UA86947C2 - Method for the production of losartan - Google Patents

Method for the production of losartan

Info

Publication number
UA86947C2
UA86947C2 UAA200603282A UAA200603282A UA86947C2 UA 86947 C2 UA86947 C2 UA 86947C2 UA A200603282 A UAA200603282 A UA A200603282A UA A200603282 A UAA200603282 A UA A200603282A UA 86947 C2 UA86947 C2 UA 86947C2
Authority
UA
Ukraine
Prior art keywords
formula
production
tetrazol
biphenyl
hydroxymethyl
Prior art date
Application number
UAA200603282A
Other languages
Russian (ru)
Inventor
Станислав Радл
Ян Стах
Ондрей Клецан
Original Assignee
Зентива А.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зентива А.С. filed Critical Зентива А.С.
Publication of UA86947C2 publication Critical patent/UA86947C2/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A method for the production of the potassium salt of 2-butyl-4-chloro-1-[[(2'-lH-tetrazol- 5-yl)-1,1'-biphenyl-4-yl] methyl]-5-hydroxymethyl-imidazole of formula III(III),characterized in carrying out the solvolysis of 2-butyl-4-chloro-1-[[2'-(1-trityl-lH-tetrazol-5-yl)-1,1'-biphenyl-4-yl] methyl]-5-hydroxymethyl-imidazole of formula IV(IV)in anhydrous methanol in a neutral or slightly basic medium and the reaction with an equivalent of a substance of formula MB where M is potassium, n takes values of 1 to 2, B is either CO- or HCO-.
UAA200603282A 2003-08-27 2004-08-26 Method for the production of losartan UA86947C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ20032319A CZ297016B6 (en) 2003-08-27 2003-08-27 Method for removing triphenylmethane protecting group from 1-trityl-5-(4'-substituted aminomethyl-1,1' -biphenyl-2-yl)-1H-tetrazoles and process for preparing losartan, irbesartan and valsartan potassium salt by making use thereof

Publications (1)

Publication Number Publication Date
UA86947C2 true UA86947C2 (en) 2009-06-10

Family

ID=34384005

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200603282A UA86947C2 (en) 2003-08-27 2004-08-26 Method for the production of losartan

Country Status (2)

Country Link
CZ (1) CZ297016B6 (en)
UA (1) UA86947C2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ298471B6 (en) * 2004-05-19 2007-10-10 Zentiva, A.S. N-[(2?-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-(L)-valine benzyl ester salts and their use for preparing valsartan

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270317A (en) * 1990-03-20 1993-12-14 Elf Sanofi N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
ATE194603T1 (en) * 1994-01-28 2000-07-15 Takeda Chemical Industries Ltd A PROCESS FOR PRODUCING TETRAZOLYL COMPOUNDS

Also Published As

Publication number Publication date
CZ20032319A3 (en) 2005-04-13
CZ297016B6 (en) 2006-08-16

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