UA7031A1 - METHOD OF OBTAINING PLEUROMUTILIN DERIVATIVES OR THEIR HYDROCHLORIDES - Google Patents

METHOD OF OBTAINING PLEUROMUTILIN DERIVATIVES OR THEIR HYDROCHLORIDES

Info

Publication number
UA7031A1
UA7031A1 UA3857485A UA3857485A UA7031A1 UA 7031 A1 UA7031 A1 UA 7031A1 UA 3857485 A UA3857485 A UA 3857485A UA 3857485 A UA3857485 A UA 3857485A UA 7031 A1 UA7031 A1 UA 7031A1
Authority
UA
Ukraine
Prior art keywords
hydrochlorides
obtaining
pleuromutilin
derivatives
pleuromutilin derivatives
Prior art date
Application number
UA3857485A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
БЕРНЕР Хайнц
Виплєль Херманн
Original Assignee
"Сандос АГ"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by "Сандос АГ" filed Critical "Сандос АГ"
Publication of UA7031A1 publication Critical patent/UA7031A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к полициклическим соединениям, в частности к получению производных плевромутилина ф-лы где R1-C1-C6-аминоалкил, или их гидрохлоридов, которые проявляют антимикробную активность. Цель - получение более активных соединений. Получение ведут реакцией соответствующего замещенного амина со сложным эфиром соединения ф-лы HOOCR2, где R2 - C1-С6-алкиламин, аминогруппа которого содержит чящитные группы (такую как С(О)ОС(СН3)3) при комнатной температуре, после удаления защитных групп целевой продукт выделяют в виде основания или его гидрохлорида. 2 табл.The invention relates to polycyclic compounds, in particular to the production of derivatives of pleuromutilin f-ly where R1-C1-C6-aminoalkyl, or their hydrochlorides, which exhibit antimicrobial activity. The goal is to get more active connections. The preparation is carried out by the reaction of the corresponding substituted amine with an ester of the compound f-ly HOOCR2, where R2 is a C1-C6-alkylamine, the amino group of which contains scaling groups (such as C (O) OC (CH3) 3) at room temperature, after removing the protective groups the target product is isolated in the form of a base or its hydrochloride. 2 tab.

UA3857485A 1984-02-17 1985-02-15 METHOD OF OBTAINING PLEUROMUTILIN DERIVATIVES OR THEIR HYDROCHLORIDES UA7031A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843405632 DE3405632A1 (en) 1984-02-17 1984-02-17 Novel pleuromutilin derivatives, processes for their preparation, and their use

Publications (1)

Publication Number Publication Date
UA7031A1 true UA7031A1 (en) 1995-03-31

Family

ID=6227948

Family Applications (1)

Application Number Title Priority Date Filing Date
UA3857485A UA7031A1 (en) 1984-02-17 1985-02-15 METHOD OF OBTAINING PLEUROMUTILIN DERIVATIVES OR THEIR HYDROCHLORIDES

Country Status (5)

Country Link
DD (1) DD253616A5 (en)
DE (1) DE3405632A1 (en)
SU (1) SU1582985A3 (en)
UA (1) UA7031A1 (en)
ZA (1) ZA851190B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO331772B1 (en) * 1996-07-04 2012-03-26 Biochemie Gmbh Veterinary use of a pleuromutiline derivative
GB9614017D0 (en) * 1996-07-04 1996-09-04 Biochemie Gmbh Organic compounds
UY25225A1 (en) * 1997-10-29 2000-12-29 Smithkline Beecham Plc PLEUROMUTILINE DERIVATIVES USEFUL AS ANTIMICROBIAL AGENTS
EP1908750A1 (en) * 2006-10-05 2008-04-09 Nabriva Therapeutics Forschungs GmbH Process for the preparation of pleuromutilins

Also Published As

Publication number Publication date
SU1582985A3 (en) 1990-07-30
ZA851190B (en) 1986-09-24
DE3405632A1 (en) 1985-08-22
DD253616A5 (en) 1988-01-27

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