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Publication of UA95966C2publicationCriticalpatent/UA95966C2/en
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
There are disclosed novel 5-substituted 7-amino-[l,3]thiazolo[4,5-d]pyrimidine derivatives of formula (I), (I)wherein R, R, R, Rand n are as defined in the specification, and pharmaceutically acceptable salts thereof, together with processes for their preparation, pharmaceutical compositions comprising them and their use in therapy. The compounds of formula (I) are CX3CR1 receptor antagonists and are thereby particularly useful in the treatment or prophylaxis of neurodegenerative disorders, demyelinating disease, cardio- and cerebrovascular atherosclerotic disorders, peripheral artery disease, rheumatoid arthritis, pulmonary diseases such as COPD, asthma or pain.
UAA200901647A2006-09-292007-09-275,7-disubstituted[1,3]thiazolo[4,5]pyrimidin-2(3h)-amine derivatives and their use in therapy
UA95966C2
(en)
Compounds derived from 3-phenyl-imidazo [1,2-a] pyridines; pharmaceutical composition; process for its preparation, useful as inhibitors of alk-5 or alk-4 in the treatment of inflammatory or obstructive diseases of the respiratory tract, cancer, muscular diseases, skeletal disorders