UA7031A1 - METHOD OF OBTAINING PLEUROMUTILIN DERIVATIVES OR THEIR HYDROCHLORIDES - Google Patents
METHOD OF OBTAINING PLEUROMUTILIN DERIVATIVES OR THEIR HYDROCHLORIDESInfo
- Publication number
- UA7031A1 UA7031A1 UA3857485A UA3857485A UA7031A1 UA 7031 A1 UA7031 A1 UA 7031A1 UA 3857485 A UA3857485 A UA 3857485A UA 3857485 A UA3857485 A UA 3857485A UA 7031 A1 UA7031 A1 UA 7031A1
- Authority
- UA
- Ukraine
- Prior art keywords
- hydrochlorides
- obtaining
- pleuromutilin
- derivatives
- pleuromutilin derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение относится к полициклическим соединениям, в частности к получению производных плевромутилина ф-лы где R1-C1-C6-аминоалкил, или их гидрохлоридов, которые проявляют антимикробную активность. Цель - получение более активных соединений. Получение ведут реакцией соответствующего замещенного амина со сложным эфиром соединения ф-лы HOOCR2, где R2 - C1-С6-алкиламин, аминогруппа которого содержит чящитные группы (такую как С(О)ОС(СН3)3) при комнатной температуре, после удаления защитных групп целевой продукт выделяют в виде основания или его гидрохлорида. 2 табл.The invention relates to polycyclic compounds, in particular to the production of derivatives of pleuromutilin f-ly where R1-C1-C6-aminoalkyl, or their hydrochlorides, which exhibit antimicrobial activity. The goal is to get more active connections. The preparation is carried out by the reaction of the corresponding substituted amine with an ester of the compound f-ly HOOCR2, where R2 is a C1-C6-alkylamine, the amino group of which contains scaling groups (such as C (O) OC (CH3) 3) at room temperature, after removing the protective groups the target product is isolated in the form of a base or its hydrochloride. 2 tab.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843405632 DE3405632A1 (en) | 1984-02-17 | 1984-02-17 | Novel pleuromutilin derivatives, processes for their preparation, and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
UA7031A1 true UA7031A1 (en) | 1995-03-31 |
Family
ID=6227948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA3857485A UA7031A1 (en) | 1984-02-17 | 1985-02-15 | METHOD OF OBTAINING PLEUROMUTILIN DERIVATIVES OR THEIR HYDROCHLORIDES |
Country Status (5)
Country | Link |
---|---|
DD (1) | DD253616A5 (en) |
DE (1) | DE3405632A1 (en) |
SU (1) | SU1582985A3 (en) |
UA (1) | UA7031A1 (en) |
ZA (1) | ZA851190B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO331772B1 (en) * | 1996-07-04 | 2012-03-26 | Biochemie Gmbh | Veterinary use of a pleuromutiline derivative |
GB9614017D0 (en) * | 1996-07-04 | 1996-09-04 | Biochemie Gmbh | Organic compounds |
UY25225A1 (en) * | 1997-10-29 | 2000-12-29 | Smithkline Beecham Plc | PLEUROMUTILINE DERIVATIVES USEFUL AS ANTIMICROBIAL AGENTS |
EP1908750A1 (en) * | 2006-10-05 | 2008-04-09 | Nabriva Therapeutics Forschungs GmbH | Process for the preparation of pleuromutilins |
-
1984
- 1984-02-17 DE DE19843405632 patent/DE3405632A1/en not_active Withdrawn
-
1985
- 1985-02-15 DD DD85273318A patent/DD253616A5/en unknown
- 1985-02-15 ZA ZA851190A patent/ZA851190B/en unknown
- 1985-02-15 UA UA3857485A patent/UA7031A1/en unknown
- 1985-02-15 SU SU853857485A patent/SU1582985A3/en active
Also Published As
Publication number | Publication date |
---|---|
ZA851190B (en) | 1986-09-24 |
SU1582985A3 (en) | 1990-07-30 |
DE3405632A1 (en) | 1985-08-22 |
DD253616A5 (en) | 1988-01-27 |
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