UA98775C2 - Enantiomerically pure phosphoindoles as hiv inhibitors - Google Patents

Enantiomerically pure phosphoindoles as hiv inhibitors

Info

Publication number
UA98775C2
UA98775C2 UAA200902887A UAA200902887A UA98775C2 UA 98775 C2 UA98775 C2 UA 98775C2 UA A200902887 A UAA200902887 A UA A200902887A UA A200902887 A UAA200902887 A UA A200902887A UA 98775 C2 UA98775 C2 UA 98775C2
Authority
UA
Ukraine
Prior art keywords
hydrogen
nrr
heterocyclyl
alkynyl
alkenyl
Prior art date
Application number
UAA200902887A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Річард Сторер
Франсуа-Рене Александер
Сіріл Дуссон
Адель М. Мусса
Едвард Бріджес
Original Assignee
Айденікс Фармасутікалз, Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Айденікс Фармасутікалз, Інк. filed Critical Айденікс Фармасутікалз, Інк.
Publication of UA98775C2 publication Critical patent/UA98775C2/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

3-Phosphoindole compounds substantially in the form of a single enantiomer useful for the treatment of Flaviviridae virus infections, and particularly for HLV infections are provided. Also provided are pharmaceutical compositions comprising the 3-phosphoindole compounds alone or in combination with one or more other antiviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds. The 3-phosphoindole compounds are of the formula (A) or (B) and the pharmaceutically acceptable salts, solvates, hydrates, or esters thereof. In the formulae X is hydrogen; aryl or heterocyclyl; C2-6 alkenyl, C2-6 alkynyl oralkyl; Y is hydrogen, -R, -O-R, -NH-R, or -NRR; Z is -OR, -NHR, -NRR, carboxamido, amido, carboxyl, carbonyl, or an amino acid residue; R1 is hydrogen, acyl, -S(O)n-R, carboxyl, carbonyl, or an amino acid residue; each R , R , R and R is independently hydrogen, C2-6 alkenyl, C2-6 alkynyl, aryl, heterocyclyl, halogen, -CN, -CF3, -OR, -NHR, -NRR, or -NO2; n is 0, 1, or 2; and each R is independently hydrogen, alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, or heterocyclyl.
UAA200902887A 2006-09-29 2007-09-28 Enantiomerically pure phosphoindoles as hiv inhibitors UA98775C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84858406P 2006-09-29 2006-09-29

Publications (1)

Publication Number Publication Date
UA98775C2 true UA98775C2 (en) 2012-06-25

Family

ID=41522314

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200902887A UA98775C2 (en) 2006-09-29 2007-09-28 Enantiomerically pure phosphoindoles as hiv inhibitors

Country Status (3)

Country Link
CN (1) CN101627044A (en)
UA (1) UA98775C2 (en)
ZA (1) ZA200902172B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103275126B (en) * 2013-05-28 2016-03-23 兰州大学 The method of the phosphonylation indoles in a kind of stereoselective syntheses 3-position
KR102348158B1 (en) * 2018-07-12 2022-01-10 한국생명공학연구원 Substrate for Nucleic Acid Amplification and Method for Manufacturing Thereof

Also Published As

Publication number Publication date
CN101627044A (en) 2010-01-13
ZA200902172B (en) 2010-06-30

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