US1498666A - Tablet - Google Patents
Tablet Download PDFInfo
- Publication number
- US1498666A US1498666A US583028A US58302822A US1498666A US 1498666 A US1498666 A US 1498666A US 583028 A US583028 A US 583028A US 58302822 A US58302822 A US 58302822A US 1498666 A US1498666 A US 1498666A
- Authority
- US
- United States
- Prior art keywords
- tablet
- tablets
- new york
- friable
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Definitions
- My invention relates to tablets and refers particularly to medicinal tablets and processes for producing the same.
- One object of my invention is a non-friable tablet.
- Another object of my invention is a tabletcomprising a friable material enclosed Within a liquid pervious cover of such structural strength as topreserve the tablet in a nondisintegrable condition under normal conditions.
- any covering, orcoating, for medicinal tablets of this character must be of such material or in such physical condition as to allow of the ready and positive breaking down of the tablet when taken internally, in order to obtain the full efliciency of the contained medicinal products.
- materials having the above described properties may be covered with a' coating of certain waxes and similar products with the formation of a product which is pervious to aqueous liquid, resulting in a breaking down of the tablet forefiiciency of physiological action, but which will remain intact without injury to the contents under normal conditions.
- a tablet comprising a compressed mass of powder material having a pervious coating of liquid insoluble material and an interior structural formation of the coating material preventing the disintegration of the tablet under normal condition.
- a tablet comprising a compressed mass of powder material having a ervious coating of parafin and, an interior structural formation of paraiiin preventing the disintegration of th tablet under normal condition.
- a tablet comprising a compressed mass of a ar-lac having a pervious coating of n and an interior structural forma tion of parafifin preventing the disintegration of the tablet under normal condition.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
Description
Patented June 24, 1924.
FBEDERIC S. MASON, OF NEW YORK, N. Y.v
' TABLET.
No Drawing.
To all whom it may concern:
Be it known that I, Fniinr'inic S. MAsoN, a citizen of the United States, residing at New York city, county of New York, borough of Manhattan, and State of New York, have invented new and' useful Improvements in Tablets, of which the following is a full, clear, and exact specification.
My invention relates to tablets and refers particularly to medicinal tablets and processes for producing the same.
One object of my invention is a non-friable tablet.
Another object of my invention is a tabletcomprising a friable material enclosed Within a liquid pervious cover of such structural strength as topreserve the tablet in a nondisintegrable condition under normal conditions.
Many medicinal compounds, because of their physical condition, their hygroscopic properties, or for other reasons, are incapable of being formed, or compressed, into tablet, pill, or similar forms With any considerable degree of permanency.
They, therefore, gradually crumble, or disintegrate, making it impossible to obtain the required dosage quantity.
It is evident that any covering, orcoating, for medicinal tablets of this character must be of such material or in such physical condition as to allow of the ready and positive breaking down of the tablet when taken internally, in order to obtain the full efliciency of the contained medicinal products.
Great difficulty has been experienced in accomplishing these desired results with medicinal products which are hygroscopic or which are deleteriously affected by water, alcohol or other solvents necessary in dissolving the coating material for purposes of application to the tablet.
For the above reasons, it has been found impossible to effectively coat, or cover, many medicinal products, and hence, their use has been limited to their powder form, with all of the evident disadvantages of powders over definitely quantitative tablets.
I have discovered a means whereby products which are friable, hygroscopic and sensitive to liquids may be formed into tablets:
which are stable in construction and in which the contents are not affected by ordinary atmospheric conditions and which have full efliciency of contents.
I have found that compressed tablets of Application flled'August 19, 1922. Serial No. 583,028.
materials having the above described propertiesmay be covered with a' coating of certain waxes and similar products with the formation of a product which is pervious to aqueous liquid, resulting in a breaking down of the tablet forefiiciency of physiological action, but which will remain intact without injury to the contents under normal conditions.
While I do not limit myself to the use of paraffin, I have found that that product is particularly adaptable for the process of my invention.
As an example of the following of my process, I take tablets of agar-lac, which is friable, hygroscopic and not compressible to tablets containing agar-agar with cul- 1tures of lactic ferments and phenolphthaem.
An examination of the tablets produced by'the process of my invention seems to-indicate that during the immersion of the tablet mass within the molten paraflin, the latter penetrates the mass in irregular manner producing a structural formation that might be called a skeleton support for the tablet mass, the valuable effect of which is further augmented by a thin and. usually irregular and broken paraflin covering over the exterior surface of the tablet. This parafiin formation acts to support the mass and to protect it from ordinary atmospheric condition, but allows it to be readily broken down in the presence of a liquid and especially a liquid of the'temperature of the stomach and intestines.
value, particularly those containing medicinal products.
I do not limit myself to the particular products or steps of process mentioned, or described, as these are given simply as an example for theclearer description of the process of my invention and t e products produced thereby.
What ll claim is v 1. The process of increasing the non-friability of powder tablets which comprises treating a friable potwder tablet with a liquid insoluble material forming a pervious coating thereon and an interior structural formation of the treating material, preventing disintegration of the tablet under nor mal conditions.
2. The process of increasing the non-friability of powder tablets which comprises treating a friable powder tablet with melted and an interior structural formation of par- .para
neeaeee aftin preventing disintegration of the tablet I under normal conditions.
a. A tablet comprising a compressed mass of powder material having a pervious coating of liquid insoluble material and an interior structural formation of the coating material preventing the disintegration of the tablet under normal condition.
5. A tablet comprising a compressed mass of powder material having a ervious coating of parafin and, an interior structural formation of paraiiin preventing the disintegration of th tablet under normal condition.
6. A tablet comprising a compressed mass of a ar-lac having a pervious coating of n and an interior structural forma tion of parafifin preventing the disintegration of the tablet under normal condition.
Signed at New York city, in the county or New York and gtate of New York, this 16th day of August, 1922.
renneero s, Mason.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US583028A US1498666A (en) | 1922-08-19 | 1922-08-19 | Tablet |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US583028A US1498666A (en) | 1922-08-19 | 1922-08-19 | Tablet |
Publications (1)
Publication Number | Publication Date |
---|---|
US1498666A true US1498666A (en) | 1924-06-24 |
Family
ID=24331389
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US583028A Expired - Lifetime US1498666A (en) | 1922-08-19 | 1922-08-19 | Tablet |
Country Status (1)
Country | Link |
---|---|
US (1) | US1498666A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2665236A (en) * | 1950-11-28 | 1954-01-05 | Morton Salt Co | Impregnated salt tablet |
US4639255A (en) * | 1980-01-15 | 1987-01-27 | Phillips Petroleum Company | Solid form additives and method of forming same |
-
1922
- 1922-08-19 US US583028A patent/US1498666A/en not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2665236A (en) * | 1950-11-28 | 1954-01-05 | Morton Salt Co | Impregnated salt tablet |
US4639255A (en) * | 1980-01-15 | 1987-01-27 | Phillips Petroleum Company | Solid form additives and method of forming same |
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