UA151071U - Reinforced antiseptic hydrogel bandage - Google Patents

Abstract

The reinforced antiseptic hydrogel bandage includes a substrate with a hydrogel applied to it containing an antiseptic drug, and the hydrogel bandage includes pectin and sodium alginate, plasticizers, preservative and disinfectant, and chlorhexidine bigluconate as an antiseptic drug 2, and a cotton or polypropylene reinforcement element is used as a substrate.

Description

1. The field of technology to which the useful model belongs.

The useful model belongs to the field of veterinary medicine, namely to reinforced antiseptic hydrogel dressings, and can be used in the clinical practice of complex treatment of postoperative wounds by mechanical debridement or dressings, both in the presence of an infectious and inflammatory process, and without it . 2. Level of technology.

Bandages are used to speed up the stages of wound healing. Bandages on the wound perform the following functions: adsorb exudate; isolate the wound from the surrounding environment; provide the best microclimate in the wound (availability of oxygen, humidity, pH, etc.).

Among bandages, the most common dressing material used in surgery is gauze - a natural cotton fabric that can absorb 10 times more liquid than its own weight and is characterized by a moderate drainage function and low cost of production.

In addition to gauze bandages, there are 5 main groups of modern dressing material: films, hydrogels, hydrocolloids, foams and alginates. The first three groups - films, hydrogels and hydrocolloids - belong to the type of dressing material that creates and maintains an optimal level of moisture in the wound cavity. In turn, the effect of foam and alginates is based on the absorption of excess moisture (Andreev, D.Yu. Sovremennense ranevnye pokrtiya. Ch. I / D.Yu. Andreev, B.A. Paramonov, A.M. Mukhtarova // Vestn. hirurgii im I.I. Grekova. - 2009. - T. 168, Mo. 3. - P. 98-102; Apape! I. Modiiyey zhopa agesvipa my rpuyu-papovigisiigei soaiyypud rgemepi 5iarpuiosossa! apa rzhendotopai! Bioiit aemeyurtepi / I. Apupei! // MapozsaIe Nezeagsp

Her enegv. - 2012. - Mine. 7. - R. 690.)

Disadvantages of the indicated groups of bandages include: gauze - lack of selectivity, high adhesiveness, a significant decrease in absorbent properties after 8-12 hours after application, adhesion to the wound surface and, accordingly, painful and traumatic) removal of the bandage, a long period of treatment ( Shablovskaya T.A. Modern approach to the complex treatment of purulent-necrotic diseases of soft tissues /T.A. Shablovskaya, D.N. Panchenkov // Herald of experimental and clinical surgery - 2013. - T. MI, Me 4. - b. 498-507); films - contribute to the activation of the infectious inflammatory process in the wound, if there is one on the surface of the wound

Serous exudate accumulates and promotes skin maceration around the wound (dope5 M. M/oipa dgezzipa5 / M. dopev, U. E Stgeeu, K. a Nagaiipo. // VMO. - 2006. - Moi. 332-R. 777- 780); hydrogels and hydrocolloids - retain their absorbent capacity until the hydrocolloids are completely saturated with water molecules, at the same time they undergo strong deformation and need to be replaced; foam - the effect of drying the wound is manifested

Neaiipo aiopd m/yy Insteasez ip Nuaishtopap Zupinase Z apa RRAVo; Sepe Ehrgezviop ip Eridegtiv /

T. Matape, C. MaKadati, 5. Mo5pipo eyi aP / RiobBOpe. - 2013:8(8): pyre:/Loishttaiv.riov.ogad/ riozope/apisiye ?id-10.1371/oittai!.rope.00739 88).

The closest analogue to the claimed bandage is a hydrogel composition and dressings from it (patent KO 2157243 C1) for the treatment of wounds of various etiologies, burns of II and II degrees, stopping or stopping bleeding (hemostasis), especially when the composition is used in combination with a hemostatic agent, for example, thrombin, fibrinogen, etc., as well as for the prevention of the formation of keloid scars. The hydrogel composition contains acrylamide 0.005-4.8 and/or sodium acrylate 0-4.5, crosslinking agent 0.015-0.16, glycerin 1.5-2.5, propanediol 1.0-3.5, biologically active substances 0 -1.5, polyvinylpyrrolidone 0.1-0.5, water - other. The composition has sufficient adhesion to the skin and high biological activity. The dressing is made on the basis of the claimed hydrogel composition containing a substrate.

The claimed product and the prototype have significant common features: they include a substrate with a hydrogel composition containing an antiseptic drug applied to it.

The disadvantages of this product are that the composition has a weak degree of adhesion when applied to the wound surface, when it dries, it covers the wound with a film, it does not effectively absorb exudate from the wound in case of significant secretions, it is dangerous when the composition is fragmented, since acrylamide, when it gets into the blood, can provoke the development of non-plastic cells in the body processes.

The claimed remedy eliminates the shortcomings of the closest analogue, namely, a pectin-based reinforced bandage containing chlorhexidine isolates the wound surface from mechanical irritation and bacterial contamination, ensures water, air and heat exchange between the wound and the external environment, adsorbs excess exudate, maintains a moist environment and does not cause hyperosmotic damage and drying of the wound, stimulates the regeneration process, and in case of wound infection - inhibits the growth of microorganisms. Healing of a postoperative non-infected wound takes place under primary tension within 7 days without the formation of scar (516) tissue.

3. The essence of a useful model. 3.1. Essential features of a useful model.

The basis of a useful model is the task of developing an effective tool for the treatment of postoperative wounds by mechanical debridement, actually an antiseptic bandage made of hydrogel, impregnated with an antiseptic medicine - effective against pathogenic microorganisms and which includes elements of reinforcement and is convenient to use.

The technical result is achieved by the fact that the composition of the hydrogel dressing includes pectin and sodium alginate, plasticizers, a preservative and a disinfectant, and chlorhexidine bigluconate as an antiseptic drug, with the following ratio of components: 90: pectin (with a degree of esterification of 81.5 95) - 4.2-5.2; sodium alginate - 0.6-1.0; polypropylene glycol - 2000 - 1.4-2.0; polyethylene glycol - 4500 - 0.4-0.8; sodium benzoate - 0.05-0.1; polyhexamethyleneguanidine - 0.01-0.02; chlorhexidine bigluconate - 0.5-4.2; water - the rest (up to 100). At the same time, a cotton or polypropylene reinforcement element is used as a substrate.

The technical result of the method is due to the fact that cross-structured hydrogel plates are obtained, based on citrus pectin and sodium alginate, structured in a solution of calcium salts (chloride or gluconate, or citrate), using sodium benzoate as a preservative and polyhexamethyleneguanidine as a disinfectant, polyethylene glycol ( molecular weight 4500) and polypropylene glycol (molecular weight 2000) as plasticizers, and saturated with 2095 chlorhexidine solution and reinforced with cotton or polyethylene reinforcement elements.

Pectin is a polysaccharide of vegetable origin, consisting of residues of "-О0- galacturonic acid, a certain number of carboxyl groups of which are esterified with methanol. At the same time, the degree of esterification of pectin can be from 20 to 85 95. In the product claimed for the use of citrus pectin and sodium alginate as gel-forming polymers, the degree of esterification of pectin is achieved - 81.5 905. Such a hydrogel, with a high value of the modulus of elasticity, remains sufficiently elastic and the bandage made on its basis for closing postoperative wounds has high absorption properties and at the same time maintains a moist environment in the wound. In addition, it is known that pectin has pronounced antiseptic, hemostatic and detoxifying properties and is effectively used in the composition

From composite materials, ointments and films for wound treatment.

Pressing the plates to a thickness of 1-1.5 mm and using polypropylene or cotton reinforcement elements allow to increase their strength, and saturation with 20 95 chlorhexidine solution ensures manifestation of antiseptic properties of the bandage. After all, chlorhexidine as a medicine is successfully used against both gram-positive and gram-negative bacteria, yeasts and dermatophytes, and at the same time, as part of a hydrogel bandage, it does not cause a systemic effect on the body.

In this way, the provided information explains the technical result of the claimed product, confirms its effectiveness and objectivity. 3.2. Information that reveals the essence of a useful model.

When conducting a patent information search, the authors and the applicant found a technical solution (Hydrogel composition and dressings from it for the treatment of wounds of different etiology, patent KO 2157243 C1), which contains the largest number of essential features common to the claimed product and includes a substrate with applied a hydrogel composition containing an antiseptic medicinal product.

But the presence of the specified features common to the prototype is not enough to obtain the technical result that the claimed tool provides.

No technical solutions, which would completely coincide with the set of features that were declared, were found

In the patent and scientific and technical literature, no technical solutions were found, which would describe information about the features that distinguish the claimed product from the closest analogue and ensure the achievement of the technical result by the fact that the composition of the hydrogel bandage includes pectin and sodium alginate, plasticizers, preservative and disinfectant, and chlorhexidine bigluconate as an antiseptic medicine, with this ratio of components 90: pectin (degree of esterification 81.5 95) - 4.2-5.2; sodium alginate - 0.6-1.0; polypropylene glycol - 2000 - 1.4-2.0; polyethylene glycol - 4500 - 0.4-0.8; sodium benzoate - 0.05-0.1; polyhexamethyleneguanidine - 0.01-0.02; chlorhexidine bigluconate - 0.5-1.2; water - the rest (up to 100).

At the same time, a cotton or polypropylene reinforcement element is used as a substrate.

Therefore, the stated technical solution does not clearly follow from the state of the art. The useful model belongs to the field of veterinary medicine, namely to reinforced antiseptic hydrogel dressings, and can be used in the clinical practice of complex treatment of postoperative wounds by mechanical debridement or applying bandages, both in the presence of an infectious and inflammatory process, and without it . 4. Information that confirms the possibility of implementing a useful model. 4.1 Procedure for manufacturing the tool.

The claimed product is manufactured as follows: - a pectin hydrogel plate is prepared by mixing 8-12 95 of a solution of citrus pectin containing 0.02 95 of polygsamethyleneguanidine and 0.2-0.3 96 of sodium benzoate, with 3-4 95 of a solution of sodium alginate, 15 -20 96 PEG-4500 solution and 3.5-4.5 95 PPG-2000 solution in a ratio of 1:0.5:0.1:0.12; - 50-80 g of this mixture after complete homogenization is placed in a 10 cm x 10 cm x 10 cm mold with previously placed and spread sterile propylene or cotton mesh and layered with 800-120 g of 1 95 calcium chloride solution, kept for 20 hours. at room temperature; - the plate (4-6 mm thick) is removed from the mold, pressed to a thickness of 1-1.5 mm and saturated with 1-2 g of 20 95 solution of chlorhexidine bigluconate for 2 hours.

The effectiveness and advantages of the declared useful model are confirmed by examples of specific implementation. 4.2. Examples of specific use.

Example 1. To study the influence of a hydrogel pectin bandage with a content of 0.03-1.5 95 chlorhexidine bigluconate on the intensity of bacterial growth, nutrient media of the following composition were used for cultivation - 1 95 meat-peptone agar (MPA) with 4 95 glucose and to prepare the inoculum: 4 95 glucose with 1 95 meat-peptone broth (nutrient broth;

Pharmreaktiv LLC).

Media was prepared for research: the bottom layer - nutrient medium not inoculated with the test microorganism (approximately 20 ml per cup) and the top layer - inoculum; 10 ml of the suspension of the test microorganism was added to 100 ml of nutrient medium, mixed and poured 5 ml on top of the lower layer after it solidified (the temperature of the medium did not exceed 40-45790).

To prepare the inoculum, 5. ashgeiv or R. aegidiposa were transferred with a loop into a test tube with 10

3 ml of liquid nutrient medium and incubated for 24 hours. at a temperature of 3022 "C.

It was established that a hydrogel pectin bandage with a content of 0.03-4.5 95 chlorhexidine bigluconate inhibits the growth of both gram-positive (5. apygeiv) and gram-negative (P. aegidiposa) bacteria (Table 1). At the same time, regardless of the type of bacteria, the area (radius) of growth inhibition does not differ: at the minimum dose of chlorhexidine in the gel (0.03 95), the radius is 0.76-0.77 cm; for 0.4 95 - 0.90-0.92 cm and for the maximum dose (1.5 95) - 1.12-1.13 cm. Analysis of the dependence of the values of the radius of inhibition of bacterial growth on the dose of the active substance shows that a proportional increase in the content of chlorhexidine in the bandage growth inhibition is strong: for P. aegidipoza - p"-0.936 and 5. ashgeiyv - 12-0.859.

Table 1

Inhibition of the growth of microorganisms under the action of a hydrogel pectin bandage with chlorhexidine bigluconate, article, p-4; Mat geli, 96

Example 2. To confirm the effectiveness of an antiseptic bandage for the treatment of postoperative wounds, a pectin-based reinforced bandage with a cotton or polypropylene reinforcement element containing chlorhexidine bigluconate (0.4-1.5 U) was applied to the wound surface.

The bandage was applied to the postoperative wound in the area of the abdomen of cattle after laparotomy. The healing results were recorded for 7 days, daily.

It has been established that a pectin-based reinforced bandage with a cotton or polypropylene reinforcement element containing chlorhexidine bigluconate provides protection of the wound surface from contamination, mechanical irritation, bacterial contamination and the development of secondary infection. The bandage promotes good water, air and heat exchange between the wound and the external environment, adsorbs excess exudate, maintains a moist environment and does not cause hyperosmotic damage and drying of the wound. The use of a pectin-based reinforced bandage with a cotton or polypropylene reinforcement element containing chlorhexidine bigluconate ensures absorption of exudate and protection of the wound from contamination, irritation and injury by environmental factors.

At the same time, it was noted that during the period of wound healing, the bandage was well kept on the animal's body, and the healing of the postoperative wound took place under primary tension within 7 days.

Considering the method of application, this bandage is suitable for use in different parts of the animal's body (neck, withers, chest and abdominal walls, lower back, sacrum, thigh, shoulder, etc.).

The use of a pectin-based reinforced bandage with a cotton or polypropylene reinforcement element containing chlorhexidine bigluconate reduces the consumption of dressing material and ensures the cleanliness of the dressings during the wound healing period.

Thus, the research results obtained in the example of a specific implementation confirm the effectiveness of the tool.

Claims (2)

USEFUL MODEL FORMULA 1. Reinforced antiseptic hydrogel bandage, which includes a substrate with a hydrogel applied to it containing an antiseptic drug, which is distinguished by the fact that the composition of the hydrogel bandage includes pectin and sodium alginate, plasticizers, a preservative and a disinfectant, and chlorhexidine bigluconate as an antiseptic medicine, with this ratio of components, because: pectin (degree of esterification 81.5 95) 4.2-5.2 sodium alginate 0.6-1.0 polypropylene glycol 2000 1.4-2.0 polyethylene glycol 4500 0, 4-0.8 sodium benzoate 0.05-0.1 chlorhexidine bigluconate 0.5-12 polyhexamethyleneguanidine 0.01-0.02 water, the rest. 2. Reinforced antiseptic hydrogel bandage, which differs in that a cotton or polypropylene reinforcement element is used as a substrate.