UA98775C2 - Enantiomerically pure phosphoindoles as hiv inhibitors - Google Patents
Enantiomerically pure phosphoindoles as hiv inhibitorsInfo
- Publication number
- UA98775C2 UA98775C2 UAA200902887A UAA200902887A UA98775C2 UA 98775 C2 UA98775 C2 UA 98775C2 UA A200902887 A UAA200902887 A UA A200902887A UA A200902887 A UAA200902887 A UA A200902887A UA 98775 C2 UA98775 C2 UA 98775C2
- Authority
- UA
- Ukraine
- Prior art keywords
- hydrogen
- nrr
- heterocyclyl
- alkynyl
- alkenyl
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
3-Phosphoindole compounds substantially in the form of a single enantiomer useful for the treatment of Flaviviridae virus infections, and particularly for HLV infections are provided. Also provided are pharmaceutical compositions comprising the 3-phosphoindole compounds alone or in combination with one or more other antiviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds. The 3-phosphoindole compounds are of the formula (A) or (B) and the pharmaceutically acceptable salts, solvates, hydrates, or esters thereof. In the formulae X is hydrogen; aryl or heterocyclyl; C2-6 alkenyl, C2-6 alkynyl oralkyl; Y is hydrogen, -R, -O-R, -NH-R, or -NRR; Z is -OR, -NHR, -NRR, carboxamido, amido, carboxyl, carbonyl, or an amino acid residue; R1 is hydrogen, acyl, -S(O)n-R, carboxyl, carbonyl, or an amino acid residue; each R , R , R and R is independently hydrogen, C2-6 alkenyl, C2-6 alkynyl, aryl, heterocyclyl, halogen, -CN, -CF3, -OR, -NHR, -NRR, or -NO2; n is 0, 1, or 2; and each R is independently hydrogen, alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, or heterocyclyl.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84858406P | 2006-09-29 | 2006-09-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA98775C2 true UA98775C2 (en) | 2012-06-25 |
Family
ID=41522314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200902887A UA98775C2 (en) | 2006-09-29 | 2007-09-28 | Enantiomerically pure phosphoindoles as hiv inhibitors |
Country Status (3)
Country | Link |
---|---|
CN (1) | CN101627044A (en) |
UA (1) | UA98775C2 (en) |
ZA (1) | ZA200902172B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103275126B (en) * | 2013-05-28 | 2016-03-23 | 兰州大学 | The method of the phosphonylation indoles in a kind of stereoselective syntheses 3-position |
KR102348158B1 (en) * | 2018-07-12 | 2022-01-10 | 한국생명공학연구원 | Substrate for Nucleic Acid Amplification and Method for Manufacturing Thereof |
-
2007
- 2007-09-28 UA UAA200902887A patent/UA98775C2/en unknown
- 2007-09-28 CN CN200780044249A patent/CN101627044A/en active Pending
-
2009
- 2009-03-27 ZA ZA200902172A patent/ZA200902172B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN101627044A (en) | 2010-01-13 |
ZA200902172B (en) | 2010-06-30 |
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