US20010018519A1 - Preparation of opiates - Google Patents

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Publication number
US20010018519A1
US20010018519A1 US09/835,525 US83552501A US2001018519A1 US 20010018519 A1 US20010018519 A1 US 20010018519A1 US 83552501 A US83552501 A US 83552501A US 2001018519 A1 US2001018519 A1 US 2001018519A1
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Prior art keywords
oxidation
lower alkyl
codeine
process according
mno
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US09/835,525
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Alice Sebastian
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Johnson Matthey PLC
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Johnson Matthey PLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Definitions

  • the present invention relates to a novel process for the preparation of codeinone and analogues thereof.
  • Codeinone is a key intermediate for the synthesis of many morphinoid compounds. It is therefore desirable for a simple, straightforward and cost effective process for its preparation.
  • codeinone was obtained from thebaine by treating it with dry HBr in CH 2 Cl 2 at ⁇ 25°, followed by hydrolysis with water and dehydrobrominating with cold NaOH (Vesely, Z., Hodkova, J. and Trojanek J., Cesk. Farm. 1986, 35, 222-6).
  • thebaine was converted to a mixture of codeinone and neopinone in aqueous HCO 2 H containing Hg(OAc) 2 (U.S. Pat. No. 4,277,604).
  • thebaine is very expensive and does not occur naturally in a high yield; therefore the preparation of codeinone from thebaine is not an attractive method.
  • An alternative process for the preparation of codeinone is the direct oxidation of codeine using variety of reagents, such as silver carbonate (Rapoport, H. and Reist, N. H., J. Am. Chem. Soc. 1955, 27, 490-491) and Jones' reagent (Findlay, J .W. A., Butz, R. F. and Jones, E. C., Clin. Chem. 1981, 77, 1524-1535); however, these reagents only gave codeinone in poor yield. Only Oppenauer oxidation (U.S. Pat. No. 2,654,756) has given codeinone in reasonably good yield and high purity. All these methods have their drawbacks, however. Oxidation with silver carbonate is not preferred due to its cost and incomplete reaction, whereas in the case of Jones's oxidation and Oppenauer oxidation the isolation of the product is difficult and complex.
  • reagents such as silver carbonate (Rapoport, H. and Reist, N. H., J. Am.
  • the object of the present invention is to provide a simple process for the preparation of codeinone and analogues thereof, and which provides the desired product in high yield and purity.
  • the present inventors have found that if oxidation of codeine or a salt thereof, for example the phosphate salt, is carried out at acidic pH, a high yield of codeinone is obtained which is not obtainable by any of the methods heretofore disclosed.
  • the present invention provides a novel process for the preparation of a compound of formula (I)
  • R 1 is lower alkyl or a group
  • R 4 is lower alkyl, lower alkyl substituted by halogen or phenyl, phenyl or substituted phenyl;
  • R 2 is lower alkyl, allyl or lower alkyl substituted by cycloalkyl
  • each of R 1 and R 2 may be the same or different and each is lower alkyl, for example C 1-6 alkyl, such as C 1-4 alkyl, for example methyl or ethyl and preferably ethyl.
  • the salt is the phosphate salt (H 3 PO 4 ).
  • the oxidation is carried out at a pH of from 0.1 ⁇ pH>7; preferably, the oxidation is carried out at a pH of from 0.8 ⁇ pH>4.5; most preferably the oxidation is carried out at a pH of from 0.8 to 1.2.
  • the solvent may be any solvent suitable for use in such an oxidation reaction.
  • Acetone was found to be the most suitable solvent for giving the desired product in high yield and high purity.
  • Other solvents were also found to be particularly useful and were preferred in the order: acetone >THF>IPA>CH 3 CN >NMP.
  • the solvent is used as a 50:50 (v/v) solvent/water mixture.
  • the oxidation reagent is suitably manganese dioxide, such as activated manganese dioxide or ⁇ -manganese dioxide, preferably ⁇ -manganese dioxide.
  • the oxidation reagent is present in an amount of at least 3 equivalents or more with respect to the compound of formula (I).
  • a solution of codeine or codeine phosphate was dissolved in the appropriate solvent system and a specified volume of hydrochloric acid of varying concentration was added.
  • Manganese dioxide (either freshly prepared ⁇ -manganese dioxide or activated manganese dioxide from Aldrich) was added and the reaction mixture was stirred at ambient temperature for 1.5 to 4 hours. The progress of the reaction was monitored by HPLC. The reaction mixture was filtered through a celite pad, washed with additional solvent or water, and neutralised with ammonium hydroxide. The product was extracted with methylene chloride (3 ⁇ 150 ml) and the combined extracts washed with water and dried over anhydrous sodium sulphate. The organic layer was then evaporated to yield codeinone.

Abstract

A novel process for the preparation of codeinone and analogues thereof comprising the oxidation of a compound of formula,
Figure US20010018519A1-20010830-C00001
or a salt thereof, wherein R1 is lower alkyl or a group
Figure US20010018519A1-20010830-C00002
wherein R4 is lower alkyl, lower alkyl substituted by halogen or phenyl, phenyl or substituted phenyl; and R2 is lower alkyl, allyl or lower alkyl substituted by cycloalkyl, characterised in that the oxidation is carried out in an acidic environment is disclosed.

Description

  • The present invention relates to a novel process for the preparation of codeinone and analogues thereof. [0001]
  • Codeinone is a key intermediate for the synthesis of many morphinoid compounds. It is therefore desirable for a simple, straightforward and cost effective process for its preparation. [0002]
  • In earlier works, codeinone was obtained from thebaine by treating it with dry HBr in CH[0003] 2Cl2 at −25°, followed by hydrolysis with water and dehydrobrominating with cold NaOH (Vesely, Z., Hodkova, J. and Trojanek J., Cesk. Farm. 1986, 35, 222-6). In another method, thebaine was converted to a mixture of codeinone and neopinone in aqueous HCO2H containing Hg(OAc)2 (U.S. Pat. No. 4,277,604). However, thebaine is very expensive and does not occur naturally in a high yield; therefore the preparation of codeinone from thebaine is not an attractive method.
  • An alternative process for the preparation of codeinone is the direct oxidation of codeine using variety of reagents, such as silver carbonate (Rapoport, H. and Reist, N. H., J. Am. Chem. Soc. 1955, 27, 490-491) and Jones' reagent (Findlay, J .W. A., Butz, R. F. and Jones, E. C., Clin. Chem. 1981, 77, 1524-1535); however, these reagents only gave codeinone in poor yield. Only Oppenauer oxidation (U.S. Pat. No. 2,654,756) has given codeinone in reasonably good yield and high purity. All these methods have their drawbacks, however. Oxidation with silver carbonate is not preferred due to its cost and incomplete reaction, whereas in the case of Jones's oxidation and Oppenauer oxidation the isolation of the product is difficult and complex. [0004]
  • The direct oxidation of codeine with active manganese dioxide (Ninan, A. and Sainsbury, M., Tetrahedron, 1992, 48, 6709) and γ-manganese dioxide (Highet, R. J. and Wildman, W. C., J. Am. Chem. Soc., 1955, 77, 4399) has also been reported. However, in both cases pure codeinone was obtained in only low yield due to the formation of 14β-hydroxycodeinone and low conversion. [0005]
  • The object of the present invention is to provide a simple process for the preparation of codeinone and analogues thereof, and which provides the desired product in high yield and purity. The present inventors have found that if oxidation of codeine or a salt thereof, for example the phosphate salt, is carried out at acidic pH, a high yield of codeinone is obtained which is not obtainable by any of the methods heretofore disclosed. [0006]
  • Accordingly, the present invention provides a novel process for the preparation of a compound of formula (I) [0007]
    Figure US20010018519A1-20010830-C00003
  • wherein R[0008] 1 is lower alkyl or a group
    Figure US20010018519A1-20010830-C00004
  • wherein R[0009] 4 is lower alkyl, lower alkyl substituted by halogen or phenyl, phenyl or substituted phenyl; and
  • R[0010] 2 is lower alkyl, allyl or lower alkyl substituted by cycloalkyl;
  • comprising the oxidation of a compound of formula (II), [0011]
    Figure US20010018519A1-20010830-C00005
  • or a salt thereof, wherein R[0012] 1 and R2 are as hereinbefore defined; characterised in that the oxidation is carried out in an acidic environment.
  • Preferably, each of R[0013] 1 and R2 may be the same or different and each is lower alkyl, for example C1-6 alkyl, such as C1-4 alkyl, for example methyl or ethyl and preferably ethyl.
  • When the compound of formula (II) is present as a salt, preferably the salt is the phosphate salt (H[0014] 3PO4).
  • Suitably the oxidation is carried out at a pH of from 0.1<pH>7; preferably, the oxidation is carried out at a pH of from 0.8<pH>4.5; most preferably the oxidation is carried out at a pH of from 0.8 to 1.2. [0015]
  • The solvent may be any solvent suitable for use in such an oxidation reaction. Acetone was found to be the most suitable solvent for giving the desired product in high yield and high purity. Other solvents were also found to be particularly useful and were preferred in the order: acetone >THF>IPA>CH[0016] 3CN >NMP. Preferably, the solvent is used as a 50:50 (v/v) solvent/water mixture.
  • The oxidation reagent is suitably manganese dioxide, such as activated manganese dioxide or γ-manganese dioxide, preferably γ-manganese dioxide. Suitably, the oxidation reagent is present in an amount of at least 3 equivalents or more with respect to the compound of formula (I). [0017]
  • The invention will now be further described by way of example only. [0018]
    • GENERAL PROCEDURE FOR THE PREPARATION OF CODEINONE FROM CODEINE PHOSPHATE OR CODEINE
  • A solution of codeine or codeine phosphate was dissolved in the appropriate solvent system and a specified volume of hydrochloric acid of varying concentration was added. Manganese dioxide (either freshly prepared γ-manganese dioxide or activated manganese dioxide from Aldrich) was added and the reaction mixture was stirred at ambient temperature for 1.5 to 4 hours. The progress of the reaction was monitored by HPLC. The reaction mixture was filtered through a celite pad, washed with additional solvent or water, and neutralised with ammonium hydroxide. The product was extracted with methylene chloride (3×150 ml) and the combined extracts washed with water and dried over anhydrous sodium sulphate. The organic layer was then evaporated to yield codeinone. [0019]
  • In all the experiments the reaction was followed by HPLC and the retention time of the product was compared with that of the standard. In some cases the crude product was quantitated to obtain the purity. The HPLC analysis was done on a Shimadzu system. The column used was Phenomenex's Prodigy 5μ ODS (3) 100°Å, 250×4.6 mm. The method was isocratic. The mobile phase was: water (1450 ml)+ acetonitrile (550 ml)+Et[0020] 3N (2 ml)+1.73 g of 1-octanesulphonate, sodium salt+pH 3.5 (adjusted with 85% phosphoric acid). In the cases where the product was isolated, it was also characterised by comparing its 1H NMR with that of the standard: 1H NMR (CDCl3)δ1.85-1.92(1H,m,15α),2.05-2.15(1H,m,16α),2.27-2.4(2H,m,1562,10α), 2.45(3H,s,N-CH3),2.58-2.62(1H,m,H16β)3.07-3.14(1H,d,H10β),3.19-3.21(1H,d, H9α),3.39-3.44(1H,m,H14),3.84(3H,s,OCH3),4.70(1H,s,H5β),6.05-6.11(1H,dd, H8),6.59-6.70(3H,m,H1,H2,H7).
  • The following examples were carried out using the starting material and reagents indicated. [0021]
    Starting Solvent Purity
    Example Material System Acid Oxidant Yield (HPLC
    No (g) (ml) (ml) (g) pH (%) area %)
    1 Codeine IPA (14) 6N HCl γ-MnO2 1.62 94 ˜95
    (0.5) H2O (14) (0.5) (1.6)
    2 Codeine IPA (22) — γ-MnO2 4.5 NA ˜34
    phosphate H2O (22) (3.2)
    (1)
    3 Codeine IPA (14) 6N HCl γ-MnO2 1.6 80 91.8
    phosphate H2O (14) (0.5) (1.6)
    (0.5)
    4 Codeine IPA (40) 6N HCl γ-MnO2 1.44 NA 60.3
    (2) H2O (40) (2) (4)
    5 Codeine IPA (40) 6N HCl γ-MnO2 1.3 86 ˜91.8
    (2) H2O (40) (3) (7)
    6 Codeine IPA (10) 6N HCl γ-MnO2 0.73 75 82
    (0.5) H2O (10) (2) (1.5)
    7 Codeine IPA (10) 6N HCl γ-MnO2 1.16 92 ˜97
    (0.5) H2O (10) (1) (1.5)
    8 Codeine IPA (10) 6N HCl γ-MnO2 1.41 95 ˜95
    (0.5) H2O (10) (0.75) (1.5)
    9 Codeine CH3CN (10) 6N HCl γ-MnO2 0.9 89.7 ˜93
    (0.5) H2O (10) (0.75) (1.5)
    10 Codeine IPA (10) 6N HCl γ-MnO2 <0.1 50.4 ˜71
    (0.5) H2O (10) (4) (1.5)
    11 Codeine Acetone (10) 6N HCl γ-MnO2 0.92 95.2 94
    (0.5) H2O (10) (0.75) (1.5)
    12 Codeine THF (10) 6N HCl γ-MnO2 1.21 89 93
    (0.5) H2O (10) (0.75) (1.5)
    13 Codeine NMP (20) — γ-MnO2 — NA ˜21.6
    (0.5)
    14 Codeine NMP (10) 6N HCl γ-MnO2 1.45 NA ˜90
    (0.5) H2O (10) (1)
    15 Codeine Acetone (200) 6N HCl γ-MnO2 1.02 83.5 95.5
    (11.45) H2O (200) (16) (36)
    16 Codeine Acetone (10) 6N HCl Activated 0.87 NA ˜45
    (0.5) H2O (10) (0.75) 85% MnO2
    (Aldrich)
    17 Codeine IPA (25) — γ-MnO2(3) — NA ˜41
    (1) CH2Cl2 (25)
    • Preparation of γ-Manganese Dioxide
  • Manganese (II) sulphate monohydrate (140 g) was dissolved in 2.66 liters of water and heated to 60° C. Potassium permanganate (97.3 g) in 1.85 liter of water was added over a period of 15 minutes and stirred at 60° C. for 1 hour, until manganese dioxide precipitated out. The reaction mixture was filtered and the residue was washed with deionised water until no sulphate ion was present. The solid was dried under suction for 2 hours followed by drying at 70° C. under vacuum to a constant weight (˜8 days) to give 115 g of a dark brown powder. [0022]

Claims (9)

1. A process for the preparation of a compound of formula (I)
Figure US20010018519A1-20010830-C00006
wherein R1 is lower alkyl or a group
Figure US20010018519A1-20010830-C00007
wherein R4 is lower alkyl, lower alkyl substituted by halogen or phenyl. phenyl or substituted phenyl; and
R2 is lower alkyl, allyl or lower alkyl substituted by cycloalkyl;
comprising the oxidation of a compound of formula (II),
Figure US20010018519A1-20010830-C00008
or a salt thereof, wherein R1 and R2 are as hereinbefore defined, characterised in that the oxidation is carried out in an acidic environment:
2. A process according to
claim 1
 wherein each of R1 and R2 may be the same or different and each is lower alkyl.
3. A process according to
claim 2
 wherein each of R1 and R2 may be the same or different and is methyl or ethyl.
4. A process according to
claim 3
 wherein R1 and R2 are both ethyl.
5. A process according to any one of
claims 1
 to
4
 wherein when the compound of formula (II) is present as a salt, the salt is the phosphate salt.
6. A process according to any one of
claims 1
 to
5
 wherein the oxidation is carried out at a pH of between 0.1 and 7.
7. A process according to
claim 6
 wherein the oxidation is carried out at a pH of between 0.8 and 4.5.
8. A process according to
claim 7
 wherein the oxidation is carried out at a pH of from 0.8 to 1.2.
9. A process according to any one of
claims 1
 to
8
 wherein the oxidation reagent is manganese dioxide.
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050124811A1 (en) * 2002-11-11 2005-06-09 Wang Peter X. Method for the catalytic production of hydrocodone and hydromorphone
US20060074239A1 (en) * 2002-11-11 2006-04-06 Wang Peter X Method for the catalytic production of hydrocodone and hydromorphone
US20060155130A1 (en) * 2002-11-11 2006-07-13 Mallinckrodt Inc. Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof
US20070045101A1 (en) * 2005-07-06 2007-03-01 Rochester Institute Of Technology Self-regenerating particulate trap systems for emissions and methods thereof

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AU2001281599B2 (en) * 2000-08-25 2007-07-12 Glaxo Wellcome Australia Ltd Chemical methods
AUPQ968300A0 (en) * 2000-08-25 2000-09-21 Glaxo Wellcome Australia Ltd Chemical methods
ATE407136T1 (en) * 2002-02-28 2008-09-15 Mallinckrodt Inc METHOD AND SYSTEM FOR THE SEPARATION AND PURIFICATION OF AT LEAST ONE NARCOTIC ALKALOID USING PREPARATIVE REVERSE PHASE CHROMATOGRAPHY
US6864370B1 (en) 2003-06-05 2005-03-08 Zhaiwei Lin Process for manufacturing oxycodone
TW201509943A (en) 2004-03-30 2015-03-16 Euro Celtique Sa Oxycodone hydrochloride composition, pharmaceutical dosage form, sustained release oral dosage form and pharmaceutically acceptable package having less than 25 PPM 14-hydroxycodeinone
US6946556B1 (en) * 2004-05-21 2005-09-20 Acura Pharmaceuticals, Inc. Preparation of opioid analgesics by a one-pot process
TR2021022252A2 (en) * 2021-12-31 2022-01-21 Toprak Mahsulleri Ofisi Genel Mueduerluegue A NEW METHOD FOR THE PRODUCTION OF CODEINE CAMPHOSULPHONATE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE408870C (en) * 1923-09-11 1925-01-24 Merck Chem Fab E Procedure for the representation of Kodeienon
US2654756A (en) * 1949-10-20 1953-10-06 Mallinckrodt Chemical Works Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
US4277604A (en) * 1980-01-25 1981-07-07 The United States Of America As Represented By The Department Of Health And Human Services Facile synthesis of codeine precursors from thebaine

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050124811A1 (en) * 2002-11-11 2005-06-09 Wang Peter X. Method for the catalytic production of hydrocodone and hydromorphone
US20060074239A1 (en) * 2002-11-11 2006-04-06 Wang Peter X Method for the catalytic production of hydrocodone and hydromorphone
US20060155130A1 (en) * 2002-11-11 2006-07-13 Mallinckrodt Inc. Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof
US7321038B2 (en) 2002-11-11 2008-01-22 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
US7323565B2 (en) 2002-11-11 2008-01-29 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
US7399858B2 (en) 2002-11-11 2008-07-15 Mallinckrodt Inc. Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof
US20070045101A1 (en) * 2005-07-06 2007-03-01 Rochester Institute Of Technology Self-regenerating particulate trap systems for emissions and methods thereof
US8115373B2 (en) 2005-07-06 2012-02-14 Rochester Institute Of Technology Self-regenerating particulate trap systems for emissions and methods thereof
US8580087B2 (en) 2005-07-06 2013-11-12 Rochester Institute Of Technology Self-regenerating particulate trap systems for emissions and methods thereof
US8581480B2 (en) 2005-07-06 2013-11-12 Rochester Institute Of Technology Self-regenerating particulate trap systems for emissions and methods thereof
US8991153B2 (en) 2005-07-06 2015-03-31 Rochester Institute Of Technology Self-regenerating particulate trap systems for emissions and methods thereof

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EP0943617A1 (en) 1999-09-22
EP0943617B1 (en) 2003-08-06
JPH11292866A (en) 1999-10-26
ES2205711T3 (en) 2004-05-01
DE69910101T2 (en) 2004-05-13
DE69910101D1 (en) 2003-09-11
ATE246688T1 (en) 2003-08-15
US6235906B1 (en) 2001-05-22

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