US10596212B2 - Mangifera indica as a Sirtuin 1 activating agent - Google Patents
Mangifera indica as a Sirtuin 1 activating agent Download PDFInfo
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- US10596212B2 US10596212B2 US15/304,272 US201515304272A US10596212B2 US 10596212 B2 US10596212 B2 US 10596212B2 US 201515304272 A US201515304272 A US 201515304272A US 10596212 B2 US10596212 B2 US 10596212B2
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- indica fruit
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- mangifera
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- 108010041191 Sirtuin 1 Proteins 0.000 title claims abstract description 107
- 235000014826 Mangifera indica Nutrition 0.000 title claims abstract description 98
- 230000003213 activating effect Effects 0.000 title claims abstract description 22
- 240000007228 Mangifera indica Species 0.000 title claims description 122
- 102000000344 Sirtuin 1 Human genes 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 claims abstract description 99
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- 230000032683 aging Effects 0.000 claims description 43
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
Description
b) Preparation of the raw plant material is done immediately after harvest, preferably comprising the washing of the fruits after harvest with pure water, removing the water from the whole fruits and cutting the fruits into slices followed by drying either in the sun or by drying using a flat-bed dryer, a belt dryer, a solar dryer, a hot-air cabinet or a vacuum oven dryer. Consequently, the slices are treated to reduce microbiological load resulting in total aerobic plate count to be lower than 10.000 cfu/g; yeast, mold and coliforms/enterobacteria to be lower than 100 cfu/g; salmonella, Escherichia coli and Staphylococcus aureus to be absent in 1 g. Subsequently, the slices are milled to a particle size of preferably >80% of <2 cm; more preferably to a particle size of >85% of <5 mm and most preferably >95% of <160 μm.
d) The extract is defined by a raw material: extract ratio of 1-200:1, preferably of 2-40:1, most preferably 3-6:1.
TABLE 1 |
Samples for SIRT1 activation assay |
Samples | Assay concentrations (μg/mL) | Solvent (final) |
Batch 1 | 14.3, 35.7, 71.4, 143 | Assay buffer |
Batch 2 | 14.3, 35.7, 71.4, 143 | Assay buffer |
Batch 3 | 14.3, 35.7, 71.4, 143 | Assay buffer |
SIRT1 Assay
TABLE 2 |
Samples for phytochemical investigation |
Samples | Dry matter content % | Extraction solvent |
Batch 1 | 21.1 | water |
Batch 2 | 20.7 | water |
Batch 3 | 19.0 | water |
3. Results
TABLE 3 |
Content of different compounds (%) in Mango fruit powder aqueous |
sample preparation |
Mangiferin | Gallic acid in | Flavonoids* | |
Samples | [%] | [%] | [%] |
Batch 1 | 0.041 | 0.6 | 0.02 |
Batch 2 | 0.038 | 0.8 | 0.044 |
Batch 3 | 0.069 | 0.9 | 0.04 |
*Calculated as rutoside |
4. Summary
Sample | Assay concentrations (μg/mL) | Solvent (final) |
Batch 1 | 0.25; 0.5; 1.0 mg/ml | water |
Assay | ||||
concentrations | Solvent | |||
Sample | (μg/mL) | (final) | ||
Batch 1 | 0.25, 0.5, | water | ||
1.0, 2.0 μg/ml | ||||
4. Assay Performance
Alpha-Glucosidase Assay
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