UA99019C2 - Method for determination of doxazosin by gas-liquid chromatography - Google Patents
Method for determination of doxazosin by gas-liquid chromatographyInfo
- Publication number
- UA99019C2 UA99019C2 UAA201013841A UAA201013841A UA99019C2 UA 99019 C2 UA99019 C2 UA 99019C2 UA A201013841 A UAA201013841 A UA A201013841A UA A201013841 A UAA201013841 A UA A201013841A UA 99019 C2 UA99019 C2 UA 99019C2
- Authority
- UA
- Ukraine
- Prior art keywords
- doxazosin
- determination
- gas
- temperature
- rate
- Prior art date
Links
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- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
The invention relates to analytical chemistry, in particular to methods for determination of doxazosin by gas-liquid chromatography, and can be used for determination of this substance in pharmaceutical analysis and at chemical-toxicological investigations. The object of the invention is in development of new method for the determination of doxazosin by gas-liquid chromatography, this through selection of optimal temperature program and balanced fixed liquid phase together with the other parameters of the process prevents destruction and provides reliable, accurate determination of doxazosin in samples of water solution with concentration 1.25-10.0 μg/ml. The method claimed is realized as follows. The determination of doxazosin is carried out with use of gas chromatograph "Agilent 19091 J-413", capillary column 30m x 320 μm with fixed liquid phase - 5%-phenyl-95%-dimethyl-polysiloxane, HP-5 0.25 mkm; movable phase – gas-carrier – helium, this is supplied to the column at rate of 45.0 ml/min. The detection of substance is carried out by flame-ionization detector, rate of hydrogen supply is 40,0 ml/min. Temperature of the column is linearly programmed: 2 min at 180 °C; temperature increase from 180 to 220 °C at rate 10 °C per minute during 4 min.; at 220 °C temperature mode is kept for 2 minutes. Temperature of evaporator is 250 °C, detector - 250 °C. Quantitative content of doxazosin is determined by method of absolute calibration by peak area.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAA201013841A UA99019C2 (en) | 2010-11-22 | 2010-11-22 | Method for determination of doxazosin by gas-liquid chromatography |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAA201013841A UA99019C2 (en) | 2010-11-22 | 2010-11-22 | Method for determination of doxazosin by gas-liquid chromatography |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA99019C2 true UA99019C2 (en) | 2012-07-10 |
Family
ID=50848049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201013841A UA99019C2 (en) | 2010-11-22 | 2010-11-22 | Method for determination of doxazosin by gas-liquid chromatography |
Country Status (1)
| Country | Link |
|---|---|
| UA (1) | UA99019C2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114414715A (en) * | 2022-01-26 | 2022-04-29 | 武汉九州钰民医药科技有限公司 | Detection method and application of benzene in ceftazidime residual solvent |
-
2010
- 2010-11-22 UA UAA201013841A patent/UA99019C2/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114414715A (en) * | 2022-01-26 | 2022-04-29 | 武汉九州钰民医药科技有限公司 | Detection method and application of benzene in ceftazidime residual solvent |
| CN114414715B (en) * | 2022-01-26 | 2024-04-26 | 武汉九州钰民医药科技有限公司 | Method for detecting benzene in ceftazidime residual solvent and application |
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