UA87744C2 - Composition containing nanoparticles of gold and method for its production - Google Patents

Abstract

A composition containing nanoparticles of gold and method for its production relate to the field of the chemical technology, namely to nanocompositions containing the metallic silver in nanodisperse state. The technical result consists in obtaining the stable composition combining the consumer properties and low toxicity, which provides for the highly effective composition for food and pharmaceutical industries. The essence of the invention consists in using at least one carbohydrate as the stabilizer. This may be monosaccharide, disaccharide or soluble polysaccharide. The natural carbohydrate complex, namely the honey, may be used as a stabilizer. The composition contains (in mass %) 0.000001-10% of nanoparticles and 1-90% of the carbohydrate with water or aqueous-alcohol complex representing the rest. The composition is produced by reaction of the solution of gold hydrochloric acid with the reducing agent in the presence of the stabilizer, namely the carbohydrate, and in the presence of hydroxide of alkaline or alkaline-earth metal and/or citrate and/or sodium ascorbate. The composition can be used for manufacturing food, cosmetic and pharmaceutical aqueous or aqueous-alcohol preparations.

Claims (5)

OTHERS AND UKRAINE AND SA a she Se TSI (1 MAK (2009) ee AVIK 31/79 (2007.01) tower AVIK 33/00 MINISTRY OF EDUCATION ENAUKY OF UKRAINE STATE DEPARTMENT o. Her U S INTELLECTUAL TO THE PATENT FOR THE INVENTION BLASNOST (58) COMPOSITION CONTAINING GOLD NANOPARTICLES, AND THE METHOD OF OBTAINING 1 and 21) a200732515 hydrohydrogen acid with a reducing agent in the presence of a stabilizer, which is distinguished by the fact that as g245r10.08 2905 stabilizer they use a carbohydrate, as mutually. 8 TOYA 2009, byul.me 15, 2009, the effect of caustic soda solution with 12 USATENKO OLEKSANDR VASYLYOVYCH, SCHE- the presence of alkaline pdroxide or lucnozemel- RBAKOV OLEKSANDR BORISOVYM, KUSCHEVSKA talaba citrate is carried out with a reducing agent. and/or vocorbate of NINA FEDOENVNA, POVH HRYGORY BASILYOTRIUM, while the poxide of the metal metal is taken as an equimolar solution, ITZBUSATENKO OPEKSANDE VASYLYOVYCH, which provides nitralization of the free acid contained in the solution of carbohydrates and/or or to neutralize - PA Я7Б55, 0, 15.10.2006 this hydrochloric acid formed in the process of regeneration 571 composition containing nanoparticles of ash 5. The solution according to claim 4, which is characterized by the fact that in an aqueous or aqueous-alcohol solution, which emodiation of the acid and the reducing agent is carried out at the same time, it includes a stabilizer, which is characterized by the fact that the temperature of 82- 90 76. as a stabilizer, it contains at least one of p. The method according to claim 4, which differs in that as carbohydrates with this ratio of components, the stabilizer uses monosaccharides, which have a mass Che: saccharides or water-soluble polysaccharides, or nanoparticles of sugars prepared by synthetic, enzymatic, or artificial carbohydrates 1-80, such as glucose, fructose, sucrose, water or water-based crushed raw materials, patozha , dextrin, galactose, c) rank the rest. mannose, starch, gudrova gum, koanta gum - Fu 2. The composition according to claim 4, which differs in that it is new, kaelzan., but as a carbohydrate it contains monosaccharides, opigosv- 7. The method according to claim 4, which differs in that natural carbohydrates are used as soluble or soluble polysaccharides, restrained syn stabilizers , by enzymatic or artificial means, complexes: honey, concentrates of natural juices, such as glucose, fructose, sucrose, corn syrups. zh syrup, molasses, dextrin, galactose, mannose, crumb - I. The method according to claim 4, which differs in that, as gonya mal, guvrov gum, xanthan gum, kel- the reducing agent uses such carbohydrates as gluten, goat, fructose , maltose, lactose, celobirza, sleep a. Z. The composition of the article, which differs in that it contains patriose, maltotriose. SA as a carbohydrate, it contains natural hydrocarbon complexes. The method according to claim 8, which differs in that carbon complexes, such as: honey, concentrates of natural co-carbohydrates, are taken in an amount that exceeds the content of kiva, syrups, sap, which restore 2.5 times. 4 The method of obtaining the composition according to claim 1, also contains 10. blosib according to claim 4, which is carried out by the fact that as nanoparticles of gold, in which the reduction from the reducing agent using citrate or ascorbate is carried out by the interaction of a sodium ash solution, and the invention belongs to branches of chemical technology, pharmaceutical or other preparations on water pine, in particular to compositions that contain metallic gold in alcohol and/or water-alcohol mixture. in a nano-dispersed state, which is stabilized by Nenchak. A known method of obtaining nanoparticles is zoplosic products, and can be used and and: From VT 4 POTOOBTe0Ya, MK VOREV2Ya, "Meshtovyv apisivv soluble in water, hydrogen peroxide or spir iz ed! by the fern of Rechenov, published in tovo-water systems, which as stabilizing OVOZ 200. The method of obtaining nanoparticles of other additives contains food products, as well as introduction into tea peat moss containing gold, in the development of a method of obtaining such a composition; day of phosphino-amino acid, because the trimer (TAKA, the Technical result in the curing of stable phosbino-trimer of alanine acid), the reaction of my composition containing nanoparticles of metallic substances. The method includes the exposure stage of gold, which combines the consumer properties of nanoparticles of zopota in one or more stages and the low toxicity of auxiliary compenents that clog. selected from the group: starch, agarose and will provide the entire complex of characteristics - deafness. contact of a highly effective drug during application" Starch, agarose and glucose. as it flows out of the bath in the food and pharmaceutical industry. description of the application, not by nucleation promoters, because the indicated technical task and technical results can be added to the system after the formation of tats are achieved thanks to the composition containing gold nanoparticles, primarily with the purpose of oxidizing gold nanoparticles in water, water-based nanogroups of particles ( nanochains). Regenerative alcohol or alcohol-aqueous SOLUTION and the usual stabilizing agent is phosvinoylizate, and, contrary to the invention, as a stable amino acid. If it is necessary to form in the reactor, the composition contains at least one of the parts of the pla man of gold nanoparticles in this carbohydrate with this ratio of components, the site is injected with a material that contains gold, and in mass: phosphimo-aminophosphorus, which leads to the formation of gold nanoparticles ОО 1-10 ration of gold nanoparticles in the above-mentioned determination of Men Mii site. water or aqueous solution According to the invention, the composition of the composition as a carbonaceous layer contains zopsota salt, and water can mark monosaccharides, opegosaccharides, and the second "phosphino-amino acid." During digestion, idisaccharides) and soluble polysaccharides, the resulting gold salt and phosphino-aminokispota can be synthetically, enzymatically, or artificially reduced by the formation of gold nanoparticles, homo. such as glucose, fructose, sucrose, corn" A known composition containing nanoparticles of cottage cheese, molasses, galactose, mannose, guar metafoam gold in water, water-alcohol gum, xanthan gum, calzane, dextrin, and alcohol-water mixture, in the presence of starch. biliizer, which is fieldM-viniynvoliden, at tako. The composition may also contain the following carbohydrates, in the ratio of the components, by mass: nanoparticle-like maltose, lactose-pactulose, pectin, gum (golden beads BDUT - 0; poly-m-vinylpyrrolidone rye, oat, alder tree, tare, galanova and UN - 85.7; the rest - water, hydroalcoholic inia), carrageenan, agar and agaroids. or alcohol-water ratio, This composition of oil is like a carbohydrate. the composition may contain natural honey in the deparation patent of Ukraine Me 17555, No hydrocarbon complexes: honey. concentrates of natu-MAK Stos yuovVigoov oi, AUTO-pural juices, syrups. As you know, honey contains btkovanomu in Bul. Me 30, 18.10.2005, Trocoase, fructose, sucrose. dachshrine, Acacia There is a known method of obtaining a composition that has the highest glucose content (grapes containing nanoparticles of metallic gold, described in sugar), which is a Zydnovplukchy hydrocarbon, in the declaratory patent of Ukraine. Me 5095, paddy honey practically does not contain reducing MICROOVI AVTKZ OVO, ABTKZUMZV, publ" carbohydrates. forged in bull. May 17, 2005. According to the analysis of scientific and technical information A conscious way of obtaining the composition, that the claimed composition is new in terms of its quality and contains nanoparticles of zopota, recovery of gold by quantitative composition. The use of momo- | disaccha- is carried out by the interaction of a solution of zoopotochlorides and also popisaccharides as a stabilizer of hydrous acid with a reducing agent in the presence of a pochimeric oostabilizer in the process of obtaining gold nanoparticles, which is a polyode. vinyltroldone Citrate or sodium ascorbate are used as reducing agents. the result is also achieved thanks to the method This known composition and method are the closest to the proposed solution for the preparation of a composition containing nanoparticles. of gold, in which gold recovery is carried out Analyzing the known compounding methods and their interaction with the gold hydrogen chloride solution, it should be noted that the toxicity of the compound acid with the reducing agent in the presence of a stabilizer is determined only by the toxicity of the active substance (according to the invention, metal nanoparticles are used as a stabilizer), but toxicity is a carbohydrate. Interaction of an acid solution with a reducing agent. stabilizer and other auxiliary components are carried out in the presence of hydroxide alkali components. Bidom compositions, in addition to the metal base or powder-ground metap and/or citrate, of gold in a nanodispersed state contain non-food substances such as sodium ascorbate. Alkaline hydroxide or components that have limitations in the case of alkali-absorbing metal or citrate, used as a catalyst (poly-M-vinylpyrrolidone, TAASI. Sodium vokorevt is taken in an amount that provides The technical problem solved by the invention is the neutralization of the free acid contained in the claimed solution. from the creation of a composition that represents carbohydrates, and/or nitralization of hydrochloric acid, a stable complex of metallic gold, sweat, is formed in the process of recovery. yati B Excess free acid is not present in all tru this solution introduces citrate zbo aocorvate na- natural carbohydrates. for example, it is present in three. In a cold container, prepare an aqueous solution in natural honey (apple, amber, lemon salt, gold with isopotochorhydrogen acid. It is too hot and must be neutralized. In the case of intensive continuous mixing, in the case of using syrup or molasses, if it is not given a second solution. which is clearly cooled to room temperature. that of sodium. Example With regard to the neutralization of hydrochloric acid, the SPO preparation of a composition containing the following should be noted. Gold-hydrochloric acid nanoparticles of gold, stabilized by carbohydrates, during the reduction of dosometal creates an equimolar was carried out as follows thus, the amount of hydrochloric acid, which is higher has a toxicity of 1. A solution of 1.30 g of 134 mm of the system was prepared in a container, which interferes with the recovery process. of sodium oxide (including I MM for neutral" must be neutralized, namely, transfer to free acid B 500 Mb of flower honey (for ketoxic food network - sodium chloride. for this, the total number of carbohydrates is 785, in that amount - it is necessary hydroxide of alkaline or lucnose-895 glucose, the content of acids titrated to 0.155) of the metal, for this purpose it is possible to use a solution of 3.2 g of tetrahydro-citrate or sodium dokorevt. NATSSIN NOU V 10 ve of distilled water with a reducing agent is carried out at a temperature of 82 - KE 2. The first solution was heated to VY S g at inten C. This temperature is quite sufficient for the second ensuring an effective recovery process of the solution. Heating (827 C | continuous stirring) of the sweat. On the other hand (Ku, when using honey, boil for 25 minutes. The combined solution of wormwood at a higher temperature leads to DdDOloss. It changed from light-matte-brown due to its healing properties. brown to red-brown, Monosaccharides, disaccharides are used as stabilizers in the process of manufacturing compo- Z. Urozory in a thin layer of purple color. A red solution of Г1-500 ml, taking into account water, (oligosaccharides) or water-soluble polysaccharides that evaporated) contained 71.5 g of nanoparticles of zo» obtained synthetic, enzymatic or starch, stabilized by carbohydrates and can be used in a useful way, such as glucose, fructose, sacchatuated for the preparation of food, cosmetic, kukuwood syrup, molasses, dextrin, galactine or pharmaceutical compositions or for, mannose, starch, guar gum and to be stored. xanthanovia), kelzan. The main advantage of such a composition is the results obtained, thanks to the presence of honey, its properties and its absence. maltose, lacto-paiulose, pectins, gums (the absence of any impurities, except for sodium chloride, oats, carob, tare, gelan and tro (kitchen salt in the amount of 1.28 pp. ini), carrageenan, agar agenoids. An example of a stabilizer can be used. The method of preparation of the composition also contains natural carbohydrate complexes: honey, concentrates of gold nanoparticles stabilized by carbohydrates, natural juices, syrups. was carried out as follows; In the process of making the composition, 1. In a container, a solution of 1 was prepared .68 g (42 MM of sodium hydroxide, including 12 MM for neutral" example: glucose, fructose, maltose, packtose, zations of free acids) and 8.4 g (34 mM) trisodium cytepobose, sopatrius, maltotriose, in a volume of 500 ml of honey (total content of 75 g of carbohydrates as a carbohydrate stabilizer, acids titrated to 0.35 V and a reducing agent, according to the invention, reducing agents were prepared in a separate container n 3.2 g of tetrahydrate, carbohydrates are taken in an amount that exceeds the content of zapotochlorovHydrogen solution of 18 mm of gold, which is reduced, by approximately 2.5 times. ON YANIV Uu 10 ml of distilled water. In order to obtain gold particles in the nanodisc" 2. The first solution was heated to 100 °C and with a knteronic dpazom, it is possible to introduce an additional amount of reducing agent into the system with intensive mixing. Solution. Heating (827 C) continued mixing. In the reducing agent it is possible to use mitrate vala 25 xvypins. The color of the combined solution after or absorption of the alkali metal. long changed from light brown due to the proposed composition, which contains nano-brown to vinous red. HEAR NKS GOLD, stabilized by carbohydrates, peel- I Transparent in the ruby-red thin layer is chewed as follows, the solution -500 mp, taking into account the water that evaporates - In the container, a solution of alkaline oxalate hydroxide is prepared) contained 1.5 g of nanoparticles of gold, a stable metal, which is taken in an equimolar amount (dpya pized by carbohydrates and can be used to neutralize the free acid contained in the preparation of food, cosmetic products, in native solutions of carbohydrates, and to neutralize headlights medicinal compositions or to be stored. of hydrochloric acid formed in the system with The advantage of such a composition is obtained due to the reduction of gold hydrochloric acid) in water, the presence of honey, additional valuable properties and a new solution of one of the carbohydrates. If necessary 7 8744 V more homogeneous fractional composition of the particles of the clay is similar to Prykpad 5, p.i., with the exception of nastulot. 20th century Example C 2. Acidic solution of coditan gum and gold. The method of preparation of a composition containing hydrofluoric acid with intensive pereami- gold nanoparticles was carried out in the same way as priming and drinking CH E) for 20 minutes. I put, with the exception of the following: Yellow solution at the same time obezOvorvVivVoy. B boder Instead of sodium citrate, a liquefied solution was used, a solution of OV was introduced and a hydrocommolar amount of natron was added (34 MM of sodium in m of distilled water. Example 4 C. Carbohydrate carrier, zopothochlorohydrogen salt. Method of preparation of a composition containing acid and sodium hydroxide with intensive stirring of a gold nanoparticle, stabilized by carbohydrates, was heated (807 C for 50 minutes. The color of the solution gradually changed from 1. Veyuvnosti prepared a solution of 1.954 g of 31 MM) and light peach through lilac to purple. of sodium dronside and 19.5 g (BO mM trisodium citrate- 5. Transparent in a thin layer red. that in 500) ml of corn molasses containing ZVO" violet solution (100 ml, taking into account water, carbohydrates (455 mono- and disaccharides) A solution of 3.2 g of gold-gold tetrahydrate, stabilized 0.0 g of carbohydrates was prepared in a separate chamber that evaporated) containing 0.05 g of nanoparticles. Hydrochloric acid chloride 17.6 MM NANSIA YAN in SO sodium, and can be used to prepare mp distilled water. food, cosmetic and/or pharmaceutical products 2. The first solution was heated to 857 °C with intensive compositions that could not be collected, the second solution was introduced into it under vigorous stirring. the film for 25 minutes. The color of the combined solution was successively increased. The obtained easily soluble black changed from light brown to cinnamon-Fislet powder, contained approximately 0 to brownish-red. i-795) zopot nanoparticles, b 1-74) carbon - Z. Transparent ruby-red virgin in a thin layer, 0.19 gi-1795) Mass! and low viscosity. Volo's solution (1-50 ml, taking into account the water that evaporates and evaporates) contained about 1.2 g of gold nanoparticles, it is known that Kovantan gum (a synthetic product of Hapioptopav saptrevyv can be used) represents The process of preparing food and cosmetic products is a polysaccharide in which the main chain of pharmaceutical compositions or aggregates. consists of two fragments of B-STUKOZy, ZVYaya Lryklad 5 zani in position 1 4 (in the side pantsyuz of Ms. The method of preparation of a composition containing two mannoses and glucuronic acid). In this case, gold nanoparticles, stabilized by carbohydrates, cooled xanthan gum when heated in oxygen was carried out in the following manner: in an aqueous solution, it partially hydrolyzes and 1. Volumes prepared a solution of 0.5 g of xanthan gum forms a sufficient concentration of free reducing gum in 100 ml of distilled water . It is full of carbohydrates (end groups) as follows. then dissolution into the resulting viscous solution was mixed with metal gold from 0.105 g of gold-hydrochloric acid tetrahydrate of caustic acid under stirring. M NAS YAN in Her we distilled water. Example 7 7. Pour a solution of 0.08 g into the obtained solution. gold nanoparticles stabilized by carbohydrates, Z. In a separate container, a solution of 1.25 g was prepared as follows: 1 mM) of trinatium citrate in 10 ml of distilled water was prepared in a container. of copper in 103 ml of distilled water. I drank full J. The first solution was heated to 100 °C and, with intense dissolution, 0.83 g of tetrahydrochloric acid was added to the resulting viscous solution with stirring. Heating to 82" C and stirring was continued for 25 minutes. The color of the depleted solution was 0.18 g, which was prepared in a sealed container, successively changed from light-dark through cinnamon and 4 mM) of sodium hydroxide in 1 ml of distilled nevi to red-brown. 5. Transparent in a thin layer of red-C. The first solution was heated to VO b at intensive brown solution (100 ml. including water, with vigorous stirring, a second solution was introduced into it, which evaporated! contained (05 g of nanoparticles). Heating (VO " C) and mixing gold food, stabilized 0.5 g of carbohydrates, and non-toxic chewables for 5 min. The color of the combined solution food inorganic components (citrate and chloride changed successively from light gray to rubic sodium! and can be used for preparing of red food, cosmetic and/or pharmaceutical 5. Transparent in a thin layer, the red solution of the compositions or stored (when introducing 4100 ml of carbon black, taking into account the water that evaporated) contained "0.1 g of gold nanoparticles, stabilized Example b 0.5 g of carbohydrates and sodium chloride, a method of preparing a composition that can be used for the preparation of food, cosmetic gold nanoparticles, stabilized with carbohydrates, tapbo pharmaceutical compositions and, to be dried without additional introduction of reducing agents. carried out - or collected in the native form or when introducing khonservantiyav). With VT 18, the distinguishing feature of this example is the preparation of a high volume solution of 10 g of a co-structural solution of small nanoparticles: de-corn in 500 ml of distilled water with a low viscosity (comparable parameters for complete dissolution in the resulting viscous solution with the best samples , which contain the gold hydrogen chloride substitute added by chemical synthesis) without the use of the added acid SBmMM NAS H, organic reducing agents. 2. In a separate container, soluble, g Example 8 (31 mM) sodium hydroxide in 10 mL of distilled water was prepared. Both solutions were mixed. gold nanoparticles stabilized by carbohydrates, C The combined solution was placed in a household mi" was carried out as follows: a crumb furnace Apimop MUZA Viv xx. 4 158 containers were kept, a solution of 5 g of calzane was prepared (OK cykim opo is minutes, not allowing overheating Kenso, CYU) in drink ml of distilled water. After (900 W). of complete dissolution into the resulting viscous solution 5 The hardened temmo blue solution contained 1.05 g of zapotochlorohydrogen tetrahedron mg of gold nanoparticles, stabilized by 5.5 g of carbonic acid (2.5 MM NAS YAN, sodium chloride sodium chloride, and can be used 2. In a separate container, a solution of 04 g for the preparation of food, cosmetic tea, or PO MM) of sodium hydroxide was prepared in 100 ml of distilled pharmaceutical compositions, to be dried or water. ). C. The combined solution was transferred to the ultrasound. Examples 9-10 are given to illustrate the different ZOMOVEH BIOREV installation as 00 physical methods of activation of the recovery process and (ShNgaseotspa Co, a standard installation for the purification- formation of gold nanoparticles by carbohydrates. Horse and desinoasection of the medical instrument ) ! performed cycles of irradiation of 10 minutes each (35 KgC 100 W, sizes and shapes of nanoparticles obtained (in 4. silvery dark burgundy, transparent depending on the method of production). a thin layer of a solution (1000 ml, taking into account Example 13 water that evaporated) containing 5900 mg of manochase for preparation was carried out as follows: food, cosmetic and/or bottling 1. Put BO g of potato croc of pharmaceutical compositions in the container, dry or mago and 850 ml of distilled water. -90) minutes, the system was heated to temperatures). foam and stirred for 30-40 minutes until complete dissolution of the starch, after which it was introduced into it. carried out as follows: three. In a separate container, solution C was prepared, hot 1. In a container, a solution of 85.5 g of chelsan rehydrate of zopothochlorohydrogen acid 7.5 MM (CSO Kaiso, OK) in 500 ml of distilled water was prepared. Powder of NATSII YAN in 10 ml of distilled water. complete dissolution into the resulting viscous solution 2. Without applying heat (357 3) and adding 0.5 P of zoletochlorohydrogen tetrahydrate with vigorous stirring, pour the second solution into 25 mM NaCl acid. first. Heating (Z0" Si stirring pro- 2. A solution was prepared in a separate container and kept for 25 minutes. The color of the combined solution (5 mM) of sodium hydroxide in 10 ml of distilled water successively changed from light yellow to gray water. Both solutions changed, while yellow to dark red, the color became discolored. Q. After cooling in a separate container, the combined solution was transferred to a quartz glass, 200 g of the resulting solution was taken and, while stirring, the beaker was irradiated with ultraviolet light, and 2 g of the solution obtained in TOUZO RyNov solder, a bactericidal ultraviolet put 1; 5 g of glycerin; With g of aluminum potassium alum; va lamp) for 40 minutes (30 W) at a temperature of 0.5 water-soluble vitamin E; 2 g of panthenol; 2 rapid mixing with a glass spatula goaplanton, with bisabolol; 20 g of extract with a stirrer. catch-believe; BO g fenokovtanov. 5. The resulting simesriolet, transparent in 4. The solution was poured into a teevlon mold, a thin layer of the solution (500 M) was added to the eBO mg mV with a BO0O cm, dried in a thermal oven at a temperature of gold particles, stabilized 2.5 g of carbohydrates natrik, and can be used for 5. The obtained dark red flexible film is the preparation of food, cosmetic products, it can be used as a coomen of medicinal compositions, it can be dried or stored as a mask for rejuvenating aging skin. face. Chivh This example is given dpya ipustovtsy mozh Example 10 left cosmetic use of the composition, which Method of preparation of the composition, which contains declared. gold nanoparticles stabilized by carbohydrates To obtain specific compositions, the summation is carried out as follows: gold nanoparticles stabilized by carbohydrates 11 BUT 18, if necessary, is dissolved in water, water is given in ssvd, and the use of a larger amount of alcohol or alcohol-water solution, carbohydrate, does not give additional positive ren. composite result, but only leads to excessive consumption of zions, in the limited range of components of composite conductors. zition is stable (gold particles do not fall out in the stated homoposition, as mentioned above, in the ased; they have a similar sfoaction shpadou has increased stability! reduced toxicity in the nanodisperse range, have a much smaller, compared to known solutions. The zone can be toxic in comparison with known compositions. be used as a cosmetic, sramceutical Make homopositions with a smaller amount of nano-preparation and/or biologically active food day: particles will not miss the point and not pointless, since it is a nutritional supplement), for the production of volatile alcohols has given a tangible positive result. When drinking and for stabilizing wine products, also in the use of less than 1.0 wt. In all coal and other industries that require the use of water, very large particles are obtained. which are formed by gold nanoparticles. Таблиця З нкнкжжананаананалалєллллалатиаИаааааааананнтанннннни, ІНН У ин ііі півнів іінінівнік 1 й З 4 В і Вуглеводи ВО 45 1 З 05 і Бодазвбоводноспиртовий розчин 0000 рештв о 0ремтае решта 000 решта НЯ Міністерство вовіти і мауки України Державний депвртамант інтапектуальної впасності, вут. Urytskogo, 45, m. Kyiv, MET, OO, Ukraine SE SUkUkrainian Institute of Industrial Property, str. Glazunova, i, m. Kiy 45, OTO