UA96783C2 - Substituted methylphenylketones for use as pde4 inhibitors - Google Patents

Substituted methylphenylketones for use as pde4 inhibitors

Info

Publication number
UA96783C2
UA96783C2 UAA200907695A UAA200907695A UA96783C2 UA 96783 C2 UA96783 C2 UA 96783C2 UA A200907695 A UAA200907695 A UA A200907695A UA A200907695 A UAA200907695 A UA A200907695A UA 96783 C2 UA96783 C2 UA 96783C2
Authority
UA
Ukraine
Prior art keywords
compounds
represent
xindependently
hydrogen
haloalkyl
Prior art date
Application number
UAA200907695A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Якоб Фелдинг
Симон Фельдбек НИЛЬСЕН
Original Assignee
Лео Фарма А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лео Фарма А/С filed Critical Лео Фарма А/С
Publication of UA96783C2 publication Critical patent/UA96783C2/en

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  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to a compound according to formula: (T); wherein XX, X, Xand Xindependently of each other represent -CH- or N; or X, Xand Xindependently of each other represent -CH- or N, and Xi and Xindependently of each other represent C and form part of an additional 6-membered aromatic ring; Rrepresents hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, hydroxyalkyl, or alkylcarbonyl, all of which are optionally substituted; Rand Rindependently represent hydrogen, -CH-C(O)KR-R', alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, haloalkyl, hydroxyalkyl, heterocycloalkenyl, alkylaryl, alky-, lalkoxycarbonyl, alkylcarbonyloxy, oralkoxyalkyl, all of which are optionally substituted; Rrepresents hydrogen, halogen, cyano, amino, alkoxy or alkylamino, X-Xrepresent -CH- or N, including N-oxides, enantiomers and diastereomers; and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention relates further to processes for the preparation of said compounds, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.(I)
UAA200907695A 2006-12-22 2007-12-21 Substituted methylphenylketones for use as pde4 inhibitors UA96783C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87168906P 2006-12-22 2006-12-22

Publications (1)

Publication Number Publication Date
UA96783C2 true UA96783C2 (en) 2011-12-12

Family

ID=41484189

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200907695A UA96783C2 (en) 2006-12-22 2007-12-21 Substituted methylphenylketones for use as pde4 inhibitors

Country Status (5)

Country Link
CN (1) CN101611005B (en)
ES (1) ES2363565T3 (en)
SI (1) SI2125736T1 (en)
UA (1) UA96783C2 (en)
ZA (1) ZA200904358B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102775345A (en) * 2011-05-13 2012-11-14 上海特化医药科技有限公司 Preparation method of roflumilast and intermediates
RU2015121043A (en) * 2012-12-05 2017-01-11 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Phenylethylpyridine derivatives as PDE-4 inhibitors
CN110407741B (en) * 2018-04-26 2023-03-21 启元生物(杭州)有限公司 Anti-inflammatory compound and preparation and application thereof
CN109761844B (en) * 2019-01-29 2021-11-09 常州南京大学高新技术研究院 Method for preparing 1- (4-benzoylamino-phenyl) -3-phenylpropane-1, 3-diketone by one-pot method
CN110724108B (en) * 2019-11-18 2023-04-28 上海医药工业研究院有限公司 Esalapril Lin Zhongjian body and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9401460D0 (en) * 1994-01-26 1994-03-23 Rhone Poulenc Rorer Ltd Compositions of matter
WO1998022455A1 (en) * 1996-11-19 1998-05-28 Kyowa Hakko Kogyo Co., Ltd. Oxygenic heterocyclic compounds
WO2006135828A2 (en) * 2005-06-10 2006-12-21 Memory Pharmaceuticals Corporation Trisubstituted amines as phosphodiesterase 4 inhibitors

Also Published As

Publication number Publication date
CN101611005B (en) 2013-11-06
CN101611005A (en) 2009-12-23
ES2363565T3 (en) 2011-08-09
ZA200904358B (en) 2010-08-25
SI2125736T1 (en) 2011-07-29

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