US20020003122A1 - Cylindrical vial with bottom for medicine - Google Patents

Cylindrical vial with bottom for medicine Download PDF

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Publication number
US20020003122A1
US20020003122A1 US09/881,368 US88136801A US2002003122A1 US 20020003122 A1 US20020003122 A1 US 20020003122A1 US 88136801 A US88136801 A US 88136801A US 2002003122 A1 US2002003122 A1 US 2002003122A1
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United States
Prior art keywords
cylindrical vial
vial
conical
core pin
cylindrical
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US09/881,368
Inventor
Morihiro Sudo
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Daikyo Seiko Ltd
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Daikyo Seiko Ltd
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Publication date
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Assigned to DAIKYO SEIKO LTD. reassignment DAIKYO SEIKO LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SUDO, MORIHIRO
Publication of US20020003122A1 publication Critical patent/US20020003122A1/en
Priority to US10/143,409 priority Critical patent/US6756008B2/en
Abandoned legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/0223—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by shape
    • B65D1/0261—Bottom construction

Definitions

  • the present invention relates to a cylindrical vial, with a bottom for a medicine, in which an opening is closed by a rubber closure (needle-penetrable rubber closure) which can be penetrated therethrough with a syringe needle.
  • a rubber closure needle-penetrable rubber closure
  • a vial for a medicine is in the form of a cylinder with a bottom.
  • the vial is provided at its one end with an opening which is closed by a rubber closure made of a rubber material, such as butyl rubber, after the vial is filled with a predetermined quantity of liquid medicament.
  • a syringe needle is penetrated into the rubber closure to aspirate the liquid medicament into the syringe.
  • the internal liquid medicament of the vial must be completely transferred into the syringe.
  • a dosage of liquid medicament is contained in the vial, and hence, if the entirety of the liquid medicament contained in the vial fails to be aspirated, there is a possibility that the expected effect of the dosage of liquid medicament is not achieved.
  • the inventors have conceived that if the needle which is penetrated into a vial through a needle-penetrable rubber closure is automatically brought to the deepest or innermost portion of the vial on the center axis thereof, it is possible to easily aspirate the whole quantity of liquid medicament in the vial into the syringe.
  • a cylindrical vial having a bottom for a medicine, in which an open end of the cylindrical vial is sealed by a needle-penetrable rubber closure through which a needle can be penetrated, the cylindrical vial including a conical bottom end provided opposite to the open end, wherein the apex of the conical bottom end is located on a central axis of the cylindrical vial at the bottommost point inside the cylindrical vial.
  • a conventional cylindrical vial having a bottom is made of a resin material by blow molding.
  • the cylindrical vial is formed using an injection molding die assembly including a core pin, the core pin being in the form of a rod having a uniform diameter and having a conical front end.
  • Dies other than the core pin are not limited to a specific shape or structure and can be of any structure.
  • the cylindrical vial is formed using an injection molding die assembly including a core pin, the core pin being in the form of a tapered rod having a conical front end and having an outer diameter gradually increasing from the conical front end toward the other end thereof.
  • Dies other than the core pin are not limited to a specific shape or structure and can be of any structure.
  • the conical bottom end of the cylindrical vial preferably defines an angle in the range of 30° through 70° between the generatrix of the conical bottom end and the central axis of the cylindrical vial. If the angle is less than 30°, it is necessary to increase the length of the cylindrical vial in order to provide the same capacity as that of a conventional cylindrical vial, and there is a possibility that the needle cannot reach the deepest or innermost portion of the cylindrical vial. Furthermore, since the mass of resin of which the bottom portion of the cylindrical vial is increased, the cylindrical vial becomes heavy. If the angle exceeds 70°, no effect expected from the conical shape can be obtained.
  • a cylindrical vial for a medicine including an axial hollow portion, an open end connected to the axial hollow portion and a closed end opposite to the open end.
  • the open end is sealed by a needle-penetrable rubber closure through which a needle can be penetrated into the cylindrical vial.
  • the closed end includes a conical bottom end, the apex of the conical bottom end being located on a central axis of the axial hollow portion at the bottommost point inside the axial hollow portion.
  • the axial hollow portion is formed using an injection molding die assembly including a core pin, the core pin being in the form of a rod having a uniform diameter and having a conical front end.
  • the axial hollow portion is formed using an injection molding die assembly including a core pin, the core pin being in the form of a tapered rod having a conical front end and having an outer diameter gradually increasing from the conical front end toward the other end thereof.
  • the conical bottom end of the cylindrical vial defines an angle in the range of 30° through 70° between the generatrix of the conical bottom end and the central axis of the axial hollow portion.
  • FIG. 1 is a longitudinal sectional view of an embodiment of a vial for a medicine in which an open end is sealed by a needle stickable rubber closure, according to the present invention
  • FIG. 2 is an enlarged view of a lower portion of FIG. 1;
  • FIG. 3 is a schematic sectional view of an injection molding die assembly for producing a vial for a medicine, according to the present invention.
  • FIG. 1 shows a bottomed cylindrical vial 10 which is filled with a liquid medicament, according to an embodiment of the present invention.
  • the cylindrical vial 10 is long and elongated and is provided with a closed end and an open end 11 which is closed by a rubber closure (needle-penetrable rubber closure) 20 .
  • the rubber closure 20 is provided on its center portion with a reduced thickness portion 21 through which a needle of a syringe can be penetrated.
  • the rubber closure 20 is secured, in a liquid-tight fashion, to the open end 11 by a retainer (rubber closure holding member) 22 .
  • the axial hollow portion 12 of the bottomed cylindrical vial 10 has a rotationally symmetrical shape with respect to the axis 10 X of the cylindrical vial 10 and has a uniform diameter over the overall length thereof from the open end 11 to a conical bottom 13 thereof.
  • the conical bottom 13 is deepest at the apex of the cone located on the axis 10 X and gradually decreases the depth toward the periphery thereof.
  • the angle ⁇ (FIG. 2) defined between the generatrix of the conical bottom 13 and the axis 10 X is preferably in the range of 30° to 70°, from the viewpoint of facilitation of use, and is more preferably in the range of 40° to 60°.
  • the bottomed cylindrical vial 10 is made of a resin material by injection molding.
  • FIG. 3 schematically shows an injection molding die assembly.
  • the injection molding die assembly 30 is provided with a core pin (rod-like central die) 32 in the form of a rod whose diameter corresponds to the inner diameter of the axial hollow portion 12 and which has a conical front end 31 corresponding to the conical bottom 13 , and a pair of right and left split dies 33 and 34 which define therebetween a molding cavity 10 M for the bottomed cylindrical vial 10 , together with the core pin 32 .
  • At least one of the split dies 33 and 34 is provided with a gate 35 through which a molding resin material is introduced into the molding cavity.
  • Various split structures of the split dies 30 to define the molding cavity 10 M can be used, provided that the axial hollow portion 12 is formed by the core pin 32 , and that the core pin 32 is provided on its front end with the conical portion 31 corresponding to the conical bottom 13 .
  • the bottomed cylindrical vial 10 for a medicine which is formed by the injection molding die assembly 30 , is washed and is subject to other necessary operations. Subsequently, a liquid medicament is filled in the axial hollow portion 12 of the cylindrical vial 10 . Thereafter, the needle-penetrable rubber closure 20 is attached to the open end 11 of the cylindrical vial 10 and is secured thereto by a retainer 22 to seal the open end.
  • a needle 40 attached to a syringe is penetrated into the cylindrical vial 10 through the thin portion 21 of the rubber closure 20 .
  • the retraction (inward movement) of a plunger in the syringe causes the liquid medicament in the cylindrical vial 10 to be aspirated into the syringe.
  • the needle 40 is inserted up to the innermost portion of the cylindrical vial 10 , the front end of the needle 40 naturally moves to the apex of the cone of the conical bottom 13 while being guided by the conical surface. Since the liquid medicament in the cylindrical vial 10 is collected in the conical bottom 13 , substantially all of the liquid medicament in the cylindrical vial 10 can be aspirated by the syringe without needing to incline the cylindrical vial 10 .
  • the core pin 32 of the molding die assembly 30 shown in FIG. 3 has a uniform diameter, it is possible to provide the core pin 32 with a tapered peripheral surface for easy release thereof.
  • the core pin 32 can be in the form of a slightly tapered rod whose outer diameter is gradually increased from the conical end 31 toward the other end. The taper angle should be as small as possible.

Abstract

A cylindrical vial having a bottom, for a medicine, in which an open end of the cylindrical vial is sealed by a needle-penetrable rubber closure through which a needle can be penetrated, the cylindrical vial including a conical bottom end provided opposite to the open end, wherein the apex of the conical bottom end is located on a central axis of the cylindrical vial at the bottommost point inside the cylindrical vial.

Description

    BACKGROUND OF THE INVENTION
  • 1. Field of the Invention [0001]
  • The present invention relates to a cylindrical vial, with a bottom for a medicine, in which an opening is closed by a rubber closure (needle-penetrable rubber closure) which can be penetrated therethrough with a syringe needle. [0002]
  • 2. Description of the Related Art [0003]
  • In general, a vial for a medicine is in the form of a cylinder with a bottom. The vial is provided at its one end with an opening which is closed by a rubber closure made of a rubber material, such as butyl rubber, after the vial is filled with a predetermined quantity of liquid medicament. When the liquid medicament is used, a syringe needle is penetrated into the rubber closure to aspirate the liquid medicament into the syringe. In the aspiration operation, the internal liquid medicament of the vial must be completely transferred into the syringe. Namely, a dosage of liquid medicament is contained in the vial, and hence, if the entirety of the liquid medicament contained in the vial fails to be aspirated, there is a possibility that the expected effect of the dosage of liquid medicament is not achieved. [0004]
  • Therefore, a doctor or nurse carefully carries out the aspiration operation of the liquid medicament in the vial. In a conventional vial, in order to aspirate the liquid medicament in the vial completely, it is necessary to incline the vial at the end of the inspiration operation and to move the front end of the syringe needle to the deepest portion of the vial, i.e., the corner portion of the bottom of the vial to thereby aspirate the liquid medicament remaining therein. [0005]
  • It is an object of the present invention to provide a cylindrical vial with a bottom, for a medicine, in which the entirety of liquid medicament in the vial can be completely and easily aspirated by a syringe, without need of inclination of the vial so as to aspirate the liquid medicament remaining at a corner portion of the bottom of the vial by the syringe whose front end is moved to the corner portion. [0006]
    • SUMMARY OF THE INVENTION
  • The inventors have conceived that if the needle which is penetrated into a vial through a needle-penetrable rubber closure is automatically brought to the deepest or innermost portion of the vial on the center axis thereof, it is possible to easily aspirate the whole quantity of liquid medicament in the vial into the syringe. Namely, in order to achieve the above object, a cylindrical vial having a bottom, for a medicine, in which an open end of the cylindrical vial is sealed by a needle-penetrable rubber closure through which a needle can be penetrated, the cylindrical vial including a conical bottom end provided opposite to the open end, wherein the apex of the conical bottom end is located on a central axis of the cylindrical vial at the bottommost point inside the cylindrical vial. [0007]
  • In general, a conventional cylindrical vial having a bottom is made of a resin material by blow molding. However, it is difficult to precisely form the conical bottom end by the blow molding. To solve this problem, in an embodiment, the cylindrical vial is formed using an injection molding die assembly including a core pin, the core pin being in the form of a rod having a uniform diameter and having a conical front end. Dies other than the core pin are not limited to a specific shape or structure and can be of any structure. [0008]
  • In another embodiment, the cylindrical vial is formed using an injection molding die assembly including a core pin, the core pin being in the form of a tapered rod having a conical front end and having an outer diameter gradually increasing from the conical front end toward the other end thereof. Dies other than the core pin are not limited to a specific shape or structure and can be of any structure. [0009]
  • To make it possible to aspirate the whole quantity of liquid medicament in the cylindrical vial by a needle of a syringe without inclining the cylindrical vial, the conical bottom end of the cylindrical vial preferably defines an angle in the range of 30° through 70° between the generatrix of the conical bottom end and the central axis of the cylindrical vial. If the angle is less than 30°, it is necessary to increase the length of the cylindrical vial in order to provide the same capacity as that of a conventional cylindrical vial, and there is a possibility that the needle cannot reach the deepest or innermost portion of the cylindrical vial. Furthermore, since the mass of resin of which the bottom portion of the cylindrical vial is increased, the cylindrical vial becomes heavy. If the angle exceeds 70°, no effect expected from the conical shape can be obtained. [0010]
  • According to another aspect of the present invention, a cylindrical vial for a medicine is provided, including an axial hollow portion, an open end connected to the axial hollow portion and a closed end opposite to the open end. The open end is sealed by a needle-penetrable rubber closure through which a needle can be penetrated into the cylindrical vial. The closed end includes a conical bottom end, the apex of the conical bottom end being located on a central axis of the axial hollow portion at the bottommost point inside the axial hollow portion. [0011]
  • In an embodiment, the axial hollow portion is formed using an injection molding die assembly including a core pin, the core pin being in the form of a rod having a uniform diameter and having a conical front end. [0012]
  • In another embodiment, the axial hollow portion is formed using an injection molding die assembly including a core pin, the core pin being in the form of a tapered rod having a conical front end and having an outer diameter gradually increasing from the conical front end toward the other end thereof. [0013]
  • Preferably, the conical bottom end of the cylindrical vial defines an angle in the range of 30° through 70° between the generatrix of the conical bottom end and the central axis of the axial hollow portion. [0014]
  • The present disclosure relates to subject matter contained in Japanese Patent Application No. 2000-201936 (filed on Jul. 4, 2000) which is expressly incorporated herein by reference in its entirety.[0015]
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • The invention will be discussed below in detail with reference to the accompanying drawings, in which; [0016]
  • FIG. 1 is a longitudinal sectional view of an embodiment of a vial for a medicine in which an open end is sealed by a needle stickable rubber closure, according to the present invention; [0017]
  • FIG. 2 is an enlarged view of a lower portion of FIG. 1; and, [0018]
  • FIG. 3 is a schematic sectional view of an injection molding die assembly for producing a vial for a medicine, according to the present invention.[0019]
    • DESCRIPTION OF THE PREFERRED EMBODIMENT
  • FIG. 1 shows a bottomed [0020] cylindrical vial 10 which is filled with a liquid medicament, according to an embodiment of the present invention. The cylindrical vial 10 is long and elongated and is provided with a closed end and an open end 11 which is closed by a rubber closure (needle-penetrable rubber closure) 20. The rubber closure 20 is provided on its center portion with a reduced thickness portion 21 through which a needle of a syringe can be penetrated. The rubber closure 20 is secured, in a liquid-tight fashion, to the open end 11 by a retainer (rubber closure holding member) 22.
  • The axial [0021] hollow portion 12 of the bottomed cylindrical vial 10 has a rotationally symmetrical shape with respect to the axis 10X of the cylindrical vial 10 and has a uniform diameter over the overall length thereof from the open end 11 to a conical bottom 13 thereof. The conical bottom 13 is deepest at the apex of the cone located on the axis 10X and gradually decreases the depth toward the periphery thereof. The angle α (FIG. 2) defined between the generatrix of the conical bottom 13 and the axis 10X is preferably in the range of 30° to 70°, from the viewpoint of facilitation of use, and is more preferably in the range of 40° to 60°.
  • The bottomed [0022] cylindrical vial 10 is made of a resin material by injection molding. FIG. 3 schematically shows an injection molding die assembly. The injection molding die assembly 30 is provided with a core pin (rod-like central die) 32 in the form of a rod whose diameter corresponds to the inner diameter of the axial hollow portion 12 and which has a conical front end 31 corresponding to the conical bottom 13, and a pair of right and left split dies 33 and 34 which define therebetween a molding cavity 10M for the bottomed cylindrical vial 10, together with the core pin 32. At least one of the split dies 33 and 34 is provided with a gate 35 through which a molding resin material is introduced into the molding cavity.
  • Various split structures of the [0023] split dies 30 to define the molding cavity 10M can be used, provided that the axial hollow portion 12 is formed by the core pin 32, and that the core pin 32 is provided on its front end with the conical portion 31 corresponding to the conical bottom 13.
  • The bottomed [0024] cylindrical vial 10 for a medicine, which is formed by the injection molding die assembly 30, is washed and is subject to other necessary operations. Subsequently, a liquid medicament is filled in the axial hollow portion 12 of the cylindrical vial 10. Thereafter, the needle-penetrable rubber closure 20 is attached to the open end 11 of the cylindrical vial 10 and is secured thereto by a retainer 22 to seal the open end.
  • When liquid medicament in the [0025] cylindrical vial 10 is used, a needle 40 attached to a syringe is penetrated into the cylindrical vial 10 through the thin portion 21 of the rubber closure 20. The retraction (inward movement) of a plunger in the syringe causes the liquid medicament in the cylindrical vial 10 to be aspirated into the syringe. When the needle 40 is inserted up to the innermost portion of the cylindrical vial 10, the front end of the needle 40 naturally moves to the apex of the cone of the conical bottom 13 while being guided by the conical surface. Since the liquid medicament in the cylindrical vial 10 is collected in the conical bottom 13, substantially all of the liquid medicament in the cylindrical vial 10 can be aspirated by the syringe without needing to incline the cylindrical vial 10.
  • Although the [0026] core pin 32 of the molding die assembly 30 shown in FIG. 3 has a uniform diameter, it is possible to provide the core pin 32 with a tapered peripheral surface for easy release thereof. Namely, the core pin 32 can be in the form of a slightly tapered rod whose outer diameter is gradually increased from the conical end 31 toward the other end. The taper angle should be as small as possible.
  • As may be understood from the above discussion, according to the present invention, when the liquid medicament in the cylindrical vial with a bottom is aspirated into a syringe by a needle, it is possible to easily aspirate the whole quantity of the liquid medicament without inclining the cylindrical vial. [0027]
  • Obvious changes may be made in the specific embodiments of the present invention described herein, such modifications being within the spirit and scope of the invention claimed. It is indicated that all matter contained herein is illustrative and does not limit the scope of the present invention. [0028]

Claims (8)

What is claimed is:
1. A cylindrical vial having a bottom, for a medicine, in which an open end of said cylindrical vial is sealed by a needle-penetrable rubber closure through which a needle can be penetrated, said cylindrical vial comprising:
a conical bottom end provided opposite to said open end, wherein the apex of said conical bottom end is located on a central axis of said cylindrical vial at the bottommost point inside said cylindrical vial.
2. The cylindrical vial having a bottom according to claim 1, wherein said cylindrical vial is formed using an injection molding die assembly including a core pin, said core pin being in the form of a rod having a uniform diameter and having a conical front end.
3. The cylindrical vial having a bottom according to claim 1, wherein said cylindrical vial is formed using an injection molding die assembly including a core pin, said core pin being in the form of a tapered rod having a conical front end and having an outer diameter gradually increasing from the conical front end toward the other end thereof.
4. The cylindrical vial having a bottom according to claim 1, wherein said conical bottom end of said cylindrical vial defines an angle in the range of 30° through 70° between the generatrix of said conical bottom end and the central axis of said cylindrical vial.
5. A cylindrical vial for a medicine, comprising an axial hollow portion, an open end connected to said axial hollow portion and a closed end opposite to said open end;
wherein said open end is sealed by a needle-penetrable rubber closure through which a needle can be penetrated into said cylindrical vial, and wherein said closed end comprises a conical bottom end, the apex of said conical bottom end being located on a central axis of said axial hollow portion at the bottommost point inside said axial hollow portion.
6. The cylindrical vial according to claim 5, wherein said axial hollow portion is formed using an injection molding die assembly including a core pin, said core pin being in the form of a rod having a uniform diameter and having a conical front end.
7. The cylindrical vial according to claim 5, wherein said axial hollow portion is formed using an injection molding die assembly including a core pin, said core pin being in the form of a tapered rod having a conical front end and having an outer diameter gradually increasing from the conical front end toward the other end thereof.
8. The cylindrical vial according to claim 5, wherein said conical bottom end of said cylindrical vial defines an angle in the range of 30° through 70° between the generatrix of said conical bottom end and the central axis of said axial hollow portion.
US09/881,368 2000-07-04 2001-06-14 Cylindrical vial with bottom for medicine Abandoned US20020003122A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US10/143,409 US6756008B2 (en) 2000-07-04 2002-05-09 Cylindrical vial with bottom for medicine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000201936A JP4313932B2 (en) 2000-07-04 2000-07-04 Bottomed cylindrical container for pharmaceutical products
JP2000-201936(P) 2000-07-04

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US10/143,409 Expired - Lifetime US6756008B2 (en) 2000-07-04 2002-05-09 Cylindrical vial with bottom for medicine

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EP (1) EP1170219B1 (en)
JP (1) JP4313932B2 (en)
AT (1) ATE323651T1 (en)
CA (1) CA2351767C (en)
DE (1) DE60118840T2 (en)
DK (1) DK1170219T3 (en)
ES (1) ES2262576T3 (en)

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US20030198577A1 (en) * 2002-04-19 2003-10-23 Trade Winds Direct, Inc. High recovery vial construction
US20050137533A1 (en) * 2003-12-17 2005-06-23 Masamichi Sudo Piston for a syringe and a prefilled syringe using the same
US20060054586A1 (en) * 2004-09-14 2006-03-16 Daikyo Seiko, Ltd. Container units for drugs, drug containers, and rubber closures
US20070284330A1 (en) * 2006-06-07 2007-12-13 J.G. Finneran Associates, Inc. Two-piece seal vial assembly
US11285081B2 (en) * 2017-02-17 2022-03-29 Santen Pharmaceutical Co., Ltd. Sealed preparation container and use for same
CN114906476A (en) * 2022-05-12 2022-08-16 四川先通原子医药科技有限公司 Rubber cover body, container and application thereof

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CN114789843B (en) * 2022-04-24 2022-11-22 四川先通原子医药科技有限公司 Container for radioactive particles and use thereof

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030198577A1 (en) * 2002-04-19 2003-10-23 Trade Winds Direct, Inc. High recovery vial construction
US20050137533A1 (en) * 2003-12-17 2005-06-23 Masamichi Sudo Piston for a syringe and a prefilled syringe using the same
US7927315B2 (en) * 2003-12-17 2011-04-19 Daikyo Seiko, Ltd. Piston for a syringe and a prefilled syringe using the same
US20060054586A1 (en) * 2004-09-14 2006-03-16 Daikyo Seiko, Ltd. Container units for drugs, drug containers, and rubber closures
US7934613B2 (en) 2004-09-14 2011-05-03 Daikyo Seiko, Ltd. Container units for drugs, drug containers, and rubber closures
US20070284330A1 (en) * 2006-06-07 2007-12-13 J.G. Finneran Associates, Inc. Two-piece seal vial assembly
US7934614B2 (en) * 2006-06-07 2011-05-03 J. G. Finneran Associates, Inc. Two-piece seal vial assembly
US11285081B2 (en) * 2017-02-17 2022-03-29 Santen Pharmaceutical Co., Ltd. Sealed preparation container and use for same
CN114906476A (en) * 2022-05-12 2022-08-16 四川先通原子医药科技有限公司 Rubber cover body, container and application thereof

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JP4313932B2 (en) 2009-08-12
EP1170219B1 (en) 2006-04-19
JP2002017816A (en) 2002-01-22
ATE323651T1 (en) 2006-05-15
DK1170219T3 (en) 2006-08-14
US20020128627A1 (en) 2002-09-12
CA2351767C (en) 2010-05-04
US6756008B2 (en) 2004-06-29
ES2262576T3 (en) 2006-12-01
EP1170219A1 (en) 2002-01-09
DE60118840T2 (en) 2006-12-28
CA2351767A1 (en) 2002-01-04
DE60118840D1 (en) 2006-05-24

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