UA140110U - METHOD FOR PREDICTING THE DEVELOPMENT OF OSTEOARTHRITIS - Google Patents

Abstract

The method of predicting the development of osteoarthritis includes clinical examination, radiography. Additionally, in the patient's serum determine the polymorphism of the nitric oxide synthase gene (eNOS T786C), the content of endothelin, folic acid, transforming growth factor beta 1 (TGF- (1), interleukin 6 (IL-6). endothelin> 10 ng / ml, folic acid <6 ng / ml, TGF-T1 <14 ng / ml, IL-6> 10 ng / l predict the development of osteoarthritis.

Description

The proposed useful model, Method of predicting the development of osteoarthritis, belongs to medicine, in particular to orthopedics and rheumatology, and can be used in the diagnosis of the development of osteoarthritis in the early stages.

Methods of predicting the development of osteoarthritis are known. These include x-rays, studies of biopsies of the synovial membrane, synovial fluid, and cartilage biopsies (Okorokov

A.N. Diagnosis of diseases of internal organs. - M., 2001. - Vol. 2. - P. 186-196). The disadvantage of these methods is the lack of the possibility of predicting the dynamics of the process in the early subclinical stages, preventing its development and possible complications due to the internal characteristics of the body.

The basis of a useful model is the task of developing a method that would allow predicting the development of osteoarthritis in the early stages.

The task is solved by the fact that, in addition to clinical examination and radiography, the polymorphism of the nitric oxide synthase gene (6eMOb5 17860), the content of endothelin, folic acid, transforming growth factor beta 1 (TGF-VDI1), interleukin 6 (IL-6) is determined in the patient's blood serum ) and with homozygous carrier 786-SS, levels of endothelin 210 ng/ml, folic acid "6 ng/ml, TFR-DV1 "14 ng/ml, IL-6 "10 ng/l predict the development of osteoarthritis.

Application of the method. During hospitalization, the patient is examined, x-rays are performed, the eMmo5 1786C gene polymorphism is determined, the content of endothelin, folic acid, TGF-B1, IL-6 is determined by the immunoenzymatic method. With homozygous carrier 786-SS and levels of endothelin 210 ng/ml, folic acid "b ng/ml, TFR-B1 "14 ng/ml, IL-b6 "10 ng/l predict the development of osteoarthritis.

A specific example of using the method

Patient Ch., 63 years old, went to the clinic for a pain syndrome in the right knee joint. X-rays were examined and performed. No signs of osteoarthritis were found. The eMO5 1786C gene polymorphism and the content of endothelin, folic acid, TGF-B1, and IL-6 were determined in the serum. A homozygous carrier of 786-SS was established, the levels of endothelin - 23 ng/ml, folic acid - 3.7 ng/ml, TFR-B1 - 7.8 ng/ml, IL-6 - 25 ng/l. The development of osteoarthritis was diagnosed. After 12 months, X-rays revealed signs of osteoarthritis.

Thus, the proposed method is informative and allows diagnosing development

From osteoarthritis in the early stages.

Claims (1)

USEFUL MODEL FORMULA A method of predicting the development of osteoarthritis, which includes a clinical examination, radiography, which is distinguished by the fact that the polymorphism of the nitric oxide synthase gene (6ЕМО5 17860), the content of endothelin, folic acid, transforming growth factor beta 1 (TGF- DI1), interleukin 6 (IL-6) and with homozygous carrier 786-SS, levels of endothelin "10 ng/ml, folic acid "6 ng/ml, TFR-DI "14 ng/ml, IL-b "10 ng/ml predict the development of osteoarthritis. 0000 Computer Naverstka OO. Gergil 00000000 777 Ministry of Economic Development, Trade and Agriculture of Ukraine, 00000 st. M. Hrushevskyi, 12/2, Kyiv, 01008, Ukraine SE "Ukrainian Institute of Intellectual Property", str. Glazunova, 1, Kyiv - 42, 01601