UA49003C2 - Method of draft of menthyl ether of isovaleric acid. - Google Patents

Method of draft of menthyl ether of isovaleric acid.

Info

Publication number
UA49003C2
UA49003C2 UA98074011A UA98074011A UA49003C2 UA 49003 C2 UA49003 C2 UA 49003C2 UA 98074011 A UA98074011 A UA 98074011A UA 98074011 A UA98074011 A UA 98074011A UA 49003 C2 UA49003 C2 UA 49003C2
Authority
UA
Ukraine
Prior art keywords
isovaleric acid
menthyl ether
draft
menthol
catalyst
Prior art date
Application number
UA98074011A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Володимир Васильович Трофіменко
Владимир Васильевич Трофименко
Марк Григорович Мордсон
Марк Григорьевич Мордсон
Нінель Юріївна Фрішман
Original Assignee
Державне Підприємство Завод Хімічних Реактивів Науково-Технологічний Концерн "Інститут Монокристалів " Національної Академії Наук України
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Державне Підприємство Завод Хімічних Реактивів Науково-Технологічний Концерн "Інститут Монокристалів " Національної Академії Наук України filed Critical Державне Підприємство Завод Хімічних Реактивів Науково-Технологічний Концерн "Інститут Монокристалів " Національної Академії Наук України
Priority to UA98074011A priority Critical patent/UA49003C2/en
Priority to RU99101027/04A priority patent/RU2153488C1/en
Publication of UA49003C2 publication Critical patent/UA49003C2/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

The invention relates to organic chemistry and may be used in chemicopharmaceutical industry, especially, for production of medication "Validol" that represents 25-30 percent solution of menthol in menthyl ether of isovaleric acid. Easy and ecological method is elaborated, which provides for high quality of menthyl ether of isovaleric acid (amount of admixture not more than 1 percent). Method includes reaction of menthol with isovaleric acid in presence of a catalyst. As a catalyst n-toluene sulfonic acid is used, molar ratio of above mentioned components is equal to 1,0:1,08 ( 1,1:0,015 ( 0,03 accordingly, process is made at the temperature of 105-125 °C with simultaneous distillation of water in the form of azeotrope mixture with isovaleric acid.
UA98074011A 1998-07-22 1998-07-22 Method of draft of menthyl ether of isovaleric acid. UA49003C2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
UA98074011A UA49003C2 (en) 1998-07-22 1998-07-22 Method of draft of menthyl ether of isovaleric acid.
RU99101027/04A RU2153488C1 (en) 1998-07-22 1999-01-18 Method of preparing menthyl isovalerate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
UA98074011A UA49003C2 (en) 1998-07-22 1998-07-22 Method of draft of menthyl ether of isovaleric acid.

Publications (1)

Publication Number Publication Date
UA49003C2 true UA49003C2 (en) 2002-09-16

Family

ID=21689287

Family Applications (1)

Application Number Title Priority Date Filing Date
UA98074011A UA49003C2 (en) 1998-07-22 1998-07-22 Method of draft of menthyl ether of isovaleric acid.

Country Status (2)

Country Link
RU (1) RU2153488C1 (en)
UA (1) UA49003C2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2626978C1 (en) * 2016-03-10 2017-08-02 Открытое акционерное общество "Ирбитский химико-фармацевтический завод" Method of producing validol

Also Published As

Publication number Publication date
RU2153488C1 (en) 2000-07-27

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