UA36558U - Process for the hexapeptide preparation - Google Patents

Process for the hexapeptide preparation

Info

Publication number
UA36558U
UA36558U UAU200808186U UAU200808186U UA36558U UA 36558 U UA36558 U UA 36558U UA U200808186 U UAU200808186 U UA U200808186U UA U200808186 U UAU200808186 U UA U200808186U UA 36558 U UA36558 U UA 36558U
Authority
UA
Ukraine
Prior art keywords
arg
spg
tyr
peptides
purification
Prior art date
Application number
UAU200808186U
Other languages
Russian (ru)
Inventor
Александр Викторович Стадниченко
Юрий Николаевич Бовдуй
Original Assignee
Александр Викторович Стадниченко
Юрий Николаевич Бовдуй
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Александр Викторович Стадниченко, Юрий Николаевич Бовдуй filed Critical Александр Викторович Стадниченко
Priority to UAU200808186U priority Critical patent/UA36558U/en
Publication of UA36558U publication Critical patent/UA36558U/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Peptides Or Proteins (AREA)

Abstract

A process for the preparation of hexapeptide of formula Tyr-d-Ala-Gly-Phe-Leu-Arg by peptide synthesis in solution provides for stage-to-stage peptide elongation by connection in specified sequence of protected or unprotected amino acids or peptides followed by removal of provisional protective groups after each stage of connection, isolation and purification of intermediate peptides, repeating the process up to obtaining completely protected hexapeptide, removal of all protective groups, isolation and chromatographic purification of final peptide. In the peptide elongation process intermediate peptides of general formula Вос-AA...AA-CPG, wherein АА...АА is a chain of from two to six adjacent amino acid residues from the sequence Tyr(SPG)-d-Ala-Gly-Phe-Leu-Arg(SPG), wherein Tyr(SPG)=Туr, Tyr(Bzl), Arg(SPG)=Arg, Arg(NO), CPG=OMe, Onbz. One of protective groups Boc or CPG can be absent. Combination of protected amino acids or peptides is carried out by carbodiimide method, and addition of unprotected arginine by means of diphenyl phosphoryl azide. The purification of intermediate peptides is carried out by extraction , recrystallization or, if necessary, by chromathography. The purification of the final peptide is carried out by recrystallization and by methods of reversed-phase chromatography, ion chromatography or by combination thereof.
UAU200808186U 2008-06-17 2008-06-17 Process for the hexapeptide preparation UA36558U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
UAU200808186U UA36558U (en) 2008-06-17 2008-06-17 Process for the hexapeptide preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
UAU200808186U UA36558U (en) 2008-06-17 2008-06-17 Process for the hexapeptide preparation

Publications (1)

Publication Number Publication Date
UA36558U true UA36558U (en) 2008-10-27

Family

ID=50730308

Family Applications (1)

Application Number Title Priority Date Filing Date
UAU200808186U UA36558U (en) 2008-06-17 2008-06-17 Process for the hexapeptide preparation

Country Status (1)

Country Link
UA (1) UA36558U (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA037430B1 (en) * 2018-04-18 2021-03-26 Пивипи Лабс Пте. Лтд Anti-viral immunotropic agent for treatment of arvi

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA037430B1 (en) * 2018-04-18 2021-03-26 Пивипи Лабс Пте. Лтд Anti-viral immunotropic agent for treatment of arvi

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