UA86030C2 - Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof - Google Patents

Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof

Info

Publication number
UA86030C2
UA86030C2 UAA200602524A UAA200602524A UA86030C2 UA 86030 C2 UA86030 C2 UA 86030C2 UA A200602524 A UAA200602524 A UA A200602524A UA A200602524 A UAA200602524 A UA A200602524A UA 86030 C2 UA86030 C2 UA 86030C2
Authority
UA
Ukraine
Prior art keywords
methods
benzoxazole
preparation
sulfonamide compounds
intermediates
Prior art date
Application number
UAA200602524A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Кок Херман Аугустінус Де
Уолтер Фердінанд Марія Філліерс
Уім Альберт Алекс Елтерман
Original Assignee
Тіботек Фармасьютікелз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тіботек Фармасьютікелз Лтд. filed Critical Тіботек Фармасьютікелз Лтд.
Publication of UA86030C2 publication Critical patent/UA86030C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The present invention relates to methods for the preparation of benzoxazole sulfonamide compounds of formula (9) as well as novel intermediates of formula (6) for use in said method. More in particular the invention relates to methods for the preparation of 2-amino-benzoxazole sulfonamide compounds which make use of 2-mercapto-benzoxazole sulfonamide intermediates, more in particular methods employing the intermediate [-benzyl-2-hydroxy-3-[isobutyl(2-methylsulfanyl-benzoxazole-6-sulfonyl)-amino)-propyl)-carbamic ester, and to methods amenable to industrial scaling up. Said benzoxazole sulfonamide compounds arc particularly useful as HIV protease inhibitors. The substituents are defined in the claims.
UAA200602524A 2003-09-30 2004-09-30 Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof UA86030C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03103630 2003-09-30

Publications (1)

Publication Number Publication Date
UA86030C2 true UA86030C2 (en) 2009-03-25

Family

ID=34924109

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200602524A UA86030C2 (en) 2003-09-30 2004-09-30 Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof

Country Status (1)

Country Link
UA (1) UA86030C2 (en)

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