UA91325C2 - Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity - Google Patents
Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activityInfo
- Publication number
- UA91325C2 UA91325C2 UAA200507468A UA2005007468A UA91325C2 UA 91325 C2 UA91325 C2 UA 91325C2 UA A200507468 A UAA200507468 A UA A200507468A UA 2005007468 A UA2005007468 A UA 2005007468A UA 91325 C2 UA91325 C2 UA 91325C2
- Authority
- UA
- Ukraine
- Prior art keywords
- chemokines
- cytokines
- antagonists
- growth factors
- binding activity
- Prior art date
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a method for synthesizing conjugates of one or more synthetic water-soluble polymers with a cytokine, a chemokine, a growth factor or a polypeptide hormone, or an antagonist thereof, comprising:(a) selecting a cytokine, chemokine, growth factor or polypeptide hormone in which the amino-terminal amino acid is located remotely from one or more receptor-binding domains of said cytokine, chemokine, growth factor or polypeptide hormone, or antagonist thereof; and(b) coupling said one or more polymers selectively to said amino-terminal amino acid.The invention further relates to a conjugate prepared by said method, to a pharmaceutical composition comprising the conjugate, and to a method for preventing, diagnosing, or treating a physical disorder mediated by said proteins.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43602002P | 2002-12-26 | 2002-12-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA91325C2 true UA91325C2 (en) | 2010-07-26 |
Family
ID=37134126
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200507468A UA91325C2 (en) | 2002-12-26 | 2003-12-23 | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
| UAA200507467A UA90654C2 (en) | 2002-12-26 | 2003-12-23 | Polymer conjugates of interferon-beta with enhanced biological potency |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200507467A UA90654C2 (en) | 2002-12-26 | 2003-12-23 | Polymer conjugates of interferon-beta with enhanced biological potency |
Country Status (3)
| Country | Link |
|---|---|
| CN (2) | CN1852732A (en) |
| UA (2) | UA91325C2 (en) |
| ZA (2) | ZA200505394B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008247815B2 (en) * | 2007-05-02 | 2012-09-06 | Ambrx, Inc. | Modified interferon beta polypeptides and their uses |
| MX2011002055A (en) * | 2008-08-25 | 2011-03-30 | Viromed Co Ltd | Biopolymer conjugates comprising an interleukin-11 analog. |
| CA3144697A1 (en) * | 2010-11-12 | 2012-05-18 | Nektar Therapeutics | Conjugates of an il-2 moiety and a polymer |
| AR096890A1 (en) * | 2013-07-12 | 2016-02-03 | Hanmi Pharm Ind Co Ltd | CONJUGATING FC OF IMMUNOGLOBULINA, THAT MAINTAINS THE UNION AFFINITY OF THE FC FRAGMENT OF THE IMMUNOGLOBULIN TO FCRN |
| WO2018170480A1 (en) * | 2017-03-16 | 2018-09-20 | Blaze Bioscience, Inc. | Cartilage-homing peptide conjugates and methods of use thereof |
| AU2015284248B2 (en) * | 2014-06-30 | 2020-04-16 | Altor Bioscience Corporation | IL-15-based molecules and methods of use thereof |
| CN104725482A (en) * | 2015-04-06 | 2015-06-24 | 苏州普罗达生物科技有限公司 | Platelet-derived growth factor antagonistic polypeptide and applications thereof |
| WO2019222294A1 (en) * | 2018-05-14 | 2019-11-21 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| CN113797318B (en) * | 2021-10-26 | 2023-06-30 | 深圳科兴药业有限公司 | Interferon composition and preparation method and application thereof |
| CN117711525B (en) * | 2024-02-05 | 2024-05-10 | 北京悦康科创医药科技股份有限公司 | Activity prediction model training and activity prediction related products |
-
2003
- 2003-12-23 CN CNA2003801090344A patent/CN1852732A/en active Pending
- 2003-12-23 ZA ZA200505394A patent/ZA200505394B/en unknown
- 2003-12-23 CN CN 200380109611 patent/CN1859925A/en active Pending
- 2003-12-23 UA UAA200507468A patent/UA91325C2/en unknown
- 2003-12-23 UA UAA200507467A patent/UA90654C2/en unknown
- 2003-12-23 ZA ZA200505393A patent/ZA200505393B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200505394B (en) | 2007-03-28 |
| ZA200505393B (en) | 2007-03-28 |
| CN1852732A (en) | 2006-10-25 |
| UA90654C2 (en) | 2010-05-25 |
| CN1859925A (en) | 2006-11-08 |
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