US10632132B2 - Methods for treating heart transplant rejection - Google Patents
Methods for treating heart transplant rejection Download PDFInfo
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- US10632132B2 US10632132B2 US16/256,235 US201916256235A US10632132B2 US 10632132 B2 US10632132 B2 US 10632132B2 US 201916256235 A US201916256235 A US 201916256235A US 10632132 B2 US10632132 B2 US 10632132B2
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- A61K31/60—Salicylic acid; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Definitions
- Heart transplantation is currently the only definitive solution when a heart has total failure of its functions.
- allografts of the heart are usually performed, necessarily carrying immunosuppression protocols to avoid acute rejection.
- chronic rejection has not yet been successfully managed.
- the side effects associated with the chronic use of immunosupressants constitute a therapeutic problem due to their toxicity and the fact that they generate a global immunodepression to the patient.
- therapeutic strategies are sought to avoid their chronic use and high doses of them.
- all therapies to avoid the rejection of allotransplantation had as objective the manipulation of the adaptive immunity.
- a novel therapeutic protocol which includes a combination with classical immunosuppressants (administered in low doses and short duration) in order to obtain synergistic and long-term effects for allograft survival.
- One embodiment of the described invention is a therapeutic approach to treat heart allotransplantation rejection based on the inflammasome inhibition with a new anti-inflammatory nitroalkene.
- the one or more secondary therapeutic agents is selected from the group consisting of calcineurin inhibitors, corticosteroids, cytotoxic immunosuppressants, immunosuppressant antibodies, sirolimus derivatives, other immunosuppressants, and any combination thereof.
- composition further comprises one or more secondary therapeutic agents.
- the pharmaceutical composition further comprises one or more secondary therapeutic agents selected from the group consisting of calcineurin inhibitors, corticosteroids, cytotoxic immunosuppressants, immunosuppressant antibodies, sirolimus derivatives, other immunosuppressants, and any combination thereof.
- FIG. 1 demonstrates the inhibitory effect of SANA on NF- ⁇ B and NLRP3 inflamasome-dependent IL-1 ⁇ release in the plasma of C57BL/6 mice.
- FIG. 2 demonstrates the inhibitory effect of SANA on NF- ⁇ B and NLRP3 inflamasome-dependent IL-1 ⁇ release in the peritoneum of C57BL/6 mice.
- FIG. 3 demonstrates prolonged survival for fully mismatched heterotopic heart allograft in rat models treated with SANA.
- the term “about” means plus or minus 5% of the numerical value of the number with which it is being used. Therefore, about 50% means in the range of 45%-55%.
- administering when used in conjunction with a therapeutic means to administer a therapeutic directly to a subject, whereby the agent positively impacts the target.
- administering a composition may be accomplished by, for example, injection, oral administration, topical administration, or by these methods in combination with other known techniques. Such combination techniques include heating, radiation, ultrasound and the use of delivery agents.
- administration and its variants are each understood to include concurrent and sequential provision of the compound or salt and other agents.
- pharmaceutically acceptable it is meant the carrier, diluent, adjuvant, or excipient must be compatible with the other ingredients of the formulation and not deleterious to the recipient thereof.
- composition as used herein is intended to encompass a product comprising the specified ingredients in the specified amounts, as well as any product which results, directly or indirectly, from combination of the specified ingredients in the specified amounts.
- pharmaceutical composition is intended to encompass a product comprising the active ingredient(s), and the inert ingredient(s) that make up the carrier, as well as any product which results, directly or indirectly, from combination, complexation or aggregation of any two or more of the ingredients, or from dissociation of one or more of the ingredients, or from other types of reactions or interactions of one or more of the ingredients.
- the pharmaceutical compositions of the present invention encompass any composition made by admixing a compound of the present invention and a pharmaceutically acceptable carrier.
- agent means a compound or composition utilized to treat, combat, ameliorate, prevent or improve an unwanted condition or disease of a patient.
- agent active agent
- therapeutic agent therapeutic agent
- a “therapeutically effective amount” or “effective amount” of a composition is a predetermined amount calculated to achieve the desired effect, i.e., to inhibit, block, or reverse the activation, migration, proliferation, alteration of cellular function, and to preserve the normal function of cells.
- the activity contemplated by the methods described herein includes both medical therapeutic and/or prophylactic treatment, as appropriate, and the compositions of the invention may be used to provide improvement in any of the conditions described. It is also contemplated that the compositions described herein may be administered to healthy subjects or individuals not exhibiting symptoms but who may be at risk of developing a particular disorder.
- a therapeutically effective amount of compound of this invention is typically an amount such that when it is administered in a physiologically tolerable excipient composition, it is sufficient to achieve an effective systemic concentration or local concentration in the tissue.
- treat refers to both therapeutic treatment and prophylactic or preventative measures, wherein the object is to prevent or slow down (lessen) an undesired physiological condition, disorder, or disease, or to obtain beneficial or desired clinical results.
- beneficial or desired results include, but are not limited to, alleviation of symptoms; diminishment of the extent of the condition, disorder, or disease; stabilization (i.e., not worsening) of the state of the condition, disorder, or disease; delay in onset or slowing of the progression of the condition, disorder, or disease; amelioration of the condition, disorder, or disease state; and remission (whether partial or total), whether detectable or undetectable, or enhancement or improvement of the condition, disorder, or disease.
- Treatment includes prolonging survival as compared to expected survival if not receiving treatment.
- subject describes an organism, including mammals, to which treatment with the compositions and compounds according to the subject disclosure can be administered.
- Mammalian species that can benefit from the disclosed methods include, but are not limited to, apes, chimpanzees, orangutans, humans, monkeys; and other animals such as dogs, cats, horses, cattle, pigs, sheep, goats, chickens, mice, rats, guinea pigs, and hamsters.
- the subject is a human.
- tissue describes an aggregate of cells typically of a particular kind together with their intercellular substance that form one of the structural materials of a subject.
- organ describes a group of tissues that perform a specific function. For example, heart is a type of organ embodied herein.
- the compounds and pharmaceutically-acceptable salts thereof can be administered by means that produces contact of the active agent with the agent's site of action. They can be administered by conventional means available for use in conjunction with pharmaceuticals in a dosage range of 0.001 to 1000 mg/kg of mammal (e.g. human) body weight per day in a single dose or in divided doses. One dosage range is 0.01 to 500 mg/kg body weight per day orally in a single dose or in divided doses. Administration can be delivered as individual therapeutic agents or in a combination of therapeutic agents. They can be administered alone, but typically are administered with a pharmaceutically acceptable excipient selected on the basis of the chosen route of administration and standard pharmaceutical practice.
- Compounds can be administered by one or more ways.
- the following routes may be utilized: oral, parenteral (including subcutaneous injections, intravenous, intramuscular, intrasternal injection or infusion techniques), inhalation, buccal, sublingual, or rectal, in the form of a unit dosage of a pharmaceutical composition containing an effective amount of the compound and optionally in combination with one or more pharmaceutically-acceptable excipients such as stabilizers, anti-oxidants, lubricants, bulking agents, fillers, carriers, adjuvants, vehicles, diluents and other readily known excipients in standard pharmaceutical practice.
- excipients such as stabilizers, anti-oxidants, lubricants, bulking agents, fillers, carriers, adjuvants, vehicles, diluents and other readily known excipients in standard pharmaceutical practice.
- Liquid preparations suitable for oral administration can employ media such as water, glycols, oils, alcohols, and the like.
- Solid preparations suitable for oral administration e.g. powders, pills, capsules and tablets
- solid excipients such as starches, sugars, kaolin, lubricants, binders, disintegrating agents, antioxidants and the like.
- compositions typically employ sterile water as a carrier and optionally other ingredients, such as solubility aids.
- injectable solutions can be prepared, for example, using a carrier comprising a saline solution, a glucose solution or a solution containing a mixture of saline and glucose. Further guidance for methods suitable for use in preparing pharmaceutical compositions is provided in Remington: The Science and Practice of Pharmacy, 21 st edition (Lippincott Williams & Wilkins, 2006).
- Therapeutic compounds can be administered orally in a dosage range of about 0.001 to 1000 mg/kg of mammal (e.g. human) body weight per day in a single dose or in divided doses.
- One dosage range is about 0.01 to 500 mg/kg body weight per day orally in a single dose or in divided doses.
- the compositions can be provided in the form of tablets or capsules containing about 1.0 to 500 mg of the active ingredient, particularly about 1, 5, 10, 15, 20, 25, 50, 75, 100, 150, 200, 250, 300, 400, 500, and 750 mg of the active ingredient for the symptomatic adjustment of the dosage to the patient to be treated.
- the specific dose level and frequency of dosage for any particular patient may be varied and will depend upon a variety of factors including the activity of the specific compound employed, the metabolic stability and length of action of that compound, the age, body weight, general health, sex, diet, mode and time of administration, rate of excretion, drug combination, the severity of the particular condition, and the subject undergoing therapy.
- the dose frequency can range from multiple doses daily to monthly dosages.
- the preferred dose frequency ranges from twice a day to every two weeks.
- a more preferred dose frequency ranges from twice a day to weekly.
- a most preferred dose frequency ranges from twice a day to twice a week.
- compositions including the active agent can be administered to a subject in an “effective amount.”
- An effective amount may be any amount that provides a beneficial effect to the patient, and in particular embodiments, the effective amount is an amount that may: (1) prevent or reduce rejection of heart tissue allografts and (2) prevent or reduce rejection of a transplanted heart.
- compositions containing the compounds of the invention and a suitable carrier can be in various forms including, but not limited to, solids, solutions, powders, fluid emulsions, fluid suspensions, semi-solids, and dry powders including an effective amount of an the active agent of the invention.
- the active ingredients can be contained in such formulations with pharmaceutically acceptable diluents, fillers, disintegrants, binders, lubricants, surfactants, hydrophobic vehicles, water soluble vehicles, emulsifiers, buffers, humectants, moisturizers, solubilizers, antioxidants, preservatives and the like.
- the means and methods for administration are known in the art and an artisan can refer to various pharmacologic references for guidance.
- the active agent prepared as described above which are formulated as a solid dosage form for oral administration including capsules, tablets, pills, powders, and granules.
- the active compound may be admixed with one or more inert diluent such as sucrose, lactose, or starch.
- Such dosage forms may also comprise, as in normal practice, additional substances other than inert diluents, e.g., lubricating agents such as magnesium stearate.
- the dosage forms may also comprise buffering agents and can additionally be prepared with enteric coatings.
- an oily preparation of an active agent prepared as described above may be lyophilized to form a solid that may be mixed with one or more pharmaceutically acceptable excipient, carrier or diluent to form a tablet, and in yet another embodiment, the active agent may be crystallized to from a solid which may be combined with a pharmaceutically acceptable excipient, carrier or diluent to form a tablet.
- a liquid dosage may include a pharmaceutically acceptable emulsion, solution, suspension, syrup, and elixir containing inert diluents commonly used in the art, such as water.
- Such compositions may also comprise adjuvants, such as wetting agents, emulsifying and suspending agents, and sweetening, flavoring, and perfuming agents.
- the compounds can be formulated with suitable polymeric or hydrophobic materials (for example, as an emulsion in an acceptable oil) or ion exchange resins, or as sparingly soluble derivatives, for example, as a sparingly soluble salt.
- suitable diluents include, but are not limited to those described below:
- Vegetable oil refers to a compound, or mixture of compounds, formed from ethoxylation of vegetable oil, wherein at least one chain of polyethylene glycol is covalently bound to the vegetable oil.
- the fatty acids may have between about twelve carbons to about eighteen carbons.
- the amount of ethoxylation can vary from about 2 to about 200, about 5 to 100, about 10 to about 80, about 20 to about 60, or about 12 to about 18 of ethylene glycol repeat units.
- the vegetable oil may be hydrogenated or unhydrogenated.
- Suitable vegetable oils include, but are not limited to castor oil, hydrogenated castor oil, sesame oil, corn oil, peanut oil, olive oil, sunflower oil, safflower oil, soybean oil, benzyl benzoate, sesame oil, cottonseed oil, and palm oil.
- Suitable vegetable oils include commercially available synthetic oils such as, but not limited to, MiglyolTM 810 and 812 (available from Dynamit Nobel Chemicals, Sweden) NeobeeTM M5 (available from Drew Chemical Corp.), AlofineTM (available from Jarchem Industries), the LubritabTM series (available from JRS Pharma), the SterotexTM (available from Abitec Corp.), SoftisanTM 154 (available from Sasol), CroduretTM (available from Croda), FancolTM (available from the Fanning Corp.), CutinaTM HR (available from Cognis), SimulsolTM (available from CJ Petrow), EmConTM CO (available from Amisol Co.), LipvolTM CO, SES, and HS-K (available from Lipo), and SterotexTM HM (available from Abitec Corp.).
- synthetic oils such as, but not limited to, MiglyolTM 810 and 812 (available from Dynamit Nobel Chemicals, Sweden) NeobeeTM M5 (available from Drew Chemical Corp.), AlofineTM (available
- Suitable vegetable oils including sesame, castor, corn, and cottonseed oils, include those listed in R. C. Rowe and P. J. Shesky, Handbook of Pharmaceutical Excipients , (2006), 5th ed., which is incorporated herein by reference in its entirety.
- Suitable polyethoxylated vegetable oils include but are not limited to, CremaphorTM EL or RH series (available from BASF), EmulphorTM EL-719 (available from Stepan products), and EmulphorTM EL-620P (available from GAF).
- Mineral oils refers to both unrefined and refined (light) mineral oil. Suitable mineral oils include, but are not limited to, the AvatechTM grades (available from Avatar Corp.), DrakeolTM grades (available from Penreco), SiriusTM grades (available from Shell), and the CitationTM grades (available from Avater Corp.).
- Castor oils refers to a compound formed from the ethoxylation of castor oil, wherein at least one chain of polyethylene glycol is covalently bound to the castor oil.
- the castor oil may be hydrogenated or unhydrogenated.
- Synonyms for polyethoxylated castor oil include, but are not limited to polyoxyl castor oil, hydrogenated polyoxyl castor oil, mcrogolglyceroli ricinoleas, macrogolglyceroli hydroxystearas, polyoxyl 35 castor oil, and polyoxyl 40 hydrogenated castor oil.
- Suitable polyethoxylated castor oils include, but are not limited to, the NikkolTM HCO series (available from Nikko Chemicals Co.
- Nikkol HCO-30, HC-40, HC-50, and HC-60 polyethylene glycol-30 hydrogenated castor oil, polyethylene glycol-40 hydrogenated castor oil, polyethylene glycol-50 hydrogenated castor oil, and polyethylene glycol-60 hydrogenated castor oil
- EmulphorTM EL-719 castor oil 40 mole-ethoxylate, available from Stepan Products
- CremophoreTM series available from BASF
- Cremophore RH40, RH60, and EL35 polyethylene glycol-40 hydrogenated castor oil, polyethylene glycol-60 hydrogenated castor oil, and polyethylene glycol-35 hydrogenated castor oil, respectively
- Emulgin® RO and HRE series available from Cognis PharmaLine.
- Other suitable polyoxyethylene castor oil derivatives include those listed in R. C. Rowe and P. J. Shesky, Handbook of Pharmaceutical Excipients , (2006), 5th ed., which is incorporated herein by reference in its entirety.
- Sterol refers to a compound, or mixture of compounds, derived from the ethoxylation of sterol molecule.
- Suitable polyethoyxlated sterols include, but are not limited to, PEG-24 cholesterol ether, SolulanTM C-24 (available from Amerchol); PEG-30 cholestanol, NikkolTM DHC (available from Nikko); Phytosterol, GENEROLTM series (available from Henkel); PEG-25 phyto sterol, NikkolTM BPSH-25 (available from Nikko); PEG-5 soya sterol, NikkolTM BPS-5 (available from Nikko); PEG-10 soya sterol, NikkolTM BPS-10 (available from Nikko); PEG-20 soya sterol, NikkolTM BPS-20 (available from Nikko); and PEG-30 soya sterol, NikkolTM BPS-30 (available from Nikko).
- Polyethylene glycol As used herein, the term “polyethylene glycol” or “PEG” refers to a polymer containing ethylene glycol monomer units of formula —O—CH 2 —CH 2 —. Suitable polyethylene glycols may have a free hydroxyl group at each end of the polymer molecule, or may have one or more hydroxyl groups etherified with a lower alkyl, e.g., a methyl group. Also suitable are derivatives of polyethylene glycols having esterifiable carboxy groups. Polyethylene glycols useful in the present invention can be polymers of any chain length or molecular weight, and can include branching. In some embodiments, the average molecular weight of the polyethylene glycol is from about 200 to about 9000.
- the average molecular weight of the polyethylene glycol is from about 200 to about 5000. In some embodiments, the average molecular weight of the polyethylene glycol is from about 200 to about 900. In some embodiments, the average molecular weight of the polyethylene glycol is about 400.
- Suitable polyethylene glycols include, but are not limited to polyethylene glycol-200, polyethylene glycol-300, polyethylene glycol-400, polyethylene glycol-600, and polyethylene glycol-900. The number following the dash in the name refers to the average molecular weight of the polymer. In some embodiments, the polyethylene glycol is polyethylene glycol-400.
- Suitable polyethylene glycols include, but are not limited to the CarbowaxTM and CarbowaxTM Sentry series (available from Dow), the LipoxolTM series (available from Brenntag), the LutrolTM series (available from BASF), and the PluriolTM series (available from BASF).
- Propylene glycol fatty acid ester refers to a monoether or diester, or mixtures thereof, formed between propylene glycol or polypropylene glycol and a fatty acid.
- Fatty acids that are useful for deriving propylene glycol fatty alcohol ethers include, but are not limited to, those defined herein.
- the monoester or diester is derived from propylene glycol.
- the monoester or diester has about 1 to about 200 oxypropylene units.
- the polypropylene glycol portion of the molecule has about 2 to about 100 oxypropylene units.
- the monoester or diester has about 4 to about 50 oxypropylene units. In some embodiments, the monoester or diester has about 4 to about 30 oxypropylene units.
- Suitable propylene glycol fatty acid esters include, but are not limited to, propylene glycol laurates: LauroglycolTM FCC and 90 (available from Gattefosse); propylene glycol caprylates: CapryolTM PGMC and 90 (available from Gatefosse); and propylene glycol dicaprylocaprates: LabrafacTM PG (available from Gatefosse).
- Stearoyl macrogol glyceride refers to a polyglycolized glyceride synthesized predominately from stearic acid or from compounds derived predominately from stearic acid, although other fatty acids or compounds derived from other fatty acids may be used in the synthesis as well.
- Suitable stearoyl macrogol glycerides include, but are not limited to, Gelucire® 50/13 (available from Gattefossé).
- the diluent component comprises one or more of mannitol, lactose, sucrose, maltodextrin, sorbitol, xylitol, powdered cellulose, microcrystalline cellulose, carboxymethylcellulose, carboxyethylcellulose, methylcellulose, ethylcellulose, hydroxyethylcellulose, methylhydroxyethylcellulose, starch, sodium starch glycolate, pregelatinized starch, a calcium phosphate, a metal carbonate, a metal oxide, or a metal aluminosilicate.
- excipients or carriers for use in solid and/or liquid dosage forms include, but are not limited to:
- Sorbitol Suitable sorbitols include, but are not limited to, PharmSorbidex E420 (available from Cargill), Liponic 70-NC and 76-NC (available from Lipo Chemical), Neosorb (available from Roquette), Partech SI (available from Merck), and Sorbogem (available from SPI Polyols).
- Starch, sodium starch glycolate, and pregelatinized starch include, but are not limited to, those described in R. C. Rowe and P. J. Shesky, Handbook of Pharmaceutical Excipients , (2006), 5th ed., which is incorporated herein by reference in its entirety.
- the disintegrant may include one or more of croscarmellose sodium, carmellose calcium, crospovidone, alginic acid, sodium alginate, potassium alginate, calcium alginate, an ion exchange resin, an effervescent system based on food acids and an alkaline carbonate component, clay, talc, starch, pregelatinized starch, sodium starch glycolate, cellulose floc, carboxymethylcellulose, hydroxypropylcellulose, calcium silicate, a metal carbonate, sodium bicarbonate, calcium citrate, or calcium phosphate.
- croscarmellose sodium, carmellose calcium, crospovidone alginic acid, sodium alginate, potassium alginate, calcium alginate, an ion exchange resin, an effervescent system based on food acids and an alkaline carbonate component, clay, talc, starch, pregelatinized starch, sodium starch glycolate, cellulose floc, carboxymethylcellulose, hydroxypropylcellulose, calcium silicate,
- Still further embodiments of the invention include the active agent administered in combination with other active such as, for example, adjuvants, or other compatible drugs or compounds where such combination is seen to be desirable or advantageous in achieving the desired effects of the methods described herein.
- compositions comprising an effective amount of the active agent and one or more pharmaceutically acceptable excipient.
- pharmaceutical compositions include a pharmaceutical composition comprising an effective amount of pharmaceutically-acceptable salts of the active agent.
- pharmaceutical composition comprising an effective amount of pharmaceutically-acceptable salts of active agent and a pharmaceutically-acceptable excipient.
- the active agent may be administered simultaneously or separately with one or more secondary therapeutic agents.
- Secondary therapeutic agents may include but are not limited to: immunosuppressant agents such as calcineurin inhibitors (cyclosporin, tacrolimus), corticosteroids (methylprednisolone, dexamethasone, prednisolone), cytotoxic immunosuppressants (azathioprine, chlorambucil, cyclophosphamide, mercaptopurine, methotrexate), immunosuppressant antibodies (eg antithymocyte globulins, basiliximab, infliximab), sirolimus derivatives (everolimus, sirolimus), other immunosuppressants (mycophenolate), and any combination thereof.
- immunosuppressant agents such as calcineurin inhibitors (cyclosporin, tacrolimus), corticosteroids (methylprednisolone, dexamethasone, prednisolone), cytotoxic immunos
- the compound of Formula I and pharmaceutical compositions thereof as described herein may be administered to subjects to treat tissue allograft rejection. In other embodiments, the compound of Formula I and pharmaceutical compositions thereof as described herein may be administered to subjects to prevent or reduce rejection of a transplanted organ. In some embodiments the compound of Formula I and pharmaceutical compositions thereof as described herein may be administered to subjects to prevent or reduce rejection of a transplanted heart. In some embodiments, the compound of Formula I and pharmaceutical compositions thereof as described herein may be used to prolong the survival of a transplanted heart.
- NLRP3 inflammasome activation is a mechanism that mediates the rejection of allotransplantation and in one embodiment of the described invention, it is a possible therapeutic target to treat allotransplantation of a heart.
- SANA in vivo, inhibits NF- ⁇ B and the NLRP3 inflammasome-dependent IL-1 ⁇ release.
- C57BL/6 mice were treated with SANA or salicylic acid (SA) (100 mg/kg, IP) or the vehicle (DMSO) for 1 hour. Then were injected with LPS (10 mg/kg, IP) or PBS for 2 hours, with subsequent peritoneal washes and blood extractions.
- SA salicylic acid
- DMSO vehicle
- FIG. 3 demonstrated SANA in a rat model, for a fully mismatched heterotopic heart allograft, prolonged the heart grafted survival respect to the control and its precursor drug.
- Rats were administrated with SANA or SA (100 mg/kg), SANA (50 mg/kg) or vehicle (Phosphate buffer) by oral gavage every day since day ⁇ 1 until day 15 post-transplantation.
- Heart heterotopic transplantation was done by implantation of the donor heart (Lewis 1W rat) into the receptor abdomen (Lewis 1A rat). Rejection was diagnosed when the heart lost functionality (beats has stopped).
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Abstract
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US16/256,235 US10632132B2 (en) | 2018-01-24 | 2019-01-24 | Methods for treating heart transplant rejection |
US16/822,657 US20200215083A1 (en) | 2018-01-24 | 2020-03-18 | Methods for Treating Heart Transplant Rejection |
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US201862621228P | 2018-01-24 | 2018-01-24 | |
US16/256,235 US10632132B2 (en) | 2018-01-24 | 2019-01-24 | Methods for treating heart transplant rejection |
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US16/822,657 Continuation US20200215083A1 (en) | 2018-01-24 | 2020-03-18 | Methods for Treating Heart Transplant Rejection |
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Title |
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Shaw. Comparison of the effects of acetylsalicylic acid and sodium salicylate on prolongation of rat cardiac allograft survival and on inhibition of rat platelet aggregation. Transplantation, vol. 36, No. 1, 1983. * |
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