UA83050C2 - Method for assessment of abnormality of current distribution in heart - Google Patents

Abstract

The invention relates to medicine, namely to cardiology, and regards a method for assessment of abnormality of current distribution in a heart by performing of magnetocardiographic mapping and inverse problem solution with the calculation of vectorial maps of distribution of current density, reflection of current intensity, vector depth, by the visual analysis of separate noncommunicative areas of current and whirlwinds of current, detection of standard map. At that on this map the amount of separate areas are calculated and their indexes are qualitativedetermined, namely - direction, co-ordinates and intensity, and also intensity and form of the indicated whirlwinds, the difference degree of the indicated indexes from the such in a standard map are determined by a 4-point scale and on this base the abnormality degree of current distribution in a heart in a present cardiocycle is determined, and the assessment is made with the use of the program and reflection on the computer monitor.

Description

(51) IPC (2006) ea db1B 5/02

In Ab1Vv 5/0436 (2006.01)

MINISTRY OF EDUCATION

AND SCIENCES OF UKRAINE

STATE DEPARTMENT OP AND S

INTELLECTUAL RIGHTS TO THE PATENT FOR THE INVENTION

PROPERTIES of the bus (54) METHOD OF ASSESSMENT OF ABNORMALITY OF CURRENT DISTRIBUTION IN THE HEART 1 2 (21) a200600584 calized areas of the current - zones with the main vector (22) 01.23.2006 torus, which has a local maximum (46) 06.10.2008, Bull. Meo 11 , 2008 intensity and surrounded by vectors of shorter length (72) TCHAIKOVSKY ILYA ANATOLIYOVYCH, PA, and current vortices - zones with closed loops

BUDNYK MYKOLA MYKOLAYOVYCH, OA with bundles of vectors, establishing a reference car- (73) INSTITUTE OF CYBERNETICS NAMED V. M. GLUSHKOVA, when there are two symmetric vortices and one

NAS OF UKRAINE, SHA, INTERNATIONAL SCIENTIFIC (dipole) section of maximum intensity,

EDUCATIONAL CENTER OF INFORMATION TECHNOLOGY is placed in the middle of the map and directed to

LOGIY AND SYSTEMS OF NAN AND MON OF UKRAINE, PA, sleep of the heart left-down, which differs in that

TCHAIKOVSKY ILYA ANATOLIYOVYCH, SHA, BUD - calculate the number of individual parts on this map

NIK MYKOLA MYKOLAYOVYCH, OA nok and qualitatively determine their indicators, namely - (56) UUO 0217769 A2, 03.07.2002 direction, coordinates and intensity, as well as inte-

Budnyk M.M., Voytovych I.D., Kozlovskyi V... and others. / strength and shape of the specified vortices, set

Diagnostic criteria of chronic ischemic disease are the degree of difference of the indicated indicators from the heart based on registration and analysis of magnetic maps in the reference map on a 4-digit scale, with diagrams // Prep. NAS of Ukraine. Institute of Cybernetics, this small degree occurs with asymmetry named after V.M. Glushkov.-2002.-Me5-49p. choirs, when there is uneven intensity and

OZ 2005/0192502 JSC, 01.09.2005 difference in shape from oval, medium degree -

TvyKada K., Miuaz pa T., Kapaoi A. ei ai. / Ap iso- when the direction and coordinates of the dipole section are removed from the reference map, a large degree - Z. tadpeysagaidgat, apa iB will break up the available additional sections of the current, very large d) diadposiv oyi izspetis Neagi divease // Ipi . in). Saga. degree - the direction or coordinates of all sections of the line segment

Itadipo.-2000.-Reb.;16(1).-R.55-66 avoid such in the reference map so that there is no

UR 2002153436, 28.05.2002 easily detect the dipole section of the current, and on this (57) Method of assessing the abnormality of the current distribution, they draw a conclusion about the degree of abnormalities in the heart by performing magnetocardiography of the distribution of currents in the heart at the moment of short mapping and solving the inverse problem from the dicycle, and the evaluation itself is performed using the calculation of vector maps of the density distribution of the program and display on the monitor of the current, display of the current intensity on the computer. with vector weight, visual analysis of individual salmon

The invention belongs to medicine, namely to coronary heart disease (CHD) because "diology and can be used for diagnosis. Similar changes can occur in other disorders of electrophysiology and other myo-pathologies. Predictive value of load and card. general tests (cycle ergometry) and form methods

Today, the reliable diagnosis of the majority of feeding medical images (MR and computer imaging of pathological diseases remains a clinical tomography, echocardiography, ultrasound intro- topical problem. The reasons lie in toscopy) is often limited from the point of view of information and that other instrumental methods of diagnosis on electrophysiological processes in the myocardium. Various have certain disadvantages. Thus, the electrocardiogram, manit stress tests, invasive methods (through the electrocardiogram (ECG) at rest is often normal, and the changes are input electrocardiogram) and methods that are not specific enough for some pathologies are based on the introduction of contrast agents, for example to such widespread and dangerous (coronary angiography, radionuclide methods)

fear is accompanied by a certain risk for pacific- division of currents in the heart (inverse task (03) magni- ents, and therefore cannot be carried out as often as tostatics) because different tissues of the human body need it |see. Vinogradova T.S., Akulova F.D., practically magnetically homogeneous | see Diagnostic

Belotserkovsky 3.B. et al., Instrumental criteria of chronic ischemic heart disease for the purpose of research of the cardiovascular system of registration and analysis of magnetocardiograms I! Building topics - M.: Medicine, 1986. - 41bs.|. nyk M., Voytovych I., Kozlovskyi V. and others. / 2002. -

Most methods of diagnosis of diseases Prof. NAS of Ukraine. Institute of Cybernetics named after V.M. hearts relate to certain pathologies and use - Hlushkova; Mo 5. - 49s.|. certain instrumental methods are used. However, a number of patents are known that are based on the development of methods capable of evaluating the ability of the ICG to give new useful information about the functional state of the heart in general. This should serve as markers of the presence of certain diseases, as well as for the detection of diseases in the early stages of electrophysiological processes in the heart. and for the purpose of automated computer 1. CA 40410A, Method of forecasting the frequency of ECG processing. occurrence of spontaneous paroxysmal flickering

Yes, in patent KO 2067417 | Malaya L.T. etc. of arrhythmias, Chervonopyska O., Stadnyuk L., Chai- "Method of assessing the functional state of the heart Serdkovskyi I. et al., Byul. Mo 6, 2001. (Institute of Cardiology named after Tsa", 1996) the generalized diagnostic M.D. Strazheska). criterion, the value of which is "0.4 or 20.6 times 2. SHA 40411А, The method of forecasting will preserve the conclusion about the presence of sinus rhythm disorders with paroxysmal dysfunction of the heart's functional state. However, the specified criterion of my atrial fibrillation, Stadnyuk L., Chervonopys- applies morphological analysis of the ECG with quantitative ka O., Tchaikovsky I. and others, ibid. calculation of amplitude-time indicators, and 3. SHA 53455А, The method of diagnosing myocardial infarction, the ECG method is not specific enough in a number of za- Okard, Stadniuk L., Kozlovskyi V., Budnyk M., diseases, especially in the early stages. Nizhenkovskyi I., Byul. Mo1, 2003. (Institute of cardio-

In addition, fully automated methods of logy named after M.D. Strazheska). analysis of electrical activity today does not have a sufficient level of reliability. In this connection of the myocardium, Voytovych I., Kozlovskyi V., Stadniuk, visual analysis remains the main method. Li, Budnyk M., ibid. house for making a diagnostic conclusion on 5. OA 74466, Method of diagnosis of ischemic pain based on comparison with sets of standardized heart tests / Kozlovskyi V., Budnyk M., Stadnyuk of typical data summarized in atlases. LI, Ryzhenko T., Bull. May 12, 2005. Institute of Cardiology

Among the most promising diagnostic methods named after M.D. Strazheska). tive non-invasive, humane and safe methods that 6. UMO 0205713, Sapias tadpeis yeid aiiad- do not cause negative effects on humans, do not pogeg g agtgia! YaiCheg apa aitgia! YarpiPakop apa teysa have contraindications, and therefore they can repeatedly og idepiyuipu eyesigis (Shtgpipd ra oi akgia! Yashbceg, repeated in various clinical situations, for example, 2002. for monitoring the effectiveness of medication- 7. MO 0217769, vspetiia idepnysayop, dpapkyznoi therapy or surgical intervention. In this connection, magnetocardiography (MKG) is a completely non-invasive and safe method, which, as shown - Patents OA 40410A and 40411A are related to diano in a number of studies, has additional information about the gnostics of the paroxysmal form of flickering ary- compared to the above methods | Sotriv-tmiya (MA) regarding the prediction of the frequency of parotepiag Myte oi Eesigo- apa Madpeyusagaiodgarnis xisms and preservation of sinus according to the rhythm

Oaia ip Rayepb myth Ivspetis Neagi Oizease /.. OA 40410A with the number of extremums 238, make

Iap 0. 5igoiipK, V. Moogaee ei ai. // 9. Eiestosagisi - a conclusion about the possibility of spontaneous odes, 1990, M.23, p.315-322). paroxysms of MA more than 6 times a year. If

The perspective of using ICG for diag- the number of extremums "38, then predict the possibilities of heart pathologies also lies in the fact that other methods of diagnosis do not allow to obtain months (ША 404114А). But these patents are based on the direction and magnitude of local currents in myocardium, on the analysis of magnetic field maps, and not on the distribution of currents. In principle, the distribution of the excitation potential of waves, which is more informative and can also be obtained using the potentiation method, is only for one disease. comprehensive mapping of the human body. However, OA Patents 53455A and 534564, taken as analogs, it is impossible to reconstruct the corresponding distribution of current gi, related to the diagnosis of myocardial infarction (MI) sources on this path. The reason for - and not - O MI. However, in patent PA 53456, it is considered that the distribution of electric potentials is the process of depolarization - wave 0. Patent OA on the surface of the body distorts heterogeneity and even 53455, although it considers the process of repolarization, the slusotropy of electrical conductivity of different layers of tissues and cells - interval 51-T (like the proposed invention), organs that are very different in the human body. In addition, the disadvantage of both patents is that they are related to the distribution of electrical conductivity in the volume of myocardium up to the severe stage of IHD, i.e. when the MI is already not precisely known, varies from person to person, which is usually accompanied by changes person and changes under the influence of heart pathologies. on the ECG, for example, a negative T wave.

In contrast, the non-invasive method of ICG In contrast to this, patent OA 74466 registers the magnetic field directly generated for the diagnosis of such forms of coronary heart disease, in which there are currents in the heart, allows to reconstruct the disruption of the repolarization process, but the form of the T wave on the ECG does not changes, and other changes on the ECG 7) it is assumed that the degree of difference is non-specific. However, it is also based on the analysis of these indicators from such dipole maps, magnetic field ratio maps, and not currents, and therefore cannot determine the degree of abnormality of the RGS in the heart, determine the localization and direction of pathological gener- 8) detected abnormality of the RGS in the heart can . not be caused by a specific disease, but by different ones

On the other hand, patent MO 0205713 protects cardiac pathologies. the method of detection of the trajectory of excitation in the myocardium. Also new compared to the prototype is that in case of ventricular fibrillation, it is based on O3. But that the proposed method is statistically confirmed - it is based on the dipole approximation, and therefore by the analysis carried out on the basis of ICG data - also cannot detect the localization of several representative groups of patients with different cardio- separate sources associated with pathological pro-logical diseases and of healthy volunteers in the myocardium and also applies only to individuals. her pathology. The dipole model does not allow to identify individual

In UMO patent 0217769, taken as a prototype, electrical sources in the myocardium, therefore necessary, consider a method of diagnosing CHD, in which CHD is more complex distributed models. Such a model is classified into 4 degrees according to the changes in ver- the representation of the source in the form of RGS maps in the tical coordinate (depth of occurrence) effective frontal plane that intersects the heart on a certain tive dipole during the 5I-segment. At this depth. The depth is calculated on the basis of the 1st (2nd, etc.) stage of ICH, if the depth of the zation procedure as the depth where the dipole is located varies only during the 1st simum current density. Therefore, this invention represents the (2nd, etc.) quarter of this segment. In healthy people, the in-depth solution of the inverse problem (03) does not change practically. The disadvantage of magnetostatics in the form of the distribution of currents in the indicated method-prototype is that: ntal plane. 1. OZ is solved in the approximation of the magnetic, not the RGS map in is a vector field, where the vectors of the current dipole, which is a physical abstraction and is placed on a regular, usually square grid that does not correspond to the electrophysiology of the heart. Each vector reflects a local value of 2. the dipole approximation cannot detect the current density at a given point, that is, the current density. Zones, in several sources, if such are present in the myocardium, whose vectors have local maxima and are surrounded by

C. there is no data on the reliability of such a classification - vectors of smaller amplitude are considered to be individualizations - i.e. data on the correlation of the specified current with areas of electrical activity (current). coronary artery disease with the degree of ischemic myocardial damage. The proposed invention is based on the calculation based on the data of other instrumental methods of assessing the degree of difference of RGS maps in the frontal plane diagnosis from the symmetric dipole 4. this method applies to the diagnosis of only the (reference) distribution. The specified difference in image

CHD and cannot be applied to the detection of other cardiac pathologies. of individual current regions as their number, on

Thus, the state-of-the-art analysis of lines, coordinates and intensity, and also showed that there is no method of analyzing intensity distribution maps and the shape of vortices surrounding them. of current density (RSD) in the myocardium, which would be able to The mathematical content of these indicators is to reveal the abnormal nature of the RGS, which means that the direction, coordinates, and intensity of the corresponding parameters in the patents listed by them, yes and no. What is new about the main vector of this area, which is the method vector compared to the current level, is that: the largest length. The physical meaning of the regions and 1) for the analysis of electrophysiological processes in vortices is that they reflect the heart, not the parameters of the local zone on the RGS maps, in which the source (area) dipole is increased, but the parameters of the distributed or reduced (vortices) current density in . source - a flat layer of RGS in the form of a two-dimensional gradient of the transmembrane potential, which 2) is analyzed as primary (active) generates primary currents. This zone is located in both secondary (volumetric, passive) currents in the myo-myocardium, which, from the point of view of electrodynamics, is the cardia, a conductive medium. Therefore, in the part of the myocardium

C) a quantitative and semi-quantitative assessment is carried out - outside the primary currents area, there are informative indicators of RGS maps, passive (secondary) currents. Normally, the myocardium has 4) the appearance of a reference RGS was found, namely, fairly uniform electrical conductivity, therefore a symmetrical dipole map that corresponds to the norm and primary currents are localized in one (main, describes the absence of abnormality, dipole) current region, and secondary currents are 5) the difference of indicators that hide the appearance of two symmetrical (that is, roughly characterize separate regions of primary currents of equal intensity) current vortices is determined. Thus, (quantity, direction, coordinates, intensity) from the electrical source of the heart in the norm in the first na- such as in the reference dipole (normal) map, the neighbors are a current dipole. b) the difference between indicators is determined, which The main idea of the invention is that on describe separate closed chains of vectors (based on the degree of difference of the indicated indicators from the chorus) of secondary currents (intensity, geometrical form of the dipole map) from such in the reference dipole (nor- about the possibility (presence) of an abnormality of the grinding) map, the division of currents in the heart and the degree of the specified abnormality

bearing The basis for the formulation of such conclusions. The technical result of improving the method is that the reason for the difference between the indicated values for the assessment of RGS abnormality in the heart is the presence of areas (vortices) of the current through the use of new actions, modes of execution of myocardial zones with different excitation conductivity, which are not actions, and empirically determined limits, indicators may appear as a result of pathological defects, namely: changes in electrophysiological processes in the myocardium, 1) classification of all types of deviations of the RGS map, for example, due to ischemia, inflammation or dis- from the reference dipole map, atrophy heart muscle. 2) selection of structures on the map to be analyzed -

The basis of the invention is the task of determining the areas and vortices of the method of assessing the abnormality of the distribution 3) choosing the indicators on the basis of which the currents in the heart are described, obtained on the basis of: the difference of the areas and vortices of this map from 1. carrying out ICG mapping, reference dipole map 2. solving inverse problem, 4) formulation of a 4-digit gradation scale 3. calculation of RGS vector maps, in which the degree of difference of this map from the reference current intensity is proportional to the length of the vector, the field map, 4. finding on maps the zones with the main vectors 5 ) the connection of selected indicators with electrophysiators that have a local current maximum and biological processes in the myocardium in normal conditions and when surrounded by vectors of shorter length (so-called cardiac pathologies, the current in certain localized areas), 6) the presence of experimentally examined 5. findings on the map of zones with closed la- groups of patients with cardiac diseases, strings of vectors (the so-called choir current y), verified by generally accepted methods 6. establishing the appearance of the reference map as diagnostics. maps with two symmetric vortices and one Brief description of the illustrations: a dipole region placed in the middle of the car Fig. 1 - Reference map of the RGS dipole structure, the main vector of which is directed in the direction: the main dipole area is surrounded by a solid line to the heart left-down ). line

The set task is achieved by: Fig. 2 - RGS map of the dipole structure with asymmetry, .3 - RGS map of the dipole structure with defo- 2. calculation of indicators (intensity and current vortices formed by current vortices (small degree of relaxation) current vortices, minity): a vertically elongated vortex is shaded 3. formulation of a 4-digit scale is semi-quantified gray of different grades (small, medium, large, very large Fig. 4A - Map of RGS dipole structure with anorak), small direction of the dipole (average degree of deviation). we are indicators of regions and vortices of this map and Fig. 5 - Map of RGS dipole structure with anorgradations of the degree of its difference from the reference one by minor coordinates (average degree of difference- map in the form: ness). 4.1. small degree - asymmetry of vortices (uneven Fig. b6 - RGS map of a dipole structure with anor- intensity and difference in the form of vortices from a small direction and asymmetric vortices oval), (medium degree of difference). 4.2. average degree - the direction and coordinates of the di- Fig. 7 - The RGS map of the non-dipole structure from the main region differ from those in the reference dipole region (solid line) of the normal map, the minor direction and two additional regions 4.3. a large degree - the presence of additional current lines (dashed lines) of lower intensity current areas (a large degree of difference). 4 A. a very large degree - the presence of several current, it is impossible to detect the dipole section of the current. (dotted line) of approximately equal intensity (high 5. definition according to this 4-digit scale of the degree of difference). the degree of difference of this map from the reference di- Fig. 9 - RGS map of the non-dipole structure from the field map. two current regions (dotted line) approximately equal

This makes it possible to ensure: new intensity and abnormal localizations 1. drawing a conclusion about the possibility of abnormal current areas (a very large degree of difference in the distribution of currents in the heart in this capacity). ment of the cardiocycle (with a small degree of difference), Fig. 10 - RGS map of a non-dipole structure with 2. making a conclusion about the presence of an approximate abnormality indicated by the three areas of the current (dotted line) and its degree (medium, large, of very equal intensity and large in the abnormal directions), and localizations of all areas of the current (a very large 3. making a conclusion using a compu- degree of difference). program with the display of the evaluation results. The proposed method involves carrying out an abnormality check on the display. ICG with simultaneous ECG registration in the 2nd standard lead. At the same time, K peak of the ECG is used

is used as a synchronizing strobe pulse for the types of deviations in order of increasing degree of fulfillment of the procedure of averaging the ICG signals, and the difference from the reference card. also for the selection of impulses of a certain ethnology and In the general case, pathological changes in myo- in the presence of several pacemakers. Then the provocations lead to increased heterogeneity and see several successive stages of data processing. anisotropy of the spatial distribution of conductivity.

First, pre-processing is carried out, in the case of a small difference in conductivity in the affected areas, as a result of which the ICG signals are cleaned from different layers of the myocardium, asymmetry and magnetic disturbances of man-made origin appear on the maps, which is the deformation of current vortices. Under the asymmetry, they break into the device during ICG registration. It has different intensity of the current (the length of the vector includes filtering, selection of complexes from im- tors that form a vortex). Deformation means pulse interference, selection and averaging of deviations from the oval geometric shape of cardiocycles. choirs of the reference map (Fig. 1). The reason for the asymmetry

Next, the reconstruction of the ICG maps is performed in (deformation) vortices, the appearance of myocardial zones with different squares of 20x20 cm above the patient's chest. by the magnitude (direction) of conductivity, i.e. non-identical

For further analysis, birth maps (anisotropy) are selected. during the 3rd interval, see: Budnyk M., Chai- Yes, Fig. 2 shows a map of the dipole strukovski |. Magnetic resonance imaging: analysis of data from a tour with asymmetric eddy currents. Here ver- the point of view of medical application. The methodical hnei vortex of secondary currents is weaker, because it instructions for masters - KNU named after Taras Shevchenko, formed by vectors of smaller amplitude. Mozhliva 2005. 52 p.|. These actions are generally similar to the actions, the physiological reason is that in the basal parts of the left ventricle, which are described in patents SHA 53455A, OA 53456A, UMO, the conduction of excited 0200108, OA 74466 and is not the subject of this fault is less due to effects of pathological factors. move Figure 3 shows an example of a dipole map

In the implementation of this invention, structures with deformed vortices of currents are used. sib solution of OZ according to UMO 0200108 | Sotrshetg- The vortex of secondary currents is from the right

Brazei tetoa yug ashotatcyisayu rgosezzipu daya, ev- boku and formed by vectors directed against resiayu tadpeyusagaiodgarnis daiga, oi Biotadpeis of the time arrow (shaded in gray). It can be seen that

Theid 5. 5. Kotapomisi, E.5ieiprego, ZOSHIU AS, Seg- it is stretched in longitudinal (vertical) tape, 2001), in which RGS maps are calculated in the direction compared to the norm. The probable cause of the frontal plane, and the vectors are placed on such a deformation of the vortex shape is that the 10x10 grid with a step of 4cm. that in the lateral parts of the left ventricle under action

Figure 1 shows the RGS map of the reference dipole - pathological factors present anisotropy of the conducting structure. This means that the card has: In this case, the indicated anisotropy is 1) only one main area with a maximum is that the conductivity in the vertical intensity of currents; direct movements of the front of the excitation wave (which is on map 2) the specified section is covered by two symmetric RGS coincides with the direction of the dipole, i.e. the main vortices of the current; of the current region) is increased. Another reason may 3) the specified area has a normal direction is that the conduction in the transverse left-down (on the patient's side, as is accepted in the electrical direction is reduced. Simultaneous action of trocardiology is also possible; on the map it is right-down); both of these factors. 4) the specified area is located approximately in the middle of the map. stem deviation, because such changes take place only

Maps of healthy volunteers, as a rule, are for eddies, that is, secondary currents. At the same time, a homogeneous (homogeneous) distribution is shown, the distribution of primary currents does not differ from the currents, that is, the RGS maps are characterized by normal properties, that is, the main excitation has dipole properties 1)-4). Thus, the reference dipole character. The main parameters of the current map have only one main dipole section of the dipole are the direction and localization (coordinates). With the current, which is covered by symmetrical vortices, greater degrees of pathological changes in the myocardium, the vka- is located approximately in the center and is directed to the parameters differ from those in the normal- to the left-down. noy map (Fig. 1).

From the point of view of human electrophysiology, this is Yes, Fig. A shows a map of the dipole structure - means that the electrical generator of the heart during the tour with an abnormal right-down direction, and on repolarization there is a distributed source, localized - Fig. 5 - a map of the RGS dipole structure of an abnormal within the limits of the zone where there is electrical excitation of localization, where the section of the current is shifted to the left-downward of the myocardium. The boundary that separates excited and non-excited compared to the norm. The physiological cause of such geni zones is the front of the wave of excitement. In the case of repo-differences of the maps, it is that the degree of polarization of the ventricles, this front is already greater in the norm of pathologic lesions of the myocardium, which is taken to the left-down. leads to a medium degree of heterogeneity and

Deviation from the map, which has the properties of 1) - anisotropy between different departments of the myocardium. 4). that is, the appearance of several additional ventricles. At the same time, similarly to the ECG, the number of pathological changes in the knock-on areas of the current with different directions is proportional to the angle of the main vectors. Figures 2-10 show the difference between the direction of the current dipole in this map and in the norm (left-down). Anomalous localization of the excitation dipole on three separate, approximately equal amplitudes in Fig. 5 can be explained by the average of unequal fronts. conductivity, in which the conductivity in the lateral In Fig. 9-10, all regions of the current are equal and sections of the left ventricle is increased, therefore, abnormal localization or direction will occur, and the distribution is shifted in this direction. there is no normal excitement. that means

With even greater differences in conductivity, the excitation wave front is very strongly deformed in the affected zones from the norm, the excitation wave front is bent and splits into two or three equal parts. It will be deformed up to its complete separation, so the excitation is completely delocalized by the burst into several fronts, i.e. with are added and has a fragmentary character. Pathological fronts are present on the RGS maps. On the RGS maps, there will be two or three areas of the current that have the appearance of a dipole pattern, while representing a strong heterogeneity (inhomogeneity) of several types of deviations at the same time (average excitation. degree of abnormality) or to a non-dipole. Thus , the proposed method gives the possibility of structure, i.e., before the appearance of additional areas, based on the comparison of RGS maps in healthy currents (high degree of abnormality). (Fig. 1) and in patients with cardiac pathologies (Fig. 2-

Thus, in Fig. b (average degree of abnormality) 10) to draw a conclusion about the possibility (Fig. 2-3) or a map is given where there is a combination of two presence (Fig. 4-10) of abnormality in the distribution of types of deviations from the reference picture - asymmetry of currents in hearts vortices and anomalous direction of the dipole region. Therefore, the given implementation demonstrates the ability Here, the upper right vortex has a lower intensity of the proposed method based on degree, and the dipole is directed to the right-down. The asymmetry of this map from the reference dipole vortices can be explained by the smaller map to semi-quantitatively assess the degree of abnormality in the conductivity of the basal parts of the heart and/or the distribution of currents in the heart. Yes, the differences presented by the conductivity of the apical sections. Abnormal in Fig. 2-3 indicate a small degree, Fig. 4-6 - the direction of the current dipole is explained by the analog-normal, Fig. 7-8 - a large one, and Fig. 9-10 - a very large but Fig. 4. degree of abnormality.

The map in Fig. 7 (high degree of abnormality) The advantage of the proposed method is that it demonstrates the case of a non-dipole structure, but because it is not limited by a certain pathology, the difference from the dipole picture is minimal. Heart, and therefore can be applied (if available is that the main (dipole) section of computer programs or corresponding atlases has normal direction and localization, and add- maps for each pathology) to the analysis of the degree of ano - magnetic areas of the current (in the right-upper and left-normality of the distribution of currents in the heart, caused by mu-lower corners of the map) have a lower intensity due to various pathologies. ness than the main section. Such a map can be An additional advantage of the proposed approach is explained by the break of the front of the excitation wave, and there is a possibility of its application to the analysis of not only two additional weak fronts from anomalous RGS maps, but also magnetic field maps. In this case, in opposite directions, i.e. to the right and/or up. case, it is not necessary to solve the inverse problem,

With even greater differences in conductivity, instead of the current regions, the regions of the affected zones are analyzed from the normal wave front of the excitation of the magnetic field extrema. But the magnetic field can break into several separate areas, provides an indirect picture of the distribution of excitation, the intensity of which is approximately the same, and the tension of the myocardium, therefore, its informativeness for mok and/or localization may differ from the medical analysis is lower. norms Thus, the maps of Fig. 8 and Fig. 9 demonstrate non- The advantages of this approach also include a dipole structure, where there are two areas of the current, that it is oriented towards the use of cheap, approximately equal intensity. Such cards can be a small-channel magnetocardiograph. For example, in this implementation, a device with 4 MCG on two separate fronts of approximately equal size was used to generate the excitation wave caused by the front break. channels, able to examine patients in conditions

The difference between Fig. 8 and Fig. 9 is that a normal clinic without the use of a magnetic screen - that in Fig. 8 (high degree of abnormality) is one of the bathrooms. This lowers the cost of the survey, areas of the current still have signs of normal operation, which is especially relevant in the conditions of Ukraine. jinn The main section in Fig. 8 (encircled with a dashed line) has a normal direction and is partially described for the purpose of illustration. It is clear that in practice, people experienced in cardiology and anal- the direction opposite to normal. In contrast to the analysis of the ICG data, some changes and modifications can be made to the distribution of RGS in Fig. 9 (a very large degree of cation, for example, another time interval of cardiac abnormality) has more significant pathological features, other options for combining different types of ki, and namely - none of the areas has signs of normal deviations from the reference map (normal spacing, therefore, it is impossible to indicate the main area (division), bring into consideration a larger (than three) number of sources). current regions, apply the one described in the invention

In Fig. 10 shows an example of a map that is significantly different from the method for evaluating maps of the distribution of the magnetic field and the dipole structure, where there are as many as three regions, etc. However, we believe that the specified changes and mod- current are of approximately equal intensity. Such fication maps are those made without significant deviations that may be caused by the break of the laziness wave front from this invention, and therefore they are subject to the scope of this invention.