US20020064549A1 - Insulin supplemented infant formula - Google Patents
Insulin supplemented infant formula Download PDFInfo
- Publication number
- US20020064549A1 US20020064549A1 US10/015,782 US1578201A US2002064549A1 US 20020064549 A1 US20020064549 A1 US 20020064549A1 US 1578201 A US1578201 A US 1578201A US 2002064549 A1 US2002064549 A1 US 2002064549A1
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- United States
- Prior art keywords
- insulin
- infant formula
- infant
- solution
- human
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
Definitions
- the present invention relates to an infant formula and, more particularly, to an insulin supplemented infant formula.
- Type-1 diabetes which is insulin dependent diabetes mellitus (IDDM)
- IDDM insulin dependent diabetes mellitus
- IDDM insulin dependent diabetes mellitus
- the etiology is multifactorial, with genetic and environmental factors contributing to the autoimmune destruction of the ⁇ cells.
- concordance for IDDM in monozygotic twins is not more than 30-50% (7) and that 90% of patients with newly diagnosed IDDM do not have an affected first-degree relative having IDDM (8), as well as the sudden increase in incidence of IDDM witnessed over the last ten years (9), have been taken as indication of the importance of environmental factors in triggering the development of the autoimmune process in genetically susceptible individuals.
- type I diabetes is related to cow's milk consumption and neonatal feeding practices (2,10).
- case-control studies including a study conducted in the Juvenile Diabetes Unit of the Rambam Medical Center, Haifa, Israel
- patients with type I diabetes were more likely to have been breast-fed for less than 3 months and to have been exposed to cow's milk proteins before 3 months of age (3).
- the immune system of patients with IDDM recognizes cow's milk proteins, as demonstrated by antibodies assays and lymphocytes activity tests (11).
- an infant formula in a powder or solution form comprising nutritional components and an insulin supplement such that when the infant formula is fed to an infant a chance of the infant of developing diabetes is reduced; wherein said insulin is in a concentration range of about 1,000 to 100,000 micro units/100 ml of solution or 8,300-750,000 micro units/100 grams of powder.
- a method of feeding an infant comprising the steps of dissolving an infant formula powder containing nutritional components and an insulin supplement in water for obtaining a solution including the nutritional components and the insulin supplement and feeding the infant with the solution thereby reducing a chance of the infant of developing diabetes; wherein said insulin is in a concentration range of about 1,000 to 100,000 micro units/100 ml of solution or 8,300-75,0000 micro units/100 grams of powder.
- the insulin is recombinant insulin.
- the insulin is synthetic.
- the insulin is purified natural insulin.
- the insulin is biologically active.
- the insulin is in a concentration range of about 17,000 to 400,000 ⁇ U per 100 grams of said powder or 2,000-55,000 ⁇ U per 100 milliliters of said solution.
- the insulin has an amino acid sequence of human insulin.
- At least some of the nutritional components are derived from milk or soy.
- the present invention successfully addresses the shortcomings of the presently known configurations by providing an infant formula which is more similar to human milk, protects from the development of Type-1 diabetes and improve the development and maturation of infants intestine.
- the present invention is of an infant formula supplemented with insulin, preferably human insulin, which can be used to feed infants. Specifically, the present invention can be used to protect infants of syndromes associated with feed devoid of insulin fed to them in the first year of their lives. The present invention renders infant formulas more similar to human milk.
- Addition of insulin to infant formula leads for the following beneficial effects. First, it renders the infant formula more similar to human milk. Second, it protects from the development of Type-1 diabetes. Third, it improve the development and maturation of infants intestine. The addition of insulin to infant formula is safe for at least two reasons. First, the concentration of insulin is selected similar to that found in human milk. Second, oral insulin administration is already used in several human trials (17).
- an infant formula in a powder or solution form which formula includes nutritional components and an insulin supplement.
- a method of feeding an infant is effected by executing the following steps. First an infant formula powder containing nutritional components and an insulin supplement is solubilized in water for obtaining a solution including the nutritional components and the insulin supplement. Second, the solution is fed to the infant.
- the nutritional components may include milk or soy derived nutritional components. They may additionally include one or more of the following ingredients: lactose, vegetable oils, skimmed milk powder, whey protein concentrate, Sodium, Calcium, Phosphorus, Potassium, Chloride, Iron, Magnesium, Taurine, Vitamins, Glucose syrup, soy protein isolate, Sucrose, Maltodextrine, Methionine, Taurine, Carnitine, and trace elements.
- the insulin is selected from the following insulin types: recombinant insulin, synthetic insulin, purified natural insulin, biologically active insulin and insulin having an amino acid sequence of human insulin (e.g., human insulin). Some of these types are overlapping and therefore the insulin of choice may be categorized to more than a single type of the types listed.
- Human recombinant insulin is available in a pure form from Eli Lilly & Co, USA.
- Human natural purified insulin is available in a pure form from Novo Nordisk, Denmark. Crude extracts may also be useful, depending on the method of their manufacturing.
- Synthetic insulin may be manufactured using commercially available building units for Boc and Fmoc chemistry peptide synthesis, as well known in the art.
- the concentration of the insulin in the solution is similar to the concentration in human milk.
- the insulin concentration is in the range of about 25000-75000 ⁇ U per 100 grams of the powder (which is diluted about 7.5 fold to form the solution) or 3000-10000 ⁇ U per 100 milliliters of the solution, preferably 3000-6000, optimally about 4200 ⁇ U per 100 milliliters of the solution.
- insulin concentration is significantly higher in human milk (about 42 ⁇ U/ml) compared with commercial fresh cow milk (about 17 ⁇ U/ml) and infant formulas (about 4-12 ⁇ U/ml). Insulin levels in infant formulas is very low and is similar to the levels recorded for negative control solution (0.5% bovine serum albumin solution, about 6 ⁇ U/ml).
- Tables 2 and 3 below provide exemplary compositions of dry and in solution milk- and soy-bases infant formulas according to the present invention.
- the formula comprises the following ingredients: lactose, vegetable oils, skimmed milk powder, whey protein concentrate, Sodium, Calcium, Phosphorus, Potassium, Chloride, Iron, Magnesium, Taurine, Vitamins and Insulin.
- TABLE 2 Powder Solution Unit 100 g 100 ml General Comp. Protein gram 11.1 1.5 Fat gram 25.9 3.5 Lactose gram 55.5 7.5 Water gram 2.5 — Ash gram 2.06 0.27 Insulin ⁇ U 22500-75000 3000-10000 Vitamins Vitamin A I.U. 1500 200 Vitamin D I.U.
- Vitamin B mg 6 0.81 Vitamin K ⁇ g 15 2.01 Vitamin B1 ⁇ g 350 47.03 Vitamin B2 ⁇ g 450 60 Vitamin B6 ⁇ g 222 30 Vitamin B12 ⁇ g 0.66 0.09 Niacin mg 2 0.27 Folic Acid ⁇ g 45 6 Calcium mg 4.44 0.06 Pantothenate Biotin ⁇ g 11 1.5 Vitamin C mg 45 6.08 Minerals Calcium mg 326 44 Phosphorus mg 219 29.6 Magnesium mg 37 5 Iron mg 7.4 1 Sodium mg 120.7 16.3 Potassium mg 373 50 Cal ratio — 1.49 1.49 Amino Acid Profile Alanine mg 522 69.6 Arginine mg 368 49.1 Asparatic Acid mg 11.10 1.5 Cystine mg 191 25.5 Glutamic Acid mg 1423 189.7 Glycine mg 244 32.5 Histidine mg 262 34.9 Isoleucine mg 761 101.5 Leucine mg 12.20 1.62 Lysine mg 10.00 1.3 Methionine mg 270 36 Phenylalanine mg 461 6
- the formula comprises the following ingredients: Glucose syrup, vegetable oils, soy protein isolate, Sucrose, Maltodextrine, Sodium, Calcium, Phosphorus, Potassium, chloride, Iron, Magnesium, Vitamins, Methionine, Taurine, Camitine, trace elements and Insulin.
- TABLE 3 Powder Solution Unit 100 g 100 ml General Comp. Protein gram 15 1.98 Fat gram 27.54 3.64 Carbohydrate gram 51.5 6.8 Linoleic Acid gram 4.5 0.6 Insulin ⁇ U 22500-75000 3000-10000 Vitamins Vitamin A I.U. 1500 198 Vitamin D I.U. 300 39.7 Vitamin E I.U.
- Vitamin C mg 65 8.6 Vitamin K ⁇ g 77 10.2 Vitamin B1 ⁇ g 345 45.6 Vitamin B2 ⁇ g 445 58.9 Vitamin B6 ⁇ g 327 43.3 Vitamin B12 ⁇ g 1.5 0.2 Niacin mg 7 0.93 Folic Acid ⁇ g 76 10 Pantothenic Acid ⁇ g 4.5 0.6 Biotin ⁇ g 25 3.3 Choline mg 58 7.7 Minerals Calcium mg 500 66.2 Phosphoms mg 300 39.7 Magnesium mg 45 6 Iron mg 9.2 1.2 Zinc mg 4 0.53 Manganese pg 150 19.8 Copper ⁇ g 400 53 Iodine ⁇ g 77 10.2 Sodium mg 200 26.5 Potassium mg 546 72.2 Chloride mg 400 53 Inositol mg 25 3.3 Carnitine mg 10 1.3 Ca/P ratio 1.67 1.67 Amino Acid Profile Alanine mg 640 85.3 Arginine mg 497 6.5 Aspartic Acid mg 1385 184.7 Cystine mg 242 32.3 Glutamic Acid mg 3065 4
- Eisenbarth G Autoimmune beta cell insufficiency: Diabetes mellitus type 1.
- Fava D Leslie D, Pozzilli P. Relationship between dairy product consumption and incidence of IDDM in childhood in Italy. Diabetes Care 17:1488-1490, 1994.
Abstract
Description
- This application is a continuation in part of U.S. patent application Ser. No. 09/701,652 filed in Nov. 30, 2000.
- The present invention relates to an infant formula and, more particularly, to an insulin supplemented infant formula.
- Breastfeeding, the natural feeding mode, has multiple beneficial effects on the infant. First, it is known to be the most suitable diet for infant's nutritional requirements. Second, it provides the infant with immune protection against a wide range of infection related diseases (1). Third, as it contains active insulin molecules it protects the infant against the development of Type-1 diabetes (2-3). Fourth, insulin present in milk enhances small intestinal growth and development (4).
- Type-1 diabetes, which is insulin dependent diabetes mellitus (IDDM), is the consequence of progressive autoimmune pancreatic β cell destruction during an initially asymptomatic period that may extend many years (5-6). The etiology is multifactorial, with genetic and environmental factors contributing to the autoimmune destruction of the β cells. The fact that concordance for IDDM in monozygotic twins is not more than 30-50% (7) and that 90% of patients with newly diagnosed IDDM do not have an affected first-degree relative having IDDM (8), as well as the sudden increase in incidence of IDDM witnessed over the last ten years (9), have been taken as indication of the importance of environmental factors in triggering the development of the autoimmune process in genetically susceptible individuals.
- Many studies show that type I diabetes is related to cow's milk consumption and neonatal feeding practices (2,10). In the case-control studies (including a study conducted in the Juvenile Diabetes Unit of the Rambam Medical Center, Haifa, Israel), patients with type I diabetes were more likely to have been breast-fed for less than 3 months and to have been exposed to cow's milk proteins before 3 months of age (3). Moreover, the immune system of patients with IDDM recognizes cow's milk proteins, as demonstrated by antibodies assays and lymphocytes activity tests (11). These data emphasize the importance of diet and orally administered proteins on the development of autoimmune diabetes.
- In animal models, It has been shown that oral feeding of a specific antigen can suppress the immune system and cause an antigen-specific reduction in many types of immune responses, including T cell proliferation; delayed type hypersensitivity, and antibody production (12-15). Oral administration of insulin generates active cellular mechanisms that suppress the development of autoimmune diabetes (16). These results have paved the way to the “oral tolerance approach” and oral insulin treatment is already taking place in human trials planned to prevent type 1 diabetes in high risk groups (17).
- As shown below, prior art infant formulas, although attempting to mimic as much as possible breast milk, are very low in immunologically recognizable insulin as compared with human milk. The level of active insulin in these formulas is probably zero, due to the harsh conditions associated with their manufacture.
- There is thus a widely recognized need for, and it would be highly advantageous to have, an infant formula supplemented with insulin.
- According to one aspect of the present invention there is provided an infant formula in a powder or solution form comprising nutritional components and an insulin supplement such that when the infant formula is fed to an infant a chance of the infant of developing diabetes is reduced; wherein said insulin is in a concentration range of about 1,000 to 100,000 micro units/100 ml of solution or 8,300-750,000 micro units/100 grams of powder.
- According to another aspect of the present invention there is provided a method of feeding an infant comprising the steps of dissolving an infant formula powder containing nutritional components and an insulin supplement in water for obtaining a solution including the nutritional components and the insulin supplement and feeding the infant with the solution thereby reducing a chance of the infant of developing diabetes; wherein said insulin is in a concentration range of about 1,000 to 100,000 micro units/100 ml of solution or 8,300-75,0000 micro units/100 grams of powder.
- According to further features in preferred embodiments of the invention described below, the insulin is recombinant insulin.
- According to still further features in the described preferred embodiments the insulin is synthetic.
- According to still further features in the described preferred embodiments the insulin is purified natural insulin.
- According to still further features in the described preferred embodiments the insulin is biologically active.
- According to still further features in the described preferred embodiments the insulin is in a concentration range of about 17,000 to 400,000 μU per 100 grams of said powder or 2,000-55,000 μU per 100 milliliters of said solution.
- According to still further features in the described preferred embodiments the insulin has an amino acid sequence of human insulin.
- According to still further features in the described preferred embodiments at least some of the nutritional components are derived from milk or soy.
- The present invention successfully addresses the shortcomings of the presently known configurations by providing an infant formula which is more similar to human milk, protects from the development of Type-1 diabetes and improve the development and maturation of infants intestine.
- The present invention is of an infant formula supplemented with insulin, preferably human insulin, which can be used to feed infants. Specifically, the present invention can be used to protect infants of syndromes associated with feed devoid of insulin fed to them in the first year of their lives. The present invention renders infant formulas more similar to human milk.
- The principles and operation of an infant formula according to the present invention may be better understood with reference to the drawings and accompanying descriptions.
- Before explaining at least one embodiment of the invention in detail, it is to be understood that the invention is not limited in its application to the details of construction and the arrangement of the components set forth in the following description or illustrated in the drawings. The invention is capable of other embodiments or of being practiced or carried out in various ways. Also, it is to be understood that the phraseology and terminology employed herein is for the purpose of description and should not be regarded as limiting.
- Epidemiological and experimental animal data suggest that insulin content in infant diet may play an important role in preventing autoimmune diabetes and improving intestinal development.
- It is shown in the Examples section hereinunder that the level of immunologically recognized insulin in a variety of commonly used infant formulas is very low, at least four to ten times lower as compared with human milk, probably even lower. Although not tested, the level of active insulin in such formulas is expected to be zero due to the harsh conditions associated with their manufacture. Soy-based infant formulas, are devoid of milk content, and are therefore completely devoid of both immunologically recognizable insulin, not to mention active insulin.
- Moreover, it has been shown that exposure to bovine insulin present in fresh cow milk, which differs from human insulin only by three amino acids, may break the tolerance to insulin and lead to autoimmune diabetes (18).
- To overcome these two obstacles in infant feeding: the lack of insulin in infant formulas and the risk to break immune tolerance to insulin when using fresh cow milk, it is herein suggest for the first time to add human insulin to infant formula.
- Addition of insulin to infant formula leads for the following beneficial effects. First, it renders the infant formula more similar to human milk. Second, it protects from the development of Type-1 diabetes. Third, it improve the development and maturation of infants intestine. The addition of insulin to infant formula is safe for at least two reasons. First, the concentration of insulin is selected similar to that found in human milk. Second, oral insulin administration is already used in several human trials (17).
- Thus, in accordance with one aspect of the present invention there is provided an infant formula in a powder or solution form which formula includes nutritional components and an insulin supplement.
- In accordance with another aspect of the present invention there is provided a method of feeding an infant. The method is effected by executing the following steps. First an infant formula powder containing nutritional components and an insulin supplement is solubilized in water for obtaining a solution including the nutritional components and the insulin supplement. Second, the solution is fed to the infant.
- As exemplified in the Examples section below, the nutritional components may include milk or soy derived nutritional components. They may additionally include one or more of the following ingredients: lactose, vegetable oils, skimmed milk powder, whey protein concentrate, Sodium, Calcium, Phosphorus, Potassium, Chloride, Iron, Magnesium, Taurine, Vitamins, Glucose syrup, soy protein isolate, Sucrose, Maltodextrine, Methionine, Taurine, Carnitine, and trace elements.
- According to a preferred embodiment of the present invention, the insulin is selected from the following insulin types: recombinant insulin, synthetic insulin, purified natural insulin, biologically active insulin and insulin having an amino acid sequence of human insulin (e.g., human insulin). Some of these types are overlapping and therefore the insulin of choice may be categorized to more than a single type of the types listed. Human recombinant insulin is available in a pure form from Eli Lilly & Co, USA. Human natural purified insulin is available in a pure form from Novo Nordisk, Denmark. Crude extracts may also be useful, depending on the method of their manufacturing. Synthetic insulin may be manufactured using commercially available building units for Boc and Fmoc chemistry peptide synthesis, as well known in the art.
- According to another preferred embodiment of the present invention the concentration of the insulin in the solution is similar to the concentration in human milk. Thus, according to a preferred embodiment the insulin concentration is in the range of about 25000-75000 μU per 100 grams of the powder (which is diluted about 7.5 fold to form the solution) or 3000-10000 μU per 100 milliliters of the solution, preferably 3000-6000, optimally about 4200 μU per 100 milliliters of the solution.
- Reference is now made to the following examples, which together with the above descriptions, illustrate the invention in a non limiting fashion.
- Milk Samples and insulin measurements:
- Human breast milk samples were collected from mothers between the second and the 30th day after delivery of full term pregnancies. Cow milk samples were taken from pooled fresh commercially available milk. Cow milk formulas were prepared according to manufacturer instructions. All samples were stored in polypropylene tubes at −20° C. Fat-free infranatant were obtained by diluting the milk samples with PBS (10 mM KH2PO4, 0.15 M NaCl, pH 7.4) and centrifuged at 100,000 g for 60 min. Clear infranatant were aspirated and stored at −20° C. Insulin concentrations were determined by radioimmunoassay with commercial kit (Bio Data, Sorin) using human insulin as standard.
- As shown in Table 1 below, insulin concentration is significantly higher in human milk (about 42 μU/ml) compared with commercial fresh cow milk (about 17 μU/ml) and infant formulas (about 4-12 μU/ml). Insulin levels in infant formulas is very low and is similar to the levels recorded for negative control solution (0.5% bovine serum albumin solution, about 6 μU/ml).
TABLE 1 Insulin concentration in milk samples Insulin Concentration Milk Sample (mean in μU/ml) Human milk, n = 29 42 Fresh pooled cow milk, n = 4 17.08 (Tnuvah, Israel) Materna Premium, n = 2 7.5 (Trima, Israel) Remedia Formula, n = 3 7.0 (Humna Milchwerke ,Germany) Similac, n = 2 11.85 (Ross-Abbott, Irland) Enfalac Premature, n = 1 5.2 (Mead Johnson, USA) Pregestimil, n = 2 3.8 (Mead Johnson, USA) 0.5% Bovine Serum Albumin 6.5 solution, n = 2 (Sigma, USA) - Tables 2 and 3 below provide exemplary compositions of dry and in solution milk- and soy-bases infant formulas according to the present invention.
- The formula comprises the following ingredients: lactose, vegetable oils, skimmed milk powder, whey protein concentrate, Sodium, Calcium, Phosphorus, Potassium, Chloride, Iron, Magnesium, Taurine, Vitamins and Insulin.
TABLE 2 Powder Solution Unit 100 g 100 ml General Comp. Protein gram 11.1 1.5 Fat gram 25.9 3.5 Lactose gram 55.5 7.5 Water gram 2.5 — Ash gram 2.06 0.27 Insulin μU 22500-75000 3000-10000 Vitamins Vitamin A I.U. 1500 200 Vitamin D I.U. 300 40 Vitamin B mg 6 0.81 Vitamin K μg 15 2.01 Vitamin B1 μg 350 47.03 Vitamin B2 μg 450 60 Vitamin B6 μg 222 30 Vitamin B12 μg 0.66 0.09 Niacin mg 2 0.27 Folic Acid μg 45 6 Calcium mg 4.44 0.06 Pantothenate Biotin μg 11 1.5 Vitamin C mg 45 6.08 Minerals Calcium mg 326 44 Phosphorus mg 219 29.6 Magnesium mg 37 5 Iron mg 7.4 1 Sodium mg 120.7 16.3 Potassium mg 373 50 Cal ratio — 1.49 1.49 Amino Acid Profile Alanine mg 522 69.6 Arginine mg 368 49.1 Asparatic Acid mg 11.10 1.5 Cystine mg 191 25.5 Glutamic Acid mg 1423 189.7 Glycine mg 244 32.5 Histidine mg 262 34.9 Isoleucine mg 761 101.5 Leucine mg 12.20 1.62 Lysine mg 10.00 1.3 Methionine mg 270 36 Phenylalanine mg 461 62.3 Proline mg 962 128.3 Serine mg 681 90.8 Taurine mg 37 4.9 Threonine mg 686 91.5 Tryptophan mg 180 24 Tyrosine mg 463 61.7 Valine mg 775 103.3 Fatty Acid Profile Caprylic (C8) % from fa 2.6 2.6 Capric (C10) % 2.1 2.1 Lauric (C12) % 17.5 17.5 Meristic (C14) % 6.7 6.7 Palmitic (C16) % 11.2 11.2 Stearic (C18) % 11.8 11.8 Oleic (C18:1) % 37.0 37.0 Linoleic (C18:2) % 10.0 10.0 Linolenic (C18:3) % 1.2 1.2 Supplement Insulin μU 22500-75000 3000-10000 - The formula comprises the following ingredients: Glucose syrup, vegetable oils, soy protein isolate, Sucrose, Maltodextrine, Sodium, Calcium, Phosphorus, Potassium, chloride, Iron, Magnesium, Vitamins, Methionine, Taurine, Camitine, trace elements and Insulin.
TABLE 3 Powder Solution Unit 100 g 100 ml General Comp. Protein gram 15 1.98 Fat gram 27.54 3.64 Carbohydrate gram 51.5 6.8 Linoleic Acid gram 4.5 0.6 Insulin μU 22500-75000 3000-10000 Vitamins Vitamin A I.U. 1500 198 Vitamin D I.U. 300 39.7 Vitamin E I.U. 10 1.32 Vitamin C mg 65 8.6 Vitamin K μg 77 10.2 Vitamin B1 μg 345 45.6 Vitamin B2 μg 445 58.9 Vitamin B6 μg 327 43.3 Vitamin B12 μg 1.5 0.2 Niacin mg 7 0.93 Folic Acid μg 76 10 Pantothenic Acid μg 4.5 0.6 Biotin μg 25 3.3 Choline mg 58 7.7 Minerals Calcium mg 500 66.2 Phosphoms mg 300 39.7 Magnesium mg 45 6 Iron mg 9.2 1.2 Zinc mg 4 0.53 Manganese pg 150 19.8 Copper μg 400 53 Iodine μg 77 10.2 Sodium mg 200 26.5 Potassium mg 546 72.2 Chloride mg 400 53 Inositol mg 25 3.3 Carnitine mg 10 1.3 Ca/P ratio 1.67 1.67 Amino Acid Profile Alanine mg 640 85.3 Arginine mg 497 6.5 Aspartic Acid mg 1385 184.7 Cystine mg 242 32.3 Glutamic Acid mg 3065 408.7 Glycine mg 300 40 Histidine mg 382 50.9 Isoleucine mg 893 119.1 Leucine mg 1600 213.3 Lysine mg 1360 181.3 Methionine mg 406 54.1 Phenylalanine mg 650 86.7 Proline mg 1113 148.4 Serine mg 737 98.3 Taurine mg 51 6.8 Threonine mg 460 61.3 Tyrosine mg 621 82.8 Valine mg 947 126.3 Fatty Acid Profile Caprylic (C8) % from fa 2.6 2.6 Capric (C10) % 2.1 2.1 Lauric (C12) % 17.5 17.5 Meristic (C14) % 6.7 6.7 Palmitic (C16) % 11.2 11.2 Stearic (C18) % 11.8 11.8 Oleic (C18:1) % 37.0 37.0 Linoleic (C18:2) % 10.0 10.0 Linolenic (C18:3) % 1.2 1.2 Supplement Insulin μU 22500-75000 3000-40000 - Although the invention has been described in conjunction with specific embodiments thereof, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art. Accordingly, it is intended to embrace all such alternatives, modifications and variations that fall within the spirit and broad scope of the appended claims.
- 1. Wold A E, Hanson L A. Defense factors in human milk. Curr Opin Gastroenterol 10:652-8, 1994.
- 2. Kostraba J. What can epidemiology tell us about the role of infant diet in the etiology of IDDM?. Diabetes Care 17:87-91, 1994.
- 3. Verge C, Howard N, Irwig L, Simpson J, Mackerras D, Silink M. Environmental factors in childhood IDDM. Diabetes Care 17:1381-1388, 1994.
- 4. Shulman R J. Oral insulin increases small intestinal mass and disaccharidase activity in the newborn miniature pig. Pediatr Res 28:171-5, 1990.
- 5. Gorsuch A N, Spencer K N, Lister J, McNally J M, Bottazzo G F, Cudworth A G: Evidence for a long prediabetic period in type 1 (insulin-dependent) Diabetes.Lancet ii:1363-1365, 1981.
- 6. Eisenbarth G: Autoimmune beta cell insufficiency: Diabetes mellitus type 1.Triangle 23:111-124, 1984.
- 7. Barnett A H, Eff C, Leslie R D G, Pyke D A. Diabetes in identical twins: a study of 200 pairs:Diabetologia 20:87-93, 1983.
- 8. LaPorte R E, Cruickshanks K J. Incidence and risk factors for insulin dependent diabetes. In: National Diabetes Data Group. Diabetes in America: diabetes data compiled 1984. Bethesda, Md.: Department of health and human services, III-1-III-12. (NIH publication no. 85-1468.), 1985.
- 9. Laron Z, Shamis I, Gordon O, Albaz Y: Increased incidence of childhood IDDM (0-17 yr) in Israel.J Ped Endocrinol Met 8:224, 1995.
- 10. Fava D, Leslie D, Pozzilli P. Relationship between dairy product consumption and incidence of IDDM in childhood in Italy. Diabetes Care 17:1488-1490, 1994.
- 11. Karjalainen J, Martin J M, Knip M, Ilonen J, Dosch H-M. A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N Engl J Med 327:302-307, 1992.
- 12. Weiner H L. Oral tolerance for the treatment of autoimmune diseases. Annu Rev Med 48:341-351, 1997.
- 13. Garside P, Mowat A M. Mechanisms of oral tolerance. Crit Rev Immunol 17:119, 1997.
- 14. Ke Y, Kapp J A. Oral antigen inhibits priming of CD8+ CTL, CD4+ T cells, and antibody responses while activating CD8+ suppressor T cells. J Immunol 156:916-21, 1996.
- 15. Bergerot I, Fabien N, Maguer V, Thivolet C. Oral administration of human insulin to NOD mice generates CD4+ T cells that suppress adoptive transfer of diabetes. J Autoimmun 7:65-71, 1994.
- 16. Zhang Z J, Davidson L, Eisenbarth G, Weiner H L. Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc Natl Acad Sci USA 80:10252-10256, 1991.
- 17. Schatz D A, Rogers D G, Brouhard B H. Prevention of insulin-dependent diabetes mellitus: an overview of three trials. Cleve Clin J Med 63:270-4, 1996.
- 18. Vaarala O, Paronen J, Otonkoski T, Akerblom H K. Cow milk feeding induces antibodies to insulin in children—A link between cow milk and Insulin-Dependent Diabetes Mellitus? Scand J Immunol 47:131-135, 1998.
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