US11147971B2 - Systems methods and devices for closed loop stimulation to enhance stroke recovery - Google Patents
Systems methods and devices for closed loop stimulation to enhance stroke recovery Download PDFInfo
- Publication number
- US11147971B2 US11147971B2 US16/311,309 US201716311309A US11147971B2 US 11147971 B2 US11147971 B2 US 11147971B2 US 201716311309 A US201716311309 A US 201716311309A US 11147971 B2 US11147971 B2 US 11147971B2
- Authority
- US
- United States
- Prior art keywords
- subject
- stimulation
- electrode
- current
- brain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active, expires
Links
- 230000000638 stimulation Effects 0.000 title claims abstract description 112
- 238000000034 method Methods 0.000 title claims abstract description 38
- 238000011084 recovery Methods 0.000 title claims abstract description 34
- 230000010355 oscillation Effects 0.000 claims abstract description 39
- 210000004556 brain Anatomy 0.000 claims abstract description 31
- 230000007659 motor function Effects 0.000 claims abstract description 19
- 238000004891 communication Methods 0.000 claims abstract description 14
- 230000001737 promoting effect Effects 0.000 claims abstract description 8
- 230000000694 effects Effects 0.000 claims description 33
- 230000004044 response Effects 0.000 claims description 10
- 238000002567 electromyography Methods 0.000 claims description 8
- 210000003205 muscle Anatomy 0.000 claims description 8
- 206010051290 Central nervous system lesion Diseases 0.000 claims description 7
- 230000001960 triggered effect Effects 0.000 claims description 7
- 238000001514 detection method Methods 0.000 claims description 6
- 210000001638 cerebellum Anatomy 0.000 claims description 2
- 210000001103 thalamus Anatomy 0.000 claims description 2
- 210000004227 basal ganglia Anatomy 0.000 claims 1
- 210000000133 brain stem Anatomy 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 241001465754 Metazoa Species 0.000 description 73
- 208000006011 Stroke Diseases 0.000 description 62
- 230000001537 neural effect Effects 0.000 description 26
- 230000006870 function Effects 0.000 description 14
- 210000002569 neuron Anatomy 0.000 description 14
- 239000000523 sample Substances 0.000 description 14
- 238000002474 experimental method Methods 0.000 description 13
- 230000006872 improvement Effects 0.000 description 12
- 238000012421 spiking Methods 0.000 description 12
- 238000007427 paired t-test Methods 0.000 description 11
- 238000004458 analytical method Methods 0.000 description 9
- 230000006399 behavior Effects 0.000 description 9
- 230000008859 change Effects 0.000 description 9
- 238000012549 training Methods 0.000 description 9
- 238000000692 Student's t-test Methods 0.000 description 8
- 239000008188 pellet Substances 0.000 description 8
- 210000003625 skull Anatomy 0.000 description 8
- 238000012353 t test Methods 0.000 description 8
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 7
- 238000003491 array Methods 0.000 description 7
- 230000006378 damage Effects 0.000 description 7
- 229960003299 ketamine Drugs 0.000 description 7
- 230000003902 lesion Effects 0.000 description 7
- 206010002091 Anaesthesia Diseases 0.000 description 6
- 241000700159 Rattus Species 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 6
- 230000009471 action Effects 0.000 description 6
- 230000037005 anaesthesia Effects 0.000 description 6
- 238000004364 calculation method Methods 0.000 description 6
- 238000007428 craniotomy Methods 0.000 description 6
- 238000002513 implantation Methods 0.000 description 6
- 208000014674 injury Diseases 0.000 description 6
- 238000012544 monitoring process Methods 0.000 description 6
- 230000003534 oscillatory effect Effects 0.000 description 6
- 230000003542 behavioural effect Effects 0.000 description 5
- 230000001054 cortical effect Effects 0.000 description 5
- 230000006735 deficit Effects 0.000 description 5
- 230000006698 induction Effects 0.000 description 5
- 230000002093 peripheral effect Effects 0.000 description 5
- 206010001497 Agitation Diseases 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- 210000003194 forelimb Anatomy 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 4
- 229960001600 xylazine Drugs 0.000 description 4
- 241000282412 Homo Species 0.000 description 3
- 241000283984 Rodentia Species 0.000 description 3
- 206010042008 Stereotypy Diseases 0.000 description 3
- 238000012937 correction Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000000763 evoking effect Effects 0.000 description 3
- 230000001771 impaired effect Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 210000000337 motor cortex Anatomy 0.000 description 3
- 238000012898 one-sample t-test Methods 0.000 description 3
- 230000002085 persistent effect Effects 0.000 description 3
- 230000035484 reaction time Effects 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 230000002123 temporal effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 3
- 230000003444 anaesthetic effect Effects 0.000 description 2
- 238000000540 analysis of variance Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000002001 electrophysiology Methods 0.000 description 2
- 230000007831 electrophysiology Effects 0.000 description 2
- 238000010304 firing Methods 0.000 description 2
- 238000012806 monitoring device Methods 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 230000000449 premovement Effects 0.000 description 2
- 210000000463 red nucleus Anatomy 0.000 description 2
- 230000002739 subcortical effect Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 229910052721 tungsten Inorganic materials 0.000 description 2
- 239000010937 tungsten Substances 0.000 description 2
- 238000011870 unpaired t-test Methods 0.000 description 2
- IICCLYANAQEHCI-UHFFFAOYSA-N 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodospiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C(C(=C(Cl)C(Cl)=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 IICCLYANAQEHCI-UHFFFAOYSA-N 0.000 description 1
- 229930003347 Atropine Natural products 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 229920001651 Cyanoacrylate Polymers 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 1
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 description 1
- MWCLLHOVUTZFKS-UHFFFAOYSA-N Methyl cyanoacrylate Chemical compound COC(=O)C(=C)C#N MWCLLHOVUTZFKS-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000009328 Perro Species 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 1
- 206010038678 Respiratory depression Diseases 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 101150071882 US17 gene Proteins 0.000 description 1
- 230000036982 action potential Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 1
- 229960000396 atropine Drugs 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000007177 brain activity Effects 0.000 description 1
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 description 1
- 229960001736 buprenorphine Drugs 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000009537 cortical lesion Effects 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 239000003479 dental cement Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 230000009699 differential effect Effects 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000002566 electrocorticography Methods 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 210000003191 femoral vein Anatomy 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 210000005153 frontal cortex Anatomy 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000003447 ipsilateral effect Effects 0.000 description 1
- 229960002725 isoflurane Drugs 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 229960001929 meloxicam Drugs 0.000 description 1
- 210000001577 neostriatum Anatomy 0.000 description 1
- 230000007383 nerve stimulation Effects 0.000 description 1
- 230000004751 neurological system process Effects 0.000 description 1
- 230000003227 neuromodulating effect Effects 0.000 description 1
- 230000004007 neuromodulation Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000010149 post-hoc-test Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011808 rodent model Methods 0.000 description 1
- 229930187593 rose bengal Natural products 0.000 description 1
- 229940081623 rose bengal Drugs 0.000 description 1
- STRXNPAVPKGJQR-UHFFFAOYSA-N rose bengal A Natural products O1C(=O)C(C(=CC=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 STRXNPAVPKGJQR-UHFFFAOYSA-N 0.000 description 1
- 238000013515 script Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 description 1
- 229960004306 sulfadiazine Drugs 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000011491 transcranial magnetic stimulation Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36103—Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0529—Electrodes for brain stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36003—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of motor muscles, e.g. for walking assistance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
- A61N1/36031—Control systems using physiological parameters for adjustment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
Definitions
- the method involves recording activity from perilesional regions of the subject's brain. Through the recording of perilesional activity, the method seeks to detect LFOs, which have been surprisingly found to correspond to motor task learning/relearning during recovery. In certain implementations, the method further involves the application of discrete pulses of CS to perilesional regions which has been surprisingly found to potentiate motor task related LFOs, which thereby enhances relearning and recovery of motor function.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Physiology (AREA)
- Cardiology (AREA)
- Developmental Disabilities (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Social Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rehabilitation Therapy (AREA)
- Electrotherapy Devices (AREA)
Abstract
Description
Claims (18)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/311,309 US11147971B2 (en) | 2016-06-24 | 2017-06-26 | Systems methods and devices for closed loop stimulation to enhance stroke recovery |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662354543P | 2016-06-24 | 2016-06-24 | |
US16/311,309 US11147971B2 (en) | 2016-06-24 | 2017-06-26 | Systems methods and devices for closed loop stimulation to enhance stroke recovery |
PCT/US2017/039293 WO2017223564A1 (en) | 2016-06-24 | 2017-06-26 | Systems methods and devices for closed-loop stimulation to enhance stroke recovery |
Publications (2)
Publication Number | Publication Date |
---|---|
US20190232061A1 US20190232061A1 (en) | 2019-08-01 |
US11147971B2 true US11147971B2 (en) | 2021-10-19 |
Family
ID=60784804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US16/311,309 Active 2037-07-28 US11147971B2 (en) | 2016-06-24 | 2017-06-26 | Systems methods and devices for closed loop stimulation to enhance stroke recovery |
Country Status (3)
Country | Link |
---|---|
US (1) | US11147971B2 (en) |
EP (1) | EP3458147B1 (en) |
WO (1) | WO2017223564A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210316144A1 (en) * | 2018-07-19 | 2021-10-14 | The Regents Of The University Of California | Systems Methods And Devices For Closed-Loop Stimulation To Enhance Stroke Recovery |
ES2882087T3 (en) | 2018-08-17 | 2021-12-01 | Corstim | An apparatus for electrical stimulation of the brain based on closed-circuit models |
US11093038B2 (en) | 2019-05-14 | 2021-08-17 | Synchron Australia Pty Limited | Systems and methods for generic control using a neural signal |
AU2020373042A1 (en) | 2019-10-29 | 2022-06-16 | Synchron Australia Pty Limited | Systems and methods for configuring a brain control interface using data from deployed systems |
EP4287947A4 (en) * | 2021-02-03 | 2025-01-15 | Synchron Australia Pty Ltd | NEUROMONITORING DIAGNOSTIC SYSTEMS |
US12186564B2 (en) * | 2021-02-09 | 2025-01-07 | The Regents Of The University Of California | Methods and apparatuses for treating stroke using low-frequency stimulation |
WO2023137427A1 (en) | 2022-01-13 | 2023-07-20 | Synchron Australia Pty Limited | Systems and methods for generic control using a neural signal |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060015153A1 (en) | 2004-07-15 | 2006-01-19 | Gliner Bradford E | Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy |
WO2007138598A2 (en) | 2006-06-01 | 2007-12-06 | Tylerton International Inc. | Brain stimulation and rehabilitation |
US20080114417A1 (en) * | 2006-11-14 | 2008-05-15 | Leyde Kent W | Systems and methods of reducing artifact in neurological stimulation systems |
US20100069995A1 (en) * | 2008-09-11 | 2010-03-18 | Ingela Danielsson | Method for Improving Functional Recovery After Stroke by Electrical Stimulation of a Cranial Nerve |
US20110213440A1 (en) | 2006-04-11 | 2011-09-01 | Brad Fowler | Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods |
US20110218588A1 (en) * | 2010-03-04 | 2011-09-08 | Yesu Hospital Management Foundation | Implantable cortical electrical stimulation appratus having wireless power supply control function |
WO2015069632A1 (en) | 2013-11-05 | 2015-05-14 | The University Of North Carolina At Chapel Hill | Methods, apparatuses and systems for transcranial stimulation |
US9113912B1 (en) * | 2015-01-21 | 2015-08-25 | Serene Medical, Inc. | Systems and devices to identify and limit nerve conduction |
US20160022168A1 (en) * | 2014-07-24 | 2016-01-28 | University Of Lethbridge | Brain state dependent therapy for improved neural training and rehabilitation |
US20160220836A1 (en) * | 2015-01-30 | 2016-08-04 | Board Of Trustees Of The University Of Arkansas | Device and method of phase-locking brain stimulation to electroencephalographic rhythms |
-
2017
- 2017-06-26 WO PCT/US2017/039293 patent/WO2017223564A1/en unknown
- 2017-06-26 US US16/311,309 patent/US11147971B2/en active Active
- 2017-06-26 EP EP17816375.4A patent/EP3458147B1/en active Active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060015153A1 (en) | 2004-07-15 | 2006-01-19 | Gliner Bradford E | Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy |
US20110213440A1 (en) | 2006-04-11 | 2011-09-01 | Brad Fowler | Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods |
WO2007138598A2 (en) | 2006-06-01 | 2007-12-06 | Tylerton International Inc. | Brain stimulation and rehabilitation |
US20080114417A1 (en) * | 2006-11-14 | 2008-05-15 | Leyde Kent W | Systems and methods of reducing artifact in neurological stimulation systems |
US20100069995A1 (en) * | 2008-09-11 | 2010-03-18 | Ingela Danielsson | Method for Improving Functional Recovery After Stroke by Electrical Stimulation of a Cranial Nerve |
US20110218588A1 (en) * | 2010-03-04 | 2011-09-08 | Yesu Hospital Management Foundation | Implantable cortical electrical stimulation appratus having wireless power supply control function |
WO2015069632A1 (en) | 2013-11-05 | 2015-05-14 | The University Of North Carolina At Chapel Hill | Methods, apparatuses and systems for transcranial stimulation |
US20160022168A1 (en) * | 2014-07-24 | 2016-01-28 | University Of Lethbridge | Brain state dependent therapy for improved neural training and rehabilitation |
US9113912B1 (en) * | 2015-01-21 | 2015-08-25 | Serene Medical, Inc. | Systems and devices to identify and limit nerve conduction |
US20160220836A1 (en) * | 2015-01-30 | 2016-08-04 | Board Of Trustees Of The University Of Arkansas | Device and method of phase-locking brain stimulation to electroencephalographic rhythms |
Non-Patent Citations (2)
Title |
---|
Tanuj Gulati et al., "Robust Neuroprosthetic Control from the Stroke Perilesional Cortex", "The Journal of Neuroscience", Jun. 3, 2015, pp. 8653-8661, vol. 35, No. 22. |
Walter et al., "Dynamics of a Stimulation-evoked ECoG Potential During Stroke Rehabiliation—A Case Study", "Proceedings of the International Congress on Neurotechnology, Electronics and Informatics (BrainRehab-2013)", Jan. 1, 2013, pp. 241-248, Publisher: Science and Technology Publications, Lda. |
Also Published As
Publication number | Publication date |
---|---|
WO2017223564A1 (en) | 2017-12-28 |
EP3458147B1 (en) | 2023-01-04 |
EP3458147A1 (en) | 2019-03-27 |
US20190232061A1 (en) | 2019-08-01 |
EP3458147A4 (en) | 2020-01-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11147971B2 (en) | Systems methods and devices for closed loop stimulation to enhance stroke recovery | |
US10238862B2 (en) | Extracranial implantable devices, systems and methods for the treatment of medical disorders | |
US10639468B2 (en) | Devices, systems and methods for the treatment of medical disorders | |
CN106999088B (en) | System and method for monitoring muscle rehabilitation | |
US9162051B2 (en) | Treatment of language, behavior and social disorders | |
EP3065815B1 (en) | Methods, apparatuses and systems for transcranial stimulation | |
US7353064B2 (en) | Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of movement disorders and/or other neurologic dysfunction | |
US7634315B2 (en) | Techniques to monitor and trend nerve damage and recovery | |
Nelson et al. | Closed-loop seizure control with very high frequency electrical stimulation at seizure onset in the GAERS model of absence epilepsy | |
US11103691B2 (en) | Peripheral nerve stimulation for restless legs syndrome | |
US20140336722A1 (en) | Method and neuroprosthetic device for monitoring and suppression of pathological tremors through neurostimulation of the afferent pathways | |
US20210316144A1 (en) | Systems Methods And Devices For Closed-Loop Stimulation To Enhance Stroke Recovery | |
US12186547B2 (en) | Peripheral nerve stimulation for Restless Legs Syndrome | |
HK1206664A1 (en) | Method and apparatus for the treatment of focal dystonia | |
Murakami et al. | High-frequency oscillations change in parallel with short-interval intracortical inhibition after theta burst magnetic stimulation | |
Di Pino et al. | Overview of the implant of intraneural multielectrodes in human for controlling a 5-fingered hand prosthesis, delivering sensorial feedback and producing rehabilitative neuroplasticity | |
JP2024508685A (en) | Intrastimulus recruitment control | |
Huang et al. | Reduction in excitability of the auditory nerve following electrical stimulation at high stimulus rates. IV. Effects of stimulus intensity | |
McDonnall et al. | Restoration of blink in facial paralysis patients using FES | |
EP1824559A2 (en) | Passive monitoring of bioelectical signals and active electrical anesthesia stimulation | |
Boulay et al. | Electrocorticographic activity over sensorimotor cortex and motor function in awake behaving rats | |
US20250222250A1 (en) | Peripheral nerve stimulation for restless legs syndrome | |
US20250135201A1 (en) | Selective neurostimulation of peripheral nerves with reduced off-target activation | |
Boulay | Cortical-spinal interactions in skill acquisition and performance and their implications for rehabilitation | |
Fisher et al. | Blocking Central Pathways in the Primate Motor |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FEPP | Fee payment procedure |
Free format text: ENTITY STATUS SET TO UNDISCOUNTED (ORIGINAL EVENT CODE: BIG.); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY |
|
FEPP | Fee payment procedure |
Free format text: ENTITY STATUS SET TO SMALL (ORIGINAL EVENT CODE: SMAL); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: APPLICATION DISPATCHED FROM PREEXAM, NOT YET DOCKETED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: RESPONSE TO NON-FINAL OFFICE ACTION ENTERED AND FORWARDED TO EXAMINER |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: FINAL REJECTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NOTICE OF ALLOWANCE MAILED -- APPLICATION RECEIVED IN OFFICE OF PUBLICATIONS |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: AWAITING TC RESP., ISSUE FEE NOT PAID |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NOTICE OF ALLOWANCE MAILED -- APPLICATION RECEIVED IN OFFICE OF PUBLICATIONS |
|
AS | Assignment |
Owner name: DEPARTMENT OF VETERANS AFFAIRS, DISTRICT OF COLUMBIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:GANGULY, KARUNESH;GULATI, TANUJ;RAMANATHAN, DHAKSHIN;REEL/FRAME:057533/0890 Effective date: 20170615 Owner name: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:GANGULY, KARUNESH;GULATI, TANUJ;RAMANATHAN, DHAKSHIN;REEL/FRAME:057533/0890 Effective date: 20170615 |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: PUBLICATIONS -- ISSUE FEE PAYMENT VERIFIED |
|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
MAFP | Maintenance fee payment |
Free format text: PAYMENT OF MAINTENANCE FEE, 4TH YR, SMALL ENTITY (ORIGINAL EVENT CODE: M2551); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY Year of fee payment: 4 |