UA94442C2 - Purification and use of a factor for supporting wound healing - Google Patents
Purification and use of a factor for supporting wound healingInfo
- Publication number
- UA94442C2 UA94442C2 UAA200810618A UAA200810618A UA94442C2 UA 94442 C2 UA94442 C2 UA 94442C2 UA A200810618 A UAA200810618 A UA A200810618A UA A200810618 A UAA200810618 A UA A200810618A UA 94442 C2 UA94442 C2 UA 94442C2
- Authority
- UA
- Ukraine
- Prior art keywords
- growth factor
- factor
- wound healing
- supporting wound
- purification
- Prior art date
Links
- 230000029663 wound healing Effects 0.000 title abstract 3
- 238000000746 purification Methods 0.000 title abstract 2
- 102000004411 Antithrombin III Human genes 0.000 abstract 2
- 108090000935 Antithrombin III Proteins 0.000 abstract 2
- 102000018233 Fibroblast Growth Factor Human genes 0.000 abstract 2
- 108050007372 Fibroblast Growth Factor Proteins 0.000 abstract 2
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 abstract 2
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 abstract 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 2
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 abstract 2
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 abstract 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 2
- 229960005348 antithrombin iii Drugs 0.000 abstract 2
- 229940126864 fibroblast growth factor Drugs 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 2
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 abstract 1
- 102000013275 Somatomedins Human genes 0.000 abstract 1
- 102000006747 Transforming Growth Factor alpha Human genes 0.000 abstract 1
- 102000009618 Transforming Growth Factors Human genes 0.000 abstract 1
- 108010009583 Transforming Growth Factors Proteins 0.000 abstract 1
- 101800004564 Transforming growth factor alpha Proteins 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/49—Platelet-derived growth factor [PDGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A process for manufacturing of a composition containing a purified factor for supporting wound healing selected from the group consisting of hepatocyte growth factor (HGF), platelet derived growth factor (PDGF), epidermal growth factor (EGF), transforming growth factor alfa (TGF-α), transforming growth factor beta (TGF-β), insulin like growth factor (IGF-I) and fibroblast growth factor (FGF) from sources, such as blood, containing the factor for supporting wound healing, wherein the manufacturing process comprises purification steps which are performed in the presence of antithrombin III (AT-III).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06100819 | 2006-01-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA94442C2 true UA94442C2 (en) | 2011-05-10 |
Family
ID=36607451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200810618A UA94442C2 (en) | 2006-01-25 | 2007-01-25 | Purification and use of a factor for supporting wound healing |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8962813B2 (en) |
| EP (1) | EP1987054A1 (en) |
| JP (1) | JP2009524622A (en) |
| KR (1) | KR20080088610A (en) |
| CN (1) | CN101374855A (en) |
| AU (1) | AU2007209363B2 (en) |
| BR (1) | BRPI0707268A2 (en) |
| CA (1) | CA2640010A1 (en) |
| IL (1) | IL192320A0 (en) |
| NO (1) | NO20082787L (en) |
| RU (1) | RU2520817C2 (en) |
| UA (1) | UA94442C2 (en) |
| WO (1) | WO2007085626A1 (en) |
| ZA (1) | ZA200806382B (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7935364B2 (en) * | 2008-03-04 | 2011-05-03 | Wisconsin Alumni Research Foundation | Patterned gradient wound dressing and methods of using same to promote wound healing |
| DE102009029194A1 (en) * | 2009-09-04 | 2011-04-07 | Kimberly-Clark Worldwide, Inc., Neenah | Separation of colored substances from aqueous liquids |
| WO2011028173A1 (en) * | 2009-09-05 | 2011-03-10 | Fariba Nayeri | Method of treatment of a patient suffering from an infection or injuries caused or complicated by infection |
| AU2010202125B1 (en) * | 2010-05-26 | 2010-09-02 | Takeda Pharmaceutical Company Limited | A method to produce an immunoglobulin preparation with improved yield |
| US8796430B2 (en) | 2010-05-26 | 2014-08-05 | Baxter International Inc. | Method to produce an immunoglobulin preparation with improved yield |
| US8772462B2 (en) | 2010-05-26 | 2014-07-08 | Baxter International Inc. | Removal of serine proteases by treatment with finely divided silicon dioxide |
| IL210162A0 (en) * | 2010-12-21 | 2011-03-31 | Omrix Biopharmaceuticals | Viral inactivated platelet extract, use and preparation thereof |
| TR201807926T4 (en) | 2011-02-04 | 2018-06-21 | Octapharma Ag | The method of inactivating / removing coagulation factors by precipitation. |
| WO2013077641A1 (en) * | 2011-11-22 | 2013-05-30 | (주)아모레퍼시픽 | Skin repair enhancer containing growth factors |
| US9161869B2 (en) | 2012-03-30 | 2015-10-20 | Kimberly-Clark Worldwide, Inc. | Absorbent articles with decolorizing agents |
| US9237975B2 (en) | 2013-09-27 | 2016-01-19 | Kimberly-Clark Worldwide, Inc. | Absorbent article with side barriers and decolorizing agents |
| US10239926B2 (en) | 2015-02-27 | 2019-03-26 | The University Of Vermont And State Agriculture College | Compositions and methods for vascular protection against reperfusion injury after myocardial ischemia |
| EP3334441B1 (en) | 2015-08-13 | 2021-06-16 | Kamada Ltd. | Compositions derived from cohn fraction paste and use thereof |
| CN105797205B (en) * | 2016-04-20 | 2018-08-31 | 江苏迈健生物科技发展股份有限公司 | Stem cell culture supernatant gel and preparation method thereof |
| CN107216384A (en) * | 2017-05-11 | 2017-09-29 | 深圳市卫光生物制品股份有限公司 | A kind of method that human plasma transferrins is isolated and purified |
| US10836790B1 (en) * | 2019-09-20 | 2020-11-17 | Plasma Technologies, Llc | Therapeutic protein compositions and methods |
| US20210087224A1 (en) * | 2019-09-20 | 2021-03-25 | Plasma Technologies, Llc | Compositions and methods for generating modified cryo poor plasma |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6045534A (en) * | 1983-08-22 | 1985-03-12 | Otsuka Pharmaceut Co Ltd | Hepatocyte growth factor |
| JPS60243019A (en) * | 1984-05-17 | 1985-12-03 | Mitsubishi Chem Ind Ltd | Hepatic cell proliferation factor |
| US4673733A (en) * | 1985-04-11 | 1987-06-16 | Sudhish Chandra | Treatment of biological and pharmaceutical products adsorbed on a solid phase with virus and pyrogen inactivating agents |
| US4839298A (en) * | 1986-02-14 | 1989-06-13 | Akzo N.V. | Virus inactivating diluents used in immunoassays |
| JP2564486B2 (en) * | 1986-07-14 | 1996-12-18 | 修治 橋本 | Hepatocyte growth factor |
| NZ232813A (en) * | 1989-03-10 | 1992-08-26 | Snow Brand Milk Products Co Ltd | Human fibroblast glycoprotein, cell differentiation, blood vessel endothelial cell growth factor, cellular immunology inforcing factor of 78 or 74 thousand daltons plus or minus two thousand daltons |
| GB9110202D0 (en) * | 1991-05-10 | 1991-07-03 | Erba Carlo Spa | Truncated forms of the hepatocyte growth factor(hgf)receptor |
| US5348941A (en) * | 1992-04-01 | 1994-09-20 | Merck & Co., Inc. | Stabilizers for fibroblast growth factors |
| AUPN858596A0 (en) * | 1996-03-08 | 1996-04-04 | Csl Limited | Filtration of plasma precipitates using cellulose filter aid |
| SE0000178D0 (en) * | 2000-01-21 | 2000-01-21 | Pharmacia & Upjohn Ab | Protein purification I |
| US6451978B2 (en) * | 2000-01-21 | 2002-09-17 | Biovitrum Ab | Purification of antithrombin-III-α and β |
| AU2006259408A1 (en) * | 2005-06-17 | 2006-12-28 | Genentech, Inc. | Use of VEGF for wound healing |
-
2007
- 2007-01-25 EP EP07726226A patent/EP1987054A1/en not_active Withdrawn
- 2007-01-25 JP JP2008551784A patent/JP2009524622A/en active Pending
- 2007-01-25 AU AU2007209363A patent/AU2007209363B2/en not_active Ceased
- 2007-01-25 KR KR1020087018153A patent/KR20080088610A/en not_active Application Discontinuation
- 2007-01-25 US US12/162,107 patent/US8962813B2/en not_active Expired - Fee Related
- 2007-01-25 CN CNA2007800029120A patent/CN101374855A/en active Pending
- 2007-01-25 WO PCT/EP2007/050714 patent/WO2007085626A1/en active Application Filing
- 2007-01-25 UA UAA200810618A patent/UA94442C2/en unknown
- 2007-01-25 CA CA002640010A patent/CA2640010A1/en not_active Abandoned
- 2007-01-25 RU RU2008134479/10A patent/RU2520817C2/en not_active IP Right Cessation
- 2007-01-25 BR BRPI0707268-6A patent/BRPI0707268A2/en not_active IP Right Cessation
-
2008
- 2008-06-19 IL IL192320A patent/IL192320A0/en unknown
- 2008-06-20 NO NO20082787A patent/NO20082787L/en not_active Application Discontinuation
- 2008-07-23 ZA ZA200806382A patent/ZA200806382B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US8962813B2 (en) | 2015-02-24 |
| BRPI0707268A2 (en) | 2011-04-26 |
| CN101374855A (en) | 2009-02-25 |
| AU2007209363A1 (en) | 2007-08-02 |
| WO2007085626A1 (en) | 2007-08-02 |
| JP2009524622A (en) | 2009-07-02 |
| NO20082787L (en) | 2008-10-13 |
| CA2640010A1 (en) | 2007-08-02 |
| EP1987054A1 (en) | 2008-11-05 |
| RU2520817C2 (en) | 2014-06-27 |
| IL192320A0 (en) | 2008-12-29 |
| KR20080088610A (en) | 2008-10-02 |
| RU2008134479A (en) | 2010-02-27 |
| US20100261651A9 (en) | 2010-10-14 |
| AU2007209363B2 (en) | 2013-08-22 |
| US20090221491A1 (en) | 2009-09-03 |
| ZA200806382B (en) | 2009-06-24 |
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