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Device for inserting medicaments into the body by iontophoresis

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Publication number
US1967927A
US1967927A US56131231A US1967927A US 1967927 A US1967927 A US 1967927A US 56131231 A US56131231 A US 56131231A US 1967927 A US1967927 A US 1967927A
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US
Grant status
Grant
Patent type
Prior art keywords
lining
electrode
medicament
medicaments
iontophoresis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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Inventor
Deutsch Desider
Original Assignee
Firm Schering Kahlbaum Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448Drug reservoir

Description

Patented July 24, 1934 UNITED STATES DEVICE FOR INSERTING MEDICAMENTS INTO THE BODY BY IONTOPHORESIS Desider Deutsch, Budapest, Hungary, assignor to the firm Schering-Kahlbaum Aktiengesellschaft, Berlin, Germany No Drawing. Application September 4, 1931, Serial No. 561,312. In Germany June 17, 1931 3 Claims.

My invention relates to a device for inserting medicaments into the human or animal body by means of iontophoresis It is known to insert medicaments into the body by iontophoresis. To this end the medicament is put on the skin in fluid state and covered with an electrode connected to one pole of a direct current source while the other pole of said current source is connected to another electrode being in contact with any other part of the body. Thus the current flowing through the electrode and the medicament inserts the latter through the skin into the body. Instead of putting the medicament directly upon the skin it is also known to impregnate a pad of cotton-wool with the medicament and to lay this pad under the one electrode upon the skin. Both methods have several disadvantages. Owing to the poisonous effect of most medicaments if taken in greater quantities or stronger concentration than allowed, the physician must not give them into the hands of the patient but has to perform the iontophoresis himself. That is even true with the treatment of frequently appearing pains wanting repeated iontophoresis like rheumatism, so that the treatment is becoming very dear in spite of its simplicity and of the cheapness of the medicaments.

Moreover the known methods are very unthrifty even if performed by physicians, because usually there is put much more of the medicament upon the cotton-wool than necessary for one treatment and the surplus is getting lost since the same pad of cotton-wool can not be used another time. Besides it often happens that the patient gets burnt by the electric current if the electrode slides off from the wool-cotton and thus comes into direct contact with the skin.

One object of my invention is to provide means for performing the iontophoresis which can be used by everybody without danger of poisoning by the poisonous medicaments necessary therefor.

Another object is to provide a device for the said purpose by which the waste of medicaments is avoided. Another object is to prevent burning of the skin by the current.

My invention consists in a lining for the active electrode for the iontophoresis, said lining consisting of a material being impregnated with the necessary quantity of the medicament. This impregnated lining which may consist of filteringpaper, blotting-paper, textile fabric or the like can be given into the hand of the patient without scruple as wrong use of it is impossible so that the patient is thus enabled to cure his pains, for

example his rheumatism, himself. As the quantity of the medicament in the lining can be adjusted carefully there is no waste and each piece of the lining contains only as much of the medicament as necessary for one treatment. It is advantageous to mix the medicament with a disinfectant like thymol in order to prevent any decomposition of the medicament when storing for longer time. If the lining consists of the above named materials like paper or textile the water contained in the medicament will evaporate after the impregnation and the lining has to be moistened before use so as to make it conductive for the current. This is not necessary if the lining consists of hygroscopic material like hectograph-paste as in this case the lining remains damp permanently.

It is particularly advantageous to combine the lining with the electrode by providing it with a metallic covering serving as electrode. This covering may consist of a foil fastened to the lining or be produced on the lining by galvanoplastic depositing or by squirting. This combination of the lining with the electrode renders the performance of the iontophoresis very simple and easy, and makes it impossible to burn the patient since the electrode can never come into direct contact with the skin.

Having now particularly described and ascertained the nature of my said invention and in what manner the same is to be performed, I declare that what I claim is:

1. As an article of manufacture, for use in a device for inserting medicaments into the human or animal body by iontophoresis, a lining for the active electrode, said lining being impregnated with a quantity of the medicament substantially exactly sufiicient for a single treatment, said lining being substantially free of water capable of evaporating therefrom.

2. As an article of manufacture, for use in a device for inserting medicaments into the human or animal body by iontophoresis, a lining for the active electrode, said lining being impregnated with a quantity of the medicament substantially exactly suflicient for a single treatment, and a thin flexible metallic covering secured to said lining and constituting the active electrode.

3. As an article of manufacture, for use in a device for inserting medicaments into the human thin flexible metallic covering secured to said lining and constituting the active electrode, said metallic covering comprising a galvanoplastic deposit.

DESIDER DEUTSCH.

US1967927A 1931-06-18 1931-09-04 Device for inserting medicaments into the body by iontophoresis Expired - Lifetime US1967927A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE1931D0061358 DE603705C (en) 1931-06-18 1931-06-18 Electrode for the introduction of medicaments into the body by iontophoresis

Publications (1)

Publication Number Publication Date
US1967927A true US1967927A (en) 1934-07-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
US1967927A Expired - Lifetime US1967927A (en) 1931-06-18 1931-09-04 Device for inserting medicaments into the body by iontophoresis

Country Status (7)

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US (1) US1967927A (en)
BE (1) BE382242A (en)
DE (1) DE603705C (en)
ES (1) ES127011A1 (en)
FR (1) FR725942A (en)
GB (1) GB377481A (en)
NL (1) NL32493C (en)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2784715A (en) * 1953-03-25 1957-03-12 Kestler Otto Colman Cataphoresis unit
DE3304246A1 (en) * 1982-02-09 1983-08-18 Richter Gedeon Vegyeszet Iontophoresis between insert, contacting solution and using an microtubules inhibitor for the treatment of chronic pain syndromes
US4405311A (en) * 1980-12-08 1983-09-20 Greatbatch Enterprises, Inc. Method and apparatus for direct electrical injection of gold ions into tissue such as bone
US4767401A (en) * 1975-04-22 1988-08-30 Maurice Seiderman Iontophoretic administration of ionizable or polar medicaments to a mammalian body
US5415629A (en) * 1993-09-15 1995-05-16 Henley; Julian L. Programmable apparatus for the transdermal delivery of drugs and method
WO1997047353A1 (en) * 1996-06-13 1997-12-18 Novagent Oy Composition and system for iontophoretic transdermal delivery of drugs
US6254883B1 (en) 1996-01-30 2001-07-03 Novagent Oy Composition for transdermal delivery of drugs
US20020142340A1 (en) * 1986-04-18 2002-10-03 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US20030028170A1 (en) * 1998-08-31 2003-02-06 Birch Point Medical, Inc. Controlled dosage drug delivery
US20030199808A1 (en) * 1999-03-12 2003-10-23 Biophoretic Therapeutic Systems, Llc. Systems and methods for electrokinetic delivery of a substance
US20040039328A1 (en) * 1998-09-15 2004-02-26 Biophoretic Therapeutic Systems, Llc Iontophoretic drug delivery electrodes and method
US6735470B2 (en) 2000-05-31 2004-05-11 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US20040111051A1 (en) * 2000-03-10 2004-06-10 Biophoretic Therapeutic Systems, Llc. Electrokinetic delivery system for self-administration of medicaments and methods therefor
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2132565B1 (en) * 1971-04-09 1975-10-31 Bergerioux Madeleine

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2784715A (en) * 1953-03-25 1957-03-12 Kestler Otto Colman Cataphoresis unit
US4767401A (en) * 1975-04-22 1988-08-30 Maurice Seiderman Iontophoretic administration of ionizable or polar medicaments to a mammalian body
US4405311A (en) * 1980-12-08 1983-09-20 Greatbatch Enterprises, Inc. Method and apparatus for direct electrical injection of gold ions into tissue such as bone
US4602909A (en) * 1982-02-09 1986-07-29 Richter Gedeon Vegyeszeti Gyar Rt Iontophoresis intermediary material and contact solution for the treatment of chronic pain syndromes
DE3304246A1 (en) * 1982-02-09 1983-08-18 Richter Gedeon Vegyeszet Iontophoresis between insert, contacting solution and using an microtubules inhibitor for the treatment of chronic pain syndromes
US7008798B2 (en) 1986-04-18 2006-03-07 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US6989275B2 (en) 1986-04-18 2006-01-24 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US20020142340A1 (en) * 1986-04-18 2002-10-03 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5415629A (en) * 1993-09-15 1995-05-16 Henley; Julian L. Programmable apparatus for the transdermal delivery of drugs and method
US6254883B1 (en) 1996-01-30 2001-07-03 Novagent Oy Composition for transdermal delivery of drugs
WO1997047353A1 (en) * 1996-06-13 1997-12-18 Novagent Oy Composition and system for iontophoretic transdermal delivery of drugs
US20030028170A1 (en) * 1998-08-31 2003-02-06 Birch Point Medical, Inc. Controlled dosage drug delivery
US7031768B2 (en) 1998-08-31 2006-04-18 Birch Point Medical, Inc. Controlled dosage drug delivery
US6895271B2 (en) 1998-09-15 2005-05-17 Biophoretic Therapeutic Systems, Llc Iontophoretic drug delivery electrodes and method
US20040039328A1 (en) * 1998-09-15 2004-02-26 Biophoretic Therapeutic Systems, Llc Iontophoretic drug delivery electrodes and method
US7127285B2 (en) 1999-03-12 2006-10-24 Transport Pharmaceuticals Inc. Systems and methods for electrokinetic delivery of a substance
US8328788B2 (en) 1999-03-12 2012-12-11 Nitric Biotherapeutics, Inc. Methods and systems for electrokinetic delivery of a substance
US20030199808A1 (en) * 1999-03-12 2003-10-23 Biophoretic Therapeutic Systems, Llc. Systems and methods for electrokinetic delivery of a substance
US20040111051A1 (en) * 2000-03-10 2004-06-10 Biophoretic Therapeutic Systems, Llc. Electrokinetic delivery system for self-administration of medicaments and methods therefor
US8352024B2 (en) 2000-03-10 2013-01-08 Nitric Biotherapeutics, Inc. Electrokinetic delivery system for self-administration of medicaments and methods therefor
US7016724B2 (en) 2000-03-10 2006-03-21 Transport Pharmaceuticals, Inc. Electrokinetic delivery system for self-administration of medicaments and methods therefor
US6792306B2 (en) 2000-03-10 2004-09-14 Biophoretic Therapeutic Systems, Llc Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
US20040176737A1 (en) * 2000-05-31 2004-09-09 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US7069073B2 (en) 2000-05-31 2006-06-27 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US20050182351A1 (en) * 2000-05-31 2005-08-18 Biophoretic Therapeutic Systems Llc Electrokinetic delivery of medicaments
US6735470B2 (en) 2000-05-31 2004-05-11 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same

Also Published As

Publication number Publication date Type
FR725942A (en) 1932-05-19 grant
BE382242A (en) 1931-09-30 grant
DE603705C (en) 1934-10-08 grant
ES127011A1 (en) 1932-07-16 application
NL32493C (en) 1934-04-16 grant
GB377481A (en) 1932-07-28 application

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