US1304600A - Composition of matter for plasters - Google Patents
Composition of matter for plasters Download PDFInfo
- Publication number
- US1304600A US1304600A US1304600DA US1304600A US 1304600 A US1304600 A US 1304600A US 1304600D A US1304600D A US 1304600DA US 1304600 A US1304600 A US 1304600A
- Authority
- US
- United States
- Prior art keywords
- plaster
- starch
- matter
- gelatin
- plasters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title description 24
- 229920002472 Starch Polymers 0.000 description 28
- 239000008107 starch Substances 0.000 description 28
- 239000011505 plaster Substances 0.000 description 26
- 235000019698 starch Nutrition 0.000 description 26
- 108010010803 Gelatin Proteins 0.000 description 20
- 229920000159 gelatin Polymers 0.000 description 20
- 239000008273 gelatin Substances 0.000 description 20
- 235000019322 gelatine Nutrition 0.000 description 20
- 235000011852 gelatine desserts Nutrition 0.000 description 20
- 239000003814 drug Substances 0.000 description 14
- 235000011187 glycerol Nutrition 0.000 description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- KGBXLFKZBHKPEV-UHFFFAOYSA-N Boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 8
- 238000009835 boiling Methods 0.000 description 8
- 239000004327 boric acid Substances 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 8
- 239000011159 matrix material Substances 0.000 description 8
- 229920000742 Cotton Polymers 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 6
- 241000219198 Brassica Species 0.000 description 4
- 235000003351 Brassica cretica Nutrition 0.000 description 4
- 235000003343 Brassica rupestris Nutrition 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 235000010460 mustard Nutrition 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 239000000341 volatile oil Substances 0.000 description 4
- 235000002566 Capsicum Nutrition 0.000 description 2
- 240000008574 Capsicum frutescens Species 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive Effects 0.000 description 2
- 239000001390 capsicum minimum Substances 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- -1 glycerin compound Chemical class 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000002452 interceptive Effects 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 230000002335 preservative Effects 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000003405 preventing Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000001225 therapeutic Effects 0.000 description 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
Definitions
- My invention relates to compositions of matter suitable for plasters .or ointmentsand comprises a compound. which, while sufiiciently soft and flexible at ordina body and atmospheric temperatures, wil
- the preferred method of forming a plaster out of my improved composition of matter is the followmg: I add two ounds of cold water to one and a half poun sof gelatin and stir well, allowing the mixture to stand until the water is thoroughly absorbed by the gelatin. To this I then add four pounds of glycerin and one ounce of boric acid, and boil the mixture in a water bath for about four hours, until the gelatin is entirely dissolved. I then add the nine or ten ounces of commercial starch, such as is used for laundry purposes, which has been first dissolved in one quart of cold water.” This (igelatin-glycerin-starch solution is then raise to the boiling point, and kept ima state of ebullition for three or four minutes. According to my present understanding this Specification of Letters Patent.
- the glycerin compound is allowed to stand over the'water bath for about two hours. It is thenallowed.
- the cotton may be omitted.
- the starch is partly to assist in the above described actiombut principally to prevent the compound from liquetying by the absorption of moisture from the atmosphere or from the pores of the paobjects. lVhen the starch is ended in proper I proportion these last mentioned diiiiculties are avoided Without interfering with the releasing of the medicaments for their desired therapeutic action when the plaster is ap plied to a patients body.
- a plaster designed to serve as a matrix for medicaments which comprises a mixture of gelatin, glycerin and starch the gelatin occurring in suiliciently large proportion to give the mixture solidity Without hardness at ordinary atmospheric temperatures, and the starch occurring in the completed mixture as boiled starch and in suificiently large rsoasoo proportion to prevent the plaster liquefying by absorption of moisture from the atmosphere or from the body of the patient. 5
- a plaster such as set forth in claim 1, -which also contains 'a preservative componentsuch as boric acid.
- a plaster designed to serve as a matrix for medicaments which comprises gelatin, glycerin and starch intimately comniingled and boiled together, the gelatin occurring in sufficiently large proportion to give the mixture solidity Without hardness at ordinary atmospheric temperatures, and the starch occurring in suiiiciently large proportion to prevent the plaster liquefying by absorptioniof moisture from the atmosphere or from the body of the patient.
- a plaster such as set forth in claim 3 which also contains a fermentation prevent ing component such as boric acid.
- a medical plaster comprising the following elements intimately commingled and boiled together in approximately the following proportions: gelatin, 2-1 parts; glycerin, 6a parts; starch,
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Description
No Drawing.
I To all whom it may concern:
UNITED STATES;
PATENT union.
EDMUND MORSE POND, 0E RUTLAND, VERMONT, ASSIGNOR, ZBY MESNE.ASSIGNMENTS,
1 TO KATHERINE B. POND, OF RUTIJAND, VERMONT.
COMPOSITION OF MATTER FOB PLASTERS, OINTMENTS, &o.
Be it known that I, EDMUND Monsn Form, a citizen of the United States of America,
residing at Rutland, county of Rutland,
State of Vermont, have invented certain new and useful Improvements in Compositions of Matter for Plaster-s, 'Ointments', &c., of which the following is a specification.
5 My invention relates to compositions of matter suitable for plasters .or ointmentsand comprises a compound. which, while sufiiciently soft and flexible at ordina body and atmospheric temperatures, wil
not run at the higher temperatures of the body of a fever patient. The feature. of
permanent solidity under these conditions is due to the inclusion of starch in the formula, and has been attained onlyafter years of experiment in. hospital and private practice with compositionsof the general character herein set out. My preferred formula,
for general use. includes the following ingredients in substantially the proportions set out, by. weight:
Gelatin 24 parts. Glycerin 64 Boric acid 1 .Starch '9 The proportion of starch may be varied are employed.
The preferred method of forming a plaster out of my improved composition of matter is the followmg: I add two ounds of cold water to one and a half poun sof gelatin and stir well, allowing the mixture to stand until the water is thoroughly absorbed by the gelatin. To this I then add four pounds of glycerin and one ounce of boric acid, and boil the mixture in a water bath for about four hours, until the gelatin is entirely dissolved. I then add the nine or ten ounces of commercial starch, such as is used for laundry purposes, which has been first dissolved in one quart of cold water." This (igelatin-glycerin-starch solution is then raise to the boiling point, and kept ima state of ebullition for three or four minutes. According to my present understanding this Specification of Letters Patent.
oughly cook the starch and thicken it with Patented May 27, 1919. Application filed August 5, 1914. Serial No. 855,304.
the glycerin compound. Thereafter the compound is allowed to stand over the'water bath for about two hours. It is thenallowed.
to slightly cool, if volatile oils or other medication is to be added, so as not to evaporate them. For'some purposes I employ, as such medication, for example,-twenty-five drops of oil of mustard, two drams of capsicum, and seven ounces of methyl salicylatewhich are thoroughly. stirred into the mixture at this time.
I then place on a suitable frame a layer of white paper waxed on one side, with the unwaxed side uppermost, then a layer of cotton Wadding, and on that a layerof gauze. The composition produced as above described is then poured hot on these layers of fabric and rubbed'through the gauze and cotton to the paper. After a few minutes the whole mass hardens sufficiently to permit of its being taken from th frame. The plaster is then-allowed to dry about four days before being acked forcommercial use. Before applymg the plaster to the patients body it should be slightly heated.
For thin plasters, the cotton may be omitted.
Among the advantages of this plaster may be mentioned the fact that while it remains soft, moist and flexible while in contact with the body, it will not run over the person or clothing, nor will it become too soft in the hottest weather. Being solid in body, it holds medication well, and even the most volatile constituents, such as oil of mustard, will 'not escape from' it either in manufac ture, storage, or use. -It is slightly adhesive when heated, thus aiding in holding itself in placeon the patients body, and yet it is soft as a oultice and holds the most volatile oils -ordinary temperatures. of the atmos ere and that of the flesh of thepatient to w ich is the givingof body or solidity thug at it is applied. The proportion of gelatin 7 should be high enough to effect this without producing hardness. As a result it enables the compound to serve as a matrix for holding the glycerin and other 'medicaments,
from which matrix they may be given up for absorption by the pores of the patients body.
when the plaster is put into use.
The function or" the starch is partly to assist in the above described actiombut principally to prevent the compound from liquetying by the absorption of moisture from the atmosphere or from the pores of the paobjects. lVhen the starch is ended in proper I proportion these last mentioned diiiiculties are avoided Without interfering with the releasing of the medicaments for their desired therapeutic action when the plaster is ap plied to a patients body.
Having, therefore, described my invention, I claim:
1. A plaster designed to serve as a matrix for medicaments which comprises a mixture of gelatin, glycerin and starch the gelatin occurring in suiliciently large proportion to give the mixture solidity Without hardness at ordinary atmospheric temperatures, and the starch occurring in the completed mixture as boiled starch and in suificiently large rsoasoo proportion to prevent the plaster liquefying by absorption of moisture from the atmosphere or from the body of the patient. 5
2. A plaster such as set forth in claim 1, -which also contains 'a preservative componentsuch as boric acid.
3. A plaster designed to serve as a matrix for medicaments Which comprises gelatin, glycerin and starch intimately comniingled and boiled together, the gelatin occurring in sufficiently large proportion to give the mixture solidity Without hardness at ordinary atmospheric temperatures, and the starch occurring in suiiiciently large proportion to prevent the plaster liquefying by absorptioniof moisture from the atmosphere or from the body of the patient.
4. A plaster such as set forth in claim 3 which also contains a fermentation prevent ing component such as boric acid.
5. As an article of manufacture a medical plaster comprising the following elements intimately commingled and boiled together in approximately the following proportions: gelatin, 2-1 parts; glycerin, 6a parts; starch,
10 parts.
EDMUND MORSE POND. lVitnesses JAMES A. MURRILL, FRANK D. VVTHITE.
Publications (1)
Publication Number | Publication Date |
---|---|
US1304600A true US1304600A (en) | 1919-05-27 |
Family
ID=3372131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US1304600D Expired - Lifetime US1304600A (en) | Composition of matter for plasters |
Country Status (1)
Country | Link |
---|---|
US (1) | US1304600A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2464755A (en) * | 1946-07-09 | 1949-03-15 | Vodol Company | Coated gauze |
US2899362A (en) * | 1959-08-11 | Hemostatic sponges and method of | ||
US4143126A (en) * | 1977-07-01 | 1979-03-06 | Colgate Palmolive Company | Dental prophylactic paste |
-
0
- US US1304600D patent/US1304600A/en not_active Expired - Lifetime
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2899362A (en) * | 1959-08-11 | Hemostatic sponges and method of | ||
US2464755A (en) * | 1946-07-09 | 1949-03-15 | Vodol Company | Coated gauze |
US4143126A (en) * | 1977-07-01 | 1979-03-06 | Colgate Palmolive Company | Dental prophylactic paste |
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