Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Александр Викторович Стадниченко, Юрий Михайлович КраснопольскийfiledCriticalАлександр Викторович Стадниченко
Priority to UAU200812064UpriorityCriticalpatent/UA40072U/en
Publication of UA40072UpublicationCriticalpatent/UA40072U/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
A method for obtaining of liposomal preparation comprises the obtaining of phosphatidylcholine film in a vacuum with the subsequent dispergation with the buffer solution. The dispergation of phosphatidylcholine film is performed in protogenic buffer solution at рН 2.5-5.5 with the subsequent obtaining of liposomes by extrusion. The buffer solution round the liposomes is replaced with the buffer solution on the base of sodium chloride and twice-substituted sodium phosphate at рН 6.0-7.5. An active substance is loaded, and a off-duty substance is removed by an ultrafiltration or ion-exchange chromatography (if necessary). A stabilizator (in the case of liquid liposomal form) or crioprotector (in the case of lyophilized liposomal form) is added. A sterile filtration is carried out and obtained drug is butylated with subsequent lyophilization (in the case of lyophilized forms).
UAU200812064U2008-10-132008-10-13Method for obtaining of liposomal preparation
UA40072U
(en)
PROCESS FOR THE PREPARATION OF UNILAMELLAR LIPOSOMES OF COARSE DIAMETER, THEIR PHARMACEUTICAL APPLICATION FOR ENCAPSULATION OF ACTIVE PRINCIPLE FOR DELAYED DELIVERY OF DRUGS AND DEVICE THEREOF.