UA87685C2 - Hetroaryl benzamide derivatives for use as glk activators in the treatment of diabetes - Google Patents

Hetroaryl benzamide derivatives for use as glk activators in the treatment of diabetes

Info

Publication number
UA87685C2
UA87685C2 UAA200612279A UAA200612279A UA87685C2 UA 87685 C2 UA87685 C2 UA 87685C2 UA A200612279 A UAA200612279 A UA A200612279A UA A200612279 A UAA200612279 A UA A200612279A UA 87685 C2 UA87685 C2 UA 87685C2
Authority
UA
Ukraine
Prior art keywords
het
ris
optionally substituted
membered
linked
Prior art date
Application number
UAA200612279A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Креиг Джонстоун
Даррен Маккерречер
Курт Гордон Пайк
Майкл Джеймс Воринг
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of UA87685C2 publication Critical patent/UA87685C2/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of Formula (I) wherein: Ris hydroxymethyl; Ris selected from -C(O)NRR, SONRR, S(O)Rand HET-2; HET-1 is a 5- or 6-membered, optionally substituted C-linked heteroaryl ring; HET-2 is a 4-, 5- or 6-membered, C- or N-linked optionally substituted heterocyclyl ring; Ris selected from halo, fluoromethyl, difluoromethyl, trifluoromethyl, methyl, methoxy and cyano; Ris selected from for example hydrogen, optionally substituted (l-4C)alkyl and HET-2; Ris hydrogen or (1 -4C)alkyl; or Rand Rtogether with the nitrogen atom to which they are attached may form a heterocyclyl ring system as defined by HET-3; HET-3 is for example an optionally substituted N-linked, 4, 5 or 6 membered, saturated or partially unsaturated heterocyclyl ring; p is (independently at each occurrence) 0, 1 or 2; m is 0 or 1; n is 0, 1 or 2; provided that when m is 0, then n is 1 or 2; or a salt, pro drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.(I)
UAA200612279A 2004-06-05 2005-06-01 Hetroaryl benzamide derivatives for use as glk activators in the treatment of diabetes UA87685C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0412602.5A GB0412602D0 (en) 2004-06-05 2004-06-05 Compounds

Publications (1)

Publication Number Publication Date
UA87685C2 true UA87685C2 (en) 2009-08-10

Family

ID=32696738

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200612279A UA87685C2 (en) 2004-06-05 2005-06-01 Hetroaryl benzamide derivatives for use as glk activators in the treatment of diabetes

Country Status (4)

Country Link
CN (1) CN101018773A (en)
GB (1) GB0412602D0 (en)
UA (1) UA87685C2 (en)
ZA (1) ZA200610140B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120120204A (en) * 2009-12-11 2012-11-01 아스텔라스세이야쿠 가부시키가이샤 Benzamide compound

Also Published As

Publication number Publication date
CN101018773A (en) 2007-08-15
GB0412602D0 (en) 2004-07-07
ZA200610140B (en) 2009-03-25

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UA87685C2 (en) Hetroaryl benzamide derivatives for use as glk activators in the treatment of diabetes