UA138691U - METHOD FOR PREDICTING THE DEVELOPMENT OF OSTEOARTHRITIS - Google Patents

Abstract

The method of predicting the development of osteoarthritis includes clinical examination, radiography. Additionally, in the patient's serum determine the polymorphism of the genes of methylenetetrahydrofolate reductase (MTHFR C677T), nitric oxide synthase (eNOS T786C), the content of endothelin, pyridinoline, interleukin 6 (IL-6), C-reactive protein C TT, 786-CC and endothelin levels> 10 ng / ml, pyridinoline> 8 ng / ml, IL-6> 10 ng / l, PSA> 6 mg / l, homocysteine> 20 μmol / l predict the development of osteoarthritis.

Description

The proposed useful model for predicting the development of osteoarthritis belongs to medicine, in particular to orthopedics and rheumatology. It is prescribed and can be used in diagnosing the development of osteoarthritis in the early stages.

Methods of predicting the development of osteoarthritis are known. These include x-rays, examination of biopsies of the synovial membrane, synovial fluid, cartilage biopsy TSA.N.

Okorokov Diagnosis of diseases of internal organs. - M., 2001. - Vol. 2. - P. 186-196). The disadvantage of these methods is the lack of the possibility of predicting the dynamics of the process in the early subclinical stages, preventing its development and possible complications due to the internal characteristics of the body.

The basis of a useful model is the task of developing a method that would allow predicting the development of osteoarthritis in the early stages.

The set task is solved by the fact that, in addition to clinical examination and radiography, polymorphism of methylenetetrahydrofolate reductase genes (MTNEV) is determined in the patient's blood serum

С677Т), nitric oxide synthase (6ЭМО5 1786С), content of endothelin, pyridinoline, interleukin 6 (IL-b), C-reactive protein (SRP), homocysteine. With homozygous carriers of 677-HT, 786-SS, levels of endothelin » 10 ng/ml, pyridinoline » 8 ng/ml, IL-6 » 10 ng/l, PSA » 6 mg/l, homocysteine » 20 μmol/l predict development osteoarthritis

Application of the method. During hospitalization, the patient is examined, x-rays are taken, the polymorphism of MTNEV C677T, eMmo5 T786C genes is determined, the content of endothelin, pyridinoline, IL-6, SRP, homocysteine is determined by the immunoenzymatic method. With homozygous carriers of 677-T, 786-SS, levels of endothelin » 10 ng/ml, pyridinoline » 8 ng/ml, IL-6 » 10 ng/l, PSA » 6 mg/l, homocysteine » 20 μmol/l predict the development osteoarthritis

A specific example of using the method.

Patient L., 63 years old, was hospitalized in the clinic due to pain syndrome in the right hip joint. Examined, X-ray taken. No signs of osteoarthritis were found. The polymorphism of MTNEV C677T and eMmo5 17860 genes was determined in blood serum. The content of endothelin, pyridinoline, IL-6, SRP, and homocysteine was determined by immunoenzymatic method. A homozygous carrier of 677-T and 786-SS was established, the levels of endothelin - 22 ng/ml, pyridinoline - 14 ng/ml, IL - 6-25 ng/l, SRP - 15 mg/l, homocysteine - 32 μmol/l. The development of osteoarthritis was diagnosed.

After 11 months, X-rays revealed signs of osteoarthritis.

Thus, the proposed method is informative and allows diagnosing the development of osteoarthritis at an early stage.

Claims (1)

USEFUL MODEL FORMULA The method of predicting the development of osteoarthritis, which includes a clinical examination, radiography, which is distinguished by the fact that the polymorphism of methylenetetrahydrofolate reductase (MTNEV C677T), nitric oxide synthase (EMO5 1786С), the content of endothelin, pyridinoline, interleukin 6 (IL-6), C-reactive protein (CRP), homocysteine and with homozygous carrier 677-TT, 786-SS and levels of endothelin 210 ng/ml, pyridinoline »8 ng/ml, IL-b »10 ng/l, SRP »b mg/l, homocysteine 220 μmol/l predict the development of osteoarthritis.