UA97507C2 - Method for preparing of substituted adamanty-larylmagnesium halides - Google Patents
Method for preparing of substituted adamanty-larylmagnesium halidesInfo
- Publication number
- UA97507C2 UA97507C2 UAA200907979A UAA200907979A UA97507C2 UA 97507 C2 UA97507 C2 UA 97507C2 UA A200907979 A UAA200907979 A UA A200907979A UA A200907979 A UAA200907979 A UA A200907979A UA 97507 C2 UA97507 C2 UA 97507C2
- Authority
- UA
- Ukraine
- Prior art keywords
- substituted
- preparing
- halides
- adamantylarylhalide
- adamantylarylmagnesium
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000004820 halides Chemical class 0.000 title abstract 3
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 abstract 4
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- 229910052786 argon Inorganic materials 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012039 electrophile Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention concerns fine organic synthesis, particularly the method for preparing of substituted adamantylarylmagnesium halides. The known methods for preparing Grignard's reagent from substituted adamantylarylhalide give very low yeld of the desired product. Substituted adatnantylarylhalides are active intermediates that by interacting with various electrophiles provide for a wide range of biologically active compounds. The aim of current invention was to develop a method for preparing substituted adamantylarylmagnesium halides. The aim was attained adding lithium chloride in the Grignard's reagent synthesis by acting on magnesium metal in dry tetrahydrofuran under argon by substituted adamantylarylhalide. It was demonstrated that adding lithium chloride to adamantylarylhalide within a range from 1:1 to 1:2 provides for stable high yield of the desired end product.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LV060151A LV13735B (en) | 2006-12-28 | 2006-12-28 | Method for manufacturing substituted adamantylarylmagnesium chalogenides |
| PCT/EP2007/064648 WO2008080993A2 (en) | 2006-12-28 | 2007-12-28 | A method for preparation of substituted adamantylarylmagnesium halides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA97507C2 true UA97507C2 (en) | 2012-02-27 |
Family
ID=39589040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200907979A UA97507C2 (en) | 2006-12-28 | 2007-12-28 | Method for preparing of substituted adamanty-larylmagnesium halides |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2129679A2 (en) |
| EA (1) | EA015949B1 (en) |
| LV (1) | LV13735B (en) |
| UA (1) | UA97507C2 (en) |
| WO (1) | WO2008080993A2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113866292B (en) * | 2021-09-13 | 2024-03-19 | 河北威远生物化工有限公司 | Method for measuring content of o-chlorobenzyl magnesium chloride |
| CN117511212B (en) * | 2023-11-09 | 2024-04-12 | 东莞市好易达新材料科技有限公司 | High-temperature-resistant silicone glass fiber sleeve and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1456165A1 (en) | 2001-11-30 | 2004-09-15 | The Burnham Institute | Induction of apoptosis in cancer cells |
| EP1582523A1 (en) | 2004-04-02 | 2005-10-05 | Ludwig-Maximilians-Universität München | Method of preparing organomagnesium compounds |
-
2006
- 2006-12-28 LV LV060151A patent/LV13735B/en unknown
-
2007
- 2007-12-28 EP EP07858234A patent/EP2129679A2/en not_active Withdrawn
- 2007-12-28 EA EA200900899A patent/EA015949B1/en not_active IP Right Cessation
- 2007-12-28 UA UAA200907979A patent/UA97507C2/en unknown
- 2007-12-28 WO PCT/EP2007/064648 patent/WO2008080993A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EA200900899A1 (en) | 2010-02-26 |
| EP2129679A2 (en) | 2009-12-09 |
| EA015949B1 (en) | 2011-12-30 |
| LV13735B (en) | 2008-09-20 |
| WO2008080993A3 (en) | 2009-03-12 |
| WO2008080993A2 (en) | 2008-07-10 |
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