UA99899C2 - Bi-aryl meta-pyrimidine inhibitors of kinases - Google Patents

Bi-aryl meta-pyrimidine inhibitors of kinases

Info

Publication number
UA99899C2
UA99899C2 UAA200807479A UAA200807479A UA99899C2 UA 99899 C2 UA99899 C2 UA 99899C2 UA A200807479 A UAA200807479 A UA A200807479A UA A200807479 A UAA200807479 A UA A200807479A UA 99899 C2 UA99899 C2 UA 99899C2
Authority
UA
Ukraine
Prior art keywords
kinases
meta
pyrimidine inhibitors
aryl meta
pyrimidine
Prior art date
Application number
UAA200807479A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Жиангуо КАО
Джон ХУД
Даниэль Лохс
Чи Чинг МАК
ФЕРСОН Эндрю МАК
Гленн НОРОНА
Вед Петек
Джоэл РЕНИК
Ричард М. Солл
Бинки ЗЕНГ
Original Assignee
Таргеджен, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Таргеджен, Инк. filed Critical Таргеджен, Инк.
Publication of UA99899C2 publication Critical patent/UA99899C2/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non receptor kinases.
UAA200807479A 2005-11-01 2006-10-26 Bi-aryl meta-pyrimidine inhibitors of kinases UA99899C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73262905P 2005-11-01 2005-11-01

Publications (1)

Publication Number Publication Date
UA99899C2 true UA99899C2 (en) 2012-10-25

Family

ID=40413957

Family Applications (3)

Application Number Title Priority Date Filing Date
UAA200807479A UA99899C2 (en) 2005-11-01 2006-10-26 Bi-aryl meta-pyrimidine inhibitors of kinases
UAA201203128A UA109412C2 (en) 2005-11-01 2006-10-26 5-METHYL-N2- [4- (4-METHYLPIPERAZIN-1-yl) PHENYL] -PYRIMIDINE-2,4-DIAMINE AND ITS APPLICATION IN THE METHOD OF PREPARATION
UAA201203127A UA109411C2 (en) 2005-11-01 2006-10-26 N-TERT-BUTYL-3- (2-CHLORO-5-METHYLPYRIMIDIN-4-YLAMINO) BENZOLSULPHONAMIDE AND ITS APPLICATION IN THE METHOD OF PREPARATION OF THE COMPOUND

Family Applications After (2)

Application Number Title Priority Date Filing Date
UAA201203128A UA109412C2 (en) 2005-11-01 2006-10-26 5-METHYL-N2- [4- (4-METHYLPIPERAZIN-1-yl) PHENYL] -PYRIMIDINE-2,4-DIAMINE AND ITS APPLICATION IN THE METHOD OF PREPARATION
UAA201203127A UA109411C2 (en) 2005-11-01 2006-10-26 N-TERT-BUTYL-3- (2-CHLORO-5-METHYLPYRIMIDIN-4-YLAMINO) BENZOLSULPHONAMIDE AND ITS APPLICATION IN THE METHOD OF PREPARATION OF THE COMPOUND

Country Status (3)

Country Link
CN (1) CN101370792B (en)
UA (3) UA99899C2 (en)
ZA (1) ZA200804083B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013517273A (en) * 2010-01-13 2013-05-16 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Compounds and methods
CA2816957A1 (en) * 2010-11-07 2012-05-10 Targegen, Inc. Compositions and methods for treating myelofibrosis
CN103242240B (en) * 2012-02-10 2016-01-06 上海温康化学研发有限公司 A kind of intermediate, its salt and preparation method thereof of sulfamide compound
CN105796562A (en) * 2012-09-10 2016-07-27 杨子娇 Application of compound to preparation of drug for preventing and treating glaucoma
CN103664798A (en) * 2012-09-20 2014-03-26 杨育新 Compounds for treating traumatic brain injury diseases and application thereof
CN103664799A (en) * 2012-09-25 2014-03-26 杨子娇 Compounds for treating narrow chamber angle and application thereof
CN103664907A (en) * 2012-09-25 2014-03-26 杨子娇 Compounds for treating narrow chamber angle and application thereof
CN103724331A (en) * 2012-10-11 2014-04-16 韩冰 Compound for treating cerebral palsy and use thereof
DK2970205T3 (en) * 2013-03-14 2019-07-29 Tolero Pharmaceuticals Inc JAK2 and ALK2 inhibitors and methods for their use
TWI675833B (en) * 2013-12-11 2019-11-01 美商百健Ｍａ公司 Biaryl inhibitors of bruton's tyrosine kinase
CN103992262B (en) * 2014-06-12 2015-11-11 苏州明锐医药科技有限公司 Sai Rui replaces the preparation method of Buddhist nun and intermediate thereof
CN106188063A (en) * 2015-05-08 2016-12-07 中国科学院上海药物研究所 As Lp-PLA2dicyclo compounds, its preparation method and the medical usage of inhibitor
CN108689949A (en) * 2018-07-02 2018-10-23 湖南华腾制药有限公司 A kind of pyridine derivatives and preparation method thereof
CN110305140B (en) 2019-07-30 2020-08-04 上海勋和医药科技有限公司 Dihydropyrrolopyrimidines selective JAK2 inhibitors
WO2021057882A1 (en) * 2019-09-26 2021-04-01 贝达药业股份有限公司 Egfr inhibitor, composition and preparation method therefor
US20240108633A1 (en) * 2020-12-29 2024-04-04 Onquality Pharmaceuticals China Ltd. Method for preventing or treating disease or condition associated with antitumor agent
EP4279486A1 (en) * 2021-01-11 2023-11-22 Guangzhou Salustier Biosciences Co., Ltd. 2-aminopyrimidine compound and pharmaceutical composition thereof and application thereof
CN112920124B (en) * 2021-01-29 2024-03-01 安徽医科大学 Pyrimidine-2, 4-diamine compound, and preparation method and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0004887D0 (en) * 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds

Also Published As

Publication number Publication date
CN101370792B (en) 2013-03-20
CN101370792A (en) 2009-02-18
ZA200804083B (en) 2009-09-30
UA109411C2 (en) 2015-08-25
UA109412C2 (en) 2015-08-25

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