UA89963C2 - Tetrahydrocarbazole derivatives with improved biological action and improved solubility as ligands for g-protein coupled receptors (gpcrs) - Google Patents

Tetrahydrocarbazole derivatives with improved biological action and improved solubility as ligands for g-protein coupled receptors (gpcrs)

Info

Publication number
UA89963C2
UA89963C2 UAA200701545A UAA200701545A UA89963C2 UA 89963 C2 UA89963 C2 UA 89963C2 UA A200701545 A UAA200701545 A UA A200701545A UA A200701545 A UAA200701545 A UA A200701545A UA 89963 C2 UA89963 C2 UA 89963C2
Authority
UA
Ukraine
Prior art keywords
gpcrs
improved
ligands
protein coupled
coupled receptors
Prior art date
Application number
UAA200701545A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Клаус ПАУЛИНИ
Маттиас ГЕРЛАХ
Экхард ГЮНТЕР
Эммануэль Полимеропоулос
Силке Бааснер
Петер ШМИДТ
Рональд Кюне
Арвид Зодерхалл
Original Assignee
Центарис Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102004033902A external-priority patent/DE102004033902A1/en
Application filed by Центарис Гмбх filed Critical Центарис Гмбх
Publication of UA89963C2 publication Critical patent/UA89963C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to novel tetrahydrocarbazole derivatives with improved properties, of application as inhibitors of GPCRs. The possibility is thus provided for the treatment with the novel compounds of disease states the expression of which depends on the pathological biochemical action of GPCRs. Said compounds have a particular antagonistic inhibition of the LHRH receptor. The invention further relates to medicaments comprising one or more of the novel compounds as active ingredient. The medicaments are particularly suitable for application in mammals and humans in oral dosage form.
UAA200701545A 2004-07-14 2005-07-05 Tetrahydrocarbazole derivatives with improved biological action and improved solubility as ligands for g-protein coupled receptors (gpcrs) UA89963C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004033902A DE102004033902A1 (en) 2004-07-14 2004-07-14 New tetrahydrocarbazole compounds are neurokinin-1 receptor antagonists useful to treat or prevent e.g. pubertas praecox, hirsutism, polycystic ovary syndrome, hormone dependent neoplastic diseases and Alzheimer's disease

Publications (1)

Publication Number Publication Date
UA89963C2 true UA89963C2 (en) 2010-03-25

Family

ID=40951405

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200701545A UA89963C2 (en) 2004-07-14 2005-07-05 Tetrahydrocarbazole derivatives with improved biological action and improved solubility as ligands for g-protein coupled receptors (gpcrs)

Country Status (2)

Country Link
UA (1) UA89963C2 (en)
ZA (1) ZA200609436B (en)

Also Published As

Publication number Publication date
ZA200609436B (en) 2009-01-28

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