UA94418C2 - Bicyclo[2.2.]hept-7-ylamine derivatives and their uses - Google Patents

Abstract

Compounds of formula (I) have muscarinic M3 receptor modulating activity; Formula(I) wherein A is an oxygen atom or group -N(R)-;(i) Ris C-C-alkyl or a hydrogen atom; and Ris a hydrogen atom or a group -R, -Z-Y-R-Z-NRR; Z-CO-NRR; -Z-NR-CO-R; or -Z-COH; and Ris a lone pair, or C-C-alcyl in which case the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; or (ii) Rand Rtogether with the nitrogen to which they are attached form a heterocycloalkyl ring, and Ris a hydrogen atom; or a group -R, -Z-Y-R, -Z-NRR, -Z-CO-NRR, -Z-NR-CO-R, or -Z-COH, in which cases the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; or (iii) Rand Rtogether with the nitrogen to which they are attached form a heterocycloalkyl ring, said ring being substituted by a group -Y-R, -Z-Y-R, -Z-NRR; -Z-CO-NRR; -Z-NR-CO-R; or -Z-COH and Ris a lone pair, or C-C-alkyl in which case the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; Ris a group of formula (a), (b), (c) or (d); is an C-C-alkil, aryl, aryl-fused-cycloalkyl, aryl-fused-heterocycloalkyl, heteroaryl, aril(C-C-alkil)-, heteroaryl(C-C-alkyl)-, cycloalkyl or heterocycloalkyl group, and the remaining variables are as defined in the specification.(I),(a),(b),(c),(d)