UA138766U - METHOD FOR PREDICTING THE DEVELOPMENT OF OSTEOARTHRITIS - Google Patents

Abstract

The method of predicting the development of osteoarthritis includes clinical examination, radiography. Additionally, in the patient's serum determine the polymorphism of the nitric oxide synthase gene (eNOS T786C), the content of endothelin, C-terminal propeptide of collagen type I (SISR), oxyproline, interleukin 6 (IL-6), C-reactive protein (SRP), th with homozygous carrier 786-CC, endothelin levels> 10 ng / ml, SISR <102 ng / ml, oxyproline> 15 μmol / l, IL-6> 10 ng / l, PSA> 6 mg / l, homocysteine> 20 μmol / l predict the development of osteoarthritis.

Description

The proposed useful model belongs to medicine, in particular to orthopedics and rheumatology. It is prescribed and can be used in the diagnosis of the development of osteoarthritis in the early stages.

Methods of predicting the development of osteoarthritis are known. These include x-rays, studies of biopsies of the synovial membrane, synovial fluid, and cartilage biopsies (Okorokov

A.N. Diagnosis of diseases of internal organs. - M., 2001. - T. 2. - E. 186-196). The disadvantage of these methods is the lack of the possibility of predicting the dynamics of the process in the early subclinical stages, preventing its development and possible complications due to the internal characteristics of the body.

The basis of a useful model is the task of developing a method that would allow predicting the development of osteoarthritis in the early stages.

The task is solved by the fact that in the method of predicting the development of osteoarthritis, which includes a clinical examination and radiography, the polymorphism of the nitric oxide synthase gene (2EMO5 T786C), the content of endothelin, the C-terminal propeptide of type I collagen (SICP), oxyproline, is determined in the patient's blood serum. interleukin 6 (IL-6), C-reactive protein (CRP), homocysteine and with homozygous carrier 786-SS, endothelin levels 210 ng/ml, SISR "102 ng/ml, oxyproline 215 μmol/l, IL-6"10 ng/l, SRP »b mg/l, homocysteine 220 μmol/l predict the development of osteoarthritis.

Application of the method. During hospitalization, the patient is examined, x-rays are taken, the eMmo5 1786C gene polymorphism is determined, the endothelin content is determined by the immunoenzymatic method,

SISR, oxyproline, IL-6, SRP, homocysteine. With homozygous carrier 786-SS and levels of endothelin 210 ng/ml, SISR "102 ng/ml, oxyproline 215 μmol/l, IL-b6 210 ng/l, SRP "6 mg/l, homocysteine 220 μmol/l predict the development of osteoarthritis .

An example of using the method.

Patient U., 65 years old, was hospitalized in the clinic due to pain syndrome of the left hip joint. Examined, x-ray taken. No signs of osteoarthritis were found. The eMO5 1786C gene polymorphism and the content of endothelin, SISR, oxyproline, IL-6, SRP, and homocysteine were determined in the blood serum. A homozygous carrier of 786-SS was established, the levels of endothelin - 23 ng/ml, SICP - 78 ng/ml, oxyproline - 32 μmol/l, IL-6 - 22 ng/l,

From SRP - 15 mg/l, homocysteine - 38 μmol/l. The development of osteoarthritis was diagnosed. After 12 months, X-rays revealed signs of osteoarthritis.

Thus, the proposed method is informative and allows diagnosing the development of osteoarthritis at an early stage.

Claims (1)

USEFUL MODEL FORMULA A method of predicting the development of osteoarthritis, which includes a clinical examination, radiography, which is distinguished by the fact that the polymorphism of the nitric oxide synthase gene (6ЕМО5 1786C), the content of endothelin, the C-terminal propeptide of type I collagen is additionally determined in the patient's blood serum (SICP), oxyprolin, interleukin 6 (IL-6), C-reactive protein (CRP), homocysteine and with homozygous carrier 786-SS, endothelin levels 210 ng/ml, SICP "102 ng/ml, oxyproline 215 μmol/l , IL-6 »10 ng/l, SRP »b mg/l, homocysteine 220 μmol/l predict the development of osteoarthritis.