UA95966C2 - 5,7-disubstituted[1,3]thiazolo[4,5]pyrimidin-2(3h)-amine derivatives and their use in therapy - Google Patents

5,7-disubstituted[1,3]thiazolo[4,5]pyrimidin-2(3h)-amine derivatives and their use in therapy

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Publication number
UA95966C2
UA95966C2 UAA200901647A UAA200901647A UA95966C2 UA 95966 C2 UA95966 C2 UA 95966C2 UA A200901647 A UAA200901647 A UA A200901647A UA A200901647 A UAA200901647 A UA A200901647A UA 95966 C2 UA95966 C2 UA 95966C2
Authority
UA
Ukraine
Prior art keywords
thiazolo
therapy
pyrimidin
disubstituted
formula
Prior art date
Application number
UAA200901647A
Other languages
Russian (ru)
Inventor
Рольф Йоганссон
София Карлстрьом
Гуннар Нордволл
Анника Керс
Тобиас Рейн
Кен Сливо
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of UA95966C2 publication Critical patent/UA95966C2/en

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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

There are disclosed novel 5-substituted 7-amino-[l,3]thiazolo[4,5-d]pyrimidine derivatives of formula (I), (I)wherein R, R, R, Rand n are as defined in the specification, and pharmaceutically acceptable salts thereof, together with processes for their preparation, pharmaceutical compositions comprising them and their use in therapy. The compounds of formula (I) are CX3CR1 receptor antagonists and are thereby particularly useful in the treatment or prophylaxis of neurodegenerative disorders, demyelinating disease, cardio- and cerebrovascular atherosclerotic disorders, peripheral artery disease, rheumatoid arthritis, pulmonary diseases such as COPD, asthma or pain.
UAA200901647A 2006-09-29 2007-09-27 5,7-disubstituted[1,3]thiazolo[4,5]pyrimidin-2(3h)-amine derivatives and their use in therapy UA95966C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82744206P 2006-09-29 2006-09-29

Publications (1)

Publication Number Publication Date
UA95966C2 true UA95966C2 (en) 2011-09-26

Family

ID=50837433

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200901647A UA95966C2 (en) 2006-09-29 2007-09-27 5,7-disubstituted[1,3]thiazolo[4,5]pyrimidin-2(3h)-amine derivatives and their use in therapy

Country Status (1)

Country Link
UA (1) UA95966C2 (en)

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