcacttaatg tagaattcaa taatgcccta 391080 aagctaaact taagtaaaga aaaatatttg tatagttttc aagtaacacc atttaaattg 391140 gcttttgaag cctaatagga acagagttca cattaagaat taggttagtt tatcatgata 391200 acgcaagtaa atctttgaag ttggtaatac tactctgaca acatactttt tcaaaaaata 391260 cattaagatt agaacagaga aaaatgttgt atctattaga ttaagccata cacaatagtc 391320 aaatttcaat catttttgat ctacagaaat gtcagatatt gagttagtaa tgagagtttg 391380 aattcactgt tttataaata ttttattttc aagtgttttc attttttgtc attgtattag 391440 ttttttcagg gctgccataa taaactacca caagctgagt ggcttaagac aacagaagtt 391500 tatttttgca caattctgtg gtctagaagt ctgaaatcaa gatgtgggca aggttgtttc 391560 cttctggagg ttctgaggga aaatacatcc tgtgcctgtc tctatttgag gttctggtgg 391620 ctgtggacaa tccacagcat tccttggctt gcagctgtat ctgctcccgt gacacatggc 391680 attttggttg tgtgtctttc tgtctctgta tccaaacttc tctcttctta tagggatacc 391740 agttattgga ttaaggccca ccccaaacca ctgtgacctc atcttaactt gatttatatc 391800 tacaaaaacc ctctttccaa ataaagtcac attcataggt actgggaatt atgacttcaa 391860 cacatccttg tagggtacac aatttaaccc acaagtcata ttaagagtta taagcataag 391920 aagttctaat ctgtttttat ttttgaacat atttatctaa cattgtaaat aagaataata 391980 taaatcctgc aataattgtc tttcctttta aaaaaagagc ctgtatatta ttcctgtatg 392040 agaaggttga cctaaagtac agagcctgag atccctatcc agtcacatta gaccttcagc 392100 aacctggaac tggccctctc catggccgtc ctctacccta cttccctggc attttattct 392160 ttagtaaaat ataaggctgc ttacaattcc ccaacacaca acacatgatt ttatgctttc 392220 ttacccttgt tcattctgtc ccctctgctt gtaatatcct tcccttccca acttcctcat 392280 cccttagctg tgtccttttc tgactcctat tcagtctcag ttcaactgcc atcttttccc 392340 aaaaatcctc tgtgaagact acccacctac tccatcagca ccatcaccaa tcccaggccc 392400 tgagtgaagt ggacctcaag gggactccca ttttcccaca catctgtctc caaacagact 392460 acaaactcca agatctcagg gacagtgtct tccccatctt tcaatctcca gctcttagca 392520 cagtggtcat ctgaatgtta aatgaaggtg tgcctgtgtg cctatgtggg atggaaagag 392580 tttcagccac agttccaaga ttgctgtttg cattctaatt catacttctg ctaaaagagg 392640 tattgcaatt gccccatgtg ggaggttagt atcggaagtt tgtcacctaa gcagtgagca 392700 aactcacaca aatatacctg tcattaaaag tgacttattt ttcctctttg attgactaca 392760 cgcctttttt atgaaaaaga tttgtggatt taaggatatg gaaagatctc agcagctcaa 392820 aaattttagt cttgttttgc tggagtgccc tgggtacaca ggaatctaat ggaagaaagg 392880 actagaaaga tggaatgggt ccatatttta aatgacttta atgactttga aagccaaaat 392940 aaagctgtgt attttgcttt ctatatactg agtagttctg cttttctaga aaggaacatg 393000 acatatttcc ttttgtacag accaaaatgt cacacactgg ttctctatac taagcataat 393060 gggatcagag ttctattaat ctgtacttct aaaatgacag ataatttaat tactcccgtt 393120 tggattttga aagtcatata cttatatatg tgtgtatctt ggactttcaa tatttcacag 393180 ataacaaaat cactttattt tccagattgc tcttttgcta ataattagct gccatcattt 393240 ctcataatag cttaaaataa aaccctgttc tctctataaa ctggctggtt caaatttaca 393300 gtggactgat taagtggtca ggtcagattc tttattattt tttgaaaact agttaaagta 393360 gtttagcagt tatcaaaaag cagctttgcc tattttagct gaatcttttg ttatatttaa 393420 aagttatatt gtgtctcatt tggggttatt taactttcaa agtcctttta aaactaggga 393480 tggtaactca ttatgtgggg ataaaaaggt acgagatatg acaataaata taagatttaa 393540 atttcaagta cacgtgacat aattcattac tacagtcaag ttaaaacaac atgaatagaa 393600 ttgccaaaaa cacagaaata acactctctg actaaccaat ggaggattac ctgagatcca 393660 tgctgcaaag ctgatgatgt attaattgtg tttagaacaa tctagtctat ggaaatgtac 393720 tcagtgaaat taactttgaa atagagccat tgtatatgtg tgggatattc atagcattaa 393780 attagaaccc acatttccct ttttaaattg ctctttttat gccatttgtg gagccattac 393840 aaaatttcag ctttttaaaa cccatatatt aaggcttaca ttttacccaa taaattacac 393900 ttactgggta gctaagtaac ctttttgttt tgacttttgt ttttaaaact tagtcttaaa 393960 tcactaaatc atggactttt ctacttggta gagacaaaac tgtactttag ctttcatttt 394020 tttcaggtaa actaaaactc taaaaggtga actgttttag tttatctgat gccttataag 394080 gagaataaat cttggaggtg aagtaccact tggtgtctaa acaccttgca acatttccag 394140 gtcaatattc tgaacatctc cttgtagcat tttctttttg cagttctcta aatgtgatgg 394200 aagggttgga atgcaagtgt atttgtcccg gaatatcaaa tactctctca accttttaag 394260 gaaaagcctc ttttgtgttc attttaatct catttgcctt ttttccccta atgttaaaaa 394320 cagattgcag gtgggaaatt ctgcttaatt aaaatttgaa tgagttgggt ttaatttatc 394380 aaggtgtaat tataaattaa atatatgtaa attaaatgtg accatggatc caagtagact 394440 gcttctattc ataacaacta atcctttcct agatttgaaa actgcattac taatatatca 394500 aaaccaactt tgtgattttc taaaaacagc catgtatttt tacatctgag atgtactacg 394560 ttccaaagga aacagtaaca ttcctcagta tctcagtggc aatatttatt attttttcag 394620 tgaaattcat atttatcaag aaatgccatt gtgattttct tgagccaaat acactgtata 394680 agtttatatg ggtttatgta atgtatgtgt gtgtttcata aatacttcca aattacatga 394740 attctctcta ataaatttta ctgtataatt agttccctta atatttgata ggtttaccag 394800 attaaaaatg gcatatttat gtagtgtatg attttctttt gcacattcag gttctctctt 394860 taggagcaga tgtcctacct gaatacaaac tgcagacacc acgcatcaac aagtttacga 394920 tattgcacta cagccctttc aaggcagtct gggactggct tatcctgctg ttggtcatat 394980 acactgctat atttactccc tactctgcag ccttcctcct caatgacaga gaagaacaga 395040 aaagacgaga atgtggctat tcttgtagcc ctttgaatgt ggtagacttg attgtggata 395100 ttatgtttat catagatatt ttaataaact tcagaacaac atatgtaaat cagaatgaag 395160 aagtggtaag tgatcccgcc aaaatagcaa tacactactt caaaggctgg ttcctgattg 395220 acatggttgc agcaattcct tttgacttgc tgatttttgg atcaggttct gatgaggtaa 395280 gaactgctta agattcttat tttctgaaag attgcaatta taaaagtgaa tctattttaa 395340 ctgcaaaaag aagagttgct ttgcaagctt cttgtatctc actgataaaa ttcattttca 395400 attggggata ctacagaatg aaatgaaacc attttgccat tgcaaatcaa attctttctc 395460 tttttgctaa gagatgcaaa agattctcca ttctttaccc accaaattaa acttggaaac 395520 aagtggtcca tagcacacag cacattccca ggatttaaaa tctctactta ttaacttcac 395580 gggtgtaaaa ctctcaaata ttaagtatgt ctctgttttt cttaactcat tgttaaggtt 395640 tgagacagca gagatttgtt ttttgttcaa attatgtgaa gagggcacct tccgaaatgt 395700 cttattcaaa tatgctttct cttaaataat attcagcttg gaaagtactt tttgtgtatc 395760 ccaatgccta ataaagttgg aaactaagaa aatacgagaa gtgtatgtat tgtgcatttt 395820 ctggatagag agtccagaac tttaatcagc tcctcaaaag actctttgat ccaaaagaag 395880 ttaagttttc ctacagttca cttcatctaa tttccattat ttttaccatt tataaacttt 395940 ctgaattctg taacagaaag atttatagaa tgcttgaaag tagttccaag ggaataggtt 396000 gaaaaaatcc tcgatatgtt ggatttttaa aaattgtgtc tttttctaca taagaaccct 396060 gccctgcacc aacttccttc tctccccaac aaagaggaga ccacctcctc ttggcagatg 396120 gctgcttcct agccaatgaa ggctttagaa caacataatc ctcctcgacc aaggggaacc 396180 aaaagatttt atttctaaat ctatttattt gttagaaata aactctgatc gaactgtgag 396240 tcagttaaga gcagggcaat gaaacaatac atttttcctg ggttctacaa ttttaaacaa 396300 agtcccaacc tgactttcct catctgtaaa aggatgataa taatattacc ttctcctctt 396360 gctttttttt ttctaatttg agactctaat gagatagtac atgtgactca gcaaaatact 396420 ttttaaaaat cagctgttct taattagctg aacttttaat attagctact cctaactttg 396480 ggttttaact aaaagagagt gaaatacttc tttattaata tatatctttg agtttcttat 396540 aatgggtggt tcacatcatt gcaccaaata agcttatgtt gatgaacaat aaaataaaac 396600 ctcattcttt caaaagttaa aatatatgca ccaacagcaa acattagtga tttgtagaca 396660 agcttagaag tataatggga gaagttgtaa gaagtttgtg tcttttaaat tttaaagtct 396720 gaattttaaa atgcactaaa aattctggac ataatgtaag tgttaccccc aaattaaaat 396780 ctagtactgc tgccaatgta gatcttagaa ctagaagtaa ccacaggaaa ttatctagtt 396840 caatcctctg cctaggaagc taaagtacta tttacagaat gagactgttg aaacctagaa 396900 ttgttcagtg atgctctcag ttctattttc tgcattactc ttaattacta atataatact 396960 ttatttattc aaaaattttt tgttaggtac ccttcaaagt gacagccact gtcctaggtt 397020 tagagattca gaagtaaatc agacaaagtt tgtgttgtcc aggaacttac attctagaat 397080 tgaggaagag gggtagggga tggcagaggg caaaagacca ttaataaaca aaccaacaaa 397140 cacagtgcag aaaggtttca ggaaagagta aatgctgtga tgatagcaaa gcaggtggat 397200 gtgatagaga atgacctgga tggatggcta atttgaattg gaaattacaa aaggccagta 397260 aggagaggcc atttgagttg agacttgata ggaagcaacc atccacatga gaccaccgtg 397320 cagagcattt cacacagaag gaaacactag tgaaaatgtc gcatttgggg aacaagtttg 397380 ttatggtaga ggaacagaaa gatggctggt ggctgccagg ctgaaccaca cagtaagagg 397440 tggaatgcta aggtttgaga aggcagagac agagaccaaa tcacctagat atgtgggatt 397500 tcttacttat tctggctgca atggagtctt tggaacagga atgatactat ccgatggaca 397560 ttttgaagac tgcaaaggct gtcatctgca gactggagag tcaggctagg agcagggaac 397620 tagttcagac cacatgttgt gatgcaggac aaaacaac 397658 4 521 PRT Human 4 Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Gly 1 5 10 15 Thr Ile Ile Arg Lys Phe Glu Gly Gln Asn Lys Lys Phe Ile Ile Ala 20 25 30 Asn Ala Arg Val Gln Asn Cys Ala Ile Ile Tyr Cys Asn Asp Gly Phe 35 40 45 Cys Glu Met Thr Gly Phe Ser Arg Pro Asp Val Met Gln Lys Pro Cys 50 55 60 Thr Cys Asp Phe Leu His Gly Pro Glu Thr Lys Arg His Asp Ile Ala 65 70 75 80 Gln Ile Ala Gln Ala Leu Leu Gly Ser Glu Glu Arg Lys Val Glu Val 85 90 95 Thr Tyr Tyr His Lys Asn Gly Ser Thr Phe Ile Cys Asn Thr His Ile 100 105 110 Ile Pro Val Lys Asn Gln Glu Gly Val Ala Met Met Phe Ile Ile Asn 115 120 125 Phe Glu Tyr Val Thr Asp Asn Glu Asn Ala Ala Thr Pro Glu Arg Val 130 135 140 Asn Pro Ile Leu Pro Ile Lys Thr Val Asn Arg Lys Phe Phe Gly Phe 145 150 155 160 Lys Phe Pro Gly Leu Arg Val Leu Thr Tyr Arg Lys Gln Ser Leu Pro 165 170 175 Gln Glu Asp Pro Asp Val Val Val Ile Asp Ser Ser Lys His Ser Asp 180 185 190 Asp Ser Val Ala Met Lys His Phe Lys Ser Pro Thr Lys Glu Ser Cys 195 200 205 Ser Pro Ser Glu Ala Asp Asp Thr Lys Ala Leu Ile Gln Pro Ser Lys 210 215 220 Cys Ser Pro Leu Val Asn Ile Ser Gly Pro Leu Asp His Ser Ser Pro 225 230 235 240 Lys Arg Gln Trp Asp Arg Leu Tyr Pro Asp Met Leu Gln Ser Ser Ser 245 250 255 Gln Leu Ser His Ser Arg Ser Arg Glu Ser Leu Cys Ser Ile Arg Arg 260 265 270 Ala Ser Ser Val His Asp Ile Glu Gly Phe Gly Val His Pro Lys Asn 275 280 285 Ile Phe Arg Asp Arg His Ala Ser Glu Asp Asn Gly Arg Asn Val Lys 290 295 300 Gly Pro Phe Asn His Ile Lys Ser Ser Leu Leu Gly Ser Thr Ser Asp 305 310 315 320 Ser Asn Leu Asn Lys Tyr Ser Thr Ile Asn Lys Ile Pro Gln Leu Thr 325 330 335 Leu Asn Phe Ser Glu Val Lys Thr Glu Lys Lys Asn Ser Ser Pro Pro 340 345 350 Ser Ser Asp Lys Thr Ile Ile Ala Pro Lys Val Lys Asp Arg Thr His 355 360 365 Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 370 375 380 Leu Pro Glu Tyr Lys Leu Gln Thr Pro Arg Ile Asn Lys Phe Thr Ile 385 390 395 400 Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 405 410 415 Leu Val Ile Tyr Thr Ala Ile Phe Thr Pro Tyr Ser Ala Ala Phe Leu 420 425 430 Leu Asn Asp Arg Glu Glu Gln Lys Arg Arg Glu Cys Gly Tyr Ser Cys 435 440 445 Ser Pro Leu Asn Val Val Asp Leu Ile Val Asp Ile Met Phe Ile Ile 450 455 460 Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Gln Asn Glu Glu 465 470 475 480 Val Val Ser Asp Pro Ala Lys Ile Ala Ile His Tyr Phe Lys Gly Trp 485 490 495 Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile Phe 500 505 510 Gly Ser Gly Ser Asp Glu Thr Thr Thr 515 520

Claims

That which is claimed is:

1. An isolated peptide consisting of an amino acid sequence selected from the group consisting of:

(a) an amino acid sequence shown in SEQ ID NO:2;

(b) an amino acid sequence of an allelic variant of an amino acid sequence shown in SEQ ID NO:2, wherein said allelic variant is encoded by a nucleic acid molecule that hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID NOS:1 or 3;

(c) an amino acid sequence of an ortholog of an amino acid sequence shown in SEQ ID NO:2, wherein said ortholog is encoded by a nucleic acid molecule that hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID NOS:1 or 3; and

(d) a fragment of an amino acid sequence shown in SEQ ID NO:2, wherein said fragment comprises at least 10 contiguous amino acids.

2. An isolated peptide comprising an amino acid sequence selected from the group consisting of:

(a) an amino acid sequence shown in SEQ ID NO:2;

3. An isolated antibody that selectively binds to a peptide of claim 2.

4. An isolated nucleic acid molecule consisting of a nucleotide sequence selected from the group consisting of:

(a) a nucleotide sequence that encodes an amino acid sequence shown in SEQ ID NO:2;

(b) a nucleotide sequence that encodes of an allelic variant of an amino acid sequence shown in SEQ ID NO:2, wherein said nucleotide sequence hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID NOS:1 or 3;

(c) a nucleotide sequence that encodes an ortholog of an amino acid sequence shown in SEQ ID NO:2, wherein said nucleotide sequence hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID NOS:1 or 3;

(d) a nucleotide sequence that encodes a fragment of an amino acid sequence shown in SEQ ID NO:2, wherein said fragment comprises at least 10 contiguous amino acids; and

(e) a nucleotide sequence that is the complement of a nucleotide sequence of (a)-(d).

5. An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:

6. A gene chip comprising a nucleic acid molecule of claim 5.

7. A transgenic non-human animal comprising a nucleic acid molecule of claim 5.

8. A nucleic acid vector comprising a nucleic acid molecule of claim 5.

9. A host cell containing the vector of claim 8.

10. A method for producing any of the peptides of claim 1 comprising introducing a nucleotide sequence encoding any of the amino acid sequences in (a)-(d) into a host cell, and culturing the host cell under conditions in which the peptides are expressed from the nucleotide sequence.

11. A method for producing any of the peptides of claim 2 comprising introducing a nucleotide sequence encoding any of the amino acid sequences in (a)-(d) into a host cell, and culturing the host cell under conditions in which the peptides are expressed from the nucleotide sequence.

12. A method for detecting the presence of any of the peptides of claim 2 in a sample, said method comprising contacting said sample with a detection agent that specifically allows detection of the presence of the peptide in the sample and then detecting the presence of the peptide.

13. A method for detecting the presence of a nucleic acid molecule of claim 5 in a sample, said method comprising contacting the sample with an oligonucleotide that hybridizes to said nucleic acid molecule under stringent conditions and determining whether the oligonucleotide binds to said nucleic acid molecule in the sample.

14. A method for identifying a modulator of a peptide of claim 2, said method comprising contacting said peptide with an agent and determining if said agent has modulated the function or activity of said peptide.

15. The method of claim 14, wherein said agent is administered to a host cell comprising an expression vector that expresses said peptide.

16. A method for identifying an agent that binds to any of the peptides of claim 2, said method comprising contacting the peptide with an agent and assaying the contacted mixture to determine whether a complex is formed with the agent bound to the peptide.

17. A pharmaceutical composition comprising an agent identified by the method of claim 16 and a pharmaceutically acceptable carrier therefor.

18. A method for treating a disease or condition mediated by a human transporter protein, said method comprising administering to a patient a pharmaceutically effective amount of an agent identified by the method of claim 16.

19. A method for identifying a modulator of the expression of a peptide of claim 2, said method comprising contacting a cell expressing said peptide with an agent, and determining if said agent has modulated the expression of said peptide.

20. An isolated human transporter peptide having an amino acid sequence that shares at least 70% homology with an amino acid sequence shown in SEQ ID NO:2.

21. A peptide according to claim 20 that shares at least 90 percent homology with an amino acid sequence shown in SEQ ID NO:2.

22. An isolated nucleic acid molecule encoding a human transporter peptide, said nucleic acid molecule sharing at least 80 percent homology with a nucleic acid molecule shown in SEQ ID NOS:1 or 3.

23. A nucleic acid molecule according to claim 22 that shares at least 90 percent homology with a nucleic acid molecule shown in SEQ ID NOS:1 or 3.