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Application filed by Займоджинетикс, Инк.filedCriticalЗаймоджинетикс, Инк.
Publication of UA93179C2publicationCriticalpatent/UA93179C2/en
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents
(AREA)
Peptides Or Proteins
(AREA)
Abstract
The present invention relates to a monoclonal antibody or fragment thereof that specifically binds to an antigenic epitope of human IL-22RA (zcytor 11), wherein the antibody reduces or neutralizes the activity of human IL-22. The invention further relates to a method for inhibiting IL-22-induced proliferation or differentiation of hematopoietic cells and hematopoietic cell progenitors, a method for reducing IL-22-induced inflammation in mammal, a method for suppressing an inflammatory response in a mammal with inflammation comprising comparing the level of serum amyloid A protein prior to admininstering composition of an antibody and after said administering.
UAA200509928A2003-03-242004-03-24Antibody that specifically binds to il-22ra antibodies and methods of using thereof
UA93179C2
(en)
Ability of myeloma cells to secrete macrophage inflammatory protein (MIP)‐1α and MIP‐1β correlates with lytic bone lesions in patients with multiple myeloma
a method for producing an antibody to a polypeptide, antibody produced therein, antibody or antibody fragment that binds to a polypeptide, methods for reducing or inhibiting il-20 induced proliferation or differentiation of hematopoietic cells and hematopoietic cell progenitors, to reduce il-20 induced inflammation, to suppress an inflammatory response in an inflamed mammal, to treat a mammal afflicted with an inflammatory disease, to treat a pathological condition in a patient associated with il-20 activity
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