UA88771C2 - Proteasome inhibitors and methods of using the same (variants) - Google Patents

Proteasome inhibitors and methods of using the same (variants)

Info

Publication number
UA88771C2
UA88771C2 UAA200602694A UAA200602694A UA88771C2 UA 88771 C2 UA88771 C2 UA 88771C2 UA A200602694 A UAA200602694 A UA A200602694A UA A200602694 A UAA200602694 A UA A200602694A UA 88771 C2 UA88771 C2 UA 88771C2
Authority
UA
Ukraine
Prior art keywords
methods
variants
same
proteasome inhibitors
compositions
Prior art date
Application number
UAA200602694A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Альберто Бернареджи
Паоло Дж. Кассара
Шанкар Чаттерджи
Эдмондо Ферретти
Мохамед Икбал
Эрнесто Мента
Маклаугхлин Патрисия А. Мессина
Амброджио Олива
Джермано Дьаразмо
Мунари Серджио Де
Рафаэлла Бернардини
Original Assignee
Сефалон, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сефалон, Инк. filed Critical Сефалон, Инк.
Publication of UA88771C2 publication Critical patent/UA88771C2/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
UAA200602694A 2003-08-14 2004-08-13 Proteasome inhibitors and methods of using the same (variants) UA88771C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49576403P 2003-08-14 2003-08-14

Publications (1)

Publication Number Publication Date
UA88771C2 true UA88771C2 (en) 2009-11-25

Family

ID=37426112

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200602694A UA88771C2 (en) 2003-08-14 2004-08-13 Proteasome inhibitors and methods of using the same (variants)

Country Status (7)

Country Link
CN (1) CN1867572B (en)
AR (2) AR045381A1 (en)
MY (1) MY162518A (en)
PE (1) PE20050360A1 (en)
TW (1) TWI345465B (en)
UA (1) UA88771C2 (en)
ZA (1) ZA200601293B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105837608B (en) * 2007-08-06 2018-06-08 米伦纽姆医药公司 Proteasome inhibitor and combinations thereof and purposes
GEP20125599B (en) * 2007-08-06 2012-08-10 Millennium Pharm Inc Proteasome inhibitors
CN102961387B (en) * 2007-08-06 2016-04-27 米伦纽姆医药公司 Proteasome inhibitor
DK2730581T3 (en) * 2008-06-17 2016-08-15 Millennium Pharm Inc Boronate Ester Compounds and Pharmaceutical Compositions thereof.
CN101638414B (en) * 2008-07-30 2014-01-08 江苏先声药物研究有限公司 Peptidyl boronic acid, ester compound thereof, preparation method of peptidyl boronic acid and ester compound thereof, and use of peptidyl boronic acid and ester compound thereof
AR075090A1 (en) * 2008-09-29 2011-03-09 Millennium Pharm Inc ACID DERIVATIVES 1-AMINO-2-CYCLLOBUTILETILBORONICO PROTEOSOMA INHIBITORS, USEFUL AS ANTI-BANKER AGENTS, AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM.
CN101747354B (en) * 2008-12-04 2014-08-13 江苏先声药物研究有限公司 Dipeptide boronic acids consisting of beta amino acids, ester compounds and preparation methods and uses thereof
CA2785300A1 (en) * 2009-12-22 2011-07-21 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
CN102892291A (en) * 2010-03-31 2013-01-23 米伦纽姆医药公司 Derivatives of 1-amino-2-cyclopropylethylboronic acid
RU2717558C2 (en) * 2014-10-01 2020-03-24 Мерк Патент Гмбх Boronic acid derivatives
CN106588965A (en) 2015-10-15 2017-04-26 北京大学 Urea peptidomimetic boric acid compound as well as pharmaceutical composition, preparation method and application thereof
WO2017198194A1 (en) * 2016-05-19 2017-11-23 成都奥璟生物科技有限公司 Boronic acid and borate ester compound and applications thereof
PL3571208T3 (en) * 2017-01-18 2021-09-20 Principia Biopharma Inc. Immunoproteasome inhibitors
TW201831191A (en) * 2017-01-23 2018-09-01 大陸商成都奥璟生物科技有限公司 Novel boric acid derivative and pharmaceutical composition using same
CN114437119A (en) * 2020-10-30 2022-05-06 苏州开拓药业股份有限公司 C-Myc protein inhibitor and preparation method and application thereof

Also Published As

Publication number Publication date
AR045381A1 (en) 2005-10-26
TW200529810A (en) 2005-09-16
TWI345465B (en) 2011-07-21
AR095249A2 (en) 2015-09-30
MY162518A (en) 2017-06-15
PE20050360A1 (en) 2005-06-10
CN1867572A (en) 2006-11-22
ZA200601293B (en) 2009-09-30
CN1867572B (en) 2012-03-28

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