US1650333A - Process of converting medicaments, antiseptic agents and cauterization means into a stable and readily dosable form - Google Patents

Abstract

232,906. Institut Sero-Therapique et Vaccinal Suisse. April 28, 1924, [Convention date]. Void [Published under Sect. 91 of the Act]. Medicines for internal use; medicaments for external application; dispensing; special shapes and forms, putting up in.-Medicinal. antiseptic, and cauterizing substances, such for instance as those used in dentistry for destroying nerves, are suspended uniformly in a gelatinous substance which is caused to set, dried, and formed into tablets, balls, &c. each containing a known dose of the active material. Examples of suitable media are gelatine, agar-agar, and cellulose. Active substances specified are arsenious anhydride, cobalt oxide, and arsenites formed within the jellies by reaction between arsenious anhydride and oxides, hydroxides, or salts of alkaline earths or noble or heavy metals.

Description

agents and other medicaments,

Patented Nov. 22, 1927.

UNITED STATES-PATENT OFFICE.

ARON EoKMANmor iiERN-WABERN, SWITZERLAND, ASSIGNOR a & IMPFINSTIT'UT BERN, or 13mm,- SWITZERLAND,-A SWISS PROCESS OF CONVERTING MEDICAMENTS, .ANTISEPTIG AGENTS AND CAUTERIZATION CORPORATION.

MEANS INTO 'A STABLE AND READILY DOSABLE FORM. I

I No Drawing. Application filed May 27, 1924, Serial No. 716,277, and in mice A ru 28 1924 My invention has for its object to convert therapeutically valuable substances, particularly those which are difiicultly soluble or insoluble and are used as medicaments, antiseptic agents or cauterization means, into a stable and readily dosable form, without the said substances sufiering a chemical change.

As is well known it is not easy, but even frequently impossible, correctly to dose certain antiseptic agents and cauterization means used in dentistry for killing the nerves of teeth. A particularly important practical case is the use of arsenic trioxide as a r cauterization agent. .Heretofore the dentist has had to put a wad of cotton wool into the arsenic trioxide and then insert the wad into the tooth irrespective of whether too much or too little adhered to the wad; When the correct dose was exceeded, undesirable or even dangerous results, for example necrosis, were very frequently the consequence. These drawbacks which, as mentioned above, occur also with antiseptic articularly those consisting of difficultly so uble or insoluble substances, are obviated by the present invention.

The process forming the subject-matter of the present invention comprises the steps of uniformly distributing the medicaments, antiseptic agents and cauterization means, irrespective of their solubility, in jellies of any suitable kind, and then drying the jelly.

It is well known that jellies, which are semi-solid systems of a collodial nature, behave almost like pure aqueous solutions as regards chemical compounds capable of diifusion, that is to say, under given conditions the chemical compounds enveloped in the jelly act by diifusion.

Example.

10 grammes of arsenic trioxide are put into 150 com. water, are heated and filtered. The filtrate is slowly mixed with a solution containing a high percentage of gelatine,

and then this mixture is evaporated on they desired shapes, such as tablets, cubes, prisms,

balls and so on, whereof each contains an exactly determined dose of arsenic trioxide.

In an exactly analogous manner, the socalled cobalt filling, which is also used in dentistry for cauterizing purposes, can be made. A weighed quantity of bits of cobalt 1S intimately mixed with a highly concentrated gelatine solution, this being facilitated by adding some heated water, and the mixture is heated on the water bath and allowed to congeal. After having been completely dried in vacuo, a homogeneous mass is obtained which can be closed after being weighed.

One may also practice the process by suspending, as described above, two difierent substances capable of chemically reacting one on the other, independently of each other in a. highly concentrated gelatine solution, and then mixing together the stillliquid or semi-liquid masses and drying the mixture, Thus, for example, one can mix the above described jelly containing arsenic trioxide with a jelly containing an oxide, hydroxide e. g. magnesium oxide, ferric hydroxide, or salt of the alkaline-earth, or precious, or heavy metals, which acts as an antidote .of the arsenic trioxide. If two such jellies are placed on the pulp of a tooth with the jelly containing the arsenic trioxide at the bottom, the arsenic trioxide will first diffuse through the jelly and act on the pulp. Any excess of arsenic trioxide is made harmless by the subsequent diffusion of the antidote referred to.

In each case one may use as jelly any convenient and suitable substance, such as, for example, gelatine, agaragar, cellulose and the like.

The above mentioned examples relate solely to cauterization agents. It is, however, to be distinctly understood that the process can be employed just as well with substances serving as antiseptic means and medicaments.

I claim:

1. The process of producing a means for killing the nerve of a tooth, which comprises mixing suitable substances irrespective of their solubility in a Well-known manner with a suitable jelly, uniformly distributing the substances therein, then drying the jelly, and then molding it into tablets or the like so TO SGHWEIZ. SERUM- cauterizing agent and the other an antidete of the same, independently of each other in suita le jellies and uniformly distributing 1 said'substances in said jellies, then combining the jellies with each other, drying the same and finally molding the combined substances into tablets or the like, so that each tablet contains a predetermined, definite and 15 known quantity-0f the active substances. 1

ARON ECKMANN,